Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LMNB2 Gene

protein-coding   GIFtS: 64
GCID: GC19M002428

Lamin B2


(Previous symbol: LMN2)
  See LMNB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lamin B21 2
LMN21 2 3 5
LAMB22
lamin-B22

External Ids:    HGNC: 66381   Entrez Gene: 848232   Ensembl: ENSG000001766197   OMIM: 1503415   UniProtKB: Q032523   

Export aliases for LMNB2 gene to outside databases

Previous GC identifers: GC19U990060 GC19M002498 GC19M002368 GC19M002379 GC19M002200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LMNB2 Gene:
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins
located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly
conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are
phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene
expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired
partial lipodystrophy. (provided by RefSeq, May 2012)

GeneCards Summary for LMNB2 Gene:
LMNB2 (lamin B2) is a protein-coding gene. Diseases associated with LMNB2 include barraquer-simons syndrome, and reynolds syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is LMNB1.

UniProtKB/Swiss-Prot: LMNB2_HUMAN, Q03252
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
chromatin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMNB2 gene promoter:
         c-Fos   c-Rel   AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMNB2 promoter sequence
   Search Chromatin IP Primers for LMNB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMNB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

LMNB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNB2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002428:  view genomic region     (about GC identifiers)

Start:
2,427,636 bp from pter      End:
2,456,994 bp from pter
Size:
29,359 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LMNB2_HUMAN, Q03252 (See protein sequence)
Recommended Name: Lamin-B2 precursor  
Size: 600 amino acids; 67689 Da
Subunit: Interacts with TMEM43 (By similarity)
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
1 PDB 3D structure from and Proteopedia for LMNB2:
2LLL (3D)    
Secondary accessions: O75292 Q14734 Q96DF6

Explore the universe of human proteins at neXtProt for LMNB2: NX_Q03252

Explore proteomics data for LMNB2 at MOPED

Post-translational modifications: 

  • B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased
    phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin
    associations1
  • Ubiquitination2 at Lys57, Lys61, Lys103, Lys130, Lys150, Lys255, Lys265, Lys278, Lys306, Lys373,
                                 Lys383, Lys496, Lys500
  • Modification sites at PhosphoSitePlus

  • See LMNB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116126.3  
    ENSEMBL proteins: 
     ENSP00000327054   ENSP00000462730  

    LMNB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LMNB2
    OriGene Protein Over-expression Lysate for LMNB2
    OriGene MassSpec for LMNB2
    OriGene Custom Protein Services for LMNB2
    GenScript Custom Purified and Recombinant Proteins Services for LMNB2
    Novus Biologicals LMNB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LMNB2

     
    Search eBioscience for Proteins for LMNB2 

    LMNB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNB2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNB2  (Lamin B2)
    OriGene Antibodies for LMNB2
    OriGene Custom Antibody Services for LMNB2
    Novus Biologicals LMNB2 Antibodies
    Abcam antibodies for LMNB2 (Q03252, P20700)
    Cloud-Clone Corp. Antibodies for LMNB2
    ThermoFisher Antibody for LMNB2
    LSBio Antibodies in human, mouse, rat for LMNB2

    LMNB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMNB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMNB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMNB2
    Cloud-Clone Corp. CLIAs for LMNB2
    Search eBioscience for ELISAs for LMNB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFF5: Intermediate filaments type V, lamins

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry Q03252

    ProtoNet protein and cluster: Q03252

    2 Blocks protein domains:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNB2_HUMAN, Q03252
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with LMNB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMNB2_HUMAN, Q03252
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
    nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
    chromatin

         Genatlas biochemistry entry for LMNB2:
    lamin,type B2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with LMNB2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LMNB2:
     Increased S DNA content, incre 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lmnb2):
     cellular  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 
     reproductive system  respiratory system 

    Find genes that share phenotypes with LMNB2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lmnb2tm1Yxz for LMNB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMNB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMNB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMNB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMNB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMNB2:
    hsa-mir-122-5p (MIRT023401), hsa-mir-215-5p (MIRT024348), hsa-mir-30a-5p (MIRT005131), hsa-mir-18a-3p (MIRT040957), hsa-mir-193b-3p (MIRT041386), hsa-mir-27a-3p (MIRT028693), hsa-mir-877-3p (MIRT037165), hsa-mir-18a-5p (MIRT031312), hsa-mir-423-5p (MIRT038062), hsa-mir-92a-3p (MIRT049504), hsa-mir-935 (MIRT036694), hsa-mir-192-5p (MIRT004852)

