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LMNA Gene

protein-coding   GIFtS: 75
GCID: GC01P156053

Lamin A/C

(Previous names: cardiomyopathy, dilated 1A (autosomal dominant), limb girdle...)
(Previous symbols: LMN1, CMD1A, LGMD1B, PRO1, LMNL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lamin A/C1 2     70 KDa Lamin2
LMN11 2 3 5     CDCD12
CMD1A1 2 5     CDDC2
LGMD1B1 2 5     CMT2B12
LMNL11 2     FPL2
PRO11 2     FPLD2
Lamin A/C-Like 11 2     IDC2
EMD22 5     LDP12
FPLD22 5     LFP2
HGPS2 5     LMNC2
Cardiomyopathy, Dilated 1A (Autosomal Dominant)1     lamin2
Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant)1     prelamin-A/C2
Progeria 1 (Hutchinson-Gilford Type)1     Renal Carcinoma Antigen NY-REN-322

External Ids:    HGNC: 66361   Entrez Gene: 40002   Ensembl: ENSG000001607897   OMIM: 1503305   UniProtKB: P025453   
ORGUL members:         

Export aliases for LMNA gene to outside databases

Previous GC identifers: GC01P153921 GC01P151817 GC01P152830 GC01P153301 GC01P152897 GC01P154318 GC01P127446


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMNA Gene:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.
The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina
matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be
involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A
and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy,
dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. (provided by
RefSeq, Apr 2012)

GeneCards Summary for LMNA Gene:
LMNA (lamin A/C) is a protein-coding gene. Diseases associated with LMNA include progeria, and charcot-marie-tooth neuropathy type 2b1. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is DES.

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
maintain the volume and strength of skeletal muscle and bone
Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
senescence

Gene Wiki entry for LMNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMNA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMNA promoter sequence
   Search Chromatin IP Primers for LMNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

LMNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156053:  view genomic region     (about GC identifiers)

Start:
156,052,364 bp from pter      End:
156,109,880 bp from pter
Size:
57,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545 (See protein sequence)
Recommended Name: Prelamin-A/C precursor  
Size: 664 amino acids; 74139 Da
Subunit: Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1
and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43 (By similarity). Proteolytically processed
isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP; may
regulate MLIP localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability.
Interacts with SUV39H1; the interaction increases stability of SUV39H1
Miscellaneous: There are three types of lamins in human cells: A, B, and C
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Sequence caution: Sequence=CAA27173.1; Type=Frameshift; Positions=582;
Selected PDB 3D structures from and Proteopedia for LMNA (see all 9):
1IFR (3D)        1IVT (3D)        1X8Y (3D)        2XV5 (3D)        2YPT (3D)        3GEF (3D)    
Secondary accessions: B4DI32 D3DVB0 D6RAQ3 E7EUI9 P02546 Q5I6Y4 Q5I6Y6 Q5TCJ2 Q5TCJ3 Q6UYC3
Q969I8 Q96JA2
Alternative splicing: 6 isoforms:  P02545-1   P02545-2   P02545-3   P02545-4   P02545-5   P02545-6   (Disease-associated isoform. Polymorphism at codon 608 results in activation of a cryptic splice donor site within exon 11, resulting in a truncated protein product that lacks the site for endoproteolytic cleavage)

Explore the universe of human proteins at neXtProt for LMNA: NX_P02545

Explore proteomics data for LMNA at MOPED

Post-translational modifications: 

  • Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in
    regulating lamin associations1
  • Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The
    prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the
    last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15
    C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these
    blocks cleavage1
  • Sumoylation is necessary for the localization to the nuclear envelope1
  • Farnesylation of prelamin-A/C facilitates nuclear envelope targeting1
  • Ubiquitination2 at Lys78, Lys108, Lys135, Lys144, Lys171, Lys181, Lys201, Lys208, Lys265, Lys270,
                                 Lys311, Lys378, Lys470, Lys486
  • Modification sites at PhosphoSitePlus

  • See LMNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001244303.1  NP_001269553.1  NP_001269554.1  NP_001269555.1  NP_005563.1  NP_733821.1  NP_733822.1  

    ENSEMBL proteins: 
     ENSP00000357284   ENSP00000357283   ENSP00000357282   ENSP00000395597   ENSP00000424518  
     ENSP00000357280   ENSP00000426535   ENSP00000421821   ENSP00000424977   ENSP00000292304  
     ENSP00000355292   ENSP00000376164  
    Reactome Protein details: P02545

    LMNA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for LMNA
    OriGene Protein Over-expression Lysate for LMNA
    OriGene MassSpec for LMNA
    OriGene Custom Protein Services for LMNA
    GenScript Custom Purified and Recombinant Proteins Services for LMNA
    Novus Biologicals LMNA Protein
    Novus Biologicals LMNA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for LMNA
    Cloud-Clone Corp. Proteins for LMNA

    LMNA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNA  (lamin A/C)
    OriGene Antibodies for LMNA
    OriGene Custom Antibody Services for LMNA
    Novus Biologicals LMNA Antibodies
    Abcam antibodies for LMNA (Q6UYC3, P20700, P02545)
    Cloud-Clone Corp. Antibodies for LMNA
    ThermoFisher Antibody for LMNA
    LSBio Antibodies in human, mouse, rat for LMNA

    LMNA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMNA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMNA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMNA
    Cloud-Clone Corp. CLIAs for LMNA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF5: Intermediate filaments type V, lamins

    3 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry P02545

    ProtoNet protein and cluster: P02545

    2 Blocks protein domains:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Similarity: Belongs to the intermediate filament family


    LMNA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMNA_HUMAN, P02545
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
    nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
    chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
    nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development
    of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for
    osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to
    maintain the volume and strength of skeletal muscle and bone
    Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
    damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
    senescence

         Genatlas biochemistry entry for LMNA:
    lamin,types A and C,common gene,alternatively spliced isoforms

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS3453101
    GO:0005515protein binding IPI10381623
         
    LMNA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LMNA:
     Increased S DNA content  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 16 alleles(MGI details for Lmna) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    LMNA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LMNA: Lmnatm6Lgf Lmnatm1Stw Lmnatm4Lgf Lmnatm5Lgf Lmnatm1Lgf Lmnatm2Lgf

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMNA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMNA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMNA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMNA

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMNA:
    hsa-mir-615-3p (MIRT040169), hsa-mir-296-3p (MIRT038445), hsa-let-7a-5p (MIRT052409), hsa-mir-340-5p (MIRT019532), hsa-mir-124-3p (MIRT022394), hsa-mir-9-5p (MIRT021388), hsa-let-7e-5p (MIRT051592)

    Block miRNA regulation of human, mouse, rat LMNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMNA

    Clone
    Products:
         
    OriGene clones in human, mouse for LMNA (see all 18)
    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    Sino Biological Human cDNA Clone for LMNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMNA
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMNA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMNA_HUMAN, P02545: Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Note=Farnesylation of
    prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the
    farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for
    proper localization of non-farnesylated prelamin-A/C
    LMNA_HUMAN, P02545: Isoform C: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS3453101
    GO:0005638lamin filament TAS10080180
    GO:0005652nuclear lamina TAS8344919
    GO:0005654nucleoplasm TAS--

    LMNA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LMNA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44
    Breakdown of the nuclear lamina0.00
    FAS pathway and Stress induction of HSP regulation0.44
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    5Nuclear Envelope Reassembly
    Nuclear Envelope Reassembly
    Initiation of Nuclear Envelope Reformation0.00
    Clearance of Nuclear Envelope Membranes from Chromatin0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LMNA
        Caspase Cascade
    Granzyme Pathway
    Fas Signaling

    3 Cell Signaling Technology (CST) Pathways for LMNA
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for LMNA
        Adipogenesis
    FAS pathway and Stress induction of HSP regulation
    Arrhythmogenic right ventricular cardiomyopathy
    Caspase cascade in apoptosis


    1 Reactome Pathway for LMNA
        XBP1(S) activates chaperone genes

    1 PharmGKB Pathway for LMNA
        Antiarrhythmic Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for LMNA):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy


    LMNA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LMNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LMNA (P025451, 2, 3 ENSP000003572834) via UniProtKB, MINT, STRING, and/or I2D (see all 1002)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI31, 2, 3, ENSP000003854794EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    HIST2H3DQ71DI31, 2, 3EBI-351935,EBI-750650 MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0006997nucleus organization ----

    LMNA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMNA

    Selected Novoseek inferred chemical compound relationships for LMNA gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nelfinavir 23.7 2 14600514 (1), 18344876 (1)
    rosiglitazone 18 2 14510863 (2)
    indinavir 17.1 4 14600514 (1), 16184025 (1), 12844477 (1)
    zinc 14.2 12 16278265 (1), 19494770 (1), 19323649 (1), 15998779 (1) (see all 7)
    retinoic acid 12.4 18 15219855 (3), 10694499 (3), 12844477 (2), 11478838 (1) (see all 8)
    deoxyribonucleic acid 6.22 1 12015247 (1)
    calcium 0.975 2 1467310 (1), 19144047 (1)
    cholesterol 0 4 11136544 (1), 12524233 (1), 17994215 (1), 15205219 (1)
    atp 0 6 1965140 (2), 15892163 (1), 2004657 (1)
    lipid 0 3 20130076 (2), 16181372 (1)



    LMNA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LMNA gene (7 alternative transcripts): 
    NM_001257374.2  NM_001282624.1  NM_001282625.1  NM_001282626.1  NM_005572.3  NM_170707.3  NM_170708.3  

    Unigene Cluster for LMNA:

    Lamin A/C
    Hs.594444  [show with all ESTs]
    Unigene Representative Sequence: NM_170707
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000502751 ENST00000368301(uc001fnf.1) ENST00000495341 ENST00000470835
    ENST00000515711 ENST00000368300(uc001fng.2 uc001fni.2 uc009wro.1 uc001fnk.2)
    ENST00000478063 ENST00000470199 ENST00000469565 ENST00000368299 ENST00000502357
    ENST00000448611(uc010pgz.1) ENST00000515459 ENST00000368297 ENST00000504687
    ENST00000473598 ENST00000515824 ENST00000496738(uc001fnj.2 uc010pha.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat LMNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LMNA
    Predesigned siRNA for gene silencing in human, mouse, rat LMNA
    Clone
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    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
      QuantiTect SYBR Green Assays in human, mouse, rat LMNA
      QuantiFast Probe-based Assays in human, mouse, rat LMNA

    Additional mRNA sequence: 

    AF381029.1 AK026584.1 AK056143.1 AK056191.1 AK057997.1 AK097801.1 AK098128.1 AK122732.1 
    AK130179.1 AK294217.1 AK295390.1 AK309539.1 AY357727.1 AY528714.1 AY847595.1 AY847596.1 
    AY847597.1 BC000511.2 BC003162.1 BC014507.1 BC018863.2 BC033088.1 M13451.1 M13452.1 
    NR_047544.1 NR_047545.1 X03444.1 X03445.1 

    Selected DOTS entries (see all 79):

    DT.100891747  DT.91871177  DT.92469899  DT.95246279  DT.100891714  DT.95294580  DT.100891710  DT.121347135 
    DT.92469913  DT.100891740  DT.100891733  DT.92057489  DT.101986435  DT.121347131  DT.121347084  DT.100891726 
    DT.99987681  DT.95322263  DT.100039687  DT.121347143  DT.121347120  DT.100891698  DT.100891751  DT.320389 

    Selected AceView cDNA sequences (see all 1597):

    CB150408 AL602697 BU528517 BU626255 BG831209 BU190818 BQ689214 BU543235 
    BM913668 CA436010 BM828139 AI654262 BQ219558 BQ215790 CD674183 BU178121 
    BM836839 BM763030 BE311540 AW245428 AU120748 BM837113 CB130594 BM785968 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LMNA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                            -                                   -                                 
    SP2:                                            -                                   -           -                     
    SP3:                                            -                                                                     
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for LMNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LMNA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGGCT
    LMNA Expression
    About this image


    LMNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Primary Oocyte Primary Follicle
             Oviduct
             Secondary follicles
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Dermal Fibroblasts Dorsal Dermis
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    LMNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMNA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594444

    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is
    prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions,
    where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and
    disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of
    ZMPSTE24/FACE1 in response to oxidative stress

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMNA
    QuantiTect SYBR Green Assays in human, mouse, rat LMNA
    QuantiFast Probe-based Assays in human, mouse, rat LMNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LMNA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmna1 , 5 lamin A1, 5 90.15(n)1
    96.53(a)1
      3 (38.84 cM)5
    169051  NM_001002011.31  NP_001002011.21 
     884811485 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    47(a)
    many ↔ many
    10(10954013-10971823)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    67(a)
    57(a)
    1 ↔ many
    1 ↔ many
    GL344336.1(6444-21018)
    2(41214999-41216574)
    African clawed frog
    (Xenopus laevis)
    Amphibia lmna-A2 lamin A/C 76.67(n)    X06345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmna2 lamin A 76.11(n)   195815  AF397016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LamC3 nuclear envelope reassembly 37(a)
    (best of 2)
      51B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea lmn-13 Intermediate filament proteins (2
    domains)
    30(a)
    (best of 5)
      I(8771116-8773244)   --


    ENSEMBL Gene Tree for LMNA (if available)
    TreeFam Gene Tree for LMNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LMNA gene
    DES2  NEFM2  LMNB12  VIM2  INA2  LMNB22  NEFH2  GFAP2  
    PRPH2  
    5 SIMAP similar genes for LMNA using alignment to 5 protein entries:     LMNA_HUMAN (see all proteins):
    LMNB1    LMNB2    VIM    KRT5    keratin

