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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LMO3 Gene

protein-coding GIFtS: 54
GCID: GC12M016701

LIM domain only 3 (rhombotin-like 2)

(Previous symbol: RBTNL2)

Explore 5 diseases affiliated with
LMO3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
LIM Domain Only 3 (Rhombotin-Like 2)¹ ²		DAT1¹
RBTNL2¹ ² ³ ⁵		LIM Domain Only Protein 3²
RHOM3² ³ ⁵		Rhombotin-3³
Rhom-3¹ ²		LMO-3³
Neuronal-Specific Transcription Factor DAT1² ³		Rhombotin-3³
RBTN3² ³

External Ids:	HGNC: 6643¹	Entrez Gene: 55885²	Ensembl: ENSG00000048540⁷	OMIM: 180386⁵	UniProtKB: Q8TAP4³

ORGUL members:
	NONCODE:n411728

Export aliases for LMO3 gene to outside databases

Previous GC identifers: GC12U990051 GC12M016593 GC12M016594 GC12M016469

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMO3:

The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is

predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be

involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been

found for this gene. (provided by RefSeq, Aug 2011)

Gene Wiki entry for LMO3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LMO3 gene promoter:
GR IRF-7A aMEF-2 Nkx2-5 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LMO3 promoter sequence

Search SABiosciences Chromatin IP Primers for LMO3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMO3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3 Ensembl cytogenetic band: 12p12.3 HGNC cytogenetic band: 12p13

LMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M016701: view genomic region (about GC identifiers)

Start:	16,701,307 bp from pter	End:	16,763,528 bp from pter
Size:	62,222 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4 (See protein sequence)

Recommended Name: LIM domain only protein 3

Size: 145 amino acids; 16594 Da

Secondary accessions: B4DH35 Q58A66 Q58A67 Q8N974 Q9UDD5

Alternative splicing: 3 isoforms: Q8TAP4-1 Q8TAP4-2 Q8TAP4-3

Explore the universe of human proteins at neXtProt for LMO3: NX_Q8TAP4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TAP4

LMO3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001001395.1 NP_001230538.1 NP_001230539.1 NP_001230540.1 NP_001230541.1 NP_001230542.1 NP_061110.2

ENSEMBL proteins:

ENSP00000412479 ENSP00000413703 ENSP00000312856 ENSP00000379508 ENSP00000404386

ENSP00000445751 ENSP00000440948 ENSP00000446115 ENSP00000440099 ENSP00000437890

ENSP00000439275 ENSP00000404656 ENSP00000442786 ENSP00000444393 ENSP00000440885

ENSP00000439900 ENSP00000443807 ENSP00000442713 ENSP00000445193 ENSP00000438187

ENSP00000441360 ENSP00000445504 ENSP00000444269 ENSP00000439989 ENSP00000446095

ENSP00000446463 ENSP00000261169 ENSP00000346689

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
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	Novus Biologicals LMO3 Protein Novus Biologicals LMO3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LMO3

LMO3 Antibody Products:

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	Novus Biologicals LMO3 Antibodies
	Search for Antibodies for LMO3 at Abcam
	Uscn Antibodies for LMO3
	Search ThermoFisher Antibodies for LMO3

Assay Products for LMO3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LMO3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LMO3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LMO3 for domains About GeneDecksing

1 InterPro domain/family:

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q8TAP4

ProtoNet protein and cluster: Q8TAP4

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4

Similarity: Contains 2 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for LMO3:

Lim domain only 3

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LMO3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO3
		8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO3 (see all 104):
		hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LMO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMO3 (see all 4) OriGene shRNA RFP: LMO3 OriGene siRNA: LMO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LMO3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LMO3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LMO3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LMO3 (NM_001001395)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LMO3
		Search LifeMap BioReagents cell lines for LMO3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

LMO3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LMO3:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Lmo3^tm1Thr for LMO3
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lmo3):

mortality/aging

normal

LMO3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LMO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/34 Interacting proteins for LMO3 (Q8TAP4³ ENSP00000346689⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LDB1	Q86U70³, ENSP00000392466⁴	I2D: score=5 STRING: ENSP00000392466
CCDC85B	Q15834³, ENSP00000311695⁴	I2D: score=4 STRING: ENSP00000311695
GABPB1	Q06547³, ENSP00000370259⁴	I2D: score=4 STRING: ENSP00000370259
MBIP	Q9NS73³, ENSP00000324444⁴	I2D: score=4 STRING: ENSP00000324444
ZBTB43	O43298³, ENSP00000362556⁴	I2D: score=4 STRING: ENSP00000362556

