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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMNA Gene

protein-coding   GIFtS: 71
GCID: GC01P156053

lamin A/C

(Previous names: cardiomyopathy, dilated 1A (autosomal dominant), limb girdle...)
(Previous symbols: LMN1, CMD1A, LGMD1B, PRO1, LMNL1)
 Explore 126 diseases affiliated with
LMNA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LMNA    

Aliases
for LMNA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lamin A/C1 2     70 KDa Lamin2
LMN11 2 3 5     CDCD12
CMD1A1 2 5     CDDC2
HGPS1 2 5     CMT2B12
LGMD1B1 2 5     FPL2
LMNL11 2     FPLD22
PRO11 2     IDC2
Lamin A/C-Like 11 2     LDP12
EMD22 5     LFP2
FPLD2 5     LMNC2
Cardiomyopathy, Dilated 1A (Autosomal Dominant)1     Lamin1
Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant)1     Prelamin-A/C1
Progeria 1 (Hutchinson-Gilford Type)1     Renal Carcinoma Antigen NY-REN-322

External Ids:    HGNC: 66361   Entrez Gene: 40002   Ensembl: ENSG000001607897   OMIM: 1503305   UniProtKB: P025453   

Export aliases for LMNA gene to outside databases

Previous GC identifers: GC01P153921 GC01P151817 GC01P152830 GC01P153301 GC01P152897 GC01P154318 GC01P127446


Summaries
for LMNA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LMNA:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The
lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix
is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in
nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B.
Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases:
Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated
cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear
membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin
A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin
organization, nuclear membrane and telomere dynamics
Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage
in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence

Gene Wiki entry for LMNA


Genomic Views
for LMNA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMNA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LMNA promoter sequence
   Search SABiosciences Chromatin IP Primers for LMNA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

LMNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156053:  view genomic region     (about GC identifiers)

Start:
 156,052,364 bp from pter      End:
 156,109,880 bp from pter
Size:
 57,517 bases      Orientation:
 plus strand

Proteins
for LMNA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545 (See protein sequence)
Recommended Name: Prelamin-A/C precursor  
Size: 664 amino acids; 74139 Da
Subunit: Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and
with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43 (By similarity). Proteolytically processed isoform A
interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP; may regulate MLIP
localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability
Subcellular location: Nucleus. Nucleus envelope. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope
targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can
then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C
Miscellaneous: There are three types of lamins in human cells: A, B, and C
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Sequence caution: Sequence=CAA27173.1; Type=Frameshift; Positions=582;
6/8 PDB 3D structures from and Proteopedia for LMNA (see all 8):
1IFR (3D)        1IVT (3D)        1X8Y (3D)        2XV5 (3D)        3GEF (3D)        3V4Q (3D)    
Secondary accessions: B4DI32 D3DVB0 E7EUI9 P02546 Q5TCJ2 Q5TCJ3 Q969I8 Q96JA2
Alternative splicing: 4 isoforms:  P02545-1   P02545-2   P02545-3   P02545-4   (No experimental confirmation available. Ref.3 (BAG58344) sequence is in conflict in position: 556:G->R)

Explore the universe of human proteins at neXtProt for LMNA: NX_P02545

Post-translational modifications:

  • Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating
    • lamin associations1
  • Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The
    • prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the last
    three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15 C-terminal amino
    acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these blocks cleavage1
  • Sumoylation is necessary for the localization to the nuclear envelope1
  • Farnesylation of prelamin-A/C facilitates nuclear envelope targeting1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02545

    • LMNA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001244303.1  NP_005563.1  NP_733821.1  NP_733822.1  

    ENSEMBL proteins: 
     ENSP00000357284   ENSP00000357283   ENSP00000357282   ENSP00000395597   ENSP00000424518  
     ENSP00000357280   ENSP00000426535   ENSP00000421821   ENSP00000424977   ENSP00000292304  
     ENSP00000355292   ENSP00000376164  
    Reactome Protein details: P02545
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): LMNA
    OriGene Protein Over-expression Lysate (see all 2): LMNA
    OriGene Custom Protein Services for LMNA 
    GenScript Custom Purified and Recombinant Proteins Services for LMNA
    Novus Biologicals LMNA Protein
    Novus Biologicals LMNA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for LMNA
    Uscn Proteins for LMNA

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005626insoluble fraction ----
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS--
    GO:0005638lamin filament TAS10080180
    GO:0005652nuclear lamina TAS8344919


    LMNA for ontologies           About GeneDecksing



    LMNA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNA  (lamin A/C)
    OriGene Antibodies (see all 5): LMNA
    OriGene Custom Antibody Services for LMNA 
    GenScript Superior Antibodies for LMNA
    Novus Biologicals LMNA Antibodies
    Abcam antibodies for LMNA 
    Uscn Antibodies for LMNA
    ThermoFisher Antibody for LMNA

    Assay Products for LMNA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMNA
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LMNA

    Protein Domains /
    Families
    for LMNA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LMNA for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry P02545

    ProtoNet protein and cluster: P02545

    2 Blocks protein families:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Similarity: Belongs to the intermediate filament family


    Function
    for LMNA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear
    membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin
    A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin
    organization, nuclear membrane and telomere dynamics
    Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage
    in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence

         Genatlas biochemistry entry for LMNA:
    lamin,types A and C,common gene,alternatively spliced isoforms

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): LMNA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMNA
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: LMNA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMNA (see all 7)
    OriGene shRNA RFP: LMNA
    OriGene siRNA: LMNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMNA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LMNA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LMNA (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LMNA (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LMNA
    Search LifeMap BioReagents cell lines for LMNA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS8344919
    GO:0005515protein binding IPI10727209


    LMNA for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for LMNA:
     Increased S DNA content  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for LMNA: Lmnatm6Lgf Lmnatm1Stw Lmnatm4Lgf Lmnatm5Lgf Lmnatm1Lgf Lmnatm2Lgf
         15/25 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Lmna) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    LMNA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LMNA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and survival_Caspase cascade
    		Apoptosis and survival_Caspase cascade1.00
    		Apoptosis and survival FAS signaling cascades0.44
    		Apoptosis and survival Caspase cascade1.00
    		Caspase cascade in apoptosis0.42
    		Apoptosis and survival_FAS signaling cascades0.44
    		FAS pathway and Stress induction of HSP regulation0.33
    2Clearance of Nuclear Envelope Membranes from Chromatin
    		Clearance of Nuclear Envelope Membranes from Chromatin1.00
    		Nuclear Envelope Breakdown0.56
    		Initiation of Nuclear Envelope Reformation0.69
    		Mitotic Prophase0.26
    		Nuclear Envelope Reassembly0.69
    3M Phase
    		M Phase1.00
    		Mitotic Metaphase and Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Mitotic Anaphase0.85
    4Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Meiosis0.70
    		Telomere clustering at the nuclear membrane0.82
    		Chromosome Maintenance0.56
    5Activation of Chaperone Genes by XBP1(S)
    		Activation of Chaperone Genes by XBP1(S)1.00
    		Unfolded Protein Response0.71
    		Activation of Chaperones by IRE1alpha0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LMNA
        Caspase Cascade
    Granzyme Pathway
    Fas Signaling

    3 Cell Signaling Technology (CST) Pathways for LMNA
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for LMNA 
        FAS pathway and Stress induction of HSP regulation
    Adipogenesis
    Arrhythmogenic right ventricular cardiomyopathy
    Caspase cascade in apoptosis

    5/24        Reactome Pathways for LMNA (see all 24)
        Initiation of Nuclear Envelope Reformation
    Clearance of Nuclear Envelope Membranes from Chromatin
    Cell Cycle
    M Phase
    Apoptosis

    1 PharmGKB Pathway for LMNA
        Antiarrhythmic Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for LMNA):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy


