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LMO4 Gene

protein-coding   GIFtS: 59
GCID: GC01P087794

LIM Domain Only 4

  See LMO4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Domain Only 41 2
Breast Tumor Autoantigen2 3
LMO-42 3
LIM Domain Only Protein 42 3
LIM Domain Transcription Factor LMO42

External Ids:    HGNC: 66441   Entrez Gene: 85432   Ensembl: ENSG000001430137   OMIM: 6031295   UniProtKB: P619683   

Export aliases for LMO4 gene to outside databases

Previous GC identifers: GC01P088293 GC01P086963 GC01P087086 GC01P087216 GC01P087506 GC01P087566 GC01P085907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMO4 Gene:
This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The
encoded protein may play a role as a transcriptional regulator or as an oncogene. (provided by RefSeq, Aug 2008)

GeneCards Summary for LMO4 Gene:
LMO4 (LIM domain only 4) is a protein-coding gene. Diseases associated with LMO4 include acute t cell leukemia. GO annotations related to this gene include enhancer sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is LMO2.

UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968
Function: Probable transcriptional factor (By similarity)

Gene Wiki entry for LMO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMO4 gene promoter:
         Oct-B1   oct-B2   oct-B3   AP-2gamma   SRY   POU2F1a   STAT3   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMO4 promoter sequence
   Search Chromatin IP Primers for LMO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

LMO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P087794:  view genomic region     (about GC identifiers)

Start:
87,794,151 bp from pter      End:
87,814,606 bp from pter
Size:
20,456 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968 (See protein sequence)
Recommended Name: LIM domain transcription factor LMO4  
Size: 165 amino acids; 17994 Da
Subunit: Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1
and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains);
the interaction represses BRCA1 transcriptional activity (By similarity)
1 PDB 3D structure from and Proteopedia for LMO4:
2L4Z (3D)    
Secondary accessions: D3DT23 O00158 O88894

Explore the universe of human proteins at neXtProt for LMO4: NX_P61968

Explore proteomics data for LMO4 at MOPED


See LMO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006760.1  
ENSEMBL proteins: 
 ENSP00000359575   ENSP00000359573  

LMO4 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for LMO4

 
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LMO4 Assay Products:

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Cloud-Clone Corp. ELISAs for LMO4
Cloud-Clone Corp. CLIAs for LMO4
Search eBioscience for ELISAs for LMO4 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry P61968

ProtoNet protein and cluster: P61968

UniProtKB/Swiss-Prot: LMO4_HUMAN, P61968
Similarity: Contains 2 LIM zinc-binding domains


Find genes that share domains with LMO4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: LMO4_HUMAN, P61968
Function: Probable transcriptional factor (By similarity)

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001158enhancer sequence-specific DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity TAS10209267
GO:0005515protein binding ----
GO:0008134transcription factor binding ISS--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with LMO4           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for LMO4:
 Increased cell transformation 

     12 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Lmo4):
 behavior/neurological  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
 hematopoietic system  integument  limbs/digits/tail  mortality/aging  nervous system 
 skeleton  vision/eye 

Find genes that share phenotypes with LMO4           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for LMO4: Lmo4tm2Sho Lmo4tm1Thr Lmo4tm1.1Gng

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMO4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMO4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMO4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMO4

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat LMO4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LMO4 (see all 89):
hsa-miR-300 hsa-miR-3653 hsa-miR-374a hsa-miR-3921 hsa-miR-200b hsa-miR-642b hsa-miR-192* hsa-miR-490-5p
SwitchGear 3'UTR luciferase reporter plasmidLMO4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LMO4
Predesigned siRNA for gene silencing in human, mouse, rat LMO4

Gene Editing
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OriGene ORF clones in mouse, rat for LMO4
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GenScript: all cDNA clones in your preferred vector: LMO4 (NM_006769)
Sino Biological Human cDNA Clone for LMO4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO4

Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005667transcription factor complex ISS--

Find genes that share ontologies with LMO4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for LMO4 About    
See pathways by source

SuperPathContained pathways About
1IL6-mediated signaling events
IL6-mediated signaling events


1 BioSystems Pathway for LMO4
    IL6-mediated signaling events



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LMO4
Interactions:

