Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMO4 Gene

protein-coding   GIFtS: 61
GCID: GC01P087794

LIM Domain Only 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Domain Only 41 2
Breast Tumor Autoantigen2 3
LMO-42 3
LIM Domain Only Protein 42 3
LIM Domain Transcription Factor LMO42

External Ids:    HGNC: 66441   Entrez Gene: 85432   Ensembl: ENSG000001430137   OMIM: 6031295   UniProtKB: P619683   

Export aliases for LMO4 gene to outside databases

Previous GC identifers: GC01P088293 GC01P086963 GC01P087086 GC01P087216 GC01P087506 GC01P087566 GC01P085907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMO4 Gene:
This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The
encoded protein may play a role as a transcriptional regulator or as an oncogene. (provided by RefSeq, Aug 2008)

GeneCards Summary for LMO4 Gene: 
LMO4 (LIM domain only 4) is a protein-coding gene. Diseases associated with LMO4 include acute t cell leukemia, and sporadic breast cancer. GO annotations related to this gene include enhancer sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968
Function: Probable transcriptional factor (By similarity)

Gene Wiki entry for LMO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMO4 gene promoter:
         Oct-B1   oct-B2   oct-B3   AP-2gamma   SRY   POU2F1a   STAT3   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for LMO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

LMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P087794:  view genomic region     (about GC identifiers)

Start:
87,794,151 bp from pter      End:
87,814,606 bp from pter
Size:
20,456 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968 (See protein sequence)
Recommended Name: LIM domain transcription factor LMO4  
Size: 165 amino acids; 17994 Da
Subunit: Interacts strongly with LDBS. Interacts with DEAF1, CLIM1 and CLIM2. Interacts (via the LIM zinc-binding
domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1
transcriptional activity (By similarity)
1 PDB 3D structure from and Proteopedia for LMO4:
2L4Z (3D)    
Secondary accessions: D3DT23 O00158 O88894

Explore the universe of human proteins at neXtProt for LMO4: NX_P61968

Explore proteomics data for LMO4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61968

  • LMO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMO4 Protein Expression
    REFSEQ proteins: NP_006760.1  
    ENSEMBL proteins: 
     ENSP00000359575   ENSP00000359573  

    Human Recombinant Protein Products for LMO4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LMO4
    OriGene Protein Over-expression Lysate for LMO4
    OriGene MassSpec for LMO4 
    OriGene Custom Protein Services for LMO4
    GenScript Custom Purified and Recombinant Proteins Services for LMO4
    Novus Biologicals LMO4 Protein
    Novus Biologicals LMO4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LMO4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex ISS--

    LMO4 for ontologies           About GeneDecksing



    LMO4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMO4
    R&D Systems Antibodies for LMO4
    OriGene Antibodies for LMO4
    OriGene Custom Antibody Services for LMO4
    GenScript Custom Superior Antibodies Services for LMO4
    Novus Biologicals LMO4 Antibodies
    Abcam antibodies for LMO4
    Cloud-Clone Corp. Antibodies for LMO4 
    ThermoFisher Antibodies for LMO4
    LSBio Antibodies in human, mouse, rat for LMO4 

    Assay Products for LMO4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMO4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMO4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMO4 
    Cloud-Clone Corp. CLIAs for LMO4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P61968

    ProtoNet protein and cluster: P61968

    UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968
    Similarity: Contains 2 LIM zinc-binding domains


    LMO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMO4_HUMAN, P61968
    Function: Probable transcriptional factor (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001158enhancer sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10209267
    GO:0005515protein binding ----
    GO:0008134transcription factor binding ISS--
    GO:0008270zinc ion binding IEA--
         
    LMO4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMO4:
     Increased cell transformation 

         12 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Lmo4):
     behavior/neurological  craniofacial  embryogenesis  growth/size  hearing/vestibular/ear 
     hematopoietic system  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton  vision/eye 

    LMO4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LMO4: Lmo4tm2Sho Lmo4tm1Thr Lmo4tm1.1Gng

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMO4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMO4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMO4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMO4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO4
    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO4 (see all 89):
    hsa-miR-300 hsa-miR-3653 hsa-miR-374a hsa-miR-3921 hsa-miR-200b hsa-miR-642b hsa-miR-192* hsa-miR-490-5p
    SwitchGear 3'UTR luciferase reporter plasmidLMO4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LMO4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMO4
    Sirion Biotech Customized adenovirus for overexpression of LMO4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LMO4 (see all 9)
    OriGene ORF clones in mouse, rat for LMO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMO4 (NM_006769)
    Sino Biological Human cDNA Clone for LMO4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO4
    Sirion Biotech Customized lentivirus for stable overexpression of LMO4 
                         Customized lentivirus expression plasmids for stable overexpression of LMO4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMO4
    Search LifeMap BioReagents cell lines for LMO4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LMO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1IL6-mediated signaling events
    IL6-mediated signaling events


