External Ids for LMNB1 Gene
Previous GeneCards Identifiers for LMNB1 Gene
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
GeneCards Summary for LMNB1 Gene
LMNB1 (Lamin B1) is a Protein Coding gene. Diseases associated with LMNB1 include leukodystrophy, adult-onset, autosomal dominant and reynolds syndrome. Among its related pathways are Cell Cycle, Mitotic and Cytoskeletal Signaling. GO annotations related to this gene include structural molecule activity and phospholipase binding. An important paralog of this gene is LMNB2.
UniProtKB/Swiss-Prot for LMNB1 Gene
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin