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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMNA Gene

protein-coding   GIFtS: 74
GCID: GC01P156053

Lamin A/C

(Previous names: cardiomyopathy, dilated 1A (autosomal dominant), limb girdle...)
(Previous symbols: LMN1, CMD1A, LGMD1B, PRO1, LMNL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lamin A/C1 2     70 KDa Lamin2
LMN11 2 3 5     CDCD12
CMD1A1 2 5     CDDC2
LGMD1B1 2 5     CMT2B12
LMNL11 2     FPL2
PRO11 2     FPLD22
Lamin A/C-Like 11 2     IDC2
EMD22 5     LDP12
FPLD2 5     LFP2
HGPS2 5     LMNC2
Cardiomyopathy, Dilated 1A (Autosomal Dominant)1     lamin2
Limb Girdle Muscular Dystrophy 1B (Autosomal Dominant)1     prelamin-A/C2
Progeria 1 (Hutchinson-Gilford Type)1     Renal Carcinoma Antigen NY-REN-322

External Ids:    HGNC: 66361   Entrez Gene: 40002   Ensembl: ENSG000001607897   OMIM: 1503305   UniProtKB: P025453   

Export aliases for LMNA gene to outside databases

Previous GC identifers: GC01P153921 GC01P151817 GC01P152830 GC01P153301 GC01P152897 GC01P154318 GC01P127446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMNA Gene:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.
The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina
matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be
involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A
and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several
diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy,
dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. (provided by
RefSeq, Apr 2012)

GeneCards Summary for LMNA Gene: 
LMNA (lamin A/C) is a protein-coding gene. Diseases associated with LMNA include progeria, and dilated cardiomyopathy, and among its related super-pathways are Apoptosis and survival FAS signaling cascades and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include protein binding and structural molecule activity. An important paralog of this gene is LMNB1.

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics
Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
senescence

Gene Wiki entry for LMNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMNA gene promoter:
         STAT1   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMNA promoter sequence
   Search SABiosciences Chromatin IP Primers for LMNA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

LMNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156053:  view genomic region     (about GC identifiers)

Start:
156,052,364 bp from pter      End:
156,109,880 bp from pter
Size:
57,517 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545 (See protein sequence)
Recommended Name: Prelamin-A/C precursor  
Size: 664 amino acids; 74139 Da
Subunit: Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1
and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43 (By similarity). Proteolytically processed
isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP; may
regulate MLIP localization to the nucleus envelope. Interacts with DMPK; may regulate nuclear envelope stability
Subcellular location: Nucleus. Nucleus envelope. Note=Farnesylation of prelamin-A/C facilitates nuclear envelope
targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C,
which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated
prelamin-A/C
Miscellaneous: There are three types of lamins in human cells: A, B, and C
Miscellaneous: The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the
disintegration and formation of the nuclear envelope in prophase and telophase, respectively
Sequence caution: Sequence=CAA27173.1; Type=Frameshift; Positions=582;
6/8 PDB 3D structures from and Proteopedia for LMNA (see all 8):
1IFR (3D)        1IVT (3D)        1X8Y (3D)        2XV5 (3D)        3GEF (3D)        3V4Q (3D)    
Secondary accessions: B4DI32 D3DVB0 E7EUI9 P02546 Q5TCJ2 Q5TCJ3 Q969I8 Q96JA2
Alternative splicing: 4 isoforms:  P02545-1   P02545-2   P02545-3   P02545-4   (No experimental confirmation available. Ref.3 (BAG58344) sequence is in conflict in position: 556:G->R)

Explore the universe of human proteins at neXtProt for LMNA: NX_P02545

Explore proteomics data for LMNA at MOPED 

Post-translational modifications:

  • UniProtKB: Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in
    regulating lamin associations
  • UniProtKB: Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The
    prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the
    last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15
    C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these
    blocks cleavage
  • UniProtKB: Sumoylation is necessary for the localization to the nuclear envelope
  • UniProtKB: Farnesylation of prelamin-A/C facilitates nuclear envelope targeting
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02545

  • LMNA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMNA Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001244303.1  NP_001269553.1  NP_001269554.1  NP_001269555.1  NP_005563.1  NP_733821.1  NP_733822.1  

