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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMO2 Gene

protein-coding   GIFtS: 64
GCID: GC11M033880

LIM domain only 2 (rhombotin-like 1)


(Previous symbol: RBTNL1)
 Explore 34 diseases affiliated with
LMO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LMO2    

Aliases
for LMO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
LIM Domain Only 2 (Rhombotin-Like 1)1 2     LIM Domain Only Protein 22 3
RBTNL11 2 3 5     T-Cell Translocation Protein 22 3
RHOM21 2 3 5     Rhombotin 22
TTG21 2 3 5     Rhombotin-21
RBTN21 2 3     Rhombotin-Like 12
Cysteine-Rich Protein TTG-22 3     T-Cell Translocation Gene 22
LMO-22 3     

External Ids:    HGNC: 66421   Entrez Gene: 40052   Ensembl: ENSG000001353637   OMIM: 1803855   UniProtKB: P257913   

Export aliases for LMO2 gene to outside databases

Previous GC identifers: GC11M035411 GC11M034557 GC11M033919 GC11M033844 GC11M033836 GC11M033576


Summaries
for LMO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LMO2:
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has
a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is
located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell
acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript
variants encoding different isoforms.(provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
Function: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid
precursors in an immature state

Gene Wiki entry for LMO2


Genomic Views
for LMO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMO2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LMO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LMO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

LMO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033880:  view genomic region     (about GC identifiers)

Start:
 33,880,122 bp from pter      End:
 33,913,836 bp from pter
Size:
 33,715 bases      Orientation:
 minus strand

Proteins
for LMO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791 (See protein sequence)
Recommended Name: Rhombotin-2  
Size: 158 amino acids; 18358 Da
Subunit: Interacts via its LIM domains with ELF2 and LDB1. Also interacts with basic helix-loop-helix protein TAL1/SCL
and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and KDM5A
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAH73973.1;
Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAA43430.1; Type=Frameshift; Positions=Several;
2 PDB 3D structures from and Proteopedia for LMO2:
2XJY (3D)        2XJZ (3D)    
Secondary accessions: Q9HD58
Alternative splicing: 3 isoforms:  P25791-1   P25791-3   P25791-4   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for LMO2: NX_P25791

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25791

    • LMO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001135787.1  NP_001135788.1  NP_005565.2  

    ENSEMBL proteins: 
     ENSP00000257818   ENSP00000379175   ENSP00000401967  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins (see all 4): LMO2
    OriGene Protein Over-expression Lysate (see all 4): LMO2
    OriGene Custom Protein Services for LMO2 
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    Novus Biologicals LMO2 Protein
    Novus Biologicals LMO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LMO2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005667transcription factor complex IDA16314316
    GO:0043234protein complex ----


    LMO2 for ontologies           About GeneDecksing



    LMO2 Antibody Products: 
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    OriGene Antibodies (see all 5): LMO2
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    Abcam antibodies for LMO2 
    Uscn Antibodies for LMO2
    ThermoFisher Antibody for LMO2

    Assay Products for LMO2: 
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    GenScript Custom Assay Services for LMO2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LMO2

    Protein Domains /
    Families
    for LMO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LMO2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P25791

    ProtoNet protein and cluster: P25791

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
    Domain: The second LIM zinc-binding domain interacts with KDM5A
    Similarity: Contains 2 LIM zinc-binding domains


    Function
    for LMO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
    Function: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid
    precursors in an immature state

         Genatlas biochemistry entry for LMO2:
    LIM domain only 2,rhombotin 2,involved in association with LMO1 (and others),in the formation of multimeric DNA-binding
    complex for the generation of hematopoietic lineages and angiogenesis (in mice)

    miRNA
    Products:            		miRTarBase miRNAs that target LMO2:
    hsa-mir-223 (MIRT000130)

