External Ids for LMNB1 Gene
Previous GeneCards Identifiers for LMNB1 Gene
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for LMNB1 Gene
LMNB1 (Lamin B1) is a Protein Coding gene. Diseases associated with LMNB1 include Leukodystrophy, Adult-Onset, Autosomal Dominant and Leukodystrophy. Among its related pathways are Packaging Of Telomere Ends and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include structural molecule activity and phospholipase binding. An important paralog of this gene is LMNB2.
UniProtKB/Swiss-Prot for LMNB1 Gene
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.