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LMO2 Gene

protein-coding   GIFtS: 65
GCID: GC11M033880

LIM Domain Only 2 (Rhombotin-Like 1)


(Previous symbol: RBTNL1)
  See LMO2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Domain Only 2 (Rhombotin-Like 1)1 2     LMO-22 3
RBTNL11 2 3 5     RBTN22 3
RHOM22 3 5     LIM Domain Only Protein 22 3
TTG22 3 5     T-Cell Translocation Protein 22 3
Rhombotin-Like 11 2     Rhombotin 22
T-Cell Translocation Gene 21 2     rhombotin-22
Cysteine-Rich Protein TTG-22 3     

External Ids:    HGNC: 66421   Entrez Gene: 40052   Ensembl: ENSG000001353637   OMIM: 1803855   UniProtKB: P257913   

Export aliases for LMO2 gene to outside databases

Previous GC identifers: GC11M035411 GC11M034557 GC11M033919 GC11M033844 GC11M033836 GC11M033576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMO2 Gene:
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2
protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2
transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster
(11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative
splicing results in multiple transcript variants encoding different isoforms.(provided by RefSeq, Nov 2008)

GeneCards Summary for LMO2 Gene:
LMO2 (LIM domain only 2 (rhombotin-like 1)) is a protein-coding gene. Diseases associated with LMO2 include gamma chain deficiency, and acute t cell leukemia. GO annotations related to this gene include chromatin binding and RNA polymerase II activating transcription factor binding. An important paralog of this gene is LMO4.

UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
Function: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid
precursors in an immature state

Gene Wiki entry for LMO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMO2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LMO2 promoter sequence
   Search Chromatin IP Primers for LMO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

LMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033880:  view genomic region     (about GC identifiers)

Start:
33,880,122 bp from pter      End:
33,913,836 bp from pter
Size:
33,715 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791 (See protein sequence)
Recommended Name: Rhombotin-2  
Size: 158 amino acids; 18358 Da
Subunit: Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein
TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A
Sequence caution: Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH73973.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAA43430.1; Type=Frameshift; Positions=Several;
4 PDB 3D structures from and Proteopedia for LMO2:
2XJY (3D)        2XJZ (3D)        2YPA (3D)        4KFZ (3D)    
Secondary accessions: Q9HD58
Alternative splicing: 3 isoforms:  P25791-1   P25791-3   P25791-4   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for LMO2: NX_P25791

Explore proteomics data for LMO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LMO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135787.1  NP_001135788.1  NP_005565.2  

    ENSEMBL proteins: 
     ENSP00000401967   ENSP00000379175   ENSP00000257818  

    LMO2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals LMO2 Protein
    Novus Biologicals LMO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LMO2 

     
    antibodies-online proteins for LMO2 (7 products) 

     
    antibodies-online peptides for LMO2

    LMO2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMO2
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    antibodies-online antibodies for LMO2 (97 products) 

    LMO2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMO2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for LMO2 
    antibodies-online kits for LMO2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P25791

    ProtoNet protein and cluster: P25791

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
    Domain: The second LIM zinc-binding domain interacts with KDM5A
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with LMO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBTN2_HUMAN, P25791
    Function: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid
    precursors in an immature state

         Genatlas biochemistry entry for LMO2:
    LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric
    DNA-binding complex for the generation of hematopoietic lineages and angiogenesis (in mice)

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA16314316
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA16314316
    GO:0001102RNA polymerase II activating transcription factor binding IPI16314316
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA16314316
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA16314316
         
    Find genes that share ontologies with LMO2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LMO2:
     Increased gamma-H2AX phosphory  Proliferating cells 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lmo2):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 
     renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with LMO2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lmo2tm1Thr for LMO2

       genOway: Develop your customized and physiologically relevant rodent model for LMO2

    miRNA
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    miRTarBase miRNAs that target LMO2:
    hsa-mir-223-3p (MIRT000130)

    Block miRNA regulation of human, mouse, rat LMO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO2 (see all 12):
    hsa-miR-3163 hsa-miR-3149 hsa-miR-362-3p hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmidLMO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMO2
    Predesigned siRNA for gene silencing in human, mouse, rat LMO2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): LMO2 (NM_005574)
    Sino Biological Human cDNA Clone for LMO2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10074 VA6-13144) for LMO2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBTN2_HUMAN, P25791: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IDA16314316
    GO:0043234protein complex ----