    LMNA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LMNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    921 Interacting proteins for LMNA (P025451, 2, 3 ENSP000003572834) via UniProtKB, MINT, STRING, and/or I2D (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI32, 3, ENSP000003854794MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI32, 3MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    HIST2H3DQ71DI32, 3MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=2 STRING: ENSP00000349960
    H2AFXP161042, 3, ENSP000003643104MINT-8361862 MINT-7899812 I2D: score=2 STRING: ENSP00000364310
    MYH9P355792, 3MINT-7945693 MINT-7899812 MINT-7947479 I2D: score=1 
    NUP153P497902, 3, ENSP000002620774MINT-7945693 MINT-7893777 I2D: score=1 STRING: ENSP00000262077
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    UCHL5Q9Y5K52, 3, ENSP000003564254MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356425
    KPNA2P522922, 3MINT-7945693 MINT-7947479 I2D: score=5 
    EXOC5O004712, 3MINT-7945693 MINT-7947479 I2D: score=4 
    PCBP1Q153652, 3, ENSP000003055564MINT-7947479 I2D: score=2 STRING: ENSP00000305556
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    EFTUD2Q150292, 3MINT-7945693 MINT-7947479 I2D: score=1 
    EIF3IQ133472, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HSP90B1P146252, 3MINT-7945693 MINT-7947479 I2D: score=1 
    RBBP4Q090282, 3, ENSP000003625924MINT-7947479 I2D: score=1 STRING: ENSP00000362592
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    TRIM28Q132632, 3MINT-7945693 MINT-7947479 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    CDK1P064932, 3MINT-7945693 I2D: score=2 
    ACTG1P632612, 3MINT-7899812 I2D: score=1 
    HIST1H1DP164022, 3MINT-7899812 I2D: score=1 
    IKQ131232, 3MINT-7945693 I2D: score=1 
    MORF4L2Q150142, 3MINT-7945693 I2D: score=1 
    RBM10P981752, 3MINT-7945693 I2D: score=1 
    SRSF2Q011302, 3MINT-7945693 I2D: score=1 
    TNPO1Q929732, 3MINT-7947479 I2D: score=1 
    YWHAGP619812, 3MINT-7899812 I2D: score=1 
    MORF4L1Q9UBU82, 3, ENSP000003313104MINT-7945693 MINT-8361862 MINT-8329389 MINT-8329289 I2D: score=1 STRING: ENSP00000331310
    TMPOP421662, 3, ENSP000002667324MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000266732
    PASKQ96RG22, 3, ENSP000002340404MINT-8148942 MINT-8148953 I2D: score=1 STRING: ENSP00000234040
    YWHAZP631042, 3, ENSP000003095034MINT-3297814 MINT-7899812 I2D: score=1 STRING: ENSP00000309503
    SUMO1P631652, 3, ENSP000003760764MINT-7947479 I2D: score=1 STRING: ENSP00000376076
    AIMP2Q131552, 3, ENSP000002230294MINT-8145495 I2D: score=1 STRING: ENSP00000223029
    ALOX12P180541, 3, ENSP000002515354EBI-351935,EBI-1633210 I2D: score=4 STRING: ENSP00000251535
    SMAD3P840222, 3, ENSP000003329734MINT-51248 I2D: score=3 STRING: ENSP00000332973
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    BRCA1P383982MINT-8361862 MINT-8329389 MINT-8329289
    BRCA2P515872MINT-8361862 MINT-8329389 MINT-8329289
    HNRNPA2B1P226262MINT-7945693 MINT-7899812 MINT-7947479
    HNRNPCP079102MINT-7945693 MINT-7899812 MINT-7947479
    PALB2Q86YC22MINT-8361862 MINT-8329389 MINT-8329289
    PRKDCP785272, ENSP000003134204MINT-7945693 MINT-7947479 STRING: ENSP00000313420
    RAD51Q066092MINT-8361862 MINT-8329389 MINT-8329289
    RALYQ9UKM92MINT-7945693 MINT-7899812 MINT-7947479
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    VIMP086702MINT-7945693 MINT-7899812 MINT-7947479
    TOR1AIP1Q5JTV83, ENSP000002715834I2D: score=4 STRING: ENSP00000271583
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    ALOX12BO753423, ENSP000003151674I2D: score=2 STRING: ENSP00000315167
    FOSP011003, ENSP000003062454I2D: score=2 STRING: ENSP00000306245
    PCGF2P352273, ENSP000003540334I2D: score=2 STRING: ENSP00000354033
    BANF1O755313, ENSP000003102754I2D: score=1 STRING: ENSP00000310275
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    ING1Q9UK533, ENSP000003649294I2D: score=1 STRING: ENSP00000364929
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    STACQ994693, ENSP000002731834I2D: score=1 STRING: ENSP00000273183
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    UNC13DQ70J993, ENSP000002075494I2D: score=1 STRING: ENSP00000207549
    EMDP504023, ENSP000003588574I2D: score=4 STRING: ENSP00000358857
    LMNB1P207003, ENSP000002613664I2D: score=7 STRING: ENSP00000261366
    PRKCAP172523, ENSP000002843844I2D: score=3 STRING: ENSP00000284384
    RB1P064003, ENSP000002671634I2D: score=4 STRING: ENSP00000267163
    SYNE1Q8NF913, ENSP000002653684I2D: score=2 STRING: ENSP00000265368
    LMNB2Q032523, ENSP000003270544I2D: score=1 STRING: ENSP00000327054
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CASP1P294663, ENSP000004100764I2D: score=2 STRING: ENSP00000410076
    CASP6P552123, ENSP000002651644I2D: score=1 STRING: ENSP00000265164
    NARFQ9UHQ13, ENSP000003098994I2D: score=2 STRING: ENSP00000309899
    SREBF1P369563, ENSP000003480694I2D: score=3 STRING: ENSP00000348069
    TOR1AO146563, ENSP000003457194I2D: score=1 STRING: ENSP00000345719
    URB2Q141463, ENSP000002582434I2D: score=3 STRING: ENSP00000258243
    ZNF239Q166003, ENSP000003077744I2D: score=2 STRING: ENSP00000307774
    CTCFP497113, ENSP000002640104I2D: score=1 STRING: ENSP00000264010
    EGFP011333, ENSP000002651714I2D: score=2 STRING: ENSP00000265171
    FLNAP213333, ENSP000003588664I2D: score=1 STRING: ENSP00000358866
    BNIP3LO602383, ENSP000003700034I2D: score=1 STRING: ENSP00000370003
    MRPS26Q9BYN83, ENSP000003696824I2D: score=1 STRING: ENSP00000369682
    CDH1P128303, ENSP000002617694I2D: score=2 STRING: ENSP00000261769
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    FYCO1Q9BQS83, ENSP000002961374I2D: score=3 STRING: ENSP00000296137
    MRGBPQ9NV563, ENSP000003595184I2D: score=1 STRING: ENSP00000359518
    MYCP011063, ENSP000003672074I2D: score=4 STRING: ENSP00000367207
    KAT5Q929933, ENSP000003403304I2D: score=5 STRING: ENSP00000340330
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    ACTL6AO960192MINT-7945693 MINT-7947479
    ACTR1AP611632MINT-7945693 MINT-7947479
    ACTR2P611602MINT-7945693 MINT-7947479
    ADNPQ9H2P02MINT-7945693 MINT-7947479
    AHNAKQ096662MINT-7945693 MINT-7947479
    ANAPC1Q9H1A42MINT-7945693 MINT-7947479
    ANLNQ9NQW62MINT-7945693 MINT-7947479
    AP1B1Q105672MINT-7945693 MINT-7947479
    ARCN1P484442MINT-7945693 MINT-7947479
    ARHGEF1Q928882MINT-7945693 MINT-7947479
    ARHGEF2Q929742MINT-7945693 MINT-7947479