    GeneGlobe Interaction Network for LMO4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for LMO4 (P619682, 3 ENSP000003595734) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
InteractantInteraction Details
GeneCardExternal ID(s)
CSNK2BP678702, 3MINT-8253396 I2D: score=2 
ENSG00000206406P678702, 3MINT-8253396 I2D: score=2 
ENSG00000224398P678702, 3MINT-8253396 I2D: score=2 
ENSG00000224774P678702, 3MINT-8253396 I2D: score=2 
ENSG00000228875P678702, 3MINT-8253396 I2D: score=2 
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Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001843neural tube closure ISS--
GO:0003281ventricular septum development IEA--
GO:0006366transcription from RNA polymerase II promoter ISS--
GO:0021514ventral spinal cord interneuron differentiation IEA--
GO:0021522spinal cord motor neuron differentiation IEA--

Find genes that share ontologies with LMO4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LMO4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for LMO4 gene: 
NM_006769.3  

Unigene Cluster for LMO4:

LIM domain only 4
Hs.436792  [show with all ESTs]
Unigene Representative Sequence: NM_006769
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000370544(uc001dmi.3 uc001dmj.3) ENST00000495705 ENST00000370542
ENST00000489303
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LMO4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LMO4 (see all 89):
hsa-miR-300 hsa-miR-3653 hsa-miR-374a hsa-miR-3921 hsa-miR-200b hsa-miR-642b hsa-miR-192* hsa-miR-490-5p
SwitchGear 3'UTR luciferase reporter plasmidLMO4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LMO4
Predesigned siRNA for gene silencing in human, mouse, rat LMO4
Clone
Products:
     
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OriGene ORF clones in mouse, rat for LMO4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: LMO4 (NM_006769)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LMO4
OriGene qSTAR qPCR primer pairs in human, mouse for LMO4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO4
  QuantiTect SYBR Green Assays in human, mouse, rat LMO4
  QuantiFast Probe-based Assays in human, mouse, rat LMO4

Additional mRNA sequence: 

AK292578.1 AY321514.1 BC003600.1 BC017673.1 BC065818.1 U24576.1 

14 DOTS entries:

DT.86854013  DT.100836502  DT.121330950  DT.100836754  DT.100836758  DT.95315842  DT.97813584  DT.100836749 
DT.100836752  DT.100836761  DT.121330917  DT.92438473  DT.95099779  DT.95235539 

Selected AceView cDNA sequences (see all 340):

AA156410 CD722882 AA649073 F10701 CB268557 AA889827 BE676628 AA235030 
AW160472 BU557026 AA639627 AA926894 AW157236 R48353 Z40825 AW161961 
AI243226 CK430993 BF724799 F04858 AI269782 AW160473 BQ061161 CD723252 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LMO4    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1:              -     -     -     -                                             
SP2:                                -                                             
SP3:              -           -     -                                             
SP4:                          -     -                                             
SP5:                                                                              


ECgene alternative splicing isoforms for LMO4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LMO4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
LMO4 Expression
About this image


LMO4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Brain (Nervous System)    fully expand to see all 10 entries
         Thalamus
 
 Esophagus (Gastrointestinal Tract)
 
 Gall Bladder (Hepatobiliary System)
 
 Placenta (Extraembryonic Tissues)
 
 Stomach (Gastrointestinal Tract)
LMO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LMO4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.436792
    Custom PCR Arrays for LMO4
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for LMO4
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QuantiFast Probe-based Assays in human, mouse, rat LMO4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LMO4 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lmo41 , 5 LIM domain only 41, 5 95.76(n)1
100(a)1
  3 (68.61 cM)5
169111  NM_001161769.11  NP_001155241.11 
 1441885305 
chicken
(Gallus gallus)
Aves LMO41 LIM domain only 4 92.53(n)
98.79(a)
  373901  NM_204112.1  NP_989443.1 
lizard
(Anolis carolinensis)
Reptilia LMO46
LIM domain only 4
99(a)
1 ↔ 1
4(96976099-96992830)
African clawed frog
(Xenopus laevis)
Amphibia Xl.245882 Xenopus laevis transcribed sequence with strong similarity more 84.92(n)    CD301053.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.192362 Danio rerio LIM-only 4 (LMO4) mRNA, complete cds 84.78(n)    AF398515.1 
fruit fly
(Drosophila melanogaster)
Insecta CG57081 , 3 CG57081 50(a)3
56.94(n)1
55.83(a)1
  31B13
343611  NM_135515.11  NP_609359.11 