    LMNA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LMNA (see all 1431)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583275331,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585673(+) CCACCC/G/TGCATC 11 R G C nc-transcript-variantmis10--------
    rs289289031,2,,4
    CCardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH)4 pathogenic1162585769(+) AGAACC/GCAGGG 7 P A nc-transcript-variantmis1 ese30--------
    rs289289001,2,,4
    CLipodystrophy, familial partial, 2 (FPLD2)4 pathogenic1162585778(+) GGCTGC/GGCCTT 7 R G nc-transcript-variantmis1 ese30--------
    rs577937371,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 untested1162585788(+) TCGCAA/G/TCACCG 11 N S I nc-transcript-variantmis10--------
    rs289330901,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162585854(+) CGAGCG/TCGGGG 7 R L nc-transcript-variantmis10--------
    rs608642301,2,,4
    CEmery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4 pathogenic1162601334(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs606522251,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601355(+) GGCTCC/G/TGCTGA 16 P R L mis10--------
    rs589126331,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601364(+) GAACTC/TCAAGG 10 S F mis10--------
    rs603102641,2,,4
    CHutchinson-Gilford progeria syndrome (HGPS)4 pathogenic1162601369(+) CCAAGA/GAGGCC 10 K E mis10--------
    rs289330931,2,,4
    CCardiomyopathy, dilated 1A (CMD1A)4 pathogenic1162601417(+) AGGGCA/GAGCTG 10 K E mis10--------

    HapMap Linkage Disequilibrium report for LMNA (156052364 - 156109880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMNA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    Human Gene Mutation Database (HGMD): LMNA
    Locus Specific Mutation Databases (LSDB): LMNA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LMNA
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 150330   
    OMIM disorders: 181350  115200  151660  605588  613205  159001  248370  176670  275210  610140  212112  
    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
  • Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Emery-Dreifuss muscular dystrophy 3, autosomal recessive (EDMD3) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, dilated 1A (CMD1A) [MIM:115200]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lipodystrophy, familial partial, 2 (FPLD2) [MIM:151660]: A disorder characterized by the loss of
    subcutaneous adipose tissue in the lower parts of the body (limbs, buttocks, trunk). It is accompanied by an
    accumulation of adipose tissue in the face and neck causing a double chin, fat neck, or cushingoid appearance.
    Adipose tissue may also accumulate in the axillae, back, labia majora, and intraabdominal region. Affected
    patients are insulin-resistant and may develop glucose intolerance and diabetes mellitus after age 20 years,
    hypertriglyceridemia, and low levels of high density lipoprotein cholesterol. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Limb-girdle muscular dystrophy 1B (LGMD1B) [MIM:159001]: An autosomal dominant degenerative myopathy with
    age-related atrioventricular cardiac conduction disturbances, dilated cardiomyopathy, and the absence of early
    contractures. Characterized by slowly progressive skeletal muscle weakness of the hip and shoulder girdles.
    Muscle biopsy shows mild dystrophic changes. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth
    disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy,
    initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is
    classified in two main groups on the basis of electrophysiologic properties and histopathology: primary
    peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral
    axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in
    the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and
    progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hutchinson-Gilford progeria syndrome (HGPS) [MIM:176670]: Rare genetic disorder characterized by features
    reminiscent of marked premature aging. Note=The disease is caused by mutations affecting the gene represented in
    this entry. HGPS is caused by the toxic accumulation of a truncated form of lamin-A/C. This mutant protein,
    called progerin (isoform 6), acts to deregulate mitosis and DNA damage signaling, leading to premature cell death
    and senescence. The mutant form is mainly generated by a silent or missense mutation at codon 608 of prelamin A
    that causes activation of a cryptic splice donor site, resulting in production of isoform 6 with a deletion of 50
    amino acids near the C terminus. Progerin lacks the conserved ZMPSTE24/FACE1 cleavage site and therefore remains
    permanently farnesylated. Thus, although it can enter the nucleus and associate with the nuclear envelope, it
    cannot incorporate normally into the nuclear lamina (PubMed:12714972)
  • Cardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH) [MIM:212112]: A disorder
    characterized by the association of genital anomalies, hypergonadotropic hypogonadism and dilated cardiomyopathy.
    Patients can present other variable clinical manifestations including mental retardation, skeletal anomalies,
    scleroderma-like skin, graying and thinning of hair, osteoporosis. Dilated cardiomyopathy is characterized by
    ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mandibuloacral dysplasia with type A lipodystrophy (MADA) [MIM:248370]: A disorder characterized by
    mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid
    appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with loss of
    subcutaneous fat from the extremities. Adipose tissue in the face, neck and trunk is normal or increased.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lethal tight skin contracture syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by
    intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and
    epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent
    eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia,
    multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first
    week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Heart-hand syndrome Slovenian type (HHS-Slovenian) [MIM:610140]: Heart-hand syndrome (HHS) is a
    clinically and genetically heterogeneous disorder characterized by the co-occurrence of a congenital cardiac
    disease and limb malformations. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Muscular dystrophy congenital LMNA-related (MDCL) [MIM:613205]: A form of congenital muscular dystrophy.
    Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with
    joint contractures. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=Defects in LMNA may cause a late-onset cardiocutaneous progeria syndrome characterized by cutaneous
    manifestations of aging appearing in the third decade of life, cardiac valve calcification and dysfunction,
    prominent atherosclerosis, and cardiomyopathy, leading to death on average in the fourth decade

  • Selected diseases for LMNA (see all 147):    
    About MalaCards
    progeria    charcot-marie-tooth neuropathy type 2b1    congenital muscular dystrophy    heart-hand syndrome, slovenian type
    lmna-related cardiocutaneous progeria syndrome    lmna-related emery-dreifuss muscular dystrophy, autosomal    progeroid laminopathies    lmna-related dilated cardiomyopathy
    emery-dreifuss muscular dystrophy 3, ar    familial partial lipodystrophy, kobberling type    emery-dreifuss muscular dystrophy    autosomal codominant severe lipodystrophic laminopathy
    mandibuloacral dysplasia    limb-girdle muscular dystrophy, type 1b    laminopathy type decaudain-vigouroux    lipodystrophy, familial partial, type 2
    progeria-associated arthropathy    cardiomyopathy, dilated, 1a    dilated cardiomyopathy with quadriceps myopathy    atypical werner syndrome

    9 diseases from the University of Copenhagen DISEASES database for LMNA:
    Progeria     Lipodystrophy     Dilated cardiomyopathy     Myopathy
    Neuropathy     Congenital heart block     Werner syndrome     Acanthosis nigricans
    Genetic disorder

    LMNA for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for LMNA gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, familial partial 97.8 88 12015247 (3), 11397881 (2), 18364375 (2), 19622949 (2) (see all 63)
    progeria 97 77 15479179 (2), 17076270 (2), 16671095 (2), 17469202 (2) (see all 59)
    muscular dystrophy emery-dreifuss 96.5 48 19589462 (2), 16697197 (2), 12685553 (1), 20225280 (1) (see all 41)
    emery-dreifuss muscular dystrophy, autosomal dominant 96.4 21 11532159 (1), 10587585 (1), 11102973 (1), 15639119 (1) (see all 19)
    lgmd1b 95.4 28 10814726 (4), 15678000 (3), 19070492 (2), 15668447 (1) (see all 15)
    mandibuloacral dysplasia 95.3 25 16278265 (2), 16046620 (1), 16364671 (1), 15843404 (1) (see all 16)
    partial lipodystrophy 93.2 32 15817509 (1), 11102973 (1), 12524233 (1), 15773753 (1) (see all 26)
    lipodystrophy 90 59 18077842 (3), 11078466 (2), 12788894 (2), 12844477 (2) (see all 37)
    acroosteolysis 86.4 4 16278265 (1), 17848409 (1), 18554282 (1)
    lipodystrophy, congenital generalized 85.4 4 19169477 (1), 19494770 (1), 14516935 (1)

    GeneTests: LMNA
    GeneReviews: LMNA
    Genetic Association Database (GAD): LMNA
    Human Genome Epidemiology (HuGE) Navigator: LMNA (37 documents)