    ARID1AO144972MINT-7945693 MINT-7947479
    AURKBQ96GD42MINT-7945693 MINT-7947479
    BAZ1AQ9NRL22MINT-7945693 MINT-7947479
    BCAS2O759342MINT-7945693 MINT-7947479
    BCLAF1Q9NYF82MINT-7945693 MINT-7947479
    BRD8Q9H0E92MINT-7945693 MINT-7947479
    BTAF1O149812MINT-7945693 MINT-7947479
    BUB1O436832MINT-7945693 MINT-7947479
    BUB1BO605662MINT-7945693 MINT-7947479
    BUB3O436842MINT-7945693 MINT-7947479
    BZW1Q7L1Q62MINT-7945693 MINT-7947479
    C22orf28Q9Y3I02MINT-7945693 MINT-7947479
    CAPGP401212MINT-7945693 MINT-7947479
    CAPZA1P529072MINT-7945693 MINT-7947479
    CCNB1P146352MINT-7945693 MINT-7947479
    CCT2P783712MINT-7945693 MINT-7947479
    CCT3P493682MINT-7945693 MINT-7947479
    CCT4P509912MINT-7945693 MINT-7947479
    CCT5P486432MINT-7945693 MINT-7947479
    CCT6AP402272MINT-7945693 MINT-7947479
    CCT7Q998322MINT-7945693 MINT-7947479
    CCT8P509902MINT-7945693 MINT-7947479
    CDC16Q130422MINT-7945693 MINT-7947479
    CDC23Q9UJX22MINT-7945693 MINT-7947479
    CDC27P302602MINT-7945693 MINT-7947479
    CDC73Q6P1J92MINT-7945693 MINT-7947479
    CDK9P507502MINT-7945693 MINT-7947479
    CDKN2AIPQ9NXV62MINT-7945693 MINT-7947479
    CHD1LQ86WJ12MINT-7945693 MINT-7947479
    CHD8Q9HCK82MINT-7945693 MINT-7947479
    CHEK1O147572MINT-7945693 MINT-7947479
    CKAP5Q140082MINT-7945693 MINT-7947479
    COPAP536212MINT-7945693 MINT-7947479
    COPB1P536182MINT-7945693 MINT-7947479
    COPB2P356062MINT-7945693 MINT-7947479
    COPG1Q9Y6782MINT-7945693 MINT-7947479
    COPG2Q9UBF22MINT-7945693 MINT-7947479
    COPS5Q929052MINT-7945693 MINT-7947479
    CPSF2Q9P2I02MINT-7945693 MINT-7947479
    CPSF3Q9UKF62MINT-7945693 MINT-7947479
    CPSF7Q8N6842MINT-7945693 MINT-7947479
    CSE1LP550602MINT-7945693 MINT-7947479
    CSTF3Q129962MINT-7945693 MINT-7947479
    CUL1Q136162MINT-7945693 MINT-7947479
    DCTN2Q135612MINT-7945693 MINT-7947479
    DDX17Q928412MINT-7945693 MINT-7947479
    DDX19AQ9NUU72MINT-7945693 MINT-7947479
    DDX19BQ9UMR22MINT-7945693 MINT-7947479
    DDX39AO001482MINT-7945693 MINT-7947479
    DDX3XO005712MINT-7945693 MINT-7947479
    DDX41Q9UJV92MINT-7945693 MINT-7947479
    DDX42Q86XP32MINT-7945693 MINT-7947479
    DDX5P178442MINT-7945693 MINT-7947479
    DEPDC7Q96QD52MINT-7945693 MINT-7947479
    DFNA5O604432MINT-7945693 MINT-7947479
    DIAPH1O606102MINT-7945693 MINT-7947479
    DIDO1Q9BTC02MINT-7945693 MINT-7947479
    DMAP1Q9NPF52MINT-7945693 MINT-7947479
    DNAJA1P316892MINT-7945693 MINT-7947479
    DNM1LO004292MINT-7945693 MINT-7947479
    DNM2P505702MINT-7945693 MINT-7947479
    DRG1Q9Y2952MINT-7945693 MINT-7947479
    DSPP159242MINT-7945693 MINT-7947479
    DYNC1H1Q142042MINT-7945693 MINT-7947479
    DYNC1LI2O432372MINT-7945693 MINT-7947479
    EEF1A1P681042MINT-7945693 MINT-7947479
    EHD1Q9H4M92MINT-7945693 MINT-7947479
    EHD4Q9H2232MINT-7945693 MINT-7947479
    EIF2S3P410912MINT-7945693 MINT-7947479
    EIF3GO758212MINT-7945693 MINT-7947479
    EIF4A1P608422MINT-7945693 MINT-7947479
    EIF4A3P389192MINT-7945693 MINT-7947479
    EIF4G2P783442MINT-7945693 MINT-7947479
    EIF5BO608412MINT-7945693 MINT-7947479
    ELAVL1Q157172MINT-7945693 MINT-7947479
    ENAHQ8N8S72MINT-7945693 MINT-7947479
    ENSG00000266714Q96JP22MINT-7945693 MINT-7947479
    EPPK1P581072MINT-7945693 MINT-7947479
    EPS8L2Q9H6S32MINT-7945693 MINT-7947479
    ETF1P624952MINT-7945693 MINT-7947479
    ETV6P412122MINT-7945693 MINT-7947479
    EXOC2Q96KP12MINT-7945693 MINT-7947479
    EXOC4Q96A652MINT-7945693 MINT-7947479
    EXOC7Q9UPT52MINT-7945693 MINT-7947479
    EXOSC10Q017802MINT-7945693 MINT-7947479
    FAM129BQ96TA12MINT-7945693 MINT-7947479
    FANCIQ9NVI12MINT-7945693 MINT-7947479
    FASNP493272MINT-7945693 MINT-7947479
    FEN1P397482MINT-7945693 MINT-7947479
    FERMT1Q9BQL62MINT-7945693 MINT-7947479
    FHOD1Q9Y6132MINT-7945693 MINT-7947479
    FUSP356372MINT-7945693 MINT-7947479
    GATAD2AQ86YP42MINT-7945693 MINT-7947479
    GCN1L1Q926162MINT-7945693 MINT-7947479
    GEMIN4P576782MINT-7945693 MINT-7947479
    GTF2IP783472MINT-7945693 MINT-7947479
    GTF3C2Q8WUA42MINT-7945693 MINT-7947479
    GULP1Q9UBP92MINT-7945693 MINT-7947479
    HBS1LQ9Y4502MINT-7945693 MINT-7947479
    HDAC1Q135472MINT-7945693 MINT-7947479
    HDAC2Q927692MINT-7945693 MINT-7947479
    HDLBPQ003412MINT-7945693 MINT-7947479
    HELLSQ9NRZ92MINT-7945693 MINT-7947479
    HIP1RO751462MINT-7945693 MINT-7947479
    HIRAP541982MINT-7945693 MINT-7947479
    HLTFQ145272MINT-7945693 MINT-7947479
    HNRNPFP525972MINT-7945693 MINT-7947479
    HNRNPH1P319432MINT-7945693 MINT-7947479
    HNRNPKP619782MINT-7945693 MINT-7947479
    HNRNPMP522722MINT-7945693 MINT-7947479
    HNRNPUQ008392MINT-7945693 MINT-7947479
    HSP90AA1P079002MINT-7945693 MINT-7947479
    HSP90AB1P082382MINT-7945693 MINT-7947479
    HSPA12AO433012MINT-7945693 MINT-7947479
    HSPA5P110212MINT-7945693 MINT-7947479
    HSPA8P111422MINT-7945693 MINT-7947479
    HSPB1P047922MINT-7945693 MINT-7947479
    HSPD1P108092MINT-7945693 MINT-7947479
    ILF2Q129052MINT-7945693 MINT-7947479
    INTS1Q8N2012MINT-7945693 MINT-7947479
    INTS3Q68E012MINT-7945693 MINT-7947479
    IPO5O004102MINT-7945693 MINT-7947479
    IPO9Q96P702MINT-7945693 MINT-7947479
    IQGAP1P469402MINT-7945693 MINT-7947479
    KDM1AO603412MINT-7945693 MINT-7947479
    KHDRBS1Q076662MINT-7945693 MINT-7947479
    KIF11P527322MINT-7945693 MINT-7947479
    KIF21AQ7Z4S62MINT-7945693 MINT-7947479
    KIF2CQ996612MINT-7945693 MINT-7947479
    KIF4AO952392MINT-7945693 MINT-7947479
    KPNB1Q149742MINT-7945693 MINT-7947479
    LATS2Q9NRM72, ENSP000003720354MINT-8313510 STRING: ENSP00000372035
    LIMS1P480592MINT-7945693 MINT-7947479
    LRRC40Q9H9A62MINT-7945693 MINT-7947479
    LRWD1Q9UFC02MINT-7945693 MINT-7947479
    MAD1L1Q9Y6D92MINT-7945693 MINT-7947479
    MAP2K7O147332MINT-7945693 MINT-7947479
    MATR3P432432MINT-7945693 MINT-7947479
    MDN1Q9NU222MINT-7945693 MINT-7947479
    MED4Q9NPJ62MINT-7945693 MINT-7947479
    MRE11AP499592MINT-7945693 MINT-7947479
    MSH2P432462MINT-7945693 MINT-7947479
    MSH6P527012MINT-7945693 MINT-7947479
    MTA2O947762MINT-7945693 MINT-7947479
    MVPQ147642MINT-7945693 MINT-7947479
    MYO15BQ96JP22MINT-7945693 MINT-7947479
    NACC1Q96RE72MINT-7945693 MINT-7947479
    NBNO609342MINT-7945693 MINT-7947479
    NCAPD2Q150212MINT-7945693 MINT-7947479
    NCAPHQ150032MINT-7945693 MINT-7947479
    NCOR1O753762MINT-7945693 MINT-7947479
    NDC80O147772MINT-7945693 MINT-7947479
    NELFBQ8WX922MINT-7945693 MINT-7947479
