External Ids for LMNB2 Gene
Previous HGNC Symbols for LMNB2 Gene
Previous GeneCards Identifiers for LMNB2 Gene
This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
GeneCards Summary for LMNB2 Gene
LMNB2 (Lamin B2) is a Protein Coding gene. Diseases associated with LMNB2 include epilepsy, progressive myoclonic, 9 and lipodystrophy, partial, acquired. Among its related pathways are Degradation of the extracellular matrix and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is LMNTD1.
UniProtKB/Swiss-Prot for LMNB2 Gene
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.