    OriGene 3'-UTR Clone (see all 3): LMO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO2 (see all 12):
    hsa-miR-3163 hsa-miR-3149 hsa-miR-362-3p hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmid: LMO2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMO2 (see all 7)
    OriGene shRNA RFP: LMO2
    OriGene siRNA: LMO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LMO2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LMO2 (see all 9)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): LMO2 (NM_005574)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO2 

    Cell Line
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    Search LifeMap BioReagents cell lines for LMO2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO2

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA16314316
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA16314316
    GO:0001102RNA polymerase II activating transcription factor binding IPI16314316
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA16314316
    GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA16314316


    LMO2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for LMO2:
     Increased gamma-H2AX phosphory  Proliferating cells 

    Animal Models:
         Mouse knock-out Lmo2tm1Thr for LMO2
         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lmo2):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  integument  liver/biliary system  mortality/aging  nervous system 
     renal/urinary system  tumorigenesis 

    LMO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LMO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LMO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for LMO2 (P257911, 2, 3 ENSP000002578184) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT1P422242, 3, ENSP000003543944MINT-66556 I2D: score=5 STRING: ENSP00000354394
    RLIMQ9NVW22, 3, ENSP000002535714MINT-17113 I2D: score=2 STRING: ENSP00000253571
    MLLT4P551962, 3, ENSP000003836234MINT-16706 MINT-16707 I2D: score=3 STRING: ENSP00000383623
    MAPRE2Q155552, 3, ENSP000003002494MINT-66036 I2D: score=5 STRING: ENSP00000300249
    MAPRE3Q9UPY82, 3, ENSP000002331214MINT-67170 I2D: score=6 STRING: ENSP00000233121
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS1923511
    GO:0035162embryonic hemopoiesis IEA--
    GO:0042789mRNA transcription from RNA polymerase II promoter IDA16314316
    GO:0045647negative regulation of erythrocyte differentiation IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA16314316


    LMO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LMO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LMO2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMO2
    3 Novoseek chemical compound relationships for LMO2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tal 2 83.2 3 7957052 (2), 14975618 (1)
    zinc 2.95 2 9209374 (1), 7544155 (1)
    tyrosine 0 1 19635185 (1)

    Search CenterWatch for drugs/clinical trials and news about LMO2 / RBTN2 

    Transcripts
    for LMO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LMO2 gene (3 alternative transcripts): 
    NM_001142315.1  NM_001142316.1  NM_005574.3  

    Unigene Cluster for LMO2:

    LIM domain only 2 (rhombotin-like 1)
    Hs.34560  [show with all ESTs]
    Unigene Representative Sequence: X61118
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257818(uc010rel.2 uc010rem.2) ENST00000395833(uc001mve.3)
    ENST00000411482(uc001mvd.3) ENST00000464025(uc001mvc.3) ENST00000465614
    ENST00000493667

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): LMO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMO2
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate LMO2 (see all 12):
    hsa-miR-3163 hsa-miR-3149 hsa-miR-362-3p hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmid: LMO2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMO2 (see all 7)
    OriGene shRNA RFP: LMO2
    OriGene siRNA: LMO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMO2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LMO2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): LMO2 (NM_005574)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO2

    Additional cDNA sequence: 

    AF257211.1 AK127915.1 BC034041.1 BC035607.1 BC042426.1 BC073973.1 X61118.1 

    9 DOTS entries:

    DT.454509  DT.100707202  DT.100775807  DT.444566  DT.95188348  DT.95161059  DT.97808158  DT.87015072 
    DT.87008922 

    24/151 AceView cDNA sequences (see all 151):

    AI247832 AA447059 AW235360 BF340978 AA907895 AA280651 CR614368 AA742325 
    CR604507 AI052253 CR625714 AI302050 AW072304 BX111749 AI359920 AI476739 
    AI809534 AI086112 BI762566 CA418759 AA913108 AA830322 AA961623 BF446801 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LMO2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                -                 -                                             
    SP2:                                                                    -                           
    SP3:                                                                    -     -                     
    SP4:              -     -     -     -                                                               
    SP5:                                                                                                


