External Ids for LMNB1 Gene
Previous GeneCards Identifiers for LMNB1 Gene
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for LMNB1 Gene
LMNB1 (Lamin B1) is a Protein Coding gene. Diseases associated with LMNB1 include Leukodystrophy, Adult-Onset, Autosomal Dominant and Leukodystrophy. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity and phospholipase binding. An important paralog of this gene is LMNB2.
UniProtKB/Swiss-Prot for LMNB1 Gene
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.