    NIPBLQ6KC792MINT-7945693 MINT-7947479
    NONOQ152332MINT-7945693 MINT-7947479
    NPM1P067482MINT-7899812 MINT-7947479
    NSFP464592MINT-7945693 MINT-7947479
    NSUN5Q96P112MINT-7945693 MINT-7947479
    NUDCQ9Y2662MINT-7945693 MINT-7947479
    NUF2Q9BZD42MINT-7945693 MINT-7947479
    NUP155O756942MINT-7945693 MINT-7947479
    ORC2Q134162MINT-7945693 MINT-7947479
    ORC3Q9UBD52MINT-7945693 MINT-7947479
    OXSR1O957472MINT-7945693 MINT-7947479
    PAK4O960132MINT-7945693 MINT-7947479
    PARVAQ9NVD72MINT-7945693 MINT-7947479
    PARVBQ9HBI12MINT-7945693 MINT-7947479
    PCBP2Q153662MINT-7945693 MINT-7947479
    PDLIM7Q9NR122MINT-7945693 MINT-7947479
    PFKMP082372MINT-7945693 MINT-7947479
    PFKPQ018132MINT-7945693 MINT-7947479
    PHGDHO431752MINT-7945693 MINT-7947479
    PICALMQ134922MINT-7945693 MINT-7947479
    PKN2Q165132MINT-7945693 MINT-7947479
    PLECQ151492MINT-7945693 MINT-7947479
    PLK1P533502MINT-7945693 MINT-7947479
    PLRG1O436602MINT-7945693 MINT-7947479
    PNNQ9H3072MINT-7945693 MINT-7947479
    POLD1P283402MINT-7945693 MINT-7947479
    POLR1CO151602MINT-7945693 MINT-7947479
    PPP1CAP621362MINT-7945693 MINT-7947479
    PPP2R1AP301532MINT-7945693 MINT-7947479
    PRPF19Q9UMS42MINT-7945693 MINT-7947479
    PRPF6O949062MINT-7945693 MINT-7947479
    PRPF8Q6P2Q92MINT-7945693 MINT-7947479
    PSMC1P621912MINT-7945693 MINT-7947479
    PSMC2P359982MINT-7945693 MINT-7947479
    PSMC3P179802MINT-7945693 MINT-7947479
    PSMC4P436862MINT-7945693 MINT-7947479
    PSMC5P621952MINT-7945693 MINT-7947479
    PSMC6P623332MINT-7945693 MINT-7947479
    PSMD1Q994602MINT-7945693 MINT-7947479
    PSMD11O002312MINT-7945693 MINT-7947479
    PSMD12O002322MINT-7945693 MINT-7947479
    PSMD13Q9UNM62MINT-7945693 MINT-7947479
    PSMD2Q132002MINT-7945693 MINT-7947479
    PSMD3O432422MINT-7945693 MINT-7947479
    PTBP1P265992MINT-7945693 MINT-7947479
    RACGAP1Q9H0H52MINT-7945693 MINT-7947479
    RAD18Q9NS912MINT-7945693 MINT-7947479
    RAD50Q928782MINT-7945693 MINT-7947479
    RANBP2P497922MINT-7945693 MINT-7947479
    RANGAP1P460602MINT-7945693 MINT-7947479
    RBBP5Q152912MINT-7945693 MINT-7947479
    RBBP7Q165762MINT-7945693 MINT-7947479
    RBM17Q96I252MINT-7945693 MINT-7947479
    RBM39Q144982MINT-7945693 MINT-7947479
    RBM4Q9BWF32MINT-7945693 MINT-7947479
    RBM45Q8IUH32MINT-7945693 MINT-7947479
    RBMXP381592MINT-7945693 MINT-7947479
    RCOR1Q9UKL02MINT-7945693 MINT-7947479
    RFC2P352502MINT-7945693 MINT-7947479
    RFC3P409382MINT-7945693 MINT-7947479
    RFC4P352492MINT-7945693 MINT-7947479
    RFC5P409372MINT-7945693 MINT-7947479
    RIF1Q5UIP02MINT-7945693 MINT-7947479
    ROCK2O751162MINT-7945693 MINT-7947479
    RPL13P263732MINT-7945693 MINT-7947479
    RPL22P352682MINT-7945693 MINT-7947479
    RPL31P628992MINT-7945693 MINT-7947479
    RPLP0P053882MINT-7945693 MINT-7947479
    RPS3P233962MINT-7945693 MINT-7899812
    RPS6KA4O756762MINT-7945693 MINT-7947479
    RPS6KB2Q9UBS02MINT-7945693 MINT-7947479
    RUVBL1Q9Y2652MINT-7945693 MINT-7947479
    RUVBL2Q9Y2302MINT-7945693 MINT-7947479
    SART1O432902MINT-7945693 MINT-7947479
    SCYL2Q6P3W72MINT-7945693 MINT-7947479
    SEH1LQ96EE32MINT-7945693 MINT-7947479
    SEPT9Q9UHD82MINT-7945693 MINT-7947479
    SETXQ7Z3332MINT-7945693 MINT-7947479
    SF3A1Q154592MINT-7945693 MINT-7947479
    SF3A3Q128742MINT-7945693 MINT-7947479
    SF3B1O755332MINT-7945693 MINT-7947479
    SF3B14Q9Y3B42MINT-7945693 MINT-7947479
    SF3B2Q134352MINT-7945693 MINT-7947479
    SF3B3Q153932MINT-7945693 MINT-7947479
    SFPQP232462MINT-7945693 MINT-7947479
    SHROOM3Q8TF722MINT-7945693 MINT-7947479
    SMARCA5O602642MINT-7945693 MINT-7947479
    SMARCAD1Q9H4L72MINT-7945693 MINT-7947479
    SMARCB1Q128242MINT-7945693 MINT-7947479
    SMARCC1Q929222MINT-7945693 MINT-7947479
    SMARCC2Q8TAQ22MINT-7945693 MINT-7947479
    SMARCD1Q96GM52MINT-7945693 MINT-7947479
    SMARCE1Q969G32MINT-7945693 MINT-7947479
    SMC1AQ146832MINT-7945693 MINT-7947479
    SMC2O953472MINT-7945693 MINT-7947479
    SMC3Q9UQE72MINT-7945693 MINT-7947479
    SMC4Q9NTJ32MINT-7945693 MINT-7947479
    SMCHD1A6NHR92MINT-7945693 MINT-7947479
    SMN1Q166372MINT-7945693 MINT-7947479
    SMN2Q166372MINT-7945693 MINT-7947479
    SNRNP200O756432MINT-7945693 MINT-7947479
    SNRNP40Q96DI72MINT-7945693 MINT-7947479
    SNRNP70P086212MINT-7945693 MINT-7947479
    SNRPD3P623182MINT-7945693 MINT-7947479
    SPATA5Q8NB902MINT-7945693 MINT-7947479
    SPTAN1Q138132MINT-7945693 MINT-7947479
    SPTBN1Q010822MINT-7945693 MINT-7947479
    SRP54P610112MINT-7945693 MINT-7947479
    SRP68Q9UHB92MINT-7945693 MINT-7947479
    SRP72O760942MINT-7945693 MINT-7947479
    SRSF1Q079552MINT-7945693 MINT-7947479
    SRSF7Q166292MINT-7945693 MINT-7947479
    SUGT1Q9Y2Z02MINT-7945693 MINT-7947479
    SYMPKQ927972MINT-7945693 MINT-7947479
    TARDBPQ131482MINT-7945693 MINT-7947479
    TBL1XR1Q9BZK72MINT-7945693 MINT-7947479
    TCP1P179872MINT-7945693 MINT-7947479
    THRAP3Q9Y2W12MINT-7945693 MINT-7947479
    TIAL1Q010852MINT-7945693 MINT-7947479
    TLN1Q9Y4902MINT-7945693 MINT-7947479
    TRAP1Q129312MINT-7945693 MINT-7947479
    TRIP13Q156452MINT-7945693 MINT-7947479
    TRUB1Q8WWH52MINT-7945693 MINT-7947479
    TSG101Q998162MINT-7945693 MINT-7947479
    TUBA4AP683662MINT-7945693 MINT-7947479
    TUBBP074372MINT-7945693 MINT-7947479
    TUBB4BP683712MINT-7945693 MINT-7947479
    TUBG1P232582MINT-7945693 MINT-7947479
    TUBGCP2Q9BSJ22MINT-7945693 MINT-7947479
    TUBGCP3Q96CW52MINT-7945693 MINT-7947479
    TWF1Q127922MINT-7945693 MINT-7947479
    U2AF1Q010812MINT-7945693 MINT-7947479
    U2AF2P263682MINT-7945693 MINT-7947479
    U2SURPO150422MINT-7945693 MINT-7947479
    UBA5Q9GZZ92MINT-7945693 MINT-7947479
    UBE2MP610812MINT-7945693 MINT-7947479
    UBE2NP610882MINT-7945693 MINT-7947479
    UBL4AP114412MINT-7945693 MINT-7947479
    UNC45AQ9H3U12MINT-7945693 MINT-7947479
    UPF1Q929002MINT-7945693 MINT-7947479
    UPF2Q9HAU52MINT-7945693 MINT-7947479
    USP39Q53GS92MINT-7945693 MINT-7947479
    VASPP505522MINT-7945693 MINT-7899812
    VPS33BQ9H2672MINT-7945693 MINT-7947479
    WDR18Q9BV382MINT-7945693 MINT-7947479
    WDR33Q9C0J82MINT-7945693 MINT-7947479
    XRN2Q9H0D62MINT-7945693 MINT-7947479
    YWHAEP622582MINT-7899812 MINT-7947479
    ZNF638Q149662MINT-7945693 MINT-7947479
    C12orf4Q9NQ893I2D: score=5 
    CLUAP1Q96AJ13I2D: score=5 
    MAXP612443I2D: score=2 
    MMEP084733I2D: score=2 
    ANXA3P124293I2D: score=1 
    ARPC1BO151433I2D: score=1 
    BICD1Q96G013I2D: score=1 
