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LMNA Gene

protein-coding   GIFtS: 75
GCID: GC01P156053

Lamin A/C

(Previous names: cardiomyopathy, dilated 1A (autosomal dominant), limb girdle...)
(Previous symbols: LMN1, CMD1A, LGMD1B, PRO1, LMNL1)
  See LMNA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lamin A/C1 2     70 KDa Lamin2
LMN11 2 3 5     CDCD12
CMD1A1 2 5     CDDC2
LGMD1B1 2 5     CMT2B12
LMNL11 2     FPL2
PRO11 2     FPLD2
Lamin A/C-Like 11 2     IDC2
EMD22 5     LDP12
FPLD22 5     LFP2
HGPS2 5     LMNC2
Cardiomyopathy, Dilated 1A (Autosomal Dominant)1     lamin2
Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant)1     prelamin-A/C2
Progeria 1 (Hutchinson-Gilford Type)1     Renal Carcinoma Antigen NY-REN-322

External Ids:    HGNC: 66361   Entrez Gene: 40002   Ensembl: ENSG000001607897   OMIM: 1503305   UniProtKB: P025453   
ORGUL members:         

Export aliases for LMNA gene to outside databases

Previous GC identifers: GC01P153921 GC01P151817 GC01P152830 GC01P153301 GC01P152897 GC01P154318 GC01P127446


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMNA Gene:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.
The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina
matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be
involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A
and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy,
dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. (provided by
RefSeq, Apr 2012)

GeneCards Summary for LMNA Gene:
LMNA (lamin A/C) is a protein-coding gene. Diseases associated with LMNA include laminopathy type decaudain-vigouroux, and lmna-related cardiocutaneous progeria syndrome. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is DES.

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
maintain the volume and strength of skeletal muscle and bone
Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
senescence

Gene Wiki entry for LMNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMNA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMNA promoter sequence
   Search Chromatin IP Primers for LMNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

LMNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156053:  view genomic region     (about GC identifiers)

Start:
156,052,364 bp from pter      End:
156,109,880 bp from pter
Size:
57,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545 (See protein sequence)
Recommended Name: Prelamin-A/C precursor  
Size: 664 amino acids; 74139 Da
Subunit: Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1
and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43 (By similarity). Proteolytically processed
isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP; may
regulate MLIP localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability.
Interacts with SUV39H1; the interaction increases stability of SUV39H1
Miscellaneous: There are three types of lamins in human cells: A, B, and C
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Sequence caution: Sequence=CAA27173.1; Type=Frameshift; Positions=582;
Selected PDB 3D structures from and Proteopedia for LMNA (see all 9):
1IFR (3D)        1IVT (3D)        1X8Y (3D)        2XV5 (3D)        2YPT (3D)        3GEF (3D)    
Secondary accessions: B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3
Q969I8 Q96JA2
Alternative splicing: 6 isoforms:  P02545-1   P02545-2   P02545-3   P02545-4   P02545-5   P02545-6   (Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage)

Explore the universe of human proteins at neXtProt for LMNA: NX_P02545

Explore proteomics data for LMNA at MOPED

Post-translational modifications: 

  • Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in
    regulating lamin associations1
  • Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The
    prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the
    last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15
    C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these
    blocks cleavage1
  • Sumoylation is necessary for the localization to the nuclear envelope1
  • Farnesylation of prelamin-A/C facilitates nuclear envelope targeting1
  • Ubiquitination2 at Lys78, Lys108, Lys135, Lys144, Lys171, Lys181, Lys201, Lys208, Lys265, Lys270,
                                 Lys311, Lys378, Lys470, Lys486
  • Modification sites at PhosphoSitePlus

  • See LMNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001244303.1  NP_001269553.1  NP_001269554.1  NP_001269555.1  NP_005563.1  NP_733821.1  NP_733822.1  

    ENSEMBL proteins: 
     ENSP00000357284   ENSP00000357283   ENSP00000357282   ENSP00000395597   ENSP00000424518  
     ENSP00000357280   ENSP00000426535   ENSP00000421821   ENSP00000424977   ENSP00000292304  
     ENSP00000355292   ENSP00000376164  
    Reactome Protein details: P02545

    LMNA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for LMNA
    OriGene Protein Over-expression Lysate for LMNA
    OriGene MassSpec for LMNA
    OriGene Custom Protein Services for LMNA
    GenScript Custom Purified and Recombinant Proteins Services for LMNA
    Novus Biologicals LMNA Protein
    Novus Biologicals LMNA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LMNA
    Cloud-Clone Corp. Proteins for LMNA

     
    Search eBioscience for Proteins for LMNA 

     
    antibodies-online proteins for LMNA (4 products) 

     
    antibodies-online peptides for LMNA

    LMNA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNA  (lamin A/C)
    OriGene Antibodies for LMNA
    OriGene Custom Antibody Services for LMNA
    Novus Biologicals LMNA Antibodies
    Abcam antibodies for LMNA (Q6UYC3, P20700, P02545)
    Cloud-Clone Corp. Antibodies for LMNA
    ThermoFisher Antibody for LMNA
    antibodies-online antibodies for LMNA (209 products) 

    LMNA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMNA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMNA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMNA
    Cloud-Clone Corp. CLIAs for LMNA
    Search eBioscience for ELISAs for LMNA 
    antibodies-online kits for LMNA (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF5: Intermediate filaments type V, lamins

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry P02545

    ProtoNet protein and cluster: P02545

    2 Blocks protein domains:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with LMNA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMNA_HUMAN, P02545
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
    nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
    chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
    nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
    of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
    osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
    maintain the volume and strength of skeletal muscle and bone
    Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
    damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
    senescence