    Export disorders for LMNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMNA gene, integrated from 10 sources (see all 818) (see top 10):
    (articles sorted by number of sources associating them with LMNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. (PubMed id 12920062)1, 2, 4, 9 Sebillon P.... Komajda M. (J. Med. Genet. 2003)
    2. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. (PubMed id 15219508)1, 2, 4, 9 Hermida-Prieto M....Crespo-Leiro M. (Am. J. Cardiol. 2004)
    3. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). (PubMed id 12768443)1, 2, 9 Cao H. and Hegele R.A. (J. Hum. Genet. 2003)
    4. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. (PubMed id 17327460)1, 4, 9 Owen K.R....McCarthy M.I. (Diabetes 2007)
    5. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (PubMed id 18585512)1, 4, 9 Parks S.B....Hershberger R.E. (Am. Heart J. 2008)
    6. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. (PubMed id 11897440)1, 2, 9 Arbustini E.... Tavazzi L. (J. Am. Coll. Cardiol. 2002)
    7. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. (PubMed id 17327461)1, 4, 9 Mesa J.L....Barroso I. (Diabetes 2007)
    8. Variation in the lamin A/C gene: associations with metabolic syndrome. (PubMed id 15205219)1, 4, 9 Steinle N.I....Shuldiner A.R. (Arterioscler. Thromb. Vasc. Biol. 2004)
    9. LMNA mutations in atypical Werner's syndrome. (PubMed id 12927431)1, 2, 9 Chen L.... Oshima J. (Lancet 2003)
    10. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. (PubMed id 12628721)1, 2, 9 Taylor M.R.G.... Mestroni L. (J. Am. Coll. Cardiol. 2003)
    11. Novel and recurrent mutations in lamin A/C in patients with Emery- Dreifuss muscular dystrophy. (PubMed id 11503164)1, 2, 9 Brown C.A.... Spence J.E. (Am. J. Med. Genet. 2001)
    12. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. (PubMed id 10655060)1, 2, 9 Shackleton S.... Trembath R.C. (Nat. Genet. 2000)
    13. Mutations in the LMNA gene do not cause axonal CMT in Czech patients. (PubMed id 19424285)1, 4, 9 LassuthovA! P....Seeman P. (J. Hum. Genet. 2009)
    14. Validation of high-resolution DNA melting analysis for mutation scanning of the LMNA gene. (PubMed id 19318026)1, 4, 9 Millat G....Rousson R. (Clin. Biochem. 2009)
    15. Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids. (PubMed id 17994215)1, 4, 9 Duesing K....Gibson F. (Diabetologia 2008)
    16. Collagen expression in fibroblasts with a novel LMNA mutation. (PubMed id 17150192)1, 2, 9 Nguyen D.... Oshima J. (Biochem. Biophys. Res. Commun. 2007)
    17. Mutations of the LMNA gene can mimic autosomal dominant proximal spinal muscular atrophy. (PubMed id 17136397)1, 2, 9 Rudnik-Schoeneborn S.... Zerres K. (Neurogenetics 2007)
    18. Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. (PubMed id 11799477)1, 2, 9 De Sandre-Giovannoli A.... Levy N. (Am. J. Hum. Genet. 2002)
    19. An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese. (PubMed id 12145775)1, 4, 9 Murase Y....Mabuchi H. (Metab. Clin. Exp. 2002)
    20. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). (PubMed id 10814726)1, 2, 9 Muchir A.... Schwartz K. (Hum. Mol. Genet. 2000)
    21. Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation. (PubMed id 19427440)1, 4, 9 Brauch K.M....Olson T.M. (Am. J. Cardiol. 2009)
    22. In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients. (PubMed id 16061563)1, 2, 9 Sylvius N.... Tesson F. (J. Med. Genet. 2005)
    23. Aging syndrome genes and premature coronary artery disease. (PubMed id 16262891)1, 4, 9 Low A.F....MacRae C.A. (BMC Med. Genet. 2005)
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    25. Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians. (PubMed id 11243729)1, 4, 9 Weyer C....Pratley R.E. (Mol. Genet. Metab. 2001)
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    27. Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians. (PubMed id 11440372)1, 4, 9 Wolford J.K....Prochazka M. (Diabetologia 2001)
    28. Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy. (PubMed id 10739764)1, 2, 9 Raffaele di Barletta M.... Toniolo D. (Am. J. Hum. Genet. 2000)
    29. Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (PubMed id 20160190)1, 2, 9 Cowan J....Hershberger R.E. (Circ Cardiovasc Genet 2010)
    30. De novo LMNA mutations cause a new form of congenital muscular dystrophy. (PubMed id 18551513)1, 2, 9 Quijano-Roy S.... Estournet B. (Ann. Neurol. 2008)
    31. Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins. (PubMed id 20079404)1, 2, 9 De Vos W.H.... Van Oostveldt P. (Biochim. Biophys. Acta 2010)
    32. Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. (PubMed id 20458013)1, 2, 9 Ragnauth C.D.... Shanahan C.M. (Circulation 2010)
    33. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4, 9 Fontaine-Bisson B....Morange P.E. (J. Mol. Med. 2010)
    34. Emerin-prelamin A interplay in human fibroblasts. (PubMed id 19323649)1, 2, 9 Capanni C.... Lattanzi G. (Biol. Cell 2009)
    35. Ovarian failure and dilated cardiomyopathy due to a novel lamin mutation. (PubMed id 19283854)1, 2, 9 McPherson E....Giampietro P.F. (Am. J. Med. Genet. A 2009)
    36. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4, 9 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
    37. The role of genetic variation in the lamin a/c gene in the etiology of polycystic ovary syndrome. (PubMed id 19401371)1, 4, 9 Urbanek M....Dunaif A. (J. Clin. Endocrinol. Metab. 2009)
    38. Heart-hand syndrome of Slovenian type: a new kind of laminopathy. (PubMed id 18611980)1, 2, 9 Renou L.... Bonne G. (J. Med. Genet. 2008)
    39. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. (PubMed id 17327437)1, 4, 9 Wegner L....Pedersen O. (Diabetes 2007)
    40. A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia. (PubMed id 15998779)1, 2, 9 Garg A.... Agarwal A.K. (J. Clin. Endocrinol. Metab. 2005)
    41. Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? (PubMed id 15551023)1, 4, 9 van Berlo J.H....Pinto Y.M. (J. Mol. Med. 2005)
    42. Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins. (PubMed id 15476822)1, 2, 9 Strelkov S.V.... Herrmann H. (J. Mol. Biol. 2004)
    43. The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians. (PubMed id 15636422)1, 4, 9 Yiannakouris N....Mantzoros C.S. (J. Endocrinol. Invest. 2004)
    44. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. (PubMed id 12714972)1, 2, 9 Eriksson M.... Collins F.S. (Nature 2003)
    45. Multisystem dystrophy syndrome due to novel missense mutations in the amino-terminal head and alpha-helical rod domains of the lamin A/C gene. (PubMed id 12015247)1, 2, 9 Garg A.... Bowcock A.M. (Am. J. Med. 2002)
    46. Structure of the globular tail of nuclear lamin. (PubMed id 11901143)1, 2, 9 Dhe-Paganon S.... Shoelson S.E. (J. Biol. Chem. 2002)
    47. Lamin A/C mutations with lipodystrophy, cardiac abnormalities, and muscular dystrophy. (PubMed id 12196663)1, 2, 9 van der Kooi A.J.... de Visser M. (Neurology 2002)
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    49. Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. (PubMed id 10739751)1, 2, 9 Speckman R.A.... Bowcock A.M. (Am. J. Hum. Genet. 2000)
    50. Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan- type familial partial lipodystrophy. (PubMed id 10587585)1, 2, 9 Cao H. and Hegele R.A. (Hum. Mol. Genet. 2000)
    51. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 10080180)1, 2, 9 Bonne G.... Schwartz K. (Nat. Genet. 1999)
    52. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. (PubMed id 10580070)1, 2, 9 Fatkin D.... Seidman C.E. (N. Engl. J. Med. 1999)
    53. LMNA-associated cardiocutaneous progeria: an inherited autosomal dominant premature aging syndrome with late onset. (PubMed id 23666920)1, 2 Kane M.S....Michaelis S. (Am. J. Med. Genet. A 2013)
    54. Autosomal recessive Emery-Dreifuss muscular dystrophy caused by a novel mutation (R225Q) in the lamin A/C gene identified by exome sequencing. (PubMed id 22431096)1, 2 Jimenez-Escrig A....Sanchez-Herranz A. (Muscle Nerve 2012)
    55. Novel LMNA mutations in patients with Emery-Dreifuss muscular dystrophy and functional characterization of four LMNA mutations. (PubMed id 20848652)1, 2 Scharner J.... Zammit P.S. (Hum. Mutat. 2011)
    56. Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). (PubMed id 21498514)1, 2 Ahmady E....Burgon P.G. (J. Biol. Chem. 2011)
    57. Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy. (PubMed id 21846512)1, 2 Millat G.... Rousson R. (Eur. J. Med. Genet. 2011)
    58. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    59. LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation. (PubMed id 20501691)1, 4 Wegner L....Vaag A. (J. Clin. Endocrinol. Metab. 2010)
    60. A novel custom resequencing array for dilated cardiomyopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (Genet. Med. 2010)
    61. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. (PubMed id 18848371)1, 4 Cluett C....Melzer D. (Neurobiol. Aging 2010)
    62. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PubMed id 19933576)1, 2 Haque F.... Shackleton S. (J. Biol. Chem. 2010)
    63. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    64. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    65. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    66. The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress. (PubMed id 19220582)1, 2 Verstraeten V.L....Broers J.L. (J. Cell. Mol. Med. 2009)
    67. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4 Schjeide B.M....Bertram L. (Neurogenetics 2009)
    68. LMNA gene mutation search in Polish patients: new features of the heterozygous Arg482Gln mutation phenotype. (PubMed id 19859838)1, 4 Klupa T....Malecki M.T. (Endocrine 2009)
    69. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. (PubMed id 19875404)1, 4 MA...Christiansen M. (Eur. J. Heart Fail. 2009)
    70. A promoter polymorphism of lamin A/C gene is an independent genetic predisposition to arterial stiffness in a Japanese general population (the Tanno and Sobetsu study). (PubMed id 19672032)1, 4 Akasaka H....Shimamoto K. (J. Atheroscler. Thromb. 2009)
    71. Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. (PubMed id 18606848)1, 2 Zhang Y.Q. and Sarge K.D. (J. Cell Biol. 2008)
    72. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    73. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    74. Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. (PubMed id 16117820)1, 4 Liang H....Mabuchi H. (Clin. Endocrinol. (Oxf) 2005)
    75. A new mutation of the lamin A/C gene leading to autosomal dominant axonal neuropathy, muscular dystrophy, cardiac disease, and leuconychia. (PubMed id 14985400)1, 2 Goizet C.... Ferrer X. (J. Med. Genet. 2004)
    76. Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. (PubMed id 15317753)1, 2 Navarro C.L.... Levy N. (Hum. Mol. Genet. 2004)
    77. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    78. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    79. A new clinical condition linked to a novel mutation in lamins A and C with generalized lipoatrophy, insulin-resistant diabetes, disseminated leukomelanodermic papules, liver steatosis, and cardiomyopathy. (PubMed id 12629077)1, 2 Caux F....Christin-Maitre S. (J. Clin. Endocrinol. Metab. 2003)
    80. Lamin a truncation in Hutchinson-Gilford progeria. (PubMed id 12702809)1, 3 De Sandre-Giovannoli A....LAcvy N. (Science 2003)
    81. Apical left ventricular aneurysm without atrio-ventricular block due to a lamin A/C gene mutation. (PubMed id 14675861)1, 2 Forissier J.-F....Komajda M. (Eur. J. Heart Fail. 2003)
    82. Identification of lamin A/C (LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb- girdle muscular dystrophy 1B. (PubMed id 12032588)1, 2 Ki C.-S....Kim J.-W. (J. Hum. Genet. 2002)
    83. Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. (PubMed id 12475961)1, 2 Markiewicz E.... Hutchison C.J. (Mol. Biol. Cell 2002)
    84. The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. (PubMed id 12057196)1, 2 Krimm I.... Zinn-Justin S. (Structure 2002)
    85. Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C. (PubMed id 12075506)1, 2 Novelli G.... Bonne G. (Am. J. Hum. Genet. 2002)
    86. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    87. Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PubMed id 10514485)1, 2 Barton R.M. and Worman H.J. (J. Biol. Chem. 1999)
    88. In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease. (PubMed id 9030603)1, 2 Kilic F....Sinensky M. (J. Biol. Chem. 1997)
    89. An alternative splicing product of the lamin A/C gene lacks exon 10. (PubMed id 8621584)1, 2 Machiels B.M.... Broers J.L. (J. Biol. Chem. 1996)
    90. Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. (PubMed id 8838815)1, 3 Wydner K.L....Lawrence J.B. (Genomics 1996)
    91. Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. (PubMed id 8511676)1, 3 Kamat A.K....Miller O.J. (Somat. Cell Mol. Genet. 1993)
    92. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. (PubMed id 3453101)1, 2 McKeon F.D.... Caput D. (Nature 1986)
    93. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. (PubMed id 3462705)1, 2 Fisher D.Z.... Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    94. Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma. (PubMed id 19144202)1, 9 Wu Z....Zhao F. (amp 2009)
    95. Identification of mutational hot spots in LMNA encoding lamin A/C in patients with familial dilated cardiomyopathy. (PubMed id 18795223)1, 9 Perrot A....Ozcelik C. (Basic Res. Cardiol. 2009)
    96. Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis. (PubMed id 18767923)1, 9 Rauner M....Hofbauer L.C. (J. Bone Miner. Res. 2009)
    97. High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinics. (PubMed id 18035086)1, 9 van Tintelen J.P....van den Berg M.P. (Am. Heart J. 2007)
    98. Lack of mutations in LMNA, its promoter region, and the cellular retinoic acid binding protein II (CRABP II) in HIV associated lipodystrophy. (PubMed id 12844477)1, 9 Behrens G.M....Schmidt H.H. (Eur. J. Med. Res. 2003)
    99. Lamin A/C deficiency as a cause of familial dilated cardiomyopathy. (PubMed id 19384091)1, 9 Malhotra R. and Mason P.K. (Curr. Opin. Cardiol. 2009)
    100. A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. (PubMed id 16278265)2, 9 Van Esch H.... Garg A. (J. Clin. Endocrinol. Metab. 2006)
    101. Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. (PubMed id 12524233)1, 9 Hegele R.A....Cao H. (Arterioscler. Thromb. Vasc. Biol. 2003)
    102. Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. (PubMed id 19638735)1, 9 Saga A....Shimokawa H. (Tohoku J. Exp. Med. 2009)
    103. R25G mutation in exon 1 of LMNA gene is associated with dilated cardiomyopathy and limb-girdle muscular dystrophy 1B. (PubMed id 20092787)1, 9 Yuan W.L....Huang W.J. (Chin. Med. J. 2009)
    104. Clinical and molecular genetic spectrum of autosomal dominant Emery- Dreifuss muscular dystrophy due to mutations of the lamin A/C gene. (PubMed id 10939567)2, 9 Bonne G.... Muntoni F. (Ann. Neurol. 2000)
