Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LMO3 Gene

protein-coding   GIFtS: 54
GCID: GC12M016701

LIM Domain Only 3 (Rhombotin-Like 2)


(Previous symbol: RBTNL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
LIM Domain Only 3 (Rhombotin-Like 2)1 2     Rhom-32
RBTNL21 2 3 5     LIM Domain Only Protein 32
RHOM32 3 5     rhombotin-32
Neuronal-Specific Transcription Factor DAT12 3     LMO-33
RBTN32 3     Rhombotin-33

External Ids:    HGNC: 66431   Entrez Gene: 558852   Ensembl: ENSG000000485407   OMIM: 1803865   UniProtKB: Q8TAP43   
ORGUL members:         

Export aliases for LMO3 gene to outside databases

Previous GC identifers: GC12U990051 GC12M016593 GC12M016594 GC12M016469


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LMO3 Gene:
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene
is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been
reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for LMO3 Gene:
LMO3 (LIM domain only 3 (rhombotin-like 2)) is a protein-coding gene. Diseases associated with LMO3 include t-cell leukemia, and neuronitis. An important paralog of this gene is LMO4.

Gene Wiki entry for LMO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMO3 gene promoter:
         GR   IRF-7A   aMEF-2   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LMO3 promoter sequence
   Search Chromatin IP Primers for LMO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13

LMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M016701:  view genomic region     (about GC identifiers)

Start:
16,701,307 bp from pter      End:
16,763,528 bp from pter
Size:
62,222 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4 (See protein sequence)
Recommended Name: LIM domain only protein 3  
Size: 145 amino acids; 16594 Da
Secondary accessions: B4DG90 B4DH35 Q58A66 Q58A67 Q8N974 Q9UDD5
Alternative splicing: 4 isoforms:  Q8TAP4-1   Q8TAP4-2   Q8TAP4-3   Q8TAP4-4   

Explore the universe of human proteins at neXtProt for LMO3: NX_Q8TAP4

Explore proteomics data for LMO3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LMO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001001395.1  NP_001230538.1  NP_001230539.1  NP_001230540.1  NP_001230541.1  NP_001230542.1  NP_061110.2  

    ENSEMBL proteins: 
     ENSP00000412479   ENSP00000413703   ENSP00000312856   ENSP00000379508   ENSP00000404386  
     ENSP00000445751   ENSP00000440948   ENSP00000446115   ENSP00000440099   ENSP00000437890  
     ENSP00000439275   ENSP00000404656   ENSP00000442786   ENSP00000444393   ENSP00000440885  
     ENSP00000439900   ENSP00000443807   ENSP00000442713   ENSP00000445193   ENSP00000438187  
     ENSP00000441360   ENSP00000445504   ENSP00000444269   ENSP00000439989   ENSP00000446095  
     ENSP00000446463   ENSP00000261169   ENSP00000346689  

    LMO3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for LMO3
    OriGene Protein Over-expression Lysate for LMO3
    OriGene MassSpec for LMO3
    OriGene Custom Protein Services for LMO3
    GenScript Custom Purified and Recombinant Proteins Services for LMO3
    Novus Biologicals LMO3 Protein
    Novus Biologicals LMO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    LMO3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LMO3
    OriGene Custom Antibody Services for LMO3
    Novus Biologicals LMO3 Antibodies
    Abcam antibodies for LMO3
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for LMO3
    LSBio Antibodies in human, mouse, rat for LMO3

    LMO3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMO3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMO3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q8TAP4

    ProtoNet protein and cluster: Q8TAP4

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4
    Similarity: Contains 2 LIM zinc-binding domains


    LMO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for LMO3:
    Lim domain only 3

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    LMO3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMO3:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lmo3):
     mortality/aging  normal 

    LMO3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lmo3tm1Thr for LMO3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMO3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMO3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMO3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMO3

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMO3:
    hsa-mir-335-5p (MIRT017853)

    Block miRNA regulation of human, mouse, rat LMO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO3 (see all 104):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLMO3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMO3
    Predesigned siRNA for gene silencing in human, mouse, rat LMO3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMO3

    Clone
    Products:
         
    OriGene clones in human, mouse for LMO3 (see all 11)
    OriGene ORF clones in mouse, rat for LMO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LMO3 (NM_001001395)
    Sino Biological Human cDNA Clone for LMO3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMO3
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMO3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LMO3
    Interactions:

        Search GeneGlobe Interaction Network for LMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMO3 (Q8TAP43 ENSP000003466894) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB1Q86U703, ENSP000003924664I2D: score=5 STRING: ENSP00000392466
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    GABPB1Q065473, ENSP000003702594I2D: score=4 STRING: ENSP00000370259
    MBIPQ9NS733, ENSP000003244444I2D: score=4 STRING: ENSP00000324444
    ZBTB43O432983, ENSP000003625564I2D: score=4 STRING: ENSP00000362556
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    LMO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMO3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LMO3 gene (7 alternative transcripts): 
    NM_001001395.2  NM_001243609.1  NM_001243610.1  NM_001243611.1  NM_001243612.1  NM_001243613.1  NM_018640.4  