         Genatlas biochemistry entry for LMNA:
    lamin,types A and C,common gene,alternatively spliced isoforms

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS3453101
    GO:0005515protein binding IPI10381623
         
    Find genes that share ontologies with LMNA           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LMNA:
     Increased S DNA content  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Lmna) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    Find genes that share phenotypes with LMNA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LMNA: Lmnatm6Lgf Lmnatm1Stw Lmnatm4Lgf Lmnatm5Lgf Lmnatm1Lgf Lmnatm2Lgf

       genOway: Develop your customized and physiologically relevant rodent model for LMNA

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMNA:
    hsa-mir-615-3p (MIRT040169), hsa-mir-296-3p (MIRT038445), hsa-let-7a-5p (MIRT052409), hsa-mir-340-5p (MIRT019532), hsa-mir-124-3p (MIRT022394), hsa-mir-9-5p (MIRT021388), hsa-let-7e-5p (MIRT051592)

    Block miRNA regulation of human, mouse, rat LMNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMNA

    Clone
    Products:
         
    OriGene clones in human, mouse for LMNA (see all 18)
    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    Sino Biological Human cDNA Clone for LMNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Addgene plasmids for LMNA 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMNA
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMNA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMNA_HUMAN, P02545: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of
    prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the
    farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for
    proper localization of non-farnesylated prelamin-A/C
    LMNA_HUMAN, P02545: Isoform C: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS3453101
    GO:0005638lamin filament TAS10080180
    GO:0005652nuclear lamina TAS8344919
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with LMNA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LMNA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    Breakdown of the nuclear lamina0.00
    FAS pathway and Stress induction of HSP regulation0.44
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    5Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00
    Clearance of Nuclear Envelope Membranes from Chromatin0.00


    Find genes that share SuperPaths with LMNA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LMNA
        Caspase Cascade
    Granzyme Pathway
    Fas Signaling

    3 Cell Signaling Technology (CST) Pathways for LMNA
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for LMNA
        Adipogenesis
    FAS pathway and Stress induction of HSP regulation
    Arrhythmogenic right ventricular cardiomyopathy
    Caspase cascade in apoptosis


    1 Reactome Pathway for LMNA
        XBP1(S) activates chaperone genes

    1 PharmGKB Pathway for LMNA
        Antiarrhythmic Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for LMNA):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMNA (P025451, 2, 3 ENSP000003572834) via UniProtKB, MINT, STRING, and/or I2D (see all 1002)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI31, 2, 3, ENSP000003854794EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    HIST2H3DQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0006997nucleus organization ----

    Find genes that share ontologies with LMNA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMNA

    Selected Novoseek inferred chemical compound relationships for LMNA gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nelfinavir 23.7 2 14600514 (1), 18344876 (1)
    rosiglitazone 18 2 14510863 (2)
    indinavir 17.1 4 14600514 (1), 16184025 (1), 12844477 (1)
    zinc 14.2 12 16278265 (1), 19494770 (1), 19323649 (1), 15998779 (1) (see all 7)
    retinoic acid 12.4 18 15219855 (3), 10694499 (3), 12844477 (2), 11478838 (1) (see all 8)
    deoxyribonucleic acid 6.22 1 12015247 (1)
    calcium 0.975 2 1467310 (1), 19144047 (1)
    cholesterol 0 4 11136544 (1), 12524233 (1), 17994215 (1), 15205219 (1)
    atp 0 6 1965140 (2), 15892163 (1), 2004657 (1)
    lipid 0 3 20130076 (2), 16181372 (1)



    Find genes that share compounds with LMNA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LMNA gene (7 alternative transcripts): 
    NM_001257374.2  NM_001282624.1  NM_001282625.1  NM_001282626.1  NM_005572.3  NM_170707.3  NM_170708.3  

    Unigene Cluster for LMNA:

    Lamin A/C
    Hs.594444  [show with all ESTs]
    Unigene Representative Sequence: NM_170707
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000502751 ENST00000368301(uc001fnf.1) ENST00000495341 ENST00000470835
    ENST00000515711 ENST00000368300(uc001fng.2 uc001fni.2 uc009wro.1 uc001fnk.2)
    ENST00000478063 ENST00000470199 ENST00000469565 ENST00000368299 ENST00000502357
    ENST00000448611(uc010pgz.1) ENST00000515459 ENST00000368297 ENST00000504687
    ENST00000473598 ENST00000515824 ENST00000496738(uc001fnj.2 uc010pha.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA
    Clone
    Products:
         
    OriGene clones in human, mouse for LMNA (see all 18)
    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Addgene plasmids for LMNA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
      QuantiTect SYBR Green Assays in human, mouse, rat LMNA
      QuantiFast Probe-based Assays in human, mouse, rat LMNA

    Additional mRNA sequence: 

    AF381029.1 AK026584.1 AK056143.1 AK056191.1 AK057997.1 AK097801.1 AK098128.1 AK122732.1 
    AK130179.1 AK294217.1 AK295390.1 AK309539.1 AY357727.1 AY528714.1 AY847595.1 AY847596.1 
    AY847597.1 BC000511.2 BC003162.1 BC014507.1 BC018863.2 BC033088.1 M13451.1 M13452.1 
    NR_047544.1 NR_047545.1 X03444.1 X03445.1 

    Selected DOTS entries (see all 79):

