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LMNA Gene

protein-coding   GIFtS: 75
GCID: GC01P156053

Lamin A/C

(Previous names: cardiomyopathy, dilated 1A (autosomal dominant), limb girdle...)
(Previous symbols: LMN1, CMD1A, LGMD1B, PRO1, LMNL1)
  See LMNA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lamin A/C1 2     70 KDa Lamin2
LMN11 2 3 5     CDCD12
CMD1A1 2 5     CDDC2
LGMD1B1 2 5     CMT2B12
LMNL11 2     FPL2
PRO11 2     FPLD2
Lamin A/C-Like 11 2     IDC2
EMD22 5     LDP12
FPLD22 5     LFP2
HGPS2 5     LMNC2
Cardiomyopathy, Dilated 1A (Autosomal Dominant)1     lamin2
Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant)1     prelamin-A/C2
Progeria 1 (Hutchinson-Gilford Type)1     Renal Carcinoma Antigen NY-REN-322

External Ids:    HGNC: 66361   Entrez Gene: 40002   Ensembl: ENSG000001607897   OMIM: 1503305   UniProtKB: P025453   
ORGUL members:         

Export aliases for LMNA gene to outside databases

Previous GC identifers: GC01P153921 GC01P151817 GC01P152830 GC01P153301 GC01P152897 GC01P154318 GC01P127446


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMNA Gene:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.
The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina
matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be
involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A
and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy,
dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. (provided by
RefSeq, Apr 2012)

GeneCards Summary for LMNA Gene:
LMNA (lamin A/C) is a protein-coding gene. Diseases associated with LMNA include laminopathy type decaudain-vigouroux, and lmna-related cardiocutaneous progeria syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is DES.

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
maintain the volume and strength of skeletal muscle and bone
Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
senescence

Gene Wiki entry for LMNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMNA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMNA promoter sequence
   Search Chromatin IP Primers for LMNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

LMNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156053:  view genomic region     (about GC identifiers)

Start:
156,052,364 bp from pter      End:
156,109,880 bp from pter
Size:
57,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545 (See protein sequence)
Recommended Name: Prelamin-A/C precursor  
Size: 664 amino acids; 74139 Da
Subunit: Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1
and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43 (By similarity). Proteolytically processed
isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP; may
regulate MLIP localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability.
Interacts with SUV39H1; the interaction increases stability of SUV39H1
Miscellaneous: There are three types of lamins in human cells: A, B, and C
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Sequence caution: Sequence=CAA27173.1; Type=Frameshift; Positions=582;
Selected PDB 3D structures from and Proteopedia for LMNA (see all 9):
1IFR (3D)        1IVT (3D)        1X8Y (3D)        2XV5 (3D)        2YPT (3D)        3GEF (3D)    
Secondary accessions: B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3
Q969I8 Q96JA2
Alternative splicing: 6 isoforms:  P02545-1   P02545-2   P02545-3   P02545-4   P02545-5   P02545-6   (Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage)

Explore the universe of human proteins at neXtProt for LMNA: NX_P02545

Explore proteomics data for LMNA at MOPED

Post-translational modifications: 

  • Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in
    regulating lamin associations1
  • Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The
    prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the
    last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15
    C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these
    blocks cleavage1
  • Sumoylation is necessary for the localization to the nuclear envelope1
  • Farnesylation of prelamin-A/C facilitates nuclear envelope targeting1
  • Ubiquitination2 at Lys78, Lys108, Lys135, Lys144, Lys171, Lys181, Lys201, Lys208, Lys265, Lys270,
                                 Lys311, Lys378, Lys470, Lys486
  • Modification sites at PhosphoSitePlus

  • See LMNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001244303.1  NP_001269553.1  NP_001269554.1  NP_001269555.1  NP_005563.1  NP_733821.1  NP_733822.1  

    ENSEMBL proteins: 
     ENSP00000357284   ENSP00000357283   ENSP00000357282   ENSP00000395597   ENSP00000424518  
     ENSP00000357280   ENSP00000426535   ENSP00000421821   ENSP00000424977   ENSP00000292304  
     ENSP00000355292   ENSP00000376164  
    Reactome Protein details: P02545

    LMNA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for LMNA
    OriGene Protein Over-expression Lysate for LMNA
    OriGene MassSpec for LMNA
    OriGene Custom Protein Services for LMNA
    GenScript Custom Purified and Recombinant Proteins Services for LMNA
    Novus Biologicals LMNA Protein
    Novus Biologicals LMNA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LMNA
    Cloud-Clone Corp. Proteins for LMNA

     
    Search eBioscience for Proteins for LMNA 

    LMNA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNA  (lamin A/C)
    OriGene Antibodies for LMNA
    OriGene Custom Antibody Services for LMNA
    Novus Biologicals LMNA Antibodies
    Abcam antibodies for LMNA (Q6UYC3, P20700, P02545)
    Cloud-Clone Corp. Antibodies for LMNA
    ThermoFisher Antibody for LMNA
    LSBio Antibodies in human, mouse, rat for LMNA

    LMNA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMNA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMNA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMNA
    Cloud-Clone Corp. CLIAs for LMNA
    Search eBioscience for ELISAs for LMNA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF5: Intermediate filaments type V, lamins

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry P02545

    ProtoNet protein and cluster: P02545

    2 Blocks protein domains:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with LMNA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMNA_HUMAN, P02545
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
    nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
    chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
    nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
    of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
    osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
    maintain the volume and strength of skeletal muscle and bone
    Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
    damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
    senescence

         Genatlas biochemistry entry for LMNA:
    lamin,types A and C,common gene,alternatively spliced isoforms

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS3453101
    GO:0005515protein binding IPI10381623
         
    Find genes that share ontologies with LMNA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LMNA:
     Increased S DNA content  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Lmna) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with LMNA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LMNA: Lmnatm6Lgf Lmnatm1Stw Lmnatm4Lgf Lmnatm5Lgf Lmnatm1Lgf Lmnatm2Lgf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMNA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMNA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMNA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMNA

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMNA:
    hsa-mir-615-3p (MIRT040169), hsa-mir-296-3p (MIRT038445), hsa-let-7a-5p (MIRT052409), hsa-mir-340-5p (MIRT019532), hsa-mir-124-3p (MIRT022394), hsa-mir-9-5p (MIRT021388), hsa-let-7e-5p (MIRT051592)

    Block miRNA regulation of human, mouse, rat LMNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMNA

    Clone
    Products:
         
    OriGene clones in human, mouse for LMNA (see all 18)
    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    Sino Biological Human cDNA Clone for LMNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Addgene plasmids for LMNA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMNA
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMNA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMNA_HUMAN, P02545: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of
    prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the
    farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for
    proper localization of non-farnesylated prelamin-A/C
    LMNA_HUMAN, P02545: Isoform C: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS3453101
    GO:0005638lamin filament TAS10080180
    GO:0005652nuclear lamina TAS8344919
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with LMNA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LMNA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    Breakdown of the nuclear lamina0.00
    FAS pathway and Stress induction of HSP regulation0.44
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    5Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00
    Clearance of Nuclear Envelope Membranes from Chromatin0.00


    Find genes that share SuperPaths with LMNA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LMNA
        Caspase Cascade
    Granzyme Pathway
    Fas Signaling

    3 Cell Signaling Technology (CST) Pathways for LMNA
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for LMNA
        Adipogenesis
    FAS pathway and Stress induction of HSP regulation
    Arrhythmogenic right ventricular cardiomyopathy
    Caspase cascade in apoptosis