    1 BioSystems Pathway for LMO4
        IL6-mediated signaling events



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LMO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for LMO4 (P619682, 3 ENSP000003595734) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253396 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253396 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253396 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253396 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253396 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001843neural tube closure ISS--
    GO:0003281ventricular septum development IEA--
    GO:0006366transcription from RNA polymerase II promoter ISS--
    GO:0021514ventral spinal cord interneuron differentiation IEA--
    GO:0021522spinal cord motor neuron differentiation IEA--

    LMO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMO4

    Search CenterWatch for drugs/clinical trials and news about LMO4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LMO4 gene: 
    NM_006769.3  

    Unigene Cluster for LMO4:

    LIM domain only 4
    Hs.436792  [show with all ESTs]
    Unigene Representative Sequence: NM_006769
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370544(uc001dmi.3 uc001dmj.3) ENST00000495705 ENST00000370542
    ENST00000489303
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO4
    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO4 (see all 89):
    hsa-miR-300 hsa-miR-3653 hsa-miR-374a hsa-miR-3921 hsa-miR-200b hsa-miR-642b hsa-miR-192* hsa-miR-490-5p
    SwitchGear 3'UTR luciferase reporter plasmidLMO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LMO4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO4
    Clone
    Products:
         
    OriGene clones in human, mouse for LMO4 (see all 9)
    OriGene ORF clones in mouse, rat for LMO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMO4 (NM_006769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO4
    Sirion Biotech Customized lentivirus for stable overexpression of LMO4 
                         Customized lentivirus expression plasmids for stable overexpression of LMO4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMO4
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMO4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO4

    Additional mRNA sequence: 

    AK292578.1 AY321514.1 BC003600.1 BC017673.1 BC065818.1 U24576.1 

    14 DOTS entries:

    DT.86854013  DT.100836502  DT.121330950  DT.100836754  DT.100836758  DT.95315842  DT.97813584  DT.100836749 
    DT.100836752  DT.100836761  DT.121330917  DT.92438473  DT.95099779  DT.95235539 

    24/340 AceView cDNA sequences (see all 340):

    F03769 AW161069 AI002102 BM697993 BC065818 AI798369 AA670311 CD365930 
    AW160465 AA235030 AI129757 AI699430 F10701 BP339569 AW160472 CD723252 
    BU619915 AI827349 CD722882 AI952998 Z40825 AI698254 CR599134 AW161961 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LMO4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -     -     -     -                                             
    SP2:                                -                                             
    SP3:              -           -     -                                             
    SP4:                          -     -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for LMO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMO4 expression in normal human tissues (normalized intensities)      LMO4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LMO4 Expression
    About this image


    LMO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             postcentral gyrus   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived hematopoietic stem cells

    See LMO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMO4

    SOURCE GeneReport for Unigene cluster: Hs.436792
        SABiosciences Custom PCR Arrays for LMO4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMO4
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMO4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMO4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmo41 , 5 LIM domain only 41, 5 95.76(n)1
    100(a)1
      3 (68.61 cM)5
    169111  NM_001161769.11  NP_001155241.11 
     1441885305 
    chicken
    (Gallus gallus)
    Aves LMO41 LIM domain only 4 92.53(n)
    98.79(a)
      373901  NM_204112.1  NP_989443.1 
    lizard
    (Anolis carolinensis)
    Reptilia LMO46
    LIM domain only 4
    99(a)
    1 ↔ 1
    4(96976099-96992830)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245882 Xenopus laevis transcribed sequence with strong similarity more 84.92(n)    CD301053.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.192362 Danio rerio LIM-only 4 (LMO4) mRNA, complete cds 84.78(n)    AF398515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57081 , 3 CG57081 50(a)3
    55.47(n)1
    54.2(a)1
      31B13
    343611  NM_135515.11  NP_609359.11 


    ENSEMBL Gene Tree for LMO4 (if available)
    TreeFam Gene Tree for LMO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMO4 gene
    ISL12  LMO22  LHX22  LHX92  LMX1B2  LHX52  LMO12  LHX62  
    LHX12  LMX1A2  LMO32  LHX32  LHX42  LHX82  ISL22  
    17 SIMAP similar genes for LMO4 using alignment to 1 protein entry:     LMO4_HUMAN:
    LMO3    LMO1    LHX4    ISL1    LHX2    LMO2
    LHX9    LHX1    LHX3    LHX8    LMX1A    LHX6
    ISL2    LIMK1    LMX1B    ABLIM1    PXN

    LMO4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/478 SNPs in LMO4 are shown (see all 478)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510516771,2
    C--87792236(+) TTTTAA/GTGCAT 1 -- us2k10--------
    rs1409571631,2
    --87792385(+) TAAGGC/TCCAGA 1 -- us2k10--------
    rs727259001,2
    C--87792681(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1904606351,2
    --87792682(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs38061791,2
    C--87792729(-) AAGTTG/TCACTG 1 -- us2k13Minor allele frequency- T:0.21NA EA 242
    rs1822820231,2
    C--87792945(+) TGTCTA/CGCCAG 1 -- us2k10--------
    rs38061781,2
    C,F--87793001(-) TCATAC/TTGTGT 1 -- us2k10--------
    rs1382206951,2
    --87793013(+) AACTTA/GCCCCA 1 -- us2k10--------
    rs1852895351,2
    --87793044(+) GATACG/TTAGCA 1 -- us2k10--------
    rs1157752291,2
    C,F--87793081(+) TTCCAC/TCAGAA 1 -- us2k11Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for LMO4 (87794151 - 87814606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv24748CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LMO4
    DNA2.0 Custom Variant and Variant Library Synthesis for LMO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603129    OMIM disorders: --