    105. Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption. (PubMed id 20127487)1, 9 Gupta P....Tesson F. (Basic Res. Cardiol. 2010)
    106. Atypical progeroid syndrome due to heterozygous missense LMNA mutations. (PubMed id 19875478)1, 9 Garg A....Crow Y. (J. Clin. Endocrinol. Metab. 2009)
    107. LMNA messenger RNA expression in highly active antiretroviral therapy-treated HIV-positive patients. (PubMed id 18077842)1, 9 Miranda M....Vendrell J. (J. Acquir. Immune Defic. Syndr. 2007)
    108. Multitissular involvement in a family with LMNA and EMD mutations: Role of digenic mechanism? (PubMed id 17536044)1, 9 Ben Yaou R....Bonne G. (Neurology 2007)
    109. Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition. (PubMed id 16697197)1, 9 Holt I....Morris G.E. (Neuromuscul. Disord. 2006)
    110. Lamin A/C and polymeric actin in genome organization. (PubMed id 18612243)1, 9 Ondrej V....Kozubek S. (Mol. Cells 2008)
    111. Association of homozygous LMNA mutation R471C with new phenotype: mandibuloacral dysplasia, progeria, and rigid spine muscular dystrophy. (PubMed id 18348272)1, 9 Zirn B....Hahn A. (Am. J. Med. Genet. A 2008)
    112. Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy. (PubMed id 18364375)1, 9 Vantyghem M.C....Wemeau J.L. (J. Clin. Endocrinol. Metab. 2008)
    113. A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy. (PubMed id 18031308)1, 9 AraA_jo-Vilar D....Costa-Freitas A.T. (Clin. Endocrinol. (Oxf) 2008)
    114. Lamin A/C mutations associated with familial and sporadic cases of dilated cardiomyopathy in Koreans. (PubMed id 17334235)1, 9 Song K....Kim J.J. (amp 2007)
    115. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. (PubMed id 17612587)1, 9 Caron M....Vigouroux C. (Cell Death Differ. 2007)
    116. Dilated cardiomyopathy caused by LMNA mutations. Clinical and morphological studies. (PubMed id 16981056)1, 9 BiliA8ska Z.T....RuzyA8A8o W. (Kardiol Pol 2006)
    117. [Clinical, genealogical and molecular genetic study of Emery-Dreifuss muscular dystrophy]. (PubMed id 17117676)1, 9 Rudenskaia G.E....Poliakov A.V. (Zh Nevrol Psikhiatr Im S S Korsakova 2006)
    118. [A novel LMNA gene mutation E82K associated with familial dilated cardiomyopathy]. (PubMed id 16266469)1, 9 Wang H....Hui R.T. (Zhonghua Xin Xue Guan Bing Za Zhi 2005)
    119. Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. (PubMed id 19172989)1, 9 Rodriguez S....Eriksson M. (Eur. J. Hum. Genet. 2009)
    120. Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. (PubMed id 17870066)1, 9 Huang S....Oshima J. (Exp. Cell Res. 2008)
    121. Lamin A/C is a risk biomarker in colorectal cancer. (PubMed id 18714339)1, 9 Willis N.D....Hutchison C.J. (PLoS ONE 2008)
    122. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. (PubMed id 17701980)1, 9 Maioli M.A....Marrosu M.G. (amp 2007)
    123. Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. (PubMed id 17469202)1, 9 Moulson C.L....Miner J.H. (Hum. Mutat. 2007)
    124. Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. (PubMed id 16239243)1, 9 Arocena D.G....Hagerman P.J. (Hum. Mol. Genet. 2005)
    125. Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy. (PubMed id 12788894)1, 9 Simha V....Garg A. (J. Clin. Endocrinol. Metab. 2003)
    126. Dyslipemia in familial partial lipodystrophy caused by an R482W mutation in the LMNA gene. (PubMed id 11344241)1, 9 Schmidt H.H....Brabant G. (J. Clin. Endocrinol. Metab. 2001)
    127. LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration. (PubMed id 10999791)1, 9 Hegele R.A....Anderson C.M. (J. Clin. Endocrinol. Metab. 2000)
    128. Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins. (PubMed id 10984438)1, 9 Dechat T....Foisner R. (J. Cell Sci. 2000)
    129. Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype. (PubMed id 20155465)1, 9 Wu X....Yang J. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2010)
    130. LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance. (PubMed id 20130076)1, 9 Boschmann M....Jordan J. (J. Clin. Endocrinol. Metab. 2010)
    131. LMNA, ZMPSTE24, and LBR are not mutated in scleroderma. (PubMed id 19645629)1, 9 Gaudy-Marqueste C....De Sandre-Giovannoli A. (Genet Test Mol Biomarkers 2009)
    132. Germinal mosaicism for LMNA mimics autosomal recessive congenital muscular dystrophy. (PubMed id 19084400)1, 9 Makri S....Guicheney P. (Neuromuscul. Disord. 2009)
    133. Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of beta-catenin. (PubMed id 19126678)1, 9 Tilgner K....Markiewicz E. (J. Cell. Sci. 2009)
    134. The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation. (PubMed id 19201734)1, 9 Wojtanik K.M....Londos C. (J. Lipid Res. 2009)
    135. LMNA mRNA expression is altered in human obesity and type 2 diabetes. (PubMed id 18497734)1, 9 Miranda M....Vendrell J. (Obesity (Silver Spring) 2008)
    136. Emerinopathy and laminopathy clinical, pathological and molecular features of muscular dystrophy with nuclear envelopathy in Japan. (PubMed id 18646565)1, 9 Astejada M.N....Hayashi Y.K. (Acta Myol 2007)
    137. Malignant mutation in the lamin A/C gene causing progressive conduction system disease and early sudden death in a family with mild form of limb-girdle muscular dystrophy. (PubMed id 17605093)1, 9 Antoniades L....Katritsis D.G. (J Interv Card Electrophysiol 2007)
    138. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. (PubMed id 16481476)1, 9 Frock R.L....Kennedy B.K. (amp 2006)
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    140. Emerin interacts in vitro with the splicing-associated factor, YT521- B. (PubMed id 12755701)1, 9 Wilkinson F.L.... Morris G.E. (Eur. J. Biochem. 2003)
    141. Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene. (PubMed id 14510863)4, 9 Owen K.R....Hattersley A.T. (Diabet. Med. 2003)
    142. A novel lamin A/C mutation in a family with dilated cardiomyopathy, prominent conduction system disease, and need for permanent pacemaker implantation. (PubMed id 12486434)2, 9 Hershberger R.E.... Litt M. (Am. Heart J. 2002)
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    144. Mouse and human hemopoietic cell lines of erythroid lineage express lamins A,B and C. (PubMed id 1599464)1, 9 Martelli A.M....Cocco L. (Biochem. Biophys. Res. Commun. 1992)
    145. Connexin 43 remodeling induced by LMNA gene mutation Glu82Lys in familial dilated cardiomyopathy with atrial ventricular block. (PubMed id 20497714)1, 9 Sun L.P....Pu J.L. (Chin. Med. J. 2010)
    146. Muscle imaging analogies in a cohort of patients with different clinical phenotypes caused by LMNA gene mutations. (PubMed id 19882644)1, 9 Carboni N....Marrosu M.G. (amp 2010)
    147. Expanding the phenotype of sudden cardiac death-An unusual presentation of a family with a Lamin A/C mutation. (PubMed id 18691775)1, 9 De Backer J....Duytschaever M. (Int. J. Cardiol. 2010)
    148. A novel LMNA mutation (R189W) in familial dilated cardiomyopathy: evidence for a 'hot spot' region at exon 3: a case report. (PubMed id 20307303)1, 9 Botto N....Andreassi M.G. (Cardiovasc Ultrasound 2010)
    149. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. (PubMed id 19328042)1, 9 Pan H....Garg V. (Heart Rhythm 2009)
    150. Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. (PubMed id 18805829)1, 9 AraA_jo-Vilar D....Lado-Abeal J. (J. Med. Genet. 2009)
    151. Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS. (PubMed id 19727227)1, 9 Ju W.N....Zhong N. (Beijing Da Xue Xue Bao 2009)
    152. Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. (PubMed id 19124654)1, 9 MAcjat A....Misteli T. (J. Cell Biol. 2009)
    153. Heart transplantation in 7 patients from a single family with limb-girdle muscular dystrophy caused by lamin A/C mutation. (PubMed id 19446900)1, 9 Ambrosi P....Habib G. (Int. J. Cardiol. 2009)
    154. Novel LMNA gene mutation in a patient with Atypical Werner's Syndrome. (PubMed id 19270485)1, 9 Doh Y.J....Lee I.K. (Korean J. Intern. Med. 2009)
    155. Emery-Dreifuss dystrophy: a 4-year follow-up on a laminopathy of special interest. (PubMed id 20054742)1, 9 Hausmanowa-Petrusewicz I....Opolski G. (Neurol. Neurochir. Pol. 2009)
    156. Absence of Lamin A/C gene mutations in four Wiedemann-Rautenstrauch syndrome patients. (PubMed id 19938095)1, 9 Morales L.C....Arboleda H. (Am. J. Med. Genet. A 2009)
    157. Obliteration of cardiomyocyte nuclear architecture in a patient with LMNA gene mutation. (PubMed id 18502446)1, 9 FidziaA8ska A....Hausmanowa-Petrusewicz I. (J. Neurol. Sci. 2008)
    158. Muscle MRI findings in patients with an apparently exclusive cardiac phenotype due to a novel LMNA gene mutation. (PubMed id 18337098)1, 9 Carboni N....Marrosu M.G. (Neuromuscul. Disord. 2008)
    159. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (PubMed id 17987279)1, 9 Geiger S.K....Weichenhan D. (J. Mol. Med. 2008)
    160. Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation. (PubMed id 18339564)1, 9 Madej-Pilarczyk A....Hausmanowa-Petrusewicz I. (Eur. J. Paediatr. Neurol. 2008)
    161. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. (PubMed id 18442998)1, 9 Wang Y....Worman H.J. (Hum. Mol. Genet. 2008)
    162. A novel LMNA gene mutation Leu162Pro and the associated clinical characteristics in a family with autosomal-dominant emery-dreifuss muscular dystrophy. (PubMed id 18816602)1, 9 Kim H.Y....Sung I.H. (amp 2008)
    163. A novel mutation in a large French-Canadian family with LGMD1B. (PubMed id 18714801)1, 9 Chrestian N....DuprAc N. (Can J Neurol Sci 2008)
    164. Long-term outcome and risk stratification in dilated cardiolaminopathies. (PubMed id 18926329)1, 9 Pasotti M....Arbustini E. (J. Am. Coll. Cardiol. 2008)
    165. Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C. (PubMed id 18478590)1, 9 Rankin J....Ellard S. (Am. J. Med. Genet. A 2008)
    166. Expression of the myodystrophic R453W mutation of lamin A in C2C12 myoblasts causes promoter-specific and global epigenetic defects. (PubMed id 18396274)1, 9 HAYkelien A.M....Collas P. (Exp. Cell Res. 2008)
    167. Founder effect and estimation of the age of the c.892C&gt;T (p.Arg298Cys) mutation in LMNA associated to Charcot-Marie-Tooth subtype CMT2B1 in families from North Western Africa. (PubMed id 18549403)1, 9 Hamadouche T....Delague V. (Ann. Hum. Genet. 2008)
    168. The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation. (PubMed id 18604166)1, 9 di Masi A....Novelli G. (Cell Cycle 2008)
    169. Mandibuloacral dysplasia and a novel LMNA mutation in a woman with severe progressive skeletal changes. (PubMed id 17935239)1, 9 Kosho T....Fukushima Y. (Am. J. Med. Genet. A 2007)
    170. [The role of lamins and mutations of LMNA gene in physiological and premature aging]. (PubMed id 17718387)1, 9 SliwiA8ska M.A. (Postepy Biochem. 2007)
    171. New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome. (PubMed id 17711925)1, 9 Decaudain A....Vigouroux C. (J. Clin. Endocrinol. Metab. 2007)
    172. The heterozygous LMNA mutation p.R471G causes a variable phenotype with features of two types of familial partial lipodystrophy. (PubMed id 18041775)1, 9 Muschke P....Wieacker P. (Am. J. Med. Genet. A 2007)
    173. Hutchinson-Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature. (PubMed id 17459035)1, 9 Mazereeuw-Hautier J....Harper J.I. (Br. J. Dermatol. 2007)
    174. Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. (PubMed id 17550303)1, 9 Lee T.H....Avraham S. (PLoS Med. 2007)
    175. Novel LMNA mutations seen in patients with familial partial lipodystrophy subtype 2 (FPLD2; MIM 151660). (PubMed id 17250669)2, 9 Lanktree M.... Hegele R.A. (Clin. Genet. 2007)
    176. Prelamin A farnesylation and progeroid syndromes. (PubMed id 17090536)1, 9 Young S.G....Fong L.G. (J. Biol. Chem. 2006)
    177. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. (PubMed id 17097067)1, 9 Muchir A....Worman H.J. (Biochem. Biophys. Res. Commun. 2006)
    178. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. (PubMed id 16461887)1, 9 McClintock D....Djabali K. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    179. Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy. (PubMed id 16825283)1, 9 Wang Y....Worman H.J. (Hum. Mol. Genet. 2006)
    180. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. (PubMed id 16179429)1, 9 Constantinescu D....Csoka A.B. (Stem Cells 2006)
    181. Deletion of the LMNA initiator codon leading to a neurogenic variant of autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 15639119)1, 9 Walter M.C....LochmA1ller H. (Neuromuscul. Disord. 2005)
    182. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. (PubMed id 15671068)1, 9 Zhang Q.... Shanahan C.M. (J. Cell Sci. 2005)
    183. The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene. (PubMed id 15668447)1, 9 van Engelen B.G....Lammens M. (Neurology 2005)
    184. Major myofibrillar changes in early onset myopathy due to de novo heterozygous missense mutation in lamin A/C gene. (PubMed id 16288872)1, 9 D'Amico A....Bertini E. (Neuromuscul. Disord. 2005)
    185. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. (PubMed id 15982412)1, 9 Paradisi M....Djabali K. (BMC Cell Biol. 2005)
    186. Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. (PubMed id 16126733)1, 9 Glynn M.W. and Glover T.W. (Hum. Mol. Genet. 2005)
    187. Lamins A and C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 16218190)1, 9 Motsch I....Ellis J.A. (Eur. J. Cell Biol. 2005)
    188. Type A insulin resistance syndrome revealing a novel lamin A mutation. (PubMed id 15919811)1, 9 Young J....Vigouroux C. (Diabetes 2005)
    189. Laminopathies and atherosclerosis. (PubMed id 15205220)1, 9 Al-Shali K.Z. and Hegele R.A. (Arterioscler. Thromb. Vasc. Biol. 2004)
    190. Paternal origin of LMNA mutations in Hutchinson-Gilford progeria. (PubMed id 15032975)1, 9 D'Apice M.R....Novelli G. (Clin. Genet. 2004)
    191. Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene. (PubMed id 15298354)1, 9 Savage D.B....Schafer A.J. (Diabetologia 2004)
    192. Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A/C. (PubMed id 14607793)4, 9 Tazir M....Grid D. (Brain 2004)
    193. A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies. (PubMed id 15026149)1, 9 Manilal S....Morris G.E. (Biochim. Biophys. Acta 2004)
    194. The phenotypic manifestations of autosomal recessive axonal Charcot-Marie-Tooth due to a mutation in Lamin A/C gene. (PubMed id 12467734)1, 9 Chaouch M....Grid D. (Neuromuscul. Disord. 2003)
    195. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. (PubMed id 12783988)1, 9 Holt I....Morris G.E. (J. Cell. Sci. 2003)
    196. Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription. (PubMed id 14597414)1, 9 Capanni C....Lattanzi G. (Exp. Cell Res. 2003)
    197. Mandibuloacral dysplasia caused by homozygosity for the R527H mutation in lamin A/C. (PubMed id 14627682)1, 9 Shen J.J....Potocki L. (J. Med. Genet. 2003)
    198. The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. (PubMed id 11709282)1, 9 Mounkes L.C....Stewart C.L. (Trends Cardiovasc. Med. 2001)
