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Aliases for LMO4 Gene

Aliases for LMO4 Gene

  • LIM Domain Only 4 2 3 5
  • LIM Domain Only Protein 4 3 4
  • Breast Tumor Autoantigen 3 4
  • LMO-4 3 4
  • LIM Domain Transcription Factor LMO4 3
  • LIM-Only 4 Protein 3

External Ids for LMO4 Gene

Previous GeneCards Identifiers for LMO4 Gene

  • GC01P088293
  • GC01P086963
  • GC01P087086
  • GC01P087216
  • GC01P087506
  • GC01P087566
  • GC01P087794
  • GC01P085907

Summaries for LMO4 Gene

Entrez Gene Summary for LMO4 Gene

  • This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]

GeneCards Summary for LMO4 Gene

LMO4 (LIM Domain Only 4) is a Protein Coding gene. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Neuroscience. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enhancer sequence-specific DNA binding. An important paralog of this gene is LMO1.

UniProtKB/Swiss-Prot for LMO4 Gene

  • Probable transcriptional factor.

Gene Wiki entry for LMO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO4 Gene

Genomics for LMO4 Gene

Regulatory Elements for LMO4 Gene

Enhancers for LMO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F087131 0.9 ENCODE 4.4 -196.4 -196395 1.6 ELF3 INSM2 KLF17 ARID4B ZNF48 ZNF2 RAD21 CBX5 ZNF143 ZNF391 LINC01140 LMO4 GC01M087128 GC01M087175
GH01F087203 1.1 FANTOM5 Ensembl 1.9 -125.5 -125468 1.2 ZNF146 TBL1XR1 BMI1 RELA EGR1 CREM MAZ MTA2 CBFB TRIM22 HS2ST1 LMO4 GC01M087204 GC01M087194
GH01F087223 1.3 FANTOM5 Ensembl ENCODE 1.5 -103.0 -102971 3.7 ELF3 JUN TEAD4 CEBPG TEAD3 POLR2A FOS GATAD2A ZNF263 NFIA LINC01140 HS2ST1 LMO4 GC01P087235 LOC101927844
GH01F087327 1.6 VISTA ENCODE 0.8 +1.5 1544 5.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ZNF263 LMO4 GC01P087340
GH01F087334 2.3 FANTOM5 ENCODE 0.4 +6.8 6829 3.8 ELF3 TBP PKNOX1 CREB3L1 RAD21 SCRT2 ETV6 EGR2 ZBTB11 ELF1 LMO4 GC01P087340
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMO4 Gene

87,328,468 bp from pter
87,348,923 bp from pter
20,456 bases
Plus strand

Genomic View for LMO4 Gene

Genes around LMO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO4 Gene

Proteins for LMO4 Gene

  • Protein details for LMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LIM domain transcription factor LMO4
    Protein Accession:
    Secondary Accessions:
    • D3DT23
    • O00158
    • O88894

    Protein attributes for LMO4 Gene

    165 amino acids
    Molecular mass:
    17994 Da
    Quaternary structure:
    • Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity (By similarity).

    Three dimensional structures from OCA and Proteopedia for LMO4 Gene

neXtProt entry for LMO4 Gene

Post-translational modifications for LMO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LMO4 (LMO4)
  • Abcam antibodies for LMO4
  • Santa Cruz Biotechnology (SCBT) Antibodies for LMO4

No data available for DME Specific Peptides for LMO4 Gene

Domains & Families for LMO4 Gene

Gene Families for LMO4 Gene

Protein Domains for LMO4 Gene


Suggested Antigen Peptide Sequences for LMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LIM zinc-binding domains.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LMO4: view

Function for LMO4 Gene

Molecular function for LMO4 Gene

UniProtKB/Swiss-Prot Function:
Probable transcriptional factor.

Gene Ontology (GO) - Molecular Function for LMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 10209267
GO:0005515 protein binding IPI 15231748
GO:0008134 transcription factor binding ISS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LMO4: view
genes like me logo Genes that share phenotypes with LMO4: view

Animal Models for LMO4 Gene

MGI Knock Outs for LMO4:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LMO4 Gene

Localization for LMO4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMO4 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex ISS --
GO:0031252 cell leading edge ISS --
genes like me logo Genes that share ontologies with LMO4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LMO4 Gene

Pathways & Interactions for LMO4 Gene

genes like me logo Genes that share pathways with LMO4: view

Pathways by source for LMO4 Gene

1 Cell Signaling Technology pathway for LMO4 Gene
1 BioSystems pathway for LMO4 Gene

Gene Ontology (GO) - Biological Process for LMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure ISS --
GO:0003281 ventricular septum development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with LMO4: view

No data available for SIGNOR curated interactions for LMO4 Gene

Transcripts for LMO4 Gene

Unigene Clusters for LMO4 Gene

LIM domain only 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMO4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: -
SP3: - - -
SP4: - -

Relevant External Links for LMO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LMO4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for LMO4 Gene

This gene is overexpressed in Testis (23.0), Ovary (18.4), NK cells (14.8), and Fetal heart (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMO4 Gene

Protein tissue co-expression partners for LMO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMO4 Gene:


SOURCE GeneReport for Unigene cluster for LMO4 Gene:

genes like me logo Genes that share expression patterns with LMO4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LMO4 Gene

Orthologs for LMO4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LMO4 34 35
  • 99.8 (n)
(Monodelphis domestica)
Mammalia LMO4 35
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia LMO4 35
  • 99 (a)
(Canis familiaris)
Mammalia LMO4 34 35
  • 97.58 (n)
(Bos Taurus)
Mammalia LMO4 34 35
  • 97.17 (n)
(Rattus norvegicus)
Mammalia Lmo4 34
  • 96.16 (n)
(Mus musculus)
Mammalia Lmo4 34 16 35
  • 95.76 (n)
(Gallus gallus)
Aves LMO4 34 35
  • 92.53 (n)
(Anolis carolinensis)
Reptilia LMO4 35
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lmo4.1 34
  • 86.67 (n)
Str.145 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24588 34
(Danio rerio)
Actinopterygii lmo4b 34 35
  • 81.41 (n)
Dr.19236 34
fruit fly
(Drosophila melanogaster)
Insecta CG5708 36 34 35
  • 56.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
Species where no ortholog for LMO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMO4 Gene

Gene Tree for LMO4 (if available)
Gene Tree for LMO4 (if available)

Paralogs for LMO4 Gene

Paralogs for LMO4 Gene

(17) SIMAP similar genes for LMO4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LMO4: view

Variants for LMO4 Gene

Sequence variations from dbSNP and Humsavar for LMO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157094 -- 87,345,394(+) aaaaa(A/G)aaaga utr-variant-3-prime
rs10157404 -- 87,329,332(+) GGCTT(C/G)CTTCC intron-variant, utr-variant-5-prime
rs1065416 -- 87,333,554(+) TATGT(G/T)TACCC intron-variant
rs10873830 -- 87,337,517(+) TACTT(C/T)AGGGT intron-variant
rs10873831 -- 87,346,719(+) GTTGA(A/G)GTGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LMO4 Gene

Variant ID Type Subtype PubMed ID
nsv1077471 CNV deletion 25765185
esv24748 CNV gain 19812545

Variation tolerance for LMO4 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO4 Gene

Disorders for LMO4 Gene

Relevant External Links for LMO4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LMO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMO4 Gene

Publications for LMO4 Gene

  1. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PMID: 19733838) RibasAcs M. … Cormand B. (Biol. Psychiatry 2009) 3 22 46 64
  2. Molecular cloning of LMO4, a new human LIM domain gene. (PMID: 10209267) Racevskis J. … Ruan H. (Biochim. Biophys. Acta 1999) 3 4 22 64
  3. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A. … Carracedo A. (Gynecol. Oncol. 2009) 3 46 64
  4. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. (PMID: 18615156) Liu C. … Gregersen P.K. (Mol. Med. 2008) 3 46 64
  5. LIM only 4 is overexpressed in late stage pancreas cancer. (PMID: 19099607) Yu J. … Tanaka M. (Mol. Cancer 2008) 3 22 64

Products for LMO4 Gene

Sources for LMO4 Gene

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