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Aliases for LMNTD1 Gene

Aliases for LMNTD1 Gene

  • Lamin Tail Domain Containing 1 2 3 5
  • Intermediate Filament Tail Domain-Containing Protein 1 3 4
  • Intermediate Filament Tail Domain Containing 1 2 3
  • IFLTD1 3 4
  • PAS1C1 3

External Ids for LMNTD1 Gene

Previous HGNC Symbols for LMNTD1 Gene

  • IFLTD1

Previous GeneCards Identifiers for LMNTD1 Gene

  • GC12M025410
  • GC12M025412

Summaries for LMNTD1 Gene

GeneCards Summary for LMNTD1 Gene

LMNTD1 (Lamin Tail Domain Containing 1) is a Protein Coding gene. Diseases associated with LMNTD1 include respiratory system benign neoplasm. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is LMNB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMNTD1 Gene

Genomics for LMNTD1 Gene

Regulatory Elements for LMNTD1 Gene

Enhancers for LMNTD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMNTD1 on UCSC Golden Path with GeneCards custom track

Promoters for LMNTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LMNTD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMNTD1 Gene

Chromosome:
12
Start:
25,409,307 bp from pter
End:
25,648,594 bp from pter
Size:
239,288 bases
Orientation:
Minus strand

Genomic View for LMNTD1 Gene

Genes around LMNTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMNTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMNTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMNTD1 Gene

Proteins for LMNTD1 Gene

  • Protein details for LMNTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Z9-LMTD1_HUMAN
    Recommended name:
    Lamin tail domain-containing protein 1
    Protein Accession:
    Q8N9Z9
    Secondary Accessions:
    • B4DL27
    • B4DY70
    • Q8IY38

    Protein attributes for LMNTD1 Gene

    Size:
    388 amino acids
    Molecular mass:
    43408 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMNTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMNTD1 Gene

Proteomics data for LMNTD1 Gene at MOPED

Post-translational modifications for LMNTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMNTD1 Gene

Domains & Families for LMNTD1 Gene

Protein Domains for LMNTD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMNTD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9Z9

UniProtKB/Swiss-Prot:

LMTD1_HUMAN :
  • Contains 1 LTD domain.
  • Belongs to the intermediate filament family.
Domain:
  • Contains 1 LTD domain.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with LMNTD1: view

No data available for Gene Families for LMNTD1 Gene

Function for LMNTD1 Gene

genes like me logo Genes that share phenotypes with LMNTD1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMNTD1 Gene

Localization for LMNTD1 Gene

Gene Ontology (GO) - Cellular Components for LMNTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LMNTD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for LMNTD1 Gene

Pathways & Interactions for LMNTD1 Gene

SuperPathways for LMNTD1 Gene

No Data Available

Interacting Proteins for LMNTD1 Gene

Gene Ontology (GO) - Biological Process for LMNTD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LMNTD1 Gene

Drugs & Compounds for LMNTD1 Gene

No Compound Related Data Available

Transcripts for LMNTD1 Gene

mRNA/cDNA for LMNTD1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LMNTD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: -

Relevant External Links for LMNTD1 Gene

GeneLoc Exon Structure for
LMNTD1
ECgene alternative splicing isoforms for
LMNTD1

Expression for LMNTD1 Gene

mRNA expression in normal human tissues for LMNTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMNTD1 Gene



genes like me logo Genes that share expression patterns with LMNTD1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LMNTD1 Gene

Orthologs for LMNTD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LMNTD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFLTD1 35
  • 74.86 (n)
  • 60.55 (a)
IFLTD1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFLTD1 35
  • 77.69 (n)
  • 67.17 (a)
IFLTD1 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifltd1 35
  • 66.67 (n)
  • 55.61 (a)
Lmntd1 16
Ifltd1 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFLTD1 35
  • 98.61 (n)
  • 97.56 (a)
IFLTD1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifltd1 35
  • 67.03 (n)
  • 56.33 (a)
oppossum
(Monodelphis domestica)
Mammalia IFLTD1 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFLTD1 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToOne
Species with no ortholog for LMNTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LMNTD1 Gene

ENSEMBL:
Gene Tree for LMNTD1 (if available)
TreeFam:
Gene Tree for LMNTD1 (if available)

Paralogs for LMNTD1 Gene

Paralogs for LMNTD1 Gene

genes like me logo Genes that share paralogs with LMNTD1: view

Variants for LMNTD1 Gene

Sequence variations from dbSNP and Humsavar for LMNTD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35450203 - 25,520,021(+) GTCAG(C/T)ATCTA nc-transcript-variant, reference, missense
rs34326830 - 25,520,011(+) TAAAT(C/T)CAACG nc-transcript-variant, reference, missense
rs34732786 - 25,519,946(+) AGCTG(C/T)AGATG downstream-variant-500B, reference, missense
rs34074522 - 25,519,943(+) TGTAG(C/T)TGTAG downstream-variant-500B, reference, missense
rs1479500 - 25,518,825(-) CCAGG(A/T)CTCGG reference, missense

Variation tolerance for LMNTD1 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMNTD1 Gene

HapMap Linkage Disequilibrium report
LMNTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LMNTD1 Gene

Disorders for LMNTD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LMNTD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LMNTD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMNTD1
genes like me logo Genes that share disorders with LMNTD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMNTD1 Gene

Publications for LMNTD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LMNTD1 Gene

Sources for LMNTD1 Gene

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