    199. Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. (PubMed id 11792810)1, 9 Raharjo W.H....Burke B. (J. Cell. Sci. 2001)
    200. Skeletal muscle pathology in autosomal dominant Emery-Dreifuss muscular dystrophy with lamin A/C mutations. (PubMed id 11532159)1, 9 Sewry C.A....Muntoni F. (Neuropathol. Appl. Neurobiol. 2001)
    201. Novel lamin A/C mutations in two families with dilated cardiomyopathy and conduction system disease. (PubMed id 11561226)2, 9 Jakobs P.M.... Hershberger R.E. (J. Card. Fail. 2001)
    202. A missense mutation in the exon 8 of lamin A/C gene in a Japanese case of autosomal dominant limb-girdle muscular dystrophy and cardiac conduction block. (PubMed id 11525883)2, 9 Kitaguchi T.... Bonne G. (Neuromuscul. Disord. 2001)
    203. [Major insulin resistance syndromes: clinical and physiopathological aspects]. (PubMed id 11833462)1, 9 Vigouroux C....Capeau J. (J. Soc. Biol. 2001)
    204. Phenotypic heterogeneity in patients with familial partial lipodystrophy (dunnigan variety) related to the site of missense mutations in lamin a/c gene. (PubMed id 11231979)1, 9 Garg A....Bowcock A.M. (J. Clin. Endocrinol. Metab. 2001)
    205. Structural alterations of Lamin A protein in dilated cardiomyopathy. (PubMed id 23701190)1 Bhattacharjee P....Sengupta K. (Biochemistry 2013)
    206. Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling. (PubMed id 23427149)1 Zwerger M....Lammerding J. (Hum. Mol. Genet. 2013)
    207. Hutchinson-Gilford progeria syndrome: report of 2 cases and a novel LMNA mutation of HGPS in China. (PubMed id 24034385)1 Zhang H....Yao Z. (J. Am. Acad. Dermatol. 2013)
    208. LMNA mutations in Polish patients with dilated cardiomyopathy: prevalence, clinical characteristics, and in vitro studies. (PubMed id 23702046)1 Saj M....Ploski R. (BMC Med. Genet. 2013)
    209. The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression. (PubMed id 23430973)1 Bertacchini J....Marmiroli S. (FASEB J. 2013)
    210. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    211. Genetic analysis in 418 index patients with idiopathic dilated cardiomyopathy: overview of 10 years' experience. (PubMed id 23349452)1 van Spaendonck-Zwarts K.Y....van Tintelen J.P. (Eur. J. Heart Fail. 2013)
    212. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. (PubMed id 23631840)1 Arimura T....Kimura A. (Cardiovasc. Res. 2013)
    213. [Lamin A/C mutations change differentiation potential of mesenchymal stem cells]. (PubMed id 24592738)1 Malashicheva A.B....Kostareva A.A. (Tsitologiia 2013)
    214. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. (PubMed id 23788249)1 Green R.C....Biesecker L.G. (Genet. Med. 2013)
    215. Dilated cardiomyopathy and skeletal myopathy: presenting features of a laminopathy. (PubMed id 23329710)1 Sims-Williams H.P....Walker P.R. (BMJ Case Rep 2013)
    216. Changes in vimentin, lamin A/C and mitofilin induceA aberrant cell organization in fibroblasts from Fanconi anemia complementation group A (FA-A) patients. (PubMed id 23831462)1 Capanni C....Cappelli E. (Biochimie 2013)
    217. Identification of FAM96B as a novel prelamin A binding partner. (PubMed id 24041693)1 Xiong X.D....Liu X. (Biochem. Biophys. Res. Commun. 2013)
    218. The LMNA mutation p.Arg321Ter associated with dilated cardiomyopathy leads to reduced expression and a skewed ratio of lamin A and lamin C proteins. (PubMed id 24001739)1 Al-Saaidi R....Bross P. (Exp. Cell Res. 2013)
    219. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. (PubMed id 23319047)1 Singh M....Pandita T.K. (Mol. Cell. Biol. 2013)
    220. Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations. (PubMed id 23324461)1 Tamiello C....Bouten C.C. (Nucleus 2013)
    221. Gender-specific differences in major cardiac events and mortality in lamin A/C mutation carriers. (PubMed id 23183350)1 van Rijsingen I.A....Pinto Y.M. (Eur. J. Heart Fail. 2013)
    222. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. (PubMed id 23990565)1 Swift J....Discher D.E. (Science 2013)
    223. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    224. A novel lamin A/C mutation in a Dutch family with premature atherosclerosis. (PubMed id 23659872)1 Weterings A.A....Pinto-Sietsma S.J. (Atherosclerosis 2013)
    225. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. (PubMed id 23695662)2 Liu B....Zhou Z. (Nat Commun 2013)
    226. Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations. (PubMed id 23243001)1 Simon D.N....Wilson K.L. (Mol. Biol. Cell 2013)
    227. Genetic and clinical characteristics of skeletal and cardiac muscle in patients with lamin A/C gene mutations. (PubMed id 23450819)1 Carboni N....Marrosu M.G. (amp 2013)
    228. Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells. (PubMed id 23564641)1 Liu Y....Shanahan C.M. (Circ. Res. 2013)
    229. CMR-verified interstitial myocardial fibrosis as a marker of subclinical cardiac involvement in LMNA mutation carriers. (PubMed id 23328570)1 Fontana M....Masci P.G. (JACC Cardiovasc Imaging 2013)
    230. Elevated MTORC1 signaling and impaired autophagy. (PubMed id 23064282)1 Ramos F.J....Kennedy B.K. (Autophagy 2013)
    231. Homozygous lamin A/C familial lipodystrophy R482Q mutation in autosomal recessive Emery Dreifuss muscular dystrophy. (PubMed id 23313286)1 Wiltshire K.M....Brownell A.K. (Neuromuscul. Disord. 2013)
    232. Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity. (PubMed id 24067370)1 Jung Y.S....Park B.J. (Cell Cycle 2013)
    233. Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction. (PubMed id 23846499)1 Bidault G....BAcrAcziat V. (Arterioscler. Thromb. Vasc. Biol. 2013)
    234. Temporal relationship of conduction system disease and ventricular dysfunction in LMNA cardiomyopathy. (PubMed id 23582089)1 Brodt C....Hershberger R.E. (J. Card. Fail. 2013)
    235. Multisystem disorder and limb girdle muscular dystrophy caused by LMNA p.R28W mutation. (PubMed id 23746545)1 TA1rk M....Chevessier F. (Neuromuscul. Disord. 2013)
    236. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    237. Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy. (PubMed id 22199124)1 Quarta G....Elliott P.M. (Eur. Heart J. 2012)
    238. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    239. Variants of the lamin A/C (LMNA) gene in non-valvular atrial fibrillation patients: a possible pathogenic role of the Thr528Met mutation. (PubMed id 22413764)1 Saj M....Ploski R. (amp 2012)
    240. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. (PubMed id 22301279)1 Kong L....Klocker H. (Carcinogenesis 2012)
    241. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    242. A bioinformatics analysis of Lamin-A regulatory network: a perspective on epigenetic involvement in Hutchinson-Gilford progeria syndrome. (PubMed id 22533413)1 Arancio W. (Rejuvenation Res 2012)
    243. Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cells: essential role of sp1 in the integrity of lipid vesicles. (PubMed id 23197810)1 Ruiz de Eguino G....RodrA-guez C.I. (Stem Cells Transl Med 2012)
    244. Human longevity and common variations in the LMNA gene: a meta-analysis. (PubMed id 22340368)1 Conneely K.N....Collins F.S. (Aging Cell 2012)
    245. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. (PubMed id 22555846)1 Muteliefu G....Niwa T. (Am. J. Physiol., Cell Physiol. 2012)
    246. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    247. Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA. (PubMed id 22840390)1 Nissan X....Peschanski M. (Cell Rep 2012)
    248. Blood glutathione decrease in subjects carrying lamin A/C gene mutations is an early marker of cardiac involvement. (PubMed id 22071332)1 Meune C....Pecker F. (Neuromuscul. Disord. 2012)
    249. S100A6 is transcriptionally regulated by I^-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells. (PubMed id 22560296)1 KilaA8czyk E....Filipek A. (Cell Calcium 2012)
    250. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    251. Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24. (PubMed id 22355414)2 Barrowman J.... Michaelis S. (PLoS ONE 2012)
    252. Protein profiling reveals energy metabolism and cytoskeletal protein alterations in LMNA mutation carriers. (PubMed id 22326558)1 Magagnotti C....Benedetti S. (Biochim. Biophys. Acta 2012)
    253. LMNA knock-down affects differentiation and progression of human neuroblastoma cells. (PubMed id 23049808)1 Maresca G....D'Agnano I. (PLoS ONE 2012)
    254. Structures of the lamin A/C R335W and E347K mutants: implications for dilated cardiolaminopathies. (PubMed id 22266370)1 Bollati M....Bolognesi M. (Biochem. Biophys. Res. Commun. 2012)
    255. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. (PubMed id 23048029)1 Choi J.C....Worman H.J. (J. Biol. Chem. 2012)
    256. Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties. (PubMed id 22893709)1 Schmidt E....Eriksson M. (J. Biol. Chem. 2012)
    257. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    258. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    259. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    260. Abnormal p38I+ mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. (PubMed id 22773734)1 Muchir A....Worman H.J. (Hum. Mol. Genet. 2012)
    261. Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (Mol. Cell. Biochem. 2012)
    262. Methylation status of lamin A/C in gastric cancer cell lines. (PubMed id 22057372)1 Lee W.S....Rha S.Y. (Hepatogastroenterology 2012)
    263. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    264. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    265. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (Mol. Cell. Biochem. 2012)
    266. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    267. Phenotypic diversity in patients with lipodystrophy associated with LMNA mutations. (PubMed id 22700598)1 Mory P.B....MoisAcs R.S. (Eur. J. Endocrinol. 2012)
    268. A novel homozygous p.Arg527Leu LMNA mutation in two unrelated Egyptian families causes overlapping mandibuloacral dysplasia and progeria syndrome. (PubMed id 22549407)1 Al-Haggar M....Puzianowska-Kuznicka M. (Eur. J. Hum. Genet. 2012)
    269. LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle. (PubMed id 22186027)1 Dialynas G....Wallrath L.L. (Hum. Mol. Genet. 2012)
    270. Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study. (PubMed id 22281253)1 van Rijsingen I.A....Pinto Y.M. (J. Am. Coll. Cardiol. 2012)
    271. Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy. (PubMed id 22224630)1 Stallmeyer B....Schulze-Bahr E. (Genet Test Mol Biomarkers 2012)
    272. Cardiac involvement in patients with lamin A/C gene mutations: a cohort observation. (PubMed id 22806367)1 Carboni N....Marrosu M.G. (amp 2012)
    273. Perturbation of nuclear lamin A causes cell death in chondrocytes. (PubMed id 22231515)1 Attur M....Abramson S.B. (Arthritis Rheum. 2012)
    274. Quantitative expression of the mutated lamin A/C gene in patients with cardiolaminopathy. (PubMed id 23062543)1 Narula N....Arbustini E. (J. Am. Coll. Cardiol. 2012)
    275. C1824T mutation in the LMNA gene has no association with senile cataract. (PubMed id 22079058)1 Sadikov T....Goldenberg-Cohen N. (Neurobiol. Aging 2012)
    276. Inflammatory changes in infantile-onset LMNA-associated myopathy. (PubMed id 21632249)1 Komaki H....Nishino I. (Neuromuscul. Disord. 2011)
    277. Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling. (PubMed id 21486941)1 Meyer A.J....Krauss S.W. (J. Cell. Sci. 2011)
    278. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. (PubMed id 21346760)1 Liu G.H....Izpisua Belmonte J.C. (Nature 2011)
    279. Sudden cardiac death in a patient with lamin A/C mutation in the absence of dilated cardiomyopathy or conduction disease. (PubMed id 21327842)1 Ehlermann P....Schimpf R. (Clin Res Cardiol 2011)
    280. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. (PubMed id 21596650)1 Liu G.H....Izpisua Belmonte J.C. (Cell Stem Cell 2011)
    281. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    282. Assessment of LMNA copy number variation in 58 probands with dilated cardiomyopathy. (PubMed id 22029807)1 Norton N....Hershberger R.E. (Clin Transl Sci 2011)
    283. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    284. Gene expression, chromosome position and lamin A/C mutations. (PubMed id 21818408)1 Puckelwartz M.J....McNally E.M. (Nucleus 2011)
    285. Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins. (PubMed id 21993218)1 Duband-Goulet I....Buendia B. (Exp. Cell Res. 2011)
    286. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    287. Polymorphisms in LMNA and near a SERPINA13 gene are not associated with cognitive performance in Chinese elderly males without dementia. (PubMed id 21903150)1 Yeh H.L....Tsai S.J. (Neurosci. Lett. 2011)
    288. Aberrant splicing in the LMNA gene caused by a novel mutation on the polypyrimidine tract of intron 5. (PubMed id 21462202)1 Carboni N....Marrosu M.G. (amp 2011)
    289. LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue. (PubMed id 21945321)1 BAcrAcziat V....Vigouroux C. (Am. J. Pathol. 2011)
    290. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    291. Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy. (PubMed id 21689390)1 HolmstrAPm M....Lauerma K. (J Cardiovasc Magn Reson 2011)
    292. A complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death. (PubMed id 21406687)1 Marsman R.F....Bezzina C.R. (Circ Cardiovasc Genet 2011)
    293. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    294. Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin Aa88/C-depleted cells. (PubMed id 21535365)1 Moiseeva O....Ferbeyre G. (Aging Cell 2011)
    295. Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. (PubMed id 21350821)1 Verstraeten V.L....Broers J.L. (Histochem. Cell Biol. 2011)
    296. Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates. (PubMed id 21915271)1 BAPkenkamp R....Gittenberger-de Groot A.C. (PLoS ONE 2011)
    297. A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. (PubMed id 21098080)1 Galisson F....Thibault P. (amp 2011)
    298. Amphibian oocyte nuclei expressing lamin A with the progeria mutation E145K exhibit an increased elastic modulus. (PubMed id 21941106)1 Kaufmann A....Stick R. (Nucleus 2011)
    299. Laminopathies and lamin-associated signaling pathways. (PubMed id 21400569)1 Maraldi N.M....Lattanzi G. (J. Cell. Biochem. 2011)
    300. Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer. (PubMed id 21627864)1 Capo-chichi C.D....Xu X.X. (Chin J Cancer 2011)
    301. Genotype of the LMNA 1908C&gt;T variant is associated with generalized obesity in Asian Indians in North India. (PubMed id 21599722)1 Sharma M....Luthra K. (Clin. Endocrinol. (Oxf) 2011)
    302. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    303. [Laminopathies: one gene, several diseases]. (PubMed id 21982404)1 Bertrand A.T....Bonne G. (Biol Aujourdhui 2011)