    1 Reactome Pathway for LMNA
        XBP1(S) activates chaperone genes

    1 PharmGKB Pathway for LMNA
        Antiarrhythmic Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for LMNA):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMNA (P025451, 2, 3 ENSP000003572834) via UniProtKB, MINT, STRING, and/or I2D (see all 1002) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI31, 2, 3, ENSP000003854794EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    HIST2H3DQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000230624Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000235439Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=2 STRING: ENSP00000349960
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000332455
    H2AFXP161042, 3, ENSP000003643104MINT-8361862 MINT-7899812 I2D: score=2 STRING: ENSP00000364310
    MYH9P355792, 3MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 
    NUP153P497902, 3, ENSP000002620774MINT-7945693 MINT-7893777 I2D: score=1 STRING: ENSP00000262077
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    UCHL5Q9Y5K52, 3, ENSP000003564254MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356425
    EXOC5O004712, 3MINT-7945693 MINT-7947479 I2D: score=4 
    PCBP1Q153652, 3, ENSP000003055564MINT-7947479 I2D: score=2 STRING: ENSP00000305556
    EFTUD2Q150292, 3MINT-7945693 MINT-7947479 I2D: score=1 
    EIF3IQ133472, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HSP90B1P146252, 3MINT-7945693 MINT-7947479 I2D: score=1 
    RBBP4Q090282, 3, ENSP000003625924MINT-7947479 I2D: score=1 STRING: ENSP00000362592
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    TRIM28Q132632, 3MINT-7945693 MINT-7947479 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    CDK1P064932, 3MINT-7945693 I2D: score=2 
    ACTG1P632612, 3MINT-7899812 I2D: score=1 
    HIST1H1DP164022, 3MINT-7899812 I2D: score=1 
    IKQ131232, 3MINT-7945693 I2D: score=1 
    MORF4L2Q150142, 3MINT-7945693 I2D: score=1 
    RBM10P981752, 3MINT-7945693 I2D: score=1 
    SRSF2Q011302, 3MINT-7945693 I2D: score=1 
    TNPO1Q929732, 3MINT-7947479 I2D: score=1 
    YWHAGP619812, 3MINT-7899812 I2D: score=1 
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    ENSG00000230108P013753I2D: score=1 
    MORF4L1Q9UBU82, 3, ENSP000003313104MINT-7945693 MINT-8361862 MINT-8329389 MINT-8329289 I2D: score=1 STRING: ENSP00000331310
    PASKQ96RG21, 2, 3, ENSP000002340404EBI-351935,EBI-1042651 MINT-8148942 MINT-8148953 I2D: score=1 STRING: ENSP00000234040
    YWHAZP631041, 2, 3, ENSP000003095034EBI-351935,EBI-347088 MINT-3297814 MINT-7899812 I2D: score=1 STRING: ENSP00000309503
    TMPOP421662, 3, ENSP000002667324MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000266732
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    AIMP2Q131552, 3, ENSP000002230294MINT-8145495 I2D: score=1 STRING: ENSP00000223029
    ALOX12P180541, 3, ENSP000002515354EBI-351935,EBI-1633210 I2D: score=4 STRING: ENSP00000251535
    SMAD3P840222, 3, ENSP000003329734MINT-51248 I2D: score=3 STRING: ENSP00000332973
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    BRCA1P383982MINT-8361862 MINT-8329389 MINT-8329289
    BRCA2P515872MINT-8361862 MINT-8329389 MINT-8329289
    DCTN2Q135612, ENSP000004089104MINT-7945693 MINT-7947479 STRING: ENSP00000408910
    HNRNPA2B1P226262MINT-7945693 MINT-7899812 MINT-7947479
    HNRNPCP079102MINT-7945693 MINT-7899812 MINT-7947479
    PALB2Q86YC22MINT-8361862 MINT-8329389 MINT-8329289
    PRKDCP785272, ENSP000003134204MINT-7945693 MINT-7947479 STRING: ENSP00000313420
    RAD51Q066092MINT-8361862 MINT-8329389 MINT-8329289
    RALYQ9UKM92MINT-7945693 MINT-7899812 MINT-7947479
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    VIMP086702MINT-7945693 MINT-7899812 MINT-7947479
    TOR1AIP1Q5JTV83, ENSP000002715834I2D: score=4 STRING: ENSP00000271583
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    ALOX12BO753423, ENSP000003151674I2D: score=2 STRING: ENSP00000315167
    FOSP011003, ENSP000003062454I2D: score=2 STRING: ENSP00000306245
    PCGF2P352273, ENSP000003540334I2D: score=2 STRING: ENSP00000354033
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ING1Q9UK533, ENSP000003649294I2D: score=1 STRING: ENSP00000364929
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    STACQ994693, ENSP000002731834I2D: score=1 STRING: ENSP00000273183
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    UNC13DQ70J993, ENSP000002075494I2D: score=1 STRING: ENSP00000207549
    EMDP504023, ENSP000003588574I2D: score=4 STRING: ENSP00000358857
    LMNB1P207003, ENSP000002613664I2D: score=7 STRING: ENSP00000261366
    PRKCAP172523, ENSP000002843844I2D: score=3 STRING: ENSP00000284384
    RB1P064003, ENSP000002671634I2D: score=4 STRING: ENSP00000267163
    SYNE1Q8NF913, ENSP000002653684I2D: score=2 STRING: ENSP00000265368
    LMNB2Q032523, ENSP000003270544I2D: score=1 STRING: ENSP00000327054
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
    CASP6P552123, ENSP000002651644I2D: score=1 STRING: ENSP00000265164
    NARFQ9UHQ13, ENSP000003098994I2D: score=2 STRING: ENSP00000309899
    SREBF1P369563, ENSP000003480694I2D: score=3 STRING: ENSP00000348069
    TOR1AO146563, ENSP000003457194I2D: score=1 STRING: ENSP00000345719
    URB2Q141463, ENSP000002582434I2D: score=3 STRING: ENSP00000258243
    ZNF239Q166003, ENSP000003077744I2D: score=2 STRING: ENSP00000307774
    CTCFP497113, ENSP000002640104I2D: score=1 STRING: ENSP00000264010
    EGFP011333, ENSP000002651714I2D: score=2 STRING: ENSP00000265171
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    BNIP3LO602383, ENSP000003700034I2D: score=1 STRING: ENSP00000370003
    MRPS26Q9BYN83, ENSP000003696824I2D: score=1 STRING: ENSP00000369682
    CDH1P128303, ENSP000002617694I2D: score=2 STRING: ENSP00000261769
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    MRGBPQ9NV563, ENSP000003595184I2D: score=1 STRING: ENSP00000359518
    MYCP011063, ENSP000003672074I2D: score=4 STRING: ENSP00000367207
    KAT5Q929933, ENSP000003403304I2D: score=5 STRING: ENSP00000340330
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    ACTL6AO960192MINT-7945693 MINT-7947479
    ACTR1AP611632MINT-7945693 MINT-7947479
    ACTR2P611602MINT-7945693 MINT-7947479
    ADNPQ9H2P02MINT-7945693 MINT-7947479
    AHNAKQ096662MINT-7945693 MINT-7947479
    ANAPC1Q9H1A42MINT-7945693 MINT-7947479
    ANLNQ9NQW62MINT-7945693 MINT-7947479
    AP1B1Q105672MINT-7945693 MINT-7947479