    ECgene alternative splicing isoforms for LMO2

    Expression
    for LMO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGACGCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LMO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive Hematopoietic Stem CellsBlood
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    Yolk SacDefinitive Yolk SacErythroid Progenitor CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Primitive StreakPosterior Primitive StreakHemangioblastsBlood, Endothelium
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Blast colony cells (Generation and expan...)
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See LMO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMO2

    SOURCE GeneReport for Unigene cluster: Hs.34560
        SABiosciences Expression via Pathway-Focused PCR Arrays including LMO2: 
              Leukemia in human mouse rat
              Lymphoma in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMO2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO2

    Orthologs
    for LMO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LMO2 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LMO21 LIM domain only 2 (rhombotin-like 1) 89.87(n)
    100(a)    		   374129  NM_204271.1  NP_989602.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LMO26
    		 --
    		 99(a)
    		 1 ↔ 1
    		 GL343283.1(1034263-1044625)
    African clawed frog
    (Xenopus laevis)    		 Amphibia lmo2-A2 LIM domain only 2 (rhombotin-like 1) 82.25(n)    AF374473.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lmo22 LIM domain only 2 81.53(n)   30332  AF191560.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 19(a)
    		 possible ortholog
    		 Group7.32(1913-3300)


    ENSEMBL Gene Tree for LMO2 (if available)
    TreeFam Gene Tree for LMO2 (if available) 

    Paralogs
    for LMO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMO2 gene
    ISL12  LHX22  LHX92  LMX1B2  LMO12  LHX52  LMO42  LHX62  
    LHX12  LMX1A2  LMO32  LHX42  LHX32  LHX82  ISL22  
    18/19 SIMAP similar genes for LMO2 using alignment to 1 protein entry:     RBTN2_HUMAN(see all similar genes):
    LMO1    LMO3    LHX5    ISL2    LHX4    LMO4
    LHX1    ISL1    LHX9    LMX1A    LHX3    LMX1B
    LHX6    LHX8    LHX2    LIMK1    ABLIM2    ABLIM3

    LMO2 for paralogs           About GeneDecksing



    Genomic Variants
    for LMO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/626 NCBI SNPs in LMO2 are shown (see all 626)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1819535871,2
    		--33879634(+) AACACA/GCAAAC 3 -- ds50010--------
    rs1379714691,2
    		--33879850(+) TCTTGC/GCTTCC 3 -- ds50010--------
    rs71061121,2
    		C,F,A,H,--33879892(+) ATATTG/TTACAA 3 -- ds500122Minor allele frequency- T:0.40NS EA NA WA 2350
    rs1495052661,2
    		--33880004(+) ACACAG/TAAGTT 3 -- ds50010--------
    rs758268151,2
    		F,--33880086(+) CATCCC/TAAATT 3 -- ds50012Minor allele frequency- T:0.08NA EA 240
    rs1440649081,2
    		--33880109(+) CAAATA/GAACAA 3 -- ds50010--------
    rs1419401521,2
    		C,--33880156(+) AGCTG-/TTTTTT 3 -- ut310--------
    rs360294841,2
    		C--33880158(+) TTTTTT/-CTACA 3 -- ut311Minor allele frequency- -:0.50NA 2
    rs1848053591,2
    		--33880175(+) CACACA/GACAAA 3 -- ut310--------
    rs758973921,2
    		--33880309(+) GCATTA/GCTTTA 3 -- ut311Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for LMO2 (33880122 - 33913836 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LMO2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LMO2
    DNA2.0 Custom Variant and Variant Library Synthesis for LMO2

    Disorders / Diseases
    for LMO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LMO2 for disorders           About GeneDecksing

    OMIM gene information: 180385    OMIM disorders: --

    UniProtKB/Swiss-Prot: RBTN2_HUMAN, P25791
  • Note=A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia
    • (T-ALL). Translocation t(11,14)(p13;q11) with TCRD