    CASP7P552103I2D: score=1 
    CBX5P459733I2D: score=1 
    CNN3Q154173I2D: score=1 
    DDX3YO155233I2D: score=1 
    ESDP107683I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    GLT25D1Q8NBJ53I2D: score=1 
    GRB10Q133223I2D: score=1 
    HNRNPUL1Q9BUJ23I2D: score=1 
    LARP4BQ926153I2D: score=1 
    LBRQ147393I2D: score=1 
    LEMD3Q9Y2U83I2D: score=1 
    LUC7LQ9NQ293I2D: score=1 
    NCAM2O153943I2D: score=1 
    PITPNBP487393I2D: score=1 
    PPIL1Q9Y3C63I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMB5P280743I2D: score=1 
    PXNP490233I2D: score=1 
    RAB10P610263I2D: score=1 
    RAB2AP610193I2D: score=1 
    RAB5AP203393I2D: score=1 
    RAB5CP511483I2D: score=1 
    RAB6BQ9NRW13I2D: score=1 
    RAB7AP511493I2D: score=1 
    SEC22BO753963I2D: score=1 
    SERBP1Q8NC513I2D: score=1 
    SFNP319473I2D: score=1 
    SLC2A4P146723I2D: score=1 
    STRAPQ9Y3F43I2D: score=1 
    SUN1O949013I2D: score=1 
    SUN2Q9UH993I2D: score=1 
    SYNE2Q8WXH03I2D: score=1 
    TNFP013753I2D: score=1 
    TOP2AP113883I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    ACIN1Q9UKV32MINT-7945693
    ACTA2P627362MINT-7899812
    ACTN2P356092MINT-7899812
    ACTN3Q080432MINT-7899812
    AKAP8O438232MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANKRD18AQ8IVF62MINT-7899812
    ANXA11P509952MINT-7947479
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARGLU1Q9NWB62MINT-7947479
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATP5A1P257052MINT-7899812
    ATRQ135352MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BANK1Q8NDB22MINT-7899812
    BCL7CQ8WUZ02MINT-7945693
    BIDP559572MINT-7947479
    BLMP541322MINT-7945693
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BRIX1Q8TDN62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf13Q8NI282MINT-7947479
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CACNA1SQ136982MINT-7899812
    CALM1P621582MINT-7899812
    CALM2P621582MINT-7899812
    CALM3P621582MINT-7899812
    CAND1Q86VP62MINT-7945693
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CBLP226812MINT-7899812
    CCNT1O605632MINT-7945693
    CDC20Q128342MINT-7947479
    CDK12Q9NYV42MINT-7945693
    CDK3Q005262MINT-7945693
    CEP250Q9BV732MINT-7899812
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CLASP1Q7Z4602MINT-7947479
    CLINT1Q146772MINT-7947479
    CLP1Q929892MINT-7945693
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPS3Q9UNS22MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF4O956392MINT-7945693
    CSDAP169892MINT-7945693
    CSKP412402MINT-7945693
    CTNND1O607162MINT-7947479
    CTTNQ142472MINT-7945693
    CWC15Q9P0132MINT-7947479
    DCTN1Q142032MINT-7945693
    DDB1Q165312MINT-7947479
    DDX1Q924992MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX47Q9H0S42MINT-7947479
    DDX6P261962MINT-7947479
    DESP176612MINT-7899812
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DNAJC13O751652MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DPF2Q927852MINT-7945693
    DTYMKP239192MINT-7947479
    DYNC1LI1Q9Y6G92MINT-7947479
    EBNA1BP2Q998482MINT-7945693
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEFSECP577722MINT-7945693
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF3BP558842MINT-7947479
    EIF3EP602282MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A2Q142402MINT-7947479
    ELF2Q157232MINT-7947479
    ENSG00000258947Q135092MINT-7945693
    EPB41L3Q9Y2J22MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC1Q9NV702MINT-7945693
    EXOC3O606452MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAF1Q9UNN52MINT-7947479
    FAM105BQ96BN82MINT-7945693
    FANCD2Q9BXW92MINT-7947479
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GAPDHP044062MINT-7947479
    GATAD2BQ8WXI92MINT-7945693
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNA14O958372MINT-7945693
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GSPT1P151702MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    GTPBP4Q9BZE42MINT-7945693
    H1F0P073052MINT-7899812
    HAUS7Q998712MINT-7947479
    HIC2Q96JB32MINT-7947479
    HIST1H1CP164032MINT-7899812
    HIST1H1TP224922MINT-7899812
    HIST1H2AGP0C0S82MINT-7899812
    HIST1H2AIP0C0S82MINT-7899812
    HIST1H2AKP0C0S82MINT-7899812
    HIST1H2ALP0C0S82MINT-7899812
    HIST1H2AMP0C0S82MINT-7899812
    HIST1H2BDP588762MINT-7899812
    HIST1H4AP628052MINT-7899812
    HIST1H4BP628052MINT-7899812
    HIST1H4CP628052MINT-7899812
    HIST1H4DP628052MINT-7899812
    HIST1H4EP628052MINT-7899812
    HIST1H4FP628052MINT-7899812
    HIST1H4HP628052MINT-7899812
    HIST1H4IP628052MINT-7899812
    HIST1H4JP628052MINT-7899812
    HIST1H4KP628052MINT-7899812
    HIST1H4LP628052MINT-7899812
    HIST2H4AP628052MINT-7899812
    HIST2H4BP628052MINT-7899812
    HIST4H4P628052MINT-7899812
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPRO433902MINT-7945693
    HSPA6P170662MINT-7947479
    HTATSF1O437192MINT-7945693
    HUWE1Q7Z6Z72MINT-7947479
    IKBKAPO951632MINT-7947479
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    IPO7O953732MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KIAA1279Q96EK52MINT-7945693
    KIF27Q86VH22MINT-7945693
    KPNA1P522942MINT-7945693
    KRT17Q046952MINT-7899812
    KRT18P057832MINT-7899812
    KRT8P057872MINT-7899812
    KTI12Q96EK92MINT-7945693
    LAS1LQ9Y4W22MINT-7947479
    LDLRAP1Q5SW962MINT-7945693
    LENG9Q96B702MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC47Q8N1G42MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAGEE2Q8TD902MINT-7947479
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K4P459852MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MBD3O959832MINT-7945693
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MELKQ146802MINT-7947479
    METTL13Q8N6R02MINT-7945693
    MLH1P406922MINT-7945693
    MLKLQ8NB162MINT-7945693
    MLL2O146862MINT-7945693
    MPP2Q141682MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    MYH11P357492MINT-7899812
    MYH13Q9UKX32MINT-7899812
    MYH2Q9UKX22MINT-7899812
    MYH3P110552MINT-7899812
    MYH7P128832MINT-7899812
    MYL12AP191052MINT-7899812
    MYL3P085902MINT-7899812
    MYLK2Q9H1R32MINT-7899812
    NAT10Q9H0A02MINT-7947479
    NCAPGQ9BPX32MINT-7945693
    NCLP193382MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NF1P213592MINT-7947479
    NFICP086512MINT-7945693
    NOLC1Q149782MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NRG1Q022972MINT-7947479
    NUDT21O438092MINT-7947479
    NUP107P577402MINT-7947479
    NUP37Q8NFH42MINT-7945693