    ARCN1P484442MINT-7945693 MINT-7947479
    ARHGEF1Q928882MINT-7945693 MINT-7947479
    ARHGEF2Q929742MINT-7945693 MINT-7947479
    ARID1AO144972MINT-7945693 MINT-7947479
    AURKBQ96GD42MINT-7945693 MINT-7947479
    BAZ1AQ9NRL22MINT-7945693 MINT-7947479
    BCAS2O759342MINT-7945693 MINT-7947479
    BCLAF1Q9NYF82MINT-7945693 MINT-7947479
    BRD8Q9H0E92MINT-7945693 MINT-7947479
    BTAF1O149812MINT-7945693 MINT-7947479
    BUB1O436832MINT-7945693 MINT-7947479
    BUB1BO605662MINT-7945693 MINT-7947479
    BUB3O436842MINT-7945693 MINT-7947479
    BZW1Q7L1Q62MINT-7945693 MINT-7947479
    CAPGP401212MINT-7945693 MINT-7947479
    CAPZA1P529072MINT-7945693 MINT-7947479
    CCNB1P146352MINT-7945693 MINT-7947479
    CCT2P783712MINT-7945693 MINT-7947479
    CCT3P493682MINT-7945693 MINT-7947479
    CCT4P509912MINT-7945693 MINT-7947479
    CCT5P486432MINT-7945693 MINT-7947479
    CCT6AP402272MINT-7945693 MINT-7947479
    CCT7Q998322MINT-7945693 MINT-7947479
    CCT8P509902MINT-7945693 MINT-7947479
    CDC16Q130422MINT-7945693 MINT-7947479
    CDC23Q9UJX22MINT-7945693 MINT-7947479
    CDC27P302602MINT-7945693 MINT-7947479
    CDC73Q6P1J92MINT-7945693 MINT-7947479
    CDK9P507502MINT-7945693 MINT-7947479
    CDKN2AIPQ9NXV62MINT-7945693 MINT-7947479
    CHD1LQ86WJ12MINT-7945693 MINT-7947479
    CHD8Q9HCK82MINT-7945693 MINT-7947479
    CHEK1O147572MINT-7945693 MINT-7947479
    CKAP5Q140082MINT-7945693 MINT-7947479
    COPAP536212MINT-7945693 MINT-7947479
    COPB1P536182MINT-7945693 MINT-7947479
    COPB2P356062MINT-7945693 MINT-7947479
    COPG1Q9Y6782MINT-7945693 MINT-7947479
    COPG2Q9UBF22MINT-7945693 MINT-7947479
    COPS5Q929052MINT-7945693 MINT-7947479
    CPSF2Q9P2I02MINT-7945693 MINT-7947479
    CPSF3Q9UKF62MINT-7945693 MINT-7947479
    CPSF7Q8N6842MINT-7945693 MINT-7947479
    CSE1LP550602MINT-7945693 MINT-7947479
    CSTF3Q129962MINT-7945693 MINT-7947479
    CUL1Q136162MINT-7945693 MINT-7947479
    DDX17Q928412MINT-7945693 MINT-7947479
    DDX19AQ9NUU72MINT-7945693 MINT-7947479
    DDX19BQ9UMR22MINT-7945693 MINT-7947479
    DDX39AO001482MINT-7945693 MINT-7947479
    DDX3XO005712MINT-7945693 MINT-7947479
    DDX41Q9UJV92MINT-7945693 MINT-7947479
    DDX42Q86XP32MINT-7945693 MINT-7947479
    DDX5P178442MINT-7945693 MINT-7947479
    DEPDC7Q96QD52MINT-7945693 MINT-7947479
    DFNA5O604432MINT-7945693 MINT-7947479
    DIAPH1O606102MINT-7945693 MINT-7947479
    DIDO1Q9BTC02MINT-7945693 MINT-7947479
    DMAP1Q9NPF52MINT-7945693 MINT-7947479
    DNAJA1P316892MINT-7945693 MINT-7947479
    DNM1LO004292MINT-7945693 MINT-7947479
    DNM2P505702MINT-7945693 MINT-7947479
    DRG1Q9Y2952MINT-7945693 MINT-7947479
    DSPP159242MINT-7945693 MINT-7947479
    DYNC1H1Q142042MINT-7945693 MINT-7947479
    DYNC1LI2O432372MINT-7945693 MINT-7947479
    EEF1A1P681042MINT-7945693 MINT-7947479
    EHD1Q9H4M92MINT-7945693 MINT-7947479
    EHD4Q9H2232MINT-7945693 MINT-7947479
    EIF2S3P410912MINT-7945693 MINT-7947479
    EIF3GO758212MINT-7945693 MINT-7947479
    EIF4A1P608422MINT-7945693 MINT-7947479
    EIF4A3P389192MINT-7945693 MINT-7947479
    EIF4G2P783442MINT-7945693 MINT-7947479
    EIF5BO608412MINT-7945693 MINT-7947479
    ELAVL1Q157172MINT-7945693 MINT-7947479
    ENAHQ8N8S72MINT-7945693 MINT-7947479
    ENSG00000183311P074372MINT-7945693 MINT-7947479
    ENSG00000206490Q8NE712MINT-7945693 MINT-7947479
    ENSG00000224156P074372MINT-7945693 MINT-7947479
    ENSG00000225989Q8NE712MINT-7945693 MINT-7947479
    ENSG00000227739P074372MINT-7945693 MINT-7947479
    ENSG00000229684P074372MINT-7945693 MINT-7947479
    ENSG00000231129Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232169Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232421P074372MINT-7945693 MINT-7947479
    ENSG00000232575P074372MINT-7945693 MINT-7947479
    ENSG00000235067P074372MINT-7945693 MINT-7947479
    ENSG00000236149Q8NE712MINT-7945693 MINT-7947479
    ENSG00000236342Q8NE712MINT-7945693 MINT-7947479
    EPPK1P581072MINT-7945693 MINT-7947479
    EPS8L2Q9H6S32MINT-7945693 MINT-7947479
    ETF1P624952MINT-7945693 MINT-7947479
    ETV6P412122MINT-7945693 MINT-7947479
    EXOC2Q96KP12MINT-7945693 MINT-7947479
    EXOC4Q96A652MINT-7945693 MINT-7947479
    EXOC7Q9UPT52MINT-7945693 MINT-7947479
    EXOSC10Q017802MINT-7945693 MINT-7947479
    FAM129BQ96TA12MINT-7945693 MINT-7947479
    FANCIQ9NVI12MINT-7945693 MINT-7947479
    FASNP493272MINT-7945693 MINT-7947479
    FEN1P397482MINT-7945693 MINT-7947479
    FERMT1Q9BQL62MINT-7945693 MINT-7947479
    FHOD1Q9Y6132MINT-7945693 MINT-7947479
    FUSP356372MINT-7945693 MINT-7947479
    GATAD2AQ86YP42MINT-7945693 MINT-7947479
    GCN1L1Q926162MINT-7945693 MINT-7947479
    GEMIN4P576782MINT-7945693 MINT-7947479
    GTF2IP783472MINT-7945693 MINT-7947479
    GTF3C2Q8WUA42MINT-7945693 MINT-7947479
    GULP1Q9UBP92MINT-7945693 MINT-7947479
    HBS1LQ9Y4502MINT-7945693 MINT-7947479
    HDAC1Q135472MINT-7945693 MINT-7947479
    HDAC2Q927692MINT-7945693 MINT-7947479
    HDLBPQ003412MINT-7945693 MINT-7947479
    HELLSQ9NRZ92MINT-7945693 MINT-7947479
    HIP1RO751462MINT-7945693 MINT-7947479
    HIRAP541982MINT-7945693 MINT-7947479
    HLTFQ145272MINT-7945693 MINT-7947479
    HNRNPFP525972MINT-7945693 MINT-7947479
    HNRNPH1P319432MINT-7945693 MINT-7947479
    HNRNPKP619782MINT-7945693 MINT-7947479
    HNRNPMP522722MINT-7945693 MINT-7947479
    HNRNPUQ008392MINT-7945693 MINT-7947479
    HSP90AA1P079002MINT-7945693 MINT-7947479
    HSP90AB1P082382MINT-7945693 MINT-7947479
    HSPA12AO433012MINT-7945693 MINT-7947479
    HSPA5P110212MINT-7945693 MINT-7947479
    HSPA8P111422MINT-7945693 MINT-7947479
    HSPB1P047922MINT-7945693 MINT-7947479
    HSPD1P108092MINT-7945693 MINT-7947479
    ILF2Q129052MINT-7945693 MINT-7947479
    INTS1Q8N2012MINT-7945693 MINT-7947479
    INTS3Q68E012MINT-7945693 MINT-7947479
    IPO5O004102MINT-7945693 MINT-7947479
    IPO9Q96P702MINT-7945693 MINT-7947479
    IQGAP1P469402MINT-7945693 MINT-7947479
    KDM1AO603412MINT-7945693 MINT-7947479
    KHDRBS1Q076662MINT-7945693 MINT-7947479
    KIF11P527322MINT-7945693 MINT-7947479
    KIF21AQ7Z4S62MINT-7945693 MINT-7947479
    KIF2CQ996612MINT-7945693 MINT-7947479
    KIF4AO952392MINT-7945693 MINT-7947479
    KPNB1Q149742MINT-7945693 MINT-7947479
    LATS2Q9NRM72, ENSP000003720354MINT-8313510 STRING: ENSP00000372035
    LIMS1P480592MINT-7945693 MINT-7947479
    LRRC40Q9H9A62MINT-7945693 MINT-7947479
    LRWD1Q9UFC02MINT-7945693 MINT-7947479