    Block miRNA regulation of human, mouse, rat LMNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNB2 (see all 35):
    hsa-miR-194* hsa-miR-330-5p hsa-let-7a-2* hsa-miR-449a hsa-miR-3613-3p hsa-miR-326 hsa-miR-186 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidLMNB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMNB2
    Predesigned siRNA for gene silencing in human, mouse, rat LMNB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMNB2

    Clone
    Products:
         
    OriGene clones in human, mouse for LMNB2 (see all 8)
    OriGene ORF clones in mouse, rat for LMNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMNB2 (NM_032737)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNB2
    Addgene plasmids for LMNB2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMNB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMNB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LMNB2_HUMAN, Q03252: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope ----
    GO:0005637nuclear inner membrane IEA--
    GO:0005638lamin filament ----
    GO:0005652nuclear lamina ----
    GO:0005882intermediate filament IEA--

    Find genes that share ontologies with LMNB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LMNB2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    2Granzyme Pathway
    Granzyme Pathway
    Granzyme-B Pathway0.00
    3DREAM Repression and Dynorphin Expression
    Caspase Cascade0.36
    4TWEAK Pathway
    Fas Signaling0.35
    5Gastric cancer network 2
    Gastric cancer network 2


    Find genes that share SuperPaths with LMNB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LMNB2
        Caspase Cascade
    Granzyme-B Pathway
    Granzyme Pathway
    Fas Signaling

    2 Cell Signaling Technology (CST) Pathways for LMNB2
        Apoptosis and Autophagy
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNB2
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    3 BioSystems Pathways for LMNB2
        FAS pathway and Stress induction of HSP regulation
    Gastric cancer network 2
    Caspase cascade in apoptosis


        Pathway & Disease-focused RT2 Profiler PCR Array including LMNB2: 
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMNB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMNB2 (Q032522, 3 ENSP000003270544) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823, ENSP000002158324I2D: score=4 STRING: ENSP00000215832
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    LMNAP025453, ENSP000003572834I2D: score=1 STRING: ENSP00000357283
    TMPOP421663, ENSP000002667324I2D: score=1 STRING: ENSP00000266732
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with LMNB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMNB2

    2 Novoseek inferred chemical compound relationships for LMNB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dihydrofolate 32.3 1 10577395 (1)
    serine 3 1 15546914 (1)



    Find genes that share compounds with LMNB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LMNB2 gene: 
    NM_032737.3  

    Unigene Cluster for LMNB2:

    Lamin B2
    Hs.538286  [show with all ESTs]
    Unigene Representative Sequence: NM_032737
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532465 ENST00000325327(uc002lvy.3) ENST00000475819 ENST00000490554
    ENST00000527409 ENST00000534495 ENST00000582871
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMNB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNB2 (see all 35):
    hsa-miR-194* hsa-miR-330-5p hsa-let-7a-2* hsa-miR-449a hsa-miR-3613-3p hsa-miR-326 hsa-miR-186 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidLMNB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LMNB2
    Predesigned siRNA for gene silencing in human, mouse, rat LMNB2
    Clone
    Products:
         
    OriGene clones in human, mouse for LMNB2 (see all 8)
    OriGene ORF clones in mouse, rat for LMNB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMNB2 (NM_032737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNB2
    Addgene plasmids for LMNB2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNB2
      QuantiTect SYBR Green Assays in human, mouse, rat LMNB2
      QuantiFast Probe-based Assays in human, mouse, rat LMNB2

    Additional mRNA sequence: 

    AK129641.1 BC006513.2 BC006551.2 BC009267.2 BT007441.1 

    22 DOTS entries:

    DT.100038869  DT.92455928  DT.121414790  DT.97857995  DT.454046  DT.100789803  DT.121414403  DT.95263113 
    DT.95263123  DT.100789807  DT.121414616  DT.95263124  DT.100814691  DT.40116196  DT.95263125  DT.100789815 
    DT.121414673  DT.95324050  DT.121414607  DT.95114992  DT.100814697  DT.445441 