    NUP93Q8N1F72MINT-7947479
    OLA1Q9NTK52MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PARP1P098742MINT-7947479
    PARP4Q9UKK32MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCF11O949132MINT-7945693
    PCNTO956132MINT-7947479
    PDCD6IPQ8WUM42MINT-7945693
    PELOQ9BRX22MINT-7947479
    PELP1Q8IZL82MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKP3Q9Y4462MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLEQ078642MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP2R1BP301542MINT-7945693
    PRCCQ927332MINT-7947479
    PRKAG1P546192MINT-7945693
    PRPF3O433952MINT-7947479
    PRPF40AO754002MINT-7945693
    PRPF4BQ135232MINT-7947479
    PSTPIP2Q9H9392MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUF60Q9UHX12MINT-7945693
    PUM1Q146712MINT-7947479
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RAD21O602162MINT-7945693
    RAE1P784062MINT-7945693
    RAVER1Q8IY672MINT-7947479
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM7Q9Y5802MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    RNF2Q994962MINT-7945693
    RPL12P300502MINT-7945693
    RPL19P840982MINT-7945693
    RPL23AP627502MINT-7945693
    RPL24P837312MINT-7947479
    RPL3P390232MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS13P622772MINT-7947479
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RXRBP287022MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC23BQ154372MINT-7945693
    SEC24CP539922MINT-7947479
    SEC31BQ9NQW12MINT-7945693
    SENP3Q9H4L42MINT-7947479
    SEPT7Q161812MINT-7945693
    SF3A2Q154282MINT-7947479
    SF3B4Q154272MINT-7945693
    SHC1P293532MINT-7947479
    SHOC2Q9UQ132MINT-7945693
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA2P515312MINT-7945693
    SNAI1O958632MINT-8313510
    SNAPC4Q5SXM22MINT-7947479
    SND1Q7KZF42MINT-7945693
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPB2P085792MINT-7945693
    SNRPD1P623142MINT-7947479
    SNRPEP623042MINT-7947479
    SNUPNO951492MINT-7945693
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SOGA2Q9Y4B52MINT-7947479
    SPATA5L1Q9BVQ72MINT-7945693
    SPENQ96T582MINT-7947479
    SQSTM1Q135012MINT-7945693
    SREK1Q8WXA92MINT-7947479
    SRP19P091322MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF4Q081702MINT-7947479
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG1Q8WVM72MINT-7945693
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SUPV3L1Q8IYB82MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TAF9Q165942MINT-7945693
    TANC2Q9HCD62MINT-7947479
    TAOK1Q7L7X32MINT-7945693
    TGIF2LYQ8IUE02MINT-7899812
    THAP1Q9NVV92MINT-7947479
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TOX4O948422MINT-7945693
    TPM1P094932MINT-7899812
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRIM21P194742MINT-7947479
    TRIP12Q146692MINT-7945693
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TSC2P498152MINT-7899812
    TTKP339812MINT-7945693
    TTNQ8WZ422MINT-7899812
    TUBA1CQ9BQE32MINT-7947479
    TUBA3EQ6PEY22MINT-7945693
    TUBB1Q9H4B72MINT-7945693
    TUBB2AQ138852MINT-7899812
    TUBB3Q135092MINT-7945693
    TUBGCP4Q9UGJ12MINT-7947479
    TUFMP494112MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBE2SQ167632MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UMPSP111722MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP42Q9H9J42MINT-7899812
    USP48Q86UV52MINT-7945693
    VPS33AQ96AX12MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    WRNIP1Q96S552MINT-7947479
    XPO5Q9HAV42MINT-7947479
    XPO6Q96QU82MINT-7945693
    XRCC6P129562MINT-7945693
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YTHDC2Q9H6S02MINT-7945693
    YWHAHQ049172MINT-7899812
    YY1P254902MINT-7945693
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF326Q5BKZ12MINT-7945693
    CASP2ENSP000003126644STRING: ENSP00000312664
    MLIPENSP000002748974STRING: ENSP00000274897
    VAV1ENSP000003022694STRING: ENSP00000302269
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    RUFY3ENSP000003703944STRING: ENSP00000370394
    SMG1ENSP000004025154STRING: ENSP00000402515
    SUMO2ENSP000004059654STRING: ENSP00000405965
    EIF6ENSP000003635594STRING: ENSP00000363559
    KNCNENSP000003796074STRING: ENSP00000379607
    SIRT7ENSP000003294664STRING: ENSP00000329466
    PPP1CCENSP000003350844STRING: ENSP00000335084
    TP53BP1ENSP000003714754STRING: ENSP00000371475
    FOXO1ENSP000003688804STRING: ENSP00000368880
    --C9JW422MINT-7947479
    --Q8WU302MINT-7945693 MINT-7947479
    --Q130512MINT-7947479
    --Q7Z48 M2MINT-7945693 MINT-7947479
    --P102182MINT-6733492 MINT-6733499
    --Q8N5322MINT-7945693
    --XP_2922MINT-7945693
    --Q9NXK92MINT-7945693 MINT-7947479
    --Q133442MINT-7947479
    --P042962MINT-6741532
    --Q9Y4B32MINT-7945693
    --ENSP000002779164MINT-7945693 MINT-7947479 STRING: ENSP00000277916
    --Q3BDU53I2D: score=3 
    --Q9H6S72MINT-7947479
    --O463852MINT-7902416
    --XP_2903452MINT-7947479
    --Q137272MINT-7945693 MINT-7947479
    --Q9UNL72MINT-7945693 MINT-7947479
    --O432092MINT-7945693 MINT-7947479
    --Q8N1C02MINT-7945693 MINT-7947479
    --Q8N5193I2D: score=3 
    --Q5TCJ43I2D: score=3 
    --A8K9D92MINT-7947479
    --Q5I6Y53I2D: score=3 
    --Q8N5H62MINT-7945693 MINT-7947479
    --XP_0397022MINT-7945693 MINT-7947479
    --Q96PK22MINT-7947479
    --Q9D6662MINT-7893761
    --Q9HBD42MINT-7945693 MINT-7947479
    --Q9Y2L02MINT-7945693 MINT-7947479
    --Q5I6Y63I2D: score=3 
    --Q96QI32MINT-7945693
    --XP_0862MINT-7945693
    --ENSP000003390714MINT-7945693 STRING: ENSP00000339071
    --Q6UYC33I2D: score=3 
    --O957662MINT-7947479
    --Q8TEF12MINT-7947479
    --ENSP000003230634MINT-7947479 STRING: ENSP00000323063
    --O602892MINT-7947479
    --Q86TR82MINT-7945693 MINT-7947479
    --Q9NVY62MINT-7945693 MINT-7947479
    --Q7Z6R02MINT-7947479
    --Q9BX722MINT-7945693
    --ENSP000003419664STRING: ENSP00000341966
    --P102152MINT-6733485 MINT-6733478
    --Q8N8M92MINT-7947479
    --ENSP000002955614MINT-7945693 STRING: ENSP00000295561
    --Q160832MINT-7945693
    --O605352MINT-7945693
    --Q5I6Y43I2D: score=3 
    --ENSP000003060434STRING: ENSP00000306043
    --Q7Z5G22MINT-7945693
    --Q8N2742MINT-7945693 MINT-7947479
    --ENSP000004079504STRING: ENSP00000407950
    --Q8NBY12MINT-7945693
    --Q9NXD32MINT-7947479
    --Q1424 E2MINT-7947479
    --Q9BTU22MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0006997nucleus organization ----
    GO:0006998nuclear envelope organization IEA--


