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Aliases for LMO2 Gene

Aliases for LMO2 Gene

  • LIM Domain Only 2 2 3 5
  • Rhombotin-Like 1 2 2 3
  • T-Cell Translocation Protein 2 3 4
  • T-Cell Translocation Gene 2 2 3
  • Cysteine-Rich Protein TTG-2 3 4
  • LIM Domain Only Protein 2 3 4
  • RBTNL1 3 4
  • LMO-2 3 4
  • RBTN2 3 4
  • RHOM2 3 4
  • TTG2 3 4
  • LIM Domain Only 2 (Rhombotin-Like 1) 3
  • Rhombotin 2 3

External Ids for LMO2 Gene

Previous HGNC Symbols for LMO2 Gene

  • RBTNL1

Previous GeneCards Identifiers for LMO2 Gene

  • GC11M035411
  • GC11M034557
  • GC11M033919
  • GC11M033844
  • GC11M033836
  • GC11M033576

Summaries for LMO2 Gene

Entrez Gene Summary for LMO2 Gene

  • LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

GeneCards Summary for LMO2 Gene

LMO2 (LIM Domain Only 2) is a Protein Coding gene. Diseases associated with LMO2 include lymphoblastic leukemia and t-cell leukemia. Among its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include chromatin binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is LMO1.

UniProtKB/Swiss-Prot for LMO2 Gene

  • Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Gene Wiki entry for LMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO2 Gene

Genomics for LMO2 Gene

Regulatory Elements for LMO2 Gene

Enhancers for LMO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMO2 on UCSC Golden Path with GeneCards custom track

Promoters for LMO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LMO2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LMO2 gene promoter:

Genomic Location for LMO2 Gene

Chromosome:
11
Start:
33,858,576 bp from pter
End:
33,892,289 bp from pter
Size:
33,714 bases
Orientation:
Minus strand

Genomic View for LMO2 Gene

Genes around LMO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO2 Gene

Proteins for LMO2 Gene

  • Protein details for LMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25791-RBTN2_HUMAN
    Recommended name:
    Rhombotin-2
    Protein Accession:
    P25791
    Secondary Accessions:
    • Q9HD58

    Protein attributes for LMO2 Gene

    Size:
    158 amino acids
    Molecular mass:
    18358 Da
    Quaternary structure:
    • Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A.
    SequenceCaution:
    • Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAA43430.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LMO2 Gene

    Alternative splice isoforms for LMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMO2 Gene

Proteomics data for LMO2 Gene at MOPED

Post-translational modifications for LMO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LMO2 Gene

Antibody Products

No data available for DME Specific Peptides for LMO2 Gene

Domains & Families for LMO2 Gene

Gene Families for LMO2 Gene

Protein Domains for LMO2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LMO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25791

UniProtKB/Swiss-Prot:

RBTN2_HUMAN :
  • The second LIM zinc-binding domain interacts with KDM5A.
Domain:
  • The second LIM zinc-binding domain interacts with KDM5A.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LMO2: view

Function for LMO2 Gene

Molecular function for LMO2 Gene

GENATLAS Biochemistry:
LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)
UniProtKB/Swiss-Prot Function:
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Gene Ontology (GO) - Molecular Function for LMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 16314316
GO:0001102 RNA polymerase II activating transcription factor binding IPI 16314316
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0070888 E-box binding IDA 16314316
genes like me logo Genes that share ontologies with LMO2: view
genes like me logo Genes that share phenotypes with LMO2: view

Animal Models for LMO2 Gene

MGI Knock Outs for LMO2:

Animal Model Products

miRNA for LMO2 Gene

miRTarBase miRNAs that target LMO2

Transcription Factor Targets for LMO2 Gene

Selected GeneGlobe predicted Target genes for LMO2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for LMO2 Gene

Localization for LMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMO2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMO2 Gene COMPARTMENTS Subcellular localization image for LMO2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for LMO2 Gene

Pathways & Interactions for LMO2 Gene

genes like me logo Genes that share pathways with LMO2: view

Pathways by source for LMO2 Gene

SIGNOR curated interactions for LMO2 Gene

Activates:

Gene Ontology (GO) - Biological Process for LMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 1923511
genes like me logo Genes that share ontologies with LMO2: view

