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LMO1 Gene

protein-coding   GIFtS: 59
GCID: GC11M008245

LIM Domain Only 1 (Rhombotin 1)


(Previous symbol: RBTN1)
  See LMO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Domain Only 1 (Rhombotin 1)1 2     TTG12 3
RBTN11 2 3 5     LIM Domain Only Protein 12 3
RHOM12 3 5     T-Cell Translocation Protein 12 3
Cysteine-Rich Protein TTG-12 3     rhombotin-12
LMO-12 3     T-Cell Translocation Gene 12

External Ids:    HGNC: 66411   Entrez Gene: 40042   Ensembl: ENSG000001664077   OMIM: 1869215   UniProtKB: P258003   

Export aliases for LMO1 gene to outside databases

Previous GC identifers: GC11M009030 GC11M008706 GC11M008204 GC11M008210 GC11M008202 GC11M007915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMO1 Gene:
This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding
domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription
by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been
associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this
locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1
gene. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2012)

GeneCards Summary for LMO1 Gene:
LMO1 (LIM domain only 1 (rhombotin 1)) is a protein-coding gene. Diseases associated with LMO1 include cd3epsilon deficiency, and acute t cell leukemia. An important paralog of this gene is LMO4.

UniProtKB/Swiss-Prot: RBTN1_HUMAN, P25800
Function: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by
binding to other transcription factors

Gene Wiki entry for LMO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMO1 gene promoter:
         Pbx1a   GATA-3   FOXD3   AP-4   POU3F2   c-Ets-1   AREB6   COMP1   HSF2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMO1 promoter sequence
   Search Chromatin IP Primers for LMO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

LMO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMO1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M008245:  view genomic region     (about GC identifiers)

Start:
8,245,851 bp from pter      End:
8,290,263 bp from pter
Size:
44,413 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBTN1_HUMAN, P25800 (See protein sequence)
Recommended Name: Rhombotin-1  
Size: 156 amino acids; 17828 Da
Sequence caution: Sequence=AAH39512.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: E9PSF5 Q4VBC5 Q8IXR0
Alternative splicing: 2 isoforms:  P25800-1   P25800-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LMO1: NX_P25800

Explore proteomics data for LMO1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LMO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257357.1  NP_002306.1  

    ENSEMBL proteins: 
     ENSP00000338207   ENSP00000404538   ENSP00000435456  

    LMO1 Human Recombinant Protein Products:

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    Novus Biologicals LMO1 Proteins
    Novus Biologicals LMO1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LMO1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for LMO1 

    LMO1 Antibody Products:

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    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for LMO1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P25800

    ProtoNet protein and cluster: P25800

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: RBTN1_HUMAN, P25800
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with LMO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBTN1_HUMAN, P25800
    Function: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by
    binding to other transcription factors

         Genatlas biochemistry entry for LMO1:
    LIM domain only 1,rhombotin 1,expressed in rhombomeres

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with LMO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LMO1:
     Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lmo1):
     mortality/aging  normal 

    Find genes that share phenotypes with LMO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lmo1tm1Thr for LMO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMO1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMO1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMO1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMO1

    miRNA
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    Block miRNA regulation of human, mouse, rat LMO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO1 (see all 12):
    hsa-miR-3163 hsa-miR-181c hsa-let-7a-2* hsa-miR-181a hsa-miR-181d hsa-miR-4261 hsa-miR-494 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLMO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMO1
    Predesigned siRNA for gene silencing in human, mouse, rat LMO1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for LMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMO1 (NM_002315)
    Sino Biological Human cDNA Clone for LMO1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LMO1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBTN1_HUMAN, P25800: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    Find genes that share ontologies with LMO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including LMO1: 
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMO1 (P258003 ENSP000003382074) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237713, ENSP000003686324I2D: score=3 STRING: ENSP00000368632
    LDB1Q86U703, ENSP000003924664I2D: score=3 STRING: ENSP00000392466
    TAL1P175423, ENSP000002943394I2D: score=3 STRING: ENSP00000294339
    TAL2Q165593, ENSP000003345474I2D: score=3 STRING: ENSP00000334547
    NHLH1Q025753, ENSP000003021894I2D: score=2 STRING: ENSP00000302189
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP--