    20/34 diseases for LMO2 (see all 34):    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    severe combined immunodeficiency    leukemia
    gamma chain deficiency    diffuse large b-cell lymphoma    combined immunodeficiency    b-cell lymphomas
    non-hodgkin lymphoma    norrie disease    hodgkin's lymphoma    follicular lymphoma
    acute leukemia    lymphoblastic lymphoma    immunodeficiency    t-cell leukemia
    rheumatoid arthritis    hemangioma    acute t cell leukemia    retinoblastoma

    3 diseases from the University of Copenhagen DISEASES database for LMO2:
    Gamma chain deficiency     Leukemia     Lymphoma

    10/16 Novoseek disease relationships for LMO2 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 87.5 53 7731686 (3), 16873670 (3), 9020185 (3), 17268520 (3) (see all 20)
    severe combined immunodeficiency, x-linked 84.4 4 19440365 (1), 19461887 (1), 17726455 (1), 18227842 (1)
    leukemia t-cell 77.8 18 14645513 (2), 12727888 (1), 19440365 (1), 15994290 (1) (see all 15)
    leukemogenesis 77 6 17726455 (1), 7475267 (1), 7544155 (1), 17268520 (1)
    leukemia 60.5 36 19440365 (4), 19461887 (4), 17910069 (2), 19171877 (1) (see all 15)
    acute leukemia 52.6 11 9209362 (2), 10197599 (1), 9872335 (1), 15198727 (1) (see all 8)
    lymphoma lymphoblastic 40 2 9116269 (1)
    severe combined immunodeficiency 37.7 3 19171877 (1), 15190153 (1), 15195349 (1)
    premalignant 12.5 1 14564000 (1)
    tumors 8.58 18 19487290 (6), 9116269 (1), 20016842 (1), 2034676 (1) (see all 9)

    Genatlas disease: LMO2
    acute lymphoblastic leukemia (T-ALL),with translocations t(11;14)(p13;q11),t(7;11)(p35;p13)

    Human Genome Epidemiology (HuGE) Navigator: LMO2 (9 documents)
    Tumor Gene Database (TGDB): LMO2

    Export disorders for LMO2 gene to outside databases

    Publications
    for LMO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMO2 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with LMO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PubMed id 9129143)1, 2, 9 Mao S.... Goorha R.M. (1997)
    2. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. (PubMed id 16314316)1, 2, 9 Han C.... Peng X. (2005)
    3. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PubMed id 2034676)1, 3, 9 Boehm T....Rabbitts T.H. (1991)
    4. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). (PubMed id 1923511)1, 2, 9 Royer-Pokora B.... Ludwig W.D. (1991)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. LMO2 is a novel predictive marker for a better progno sis in pancreatic cancer. (PubMed id 19568416)1, 9 Nakata K....Tsuneyoshi M. (2009)
    7. Targeting LMO2 with a peptide aptamer establishes a n ecessary function in overt T-cell neoplasia. (PubMed id 19487290)1, 9 Appert A....Rabbitts T. (2009)
    8. [Abnormal expression of transcription factors LYL1 an d LMO2 and interaction between them in myeloid leukemia] (PubMed id 19671288)1, 9 Meng Y.S....Zhang Y.X. (2009)
    9. Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy. (PubMed id 17268520)1, 9 Pike-Overzet K....Staal F.J. (2007)
    10. Effect of LMO2 protein expression on survival in chro nic myeloid leukemia patients treated with imatinib mesylate. (PubMed id 19635185)1, 9 Sonmez M....Omay S.B. (2009)

    External Searches for LMO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing LMO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4005 HGNC: 6642 AceView: LMO2 Ensembl:ENSG00000135363 euGenes: HUgn4005
    ECgene: LMO2 H-InvDB: LMO2

    Other Databases showing LMO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LMO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for LMO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LMO2 gene:
    Search GeneIP for patents involving LMO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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