    DT.100891747  DT.91871177  DT.92469899  DT.95246279  DT.100891714  DT.95294580  DT.100891710  DT.121347135 
    DT.92469913  DT.100891740  DT.100891733  DT.92057489  DT.101986435  DT.121347131  DT.121347084  DT.100891726 
    DT.99987681  DT.95322263  DT.100039687  DT.121347143  DT.121347120  DT.100891698  DT.100891751  DT.320389 

    1597 AceView cDNA sequences (see top 24):

    CB150408 AL602697 BU528517 BU626255 BG831209 BU190818 BQ689214 BU543235 
    BM913668 CA436010 BM828139 AI654262 BQ219558 BQ215790 CD674183 BU178121 
    BM836839 BM763030 BE311540 AW245428 AU120748 BM837113 CB130594 BM785968 
    AL549782 BM786338 BQ962961 AK097801 BQ945294 BM980869 BQ686442 AU139796 
    BU177195 BG829463 BU751814 BE731167 CD515351 BQ878386 AI129393 BQ952116 
    BE273844 CA454200 BM830530 BM796577 AL515889 BQ653662 AK130179 CR619166 
    BQ683291 BQ934324 CB136735 CF132672 BQ925263 CR598617 BU163354 BU149036 
    CA439573 CA843032 BQ962417 BU855257 BU542321 BG260177 BG749019 AI440199 
    BM907256 BM563534 BQ883374 BG323982 W23629 AK056191 BQ932553 CA423881 
    BQ887524 CB130289 BQ576269 BM795614 BF984822 BU527683 BQ233157 BE277289 
    BM560522 CA389373 CR619146 CF125977 AL527048 BM759463 BI861477 BU943871 
    AA374074 BM855193 BQ933372 BE741126 AF381029 BQ428464 CD364753 BU150107 
    BU624859 CB528890 BE885040 BI835620 BM560647 BM998141 CB124946 BU195500 
    BQ689912 BU174781 CB140636 AK122732 CA396080 BC018863 AI417383 BQ431561 
    BQ219808 BQ688734 AI184300 BQ932930 AU134139 AL543932 CD368143 BQ683095 
    BQ935634 AI679597 BG330158 NM_170707 BQ920800 BQ670150 BE277255 BQ689357 
    BQ688714 BU734409 BQ686823 BE732919 BM791141 BE408991 BQ933009 BU190315 
    BM838020 CB124011 CD674047 BC014507 BM726202 BQ225951 BQ892281 BQ933420 
    BM795146 BQ943551 BM819880 CR605674 BU838224 BQ689110 BU155880 BU194709 
    BC000511 BQ428078 CB114427 CB135269 CA406353 CA407855 BQ879747 CR604156 
    BE891004 AI219557 BM837263 AL701184 BE336696 BQ711771 CB124212 CR626536 
    CA432112 BQ233872 AI497918 CB132173 BQ651845 BX406132 CF132166 CB138659 
    CB216124 BM781806 BM786322 BU541082 BU952662 BU527728 BQ899088 CF132636 
    CA420950 BM795382 R74022 CA395830 CB152954 BQ958754 CA488152 BM908250 
    BQ674247 BM759568 BC003162 CB123672 BU528574 R54621 AY357727 AI674212 
    BI964222 BE394840 BM710596 CR622626 BG255527 BM760150 CR600170 BF970433 
    BU845157 CB128404 BQ677957 BM836892 BI908577 BU194876 BQ225298 BQ949985 
    BU158062 BQ954261 BE385996 NM_170708 BU528164 BM725276 BI770050 BF725411 
    BM988801 BQ650325 BG774265 BI822606 AI446447 BQ689334 BE388000 BE550222 
    BE613729 BE394808 BI963905 AI084018 BE384308 BM829434 NM_005572 AK098128 
    CA841908 BU166920 BQ189121 BQ934954 BP871073 BQ898109 AA569105 BM467971 
    CB108774 BU857695 AI203290 BQ440799 AL534588 CK000151 BE745889 BQ777189 
    BG753420 BQ681589 BQ927101 BQ212079 AI889491 CA488198 CR603908 BG059624 
    BQ948016 CA397702 AW081821 AU134860 BU624065 BM551760 BQ647460 BX445332 
    BQ933560 CD367718 BQ686108 BE742154 BM826021 H13874 BE902429 BQ948097 
    T27614 CD516607 CB126469 BE385948 BU180391 BM724447 BQ684037 BQ927391 
    T75500 BU628579 BQ933470 AA400974 AI087023 AI834323 BQ672706 CR623720 
    CD674046 BG753260 CA422162 BM829550 CD672793 D52428 BE748144 BQ068654 
    BQ433650 BE383355 BQ881616 F29440 BM763673 AL552639 AI678682 BM694915 
    CD172220 BQ881063 BM828159 CA405830 BI908804 BQ940951 BX387276 BM836602 
    BU184734 CF131339 BE262618 BM471750 AW262857 BQ929963 BQ878384 BQ949807 
    CB152958 BE739890 BM698878 CF132284 BM824153 BM991542 BM992900 AA526188 
    CR620993 BU956429 BE271717 BE563498 H02237 BU616462 AW273189 AA587475 
    BG478639 AL522201 BM794411 BG424394 BQ690734 BF109764 BQ644297 CA439106 
    BQ690342 BG765110 CB160302 BU628745 CA443891 M13451 CA426216 BM969918 
    BU553733 C02919 BQ688085 BE901291 BG762032 BM836974 BG763795 AI160452 
    BQ678303 CB266803 BG675574 BQ685002 CB178046 BG285874 BM045699 BM794989 
    BM830579 BM925876 BQ654047 AI621195 BM786304 BG325464 CB125633 AL531078 
