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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMO3 Gene

protein-coding   GIFtS: 54
GCID: GC12M016701

LIM Domain Only 3 (Rhombotin-Like 2)


(Previous symbol: RBTNL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
LIM Domain Only 3 (Rhombotin-Like 2)1 2     Rhom-32
RBTNL21 2 3 5     LIM Domain Only Protein 32
RHOM32 3 5     rhombotin-32
Neuronal-Specific Transcription Factor DAT12 3     LMO-33
RBTN32 3     Rhombotin-33

External Ids:    HGNC: 66431   Entrez Gene: 558852   Ensembl: ENSG000000485407   OMIM: 1803865   UniProtKB: Q8TAP43   
ORGUL members:         
NONCODE14:n411728      

Export aliases for LMO3 gene to outside databases

Previous GC identifers: GC12U990051 GC12M016593 GC12M016594 GC12M016469


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMO3 Gene:
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene
is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been
reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for LMO3 Gene: 
LMO3 (LIM domain only 3 (rhombotin-like 2)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with LMO3 include t-cell leukemia, and neuronitis. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is ISL1.

Gene Wiki entry for LMO3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMO3 gene promoter:
         GR   IRF-7A   aMEF-2   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LMO3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LMO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p13

LMO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M016701:  view genomic region     (about GC identifiers)

Start:
16,701,307 bp from pter      End:
16,763,528 bp from pter
Size:
62,222 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4 (See protein sequence)
Recommended Name: LIM domain only protein 3  
Size: 145 amino acids; 16594 Da
Secondary accessions: B4DG90 B4DH35 Q58A66 Q58A67 Q8N974 Q9UDD5
Alternative splicing: 4 isoforms:  Q8TAP4-1   Q8TAP4-2   Q8TAP4-3   Q8TAP4-4   

Explore the universe of human proteins at neXtProt for LMO3: NX_Q8TAP4

Explore proteomics data for LMO3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAP4

  • LMO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMO3 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001001395.1  NP_001230538.1  NP_001230539.1  NP_001230540.1  NP_001230541.1  NP_001230542.1  NP_061110.2  

    ENSEMBL proteins: 
     ENSP00000412479   ENSP00000413703   ENSP00000312856   ENSP00000379508   ENSP00000404386  
     ENSP00000445751   ENSP00000440948   ENSP00000446115   ENSP00000440099   ENSP00000437890  
     ENSP00000439275   ENSP00000404656   ENSP00000442786   ENSP00000444393   ENSP00000440885  
     ENSP00000439900   ENSP00000443807   ENSP00000442713   ENSP00000445193   ENSP00000438187  
     ENSP00000441360   ENSP00000445504   ENSP00000444269   ENSP00000439989   ENSP00000446095  
     ENSP00000446463   ENSP00000261169   ENSP00000346689  

    Human Recombinant Protein Products for LMO3: 
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    Novus Biologicals LMO3 Protein
    Novus Biologicals LMO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    LMO3 Antibody Products: 
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    Abcam antibodies for LMO3
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    LSBio Antibodies in human, mouse, rat for LMO3 

    Assay Products for LMO3: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q8TAP4

    ProtoNet protein and cluster: Q8TAP4

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LMO3_HUMAN, Q8TAP4
    Similarity: Contains 2 LIM zinc-binding domains


    LMO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for LMO3:
    Lim domain only 3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    LMO3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMO3:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lmo3):
     mortality/aging  normal 

    LMO3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lmo3tm1Thr for LMO3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMO3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMO3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMO3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMO3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO3
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO3 (see all 104):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLMO3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3
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                         Customized lentivirus expression plasmids for stable overexpression of LMO3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LMO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/34 Interacting proteins for LMO3 (Q8TAP43 ENSP000003466894) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB1Q86U703, ENSP000003924664I2D: score=5 STRING: ENSP00000392466
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    GABPB1Q065473, ENSP000003702594I2D: score=4 STRING: ENSP00000370259
    MBIPQ9NS733, ENSP000003244444I2D: score=4 STRING: ENSP00000324444
    ZBTB43O432983, ENSP000003625564I2D: score=4 STRING: ENSP00000362556
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    LMO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMO3