    ENSEMBL proteins: 
     ENSP00000357284   ENSP00000357283   ENSP00000357282   ENSP00000395597   ENSP00000424518  
     ENSP00000357280   ENSP00000426535   ENSP00000421821   ENSP00000424977   ENSP00000292304  
     ENSP00000355292   ENSP00000376164  
    Reactome Protein details: P02545
    Human Recombinant Protein Products for LMNA: 
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    OriGene Purified Proteins for LMNA
    OriGene Protein Over-expression Lysate for LMNA
    OriGene MassSpec for LMNA 
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    GenScript Custom Purified and Recombinant Proteins Services for LMNA
    Novus Biologicals LMNA Protein
    Novus Biologicals LMNA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LMNA
    Cloud-Clone Corp. Proteins for LMNA 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS3453101
    GO:0005638lamin filament TAS10080180
    GO:0005652nuclear lamina TAS8344919
    GO:0005654nucleoplasm TAS--

    LMNA for ontologies           About GeneDecksing



    LMNA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LMNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for LMNA  (lamin A/C)
    OriGene Antibodies for LMNA
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    Novus Biologicals LMNA Antibodies
    Abcam antibodies for LMNA
    Cloud-Clone Corp. Antibodies for LMNA 
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    LSBio Antibodies in human, mouse, rat for LMNA 

    Assay Products for LMNA: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMNA 
    Cloud-Clone Corp. CLIAs for LMNA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IFF5: Intermediate filaments type V, lamins

    4 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR016044 F
     IPR001322 Lamin_tail_dom

    Graphical View of Domain Structure for InterPro Entry P02545

    ProtoNet protein and cluster: P02545

    2 Blocks protein domains:
    IPB001322 Intermediate filament
    IPB001664 Intermediate filament protein


    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Similarity: Belongs to the intermediate filament family


    LMNA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMNA_HUMAN, P02545
    Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner
    nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with
    chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in
    nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics
    Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA
    damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature
    senescence

         Genatlas biochemistry entry for LMNA:
    lamin,types A and C,common gene,alternatively spliced isoforms

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS3453101
    GO:0005515protein binding IPI10381623
         
    LMNA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LMNA:
     Increased S DNA content  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         15/25 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Lmna) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    LMNA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LMNA: Lmnatm6Lgf Lmnatm1Stw Lmnatm4Lgf Lmnatm5Lgf Lmnatm1Lgf Lmnatm2Lgf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMNA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMNA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMNA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMNA 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMNA
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate LMNA (see all 15):
    hsa-miR-3163 hsa-miR-548d-3p hsa-miR-222* hsa-miR-767-5p hsa-miR-16-1* hsa-miR-548aa hsa-miR-221* hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidLMNA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
    Products:
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    Sirion Biotech Validated adenovirus to knockdown LMNA in human, mouse 
                         Customized adenovirus for overexpression of LMNA

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for LMNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LMNA (NM_170707)
    Sino Biological Human cDNA Clone for LMNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Sirion Biotech Customized lentivirus for stable overexpression of LMNA 
                         Customized lentivirus expression plasmids for stable overexpression of LMNA 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LMNA About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Mitotic Metaphase and Anaphase0.94
    Mitotic M-M/G1 phases0.88
    4Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    5Initiation of Nuclear Envelope Reformation
    Initiation of Nuclear Envelope Reformation0.69
    Nuclear Envelope Reassembly0.69
    Clearance of Nuclear Envelope Membranes from Chromatin0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LMNA
        Caspase Cascade
    Granzyme Pathway
    Fas Signaling

    3 Cell Signaling Technology (CST) Pathways for LMNA
        Apoptosis and Autophagy
    Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for LMNA
        Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades

    4 BioSystems Pathways for LMNA
        Adipogenesis
    FAS pathway and Stress induction of HSP regulation
    Arrhythmogenic right ventricular cardiomyopathy
    Caspase cascade in apoptosis


    5/22        Reactome Pathways for LMNA (see all 22)
        Initiation of Nuclear Envelope Reformation
    Clearance of Nuclear Envelope Membranes from Chromatin
    Cell Cycle
    M Phase
    Apoptosis