    Selected AceView cDNA sequences (see all 529):

    BG176606 BU521577 CD515448 BM687311 AU125319 CR606147 CR608783 AW246588 
    BM795037 BQ575598 BM854155 BM743145 BE797199 BM773201 CD365365 BP342038 
    BQ058792 BQ216720 BM819839 AU154627 F29206 AW248577 BE221998 BU553247 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LMNB2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                                                                     
    SP2:                                -                                                                     
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for LMNB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LMNB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAATGTGT
    LMNB2 Expression
    About this image


    LMNB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    LMNB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMNB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.538286
        Pathway & Disease-focused RT2 Profiler PCR Array including LMNB2: 
              TNF Ligands & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMNB2
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNB2
    QuantiTect SYBR Green Assays in human, mouse, rat LMNB2
    QuantiFast Probe-based Assays in human, mouse, rat LMNB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LMNB2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmnb21 , 5 lamin B21, 5 82.29(n)1
    84.43(a)1
      10 (39.72 cM)5
    169071  NM_010722.51  NP_034852.21 
     809012035 
    chicken
    (Gallus gallus)
    Aves LMNB21 lamin B2 74.3(n)
    80.3(a)
      396222  NM_205285.1  NP_990616.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    58(a)
    many ↔ many
    2(29307462-29336927)
    African clawed frog
    (Xenopus laevis)
    Amphibia X54099.12   -- 73.88(n)    X54099.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmnb22 lamin B2 75.94(n)   30196  AJ005936.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LamC1 Lamin C 51.18(n)
    38.62(a)
      36615  NM_079018.3  NP_523742.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ifb-11 ifb-1 43.74(n)
    32.86(a)
      173976  NM_062735.4  NP_495136.1 


    ENSEMBL Gene Tree for LMNB2 (if available)
    TreeFam Gene Tree for LMNB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LMNB2 gene
    LMNB12  VIM2  INA2  LMNA2  PRPH2  NEFM2  DES2  NEFH2  
    GFAP2  
    10 SIMAP similar genes for LMNB2 using alignment to 2 protein entries:     LMNB2_HUMAN (see all proteins):
    LMNB1    LMNA    DES    KRTHB1    PRPH    KRTHB6
    VIM    K14    KRT4    KRT5

    Find genes that share paralogs with LMNB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LMNB2 (see all 859)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs575214991,2,,4
    CPartial acquired lipodystrophy (APLD)4 other12434027(-) TGTCCA/GCCACC 2 T A mis10--------
    VAR_0363704
    A colorectal cancer sample4--see VAR_0363702 R W mis40--------
    rs617264811,2,4
    Partial acquired lipodystrophy (APLD)4--see VAR_0310632 mis40--------
    rs2676076501,2
    Cuntested12444544(-) GGTCTC/TCCCAG 1 -- int10--------
    rs1219124971,2
    C,Fother12435150(-) GCGGCG/AGCGGC 2 /Q /R mis12Minor allele frequency- A:0.01NA EU 4867
    rs1858510261,2
    --2429907(+) AGTCAC/GGTGGC 1 -- ut310--------
    rs2017996701,2
    C--2429957(+) CAGAT-/AAAAAG 1 -- ut310--------
    rs2004293281,2
    --2430121(+) AACCA-/GATGTG 1 -- ut310--------
    rs7435781,2
    C,F,A,H--2430232(+) TGGCCT/CTGCAC 1 -- ut3125Minor allele frequency- C:0.41MN NS EA NA WA CSA 2715
    rs752025241,2
    C--2430255(+) AACTGA/CGGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LMNB2 (2427636 - 2456994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LMNB2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1372661CNV Deletion17803354
    esv2717894CNV Deletion23290073
    esv2717892CNV Deletion23290073
    esv2717896CNV Deletion23290073
    esv2717893CNV Deletion23290073
    nsv910655CNV Loss21882294
    dgv3637n71CNV Loss21882294
    nsv910660CNV Loss21882294
    esv23012CNV Loss19812545
    dgv3638n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): LMNB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMNB2
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 150341   
    OMIM disorders: 608709  
    UniProtKB/Swiss-Prot: LMNB2_HUMAN, Q03252
  • Partial acquired lipodystrophy (APLD) [MIM:608709]: A rare childhood disease characterized by loss of
    subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or
    excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show
    no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement
    deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 4 diseases for LMNB2:    
    About MalaCards
    barraquer-simons syndrome    reynolds syndrome    pelger-huet anomaly    lipodystrophy