    304. LMNA mutation in progeroid syndrome in association with strokes. (PubMed id 21791255)2 Gonzalez-Quereda L.... Gallano P. (Eur. J. Med. Genet. 2011)
    305. N-terminal Pro brain natriuretic peptide is a reliable biomarker of reduced myocardial contractility in patients with lamin A/C gene mutations. (PubMed id 20627339)1 Meune C....Bonne G. (Int. J. Cardiol. 2011)
    306. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    307. Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. (PubMed id 21439080)1 Capo-chichi C.D....Xu X.X. (BMC Med 2011)
    308. Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development. (PubMed id 21980471)1 RodrA-guez S. and Eriksson M. (PLoS ONE 2011)
    309. Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence. (PubMed id 21621406)1 Belt E.J....Meijer G.A. (Eur. J. Cancer 2011)
    310. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. (PubMed id 21670498)1 Cao K....Collins F.S. (J. Clin. Invest. 2011)
    311. The nucleoporin Nup88 is interacting with nuclear lamin A. (PubMed id 21289091)1 Lussi Y.C....Fahrenkrog B. (Mol. Biol. Cell 2011)
    312. High prevalence of laminopathies among patients with metabolic syndrome. (PubMed id 21724554)1 Dutour A....Morange P.E. (Hum. Mol. Genet. 2011)
    313. A homozygous mutation of prelamin-A preventing its farnesylation and maturation leads to a severe lipodystrophic phenotype: new insights into the pathogenicity of nonfarnesylated prelamin-A. (PubMed id 21346069)1 Le Dour C....Vigouroux C. (J. Clin. Endocrinol. Metab. 2011)
    314. Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle. (PubMed id 21311568)1 Mattioli E....Lattanzi G. (Cell Death Differ. 2011)
    315. Myotonic dystrophy protein kinase is critical for nuclear envelope integrity. (PubMed id 21949239)2 Harmon E.B....Perryman M.B. (J. Biol. Chem. 2011)
    316. The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. (PubMed id 21670151)1 Kelley J.B....Paschal B.M. (Mol. Cell. Biol. 2011)
    317. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    318. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. (PubMed id 20974128)1 Candelario J....Comai L. (Exp. Cell Res. 2011)
    319. A new c.1621 C &gt; G, p.R541G lamin A/C mutation in a family with DCM and regional wall motion abnormalities (akinesis/dyskinesis): genotype-phenotype correlation. (PubMed id 21085127)1 MaA8ek L.A....BiliA8ska Z.T. (J. Hum. Genet. 2011)
    320. Subcellular localization of SUN2 is regulated by lamin A and Rab5. (PubMed id 21655223)1 Liang Y....Chan S.Y. (PLoS ONE 2011)
    321. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    322. A conserved splicing mechanism of the LMNA gene controls premature aging. (PubMed id 21875900)1 Lopez-Mejia I.C....Tazi J. (Hum. Mol. Genet. 2011)
    323. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    324. Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A. (PubMed id 22065502)1 Hisama F.M....Oshima J. (Am. J. Med. Genet. A 2011)
    325. Two children with &quot;dropped head&quot; syndrome due to lamin A/C mutations. (PubMed id 20886652)1 Chemla J.C....Smith E.C. (amp 2010)
    326. Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. (PubMed id 20819672)1 Cai M.Y....Weng J.P. (Chin. Med. J. 2010)
    327. Overlapping syndrome with familial partial lipodystrophy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous missense lamin A/C mutations. (PubMed id 20041886)1 Subramanyam L....Garg A. (Clin. Genet. 2010)
    328. Lamin A precursor induces barrier-to-autointegration factor nuclear localization. (PubMed id 20581439)1 Capanni C....Lattanzi G. (Cell Cycle 2010)
    329. Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. (PubMed id 20605919)1 Benson E.K....Aaronson S.A. (J. Cell. Sci. 2010)
    330. Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant. (PubMed id 20147387)1 Meng Q....Kenney S.C. (J. Virol. 2010)
    331. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (J. Proteome Res. 2010)
    332. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    333. Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients. (PubMed id 19958786)1 Viteri G....Stadtman E.R. (Mech. Ageing Dev. 2010)
    334. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (Cell Cycle 2010)
    335. Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 &quot;half-minilamin&quot; dimers. (PubMed id 20004208)1 Kapinos L.E....Herrmann H. (J. Mol. Biol. 2010)
    336. Evolution of the phenotype in a family with an LMNA gene mutation presenting with isolated cardiac involvement. (PubMed id 19768759)1 Carboni N....Marrosu M.G. (amp 2010)
    337. LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice. (PubMed id 21151901)1 Lu D....Zhang L. (PLoS ONE 2010)
    338. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (FEBS J. 2010)
    339. [Nucleopathies in children]. (PubMed id 21462476)1 Madej-Pilarczyk A. (Med Wieku Rozwoj 2010)
    340. Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin. (PubMed id 20884875)1 LefA"vre C....Caron-Debarle M. (Arterioscler. Thromb. Vasc. Biol. 2010)
    341. Adipose tissue lamin A/C messenger RNA expression in women. (PubMed id 20045150)1 Nadeau M....Tchernof A. (Metab. Clin. Exp. 2010)
    342. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1 Chaturvedi P. and Parnaik V.K. (PLoS ONE 2010)
    343. Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (Cytoskeleton (Hoboken) 2010)
    344. Identification of a lamin A/C gene mutation in a Taiwanese family with limb girdle muscular dystrophy and cardiomyopathy. (PubMed id 20615561)1 Chang S.H....Lei M.H. (Int. J. Cardiol. 2010)
    345. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    346. Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. (PubMed id 21179469)1 Mewborn S.K....McNally E. (PLoS ONE 2010)
    347. [Mutation analysis of LITAF, RAB7, LMNA and MTMR2 genes in Chinese Charcot-Marie-Tooth disease.]. (PubMed id 20709679)1 Zhang R.X....Tang B.S. (Yi Chuan 2010)
    348. Familial partial lipodystrophy associated with the heterozygous LMNA mutation 1445G&gt;A (Arg482Gln) in a Polish family. (PubMed id 20625965)1 Drac H....Hausmanowa-Petrusewicz I. (Neurol. Neurochir. Pol. 2010)
    349. Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling. (PubMed id 19725029)1 Zhu B....Kyprianou N. (Prostate 2010)
    350. Kinetic analysis of RNA interference for lamin A/C in HeLa cells. (PubMed id 20732854)1 You S.J....Lee J.S. (Acta Biochim. Biophys. Sin. (Shanghai) 2010)
    351. Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. (PubMed id 21327074)1 Simon D.N....Wilson K.L. (Nucleus 2010)
    352. Dynamics of lamin-A processing following precursor accumulation. (PubMed id 20526372)1 Liu Q....Roux K.J. (PLoS ONE 2010)
    353. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PubMed id 20574532)4 Shulman J.M....De Jager P.L. (PLoS ONE 2010)
    354. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    355. Comparison of phenotypes in male and female individuals of a new family with Dunnigan type of familial partial lipodystrophy due to a lamin A/C R482W mutation. (PubMed id 19204888)1 Laudes M....Krone W. (Horm. Metab. Res. 2009)
    356. The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. (PubMed id 19247430)1 Ottaviani A....Magdinier F. (PLoS Genet. 2009)
    357. Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF. (PubMed id 19644448)1 Ottaviani A....Magdinier F. (EMBO J. 2009)
    358. A comparative study of Drosophila and human A-type lamins. (PubMed id 19855837)1 Schulze S.R....Wallrath L.L. (PLoS ONE 2009)
    359. Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. (PubMed id 19759913)1 Montes de Oca R....Wilson K.L. (PLoS ONE 2009)
    360. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    361. A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. (PubMed id 19926845)1 Taimen P....Goldman R.D. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    362. Ageing-related chromatin defects through loss of the NURD complex. (PubMed id 19734887)1 Pegoraro G....Misteli T. (Nat. Cell Biol. 2009)
    363. Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle. (PubMed id 18643848)1 Yamamoto S....Hirai Y. (Exp. Dermatol. 2009)
    364. Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria. (PubMed id 19351612)1 Dominici S....Lattanzi G. (Eur J Histochem 2009)
    365. Association studies of 22 candidate SNPs with late-onset Alzheimer's disease. (PubMed id 18780302)4 Figgins J.A....Kamboh M.I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    366. Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD). (PubMed id 19574635)1 Magracheva E....Zdanov A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009)
    367. Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants. (PubMed id 19442658)1 Busch A....HA1bner S. (Exp. Cell Res. 2009)
    368. Impaired nuclear functions lead to increased senescence and inefficient differentiation in human myoblasts with a dominant p.R545C mutation in the LMNA gene. (PubMed id 19589617)1 Kandert S....Dabauvalle M.C. (Eur. J. Cell Biol. 2009)
    369. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
    370. Defects in cell spreading and ERK1/2 activation in fibroblasts with lamin A/C mutations. (PubMed id 19524666)1 Emerson L.J....Ellis J.A. (Biochim. Biophys. Acta 2009)
    371. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    372. Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells. (PubMed id 19022376)1 Muchir A....Worman H.J. (Biochim. Biophys. Acta 2009)
    373. Reduced expression of lamin A/C results in modified cell signaling and metabolism coupled with changes in expression of structural proteins. (PubMed id 19775189)1 Chen S....Jackson D.A. (J. Proteome Res. 2009)
    374. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (amp 2009)
    375. Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A/C. (PubMed id 19490114)1 Harper M....Ernoult-Lange M. (FEBS J. 2009)
    376. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    377. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    378. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PubMed id 17760566)1 Dreuillet C....Ernoult-Lange M. (Biol. Cell 2008)
    379. [The atypical of Werner syndrome: effect of laminopathy]. (PubMed id 18959190)1 Smirnova N.V....Mikhel'son V.M. (Tsitologiia 2008)
    380. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    381. Effects of prelamin A processing inhibitors on the differentiation and activity of human osteoclasts. (PubMed id 18442054)1 Zini N....Lattanzi G. (J. Cell. Biochem. 2008)
    382. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    383. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. (PubMed id 18843043)1 Kudlow B.A....Kennedy B.K. (Mol. Biol. Cell 2008)
    384. Drugs affecting prelamin A processing: effects on heterochromatin organization. (PubMed id 18093584)1 Mattioli E....Lattanzi G. (Exp. Cell Res. 2008)
    385. Tethering by lamin A stabilizes and targets the ING1 tumour suppressor. (PubMed id 18836436)1 Han X....Riabowol K. (Nat. Cell Biol. 2008)
    386. The binding of Tritrichomonas foetus to immobilized laminin-1 and its role in the cytotoxicity exerted by the parasite. (PubMed id 18667561)1 PetrA^polis D.B....Costa e Silva-Filho F. (Microbiology (Reading, Engl.) 2008)
    387. Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. (PubMed id 18946024)1 Isokane M....Higashiyama S. (J. Cell. Sci. 2008)
    388. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    389. Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. (PubMed id 18809582)1 Maggi L.B. Jr.... Weber J.D. (Mol. Cell. Biol. 2008)
    390. Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane. (PubMed id 18524819)1 Mou F....Baines J.D. (J. Virol. 2008)
    391. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (Proteomics 2008)
    392. Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. (PubMed id 18982914)1 Ding S.L. and Shen C.Y. (Clin Interv Aging 2008)
    393. [A-type lamins and progeroA^d syndromes : persistent farnesylation with dramatic effects]. (PubMed id 18950579)1 Navarro C.L....LAcvy N. (Med Sci (Paris) 2008)
    394. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    395. Laminopathies in Russian families. (PubMed id 18564364)1 Rudenskaya G.E....Ginter E.K. (Clin. Genet. 2008)
    396. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. (PubMed id 19015316)1 GonzA!lez J.M....AndrAcs V. (J. Cell Biol. 2008)
    397. Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. (PubMed id 18923140)1 Barrowman J....Michaelis S. (Mol. Biol. Cell 2008)
    398. Specific contribution of lamin A and lamin C in the development of laminopathies. (PubMed id 18538321)1 Sylvius N....Tesson F. (Exp. Cell Res. 2008)
    399. Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation. (PubMed id 18497856)1 Silva L....Knipe D.M. (PLoS Pathog. 2008)
    400. Muscle dystrophy single point mutation in the 2B segment of lamin A does not affect the mechanical properties at the dimer level. (PubMed id 18308323)1 Zhang H....Buehler M.J. (J Biomech 2008)
    401. Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. (PubMed id 17848622)1 Liu Y....Zou Y. (FASEB J. 2008)
    402. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. (PubMed id 19141474)1 Shimi T....Goldman R.D. (amp 2008)
    403. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. (PubMed id 18311132)1 Scaffidi P. and Misteli T. (Nat. Cell Biol. 2008)
    404. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. (PubMed id 17573780)1 Hayakawa T....Nakayama J. (amp 2007)
    405. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. (PubMed id 17683050)1 Cid C....Alcazar A. (Proteomics 2007)
    406. The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. (PubMed id 18060063)1 McClintock D....Djabali K. (PLoS ONE 2007)
    407. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. (PubMed id 17301031)1 Halaschek-Wiener J. and Brooks-Wilson A. (J. Gerontol. A Biol. Sci. Med. Sci. 2007)
    408. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. (PubMed id 17360355)1 Cao K....Collins F.S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    409. Obstructive sleep apnea in 2 women with familial partial lipodystrophy due to a heterozygous LMNA R482Q mutation. (PubMed id 17893350)1 Hegele R.A....Rutt B.K. (CMAJ 2007)
    410. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (Cell Cycle 2007)
    411. Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. (PubMed id 17227891)1 Pekovic V....Markiewicz E. (J. Cell Biol. 2007)
    412. Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells. (PubMed id 17291448)1 Pan Y....Agarwal A.K. (Biochem. Biophys. Res. Commun. 2007)
    413. Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. (PubMed id 17881656)1 Kandert S....Karakesisoglou I. (Hum. Mol. Genet. 2007)
    414. An emerin &quot;proteome&quot;: purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (Biochemistry 2007)
    415. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PubMed id 17342744)1 Dall'Era M.A....Liu A.Y. (Prostate 2007)
    416. Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55. (PubMed id 17306257)1 Le Bras S....Deckert M. (FEBS Lett. 2007)