    1 PharmGKB Pathway for LMNA
        Antiarrhythmic Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for LMNA):
        Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy


    LMNA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LMNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/964 Interacting proteins for LMNA (P025451, 2, 3 ENSP000003572834) via UniProtKB, MINT, STRING, and/or I2D (see all 964)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI32, 3, ENSP000003854794MINT-7893990 MINT-7893924 MINT-7894005 MINT-7894023 MINT-7893941 MINT-7894038 I2D: score=1 STRING: ENSP00000385479
    DDX39BQ138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0006997nucleus organization ----

    LMNA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LMNA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMNA

    10/18 Novoseek inferred chemical compound relationships for LMNA gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nelfinavir 23.7 2 14600514 (1), 18344876 (1)
    rosiglitazone 18 2 14510863 (2)
    indinavir 17.1 4 14600514 (1), 16184025 (1), 12844477 (1)
    zinc 14.2 12 16278265 (1), 19494770 (1), 19323649 (1), 15998779 (1) (see all 7)
    retinoic acid 12.4 18 15219855 (3), 10694499 (3), 12844477 (2), 11478838 (1) (see all 8)
    deoxyribonucleic acid 6.22 1 12015247 (1)
    calcium 0.975 2 1467310 (1), 19144047 (1)
    cholesterol 0 4 11136544 (1), 12524233 (1), 17994215 (1), 15205219 (1)
    atp 0 6 1965140 (2), 15892163 (1), 2004657 (1)
    lipid 0 3 20130076 (2), 16181372 (1)

    Search CenterWatch for drugs/clinical trials and news about LMNA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for LMNA gene (7 alternative transcripts): 
    NM_001257374.2  NM_001282624.1  NM_001282625.1  NM_001282626.1  NM_005572.3  NM_170707.3  NM_170708.3  

    Unigene Cluster for LMNA:

    Lamin A/C
    Hs.594444  [show with all ESTs]
    Unigene Representative Sequence: NM_170707
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000502751 ENST00000368301(uc001fnf.1) ENST00000495341 ENST00000470835
    ENST00000515711 ENST00000368300(uc001fng.2 uc001fni.2 uc009wro.1 uc001fnk.2)
    ENST00000478063 ENST00000470199 ENST00000469565 ENST00000368299 ENST00000502357
    ENST00000448611(uc010pgz.1) ENST00000515459 ENST00000368297 ENST00000504687
    ENST00000473598 ENST00000515824 ENST00000496738(uc001fnj.2 uc010pha.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMNA
    Sirion Biotech Customized lentivirus for stable overexpression of LMNA 
                         Customized lentivirus expression plasmids for stable overexpression of LMNA 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMNA

    Additional mRNA sequence: 

    AF381029.1 AK026584.1 AK056143.1 AK056191.1 AK057997.1 AK097801.1 AK098128.1 AK122732.1 
    AK130179.1 AK294217.1 AK295390.1 AK309539.1 AY357727.1 AY528714.1 AY847595.1 AY847596.1 
    AY847597.1 BC000511.2 BC003162.1 BC014507.1 BC018863.2 BC033088.1 M13451.1 M13452.1 
    NR_047544.1 NR_047545.1 X03444.1 X03445.1 

    24/79 DOTS entries (see all 79):

    DT.100891747  DT.91871177  DT.92469899  DT.95246279  DT.100891714  DT.95294580  DT.100891710  DT.121347135 
    DT.92469913  DT.100891740  DT.100891733  DT.92057489  DT.101986435  DT.121347131  DT.121347084  DT.100891726 
    DT.99987681  DT.95322263  DT.100039687  DT.121347143  DT.121347120  DT.100891698  DT.100891751  DT.320389 

    24/1597 AceView cDNA sequences (see all 1597):

    BQ899088 CR626536 BE383355 CD367718 CA423881 BM560647 BQ934954 H13874 
    BG059624 AK056191 CA405830 AI654262 BQ219808 BU838224 BQ933470 BQ929963 
    BG749019 CB123672 BQ949807 T75500 BE741126 BQ777189 CA454200 BQ958754 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LMNA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                            -                                   -                                 
    SP2:                                            -                                   -           -                     
    SP3:                                            -                                                                     
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for LMNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMNA expression in normal human tissues (normalized intensities)      LMNA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGGGCT
    LMNA Expression
    About this image


    LMNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/38 selected tissues (see all 38) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd14+ cells   
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Primary Oocyte Primary Follicle
             Secondary follicles
             ovary ; follicle cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See LMNA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMNA

    SOURCE GeneReport for Unigene cluster: Hs.594444

    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
    Tissue specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is
    prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions,
    where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and
    disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of
    ZMPSTE24/FACE1 in response to oxidative stress

        SABiosciences Expression via Pathway-Focused PCR Arrays including LMNA: 
              TNF Ligands & Receptors in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMNA
    OriGene qSTAR qPCR primer pairs in human, mouse for LMNA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LMNA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMNA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMNA gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmna1 , 5 lamin A1, 5 90.3(n)1
    96.83(a)1
      3 (38.84 cM)5
    169051  NM_001002011.21  NP_001002011.21 
     884811485 
    chicken
    (Gallus gallus)
    Aves LMNA6
    lamin A/C
    47(a)
    1 ↔ 1
    10(10954013-10971823)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    68(a)
    53(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL344336.1(6444-21018)
    2(41214999-41216574)
    African clawed frog
    (Xenopus laevis)
    Amphibia lmna-A2 lamin A/C 76.67(n)    X06345.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lmna2 lamin A 76.11(n)   195815  AF397016.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LamC3 nuclear envelope reassembly 37(a)
    (best of 2)
      51B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea lmn-13 Intermediate filament proteins (2
    domains)
    30(a)
    (best of 5)
      I(8771116-8773244)   --


    ENSEMBL Gene Tree for LMNA (if available)
    TreeFam Gene Tree for LMNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMNA gene
    LMNB12  VIM2  INA2  PRPH2  NEFM2  DES2  LMNB22  NEFH2  
    GFAP2  
    5 SIMAP similar genes for LMNA using alignment to 9 protein entries:     LMNA_HUMAN (see all proteins):
    LMNB1    LMNB2    VIM    KRT5    keratin

    LMNA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1420 SNPs in LMNA are shown (see all 1420)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0099894
    Lipodystrophy, familial partial, 2 (FPLD2)4--see VAR_0099892 G D mis40--------
    VAR_0397884
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0397882 R S mis40--------
    VAR_0397784
    Lipodystrophy, familial partial, 2 (FPLD2)4--see VAR_0397782 R C mis40--------
    VAR_0635914
    Muscular dystrophy congenital LMNA-related (MDCL)4--see VAR_0635912 L S mis40--------
    VAR_0099804
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0099802 R Q mis40--------
    VAR_0397914
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0397912 R H mis40--------
    VAR_0397874
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0397872 R H mis40--------
    VAR_0162054
    Limb-girdle muscular dystrophy 1B (LGMD1B)4--see VAR_0162052 R H mis40--------
    VAR_0649704
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0649702 E K mis40--------
    VAR_0397634
    Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2)4--see VAR_0397632 R Q mis40--------

    HapMap Linkage Disequilibrium report for LMNA (156052364 - 156109880 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LMNA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489


