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Aliases for LMNTD2 Gene

Aliases for LMNTD2 Gene

  • Lamin Tail Domain Containing 2 2 3 5
  • C11orf35 3 4
  • Lamin Tail Domain-Containing Protein 2 3
  • Chromosome 11 Open Reading Frame 35 2

External Ids for LMNTD2 Gene

Previous HGNC Symbols for LMNTD2 Gene

  • C11orf35

Summaries for LMNTD2 Gene

GeneCards Summary for LMNTD2 Gene

LMNTD2 (Lamin Tail Domain Containing 2) is a Protein Coding gene.

Additional gene information for LMNTD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNTD2 Gene

Genomics for LMNTD2 Gene

Regulatory Elements for LMNTD2 Gene

Enhancers for LMNTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000559 1.3 ENCODE dbSUPER 7.4 -2.1 -2136 7 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 FOS PAF1 PHRF1 HRAS TMEM80 LMNTD2 PKP3 RNH1 PTDSS2 GC11M000563
GH11H000534 1.3 ENCODE dbSUPER 7 +24.5 24491 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZBTB7B ZNF143 ZNF207 FOS TMEM80 LRRC56 HRAS RNH1 PIDD1 DRD4 PHRF1 GATD1 ENSG00000255142 ENSG00000255158
GH11H000514 0.7 ENCODE dbSUPER 12.8 +45.6 45557 1 CEBPB CEBPG RNH1 HRAS LOC692247 RASSF7 LMNTD2 PTDSS2 CEND1 SLC25A22 PIDD1 RPLP2
GH11H000636 0.9 Ensembl ENCODE 5.5 -78.3 -78340 5 KLF1 ZIC2 HIC1 ZFP69B GLIS2 POLR2A ZNF341 GLIS1 FOXP2 ZBTB33 TMEM80 PTDSS2 CDHR5 HRAS LMNTD2 OR4F2P LOC692247 GC11P000641 DRD4
GH11H001050 0.8 dbSUPER 4.3 -490.1 -490075 0 CTCF KLF1 KLF17 MAX SIN3A PAX8 ZNF2 RAD21 ZFHX2 GATAD1 AP2A2 PIDD1 RPLP2 SLC25A22 CEND1 LOC101927503 LMNTD2 GC11P001047 PIR44225
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMNTD2 on UCSC Golden Path with GeneCards custom track

Promoters for LMNTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035651 -420 1601 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 GLIS2 ZNF143 ATF7

Genomic Location for LMNTD2 Gene

Chromosome:
11
Start:
554,850 bp from pter
End:
560,780 bp from pter
Size:
5,931 bases
Orientation:
Minus strand

Genomic View for LMNTD2 Gene

Genes around LMNTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD2 Gene

Proteins for LMNTD2 Gene

  • Protein details for LMNTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXW0-LMTD2_HUMAN
    Recommended name:
    Lamin tail domain-containing protein 2
    Protein Accession:
    Q8IXW0

    Protein attributes for LMNTD2 Gene

    Size:
    634 amino acids
    Molecular mass:
    70379 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LMNTD2 Gene

Post-translational modifications for LMNTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD2 Gene

Domains & Families for LMNTD2 Gene

Gene Families for LMNTD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LMNTD2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LMNTD2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for LMNTD2 Gene

Function for LMNTD2 Gene

Phenotypes for LMNTD2 Gene

GenomeRNAi human phenotypes for LMNTD2:
genes like me logo Genes that share phenotypes with LMNTD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LMNTD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD2 Gene

Localization for LMNTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMNTD2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LMNTD2 Gene

Pathways & Interactions for LMNTD2 Gene

SuperPathways for LMNTD2 Gene

No Data Available

Interacting Proteins for LMNTD2 Gene

Gene Ontology (GO) - Biological Process for LMNTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with LMNTD2: view

No data available for Pathways by source and SIGNOR curated interactions for LMNTD2 Gene

Drugs & Compounds for LMNTD2 Gene

No Compound Related Data Available

Transcripts for LMNTD2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LMNTD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD2 Gene

No ASD Table

Relevant External Links for LMNTD2 Gene

GeneLoc Exon Structure for
LMNTD2
ECgene alternative splicing isoforms for
LMNTD2

Expression for LMNTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMNTD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMNTD2 Gene

This gene is overexpressed in Fetal heart (58.2) and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMNTD2 Gene



Protein tissue co-expression partners for LMNTD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMNTD2 Gene:

LMNTD2

Evidence on tissue expression from TISSUES for LMNTD2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LMNTD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMNTD2 Gene

Orthologs for LMNTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf35 33
  • 98.62 (n)
C11orf35 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf35 33
  • 71.33 (n)
C11orf35 34
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1600016N20Rik 33 34
  • 67.53 (n)
Lmntd2 16
rat
(Rattus norvegicus)
Mammalia RGD1307439 33
  • 65.46 (n)
cow
(Bos Taurus)
Mammalia C11orf35 34
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf35 34
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf35 34
  • 41 (a)
OneToOne
Species where no ortholog for LMNTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LMNTD2 Gene

ENSEMBL:
Gene Tree for LMNTD2 (if available)
TreeFam:
Gene Tree for LMNTD2 (if available)

Paralogs for LMNTD2 Gene

No data available for Paralogs for LMNTD2 Gene

Variants for LMNTD2 Gene

Sequence variations from dbSNP and Humsavar for LMNTD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000454829 -- 554,607(+) GAATT(A/G)GGCAT downstream-variant-500B, utr-variant-3-prime
rs1000856296 -- 562,111(+) AGCGG(C/T)TTCGG upstream-variant-2KB, reference, missense
rs1001272694 -- 556,153(+) GCCGG(A/G)CCGGG intron-variant
rs1001576130 -- 559,692(+) ACAGT(A/G)ACAAG intron-variant, upstream-variant-2KB
rs1001759149 -- 561,199(+) CGCCA(A/G/T)GCTGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LMNTD2 Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
esv3625070 CNV loss 21293372
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv528415 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for LMNTD2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMNTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMNTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD2 Gene

Disorders for LMNTD2 Gene

Relevant External Links for LMNTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMNTD2

No disorders were found for LMNTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMNTD2 Gene

Publications for LMNTD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60

Products for LMNTD2 Gene

Sources for LMNTD2 Gene

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