    417. Oxidative stress implication in a new phenotype of amyotrophic quadricipital syndrome with cardiac involvement due to lamin A/C mutation. (PubMed id 17454124)1 Charniot J.C....Artigou J.Y. (Free Radic. Res. 2007)
    418. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)2 Yu L.R.... Veenstra T.D. (J. Proteome Res. 2007)
    419. US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cells. (PubMed id 17428859)1 Mou F....Baines J.D. (J. Virol. 2007)
    420. Accumulation of multiple forms of lamin A with down-regulation of FACE-1 suppresses growth in senescent human cells. (PubMed id 17352743)1 Ukekawa R....Ayusawa D. (amp 2007)
    421. Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. (PubMed id 17360326)1 Dechat T....Goldman R.D. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    422. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. (PubMed id 16738054)1 Shumaker D.K....Goldman R.D. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    423. Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo. (PubMed id 16371512)1 Bengtsson L. and Wilson K.L. (Mol. Biol. Cell 2006)
    424. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    425. Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. (PubMed id 16410549)1 Zastrow M.S.... Wilson K.L. (J. Cell Sci. 2006)
    426. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1 Kim S.C.... Zhao Y. (Mol. Cell 2006)
    427. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    428. Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by novel mutations of selenoprotein N gene. (PubMed id 16779558)1 Okamoto Y....Arimura K. (Neurogenetics 2006)
    429. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. (PubMed id 16452503)1 Ivorra C....AndrAcs V. (amp 2006)
    430. Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. (PubMed id 17069459)1 Radke J.R....White M.W. (PLoS Pathog. 2006)
    431. Dysfunction of lamin A triggers a DNA damage response and cellular senescence. (PubMed id 16344005)1 Lees-Miller S.P. (DNA Repair (Amst.) 2006)
    432. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. (PubMed id 16518869)1 Lee S.C....Pervaiz S. (Proteomics 2006)
    433. Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. (PubMed id 16772334)1 Manju K....Parnaik V.K. (J. Cell. Sci. 2006)
    434. Lamin A-dependent nuclear defects in human aging. (PubMed id 16645051)1 Scaffidi P. and Misteli T. (Science 2006)
    435. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1 Nousiainen M....KAPrner R. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    436. Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates. (PubMed id 16289535)1 HA1bner S....Jans D.A. (Exp. Cell Res. 2006)
    437. Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis. (PubMed id 16823856)1 Greenberg S.A....Amato A.A. (amp 2006)
    438. Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. (PubMed id 16212417)1 Catimel B....Nice E. (J. Proteome Res. 2005)
    439. Lamin A N-terminal phosphorylation is associated with myoblast activation: impairment in Emery-Dreifuss muscular dystrophy. (PubMed id 15744034)2 Cenni V.... Lattanzi G. (J. Med. Genet. 2005)
    440. Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations. (PubMed id 16246140)1 Meaburn K.J....Bridger J.M. (Biochem. Soc. Trans. 2005)
    441. Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)1 Kim J.E....White F.M. (J. Proteome Res. 2005)
    442. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PubMed id 16159877)1 McCracken S....Blencowe B.J. (J. Biol. Chem. 2005)
    443. Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. (PubMed id 16248985)1 Zhong N....Brown W.T. (Biochem. Biophys. Res. Commun. 2005)
    444. Somatic and gonadal mosaicism in Hutchinson-Gilford progeria. (PubMed id 15793835)1 Wuyts W....Storm K. (Am. J. Med. Genet. A 2005)
    445. Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization. (PubMed id 15748902)1 Broers J.L....Ramaekers F.C. (Exp. Cell Res. 2005)
    446. Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations? (PubMed id 16357800)1 Donadille B....Vigouroux C. (amp 2005)
    447. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    448. Gene symbol: LMNA. Disease: cardiomyopathy, dilated, with conduction defect 1. (PubMed id 16156025)2 Arbustini Eloisa A.E.... Tavazzi L. (Hum. Genet. 2005)
    449. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S.... Mann M. (Nature 2005)
    450. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. (PubMed id 16129833)1 Capell B.C....Collins F.S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    451. [Lamine gene mutations in dilated cardiomyopathy]. (PubMed id 15798706)1 Zakliaz'minskaia E.V....Poliakov A.V. (Kardiologiia 2005)
    452. Two patients with 'Dropped head syndrome' due to mutations in LMNA or SEPN1 genes. (PubMed id 15961312)1 D'Amico A....Topaloglu H. (Neuromuscul. Disord. 2005)
    453. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940)1 Zhao C.... Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    454. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)1 Guo D.... Wang C.-Y. (Biochem. Biophys. Res. Commun. 2005)
    455. Peripheral nerve lesions associated with a dominant missense mutation, E33D, of the lamin A/C gene. (PubMed id 16084085)1 Vital A....Vital C. (Neuromuscul. Disord. 2005)
    456. A novel mutation, Ser143Pro, in the lamin A/C gene is common in Finnish patients with familial dilated cardiomyopathy. (PubMed id 15140538)2 Kaerkkaeinen S.... Peuhkurinen K. (Eur. Heart J. 2004)
    457. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. (PubMed id 15184648)1 Goldman R.D....Collins F.S. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    458. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    459. The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. (PubMed id 15284226)1 Schirmer E.C. and Gerace L. (J. Biol. Chem. 2004)
    460. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. (PubMed id 15161933)1 Meek S.E....Piwnica-Worms H. (J. Biol. Chem. 2004)
    461. Adenomatous polyposis coli is down-regulated by the ubiquitin- proteasome pathway in a process facilitated by Axin. (PubMed id 15355978)1 Choi J.... Joo C.-K. (J. Biol. Chem. 2004)
    462. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (FEBS Lett. 2004)
    463. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. (PubMed id 14759373)1 Yusufzai T.M....Felsenfeld G. (Mol. Cell 2004)
    464. Lco1 is a novel widely expressed lamin-binding protein in the nuclear interior. (PubMed id 15265697)1 Vlcek S....Wilson K.L. (Exp. Cell Res. 2004)
    465. Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. (PubMed id 15372542)1 Muchir A....Bonne G. (amp 2004)
    466. Homozygous missense mutation in the lamin A/C gene causes autosomal recessive Hutchinson-Gilford progeria syndrome. (PubMed id 15286156)2 Plasilova M.... Heinimann K. (J. Med. Genet. 2004)
    467. Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome. (PubMed id 15342704)1 Reddel C.J. and Weiss A.S. (J. Med. Genet. 2004)
    468. Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes. (PubMed id 15060110)2 Csoka A.B....Hegele R.A. (J. Med. Genet. 2004)
    469. The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. (PubMed id 12718522)1 StierlAc V....Duband-Goulet I. (Biochemistry 2003)
    470. Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (PubMed id 12729796)1 Bechert K....Osborn M. (Exp. Cell Res. 2003)
    471. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (PubMed id 12534602)1 Tilli C.M....Neumann H.A. (Br. J. Dermatol. 2003)
    472. Mutation analysis of the lamin A/C gene (LMNA) among patients with different cardiomuscular phenotypes. (PubMed id 14684700)2 Vytopil M.... Toniolo D. (J. Med. Genet. 2003)
    473. The strange case of the &quot;lumper&quot; lamin A/C gene and human premature ageing. (PubMed id 13129702)1 Novelli G. and D'Apice M.R. (Trends Mol Med 2003)
    474. Clinical relevance of atrial fibrillation/flutter, stroke, pacemaker implant, and heart failure in Emery-Dreifuss muscular dystrophy: a long-term longitudinal study. (PubMed id 12649505)2 Boriani G....Branzi A. (Stroke 2003)
    475. Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. (PubMed id 12670476)1 Lattanzi G....Maraldi N.M. (Biochem. Biophys. Res. Commun. 2003)
    476. Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene. (PubMed id 14644157)1 Muchir A....Bonne G. (Exp. Cell Res. 2003)
    477. Molecular characterization of protein kinase C-alpha binding to lamin A. (PubMed id 12112001)1 Martelli A.M....Cocco L. (J. Cell. Biochem. 2002)
    478. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1 Andersen J.S.... Lamond A.I. (Curr. Biol. 2002)
    479. Life at the edge: the nuclear envelope and human disease. (PubMed id 12154369)1 Burke B. and Stewart C.L. (Nat. Rev. Mol. Cell Biol. 2002)
    480. Lamin expression in human adipose cells in relation to anatomical site and differentiation state. (PubMed id 11836312)1 Lelliott C.J....Vidal-Puig A. (J. Clin. Endocrinol. Metab. 2002)
    481. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. (PubMed id 11929849)1 Lloyd D.J....Shackleton S. (Hum. Mol. Genet. 2002)
    482. Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. (PubMed id 11801724)1 Mislow J.M.K.... McNally E.M. (J. Cell Sci. 2002)
    483. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    484. Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. (PubMed id 12163176)1 Mislow J.M.... McNally E.M. (FEBS Lett. 2002)
    485. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    486. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. (PubMed id 11953316)1 Ruchaud S....Earnshaw W.C. (EMBO J. 2002)
    487. 1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C. (PubMed id 12018485)1 Krimm I....Zinn-Justin S. (J. Biomol. NMR 2002)
    488. Absence of mutations in exon 8 of the gene in combination antiretroviral therapy-associated partial lipodystrophy. (PubMed id 12138353)1 Domingo P....Vazquez G. (J. Acquir. Immune Defic. Syndr. 2002)
    489. In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C. (PubMed id 12409453)1 Dreuillet C....Ernoult-Lange M. (Nucleic Acids Res. 2002)
    490. Emery-Dreifuss muscular dystrophy. (PubMed id 11973618)1 Helbling-Leclerc A....Schwartz K. (Eur. J. Hum. Genet. 2002)
    491. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. (PubMed id 11691994)1 de Noronha C.M....Greene W.C. (Science 2001)
    492. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. (PubMed id 11331782)1 Zhang D....Lieberman J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    493. The nuclear envelope in muscular dystrophy and cardiovascular diseases. (PubMed id 11576443)1 Burke B....Stewart C.L. (Traffic 2001)
    494. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. (PubMed id 11792811)1 Vigouroux C....Buendia B. (J. Cell. Sci. 2001)
    495. A case of congenital generalized lipodystrophy: metabolic effects of four dietary regimens. Lack of association of CGL with polymorphism in the lamin A/C Gene. (PubMed id 11298098)4 Kazlauskaite R....Wajchenberg B.L. (Clin. Endocrinol. (Oxf) 2001)
    496. Interaction between emerin and nuclear lamins. (PubMed id 11173535)1 Sakaki M....Ishiura S. (J. Biochem. 2001)
    497. Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. (PubMed id 11792821)1 Lee K.K....Wilson K.L. (J. Cell. Sci. 2001)
    498. Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement. (PubMed id 10662742)1 Brodsky G.L....Mestroni L. (Circulation 2000)
    499. The inner nuclear membrane. (PubMed id 10960149)1 Worman H.J. and Courvalin J.C. (J. Membr. Biol. 2000)
    500. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. (PubMed id 10727209)1 Tang K....Honn K.V. (Biochemistry 2000)
    501. Autosomal dominant Emery-Dreifuss dystrophy due to mutations in rod domain of the lamin A/C gene. (PubMed id 10908904)2 Felice K.J.... Grunnet M.L. (Neurology 2000)
    502. Review: nuclear lamins--structural proteins with fundamental functions. (PubMed id 10806082)1 Gruenbaum Y....Cohen M. (J. Struct. Biol. 2000)
    503. Direct interaction between emerin and lamin A. (PubMed id 10673356)1 Clements L....Morris G.E. (Biochem. Biophys. Res. Commun. 2000)
    504. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. (PubMed id 10381623)1 Ohi N.... Nakajima T. (Cell Death Differ. 1999)
    505. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. (PubMed id 9436978)1 Vodicka M.A....Emerman M. (amp 1998)
    506. In vitro interaction of the carboxy-terminal domain of lamin A with actin. (PubMed id 9563518)1 Sasseville A.M. and Langelier Y. (FEBS Lett. 1998)
    507. Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults. (PubMed id 9274531)1 Machiels B.M....Looijenga L.H. (J. Pathol. 1997)
    508. Genetic localization of a newly recognized autosomal dominant limb-girdle muscular dystrophy with cardiac involvement (LGMD1B) to chromosome 1q11-21. (PubMed id 9106535)1 van der Kooi A.J....Bolhuis P.A. (Am. J. Hum. Genet. 1997)
    509. A- and B-type lamins are differentially expressed in normal human tissues. (PubMed id 9243284)1 Broers J.L....Ramaekers F.C. (Histochem. Cell Biol. 1997)
    510. Lamin proteolysis facilitates nuclear events during apoptosis. (PubMed id 8978814)1 Rao L....White E. (J. Cell Biol. 1996)
    511. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    512. Protein-protein interactions between human nuclear lamins expressed in yeast. (PubMed id 7628545)1 Ye Q. and Worman H.J. (Exp. Cell Res. 1995)
    513. A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1. (PubMed id 7951328)1 Kass S....Fishman M.C. (Nat. Genet. 1994)
    514. Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction. (PubMed id 8058329)1 Ozaki T....Sakiyama S. (Oncogene 1994)
    515. The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. (PubMed id 8278403)1 Mancini M.A....Lee W.H. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    516. The processing pathway of prelamin A. (PubMed id 8175923)2 Sinensky M.... Dalton M. (J. Cell Sci. 1994)
    517. LMNA-Related Dilated Cardiomyopathy (PubMed id 20301717)1 Pagon R.A....Stephens K. (1993)
    518. Emery-Dreifuss Muscular Dystrophy (PubMed id 20301609)1 Pagon R.A....Stephens K. (1993)
    519. Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly. (PubMed id 7925482)1 Haas M. and Jost E. (Eur. J. Cell Biol. 1993)
    520. Identification of novel phosphorylation sites in murine A-type lamins. (PubMed id 8477740)1 Eggert M....Jost E. (Eur. J. Biochem. 1993)
    521. Dilated Cardiomyopathy Overview (PubMed id 20301486)1 Pagon R.A....Stephens K. (1993)
    522. Hutchinson-Gilford Progeria Syndrome (PubMed id 20301300)1 Pagon R.A....Stephens K. (1993)
    523. Limb-Girdle Muscular Dystrophy Overview (PubMed id 20301582)1 Pagon R.A....Stephens K. (1993)
    524. Congenital Muscular Dystrophy Overview (PubMed id 20301468)1 Pagon R.A....Stephens K. (1993)
    525. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. (PubMed id 8324822)1 Foisner R. and Gerace L. (Cell 1993)
    526. Charcot-Marie-Tooth Neuropathy Type 2 (PubMed id 20301462)1 Pagon R.A....Stephens K. (1993)
