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Aliases for LMNTD2 Gene

Aliases for LMNTD2 Gene

  • Lamin Tail Domain Containing 2 2 3 5
  • C11orf35 3 4
  • Lamin Tail Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 35 2

External Ids for LMNTD2 Gene

Previous HGNC Symbols for LMNTD2 Gene

  • C11orf35

Summaries for LMNTD2 Gene

GeneCards Summary for LMNTD2 Gene

LMNTD2 (Lamin Tail Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNTD2 Gene

Genomics for LMNTD2 Gene

Regulatory Elements for LMNTD2 Gene

Enhancers for LMNTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000514 0.2 ENCODE 12.8 +45.6 45557 1.8 CEBPB RNH1 HRAS RASSF7 ENSG00000254815 LMNTD2 PTDSS2 SLC25A22 CEND1 PIDD1 RPLP2
GH11F000559 0.2 ENCODE 7.5 -2.1 -2136 7.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 FOS PAF1 HRAS TMEM80 ENSG00000255237 LMNTD2 PKP3 PHRF1 RNH1 PTDSS2 GC11M000563
GH11F000534 0.5 ENCODE 7 +24.5 24491 4.3 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A ZNF143 ZNF207 FOS LRRC56 HRAS RNH1 TMEM80 DRD4 ENSG00000255142 ENSG00000255158 ENSG00000255237 LMNTD2 LOC101059906
GH11F000636 0.8 Ensembl ENCODE 5.5 -78.3 -78340 5.5 CTCF KLF1 ZNF837 TEAD4 ZIC2 HIC1 GLIS2 POLR2A ZNF600 KLF8 TMEM80 PTDSS2 CDHR5 HRAS LMNTD2 OR4F2P ENSG00000254815 DRD4 GC11P000641
GH11F001050 1.1 Ensembl ENCODE 4.3 -490.4 -490421 0.8 ELF3 ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF48 ZNF335 ZNF143 ZNF207 MUC2 AP2A2 PIDD1 RPLP2 SLC25A22 CEND1 LMNTD2 GC11P001047 PIR44225
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LMNTD2 on UCSC Golden Path with GeneCards custom track

Promoters for LMNTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001601182 -320 1801 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 FOS

Genomic Location for LMNTD2 Gene

Chromosome:
11
Start:
554,850 bp from pter
End:
560,780 bp from pter
Size:
5,931 bases
Orientation:
Minus strand

Genomic View for LMNTD2 Gene

Genes around LMNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD2 Gene

Proteins for LMNTD2 Gene

  • Protein details for LMNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXW0-LMTD2_HUMAN
    Recommended name:
    Lamin tail domain-containing protein 2
    Protein Accession:
    Q8IXW0

    Protein attributes for LMNTD2 Gene

    Size:
    634 amino acids
    Molecular mass:
    70379 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LMNTD2 Gene

Post-translational modifications for LMNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD2 Gene

Domains & Families for LMNTD2 Gene

Protein Domains for LMNTD2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXW0

UniProtKB/Swiss-Prot:

LMTD2_HUMAN :
  • Contains 1 LTD domain.
Domain:
  • Contains 1 LTD domain.
genes like me logo Genes that share domains with LMNTD2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LMNTD2 Gene

Function for LMNTD2 Gene

Phenotypes for LMNTD2 Gene

GenomeRNAi human phenotypes for LMNTD2:
genes like me logo Genes that share phenotypes with LMNTD2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD2 Gene

Localization for LMNTD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LMNTD2 Gene

Pathways & Interactions for LMNTD2 Gene

SuperPathways for LMNTD2 Gene

No Data Available

Interacting Proteins for LMNTD2 Gene

Gene Ontology (GO) - Biological Process for LMNTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with LMNTD2: view

No data available for Pathways by source and SIGNOR curated interactions for LMNTD2 Gene

Transcripts for LMNTD2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD2 Gene

No ASD Table

Relevant External Links for LMNTD2 Gene

GeneLoc Exon Structure for
LMNTD2
ECgene alternative splicing isoforms for
LMNTD2

Expression for LMNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMNTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMNTD2 Gene

This gene is overexpressed in Fetal heart (58.2) and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMNTD2 Gene



Protein tissue co-expression partners for LMNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMNTD2 Gene:

LMNTD2
genes like me logo Genes that share expression patterns with LMNTD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LMNTD2 Gene

Orthologs for LMNTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf35 34
  • 98.62 (n)
C11orf35 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf35 34
  • 71.33 (n)
C11orf35 35
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1600016N20Rik 34 35
  • 67.53 (n)
Lmntd2 16
rat
(Rattus norvegicus)
Mammalia RGD1307439 34
  • 65.46 (n)
cow
(Bos Taurus)
Mammalia C11orf35 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf35 35
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf35 35
  • 41 (a)
OneToOne
Species where no ortholog for LMNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LMNTD2 Gene

ENSEMBL:
Gene Tree for LMNTD2 (if available)
TreeFam:
Gene Tree for LMNTD2 (if available)

Paralogs for LMNTD2 Gene

No data available for Paralogs for LMNTD2 Gene

Variants for LMNTD2 Gene

Sequence variations from dbSNP and Humsavar for LMNTD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111565913 -- 558,173(+) GCTCG(A/C)TCCTT upstream-variant-2KB, reference, missense
rs111784302 -- 559,579(+) GGCCC(C/T)AGCAT intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs111862990 -- 562,707(+) CGGCA(C/G)AGTGC upstream-variant-2KB, reference, missense
rs112162682 -- 559,299(+) CCTCT(-/TT)CTCTC intron-variant, upstream-variant-2KB
rs11246183 -- 554,389(+) GCCTG(A/G)CCCTG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LMNTD2 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
esv3625070 CNV loss 21293372
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for LMNTD2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMNTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD2 Gene

Disorders for LMNTD2 Gene

Relevant External Links for LMNTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMNTD2

No disorders were found for LMNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMNTD2 Gene

Publications for LMNTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for LMNTD2 Gene

Sources for LMNTD2 Gene

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