    18 diseases for LMO4:    About MalaCards
    acute t cell leukemia    sporadic breast cancer    pancreatic ductal adenocarcinoma    prostate cancer, progression of
    rhabdomyosarcoma    t-cell leukemia    breast cancer    neuroblastoma
    prostate cancer    cerebritis    rheumatoid arthritis    prostatitis
    adenocarcinoma    arthritis    pancreatitis    leukemia
    squamous cell carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for LMO4:
    Acute T cell leukemia

    LMO4 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for LMO4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 59.3 1 11734645 (1)
    t-all 50.2 1 15930276 (1)
    breast carcinoma 38.8 2 11734645 (1), 12925972 (1)
    breast cancer 31.5 28 12925972 (4), 15897450 (3), 17452977 (2), 11734645 (1) (see all 8)
    tumors 7.68 16 12925972 (2), 11734645 (1), 16288053 (1), 11888886 (1) (see all 7)
    cancer 0 1 10556429 (1)

    Genetic Association Database (GAD): LMO4
    Human Genome Epidemiology (HuGE) Navigator: LMO4 (13 documents)

    Export disorders for LMO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMO4 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with LMO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Case-control study of six genes asymmetrically expres sed in the two cerebral hemispheres: association of BAIAP2 with attention-defic it/hyperactivity disorder. (PubMed id 19733838)1, 4, 9 RibasAcs M....Cormand B. (2009)
    2. Molecular cloning of LMO4, a new human LIM domain gene. (PubMed id 10209267)1, 2, 9 Racevskis J.... Ruan H. (1999)
    3. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    4. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis. (PubMed id 18615156)1, 4 Liu C....Gregersen P.K. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. (PubMed id 12925972)1, 9 Sutherland K.D....Campbell I.G. (2003)
    7. LIM only 4 is overexpressed in late stage pancreas cancer. (PubMed id 19099607)1, 9 Yu J....Tanaka M. (2008)
    8. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. (PubMed id 16288053)1, 9 Singh R.R....Kumar R. (2005)
    9. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. (PubMed id 12878195)1, 9 Manetopoulos C....Axelson H. (2003)
    10. Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. (PubMed id 15897450)1, 9 Sum E.Y....Visvader J.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8543 HGNC: 6644 AceView: LMO4 Ensembl:ENSG00000143013 euGenes: HUgn8543
    ECgene: LMO4 H-InvDB: LMO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMO4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LMO4 gene:
    Search GeneIP for patents involving LMO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LMO4
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for LMO4 (LMO4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LMO4   OriGene RNAi products in human, mouse, rat for LMO4  
     OriGene qPCR primer pairs and template standards for LMO4   OriGene Protein Over-expression Lysate for LMO4  
     OriGene MassSpec something-or-other for LMO4   OriGene clones in human, mouse for LMO4  
     OriGene qSTAR qPCR primer pairs in human, mouse for LMO4   OriGene Purified Protein for LMO4  
     OriGene ORF clones in mouse, rat for LMO4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LMO4   OriGene Custom Protein Services for LMO4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LMO4
     QIAGEN SeqTarget long-range PCR primers for resequencing LMO4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMO4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO4
     GenScript Custom Purified and Recombinant Proteins Services for LMO4 GenScript cDNA clones with any tag delivered in your preferred vector for LMO4
     GenScript Custom Assay Services for LMO4 GenScript Custom Superior Antibodies Services for LMO4
     GenScript Custom overexpressing Cell Line Services for LMO4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LMO4 promoter
     Search Chromatin IP Primers for LMO4
     RT2 qPCR Primer Assay in human, mouse, rat LMO4
     GNC Network for LMO4
     SABiosciences Custom PCR Arrays for LMO4
     Search Tocris compounds for LMO4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for LMO4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LMO4 antibodies
     LMO4 proteins
     LMO4 lysates
     Antibodies for LMO4
     See all of Abcam's Antibodies, Kits and Proteins for LMO4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LMO4
     Antibodies for LMO4
     ELISAs for LMO4
     CLIAs for LMO4
     Search LifeMap BioReagents cell lines for LMO4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO4
     SwitchGear 3'UTR luciferase reporter plasmids for LMO4
     SwitchGear Promoter luciferase reporter plasmids for LMO4
     ThermoFisher Antibodies for LMO4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LMO4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMO4
    Customized:
     lentivirus for stable overexpression of LMO4
     lentivirus expression plasmids for stable overexpression of LMO4
     adenovirus for overexpression of LMO4
     LSBio Antibodies in human, mouse, rat for LMO4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LMO4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4