    BM826422 BI005413 AW069622 AW009778 BG469842 AL554772 BF312035 AL549051 
    BQ957405 BQ688359 BU628628 BG778930 BG332511 BE875339 BU542826 BG059842 
    BG252839 BG765761 AI887656 BG679422 BQ927100 BG760871 BM046205 BG753234 
    AI351076 BU686339 BG821153 BQ677261 X03444 BU501368 BX417896 BQ574327 
    BF971675 BI199297 BF182890 AW337161 BG419672 BG422962 BI256920 BQ685344 
    CF132413 BQ644692 AA813351 BG765753 BE279371 BG325483 CB988470 BX402657 
    AV706952 AA295223 BQ683129 BG822820 BU166286 BU168573 CB991781 BQ956330 
    BU168440 BM051110 CN480537 AL571219 M13452 C06377 BE279601 BQ923306 
    BU190484 BG331943 AA378253 AL518509 CB068026 BG254166 BG767841 BQ778291 
    BQ890187 BG821491 BF685734 BG830928 AW276349 BM836975 CF132488 BQ690743 
    AL573845 AI610595 AA149923 AL578718 BM738523 BG330864 AA308619 BM752487 
    CA436127 BG574083 AI803823 AI972489 BQ674014 BG030924 BG325782 BF340092 
    BF237579 CD620845 BG775502 BG761146 BE907248 BX363096 BU196343 BG823726 
    X03445 CB989750 BG764701 BM811334 BG179703 BM834841 R23628 CA405735 
    BG769289 BG770718 CD364969 BI764681 BU687241 BE313578 AL572643 AI628530 
    BX431718 BQ644427 AU130227 AI128506 BQ424735 BF684740 BM453529 AA977422 
    BE278241 BU500137 AL545550 BG753208 BI518325 BG830718 AA369645 CO249777 
    BI860099 BM452159 BE894830 AA284719 BQ653894 BE315456 BI117461 BQ928695 
    BF569243 BQ648990 BQ717327 BX438733 AL547846 BU191229 BG338007 BG490935 
    BG471885 BX339588 BM708709 BQ945712 BF315977 CN481523 BI258988 BF684815 
    AL556469 BG715859 BG339769 BU624914 BM044996 BF026990 CN480332 BG478720 
    BQ671126 BQ691083 BG576355 BF313290 BG339166 BG476664 CF594258 R70195 
    BQ073422 BI828827 BG482493 BG420234 BG763391 AK056143 AK057997 BQ948165 
    BU191356 BX374150 BG421115 CA394278 BI335070 BQ651611 BG775098 AI139122 
    BE869491 BU543021 BQ959607 BG766968 BI561331 AL524230 BI869499 BQ689345 
    BE747280 BE384082 BI836090 CD620848 BM787271 CA775841 BM797110 AL542279 
    BU687230 AI143136 BG036147 BG748282 BG829872 BM756617 AL121004 BQ691671 
    BG831124 BM828731 BU535419 BU160013 BQ686473 BX446735 BQ101136 BM836695 
    BE904182 AI660248 BG489943 CB126191 AI911853 BU527169 H28203 BU743029 
    BG331020 AW192659 BF346269 BE208049 CB044372 BG824642 BG824058 BG749818 
    BU150249 BI160620 BE741891 BE748559 BQ681591 BF568266 BE206167 BQ929642 
    BM794449 BU151484 BU168332 BG768469 BF195650 BF125344 BU848633 AL544580 
    BG718639 AL516552 BE613565 BQ668508 BE389011 BQ644678 BU168886 BC033088 
    BE875245 CB529720 BQ962919 AI141801 BM849796 AL602320 BG420321 BG480676 
    BU527956 BM983786 BM751510 BQ016572 BU189649 BQ575684 BI457568 CB142415 
    BV183364 BE732517 CD109869 BM673415 BG119733 BQ643825 CB148668 AI811966 
    BG167665 AU141882 BF220083 BG118830 BG697410 BG437494 BQ923760 BE869002 
    BM979204 AA316324 AU076972 CD620856 BQ957104 AW261861 AA923529 BG114602 
    BQ654338 BU527692 CB113555 CB992188 BE272747 BF315448 AI570879 BI757824 
    BU839194 BM979501 D55092 BI093632 BE543659 BE873717 BX439157 BQ691870 
    BG058732 BQ774420 BM830050 AL578163 BF344015 BG768657 BG747681 BM903701 
    BM049294 BE378649 BM083787 CB137384 BI333937 AU155680 BE563153 BF971926 
    CB132076 AK026584 BF684539 AL555723 BF339124 BI091194 AL523449 BG769923 
    BG291103 BG761416 AL563933 BI670148 BQ019800 AA961132 BQ020354 BM790954 
    BE391086 BE743559 BG983190 CB139571 BQ939435 BU541228 BM046936 BG327955 
    BG822844 AL046826 AL523901 CD110032 BM827929 BI561605 CB528799 BP381495 
    CB993013 BG752668 BG423813 AA594368 AI283337 BM045634 BG033408 BG121589 
    BE379165 BQ685949 BQ100835 AL526129 CB991626 CF131722 BQ684741 BG248222 
    AI149988 CB140341 BU159070 BM042309 BG324908 BU186042 BE408471 BG751005 
    BG709343 BE382597 AI080023 BM839587 BQ015921 BG679159 BG747466 BE895174 
    BU543896 BG822592 BQ955869 BE544170 AI273432 BM980305 T81571 BQ677887 
    BG769043 BU500850 BM914475 BM677718 CA426153 BQ005576 CB125711 BQ691807 
    BE735390 AL551236 BX483921 CB529541 BQ954730 CB959646 BM796899 BM468449 
