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Aliases for LMNTD1 Gene

Aliases for LMNTD1 Gene

  • Lamin Tail Domain Containing 1 2 3 5
  • Intermediate Filament Tail Domain-Containing Protein 1 3 4
  • Intermediate Filament Tail Domain Containing 1 2 3
  • IFLTD1 3 4
  • Lamin Tail Domain-Containing Protein 1 3
  • LMNARS1 3
  • PAS1C1 3

External Ids for LMNTD1 Gene

Previous HGNC Symbols for LMNTD1 Gene

  • IFLTD1

Previous GeneCards Identifiers for LMNTD1 Gene

  • GC12M025410
  • GC12M025412
  • GC12M025414
  • GC12M025416
  • GC12M025418

Summaries for LMNTD1 Gene

GeneCards Summary for LMNTD1 Gene

LMNTD1 (Lamin Tail Domain Containing 1) is a Protein Coding gene. Diseases associated with LMNTD1 include Respiratory System Benign Neoplasm. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is LMNB2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNTD1 Gene

Genomics for LMNTD1 Gene

Regulatory Elements for LMNTD1 Gene

Enhancers for LMNTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G025614 1.2 Ensembl ENCODE 10.3 +33.4 33409 1.3 ATF1 GLI4 ELK1 FOS SP3 CAVIN1 TSHZ1 ZNF518A MAFF SMARCA4 LMNTD1 GC12P025604
GH12G025648 1.1 Ensembl ENCODE 0.7 -0.3 -271 1.6 MXI1 TAF1 MAX BCL11B ZIC2 RAD21 RFX5 GLIS2 PATZ1 SCRT2 LMNTD1 PIR52916
GH12G025655 0.6 ENCODE 0.4 -7.3 -7329 1.3 ZNF217 CTBP1 PKNOX1 ZNF146 KLF9 ZNF580 KDM1A DPF2 LMNTD1 PIR52916
GH12G025670 0.5 ENCODE 0.3 -22.3 -22308 0.2 JUND FOS PRDM4 RASSF8 RASSF8-AS1 PIR52916 LMNTD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMNTD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMNTD1 Gene

Chromosome:
12
Start:
25,409,307 bp from pter
End:
25,648,594 bp from pter
Size:
239,288 bases
Orientation:
Minus strand

Genomic View for LMNTD1 Gene

Genes around LMNTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD1 Gene

Proteins for LMNTD1 Gene

  • Protein details for LMNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Z9-LMTD1_HUMAN
    Recommended name:
    Lamin tail domain-containing protein 1
    Protein Accession:
    Q8N9Z9
    Secondary Accessions:
    • B4DL27
    • B4DY70
    • Q8IY38

    Protein attributes for LMNTD1 Gene

    Size:
    388 amino acids
    Molecular mass:
    43408 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMNTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMNTD1 Gene

Post-translational modifications for LMNTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD1 Gene

Domains & Families for LMNTD1 Gene

Protein Domains for LMNTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMNTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9Z9

UniProtKB/Swiss-Prot:

LMTD1_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with LMNTD1: view

No data available for Gene Families for LMNTD1 Gene

Function for LMNTD1 Gene

Gene Ontology (GO) - Molecular Function for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with LMNTD1: view
genes like me logo Genes that share phenotypes with LMNTD1: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD1 Gene

Localization for LMNTD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMNTD1 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 1

Gene Ontology (GO) - Cellular Components for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with LMNTD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LMNTD1 Gene

Pathways & Interactions for LMNTD1 Gene

SuperPathways for LMNTD1 Gene

No Data Available

Interacting Proteins for LMNTD1 Gene

Gene Ontology (GO) - Biological Process for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with LMNTD1: view

No data available for Pathways by source and SIGNOR curated interactions for LMNTD1 Gene

Drugs & Compounds for LMNTD1 Gene

No Compound Related Data Available

Transcripts for LMNTD1 Gene

mRNA/cDNA for LMNTD1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: -

Relevant External Links for LMNTD1 Gene

GeneLoc Exon Structure for
LMNTD1
ECgene alternative splicing isoforms for
LMNTD1

Expression for LMNTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMNTD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LMNTD1 Gene:

LMNTD1

Evidence on tissue expression from TISSUES for LMNTD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LMNTD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMNTD1 Gene

Orthologs for LMNTD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFLTD1 35 34
  • 98.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IFLTD1 35 34
  • 77.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IFLTD1 35 34
  • 74.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifltd1 34
  • 67.03 (n)
mouse
(Mus musculus)
Mammalia Ifltd1 35 34
  • 66.67 (n)
OneToOne
Lmntd1 16
oppossum
(Monodelphis domestica)
Mammalia IFLTD1 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFLTD1 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
OneToOne
Species where no ortholog for LMNTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LMNTD1 Gene

ENSEMBL:
Gene Tree for LMNTD1 (if available)
TreeFam:
Gene Tree for LMNTD1 (if available)

Paralogs for LMNTD1 Gene

Paralogs for LMNTD1 Gene

genes like me logo Genes that share paralogs with LMNTD1: view

Variants for LMNTD1 Gene

Sequence variations from dbSNP and Humsavar for LMNTD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000005853 -- 25,555,812(+) CTAAG(C/T)TCTCC intron-variant
rs1000010909 -- 25,601,573(+) TGTAC(A/C)CCACA intron-variant
rs1000023981 -- 25,523,836(+) AAAAA(A/G/T)GCTTG intron-variant
rs1000035930 -- 25,570,918(+) TTCTG(C/T)TGTTA intron-variant
rs1000039449 -- 25,561,287(+) TGCTA(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMNTD1 Gene

Variant ID Type Subtype PubMed ID
dgv262e214 CNV loss 21293372
esv1242262 CNV deletion 17803354
esv21824 CNV loss 19812545
esv2488733 CNV deletion 19546169
esv2665786 CNV deletion 23128226
esv2759885 CNV loss 17122850
esv3303102 CNV tandem duplication 20981092
esv3304453 CNV mobile element insertion 20981092
esv3306210 CNV mobile element insertion 20981092
esv3309343 CNV mobile element insertion 20981092
esv3339773 CNV insertion 20981092
esv3372528 CNV insertion 20981092
esv3407156 CNV insertion 20981092
esv3441415 CNV insertion 20981092
esv3548905 CNV deletion 23714750
esv3628896 CNV loss 21293372
esv3628897 CNV gain 21293372
esv3628898 CNV loss 21293372
esv3628902 CNV gain 21293372
esv5503 OTHER inversion 19470904
nsv1110892 OTHER inversion 24896259
nsv1143560 CNV deletion 24896259
nsv1159990 CNV deletion 26073780
nsv437731 CNV loss 16327808
nsv509460 CNV insertion 20534489
nsv519712 CNV loss 19592680
nsv520540 CNV loss 19592680
nsv832354 CNV gain 17160897
nsv951342 CNV deletion 24416366

Variation tolerance for LMNTD1 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMNTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMNTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMNTD1 Gene

Disorders for LMNTD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LMNTD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LMNTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMNTD1
genes like me logo Genes that share disorders with LMNTD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMNTD1 Gene

Publications for LMNTD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for LMNTD1 Gene

Sources for LMNTD1 Gene

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