    Search CenterWatch for drugs/clinical trials and news about LMO3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LMO3 gene (7 alternative transcripts): 
    NM_001001395.2  NM_001243609.1  NM_001243610.1  NM_001243611.1  NM_001243612.1  NM_001243613.1  NM_018640.4  

    Unigene Cluster for LMO3:

    LIM domain only 3 (rhombotin-like 2)
    Hs.504908  [show with all ESTs]
    Unigene Representative Sequence: NM_018640
    18/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34):
    ENST00000441439(uc001rdk.2 uc009zii.2 uc010shz.2 uc001rdn.2 uc009zij.2 uc001rdo.2 uc009zik.2)
    ENST00000447609(uc001rdl.2) ENST00000320122(uc001rdj.2) ENST00000396205
    ENST00000453727 ENST00000540848 ENST00000541589 ENST00000535535 ENST00000537304
    ENST00000541764 ENST00000534946 ENST00000424192 ENST00000540445 ENST00000541846
    ENST00000536172 ENST00000544754 ENST00000539534 ENST00000546281
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO3
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO3 (see all 104):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p
    SwitchGear 3'UTR luciferase reporter plasmidLMO3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LMO3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO3
    Clone
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    OriGene clones in human, mouse for LMO3 (see all 13)
    OriGene ORF clones in mouse, rat for LMO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LMO3 (NM_001001395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO3
    Sirion Biotech Customized lentivirus for stable overexpression of LMO3 
                         Customized lentivirus expression plasmids for stable overexpression of LMO3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMO3
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMO3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO3

    Additional mRNA sequence: 

    AB044745.1 AB044746.1 AF258348.1 AK095595.1 AK294474.1 AK294651.1 AK294909.1 AK308594.1 
    AK308826.1 AK308896.1 AK312418.1 AK316021.1 AL050152.1 AL050188.1 BC026311.1 BC050085.1 
    L31955.1 NR_045012.1 NR_045013.1 NR_045014.1 

    22 DOTS entries:

    DT.416029  DT.95353026  DT.121188522  DT.100816645  DT.121188390  DT.91744212  DT.100816646  DT.95162724 
    DT.100800163  DT.121188362  DT.97799010  DT.97782060  DT.95255368  DT.121188388  DT.91736550  DT.97789982 
    DT.121188359  DT.121188371  DT.121188408  DT.121188435  DT.121188512  DT.95371368 

    24/174 AceView cDNA sequences (see all 174):

    AL050188 BX327807 F12110 F04210 AA493766 CB152360 AL050152 F09748 
    BM970491 AA256963 AW005977 AI369819 AA773303 AI363121 CA391959 R01058 
    BM985191 Z41566 AI289796 F09744 AL698741 CR611918 BE702203 NM_018640 

    GeneLoc Exon Structure

    5/32 Alternative Splicing Database (ASD) splice patterns (SP) for LMO3 (see all 32)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
    SP1:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP2:                                                  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP3:                                                  -     -     -     -     -     -     -     -     -     -     -     -           -     -     -     -     -   
    SP4:                                                                                      -     -     -     -     -     -           -     -     -     -     -   
    SP5:                                                                                            -     -     -     -     -           -     -     -     -     -   

    ExUns: 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d ^ 20a · 20b · 20c · 20d · 20e ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g · 21h · 21i
    SP1:  -     -                       -     -     -                                                                                                         
    SP2:  -     -           -     -     -     -     -     -     -     -                                                                                       
    SP3:  -     -                       -     -     -     -     -     -                                                                                       
    SP4:  -     -           -     -     -     -     -     -     -     -                                                                                       
    SP5:  -     -                       -     -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for LMO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMO3 expression in normal human tissues (normalized intensities)      LMO3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATCGTGAA
    LMO3 Expression
    About this image


    LMO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Human Preadipocyte-visceral (HPA-v)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Neurons   
     
     Mesenchymal Stem Cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Smooth Muscle (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   