Drugs & Compounds for LMO2 Gene

(2) Drugs for LMO2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LMO2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LMO2: view

Transcripts for LMO2 Gene

Unigene Clusters for LMO2 Gene

LIM domain only 2 (rhombotin-like 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMO2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for LMO2 Gene

GeneLoc Exon Structure for
LMO2
ECgene alternative splicing isoforms for
LMO2

Expression for LMO2 Gene

mRNA expression in normal human tissues for LMO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMO2 Gene

This gene is overexpressed in Fetal Liver (48.0) and Placenta (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMO2 Gene



SOURCE GeneReport for Unigene cluster for LMO2 Gene Hs.34560

genes like me logo Genes that share expression patterns with LMO2: view

Protein tissue co-expression partners for LMO2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LMO2 Gene

Orthologs for LMO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMO2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC609006 35
  • 90.76 (n)
  • 96.39 (a)
LMO2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmo2 35
  • 92.27 (n)
  • 96.82 (a)
Lmo2 16
Lmo2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMO2 35
  • 98.53 (n)
  • 97.79 (a)
LMO2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmo2 35
  • 91.82 (n)
  • 96.82 (a)
cow
(Bos Taurus)
Mammalia LMO2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMO2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMO2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMO2 35
  • 89.87 (n)
  • 100 (a)
LMO2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMO2 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmo2 35
  • 83.01 (n)
  • 95.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia lmo2-A 35
zebrafish
(Danio rerio)
Actinopterygii lmo2 35
  • 79.78 (n)
  • 90.32 (a)
lmo2 36
  • 89 (a)
OneToOne
Species with no ortholog for LMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMO2 Gene

ENSEMBL:
Gene Tree for LMO2 (if available)
TreeFam:
Gene Tree for LMO2 (if available)

Paralogs for LMO2 Gene

Paralogs for LMO2 Gene

(16) SIMAP similar genes for LMO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LMO2: view

Variants for LMO2 Gene

Sequence variations from dbSNP and Humsavar for LMO2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs746481 -- 33,883,825(-) GTAGC(C/T)CTGTG intron-variant
rs746482 -- 33,883,776(-) tcatc(A/G)cccat intron-variant
rs746483 -- 33,883,739(-) ATTAG(A/G)GTGTT intron-variant
rs879414 -- 33,862,112(-) AATGC(C/T)TCATT intron-variant
rs883495 -- 33,887,062(+) TCCCA(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMO2 Gene

Variant ID Type Subtype PubMed ID
nsv509398 CNV Insertion 20534489
nsv526555 CNV Loss 19592680
nsv519717 CNV Loss 19592680
esv1115754 CNV Insertion 17803354

Variation tolerance for LMO2 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMO2 Gene

HapMap Linkage Disequilibrium report
LMO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO2 Gene

Disorders for LMO2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for LMO2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • acute lymphocytic leukemia
t-cell leukemia
  • leukemia t-cell
acute t cell leukemia
  • precursor t lymphoblastic leukemia
diffuse large b-cell lymphoma
  • large b cell diffuse lymphoma
follicular lymphoma
  • lymphoma, follicular
- elite association - COSMIC cancer census association via MalaCards
Search LMO2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RBTN2_HUMAN
  • Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Genatlas disease for LMO2 Gene

acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)

Relevant External Links for LMO2

Genetic Association Database (GAD)
LMO2
Human Genome Epidemiology (HuGE) Navigator
LMO2
Tumor Gene Database (TGDB):
LMO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMO2
genes like me logo Genes that share disorders with LMO2: view

Publications for LMO2 Gene

  1. T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PMID: 9129143) Mao S. … Goorha R.M. (Oncogene 1997) 3 4 23 67
  2. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PMID: 2034676) Boehm T. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 23
  3. Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes. (PMID: 20346173) Sun W. … Zhu T.H. (J. Biomed. Sci. 2010) 3 23
  4. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. (PMID: 19487290) Appert A. … Rabbitts T. (Cancer Res. 2009) 3 23
  5. The transcription factor LMO2 is a robust marker of vascular endothelium and vascular neoplasms and selected other entities. (PMID: 19141387) Gratzinger D. … Natkunam Y. (Am. J. Clin. Pathol. 2009) 3 23

Products for LMO2 Gene

Sources for LMO2 Gene

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