ENSEMBL Gene Tree for LMO4 (if available)
TreeFam Gene Tree for LMO4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LMO4 gene
LMO22  LMO32  LMO12  
17 SIMAP similar genes for LMO4 using alignment to 1 protein entry:     LMO4_HUMAN:
LMO3    LMO1    LHX4    ISL1    LHX2    LMO2
LHX9    LHX1    LHX3    LHX8    LMX1A    LHX6
LIMK1    ISL2    LMX1B    ABLIM1    PXN

Find genes that share paralogs with LMO4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LMO4 (see all 478)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1510516771,2
C--87792236(+) TTTTAA/GTGCAT 1 -- us2k10--------
rs1409571631,2
--87792385(+) TAAGGC/TCCAGA 1 -- us2k10--------
rs727259001,2
C--87792681(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1904606351,2
--87792682(+) TTTTTA/TAAAAA 1 -- us2k10--------
rs38061791,2
C--87792729(-) AAGTTG/TCACTG 1 -- us2k13Minor allele frequency- T:0.21NA EA 242
rs1822820231,2
C--87792945(+) TGTCTA/CGCCAG 1 -- us2k10--------
rs38061781,2
C,F--87793001(-) TCATAC/TTGTGT 1 -- us2k10--------
rs1382206951,2
--87793013(+) AACTTA/GCCCCA 1 -- us2k10--------
rs1852895351,2
--87793044(+) GATACG/TTAGCA 1 -- us2k10--------
rs1157752291,2
C,F--87793081(+) TTCCAC/TCAGAA 1 -- us2k11Minor allele frequency- T:0.02NA 120

HapMap Linkage Disequilibrium report for LMO4 (87794151 - 87814606 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for LMO4:    About this table    
Variant IDTypeSubtypePubMed ID
esv24748CNV Gain19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LMO4
DNA2.0 Custom Variant and Variant Library Synthesis for LMO4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 603129    OMIM disorders: --

1 disease for LMO4:    
About MalaCards
acute t cell leukemia

1 disease from the University of Copenhagen DISEASES database for LMO4:
Acute T cell leukemia

Find genes that share disorders with LMO4           About GenesLikeMe

6 Novoseek inferred disease relationships for LMO4 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell 59.3 1 11734645 (1)
t-all 50.2 1 15930276 (1)
breast carcinoma 38.8 2 11734645 (1), 12925972 (1)
breast cancer 31.5 28 12925972 (4), 15897450 (3), 17452977 (2), 11734645 (1) (see all 8)
tumors 7.68 16 12925972 (2), 11734645 (1), 16288053 (1), 11888886 (1) (see all 7)
cancer 0 1 10556429 (1)

Genetic Association Database (GAD): LMO4
Human Genome Epidemiology (HuGE) Navigator: LMO4 (13 documents)

Export disorders for LMO4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LMO4 gene, integrated from 10 sources (see all 59):
(articles sorted by number of sources associating them with LMO4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PubMed id 19733838)1, 4, 9 RibasAcs M....Cormand B. (Biol. Psychiatry 2009)
  2. Molecular cloning of LMO4, a new human LIM domain gene. (PubMed id 10209267)1, 2, 9 Racevskis J.... Ruan H. (Biochim. Biophys. Acta 1999)
  3. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
  4. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. (PubMed id 18615156)1, 4 Liu C....Gregersen P.K. (Mol. Med. 2008)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. (PubMed id 12925972)1, 9 Sutherland K.D....Campbell I.G. (Int. J. Cancer 2003)
  7. LIM only 4 is overexpressed in late stage pancreas cancer. (PubMed id 19099607)1, 9 Yu J....Tanaka M. (Mol. Cancer 2008)
  8. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. (PubMed id 16288053)1, 9 Singh R.R....Kumar R. (Cancer Res. 2005)
  9. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. (PubMed id 12878195)1, 9 Manetopoulos C....Axelson H. (Biochem. Biophys. Res. Commun. 2003)
  10. Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. (PubMed id 15897450)1, 9 Sum E.Y....Visvader J.E. (Proc. Natl. Acad. Sci. U.S.A. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8543 HGNC: 6644 AceView: LMO4 Ensembl:ENSG00000143013 euGenes: HUgn8543
ECgene: LMO4 H-InvDB: LMO4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for LMO4 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LMO4 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LMO4 gene:
Search GeneIP for patents involving LMO4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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