    MAD1L1Q9Y6D92MINT-7945693 MINT-7947479
    MAP2K7O147332MINT-7945693 MINT-7947479
    MATR3P432432MINT-7945693 MINT-7947479
    MDN1Q9NU222MINT-7945693 MINT-7947479
    MED4Q9NPJ62MINT-7945693 MINT-7947479
    MLH1P406922, ENSP000002317904MINT-7945693 STRING: ENSP00000231790
    MRE11AP499592MINT-7945693 MINT-7947479
    MSH2P432462MINT-7945693 MINT-7947479
    MSH6P527012MINT-7945693 MINT-7947479
    MTA2O947762MINT-7945693 MINT-7947479
    MVPQ147642MINT-7945693 MINT-7947479
    MYO15BQ96JP22MINT-7945693 MINT-7947479
    NACC1Q96RE72MINT-7945693 MINT-7947479
    NBNO609342MINT-7945693 MINT-7947479
    NCAPD2Q150212MINT-7945693 MINT-7947479
    NCAPHQ150032MINT-7945693 MINT-7947479
    NCOR1O753762MINT-7945693 MINT-7947479
    NDC80O147772MINT-7945693 MINT-7947479
    NELFBQ8WX922MINT-7945693 MINT-7947479
    NIPBLQ6KC792MINT-7945693 MINT-7947479
    NONOQ152332MINT-7945693 MINT-7947479
    NPM1P067482MINT-7899812 MINT-7947479
    NSFP464592MINT-7945693 MINT-7947479
    NSUN5Q96P112MINT-7945693 MINT-7947479
    NUDCQ9Y2662MINT-7945693 MINT-7947479
    NUF2Q9BZD42MINT-7945693 MINT-7947479
    NUP155O756942MINT-7945693 MINT-7947479
    ORC2Q134162MINT-7945693 MINT-7947479
    ORC3Q9UBD52MINT-7945693 MINT-7947479
    OXSR1O957472MINT-7945693 MINT-7947479
    PAK4O960132MINT-7945693 MINT-7947479
    PARVAQ9NVD72MINT-7945693 MINT-7947479
    PARVBQ9HBI12MINT-7945693 MINT-7947479
    PCBP2Q153662MINT-7945693 MINT-7947479
    PDLIM7Q9NR122MINT-7945693 MINT-7947479
    PFKMP082372MINT-7945693 MINT-7947479
    PFKPQ018132MINT-7945693 MINT-7947479
    PHGDHO431752MINT-7945693 MINT-7947479
    PICALMQ134922MINT-7945693 MINT-7947479
    PKN2Q165132MINT-7945693 MINT-7947479
    PLECQ151492MINT-7945693 MINT-7947479
    PLK1P533502MINT-7945693 MINT-7947479
    PLRG1O436602MINT-7945693 MINT-7947479
    PNNQ9H3072MINT-7945693 MINT-7947479
    POLD1P283402MINT-7945693 MINT-7947479
    POLR1CO151602MINT-7945693 MINT-7947479
    PPP1CAP621362MINT-7945693 MINT-7947479
    PPP2R1AP301532MINT-7945693 MINT-7947479
    PRPF19Q9UMS42MINT-7945693 MINT-7947479
    PRPF6O949062MINT-7945693 MINT-7947479
    PRPF8Q6P2Q92MINT-7945693 MINT-7947479
    PSMC1P621912MINT-7945693 MINT-7947479
    PSMC2P359982MINT-7945693 MINT-7947479
    PSMC3P179802MINT-7945693 MINT-7947479
    PSMC4P436862MINT-7945693 MINT-7947479
    PSMC5P621952MINT-7945693 MINT-7947479
    PSMC6P623332MINT-7945693 MINT-7947479
    PSMD1Q994602MINT-7945693 MINT-7947479
    PSMD11O002312MINT-7945693 MINT-7947479
    PSMD12O002322MINT-7945693 MINT-7947479
    PSMD13Q9UNM62MINT-7945693 MINT-7947479
    PSMD2Q132002MINT-7945693 MINT-7947479
    PSMD3O432422MINT-7945693 MINT-7947479
    PTBP1P265992MINT-7945693 MINT-7947479
    RACGAP1Q9H0H52MINT-7945693 MINT-7947479
    RAD18Q9NS912MINT-7945693 MINT-7947479
    RAD50Q928782MINT-7945693 MINT-7947479
    RANBP2P497922MINT-7945693 MINT-7947479
    RANGAP1P460602MINT-7945693 MINT-7947479
    RBBP5Q152912MINT-7945693 MINT-7947479
    RBBP7Q165762MINT-7945693 MINT-7947479
    RBM17Q96I252MINT-7945693 MINT-7947479
    RBM39Q144982MINT-7945693 MINT-7947479
    RBM4Q9BWF32MINT-7945693 MINT-7947479
    RBM45Q8IUH32MINT-7945693 MINT-7947479
    RBMXP381592MINT-7945693 MINT-7947479
    RCOR1Q9UKL02MINT-7945693 MINT-7947479
    RFC2P352502MINT-7945693 MINT-7947479
    RFC3P409382MINT-7945693 MINT-7947479
    RFC4P352492MINT-7945693 MINT-7947479
    RFC5P409372MINT-7945693 MINT-7947479
    RIF1Q5UIP02MINT-7945693 MINT-7947479
    ROCK2O751162MINT-7945693 MINT-7947479
    RPL13P263732MINT-7945693 MINT-7947479
    RPL22P352682MINT-7945693 MINT-7947479
    RPL31P628992MINT-7945693 MINT-7947479
    RPLP0P053882MINT-7945693 MINT-7947479
    RPS3P233962MINT-7945693 MINT-7899812
    RPS6KA4O756762MINT-7945693 MINT-7947479
    RPS6KB2Q9UBS02MINT-7945693 MINT-7947479
    RTCBQ9Y3I02MINT-7945693 MINT-7947479
    RUVBL1Q9Y2652MINT-7945693 MINT-7947479
    RUVBL2Q9Y2302MINT-7945693 MINT-7947479
    SART1O432902MINT-7945693 MINT-7947479
    SCYL2Q6P3W72MINT-7945693 MINT-7947479
    SEH1LQ96EE32MINT-7945693 MINT-7947479
    SEPT9Q9UHD82MINT-7945693 MINT-7947479
    SETXQ7Z3332MINT-7945693 MINT-7947479
    SF3A1Q154592MINT-7945693 MINT-7947479
    SF3A3Q128742MINT-7945693 MINT-7947479
    SF3B1O755332MINT-7945693 MINT-7947479
    SF3B2Q134352MINT-7945693 MINT-7947479
    SF3B3Q153932MINT-7945693 MINT-7947479
    SF3B6Q9Y3B42MINT-7945693 MINT-7947479
    SFPQP232462MINT-7945693 MINT-7947479
    SHROOM3Q8TF722MINT-7945693 MINT-7947479
    SMARCA5O602642MINT-7945693 MINT-7947479
    SMARCAD1Q9H4L72MINT-7945693 MINT-7947479
    SMARCB1Q128242MINT-7945693 MINT-7947479
    SMARCC1Q929222MINT-7945693 MINT-7947479
    SMARCC2Q8TAQ22MINT-7945693 MINT-7947479
    SMARCD1Q96GM52MINT-7945693 MINT-7947479
    SMARCE1Q969G32MINT-7945693 MINT-7947479
    SMC1AQ146832MINT-7945693 MINT-7947479
    SMC2O953472MINT-7945693 MINT-7947479
    SMC3Q9UQE72MINT-7945693 MINT-7947479
    SMC4Q9NTJ32MINT-7945693 MINT-7947479
    SMCHD1A6NHR92MINT-7945693 MINT-7947479
    SMN1Q166372MINT-7945693 MINT-7947479
    SMN2Q166372MINT-7945693 MINT-7947479
    SNRNP200O756432MINT-7945693 MINT-7947479
    SNRNP40Q96DI72MINT-7945693 MINT-7947479
    SNRNP70P086212MINT-7945693 MINT-7947479
    SNRPD3P623182MINT-7945693 MINT-7947479
    SPATA5Q8NB902MINT-7945693 MINT-7947479
    SPTAN1Q138132MINT-7945693 MINT-7947479
    SPTBN1Q010822MINT-7945693 MINT-7947479
    SRP54P610112MINT-7945693 MINT-7947479
    SRP68Q9UHB92MINT-7945693 MINT-7947479
    SRP72O760942MINT-7945693 MINT-7947479
    SRSF1Q079552MINT-7945693 MINT-7947479
    SRSF7Q166292MINT-7945693 MINT-7947479
    SUGT1Q9Y2Z02MINT-7945693 MINT-7947479
    SYMPKQ927972MINT-7945693 MINT-7947479
    TARDBPQ131482MINT-7945693 MINT-7947479
    TBL1XR1Q9BZK72MINT-7945693 MINT-7947479
    TCP1P179872MINT-7945693 MINT-7947479
    THRAP3Q9Y2W12MINT-7945693 MINT-7947479
    TIAL1Q010852MINT-7945693 MINT-7947479
    TLN1Q9Y4902MINT-7945693 MINT-7947479
    TRAP1Q129312MINT-7945693 MINT-7947479
    TRIP13Q156452MINT-7945693 MINT-7947479
    TRUB1Q8WWH52MINT-7945693 MINT-7947479
    TSG101Q998162MINT-7945693 MINT-7947479
    TUBA4AP683662MINT-7945693 MINT-7947479
    TUBBP074372MINT-7945693 MINT-7947479
    TUBB4BP683712MINT-7945693 MINT-7947479
    TUBG1P232582MINT-7945693 MINT-7947479
    TUBGCP2Q9BSJ22MINT-7945693 MINT-7947479
    TUBGCP3Q96CW52MINT-7945693 MINT-7947479
    TWF1Q127922MINT-7945693 MINT-7947479
    U2AF1Q010812MINT-7945693 MINT-7947479