    LMNA for ontologies           About GeneDecksing



    Drugs & Compounds
    for LMNA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LMNA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMNA
    10/18 Novoseek chemical compound relationships for LMNA gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nelfinavir 23.7 2 14600514 (1), 18344876 (1)
    rosiglitazone 18 2 14510863 (2)
    indinavir 17.1 4 14600514 (1), 16184025 (1), 12844477 (1)
    zinc 14.2 12 16278265 (1), 19494770 (1), 19323649 (1), 15998779 (1) (see all 7)
    retinoic acid 12.4 18 15219855 (3), 10694499 (3), 12844477 (2), 11478838 (1) (see all 8)
    deoxyribonucleic acid 6.22 1 12015247 (1)
    calcium 0.975 2 1467310 (1), 19144047 (1)
    cholesterol 0 4 11136544 (1), 12524233 (1), 17994215 (1), 15205219 (1)
    atp 0 6 1965140 (2), 15892163 (1), 2004657 (1)
    lipid 0 3 20130076 (2), 16181372 (1)

    Search CenterWatch for drugs/clinical trials and news about LMNA 

    Transcripts
    for LMNA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LMNA gene (4 alternative transcripts): 
    NM_001257374.1  NM_005572.3  NM_170707.3  NM_170708.3  

    Unigene Cluster for LMNA:

    Lamin A/C
    Hs.594444  [show with all ESTs]
    Unigene Representative Sequence: NM_170707
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000502751 ENST00000368301(uc001fnf.1) ENST00000495341 ENST00000470835
    ENST00000515711 ENST00000368300(uc001fng.2 uc001fni.2 uc009wro.1 uc001fnk.2)
    ENST00000470199 ENST00000478063 ENST00000469565 ENST00000368299 ENST00000502357
    ENST00000448611(uc010pgz.1) ENST00000515459 ENST00000368297 ENST00000504687
    ENST00000473598 ENST00000515824 ENST00000496738(uc001fnj.2 uc010pha.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): LMNA
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMNA
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmid: LMNA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LMNA (see all 7)
    OriGene shRNA RFP: LMNA
    OriGene siRNA: LMNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMNA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LMNA (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LMNA (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LMNA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMNA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMNA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMNA

    Additional cDNA sequence: 

    AF381029.1 AK026584.1 AK056143.1 AK056191.1 AK057997.1 AK097801.1 AK098128.1 AK122732.1 
    AK130179.1 AK294217.1 AK295390.1 AK309539.1 AY357727.1 AY528714.1 AY847595.1 AY847596.1 
    AY847597.1 BC000511.2 BC003162.1 BC014507.1 BC018863.2 BC033088.1 M13451.1 M13452.1 
    NR_047544.1 NR_047545.1 X03444.1 X03445.1 

    24/79 DOTS entries (see all 79):

    DT.100891747  DT.91871177  DT.92469899  DT.95246279  DT.100891714  DT.95294580  DT.100891710  DT.121347135 
    DT.100891740  DT.92469913  DT.100891733  DT.92057489  DT.101986435  DT.121347131  DT.121347084  DT.100891726 
    DT.95322263  DT.99987681  DT.121347143  DT.121347120  DT.100891698  DT.100039687  DT.100891751  DT.320389 

    24/1597 AceView cDNA sequences (see all 1597):

    BG260177 CA395830 CA423881 CB528890 CB138659 BE408991 W23629 BU542321 
    AU139796 BE336696 CA406353 CA841908 BU174781 CB130594 AI219557 BQ686823 
    BE902429 BM795146 BE885040 BE273844 BQ431561 CB152958 CD367718 BQ933009 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LMNA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                            -                                   -                                 
    SP2:                                            -                                   -           -                     
    SP3:                                            -                                                                     
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for LMNA

    Expression
    for LMNA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGGGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LMNA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Secondary follicles (Primary Cell)Ovary, Reproductive System

    See LMNA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMNA

    SOURCE GeneReport for Unigene cluster: Hs.594444

    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is
    prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where
    it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In
    normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response
    to oxidative stress

        SABiosciences Expression via Pathway-Focused PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LMNA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMNA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMNA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMNA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    Orthologs
    for LMNA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LMNA gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 73(a)
    55(a)
    		 1 ↔ many
    1 ↔ many
    		 GL344336.1(8415-20568)
    2(41214999-41216574)
    African clawed frog
    (Xenopus laevis)    		 Amphibia lmna-A2 lamin A/C 76.67(n)    X06345.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lmna2 lamin A 76.11(n)   195815  AF397016.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta LamC3 nuclear envelope reassembly 37(a)
    (best of 2)    		   51B1   --


    ENSEMBL Gene Tree for LMNA (if available)
    TreeFam Gene Tree for LMNA (if available) 

    Paralogs
    for LMNA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMNA gene
    LMNB12  SYNM2  VIM2  INA2  NES2  PRPH2  DES2  NEFM2  
    LMNB22  NEFH2  GFAP2  
    5 SIMAP similar genes for LMNA using alignment to 9 protein entries:     LMNA_HUMAN (see all proteins):
    LMNB1    LMNB2    VIM    KRT5    keratin

    LMNA for paralogs           About GeneDecksing



    Genomic Variants
    for LMNA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1087 NCBI SNPs in LMNA are shown (see all 1087)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115496691,2
    		Cnon-pathogenic156084714(+) CATGGA/GGACCC 7 E G mis1 ese30--------
    rs115496681,2
    		C,F,non-pathogenic156084760(+) GCCAGC/TTCCAC 7 S syn15Minor allele frequency- T:0.01NA NS EU 2677
    rs413138801,2
    		C,F,non-pathogenic156100408(+) TTTAGC/TAATAC 10 C R syn12Minor allele frequency- T:0.00NA EU 5759
    rs803568051,2
    		C,F,non-pathogenic156100489(+) GAGGCC/TGCACT 10 A syn13Minor allele frequency- T:0.01CSA NA 4524
    rs121175521,2
    		C,F,H,non-pathogenic156104292(+) GAACTG/AGACTT 10 /L nc-transcript-variantsyn112Minor allele frequency- A:0.01NS EA NA EU 7141
    rs112644421,2
    		C,F,non-pathogenic156104375(+) CTTGGA/G/TCTGGG 6 -- int17NA WA EA EU 1608
    rs112644431,2
    		C,non-pathogenic156104392(+) NNNNCC/TAGCTG 6 -- int15Minor allele frequency- T:0.05NA WA EA 362
    rs803568071,2
    		Cnon-pathogenic156104586(+) CTCCAA/C/GCCCTT 6 -- int10--------
    rs115496661,2
    		C,Hnon-pathogenic156104647(+) TTGACA/CATGGG 10 N H mis1 ese34Minor allele frequency- C:0.00NS EA 406
    rs582358101,2
    		Cnon-pathogenic156104679(+) CGGCTA/GGCGGA 10 L nc-transcript-variantsyn10--------

    HapMap Linkage Disequilibrium report for LMNA (156052364 - 156109880 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LMNA: --
    Human Gene Mutation Database (HGMD): LMNA

    Locus Specific Mutation Databases (LSDB): LMNA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LMNA
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNA

    Disorders / Diseases
    for LMNA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LMNA for disorders           About GeneDecksing