    Find genes that share ontologies with LMO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LMO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with LMO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for LMO2):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMO2: 
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMO2 (P257911, 2, 3 ENSP000002578184) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206376Q96KQ72, 3MINT-67674 I2D: score=5 
    ENSG00000232045Q96KQ72, 3MINT-67674 I2D: score=5 
    ENSG00000236759Q96KQ72, 3MINT-67674 I2D: score=5 
    ENSG00000238134Q96KQ72, 3MINT-67674 I2D: score=5 
    STAT1P422242, 3, ENSP000003543944MINT-66556 I2D: score=5 STRING: ENSP00000354394
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS1923511
    GO:0035162embryonic hemopoiesis IEA--
    GO:0042789mRNA transcription from RNA polymerase II promoter IDA16314316
    GO:0045647negative regulation of erythrocyte differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16314316

    Find genes that share ontologies with LMO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMO2 (RBTN2)

    3 Novoseek inferred chemical compound relationships for LMO2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tal 2 83.2 3 7957052 (2), 14975618 (1)
    zinc 2.95 2 9209374 (1), 7544155 (1)
    tyrosine 0 1 19635185 (1)



    Find genes that share compounds with LMO2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LMO2 gene (3 alternative transcripts): 
    NM_001142315.1  NM_001142316.1  NM_005574.3  

    Unigene Cluster for LMO2:

    LIM domain only 2 (rhombotin-like 1)
    Hs.34560  [show with all ESTs]
    Unigene Representative Sequence: X61118
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464025(uc001mvc.3) ENST00000411482(uc001mvd.3) ENST00000395833(uc001mve.3)
    ENST00000257818(uc010rel.2 uc010rem.2) ENST00000465614 ENST00000493667

    miRNA
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    Block miRNA regulation of human, mouse, rat LMO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO2 (see all 12):
    hsa-miR-3163 hsa-miR-3149 hsa-miR-362-3p hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmidLMO2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LMO2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): LMO2 (NM_005574)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO2
      QuantiTect SYBR Green Assays in human, mouse, rat LMO2
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    Flow Cytometry
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    Additional mRNA sequence: 

    AF257211.1 AK127915.1 BC034041.1 BC035607.1 BC042426.1 BC073973.1 X61118.1 

    9 DOTS entries:

    DT.454509  DT.100707202  DT.100775807  DT.444566  DT.95188348  DT.95161059  DT.97808158  DT.87015072 
    DT.87008922 

    Selected AceView cDNA sequences (see all 151):

    CR625714 AI052253 AA280651 CR614368 AI302050 AA907895 AA742325 AA447059 
    AI247832 CR604507 BF340978 AW235360 BX373857 AI359899 AF257211 BC042426 
    BU676547 AA464544 AW440868 AI590050 AA962429 AI803492 AI653053 BM690599 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LMO2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                -                 -                                             
    SP2:                                                                    -                           
    SP3:                                                                    -     -                     
    SP4:              -     -     -     -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for LMO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACGCATT
    LMO2 Expression
    About this image


    LMO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 7 entries
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)    fully expand to see all 2 entries
             Primitive Erythrocytes Extraembryonic Blood Islands
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Yolk Sac (Extraembryonic Tissues)
             Erythroid Progenitor Cells Definitive Yolk Sac
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
    LMO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34560
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMO2: 
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for LMO2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO2
    QuantiTect SYBR Green Assays in human, mouse, rat LMO2
    QuantiFast Probe-based Assays in human, mouse, rat LMO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LMO2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmo21 , 5 LIM domain only 21, 5 92.27(n)1
    96.82(a)1
      2 (54.46 cM)5
    169091  NM_001142335.11  NP_001135807.11 
     1039579865 
    chicken
    (Gallus gallus)
    Aves LMO21 LIM domain only 2 (rhombotin-like 1) 89.87(n)
    100(a)
      374129  NM_204271.1  NP_989602.1 
    lizard
    (Anolis carolinensis)
    Reptilia LMO26
    LIM domain only 2 (rhombotin-like 1)
    99(a)
    1 ↔ 1
    GL343283.1(1034262-1044640)
    African clawed frog
    (Xenopus laevis)
    Amphibia lmo2-A2 LIM domain only 2 (rhombotin-like 1) 82.25(n)    AF374473.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmo22 LIM domain only 2 81.53(n)   30332  AF191560.1 