    BG762386 AW732517 BE302861 BU161741 CA395877 BG701671 BM549207 BF035195 
    CB149700 CA435633 BE745967 BQ019712 BQ677941 CA307468 BG421218 CA312066 
    AI701956 BQ926244 BG423931 AW002334 AA158615 BG325266 BG326104 BE878245 
    BQ220110 BQ575529 BG330751 BE910646 BE747580 AL547147 AI127934 BE615177 
    BI517605 BG437389 AW178695 CB960729 BQ719211 CB124660 BU541965 BG032016 
    BM046745 BU168871 BF338396 CB044373 BI858736 CD365197 BG386274 BG326189 
    AA777180 BE313539 CB854404 BU177151 BG747163 BQ938571 BQ722541 BG420208 
    BE879196 BE735784 CB147125 BQ883991 CB124219 CB269177 BM715431 AU134390 
    BE747241 BF195056 CB110972 BI084425 BI161336 BI488568 AU155238 BX324460 
    BM838040 BI195851 CN484185 BG766180 BG281238 AA534337 BF032323 CA424001 
    BG771075 AU135513 BG336698 BG715914 AA128688 BU180120 AI365669 BG327047 
    BE880395 BM739063 BE514928 BM042986 BU682915 BI762355 BM837075 BE392380 
    BQ004604 BG761401 BQ883824 BM552469 AW238797 BM854120 BU167392 CA843788 
    BG485706 BM714386 BM809201 BE727131 BI196746 BG028989 CD367371 BE906251 
    BM837520 BF570218 BU174269 AI660822 BG821602 BG829459 BQ380651 BG831768 
    BI836040 BG740834 BF686540 BQ922458 AL044139 AW613798 BI257379 BU856149 
    BI160530 AI608872 CB242469 BQ644045 BE258158 AI002109 BG751672 BE393013 
    BM757284 BE293149 BM916889 BE741154 BQ679672 BI523733 BM836898 CF132303 
    BG760704 BE743136 BQ957768 BE884805 BQ686202 BI196114 AI803888 BU553893 
    BG765359 BI011278 BE326686 AU133803 BQ939969 BM982364 BG770312 BG763878 
    BG422905 CD251075 BX324458 BU752027 BQ948014 AW080595 BI837827 BE746752 
    BI258282 N20553 BG385672 BE741601 BQ669204 BQ230223 BG283068 BU732343 
    BG831153 CF131250 BE301840 AI911694 CD243124 BQ877795 BU741700 BI457328 
    BQ446060 BU685425 AA295817 CA421611 BQ688263 CO247666 BG121757 BM011159 
    BQ672651 AL552807 BU541062 BE409161 BM837840 BG762902 BG769301 AA360945 
    BG331089 BG475711 BE563602 CA406573 BQ901151 BM790409 BE877967 BU162545 
    AA371687 AL570318 CD620852 AI367579 T54841 BG775698 AI002393 AA622917 
    AI078093 CB988601 AA113797 BU539493 BG058668 BI548804 AV727946 BQ673779 
    BG395233 BG831948 CA776056 AI689049 CB149358 BF569754 AI865851 AA330127 
    BQ936597 AA149990 CD620858 BF688836 BE728316 AW513792 BE391130 H67894 
    BG474370 BU166961 AL522881 BG681960 BI195349 BE272594 N69363 BE615359 
    BG280875 AI750943 AI962000 AL522200 AL562619 BQ927617 BX472851 BF343415 
    BM091017 BM047823 BM669664 H13831 BG422657 BI914614 AI569069 AI968643 
    BG334791 AU127276 AI689407 AL522880 N24964 BM685365 BM797867 CB149165 
    AA553831 AL516551 AA009972 CA406131 BF688357 AU155563 AI799623 BX445331 
    BG722919 BI457571 R70345 BQ231547 BM819595 BQ942305 BX332013 BE221253 
    AA604635 W92262 BG399090 BQ687599 AI752735 BG724241 BE736864 H75789 
    AA862024 BE247446 BG769111 BM042425 AI383099 CA417412 BG280950 BQ940222 
    BE385883 AW732434 AA878443 AL547111 BM821790 BI012272 BU731721 BG721158 
    AA132691 BM969323 BG118970 BF933395 AI932904 AA063576 N93385 BE278685 
    AI983927 AA160013 AL562283 BQ888614 BU145839 AI742283 BI161044 BX339306 
    BM044320 BF027607 BM790469 BG681083 AA506148 AU147255 AI620814 BG762113 
    AA662074 AI859525 AI874369 BM718590 N92467 AI302749 BX358628 BG760884 
    BF718703 BG252662 AU154997 BI254492 T48331 CB126194 AW195724 BU072027 
    AW068718 BE391595 AL529583 BF125608 BQ888598 BU731900 BF934896 BQ007896 
    AA042919 BX324459 CD620846 CB148906 BE563350 BG281670 AI752311 BG339062 
    BI195287 BF126034 BG339598 AA157840 BF026811 BG770479 AA961563 BF344104 
    H26367 BQ073404 T81986 BI834953 BE794372 BE311748 BX457581 BM152459 
    CD172519 CD620851 BE563156 BM828722 BP432197 AW001321 BQ677709 CB137628 
    AU144613 AW274619 BE886307 AW008070 N34785 BI192854 CA435612 AU280539 
    BG425291 BQ424221 AA375663 AW025435 AV706605 AA496997 BE728293 BE271380 
    AA476846 AU156089 AA552369 BE378614 AA558592 AL577420 AI768259 BE616110 
    BM017883 BG911567 BX324457 BX353228 R79543 CF141899 BM751262 AL562800 