    Find genes that share ontologies with LMO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMO1 (RBTN1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LMO1 gene (2 alternative transcripts): 
    NM_001270428.1  NM_002315.2  

    Unigene Cluster for LMO1:

    LIM domain only 1 (rhombotin 1)
    Hs.654426  [show with all ESTs]
    Unigene Representative Sequence: NR_073006
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335790(uc001mgg.1 uc009yfo.1) ENST00000428101(uc001mgh.1)
    ENST00000524379 ENST00000534484
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMO1 (see all 12):
    hsa-miR-3163 hsa-miR-181c hsa-let-7a-2* hsa-miR-181a hsa-miR-181d hsa-miR-4261 hsa-miR-494 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidLMO1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LMO1
    Predesigned siRNA for gene silencing in human, mouse, rat LMO1
    Clone
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    OriGene clones in human, mouse for LMO1 (see all 5)
    OriGene ORF clones in mouse, rat for LMO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMO1 (NM_002315)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMO1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMO1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LMO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMO1
      QuantiTect SYBR Green Assays in human, mouse, rat LMO1
      QuantiFast Probe-based Assays in human, mouse, rat LMO1

    Additional mRNA sequence: 

    BC039512.1 BC069673.1 BC069752.1 BC069793.1 BC096056.3 BC096057.3 BC096058.1 M26682.1 
    NR_073006.1 X64244.1 X64245.1 X64246.1 X64247.1 

    5 DOTS entries:

    DT.101961410  DT.100695631  DT.100021771  DT.120734475  DT.402183 

    Selected AceView cDNA sequences (see all 38):

    X64246 CK819565 X64247 BE251811 BM465945 BM129552 BU781888 BM510258 
    BQ270703 BC069752 X64245 BC069793 BM708021 BV191184 BX100436 BF515153 
    BC069673 X64244 AI939565 BU552557 BC039512 AJ574132 BM894527 NM_002315 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LMO1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:        -     -                 -                     
    SP2:                                -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for LMO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LMO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTTGTGTC
    LMO1 Expression
    About this image


    LMO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
             Floor plate-like cells
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
    LMO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654426

    UniProtKB/Swiss-Prot: RBTN1_HUMAN, P25800
    Tissue specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including
    thymus

        Pathway & Disease-focused RT2 Profiler PCR Array including LMO1: 
              Leukemia in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LMO1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmo11 , 5 LIM domain only 11, 5 93.16(n)1
    98.72(a)1
      7 (57.21 cM)5
    1095941  NM_057173.21  NP_476514.11 
     1091385725 
    chicken
    (Gallus gallus)
    Aves LOC1008587921 rhombotin-1-like 84.83(n)
    97.44(a)
      100858792  XM_004941393.1  XP_004941450.1 
    lizard
    (Anolis carolinensis)
    Reptilia LMO16
    LIM domain only 1 (rhombotin 1)
    94(a)
    1 ↔ 1
    GL343294.1(932669-974781)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.322632 Xenopus laevis transcribed sequence with strong similarity more 83.5(n)    BJ630232.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmo12 LIM domain only 1 84.06(n)   280646  AF398514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bx3 wing morphogenesis 79(a)   1 17C4   --
    rice
    (Oryza sativa)
    Liliopsida Os.90212 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 100(n)    AK120832.1 


    ENSEMBL Gene Tree for LMO1 (if available)
    TreeFam Gene Tree for LMO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LMO1 gene
    LMO42  LMO22  LMO32  
    Selected SIMAP similar genes for LMO1 using alignment to 4 protein entries:     RBTN1_HUMAN (see all proteins) (see all similar genes):
    LMO3    LHx4    LMO2    LMO4    LHX4    ISL2
    LHX1    LHX3    LMX1B    ISL1    LHX9    LHX8
    LHX2    LHX6    ABLIM1    LPXN    LIMS2    PXN