    OMIM gene information: 150330   
    OMIM disorders: 181350  115200  151660  605588  159001  248370  176670  275210  610140  
    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
  • Defects in LMNA are the cause of Emery-Dreifuss muscular dystrophy type 2, autosomal dominant (EDMD2)
    • [MIM:181350]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the
    nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with
    cardiac conduction defects
  • Defects in LMNA are the cause of Emery-Dreifuss muscular dystrophy type 3, autosomal recessive (EDMD3)
    • [MIM:181350]
  • Defects in LMNA are the cause of cardiomyopathy dilated type 1A (CMD1A) [MIM:115200]. Dilated cardiomyopathy
    • is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart
    failure and arrhythmia. Patients are at risk of premature death
  • Defects in LMNA are the cause of familial partial lipodystrophy type 2 (FPLD2) [MIM:151660]; also known as
    • familial partial lipodystrophy Dunnigan type. A disorder characterized by the loss of subcutaneous adipose tissue in
    the lower parts of the body (limbs, buttocks, trunk). It is accompanied by an accumulation of adipose tissue in the
    face and neck causing a double chin, fat neck, or cushingoid appearance. Adipose tissue may also accumulate in the
    axillae, back, labia majora, and intraabdominal region. Affected patients are insulin-resistant and may develop
    glucose intolerance and diabetes mellitus after age 20 years, hypertriglyceridemia, and low levels of high density
    lipoprotein cholesterol
  • Defects in LMNA are the cause of limb-girdle muscular dystrophy type 1B (LGMD1B) [MIM:159001]. LGMD1B is an
    • autosomal dominant degenerative myopathy with age-related atrioventricular cardiac conduction disturbances, dilated
    cardiomyopathy, and the absence of early contractures. LGMD1B is characterized by slowly progressive skeletal muscle
    weakness of the hip and shoulder girdles. Muscle biopsy shows mild dystrophic changes
  • Defects in LMNA are the cause of Charcot-Marie-Tooth disease type 2B1 (CMT2B1) [MIM:605588]. CMT2B1 is a form
    • of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.
    Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and
    histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2.
    Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin
    alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and
    atrophy. CMT2B1 inheritance is autosomal recessive
  • Defects in LMNA are the cause of Hutchinson-Gilford progeria syndrome (HGPS) [MIM:176670]. HGPS is a rare
    • genetic disorder characterized by features reminiscent of marked premature aging. Note=HGPS is caused by the toxic
    accumulation of a mutant form of lamin-A/C. This mutant protein, called progerin, acts to deregulate mitosis and DNA
    damage signaling, leading to premature cell death and senescence. Progerin lacks the conserved ZMPSTE24/FACE1 cleavage
    site and therefore remains permanently farnesylated. Thus, although it can enter the nucleus and associate with the
    nuclear envelope, it cannot incorporate normally into the nuclear lamina
  • Defects in LMNA are the cause of cardiomyopathy dilated with hypergonadotropic hypogonadism (CMDHH)
    • [MIM:212112]. A disorder characterized by the association of genital anomalies, hypergonadotropic hypogonadism and
    dilated cardiomyopathy. Patients can present other variable clinical manifestations including mental retardation,
    skeletal anomalies, scleroderma-like skin, graying and thinning of hair, osteoporosis. Dilated cardiomyopathy is
    characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and
    arrhythmia
  • Defects in LMNA are the cause of mandibuloacral dysplasia with type A lipodystrophy (MADA) [MIM:248370]. A
    • disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture,
    progeroide appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with
    loss of subcutaneous fat from the extremities. Adipose tissue in the face, neck and trunk is normal or increased
  • Defects in LMNA are a cause of lethal tight skin contracture syndrome (LTSCS) [MIM:275210]; also known as
    • restrictive dermopathy (RD). Lethal tight skin contracture syndrome is a rare disorder mainly characterized by
    intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal
    hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and
    eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint
    contractures and an early neonatal lethal course. Liveborn children usually die within the first week of life. The
    overall prevalence of consanguineous cases suggested an autosomal recessive inheritance
  • Defects in LMNA are the cause of heart-hand syndrome Slovenian type (HHS-Slovenian) [MIM:610140]. Heart-hand
    • syndrome (HHS) is a clinically and genetically heterogeneous disorder characterized by the co-occurrence of a
    congenital cardiac disease and limb malformations
  • Defects in LMNA are the cause of muscular dystrophy congenital LMNA-related (MDCL) [MIM:613205]. It is a form
    • of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia,
    muscle weakness and often with joint contractures

    20/126 diseases for LMNA (see all 126):    About MalaCards
    limb-girdle muscular dystrophy    emery-dreifuss muscular dystrophy    charcot-marie-tooth disease    muscular dystrophy
    progeria    charcot-marie-tooth disease type 2b1    charcot-marie-tooth disease type 2    emery-dreifuss muscular dystrophy, ar
    emery-dreifuss muscular dystrophy, ad    pelger-huet anomaly    cardiomyopathy    familial partial lipodystrophy
    dilated cardiomyopathy    charcot-marie-tooth neuropathy    heart-hand syndrome, slovenian type    proximal spinal muscular atrophy
    lipodystrophy    tooth disease    charcot-marie-tooth neuropathy type 2    restrictive dermopathy

    9 diseases from the University of Copenhagen DISEASES database for LMNA:
    Progeria     Lipodystrophy     Dilated cardiomyopathy     Myopathy
    Neuropathy     Congenital heart block     Werner syndrome     Acanthosis nigricans
    Genetic disorder

    10/73 Novoseek disease relationships for LMNA gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, familial partial 97.8 88 12015247 (3), 11397881 (2), 18364375 (2), 19622949 (2) (see all 63)
    progeria 97 77 15479179 (2), 17076270 (2), 16671095 (2), 17469202 (2) (see all 59)
    muscular dystrophy emery-dreifuss 96.5 48 19589462 (2), 16697197 (2), 12685553 (1), 20225280 (1) (see all 41)
    emery-dreifuss muscular dystrophy, autosomal dominant 96.4 21 11532159 (1), 10587585 (1), 11102973 (1), 15639119 (1) (see all 19)
    lgmd1b 95.4 28 10814726 (4), 15678000 (3), 19070492 (2), 15668447 (1) (see all 15)
    mandibuloacral dysplasia 95.3 25 16278265 (2), 16046620 (1), 16364671 (1), 15843404 (1) (see all 16)
    partial lipodystrophy 93.2 32 15817509 (1), 11102973 (1), 12524233 (1), 15773753 (1) (see all 26)
    lipodystrophy 90 59 18077842 (3), 11078466 (2), 12788894 (2), 12844477 (2) (see all 37)
    acroosteolysis 86.4 4 16278265 (1), 17848409 (1), 18554282 (1)
    lipodystrophy, congenital generalized 85.4 4 19169477 (1), 19494770 (1), 14516935 (1)

    GeneTests: LMNA
    Charcot-Marie-Tooth Neuropathy Type 2
    Emery-Dreifuss Muscular Dystrophy
    LMNA-Related Dilated Cardiomyopathy
    Hutchinson-Gilford Progeria
    Dilated Cardiomyopathy

    Genetic Association Database (GAD): LMNA
    Human Genome Epidemiology (HuGE) Navigator: LMNA (37 documents)

    Export disorders for LMNA gene to outside databases

    Publications
    for LMNA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMNA gene, integrated from 9 sources (see all 763):
    (articles sorted by number of sources associating them with LMNA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. (PubMed id 12920062)1, 2, 4, 9 Sebillon P.... Komajda M. (2003)
    2. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. (PubMed id 15219508)1, 2, 4, 9 Hermida-Prieto M....Crespo-Leiro M. (2004)
    3. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). (PubMed id 12768443)1, 2, 9 Cao H. and Hegele R.A. (2003)
    4. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. (PubMed id 11897440)1, 2, 9 Arbustini E....Tavazzi L. (2002)
    5. Variation in the lamin A/C gene: associations with metabolic syndrome. (PubMed id 15205219)1, 4, 9 Steinle N.I....Shuldiner A.R. (2004)
    6. LMNA mutations in atypical Werner's syndrome. (PubMed id 12927431)1, 2, 9 Chen L.... Oshima J. (2003)
    7. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. (PubMed id 12628721)1, 2, 9 Taylor M.R.G.... Mestroni L. (2003)
    8. Novel and recurrent mutations in lamin A/C in patients with Emery- Dreifuss muscular dystrophy. (PubMed id 11503164)1, 2, 9 Brown C.A.... Spence J.E. (2001)
    9. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. (PubMed id 10655060)1, 2, 9 Shackleton S.... Trembath R.C. (2000)
    10. Collagen expression in fibroblasts with a novel LMNA mutation. (PubMed id 17150192)1, 2, 9 Nguyen D....Oshima J. (2007)

    External Searches for LMNA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LMNA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4000 HGNC: 6636 AceView: LMNA Ensembl:ENSG00000160789 euGenes: HUgn4000
    ECgene: LMNA Kegg: 4000 H-InvDB: LMNA

    Other Databases showing LMNA gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing LMNA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMNA Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for LMNA Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LMNA

    Intellectual Property
    for LMNA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LMNA gene:
    Search GeneIP for patents involving LMNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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