    U2AF2P263682MINT-7945693 MINT-7947479
    U2SURPO150422MINT-7945693 MINT-7947479
    UBA5Q9GZZ92MINT-7945693 MINT-7947479
    UBE2MP610812MINT-7945693 MINT-7947479
    UBE2NP610882MINT-7945693 MINT-7947479
    UBL4AP114412MINT-7945693 MINT-7947479
    UNC45AQ9H3U12MINT-7945693 MINT-7947479
    UPF1Q929002MINT-7945693 MINT-7947479
    UPF2Q9HAU52MINT-7945693 MINT-7947479
    USP39Q53GS92MINT-7945693 MINT-7947479
    VASPP505522MINT-7945693 MINT-7899812
    VPS33BQ9H2672MINT-7945693 MINT-7947479
    WDR18Q9BV382MINT-7945693 MINT-7947479
    WDR33Q9C0J82MINT-7945693 MINT-7947479
    XRN2Q9H0D62MINT-7945693 MINT-7947479
    YWHAEP622582MINT-7899812 MINT-7947479
    ZNF638Q149662MINT-7945693 MINT-7947479
    C12orf4Q9NQ893I2D: score=5 
    CLUAP1Q96AJ13I2D: score=5 
    MAXP612443I2D: score=2 
    MMEP084733I2D: score=2 
    ANXA3P124293I2D: score=1 
    ARPC1BO151433I2D: score=1 
    BICD1Q96G013I2D: score=1 
    CASP7P552103I2D: score=1 
    CBX5P459733I2D: score=1 
    CNN3Q154173I2D: score=1 
    COLGALT1Q8NBJ53I2D: score=1 
    DDX3YO155233I2D: score=1 
    ESDP107683I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GRB10Q133223I2D: score=1 
    HNRNPUL1Q9BUJ23I2D: score=1 
    LARP4BQ926153I2D: score=1 
    LBRQ147393I2D: score=1 
    LEMD3Q9Y2U83I2D: score=1 
    LUC7LQ9NQ293I2D: score=1 
    NCAM2O153943I2D: score=1 
    PITPNBP487393I2D: score=1 
    PPIL1Q9Y3C63I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMB5P280743I2D: score=1 
    PXNP490233I2D: score=1 
    RAB10P610263I2D: score=1 
    RAB2AP610193I2D: score=1 
    RAB5AP203393I2D: score=1 
    RAB5CP511483I2D: score=1 
    RAB6BQ9NRW13I2D: score=1 
    RAB7AP511493I2D: score=1 
    SEC22BO753963I2D: score=1 
    SERBP1Q8NC513I2D: score=1 
    SFNP319473I2D: score=1 
    SLC2A4P146723I2D: score=1 
    STRAPQ9Y3F43I2D: score=1 
    SUN1O949013I2D: score=1 
    SUN2Q9UH993I2D: score=1 
    SYNE2Q8WXH03I2D: score=1 
    TOP2AP113883I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    ACIN1Q9UKV32MINT-7945693
    ACTA2P627362MINT-7899812
    ACTN2P356092MINT-7899812
    ACTN3Q080432MINT-7899812
    AKAP8O438232MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANKRD18AQ8IVF62MINT-7899812
    ANXA11P509952MINT-7947479
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARGLU1Q9NWB62MINT-7947479
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATP5A1P257052MINT-7899812
    ATRQ135352MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BANK1Q8NDB22MINT-7899812
    BCL7CQ8WUZ02MINT-7945693
    BIDP559572MINT-7947479
    BLMP541322MINT-7945693
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRIX1Q8TDN62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf13Q8NI282MINT-7947479
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CACNA1SQ136982MINT-7899812
    CALM1P621582MINT-7899812
    CALM2P621582MINT-7899812
    CALM3P621582MINT-7899812
    CAND1Q86VP62MINT-7945693
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CBLP226812MINT-7899812
    CCNT1O605632MINT-7945693
    CDC20Q128342MINT-7947479
    CDK12Q9NYV42MINT-7945693
    CDK3Q005262MINT-7945693
    CEP250Q9BV732MINT-7899812
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CLP1Q929892MINT-7945693
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPS3Q9UNS22MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF4O956392MINT-7945693
    CSKP412402MINT-7945693
    CTNND1O607162MINT-7947479
    CTTNQ142472MINT-7945693
    CWC15Q9P0132MINT-7947479
    DCTN1Q142032MINT-7945693
    DDB1Q165312MINT-7947479
    DDX1Q924992MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX47Q9H0S42MINT-7947479
    DDX6P261962MINT-7947479
    DESP176612MINT-7899812
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DNAJC13O751652MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DPF2Q927852MINT-7945693
    DTYMKP239192MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    EBNA1BP2Q998482MINT-7945693
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEFSECP577722MINT-7945693
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF3BP558842MINT-7947479
    EIF3EP602282MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A2Q142402MINT-7947479
    ELF2Q157232MINT-7947479
    ENSG00000096150P622692MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206289P287022MINT-7947479
    ENSG00000215077P254402MINT-7947479
    ENSG00000223367P622692MINT-7945693
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227322P287022MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000228520Q065872MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231321P287022MINT-7947479
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235307P254402MINT-7947479
    ENSG00000235650P622692MINT-7945693
    ENSG00000235712P287022MINT-7947479
    ENSG00000258947Q135092MINT-7945693
    EPB41L3Q9Y2J22MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC1Q9NV702MINT-7945693
    EXOC3O606452MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAF1Q9UNN52MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GAPDHP044062MINT-7947479
    GATAD2BQ8WXI92MINT-7945693
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNA14O958372MINT-7945693
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GSPT1P151702MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GTPBP4Q9BZE42MINT-7945693
    H1F0P073052MINT-7899812
    HAUS7Q998712MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIST1H1CP164032MINT-7899812
    HIST1H1TP224922MINT-7899812
    HIST1H2AGP0C0S82MINT-7899812
    HIST1H2AIP0C0S82MINT-7899812
    HIST1H2AKP0C0S82MINT-7899812
    HIST1H2ALP0C0S82MINT-7899812
    HIST1H2AMP0C0S82MINT-7899812
    HIST1H2BDP588762MINT-7899812
    HIST1H4AP628052MINT-7899812
    HIST1H4BP628052MINT-7899812
    HIST1H4CP628052MINT-7899812
    HIST1H4DP628052MINT-7899812
    HIST1H4EP628052MINT-7899812
    HIST1H4FP628052MINT-7899812
    HIST1H4HP628052MINT-7899812
    HIST1H4IP628052MINT-7899812
    HIST1H4JP628052MINT-7899812
    HIST1H4KP628052MINT-7899812
    HIST1H4LP628052MINT-7899812
    HIST2H4AP628052MINT-7899812
    HIST2H4BP628052MINT-7899812
    HIST4H4P628052MINT-7899812
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPRO433902MINT-7945693
    HSPA6P170662MINT-7947479
    HTATSF1O437192MINT-7945693
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO7O953732MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KIAA1279Q96EK52MINT-7945693
    KIF27Q86VH22MINT-7945693
    KMT2DO146862MINT-7945693
    KPNA1P522942MINT-7945693