    Unigene Cluster for LMO3:

    LIM domain only 3 (rhombotin-like 2)
    Hs.504908  [show with all ESTs]
    Unigene Representative Sequence: NM_018640
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000441439(uc001rdk.2 uc009zii.2 uc010shz.2 uc001rdn.2 uc009zij.2 uc001rdo.2 uc009zik.2)
    ENST00000447609(uc001rdl.2) ENST00000320122(uc001rdj.2) ENST00000396205
    ENST00000453727 ENST00000540848 ENST00000541589 ENST00000535535 ENST00000537304
    ENST00000541764 ENST00000534946 ENST00000424192 ENST00000540445 ENST00000541846
    ENST00000536172 ENST00000544754 ENST00000539534 ENST00000546281
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO3 (see all 104):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLMO3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LMO3
    Predesigned siRNA for gene silencing in human, mouse, rat LMO3
    Clone
    Products:
         
    OriGene clones in human, mouse for LMO3 (see all 11)
    OriGene ORF clones in mouse, rat for LMO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LMO3 (NM_001001395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMO3
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO3
      QuantiTect SYBR Green Assays in human, mouse, rat LMO3
      QuantiFast Probe-based Assays in human, mouse, rat LMO3

    Additional mRNA sequence: 

    AB044745.1 AB044746.1 AF258348.1 AK095595.1 AK294474.1 AK294651.1 AK294909.1 AK308594.1 
    AK308826.1 AK308896.1 AK312418.1 AK316021.1 AL050152.1 AL050188.1 BC026311.1 BC050085.1 
    L31955.1 NR_045012.1 NR_045013.1 NR_045014.1 

    22 DOTS entries:

    DT.416029  DT.95353026  DT.121188522  DT.100816645  DT.121188390  DT.91744212  DT.100816646  DT.95162724 
    DT.100800163  DT.121188362  DT.97799010  DT.97782060  DT.95255368  DT.121188388  DT.91736550  DT.97789982 
    DT.121188359  DT.121188371  DT.121188408  DT.121188435  DT.121188512  DT.95371368 

    Selected AceView cDNA sequences (see all 174):

    AW005977 CR598247 F12110 F09748 R01058 CR611918 BX371685 Z41566 
    AL050152 AA493766 NM_001001395 AI289796 BX327807 CA391959 F12106 NM_018640 
    BQ960563 AA773303 AI363121 AL698741 BM970491 AI369819 CB152360 AA256963 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LMO3 (see all 32)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP2:                                                  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP3:                                                  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP4:                                                                                      -     -     -     -     -     -           -     -     -     -     -   
    SP5:                                                                                            -     -     -     -     -           -     -     -     -     -   

    ExUns: 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d ^ 20a · 20b · 20c · 20d · 20e ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g · 21h · 21i
    SP1:  -     -                       -     -     -                                                                                                         
    SP2:  -     -           -     -     -     -     -     -     -     -                                                                                       
    SP3:  -     -                       -     -     -     -     -     -                                                                                       
    SP4:  -     -           -     -     -     -     -     -     -     -                                                                                       
    SP5:  -     -                       -     -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for LMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LMO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCGTGAA
    LMO3 Expression
    About this image


    LMO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             N2/LSB/S/F8/CHIR-induced cells
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
             Midbrain dopaminergic-like neurons
     
     NULL (Uncategorized)
             Neural rosettes
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced MEL2 cells
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
    LMO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504908
        Custom PCR Arrays for LMO3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMO3
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO3
    QuantiTect SYBR Green Assays in human, mouse, rat LMO3
    QuantiFast Probe-based Assays in human, mouse, rat LMO3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LMO3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmo35 LIM domain only 3   --   6 (69.02 cM) 138362918 
    chicken
    (Gallus gallus)
    Aves LMO36
    LIM domain only 3 (rhombotin-like 2)
    82(a)
    1 ↔ 1
    1(63504395-63561066)
    lizard
    (Anolis carolinensis)
    Reptilia LMO36
    LIM domain only 3 (rhombotin-like 2)
    78(a)
    1 ↔ 1
    GL343336.1(519720-585523)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66112 Xenopus laevis transcription facotr XLMO1 (XLMO1) mRNA, more 85.33(n)    U94991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmo36
    LIM domain only 3
    76(a)
    1 ↔ 1
    4(11677247-11743817) ENSDARG00000008720
    fruit fly
    (Drosophila melanogaster)
    Insecta Bx6
    Beadex
    22(a)
    1 → many
    X(18428696-18466842)