    See LMO3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMO3

    SOURCE GeneReport for Unigene cluster: Hs.504908
        SABiosciences Custom PCR Arrays for LMO3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMO3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmo31 , 5 LIM domain only 31, 5 93.33(n)1
    100(a)1
      6 (69.02 cM)5
    1095931  NM_207222.21  NP_997105.11 
     1383629185 
    chicken
    (Gallus gallus)
    Aves LMO31 LIM domain only 3 (rhombotin-like 2) 90.8(n)
    100(a)
      418179  XM_416410.3  XP_416410.3 
    lizard
    (Anolis carolinensis)
    Reptilia LMO36
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343336.1(519720-585523)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66112 Xenopus laevis transcription facotr XLMO1 (XLMO1) mRNA, more 85.33(n)    U94991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmo31 LIM domain only 3 81.61(n)
    99.31(a)
      553774  NM_001020739.1  NP_001018575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bx6
    Beadex
    22(a)
    1 → many
    X(18428696-18466842)


    ENSEMBL Gene Tree for LMO3 (if available)
    TreeFam Gene Tree for LMO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMO3 gene
    ISL12  LMO22  LHX22  LHX92  LMX1B2  LHX52  LMO12  LHX62  
    LMO42  LHX12  LMX1A2  LHX32  LHX42  LHX82  ISL22  
    18/26 SIMAP similar genes for LMO3 using alignment to 11 protein entries:     LMO3_HUMAN (see all proteins) (see all similar genes):
    LMO1    LHx4    LMO4    LMO2    LHX4    ISL1
    LHX3    LMX1A    ISL2    LHX1    LMX1B    LHX9
    LHX6    LHX2    ABLIM2    LHX8    WTIP    LIMK1

    LMO3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/958 SNPs in LMO3 are shown (see all 958)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820051901,2
    --16487397(+) TATATA/GTATAT 10 -- int10--------
    rs681226541,2
    C--16512940(+) TGCTT-/GATGTC 10 -- int10--------
    rs665327301,2
    C--16527556(+) GTTTG-/AAAAAA 10 -- ut51 int1 us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1141138441,2
    C,F--16568580(+) CATGGC/GATGTT 10 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1440496791,2
    C--16568588(+) GTTTTA/GCTACA 10 -- ds50010--------
    rs1812747551,2
    --16568635(+) AACATA/CTCTTC 10 -- ds50010--------
    rs1853941441,2
    --16568656(+) TAGAAC/TTGAGT 10 -- ds50010--------
    rs1899624291,2
    --16568746(+) TCACCG/TAAAAT 10 -- ds50010--------
    rs1473384931,2
    --16568754(+) AATTTA/GTATAA 10 -- ds50010--------
    rs1133096761,2
    F--16568862(+) CTAAAC/TATTAC 10 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for LMO3 (16701307 - 16763528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMO3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832339CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180386    OMIM disorders: --

    5 diseases for LMO3:    About MalaCards
    t-cell leukemia    neuronitis    leukemia    neuroblastoma
    lung cancer


    LMO3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LMO3
    Human Genome Epidemiology (HuGE) Navigator: LMO3 (1 document)

    Export disorders for LMO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMO3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with LMO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization. (PubMed id 11489251)1, 3 Shi J.... Xie Y. (2001)
    4. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. (PubMed id 1507224)1, 2 Foroni L.... Rabbitts T.H. (1992)
    5. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PubMed id 15930276)1, 9 Aoyama M....Nakagawara A. (2005)
    6. LMO3 interacts with p53 and inhibits its transcriptio nal activity. (PubMed id 19995558)1, 9 Larsen S....Nakagawara A. (2010)
    7. Integrated cistromic and expression analysis of amplif ied NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptiona l target. (PubMed id 23322301)1 Watanabe H....Meyerson M. (2013)
    8. Genome-wide analysis of DNA methylation and the gene e xpression change in lung cancer. (PubMed id 22011669)1 Kwon Y.J....Park J.H. (2012)
    9. Integrative genomics identifies LMO1 as a neuroblasto ma oncogene. (PubMed id 21124317)4 Wang K....Maris J.M. (2011)
    10. Oncogenic LMO3 collaborates with HEN2 to enhance neur oblastoma cell growth through transactivation of Mash1. (PubMed id 21573214)1 Isogai E....Nakagawara A. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55885 HGNC: 6643 AceView: LMO3 Ensembl:ENSG00000048540 euGenes: HUgn55885
    ECgene: LMO3 H-InvDB: LMO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMO3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LMO3 gene:
    Search GeneIP for patents involving LMO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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