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

LMO3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LMO3
Search CenterWatch for drugs/clinical trials and news about LMO3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LMO3 gene (7 alternative transcripts):

NM_001001395.2 NM_001243609.1 NM_001243610.1 NM_001243611.1 NM_001243612.1 NM_001243613.1 NM_018640.4

Unigene Cluster for LMO3:

LIM domain only 3 (rhombotin-like 2)

Hs.504908 [show with all ESTs]

Unigene Representative Sequence: NM_018640

18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):

ENST00000441439(uc001rdk.2 uc009zii.2 uc010shz.2 uc001rdn.2 uc009zij.2 uc001rdo.2 uc009zik.2)

ENST00000447609(uc001rdl.2) ENST00000320122(uc001rdj.2) ENST00000396205

ENST00000453727 ENST00000540848 ENST00000541589 ENST00000535535 ENST00000537304

ENST00000541764 ENST00000534946 ENST00000424192 ENST00000540445 ENST00000541846

ENST00000536172 ENST00000544754 ENST00000539534 ENST00000546281

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LMO3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO3
		8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO3 (see all 104):
		hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LMO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMO3 (see all 4) OriGene shRNA RFP: LMO3 OriGene siRNA: LMO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LMO3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LMO3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LMO3 (NM_001001395)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LMO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LMO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO3

Additional cDNA sequence:

AB044745.1 AB044746.1 AF258348.1 AK095595.1 AK294474.1 AK294651.1 AK294909.1 AK308594.1

AK308826.1 AK308896.1 AK312418.1 AK316021.1 AL050152.1 AL050188.1 BC026311.1 BC050085.1

L31955.1 NR_045012.1 NR_045013.1 NR_045014.1

22 DOTS entries:

DT.416029 DT.95353026 DT.121188522 DT.100816645 DT.121188390 DT.91744212 DT.100816646 DT.95162724

DT.100800163 DT.121188362 DT.97799010 DT.97782060 DT.95255368 DT.121188388 DT.91736550 DT.97789982

DT.121188359 DT.121188371 DT.121188408 DT.121188435 DT.121188512 DT.95371368

24/174 AceView cDNA sequences (see all 174):

CA391958 F12110 NM_001001395 F09748 BX327807 BM985191 AL050152 CA441846

F04210 CA391959 NM_018640 BE702200 AW005977 CR598247 AL050188 CR611918

BE702203 F09744 Z41566 AA256963 BX371685 CB152360 AA773303 BM970491

GeneLoc Exon Structure

5/32 Alternative Splicing Database (ASD) splice patterns (SP) for LMO3 (see all 32) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·
SP1:							-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-
SP2:																	-		-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-
SP3:																	-		-		-		-		-		-		-		-		-		-		-		-				-		-		-		-		-
SP4:																													-		-		-		-		-		-				-		-		-		-		-
SP5:																															-		-		-		-		-				-		-		-		-		-

ExUns:	16b	·	16c	^	17a	·	17b	·	17c	·	17d	^	18	^	19a	·	19b	·	19c	·	19d	^	20a	·	20b	·	20c	·	20d	·	20e	^	21a	·	21b	·	21c	·	21d	·	21e	·	21f	·	21g	·	21h	·	21i
SP1:	-		-								-		-		-
SP2:	-		-				-		-		-		-		-		-		-		-
SP3:	-		-								-		-		-		-		-		-
SP4:	-		-				-		-		-		-		-		-		-		-
SP5:	-		-								-		-		-		-		-		-

ECgene alternative splicing isoforms for LMO3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LMO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATCGTGAA

About this image

LMO3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Posterior foregut-like cells (A scalable, suspensi...)

HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)

Bone

See LMO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LMO3

SOURCE GeneReport for Unigene cluster: Hs.504908

SABiosciences Custom PCR Arrays for LMO3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LMO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LMO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LMO3 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LMO3¹	LIM domain only 3 (rhombotin-like 2)	90.8(n) 100(a)		418179 XM_416410.3 XP_416410.3
lizard (Anolis carolinensis)	Reptilia	LMO3⁶	--	88(a)	1 ↔ 1	GL343336.1(519720-583607)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6611²	Xenopus laevis transcription facotr XLMO1 (XLMO1) mRNA, more	85.33(n)		U94991.1
zebrafish (Danio rerio)	Actinopterygii	lmo3¹	LIM domain only 3	81.61(n) 99.31(a)		553774 NM_001020739.1 NP_001018575.1
fruit fly (Drosophila melanogaster)	Insecta	Bx⁶	Beadex	25(a)	1 → many	X(18428696-18466842)

ENSEMBL Gene Tree for LMO3 (if available)
TreeFam Gene Tree for LMO3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LMO3 gene

LMO2² ISL1² LHX2² LHX9² LMX1B² LMO1² LHX5² LMO4²

LHX6² LHX1² LMX1A² LHX4² LHX3² LHX8² ISL2²

18/27 SIMAP similar genes for LMO3 using alignment to 12 protein entries: LMO3_HUMAN (see all proteins) (see all similar genes):

LMO1 LHx4 LMO4 LMO2 LHX4 ISL1

LHX3 LMX1A LHX1 ISL2 LHX9 LMX1B

LHX6 LHX2 ABLIM2 LHX8 WTIP LDB3

LMO3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113309676^1,2		--	16469615(+)	`CTAAAC/TATTAC`	10	--	ds500¹		1		CSA	2
rs12811757^1,2	C,H	--	16469961(+)	`TCTTAG/TGAAGG`	10	--	ut3¹ nc-transcript-varianttrp³		6		NS EA NA	600
rs1062744^1,2	H	--	16470320(-)	`TTTTTC/TTTTTA`	10	--	ut3¹ nc-transcript-varianttrp³		2		MN NS	300
rs73322814^1,2	C,	--	16472006(+)	`TAACAC/AGAACA`	10	--	ut3¹ nc-transcript-variant		1		WA	2
rs111970892^1,2	F	--	16472816(+)	`GTTTCG/ACATGG`	10	--	int¹		1		CSA	4
rs71539438^1,2	C,	--	16472818(+)	`TTCGCA/GTGGTA`	10	--	int¹		0	--	--	--	--
rs77407823^1,2		--	16472986(+)	`AAAGAC/TGACTT`	10	--	int¹		0	--	--	--	--
rs79833725^1,2	F,	--	16473506(+)	`CAATGT/CTTTTA`	10	--	int¹		1		WA	118
rs79984994^1,2	F	--	16474111(+)	`GCACAG/TACTAT`	10	--	int¹		1		NA	4
rs12300297^1,2	F,H,	--	16475179(+)	`TATTTA/TACAAA`	10	--	int¹		5		NS EA WA	528

HapMap Linkage Disequilibrium report for LMO3 (16701307 - 16763528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LMO3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LMO3 for disorders           About GeneDecksing

OMIM gene information: 180386    OMIM disorders: --

5 diseases for LMO3:    About MalaCards

neuronitis t-cell leukemia leukemia ataxia

neuroblastoma

Human Genome Epidemiology (HuGE) Navigator: LMO3 (1 document)

Export disorders for LMO3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LMO3 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with LMO3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. (PubMed id 11489251)^{1, 3} Shi J.... Xie Y. (2001)
The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. (PubMed id 1507224)^{1, 2} Foroni L.... Rabbitts T.H. (1992)
LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PubMed id 15930276)^{1, 9} Aoyama M....Nakagawara A. (2005)
LMO3 interacts with p53 and inhibits its transcriptio nal activity. (PubMed id 19995558)^{1, 9} Larsen S....Nakagawara A. (2010)
Genome-wide analysis of DNA methylation and the gene e xpression change in lung cancer. (PubMed id 22011669)¹ Kwon Y.J....Park J.H. (2012)
Oncogenic LMO3 collaborates with HEN2 to enhance neur oblastoma cell growth through transactivation of Mash1. (PubMed id 21573214)¹ Isogai E....Nakagawara A. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55885	HGNC: 6643	AceView: LMO3	Ensembl:ENSG00000048540	euGenes: HUgn55885
ECgene: LMO3	H-InvDB: LMO3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LMO3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LMO3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LMO3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LMO3 gene:
Search GeneIP for patents involving LMO3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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