    ENSEMBL Gene Tree for LMO3 (if available)
    TreeFam Gene Tree for LMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LMO3 gene
    LMO42  LMO22  LMO12  
    Selected SIMAP similar genes for LMO3 using alignment to 11 protein entries:     LMO3_HUMAN (see all proteins) (see all similar genes):
    LMO1    LHx4    LMO4    LMO2    LHX4    ISL1
    LHX3    LMX1A    LHX1    LMX1B    ISL2    LHX9
    LHX8    LHX6    LHX2    ABLIM2    WTIP    LIMK1

    LMO3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LMO3 (see all 958)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820051901,2
    --16487397(+) TATATA/GTATAT 10 -- int10--------
    rs681226541,2
    C--16512940(+) TGCTT-/GATGTC 10 -- int10--------
    rs665327301,2
    C--16527556(+) GTTTG-/AAAAAA 10 -- ut51 int1 us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1141138441,2
    C,F--16568580(+) CATGGC/GATGTT 10 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1440496791,2
    C--16568588(+) GTTTTA/GCTACA 10 -- ds50010--------
    rs1812747551,2
    --16568635(+) AACATA/CTCTTC 10 -- ds50010--------
    rs1853941441,2
    --16568656(+) TAGAAC/TTGAGT 10 -- ds50010--------
    rs1899624291,2
    --16568746(+) TCACCG/TAAAAT 10 -- ds50010--------
    rs1473384931,2
    --16568754(+) AATTTA/GTATAA 10 -- ds50010--------
    rs1133096761,2
    F--16568862(+) CTAAAC/TATTAC 10 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for LMO3 (16701307 - 16763528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832339CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMO3
    DNA2.0 Custom Variant and Variant Library Synthesis for LMO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 180386    OMIM disorders: --

    10 diseases for LMO3:    
    About MalaCards
    t-cell leukemia    neuronitis    leukemia    neuroblastoma
    lung adenocarcinoma    ataxia    lung cancer    adenocarcinoma
    malaria    endotheliitis


    LMO3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LMO3
    Human Genome Epidemiology (HuGE) Navigator: LMO3 (1 document)

    Export disorders for LMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LMO3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with LMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. (PubMed id 11489251)1, 3 Shi J.... Xie Y. (Brain Res. 2001)
    4. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. (PubMed id 1507224)1, 2 Foroni L.... Rabbitts T.H. (J. Mol. Biol. 1992)
    5. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PubMed id 15930276)1, 9 Aoyama M....Nakagawara A. (Cancer Res. 2005)
    6. LMO3 interacts with p53 and inhibits its transcriptional activity. (PubMed id 19995558)1, 9 Larsen S....Nakagawara A. (Biochem. Biophys. Res. Commun. 2010)
    7. Human but not mouse adipogenesis is critically dependent on LMO3. (PubMed id 23823477)1 Lindroos J....Bilban M. (Cell Metab. 2013)
    8. Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. (PubMed id 23322301)1 Watanabe H....Meyerson M. (amp 2013)
    9. Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (PubMed id 22011669)1 Kwon Y.J....Park J.H. (J Thorac Oncol 2012)
    10. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. (PubMed id 21124317)4 Wang K....Maris J.M. (Nature 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55885 HGNC: 6643 AceView: LMO3 Ensembl:ENSG00000048540 euGenes: HUgn55885
    ECgene: LMO3 H-InvDB: LMO3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LMO3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LMO3 gene:
    Search GeneIP for patents involving LMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LMO3   OriGene RNAi products in human, mouse, rat for LMO3  
     OriGene qPCR primer pairs and template standards for LMO3   OriGene Protein Over-expression Lysate for LMO3  
     OriGene MassSpec something-or-other for LMO3   OriGene clones in human, mouse for LMO3  
     OriGene qSTAR qPCR primer pairs in human, mouse for LMO3   OriGene Purified Protein for LMO3  
     OriGene ORF clones in mouse, rat for LMO3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LMO3   OriGene Custom Protein Services for LMO3  

     
     
     Block miRNA regulation of human, mouse, rat LMO3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LMO3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMO3 Predesigned siRNA for gene silencing in human, mouse, rat LMO3
     QuantiFast Probe-based Assays in human, mouse, rat LMO3 QuantiTect SYBR Green Assays in human, mouse, rat LMO3
     Custom PCR Arrays for LMO3 Search Chromatin IP Primers for LMO3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO3  Search GeneGlobe Interaction Network for LMO3
     Regulatory tfbs in LMO3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LMO3 GenScript cDNA clones with any tag delivered in your preferred vector for LMO3
     GenScript Custom Assay Services for LMO3 GenScript Custom overexpressing Cell Line Services for LMO3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LMO3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for LMO3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LMO3 antibodies
     LMO3 proteins
     LMO3 lysates
     Antibodies for LMO3
     See all of Abcam's Antibodies, Kits and Proteins for LMO3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for LMO3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3
     SwitchGear 3'UTR luciferase reporter plasmids for LMO3
     SwitchGear Promoter luciferase reporter plasmids for LMO3
     Search ThermoFisher Antibodies for LMO3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMO3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMO3
     LSBio Antibodies in human, mouse, rat for LMO3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LMO3 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4