    KRT17Q046952MINT-7899812
    KRT18P057832MINT-7899812
    KRT8P057872MINT-7899812
    KTI12Q96EK92MINT-7945693
    LAS1LQ9Y4W22MINT-7947479
    LDLRAP1Q5SW962MINT-7945693
    LENG9Q96B702MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC47Q8N1G42MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAGEE2Q8TD902MINT-7947479
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K4P459852MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MBD3O959832MINT-7945693
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MELKQ146802MINT-7947479
    METTL13Q8N6R02MINT-7945693
    MLKLQ8NB162MINT-7945693
    MPP2Q141682MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH11P357492MINT-7899812
    MYH13Q9UKX32MINT-7899812
    MYH2Q9UKX22MINT-7899812
    MYH3P110552MINT-7899812
    MYH7P128832MINT-7899812
    MYL12AP191052MINT-7899812
    MYL3P085902MINT-7899812
    MYLK2Q9H1R32MINT-7899812
    NAT10Q9H0A02MINT-7947479
    NCAPGQ9BPX32MINT-7945693
    NCLP193382MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NF1P213592MINT-7947479
    NFICP086512MINT-7945693
    NOLC1Q149782MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NRG1Q022972MINT-7947479
    NUDT21O438092MINT-7947479
    NUP107P577402MINT-7947479
    NUP37Q8NFH42MINT-7945693
    NUP93Q8N1F72MINT-7947479
    OLA1Q9NTK52MINT-7945693
    OTULINQ96BN82MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PARP1P098742MINT-7947479
    PARP4Q9UKK32MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCF11O949132MINT-7945693
    PCNTO956132MINT-7947479
    PDCD6IPQ8WUM42MINT-7945693
    PELOQ9BRX22MINT-7947479
    PELP1Q8IZL82MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKP3Q9Y4462MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLEQ078642MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP2R1BP301542MINT-7945693
    PRCCQ927332MINT-7947479
    PRKAG1P546192MINT-7945693
    PRPF3O433952MINT-7947479
    PRPF40AO754002MINT-7945693
    PRPF4BQ135232MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUF60Q9UHX12MINT-7945693
    PUM1Q146712MINT-7947479
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RAD21O602162MINT-7945693
    RAE1P784062MINT-7945693
    RAVER1Q8IY672MINT-7947479
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM7Q9Y5802MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    RNF2Q994962MINT-7945693
    RPL12P300502MINT-7945693
    RPL19P840982MINT-7945693
    RPL23AP627502MINT-7945693
    RPL24P837312MINT-7947479
    RPL3P390232MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS13P622772MINT-7947479
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RXRBP287022MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC23BQ154372MINT-7945693
    SEC24CP539922MINT-7947479
    SEC31BQ9NQW12MINT-7945693
    SENP3Q9H4L42MINT-7947479
    SEPT7Q161812MINT-7945693
    SF3A2Q154282MINT-7947479
    SF3B4Q154272MINT-7945693
    SHC1P293532MINT-7947479
    SHOC2Q9UQ132MINT-7945693
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA2P515312MINT-7945693
    SNAI1O958632MINT-8313510
    SNAPC4Q5SXM22MINT-7947479
    SND1Q7KZF42MINT-7945693
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPB2P085792MINT-7945693
    SNRPD1P623142MINT-7947479
    SNRPEP623042MINT-7947479
    SNUPNO951492MINT-7945693
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5L1Q9BVQ72MINT-7945693
    SPENQ96T582MINT-7947479
    SQSTM1Q135012MINT-7945693
    SREK1Q8WXA92MINT-7947479
    SRP19P091322MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF4Q081702MINT-7947479
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG1Q8WVM72MINT-7945693
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SUPV3L1Q8IYB82MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TAF9Q165942MINT-7945693
    TANC2Q9HCD62MINT-7947479
    TAOK1Q7L7X32MINT-7945693
    TGIF2LYQ8IUE02MINT-7899812
    THAP1Q9NVV92MINT-7947479
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TOX4O948422MINT-7945693
    TPM1P094932MINT-7899812
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRIM21P194742MINT-7947479
    TRIP12Q146692MINT-7945693
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TSC2P498152MINT-7899812
    TTKP339812MINT-7945693
    TTNQ8WZ422MINT-7899812
    TUBA1CQ9BQE32MINT-7947479
    TUBA3EQ6PEY22MINT-7945693
    TUBB1Q9H4B72MINT-7945693
    TUBB2AQ138852MINT-7899812
    TUBB3Q135092MINT-7945693
    TUBGCP4Q9UGJ12MINT-7947479
    TUFMP494112MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBE2SQ167632MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UMPSP111722MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP42Q9H9J42MINT-7899812
    USP48Q86UV52MINT-7945693
    VPS33AQ96AX12MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XPO6Q96QU82MINT-7945693
    XRCC6P129562MINT-7945693
    YBX3P169892MINT-7945693
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YTHDC2Q9H6S02MINT-7945693
    YWHAHQ049172MINT-7899812
    YY1P254902MINT-7945693
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF326Q5BKZ12MINT-7945693
    CASP2ENSP000003126644STRING: ENSP00000312664
    MLIPENSP000002748974STRING: ENSP00000274897
    VAV1ENSP000003022694STRING: ENSP00000302269
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    RUFY3ENSP000003703944STRING: ENSP00000370394
    SMG1ENSP000004025154STRING: ENSP00000402515
    SUMO2ENSP000004059654STRING: ENSP00000405965
    EIF6ENSP000003635594STRING: ENSP00000363559
    CELF4ENSP000003550894STRING: ENSP00000355089
    TP53BP1ENSP000003714754STRING: ENSP00000371475
    KNCNENSP000003796074STRING: ENSP00000379607
    DYNLT1ENSP000003560564STRING: ENSP00000356056
    FOXO1ENSP000003688804STRING: ENSP00000368880
    RPA2ENSP000003630214STRING: ENSP00000363021
    SIRT7ENSP000003294664STRING: ENSP00000329466
    DCLK1ENSP000002554484STRING: ENSP00000255448
    DCLK2ENSP000002965504STRING: ENSP00000296550
    KPNA3ENSP000002616674STRING: ENSP00000261667
    KPNA4ENSP000003343734STRING: ENSP00000334373
    MAPK1ENSP000002158324STRING: ENSP00000215832
    MAPK3ENSP000002630254STRING: ENSP00000263025
    KPNA5ENSP000003487044STRING: ENSP00000348704
    KPNA6ENSP000003627284STRING: ENSP00000362728
    DYNLT3ENSP000003678414STRING: ENSP00000367841
    DCXENSP000003376974STRING: ENSP00000337697
    FXNENSP000003664824STRING: ENSP00000366482
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL3ENSP000003160544STRING: ENSP00000316054
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0006997nucleus organization ----