    3 diseases from the University of Copenhagen DISEASES database for LMNB2:
    Lipodystrophy     Emery-Dreifuss muscular dystrophy     Pelger-Huet anomaly

    Find genes that share disorders with LMNB2           About GenesLikeMe

    1 Novoseek inferred disease relationship for LMNB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    partial lipodystrophy 83.6 1 17467691 (1)

    Genetic Association Database (GAD): LMNB2
    Human Genome Epidemiology (HuGE) Navigator: LMNB2 (3 documents)

    Export disorders for LMNB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LMNB2 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with LMNB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for a novel human lamin maps at a highly transcribed locus of chromosome 19 which replicates at the onset of S-phase. (PubMed id 1630457)1, 2, 3, 9 Biamonti G.... Falaschi A. (Mol. Cell. Biol. 1992)
    2. Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy. (PubMed id 16826530)1, 2, 9 Hegele R.A.... Durrington P.N. (Am. J. Hum. Genet. 2006)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. S-phase phosphorylation of lamin B2. (PubMed id 8543011)1, 9 Kill I.R. and Hutchison C.J. (FEBS Lett. 1995)
    8. Noncanonical DNA elements in the lamin B2 origin of DNA replication. (PubMed id 15611042)1, 9 Kusic J....Stefanovic D. (J. Biol. Chem. 2005)
    9. In vitro protein-DNA interactions at the human lamin B2 replication origin. (PubMed id 12902329)1, 9 Stefanovic D....Falaschi A. (J. Biol. Chem. 2003)
    10. Modular structure of the human lamin B2 replicator. (PubMed id 15024083)1, 9 PaixALo S....Biamonti G. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84823 HGNC: 6638 AceView: TIMM13andMKNK2 Ensembl:ENSG00000176619 euGenes: HUgn84823
    ECgene: LMNB2 H-InvDB: LMNB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LMNB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LMNB2 gene:
    Search GeneIP for patents involving LMNB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNB2
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LMNB2   OriGene RNAi products in human, mouse, rat for LMNB2  
     OriGene qPCR primer pairs and template standards for LMNB2   OriGene Protein Over-expression Lysate for LMNB2  
     OriGene MassSpec something-or-other for LMNB2   OriGene clones in human, mouse for LMNB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for LMNB2   OriGene Purified Protein for LMNB2  
     OriGene ORF clones in mouse, rat for LMNB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LMNB2   OriGene Custom Protein Services for LMNB2  

     
     
     Block miRNA regulation of human, mouse, rat LMNB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LMNB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMNB2 Predesigned siRNA for gene silencing in human, mouse, rat LMNB2
     QuantiFast Probe-based Assays in human, mouse, rat LMNB2 QuantiTect SYBR Green Assays in human, mouse, rat LMNB2
     PCR Arrays including human, mouse, rat LMNB2 Search Chromatin IP Primers for LMNB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNB2  GeneGlobe Interaction Network for LMNB2
     Regulatory tfbs in LMNB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LMNB2 GenScript cDNA clones with any tag delivered in your preferred vector for LMNB2
     GenScript Custom Assay Services for LMNB2 GenScript Custom overexpressing Cell Line Services for LMNB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for LMNB2 
    (Lamin B2)

     Search Tocris compounds for LMNB2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LMNB2 antibodies
     LMNB2 lysates
     Antibodies for LMNB2
     See all of Abcam's Antibodies, Kits and Proteins for LMNB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LMNB2
     Antibodies for LMNB2
     ELISAs for LMNB2
     CLIAs for LMNB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for LMNB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNB2
     SwitchGear 3'UTR luciferase reporter plasmids for LMNB2
     SwitchGear Promoter luciferase reporter plasmids for LMNB2
     ThermoFisher Antibody for LMNB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMNB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMNB2
     LSBio Antibodies in human, mouse, rat for LMNB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for LMNB2
      Search eBioscience for proteins for LMNB2
      Search eBioscience for elisas for LMNB2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LMNB2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4