    BE622171 AA314170 AA165697 AI686713 AW768658 CB243655 BE731391 AA897393 
    CA943166 BG761813 BM313273 BG335605 R54732 BG722926 AI752112 W47417 
    BG473943 BU539276 BG829954 BG764524 AI920930 BE391554 H44572 BQ878187 
    BE388403 BM048195 AU154857 AW188455 BE387523 AI239414 H94408 AA079780 
    AA617648 BE410725 BE278077 BI005411 BE615331 BM910093 BM755516 BX351462 
    BG331255 H94316 BI818292 BX336354 AW950189 AI872233 CB125684 BM809185 
    AA156574 W47612 AI635790 BQ232906 BG437951 H27754 BG761832 R70346 
    CA868207 BF132595 BU529070 BE788623 BI561802 BM755705 AA052896 BM854442 
    T86435 R47924 D55055 BI906271 BI869975 R70196 AL515888 AU158825 
    AA977289 BE388429 AU146056 BF476008 BQ962207 AA158024 BG423592 BG118250 
    AA662108 CB132124 BG489801 W73498 BF921574 AA578831 AU144386 BM837740 
    AU155092 BE390415 AW245786 AA042907 AA079752 BG682614 CD620840 BG475449 
    BU157091 AA158307 BE868068 AI023845 AW339207 H27813 AI914733 BI524593 
    AI039427 BM013736 R70356 BE301243 BE910562 BU540666 AI570910 BG118358 
    R69429 AU159099 BX363438 BM923095 AA633170 AI814696 AA011039 BQ721175 
    BF760521 BE300536 AA709266 AL530808 BG339490 BQ073767 AI834329 AA158419 
    AA853575 BP873526 AL575869 AU148271 AA971500 BI010447 AI587237 BM050583 
    AA630395 BU950894 BM836936 T80894 BM091322 BQ678076 AU144430 AL523448 
    W35219 AA009971 AA633173 AA157108 AA599490 BG250864 AA076386 BE614959 
    AW732435 BE272774 BU177828 BI911119 BQ015908 BM836955 AA011106 BG938688 
    AI813616 AA828222 BE262912 D11851 BG569951 BU620289 BX344864 AA160300 
    AI445377 AW082754 BG622189 BM791818 AA284896 AW630015 AA554695 BI042520 
    CA487725 BI160790 AI189413 BE734979 AA059450 BF350417 N29265 AA968781 
    AA035706 BU732422 BG822443 T55218 AI571606 BX342399 AA160361 AW197992 
    AU148092 T75547 R79542 AI972393 AL530807 R55455 R50544 BI457534 
    AI802580 AA158420 AA632393 CD365536 R74021 AL047709 AI627213 AL542278 
    AW450106 BG315015 AI200474 AU147867 BQ929000 BG119605 BX360403 AA160236 
    BG123007 CF131321 BX360887 F34553 AW304365 AA535854 BE271599 AI498237 
    BQ940453 AI683440 AA158616 BE391922 H22218 AA114114 AW303859 AU147366 
    AA329547 BQ892729 AA489582 AA837841 AA729809 CA842206 AA076538 H44571 
    BX494181 CD620838 AL529582 BE388037 AA397856 BU188357 AA838130 AA595926 
    AA057544 AA307416 AU147605 AA158524 BE736552 AI962044 AA523096 R70355 
    AU159433 AA160091 AU145732 AI972217 BU553618 BE868447 BE296200 AL574874 
    T80823 AL562322 BG762812 BQ675976 T29540 AU147517 AA128502 AU158982 
    AI254230 AI126259 BE878227 BI159839 CD245072 H28249 T68743 BU173578 
    AI814093 CD620843 AI192456 BM046285 AI699001 BG747558 BF848800 BE149587 
    AL573392 AA771920 CB995432 AA852297 H22169 BU185718 R54884 BQ327212 
    BQ682860 BG681973 BF887070 BG326581 H67939 BQ878436 R62804 AA565233 
    AI869188 BQ359465 W16593 H75788 BG326598 BG682593 BI045975 T48330 
    BU185349 CO245329 R88141 T68810 BQ952634 AA157897 AL570656 BI868896 
    BF835771 AA605150 AA578820 AI352377 AU152381 BQ957612 AI090900 AI191123 
    AA158412 AU146648 BF884684 R48032 AI951206 BE966291 AI934224 BF435939 
    BF679852 AL518508 AU145481 BM313214 BI005405 BU509599 BU509576 AA723126 
    CA868441 R62854 BG151520 AA132784 T86524 BG775784 BE967003 BI085034 
    R50641 BG489887 BM790471 AL565579 AA662257 AL575981 N91391 BF343098 
    BG436809 AA401138 BF570477 BQ073505 AA150322 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LMNA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                            -                                   -                                 
    SP2:                                            -                                   -           -                     
    SP3:                                            -                                                                     
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for LMNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LMNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGGCT
    LMNA Expression
    About this image


    LMNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Primary Oocyte Primary Follicle
             Oviduct
             Secondary follicles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    LMNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMNA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594444

    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is
    prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions,
    where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and
    disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of
    ZMPSTE24/FACE1 in response to oxidative stress

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
    QuantiTect SYBR Green Assays in human, mouse, rat LMNA
    QuantiFast Probe-based Assays in human, mouse, rat LMNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LMNA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmna1 , 5 lamin A1, 5 90.15(n)1
    96.53(a)1
      3 (38.84 cM)5
    169051  NM_001002011.31  NP_001002011.21 
     884811485 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    47(a)
    many ↔ many
    10(10954013-10971823)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    67(a)
    57(a)
    1 ↔ many
    1 ↔ many
    GL344336.1(6444-21018)
    2(41214999-41216574)
    African clawed frog
    (Xenopus laevis)
    Amphibia lmna-A2 lamin A/C 76.67(n)    X06345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmna2 lamin A 76.11(n)   195815  AF397016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LamC3 nuclear envelope reassembly 37(a)
    (best of 2)
      51B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea lmn-13 Intermediate filament proteins (2
    domains)
    30(a)
    (best of 5)
      I(8771116-8773244)   --


    ENSEMBL Gene Tree for LMNA (if available)
    TreeFam Gene Tree for LMNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LMNA gene
    DES2  NEFM2  LMNB12  VIM2  INA2  LMNB22  NEFH2  GFAP2  
    PRPH2  
    5 SIMAP similar genes for LMNA using alignment to 5 protein entries:     LMNA_HUMAN (see all proteins):
    LMNB1    LMNB2    VIM    KRT5    keratin

    Find genes that share paralogs with LMNA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LMNA (see all 1431)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583275331,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585673(+) CCACCC/G/TGCATC 11 R G C nc-transcript-variantmis10--------
    rs289289031,2,,4
    CCardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH)4 pathogenic1162585769(+) AGAACC/GCAGGG 7 P A nc-transcript-variantmis1 ese30--------
    rs289289001,2,,4
    CLipodystrophy, familial partial, 2 (FPLD2)4 pathogenic1162585778(+) GGCTGC/GGCCTT 7 R G nc-transcript-variantmis1 ese30--------
    rs577937371,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585788(+) TCGCAA/G/TCACCG 11 N S I nc-transcript-variantmis10--------
    rs289330901,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162585854(+) CGAGCG/TCGGGG 7 R L nc-transcript-variantmis10--------
    rs608642301,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 pathogenic1162601334(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs606522251,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601355(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs589126331,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601364(+) GAACTC/TCAAGG 10 S F mis10--------
    rs603102641,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601369(+) CCAAGA/GAGGCC 10 K E mis10--------
    rs289330931,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162601417(+) AGGGCA/GAGCTG 10 K E mis10--------

    HapMap Linkage Disequilibrium report for LMNA (156052364 - 156109880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMNA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    Human Gene Mutation Database (HGMD): LMNA
    Locus Specific Mutation Databases (LSDB): LMNA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMNA
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 150330   
    OMIM disorders: 181350  115200  151660  605588  613205  159001  248370  176670  275210  610140  212112  
    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
  • Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Emery-Dreifuss muscular dystrophy 3, autosomal recessive (EDMD3) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, dilated 1A (CMD1A) [MIM:115200]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lipodystrophy, familial partial, 2 (FPLD2) [MIM:151660]: A disorder characterized by the loss of
    subcutaneous adipose tissue in the lower parts of the body (limbs, buttocks, trunk). It is accompanied by an
    accumulation of adipose tissue in the face and neck causing a double chin, fat neck, or cushingoid appearance.
    Adipose tissue may also accumulate in the axillae, back, labia majora, and intraabdominal region. Affected
    patients are insulin-resistant and may develop glucose intolerance and diabetes mellitus after age 20 years,
    hypertriglyceridemia, and low levels of high density lipoprotein cholesterol. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Limb-girdle muscular dystrophy 1B (LGMD1B) [MIM:159001]: An autosomal dominant degenerative myopathy with
    age-related atrioventricular cardiac conduction disturbances, dilated cardiomyopathy, and the absence of early
    contractures. Characterized by slowly progressive skeletal muscle weakness of the hip and shoulder girdles.
    Muscle biopsy shows mild dystrophic changes. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth
    disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy,
    initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is
    classified in two main groups on the basis of electrophysiologic properties and histopathology: primary
    peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral
    axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in
    the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and
    progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hutchinson-Gilford progeria syndrome (HGPS) [MIM:176670]: Rare genetic disorder characterized by features
    reminiscent of marked premature aging. Note=The disease is caused by mutations affecting the gene represented in
    this entry. HGPS is caused by the toxic accumulation of a truncated form of lamin-A/C. This mutant protein,
    called progerin (isoform 6), acts to deregulate mitosis and DNA damage signaling, leading to premature cell death
    and senescence. The mutant form is mainly generated by a silent or missense mutation at codon 608 of prelamin A
    that causes activation of a cryptic splice donor site, resulting in production of isoform 6 with a deletion of 50
    amino acids near the C terminus. Progerin lacks the conserved ZMPSTE24/FACE1 cleavage site and therefore remains
    permanently farnesylated. Thus, although it can enter the nucleus and associate with the nuclear envelope, it
    cannot incorporate normally into the nuclear lamina (PubMed:12714972)
  • Cardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH) [MIM:212112]: A disorder
    characterized by the association of genital anomalies, hypergonadotropic hypogonadism and dilated cardiomyopathy.
    Patients can present other variable clinical manifestations including mental retardation, skeletal anomalies,
    scleroderma-like skin, graying and thinning of hair, osteoporosis. Dilated cardiomyopathy is characterized by
    ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mandibuloacral dysplasia with type A lipodystrophy (MADA) [MIM:248370]: A disorder characterized by
    mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid
    appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with loss of
    subcutaneous fat from the extremities. Adipose tissue in the face, neck and trunk is normal or increased.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lethal tight skin contracture syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by
    intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and
    epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent
    eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia,
    multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first
    week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Heart-hand syndrome Slovenian type (HHS-Slovenian) [MIM:610140]: Heart-hand syndrome (HHS) is a
    clinically and genetically heterogeneous disorder characterized by the co-occurrence of a congenital cardiac
    disease and limb malformations. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Muscular dystrophy congenital LMNA-related (MDCL) [MIM:613205]: A form of congenital muscular dystrophy.
    Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with
    joint contractures. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in LMNA may cause a late-onset cardiocutaneous progeria syndrome characterized by cutaneous
    manifestations of aging appearing in the third decade of life, cardiac valve calcification and dysfunction,
    prominent atherosclerosis, and cardiomyopathy, leading to death on average in the fourth decade

