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Aliases for LMO3 Gene

Aliases for LMO3 Gene

  • LIM Domain Only 3 (Rhombotin-Like 2) 2 3
  • RBTNL2 3 4 6
  • RHOM3 3 4 6
  • Neuronal-Specific Transcription Factor DAT1 3 4
  • Rhombotin-3 3 4
  • RBTN3 3 4
  • LIM Domain Only Protein 3 3
  • Rhom-3 3
  • LMO-3 4

External Ids for LMO3 Gene

Previous Symbols for LMO3 Gene

  • RBTNL2

Summaries for LMO3 Gene

Entrez Gene Summary for LMO3 Gene

  • The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for LMO3 Gene

LMO3 (LIM Domain Only 3 (Rhombotin-Like 2)) is a Protein Coding gene. An important paralog of this gene is LMO2.

Gene Wiki entry for LMO3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO3 Gene

Genomics for LMO3 Gene

Genomic Location for LMO3 Gene

Start:
16,548,372 bp from pter
End:
16,610,594 bp from pter
Size:
62,223 bases
Orientation:
Minus strand

Genomic View for LMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO3 Gene

Regulatory Elements for LMO3 Gene

Proteins for LMO3 Gene

  • Protein details for LMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAP4-LMO3_HUMAN
    Recommended name:
    LIM domain only protein 3
    Protein Accession:
    Q8TAP4
    Secondary Accessions:
    • B4DG90
    • B4DH35
    • Q58A66
    • Q58A67
    • Q8N974
    • Q9UDD5

    Protein attributes for LMO3 Gene

    Size:
    145 amino acids
    Molecular mass:
    16594 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMO3 Gene

Proteomics data for LMO3 Gene at MOPED

Post-translational modifications for LMO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMO3 Gene

Domains for LMO3 Gene

Protein Domains for LMO3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

LMO3_HUMAN
Domain:
  • Contains 2 LIM zinc-binding domains.:
    • Q8TAP4
genes like me logo Genes that share domains with LMO3: view

No data available for Gene Families for LMO3 Gene

Function for LMO3 Gene

Molecular function for LMO3 Gene

GENATLAS Biochemistry: Lim domain only 3

Gene Ontology (GO) - Molecular Function for LMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LMO3: view

Phenotypes for LMO3 Gene

MGI mutant phenotypes for LMO3:
inferred from 2 alleles
GenomeRNAi human phenotypes for LMO3:
genes like me logo Genes that share phenotypes with LMO3: view

Animal Models for LMO3 Gene

MGI Knock Outs for LMO3:

miRNA for LMO3 Gene

miRTarBase miRNAs that target LMO3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LMO3 Gene

Localization for LMO3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMO3 Gene COMPARTMENTS Subcellular localization image for LMO3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23823477
genes like me logo Genes that share ontologies with LMO3: view

Pathways for LMO3 Gene

SuperPathways for LMO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IDA 23823477
GO:0045600 positive regulation of fat cell differentiation IMP 23823477
GO:0070373 negative regulation of ERK1 and ERK2 cascade IDA 23823477
genes like me logo Genes that share ontologies with LMO3: view

No data available for Pathways by source for LMO3 Gene

Transcripts for LMO3 Gene

Unigene Clusters for LMO3 Gene

LIM domain only 3 (rhombotin-like 2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMO3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
SP1: - - - - - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - - - -
SP20: - - - - - -
SP21: - - - - -
SP22: - - - - -
SP23: - - - - - - - - - - - - - - - - - - - - - - - - -
SP24: - -
SP25: - -
SP26: - - - - - - - - - - - - - - - - - - - - - - -
SP27: - - - - - - - - - - - - - - - - -
SP28: - - - -
SP29: -
SP30:
SP31: - - - - -
SP32:

ExUns: 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d ^ 20a · 20b · 20c · 20d · 20e ^ 21a · 21b · 21c · 21d · 21e · 21f · 21g · 21h · 21i
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - - -
SP16: - - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - - - -
SP19: - - -
SP20: - - - - - - - -
SP21: - - - - - - - - - -
SP22: - - - - - - - -
SP23: - - - - - - - -
SP24: - - - - - - - -
SP25: - - - - - - - - - -
SP26: - - - - - -
SP27: - -
SP28: - - - - - - - - - -
SP29: - - - - - - - -
SP30: - - - - - - -
SP31: - -
SP32:

Relevant External Links for LMO3 Gene

GeneLoc Exon Structure for
LMO3
ECgene alternative splicing isoforms for
LMO3

Expression for LMO3 Gene

mRNA expression in normal human tissues for LMO3 Gene

mRNA differential expression in normal tissues according to GTEx for LMO3 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.8), Brain - Amygdala (4.4), Brain - Frontal Cortex (BA9) (4.1), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LMO3 Gene

SOURCE GeneReport for Unigene cluster for LMO3 Gene Hs.504908

genes like me logo Genes that share expressions with LMO3: view

Orthologs for LMO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMO3 37
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LMO3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMO3 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmo3 16
Lmo3 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMO3 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMO3 37
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMO3 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMO3 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6611 36
zebrafish
(Danio rerio)
Actinopterygii lmo3 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010391 36
  • 69.05 (n)
  • 77.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bx 37
  • 22 (a)
OneToMany
Species with no ortholog for LMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMO3 Gene

ENSEMBL:
Gene Tree for LMO3 (if available)
TreeFam:
Gene Tree for LMO3 (if available)

Paralogs for LMO3 Gene

Paralogs for LMO3 Gene

genes like me logo Genes that share paralogs with LMO3: view

Variants for LMO3 Gene

Sequence variations from dbSNP and Humsavar for LMO3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs15747 -- 16,549,633(-) TTTTT(C/T)TTGAT utr-variant-3-prime, nc-transcript-variant
rs726261 -- 16,551,589(-) AGCAA(C/G)TCATC intron-variant
rs766066 -- 16,578,287(-) GAGTA(A/G)TTTAT intron-variant
rs987581 -- 16,597,448(-) TTTTA(C/T)TTGTG intron-variant
rs989231 -- 16,588,566(+) GGAAA(C/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMO3 Gene

Variant ID Type Subtype PubMed ID
nsv832339 CNV Gain 17160897

Relevant External Links for LMO3 Gene

HapMap Linkage Disequilibrium report
LMO3

Disorders for LMO3 Gene

Relevant External Links for LMO3

Genetic Association Database (GAD)
LMO3
Human Genome Epidemiology (HuGE) Navigator
LMO3
genes like me logo Genes that share disorders with LMO3: view

No data available for UniProtKB/Swiss-Prot for LMO3 Gene

Publications for LMO3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. (PMID: 15930276) Aoyama M. … Nakagawara A. (Cancer Res. 2005) 3 23
  4. LMO3 interacts with p53 and inhibits its transcriptional activity. (PMID: 19995558) Larsen S. … Nakagawara A. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. (PMID: 1507224) Foroni L. … Rabbitts T.H. (J. Mol. Biol. 1992) 3 4

Products for LMO3 Gene

Sources for LMO3 Gene

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