    Find genes that share paralogs with LMO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LMO1 (see all 1109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752233701,2
    --7939597(+) TTTTTA/TATTTT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs57895711,2
    C--7946202(+) TGAGCATGGCC  
      TGGA
    /-
    ATGGC
    3 -- int11Minor allele frequency- -:0.50NA 2
    rs347599171,2
    C--7946211(+) CCTGG-/AATG  
      GCCTGG
    GAGAA
    3 -- int10--------
    rs1893271831,2
    --8169935(+) AAAGGA/GAACAG 3 -- ds50010--------
    rs110418171,2
    F,H--8170130(+) GTCTGG/CGGTCT 3 -- ds50014Minor allele frequency- C:0.01NS EA 406
    rs1922415241,2
    C--8170308(+) CTAAAG/TCCAGC 3 -- ds50010--------
    rs1844443771,2
    --8170325(+) CTCCCC/TTGCCC 3 -- ds50010--------
    rs1888019951,2
    --8170405(+) CCCAGG/TTCTGT 3 -- ds50010--------
    rs1168754511,2
    F--8170468(+) ATCCAC/TGCCAG 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.01NA 120
    rs1812345501,2
    --8170478(+) GTAATA/GAAATC 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for LMO1 (8245851 - 8290263 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LMO1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7663CNV Insertion18451855
    nsv522567CNV Loss19592680
    nsv469936CNV Loss18288195
    nsv527329CNV Loss19592680
    nsv896982CNV Loss21882294
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LMO1
    DNA2.0 Custom Variant and Variant Library Synthesis for LMO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186921    OMIM disorders: --

    UniProtKB/Swiss-Prot: RBTN1_HUMAN, P25800
  • Note=A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic
    leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD

  • 4 diseases for LMO1:    
    About MalaCards
    cd3epsilon deficiency    acute t cell leukemia    exencephaly    t-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for LMO1:
    Leukemia

    Find genes that share disorders with LMO1           About GenesLikeMe

    5 Novoseek inferred disease relationships for LMO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 85.3 8 14582078 (1), 16778171 (1), 11243382 (1), 10373552 (1) (see all 7)
    exencephaly 71.6 1 14966285 (1)
    leukemia t-cell 63.7 3 14966285 (1), 16778171 (1), 15691703 (1)
    leukemia 50.5 3 20516195 (1), 9872335 (1), 14975618 (1)
    acute leukemia 32.9 5 9872335 (3), 1507224 (1)

    Genatlas disease: LMO1
    acute lymphoblastic leukemia (T ALL),with translocation t(11;14)(p15;q11),and a LMO1/LDB1 interaction,likely
    involved in tumorigenesis

    Genetic Association Database (GAD): LMO1
    Human Genome Epidemiology (HuGE) Navigator: LMO1 (3 documents)
    Tumor Gene Database (TGDB): LMO1

    Export disorders for LMO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMO1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with LMO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. (PubMed id 1703797)1, 2, 3 McGuire E.A.... Korsmeyer S.J. (Blood 1991)
    2. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). (PubMed id 11528126)1, 2, 9 Cichutek A.... Zabel B.U. (Cytogenet. Cell Genet. 2001)
    3. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. (PubMed id 21124317)1, 4 Wang K....Maris J.M. (Nature 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. (PubMed id 2034676)1, 3 Boehm T....Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    7. Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. (PubMed id 2052354)1, 2 Boehm T....Rabbitts T.H. (Oncogene 1991)
    8. An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs. (PubMed id 2311586)1, 2 Boehm T....Rabbitts T.H. (EMBO J. 1990)
    9. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. (PubMed id 2501659)1, 2 McGuire E.A.... Korsmeyer S.J. (Mol. Cell. Biol. 1989)
    10. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). (PubMed id 9872335)1, 9 Valge-Archer V....Rabbitts T.H. (Oncogene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4004 HGNC: 6641 AceView: LMO1 Ensembl:ENSG00000166407 euGenes: HUgn4004
    ECgene: LMO1 H-InvDB: LMO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LMO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LMO1 gene:
    Search GeneIP for patents involving LMO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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