    ENSEMBL Gene Tree for LMO2 (if available)
    TreeFam Gene Tree for LMO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LMO2 gene
    LMO42  LMO32  LMO12  
    16 SIMAP similar genes for LMO2 using alignment to 1 protein entry:     RBTN2_HUMAN:
    LMO1    LMO3    LHX5    ISL2    LHX4    LMO4
    LHX1    ISL1    LHX9    LMX1A    LHX3    LMX1B
    LHX6    LHX8    LHX2    LIMK1

    Find genes that share paralogs with LMO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LMO2 (see all 613)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819535871,2
    C--33879634(+) AACACA/GCAAAC 3 -- ds50010--------
    rs1379714691,2
    --33879850(+) TCTTGC/GCTTCC 3 -- ds50010--------
    rs71061121,2
    C,F,A,H--33879892(+) ATATTG/TTACAA 3 -- ds500122Minor allele frequency- T:0.40NS EA NA WA 2350
    rs1495052661,2
    C--33880004(+) ACACAG/TAAGTT 3 -- ds50010--------
    rs758268151,2
    C,F--33880086(+) CATCCC/TAAATT 3 -- ds50012Minor allele frequency- T:0.08NA EA 240
    rs1440649081,2
    --33880109(+) CAAATA/GAACAA 3 -- ds50010--------
    rs360294841,2
    C--33880157(+) AGCTGT/-TTTTT 3 -- ut311Minor allele frequency- -:0.50NA 2
    rs1848053591,2
    --33880175(+) CACACA/GACAAA 3 -- ut310--------
    rs758973921,2
    C,F--33880309(+) GCATTA/GCTTTA 3 -- ut311Minor allele frequency- G:0.00CSA 1
    rs1888772481,2
    --33880428(+) AAAGAA/TTGGCC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for LMO2 (33880122 - 33913836 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LMO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1115754CNV Insertion17803354
    nsv509398CNV Insertion20534489
    nsv526555CNV Loss19592680
    nsv519717CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMO2
    DNA2.0 Custom Variant and Variant Library Synthesis for LMO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180385    OMIM disorders: --

    UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
  • Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic
    leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD

  • 4 diseases for LMO2:    
    About MalaCards
    gamma chain deficiency    acute t cell leukemia    lymphoblastic leukemia    norrie disease

    3 diseases from the University of Copenhagen DISEASES database for LMO2:
    Gamma chain deficiency     Leukemia     Lymphoma

    Find genes that share disorders with LMO2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LMO2 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 87.5 53 7731686 (3), 16873670 (3), 9020185 (3), 17268520 (3) (see all 20)
    severe combined immunodeficiency, x-linked 84.4 4 19440365 (1), 19461887 (1), 17726455 (1), 18227842 (1)
    leukemia t-cell 77.8 18 14645513 (2), 12727888 (1), 19440365 (1), 15994290 (1) (see all 15)
    leukemogenesis 77 6 17726455 (1), 7475267 (1), 7544155 (1), 17268520 (1)
    leukemia 60.5 36 19440365 (4), 19461887 (4), 17910069 (2), 19171877 (1) (see all 15)
    acute leukemia 52.6 11 9209362 (2), 10197599 (1), 9872335 (1), 15198727 (1) (see all 8)
    lymphoma lymphoblastic 40 2 9116269 (1)
    severe combined immunodeficiency 37.7 3 19171877 (1), 15190153 (1), 15195349 (1)
    premalignant 12.5 1 14564000 (1)
    tumors 8.58 18 19487290 (6), 9116269 (1), 20016842 (1), 2034676 (1) (see all 9)

    Genatlas disease: LMO2
    acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)

    Genetic Association Database (GAD): LMO2
    Human Genome Epidemiology (HuGE) Navigator: LMO2 (9 documents)
    Tumor Gene Database (TGDB): LMO2

    Export disorders for LMO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMO2 gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with LMO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PubMed id 9129143)1, 2, 9 Mao S.... Goorha R.M. (Oncogene 1997)
    2. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PubMed id 16314316)1, 2, 9 Han C.... Peng X. (Nucleic Acids Res. 2005)
    3. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PubMed id 2034676)1, 3, 9 Boehm T....Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    4. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (PubMed id 1923511)1, 2, 9 Royer-Pokora B.... Ludwig W.D. (Oncogene 1991)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    7. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    8. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    9. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    10. Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development. (PubMed id 19336552)1, 4 Morton L.M....Hartge P. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4005 HGNC: 6642 AceView: LMO2 Ensembl:ENSG00000135363 euGenes: HUgn4005
    ECgene: LMO2 Kegg: 4005 H-InvDB: LMO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LMO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LMO2 gene:
    Search GeneIP for patents involving LMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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