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Aliases for LMO1 Gene

Aliases for LMO1 Gene

  • LIM Domain Only 1 2 3 5
  • T-Cell Translocation Protein 1 3 4
  • Cysteine-Rich Protein TTG-1 3 4
  • LIM Domain Only Protein 1 3 4
  • Rhombotin 1 2 3
  • RBTN1 3 4
  • LMO-1 3 4
  • RHOM1 3 4
  • TTG1 3 4
  • LIM Domain Only 1 (Rhombotin 1) 3
  • T-Cell Translocation Gene 1 3

External Ids for LMO1 Gene

Previous HGNC Symbols for LMO1 Gene

  • RBTN1

Previous GeneCards Identifiers for LMO1 Gene

  • GC11M009030
  • GC11M008706
  • GC11M008204
  • GC11M008210
  • GC11M008202
  • GC11M007915

Summaries for LMO1 Gene

Entrez Gene Summary for LMO1 Gene

  • This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]

GeneCards Summary for LMO1 Gene

LMO1 (LIM Domain Only 1) is a Protein Coding gene. Diseases associated with LMO1 include T-Cell Leukemia and Lymphoblastic Leukemia. An important paralog of this gene is LMO2.

UniProtKB/Swiss-Prot for LMO1 Gene

  • May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Gene Wiki entry for LMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO1 Gene

Genomics for LMO1 Gene

Regulatory Elements for LMO1 Gene

Enhancers for LMO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMO1 Gene

8,224,304 bp from pter
8,268,716 bp from pter
44,413 bases
Minus strand

Genomic View for LMO1 Gene

Genes around LMO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO1 Gene

Proteins for LMO1 Gene

  • Protein details for LMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E9PSF5
    • Q4VBC5
    • Q8IXR0

    Protein attributes for LMO1 Gene

    156 amino acids
    Molecular mass:
    17828 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39512.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LMO1 Gene


neXtProt entry for LMO1 Gene

Proteomics data for LMO1 Gene at MOPED

Post-translational modifications for LMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LMO1 Gene

No data available for DME Specific Peptides for LMO1 Gene

Domains & Families for LMO1 Gene

Gene Families for LMO1 Gene

Protein Domains for LMO1 Gene


Suggested Antigen Peptide Sequences for LMO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LIM zinc-binding domains.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with LMO1: view

Function for LMO1 Gene

Molecular function for LMO1 Gene

GENATLAS Biochemistry:
LIM domain only 1,rhombotin 1,expressed in rhombomeres
UniProtKB/Swiss-Prot Function:
May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Gene Ontology (GO) - Molecular Function for LMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with LMO1: view
genes like me logo Genes that share phenotypes with LMO1: view

Animal Models for LMO1 Gene

MGI Knock Outs for LMO1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LMO1 Gene

Localization for LMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMO1 Gene

Subcellular locations from

Jensen Localization Image for LMO1 Gene COMPARTMENTS Subcellular localization image for LMO1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for LMO1 Gene

Pathways & Interactions for LMO1 Gene

SuperPathways for LMO1 Gene

No Data Available

SIGNOR curated interactions for LMO1 Gene


Gene Ontology (GO) - Biological Process for LMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 20855495
genes like me logo Genes that share ontologies with LMO1: view

No data available for Pathways by source for LMO1 Gene

Drugs & Compounds for LMO1 Gene

No Compound Related Data Available

Transcripts for LMO1 Gene

Unigene Clusters for LMO1 Gene

LIM domain only 1 (rhombotin 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMO1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -

Relevant External Links for LMO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMO1 Gene

mRNA expression in normal human tissues for LMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LMO1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.6), Skin - Not Sun Exposed (Suprapubic) (x6.1), Skin - Sun Exposed (Lower leg) (x4.3), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for LMO1 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMO1 Gene