    Find genes that share ontologies with LMNA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMNA

    Selected Novoseek inferred chemical compound relationships for LMNA gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nelfinavir 23.7 2 14600514 (1), 18344876 (1)
    rosiglitazone 18 2 14510863 (2)
    indinavir 17.1 4 14600514 (1), 16184025 (1), 12844477 (1)
    zinc 14.2 12 16278265 (1), 19494770 (1), 19323649 (1), 15998779 (1) (see all 7)
    retinoic acid 12.4 18 15219855 (3), 10694499 (3), 12844477 (2), 11478838 (1) (see all 8)
    deoxyribonucleic acid 6.22 1 12015247 (1)
    calcium 0.975 2 1467310 (1), 19144047 (1)
    cholesterol 0 4 11136544 (1), 12524233 (1), 17994215 (1), 15205219 (1)
    atp 0 6 1965140 (2), 15892163 (1), 2004657 (1)
    lipid 0 3 20130076 (2), 16181372 (1)



    Find genes that share compounds with LMNA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for LMNA gene (7 alternative transcripts): 
    NM_001257374.2  NM_001282624.1  NM_001282625.1  NM_001282626.1  NM_005572.3  NM_170707.3  NM_170708.3  

    Unigene Cluster for LMNA:

    Lamin A/C
    Hs.594444  [show with all ESTs]
    Unigene Representative Sequence: NM_170707
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000502751 ENST00000368301(uc001fnf.1) ENST00000495341 ENST00000470835
    ENST00000515711 ENST00000368300(uc001fng.2 uc001fni.2 uc009wro.1 uc001fnk.2)
    ENST00000478063 ENST00000470199 ENST00000469565 ENST00000368299 ENST00000502357
    ENST00000448611(uc010pgz.1) ENST00000515459 ENST00000368297 ENST00000504687
    ENST00000473598 ENST00000515824 ENST00000496738(uc001fnj.2 uc010pha.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA
    Clone
    Products:
         
    OriGene clones in human, mouse for LMNA (see all 18)
    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Addgene plasmids for LMNA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
      QuantiTect SYBR Green Assays in human, mouse, rat LMNA
      QuantiFast Probe-based Assays in human, mouse, rat LMNA

    Additional mRNA sequence: 

    AF381029.1 AK026584.1 AK056143.1 AK056191.1 AK057997.1 AK097801.1 AK098128.1 AK122732.1 
    AK130179.1 AK294217.1 AK295390.1 AK309539.1 AY357727.1 AY528714.1 AY847595.1 AY847596.1 
    AY847597.1 BC000511.2 BC003162.1 BC014507.1 BC018863.2 BC033088.1 M13451.1 M13452.1 
    NR_047544.1 NR_047545.1 X03444.1 X03445.1 

    Selected DOTS entries (see all 79):

    DT.100891747  DT.91871177  DT.92469899  DT.95246279  DT.100891714  DT.95294580  DT.100891710  DT.121347135 
    DT.92469913  DT.100891740  DT.100891733  DT.92057489  DT.101986435  DT.121347131  DT.121347084  DT.100891726 
    DT.99987681  DT.95322263  DT.100039687  DT.121347143  DT.121347120  DT.100891698  DT.100891751  DT.320389 

    Selected AceView cDNA sequences (see all 1597):

    CB150408 AL602697 BU528517 BU626255 BG831209 BU190818 BQ689214 BU543235 
    BM913668 CA436010 BM828139 AI654262 BQ219558 BQ215790 CD674183 BU178121 
    BM836839 BM763030 BE311540 AW245428 AU120748 BM837113 CB130594 BM785968 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LMNA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                            -                                   -                                 
    SP2:                                            -                                   -           -                     
    SP3:                                            -                                                                     
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for LMNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LMNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGGCT
    LMNA Expression
    About this image


    LMNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Primary Oocyte Primary Follicle
             Oviduct
             Secondary follicles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    LMNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMNA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594444

    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is
    prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions,
    where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and
    disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of
    ZMPSTE24/FACE1 in response to oxidative stress

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
    QuantiTect SYBR Green Assays in human, mouse, rat LMNA
    QuantiFast Probe-based Assays in human, mouse, rat LMNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LMNA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmna1 , 5 lamin A1, 5 90.15(n)1
    96.53(a)1
      3 (38.84 cM)5
    169051  NM_001002011.31  NP_001002011.21 
     884811485 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    47(a)
    many ↔ many
    10(10954013-10971823)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    67(a)
    57(a)
    1 ↔ many
    1 ↔ many
    GL344336.1(6444-21018)
    2(41214999-41216574)
    African clawed frog
    (Xenopus laevis)
    Amphibia lmna-A2 lamin A/C 76.67(n)    X06345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmna2 lamin A 76.11(n)   195815  AF397016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LamC3 nuclear envelope reassembly 37(a)
    (best of 2)
      51B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea lmn-13 Intermediate filament proteins (2
    domains)
    30(a)
    (best of 5)
      I(8771116-8773244)   --


    ENSEMBL Gene Tree for LMNA (if available)
    TreeFam Gene Tree for LMNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for LMNA gene
    DES2  NEFM2  LMNB12  VIM2  INA2  LMNB22  NEFH2  GFAP2  
    PRPH2  
    5 SIMAP similar genes for LMNA using alignment to 5 protein entries:     LMNA_HUMAN (see all proteins):
    LMNB1    LMNB2    VIM    KRT5    keratin

    Find genes that share paralogs with LMNA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for LMNA (see all 1431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583275331,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585673(+) CCACCC/G/TGCATC 11 R G C nc-transcript-variantmis10--------
    rs289289031,2,,4
    CCardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH)4 pathogenic1162585769(+) AGAACC/GCAGGG 7 P A nc-transcript-variantmis1 ese30--------
    rs289289001,2,,4
    CLipodystrophy, familial partial, 2 (FPLD2)4 pathogenic1162585778(+) GGCTGC/GGCCTT 7 R G nc-transcript-variantmis1 ese30--------
    rs577937371,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585788(+) TCGCAA/G/TCACCG 11 N S I nc-transcript-variantmis10--------
    rs289330901,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162585854(+) CGAGCG/TCGGGG 7 R L nc-transcript-variantmis10--------
    rs608642301,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 pathogenic1162601334(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs606522251,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601355(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs589126331,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601364(+) GAACTC/TCAAGG 10 S F mis10--------
    rs603102641,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601369(+) CCAAGA/GAGGCC 10 K E mis10--------
    rs289330931,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162601417(+) AGGGCA/GAGCTG 10 K E mis10--------