  • Selected diseases for LMNA (see all 51):    
    About MalaCards
    laminopathy type decaudain-vigouroux    lmna-related cardiocutaneous progeria syndrome    lipodystrophy, familial partial, type 2    progeria-associated arthropathy
    familial partial lipodystrophy, kobberling type    cardiomyopathy, dilated, 1a    lmna-related emery-dreifuss muscular dystrophy, autosomal    dilated cardiomyopathy with quadriceps myopathy
    progeria    emery-dreifuss muscular dystrophy    autosomal codominant severe lipodystrophic laminopathy    atypical werner syndrome
    charcot-marie-tooth neuropathy type 2b1    congenital muscular dystrophy    lmna-related muscle diseases    mandibuloacral dysplasia
    familial partial lipodystrophy    charcot-marie-tooth disease type 2b1    mandibuloacral dysplasia with type a lipodystrophy    emery-dreifuss muscular dystrophy 2, ad

    9 diseases from the University of Copenhagen DISEASES database for LMNA:
    Progeria     Lipodystrophy     Dilated cardiomyopathy     Myopathy
    Neuropathy     Congenital heart block     Werner syndrome     Acanthosis nigricans
    Genetic disorder

    Find genes that share disorders with LMNA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LMNA gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, familial partial 97.8 88 12015247 (3), 11397881 (2), 18364375 (2), 19622949 (2) (see all 63)
    progeria 97 77 15479179 (2), 17076270 (2), 16671095 (2), 17469202 (2) (see all 59)
    muscular dystrophy emery-dreifuss 96.5 48 19589462 (2), 16697197 (2), 12685553 (1), 20225280 (1) (see all 41)
    emery-dreifuss muscular dystrophy, autosomal dominant 96.4 21 11532159 (1), 10587585 (1), 11102973 (1), 15639119 (1) (see all 19)
    lgmd1b 95.4 28 10814726 (4), 15678000 (3), 19070492 (2), 15668447 (1) (see all 15)
    mandibuloacral dysplasia 95.3 25 16278265 (2), 16046620 (1), 16364671 (1), 15843404 (1) (see all 16)
    partial lipodystrophy 93.2 32 15817509 (1), 11102973 (1), 12524233 (1), 15773753 (1) (see all 26)
    lipodystrophy 90 59 18077842 (3), 11078466 (2), 12788894 (2), 12844477 (2) (see all 37)
    acroosteolysis 86.4 4 16278265 (1), 17848409 (1), 18554282 (1)
    lipodystrophy, congenital generalized 85.4 4 19169477 (1), 19494770 (1), 14516935 (1)

    GeneTests: LMNA
    GeneReviews: LMNA
    Genetic Association Database (GAD): LMNA
    Human Genome Epidemiology (HuGE) Navigator: LMNA (37 documents)

    Export disorders for LMNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMNA gene, integrated from 10 sources (see all 818):
    (articles sorted by number of sources associating them with LMNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. (PubMed id 12920062)1, 2, 4, 9 Sebillon P.... Komajda M. (J. Med. Genet. 2003)
    2. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. (PubMed id 15219508)1, 2, 4, 9 Hermida-Prieto M....Crespo-Leiro M. (Am. J. Cardiol. 2004)
    3. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). (PubMed id 12768443)1, 2, 9 Cao H. and Hegele R.A. (J. Hum. Genet. 2003)
    4. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. (PubMed id 17327460)1, 4, 9 Owen K.R....McCarthy M.I. (Diabetes 2007)
    5. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (PubMed id 18585512)1, 4, 9 Parks S.B....Hershberger R.E. (Am. Heart J. 2008)
    6. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. (PubMed id 11897440)1, 2, 9 Arbustini E.... Tavazzi L. (J. Am. Coll. Cardiol. 2002)
    7. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. (PubMed id 17327461)1, 4, 9 Mesa J.L....Barroso I. (Diabetes 2007)
    8. Variation in the lamin A/C gene: associations with metabolic syndrome. (PubMed id 15205219)1, 4, 9 Steinle N.I....Shuldiner A.R. (Arterioscler. Thromb. Vasc. Biol. 2004)
    9. LMNA mutations in atypical Werner's syndrome. (PubMed id 12927431)1, 2, 9 Chen L.... Oshima J. (Lancet 2003)
    10. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. (PubMed id 12628721)1, 2, 9 Taylor M.R.G.... Mestroni L. (J. Am. Coll. Cardiol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4000 HGNC: 6636 AceView: LMNA Ensembl:ENSG00000160789 euGenes: HUgn4000
    ECgene: LMNA Kegg: 4000 H-InvDB: LMNA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LMNA Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for LMNA Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LMNA[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LMNA gene:
    Search GeneIP for patents involving LMNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    (lamin A/C)

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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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