SOURCE GeneReport for Unigene cluster for LMO1 Gene Hs.654426

mRNA Expression by UniProt/SwissProt for LMO1 Gene

Tissue specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
genes like me logo Genes that share expression patterns with LMO1: view

Protein tissue co-expression partners for LMO1 Gene

Primer Products

Orthologs for LMO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LMO1 35
  • 94.87 (n)
  • 98.08 (a)
LMO1 36
  • 98 (a)
(Canis familiaris)
Mammalia LMO1 35
  • 95.73 (n)
  • 100 (a)
LMO1 36
  • 100 (a)
(Mus musculus)
Mammalia Lmo1 35
  • 93.16 (n)
  • 98.72 (a)
Lmo1 16
Lmo1 36
  • 99 (a)
(Pan troglodytes)
Mammalia LMO1 35
  • 100 (n)
  • 100 (a)
LMO1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lmo1 35
  • 92.9 (n)
  • 98.71 (a)
(Monodelphis domestica)
Mammalia LMO1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia LMO1 36
  • 96 (a)
(Gallus gallus)
Aves LOC100858792 35
  • 84.83 (n)
  • 97.44 (a)
LMO1 36
  • 97 (a)
(Anolis carolinensis)
Reptilia LMO1 36
  • 94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32263 35
(Danio rerio)
Actinopterygii lmo1 35
  • 85.16 (n)
  • 98.06 (a)
lmo1 36
  • 98 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9759 35
fruit fly
(Drosophila melanogaster)
Insecta Bx 37
  • 79 (a)
Bx 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000731 35
  • 73.18 (n)
  • 75.78 (a)
(Oryza sativa)
Liliopsida Os.9021 35
Species with no ortholog for LMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMO1 Gene

Gene Tree for LMO1 (if available)
Gene Tree for LMO1 (if available)

Paralogs for LMO1 Gene

Paralogs for LMO1 Gene

genes like me logo Genes that share paralogs with LMO1: view

Variants for LMO1 Gene

Sequence variations from dbSNP and Humsavar for LMO1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs520756 -- 8,250,122(+) GCTTA(C/T)GATCA intron-variant
rs530589 -- 8,248,545(+) TCCAC(A/G)GAGGT intron-variant
rs538930 -- 8,242,899(+) GGGCC(A/C)TTCAA intron-variant
rs743630 -- 8,258,492(-) ACGAG(A/G)TTCAG intron-variant
rs897108 -- 8,268,520(-) aggcg(A/G)ccggc upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LMO1 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv896982 CNV Loss 21882294
nsv469936 CNV Loss 18288195
nsv522567 CNV Loss 19592680
nsv527329 CNV Loss 19592680
nsv7663 CNV Insertion 18451855

Variation tolerance for LMO1 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LMO1 Gene

Disorders for LMO1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LMO1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
lymphoblastic leukemia
  • acute lymphocytic leukemia
cd3epsilon deficiency
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
- elite association - COSMIC cancer census association via MalaCards
Search LMO1 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Genatlas disease for LMO1 Gene

acute lymphoblastic leukemia (T ALL),with translocation t(11;14)(p15;q11),and a LMO1/LDB1 interaction,likely involved in tumorigenesis

Relevant External Links for LMO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LMO1: view

Publications for LMO1 Gene

  1. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. (PMID: 1703797) McGuire E.A. … Korsmeyer S.J. (Blood 1991) 2 3 4 67
  2. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. (PMID: 17471240) Saeki N. … Sasaki H. (Oncogene 2007) 3 23
  3. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PMID: 11528126) Cichutek A. … Zabel B.U. (Cytogenet. Cell Genet. 2001) 3 23
  4. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). (PMID: 9872335) Valge-Archer V. … Rabbitts T.H. (Oncogene 1998) 3 23
  5. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. (PMID: 1507224) Foroni L. … Rabbitts T.H. (J. Mol. Biol. 1992) 3 23

Products for LMO1 Gene

Sources for LMO1 Gene