    527. Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. (PubMed id 8344919)1 Lin F. and Worman H.J. (J. Biol. Chem. 1993)
    528. Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. (PubMed id 1602151)1 Dawson S.J. and White L.A. (J. Infect. 1992)
    529. Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. (PubMed id 1667585)1 Clawson G.A....Kumar A. (amp 1991)
    530. Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix. (PubMed id 2406262)1 MA1ller W.E....SchrAPder H.C. (J. Biol. Chem. 1990)
    531. Induction of nuclear lamins A/C in macrophages in in vitro cultures of rat bone marrow precursor cells and human blood monocytes, and in macrophages elicited in vivo by thioglycollate stimulation. (PubMed id 2209722)1 RAPber R.A....Osborn M. (Exp. Cell Res. 1990)
    532. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. (PubMed id 2344612)1 Heald R. and McKeon F. (Cell 1990)
    533. Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells. (PubMed id 2544227)1 MA1ller W.E....SchrAPder H.C. (Biochim. Biophys. Acta 1989)
    534. Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation. (PubMed id 3403563)1 Worman H.J....Georgatos S.D. (J. Biol. Chem. 1988)
    535. Mutations in the LMNA gene encoding lamin A/C. (PubMed id 11102973)9 Genschel J. and Schmidt H.H. (Hum. Mutat. 2000)
    536. Hypertonic-induced lamin A/C synthesis and distribution to nucleoplasmic speckles is mediated by TonEBP/NFAT5 transcriptional activator. (PubMed id 18028879)9 Favale N.O....FernA!ndez Tome M.C. (Biochem. Biophys. Res. Commun. 2007)
    537. Effect of lamin A/C knockdown on osteoblast differentiation and function. (PubMed id 18847334)9 Akter R....Duque G. (J. Bone Miner. Res. 2009)
    538. LMNA mutations in cardiac transplant recipients. (PubMed id 15539782)9 Pethig K....Schmidt H.H. (Cardiology 2005)
    539. Progeroid syndrome with scleroderma-like skin changes associated with homozygous R435C LMNA mutation. (PubMed id 19842191)9 Madej-Pilarczyk A....Hausmanowa-Petrusewicz I. (Am. J. Med. Genet. A 2009)
    540. Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells. (PubMed id 18808171)9 Cenni V....Marmiroli S. (J. Proteome Res. 2008)
    541. Identification of cyclin D3 as a new interaction partner of lamin A/C. (PubMed id 17321498)9 Mariappan I....Parnaik V.K. (Biochem. Biophys. Res. Commun. 2007)
    542. Heart involvement in lamin A/C related diseases. (PubMed id 17067107)9 Ben Yaou R....Bonne G. (Arch Mal Coeur Vaiss 2006)
    543. Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration. (PubMed id 16478798)9 Bakay M....Hoffman E.P. (Brain 2006)
    544. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. (PubMed id 14755334)9 Lammerding J....Lee R.T. (J. Clin. Invest. 2004)
    545. Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. (PubMed id 12898247)9 Verga L....Arbustini E. (Virchows Arch. 2003)
    546. Molecular defects associated with antithrombin deficiency and dilated cardiomyopathy in a Japanese patient. (PubMed id 18480576)9 Fujimori Y....Kojima T. (Intern. Med. 2008)
    547. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. (PubMed id 18396346)9 GaliovA! G....Kozubek S. (Eur. J. Cell Biol. 2008)
    548. Lamin A/C and cardiac diseases. (PubMed id 16601451)9 Sylvius N. and Tesson F. (Curr. Opin. Cardiol. 2006)
    549. Genetics of laminopathies. (PubMed id 15773749)9 Ben Yaou R....Bonne G. (Novartis Found. Symp. 2005)
    550. LMNA mutation position predicts organ system involvement in laminopathies. (PubMed id 15952983)9 Hegele R. (Clin. Genet. 2005)
    551. Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. (PubMed id 15843432)9 Libotte T....Karakesisoglou I. (Mol. Biol. Cell 2005)
    552. Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography. (PubMed id 15475483)9 Taylor M.R....Mestroni L. (J Biomol Screen 2004)
    553. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. (PubMed id 19165338)9 Hamirally S....Coen D.M. (PLoS Pathog. 2009)
    554. Novel LMNA mutation in atypical Werner syndrome presenting with ischemic disease. (PubMed id 19095983)9 Renard D....De Sandre-Giovannoli A. ( a journal of cerebral circulation 2009)
    555. A case of Dunnigan-type familial partial lipodystrophy (FPLD) due to lamin A/C (LMNA) mutations complicated by end-stage renal disease. (PubMed id 19011997)9 Imachi H....Ishida T. (Endocrine 2009)
    556. Severe mandibuloacral dysplasia-associated lipodystrophy and progeria in a young girl with a novel homozygous Arg527Cys LMNA mutation. (PubMed id 18796515)9 Agarwal A.K....Garg A. (J. Clin. Endocrinol. Metab. 2008)
    557. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. (PubMed id 18182166)9 Wolf C.M....Seidman J.G. (J. Mol. Cell. Cardiol. 2008)
    558. Does satellite cell dysfunction contribute to disease progression in Emery-Dreifuss muscular dystrophy? (PubMed id 19021553)9 Gnocchi V.F....Zammit P.S. (Biochem. Soc. Trans. 2008)
    559. Nuclear envelope defects in muscular dystrophy. (PubMed id 16904876)9 Roux K.J. and Burke B. (Biochim. Biophys. Acta 2007)
    560. Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. (PubMed id 17164264)9 Heydemann A....McNally E.M. (Hum. Mol. Genet. 2007)
    561. The retinol acid receptor B gene is hypermethylated in patients with familial partial lipodystrophy. (PubMed id 17556535)9 Cortese R....Brune T. (J. Mol. Endocrinol. 2007)
    562. Compound heterozygosity for mutations in LMNA in a patient with a myopathic and lipodystrophic mandibuloacral dysplasia type A phenotype. (PubMed id 17848409)9 Lombardi F....Novelli G. (J. Clin. Endocrinol. Metab. 2007)
    563. Phenotypic clustering of lamin A/C mutations in neuromuscular patients. (PubMed id 17377071)9 Benedetti S....Previtali S.C. (Neurology 2007)
    564. A LMNA splicing mutation in two sisters with severe Dunnigan-type familial partial lipodystrophy type 2. (PubMed id 16636128)9 Morel C.F....Hegele R.A. (J. Clin. Endocrinol. Metab. 2006)
    565. A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. (PubMed id 16671095)9 Denecke J....Marquardt T. (Hum. Mutat. 2006)
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    575. Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression. (PubMed id 10364436)9 Pierce T....Holy J. (Exp. Neurol. 1999)
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    580. Silencing lamin A/C in human endometrial stromal cells: a model to investigate endometrial gene function and regulation. (PubMed id 15347737)9 Tulac S....Giudice L.C. (Mol. Hum. Reprod. 2004)
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    582. Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. (PubMed id 14600514)9 Caron M....Capeau J. (AIDS 2003)
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    591. Desmin immunolocalisation in autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 17329105)9 Piercy R.J....Brown S.C. (Neuromuscul. Disord. 2007)
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    606. Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. (PubMed id 19556978)9 Ahmed M....Karpe F. (Obesity (Silver Spring) 2010)
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    701. Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. (PubMed id 16949164)9 Nakamura M....Toda T. (Biochim. Biophys. Acta 2006)
    702. Laminopathies: multisystem dystrophy syndromes. (PubMed id 16364671)9 Jacob K.N. and Garg A. (Mol. Genet. Metab. 2006)
    703. Myofibrillar myopathy with congenital cataract and skeletal anomalies without mutations in the desmin, alphaB-crystallin, myotilin, LMNA or SEPN1 genes. (PubMed id 17005401)9 Kostera-Pruszczyk A....Fidzianska A. (Neuromuscul. Disord. 2006)
    704. X-linked form of Emery-Dreifuss muscular dystrophy. (PubMed id 16550925)9 Hayashi Y.K. (Acta Myol 2005)
    705. Hepatic steatosis in Dunnigan-type familial partial lipodystrophy. (PubMed id 16181372)9 LA1dtke A....Schmidt H.H. (Am. J. Gastroenterol. 2005)
    706. Nuclear envelopathies--raising the nuclear veil. (PubMed id 15817509)9 Somech R....Simon A.J. (Pediatr. Res. 2005)
    707. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. (PubMed id 16014412)9 Yang S.H....Fong L.G. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    708. Components of the nuclear envelope and their role in human disease. (PubMed id 15773746)9 Worman H.J. (Novartis Found. Symp. 2005)
    709. A-type lamin-linked lipodystrophies. (PubMed id 15773753)9 Vigouroux C. and Capeau J. (Novartis Found. Symp. 2005)
    710. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. (PubMed id 16247757)9 Taylor M.R.... Mestroni L. (Hum. Mutat. 2005)
    711. HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. (PubMed id 16184025)9 Kudlow B.A....Kennedy B.K. (AIDS 2005)
    712. A new LMNA mutation causing limb girdle muscular dystrophy 1B. (PubMed id 15789136)9 Spuler S....Schmidt H. (J. Neurol. 2005)
    713. Genetic and physiological insights into the metabolic syndrome. (PubMed id 15890790)9 Hegele R.A. and Pollex R.L. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005)
    714. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. (PubMed id 16186497)9 Mallampalli M.P....Michaelis S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    715. Altered pre-lamin A processing is a common mechanism leading to lipodystrophy. (PubMed id 15843404)9 Capanni C....Lattanzi G. (Hum. Mol. Genet. 2005)
    716. Gene mutations in adult Japanese patients with dilated cardiomyopathy. (PubMed id 15671604)9 Shimizu M....Mabuchi H. (Circ. J. 2005)
    717. Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. (PubMed id 16199031)9 Kivinen K....Taimen P. (Exp. Cell Res. 2005)
    718. Phenotypic heterogeneity in body fat distribution in patients with atypical Werner's syndrome due to heterozygous Arg133Leu lamin A/C mutation. (PubMed id 16174718)9 Jacob K.N....Garg A. (J. Clin. Endocrinol. Metab. 2005)
    719. A-type nuclear lamins, progerias and other degenerative disorders. (PubMed id 15722103)9 Smith E.D....Kennedy B.K. (Mech. Ageing Dev. 2005)
    720. Identification of differentially expressed proteins in oral squamous cell carcinoma using a global proteomic approach. (PubMed id 15942644)9 Koike H....Tanzawa H. (Int. J. Oncol. 2005)
    721. [Monogenic severe insulin resistance syndromes]. (PubMed id 15908053)9 Vincent-Desplanques D....Vantyghem M.C. (Rev Med Interne 2005)
    722. [Laminopathies: lipodystrophies, insulin resistance, syndromes of accelerated ageing... and others]. (PubMed id 15988390)9 Vigouroux C. (Ann. Endocrinol. (Paris) 2005)
    723. Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome. (PubMed id 15756215)9 Gordon L.B....Lichtenstein A.H. (J. Pediatr. 2005)
    724. Extreme variability of skeletal and cardiac muscle involvement in patients with mutations in exon 11 of the lamin A/C gene. (PubMed id 15770669)9 Mercuri E....Muntoni F. (amp 2005)
    725. Sequestration of pRb by cyclin D3 causes intranuclear reorganization of lamin A/C during muscle cell differentiation. (PubMed id 15703219)9 Mariappan I. and Parnaik V.K. (Mol. Biol. Cell 2005)
    726. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. (PubMed id 16079796)9 Varela I....LA^pez-OtA-n C. (Nature 2005)
    727. Differential protein expression in anatomical zones of the prostate. (PubMed id 15892163)9 Lexander H....Egevad L. (Proteomics 2005)
    728. Diseases of adipose tissue: genetic and acquired lipodystrophies. (PubMed id 16246048)9 Capeau J....Bastard J.P. (Biochem. Soc. Trans. 2005)
    729. Electrophysiological and histopathological characteristics of progressive atrioventricular block accompanied by familial dilated cardiomyopathy caused by a novel mutation of lamin A/C gene. (PubMed id 15720451)9 Otomo J....Shirato K. (J. Cardiovasc. Electrophysiol. 2005)
    730. Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy. (PubMed id 15773758)9 Kozlov S....Stewart C.L. (Novartis Found. Symp. 2005)
    731. Molecular etiopathogenesis of limb girdle muscular and congenital muscular dystrophies: boundaries and contiguities. (PubMed id 16002060)9 Guglieri M....Comi G.P. ( international journal of clinical chemistry 2005)
    732. [Familial dilated cardiomyopathy]. (PubMed id 16170685)9 Osterziel K.J....Perrot A. (Herz 2005)
    733. Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. (PubMed id 16208517)9 Huang S....Oshima J. (Hum. Genet. 2005)
    734. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. (PubMed id 16046620)9 Filesi I....Novelli G. (Physiol. Genomics 2005)
    735. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. (PubMed id 15750600)9 Scaffidi P. and Misteli T. (Nat. Med. 2005)
    736. Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. (PubMed id 16261260)9 Columbaro M....Lattanzi G. (Cell. Mol. Life Sci. 2005)
    737. Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone. (PubMed id 16241930)9 LA1dtke A....Schmidt H.H. (Diabet. Med. 2005)
    738. Patients with familial partial lipodystrophy of the Dunnigan type due to a LMNA R482W mutation show muscular and cardiac abnormalities. (PubMed id 15531479)9 Vantyghem M.C....Vigouroux C. (J. Clin. Endocrinol. Metab. 2004)
    739. Hutchinson-Gilford progeria syndrome. (PubMed id 15479179)9 Pollex R.L. and Hegele R.A. (Clin. Genet. 2004)
    740. Cytoskeletal influences on nuclear shape in granulocytic HL-60 cells. (PubMed id 15317658)9 Olins A.L. and Olins D.E. (BMC Cell Biol. 2004)
    741. Aging and nuclear organization: lamins and progeria. (PubMed id 15145358)9 Mounkes L.C. and Stewart C.L. (Curr. Opin. Cell Biol. 2004)
    742. Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina. (PubMed id 15292200)9 Panorchan P....Tseng Y. (J. Biol. Chem. 2004)
    743. Laminopathies: from the heart of the cell to the clinics. (PubMed id 15367859)9 Benedetti S. and Merlini L. (Curr. Opin. Neurol. 2004)
    744. Disruption of spermatogenesis in mice lacking A-type lamins. (PubMed id 14996939)9 Alsheimer M....Benavente R. (J. Cell. Sci. 2004)
    745. Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. (PubMed id 15053843)9 Reichart B....Dabauvalle M.C. (BMC Cell Biol. 2004)
    746. Gene expression profiling of fibroblasts from a human progeroid disease (mandibuloacral dysplasia, MAD #248370) through cDNA microarrays. (PubMed id 15473259)9 Amati F....Novelli G. (Gene Expr. 2004)
    747. Mesangiocapillary glomerulonephritis type 2 associated with familial partial lipodystrophy (Dunnigan-Kobberling syndrome). (PubMed id 14988595)9 Owen K.R....Bingham C. (Nephron Clin Pract 2004)
    748. Abnormal cell cycle regulation in primary human uveal melanoma cultures. (PubMed id 15660415)9 Pardo M....Capeans C. (J. Cell. Biochem. 2004)

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    Entrez Gene: 4000 HGNC: 6636 AceView: LMNA Ensembl:ENSG00000160789 euGenes: HUgn4000
    ECgene: LMNA Kegg: 4000 H-InvDB: LMNA

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LMNA Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for LMNA Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LMNA[genesymbol]

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