    HapMap Linkage Disequilibrium report for LMNA (156052364 - 156109880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMNA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    Human Gene Mutation Database (HGMD): LMNA
    Locus Specific Mutation Databases (LSDB): LMNA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMNA
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 150330   
    OMIM disorders: 181350  115200  151660  605588  613205  159001  248370  176670  275210  610140  212112  
    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
  • Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Emery-Dreifuss muscular dystrophy 3, autosomal recessive (EDMD3) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, dilated 1A (CMD1A) [MIM:115200]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lipodystrophy, familial partial, 2 (FPLD2) [MIM:151660]: A disorder characterized by the loss of
    subcutaneous adipose tissue in the lower parts of the body (limbs, buttocks, trunk). It is accompanied by an
    accumulation of adipose tissue in the face and neck causing a double chin, fat neck, or cushingoid appearance.
    Adipose tissue may also accumulate in the axillae, back, labia majora, and intraabdominal region. Affected
    patients are insulin-resistant and may develop glucose intolerance and diabetes mellitus after age 20 years,
    hypertriglyceridemia, and low levels of high density lipoprotein cholesterol. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Limb-girdle muscular dystrophy 1B (LGMD1B) [MIM:159001]: An autosomal dominant degenerative myopathy with
    age-related atrioventricular cardiac conduction disturbances, dilated cardiomyopathy, and the absence of early
    contractures. Characterized by slowly progressive skeletal muscle weakness of the hip and shoulder girdles.
    Muscle biopsy shows mild dystrophic changes. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth
    disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy,
    initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is
    classified in two main groups on the basis of electrophysiologic properties and histopathology: primary
    peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral
    axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in
    the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and
    progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hutchinson-Gilford progeria syndrome (HGPS) [MIM:176670]: Rare genetic disorder characterized by features
    reminiscent of marked premature aging. Note=The disease is caused by mutations affecting the gene represented in
    this entry. HGPS is caused by the toxic accumulation of a truncated form of lamin-A/C. This mutant protein,
    called progerin (isoform 6), acts to deregulate mitosis and DNA damage signaling, leading to premature cell death
    and senescence. The mutant form is mainly generated by a silent or missense mutation at codon 608 of prelamin A
    that causes activation of a cryptic splice donor site, resulting in production of isoform 6 with a deletion of 50
    amino acids near the C terminus. Progerin lacks the conserved ZMPSTE24/FACE1 cleavage site and therefore remains
    permanently farnesylated. Thus, although it can enter the nucleus and associate with the nuclear envelope, it
    cannot incorporate normally into the nuclear lamina (PubMed:12714972)
  • Cardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH) [MIM:212112]: A disorder
    characterized by the association of genital anomalies, hypergonadotropic hypogonadism and dilated cardiomyopathy.
    Patients can present other variable clinical manifestations including mental retardation, skeletal anomalies,
    scleroderma-like skin, graying and thinning of hair, osteoporosis. Dilated cardiomyopathy is characterized by
    ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mandibuloacral dysplasia with type A lipodystrophy (MADA) [MIM:248370]: A disorder characterized by
    mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid
    appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with loss of
    subcutaneous fat from the extremities. Adipose tissue in the face, neck and trunk is normal or increased.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lethal tight skin contracture syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by
    intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and
    epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent
    eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia,
    multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first
    week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Heart-hand syndrome Slovenian type (HHS-Slovenian) [MIM:610140]: Heart-hand syndrome (HHS) is a
    clinically and genetically heterogeneous disorder characterized by the co-occurrence of a congenital cardiac
    disease and limb malformations. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Muscular dystrophy congenital LMNA-related (MDCL) [MIM:613205]: A form of congenital muscular dystrophy.
    Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with
    joint contractures. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in LMNA may cause a late-onset cardiocutaneous progeria syndrome characterized by cutaneous
    manifestations of aging appearing in the third decade of life, cardiac valve calcification and dysfunction,
    prominent atherosclerosis, and cardiomyopathy, leading to death on average in the fourth decade

  • Selected diseases for LMNA (see all 51):    
    About MalaCards
    laminopathy type decaudain-vigouroux    lmna-related cardiocutaneous progeria syndrome    lipodystrophy, familial partial, type 2    progeria-associated arthropathy
    familial partial lipodystrophy, kobberling type    cardiomyopathy, dilated, 1a    lmna-related emery-dreifuss muscular dystrophy, autosomal    dilated cardiomyopathy with quadriceps myopathy
    progeria    emery-dreifuss muscular dystrophy    autosomal codominant severe lipodystrophic laminopathy    atypical werner syndrome
    charcot-marie-tooth neuropathy type 2b1    congenital muscular dystrophy    lmna-related muscle diseases    mandibuloacral dysplasia
    familial partial lipodystrophy    charcot-marie-tooth disease type 2b1    mandibuloacral dysplasia with type a lipodystrophy    emery-dreifuss muscular dystrophy 2, ad

    9 diseases from the University of Copenhagen DISEASES database for LMNA:
    Progeria     Lipodystrophy     Dilated cardiomyopathy     Myopathy
    Neuropathy     Congenital heart block     Werner syndrome     Acanthosis nigricans
    Genetic disorder

    Find genes that share disorders with LMNA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LMNA gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, familial partial 97.8 88 12015247 (3), 11397881 (2), 18364375 (2), 19622949 (2) (see all 63)
    progeria 97 77 15479179 (2), 17076270 (2), 16671095 (2), 17469202 (2) (see all 59)
    muscular dystrophy emery-dreifuss 96.5 48 19589462 (2), 16697197 (2), 12685553 (1), 20225280 (1) (see all 41)
    emery-dreifuss muscular dystrophy, autosomal dominant 96.4 21 11532159 (1), 10587585 (1), 11102973 (1), 15639119 (1) (see all 19)
    lgmd1b 95.4 28 10814726 (4), 15678000 (3), 19070492 (2), 15668447 (1) (see all 15)
    mandibuloacral dysplasia 95.3 25 16278265 (2), 16046620 (1), 16364671 (1), 15843404 (1) (see all 16)
    partial lipodystrophy 93.2 32 15817509 (1), 11102973 (1), 12524233 (1), 15773753 (1) (see all 26)
    lipodystrophy 90 59 18077842 (3), 11078466 (2), 12788894 (2), 12844477 (2) (see all 37)
    acroosteolysis 86.4 4 16278265 (1), 17848409 (1), 18554282 (1)
    lipodystrophy, congenital generalized 85.4 4 19169477 (1), 19494770 (1), 14516935 (1)

    GeneTests: LMNA
    GeneReviews: LMNA
    Genetic Association Database (GAD): LMNA
    Human Genome Epidemiology (HuGE) Navigator: LMNA (37 documents)

    Export disorders for LMNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMNA gene, integrated from 10 sources (see all 818):
    (articles sorted by number of sources associating them with LMNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. (PubMed id 12920062)1, 2, 4, 9 Sebillon P.... Komajda M. (J. Med. Genet. 2003)
    2. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. (PubMed id 15219508)1, 2, 4, 9 Hermida-Prieto M....Crespo-Leiro M. (Am. J. Cardiol. 2004)
    3. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). (PubMed id 12768443)1, 2, 9 Cao H. and Hegele R.A. (J. Hum. Genet. 2003)
    4. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. (PubMed id 17327460)1, 4, 9 Owen K.R....McCarthy M.I. (Diabetes 2007)
    5. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (PubMed id 18585512)1, 4, 9 Parks S.B....Hershberger R.E. (Am. Heart J. 2008)
    6. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. (PubMed id 11897440)1, 2, 9 Arbustini E.... Tavazzi L. (J. Am. Coll. Cardiol. 2002)
    7. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. (PubMed id 17327461)1, 4, 9 Mesa J.L....Barroso I. (Diabetes 2007)
    8. Variation in the lamin A/C gene: associations with metabolic syndrome. (PubMed id 15205219)1, 4, 9 Steinle N.I....Shuldiner A.R. (Arterioscler. Thromb. Vasc. Biol. 2004)
    9. LMNA mutations in atypical Werner's syndrome. (PubMed id 12927431)1, 2, 9 Chen L.... Oshima J. (Lancet 2003)
    10. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. (PubMed id 12628721)1, 2, 9 Taylor M.R.G.... Mestroni L. (J. Am. Coll. Cardiol. 2003)

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