    Human Gene Mutation Database (HGMD): LMNA

    Locus Specific Mutation Databases (LSDB): LMNA
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LMNA
    DNA2.0 Custom Variant and Variant Library Synthesis for LMNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 150330   
    OMIM disorders: 181350  115200  151660  605588  159001  248370  176670  275210  610140  
    UniProtKB/Swiss-Prot: LMNA_HUMAN, P02545
  • Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Emery-Dreifuss muscular dystrophy 3, autosomal recessive (EDMD3) [MIM:181350]: A form of Emery-Dreifuss
    muscular dystrophy, a degenerative myopathy characterized by weakness and atrophy of muscle without involvement
    of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy
    associated with cardiac conduction defects. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Cardiomyopathy, dilated 1A (CMD1A) [MIM:115200]: A disorder characterized by ventricular dilation and
    impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of
    premature death. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lipodystrophy, familial partial, 2 (FPLD2) [MIM:151660]: A disorder characterized by the loss of
    subcutaneous adipose tissue in the lower parts of the body (limbs, buttocks, trunk). It is accompanied by an
    accumulation of adipose tissue in the face and neck causing a double chin, fat neck, or cushingoid appearance.
    Adipose tissue may also accumulate in the axillae, back, labia majora, and intraabdominal region. Affected
    patients are insulin-resistant and may develop glucose intolerance and diabetes mellitus after age 20 years,
    hypertriglyceridemia, and low levels of high density lipoprotein cholesterol. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Limb-girdle muscular dystrophy 1B (LGMD1B) [MIM:159001]: An autosomal dominant degenerative myopathy with
    age-related atrioventricular cardiac conduction disturbances, dilated cardiomyopathy, and the absence of early
    contractures. Characterized by slowly progressive skeletal muscle weakness of the hip and shoulder girdles.
    Muscle biopsy shows mild dystrophic changes. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Charcot-Marie-Tooth disease 2B1 (CMT2B1) [MIM:605588]: A recessive axonal form of Charcot-Marie-Tooth
    disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy,
    initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is
    classified in two main groups on the basis of electrophysiologic properties and histopathology: primary
    peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral
    axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in
    the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and
    progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hutchinson-Gilford progeria syndrome (HGPS) [MIM:176670]: Rare genetic disorder characterized by features
    reminiscent of marked premature aging. Note=The disease is caused by mutations affecting the gene represented in
    this entry. HGPS is caused by the toxic accumulation of a mutant form of lamin-A/C. This mutant protein, called
    progerin, acts to deregulate mitosis and DNA damage signaling, leading to premature cell death and senescence.
    Progerin lacks the conserved ZMPSTE24/FACE1 cleavage site and therefore remains permanently farnesylated. Thus,
    although it can enter the nucleus and associate with the nuclear envelope, it cannot incorporate normally into
    the nuclear lamina
  • Cardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH) [MIM:212112]: A disorder
    characterized by the association of genital anomalies, hypergonadotropic hypogonadism and dilated cardiomyopathy.
    Patients can present other variable clinical manifestations including mental retardation, skeletal anomalies,
    scleroderma-like skin, graying and thinning of hair, osteoporosis. Dilated cardiomyopathy is characterized by
    ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mandibuloacral dysplasia with type A lipodystrophy (MADA) [MIM:248370]: A disorder characterized by
    mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, progeroid
    appearance, partial alopecia, soft tissue calcinosis, joint contractures, and partial lipodystrophy with loss of
    subcutaneous fat from the extremities. Adipose tissue in the face, neck and trunk is normal or increased.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Lethal tight skin contracture syndrome (LTSCS) [MIM:275210]: Rare disorder mainly characterized by
    intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and
    epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent
    eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia,
    multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first
    week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Heart-hand syndrome Slovenian type (HHS-Slovenian) [MIM:610140]: Heart-hand syndrome (HHS) is a
    clinically and genetically heterogeneous disorder characterized by the co-occurrence of a congenital cardiac
    disease and limb malformations. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Muscular dystrophy congenital LMNA-related (MDCL) [MIM:613205]: A form of congenital muscular dystrophy.
    Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with
    joint contractures. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/130 diseases for LMNA (see all 130):    About MalaCards
    progeria    dilated cardiomyopathy    emery-dreifuss muscular dystrophy    familial partial lipodystrophy
    atypical werner syndrome    emery-dreifuss muscular dystrophy, ad    heart-hand syndrome, slovenian type    limb-girdle muscular dystrophy, type 1b
    charcot-marie-tooth neuropathy type 2b1    emery-dreifuss muscular dystrophy, ar    lmna-related emery-dreifuss muscular dystrophy, autosomal    progeroid laminopathies
    lmna-related dilated cardiomyopathy    familial partial lipodystrophy, kobberling type    autosomal codominant severe lipodystrophic laminopathy    laminopathy type decaudain-vigouroux
    lipodystrophy, familial partial, type 2    progeria-associated arthropathy    dilated cardiomyopathy with quadriceps myopathy    lmna-related muscle diseases

    9 diseases from the University of Copenhagen DISEASES database for LMNA:
    Progeria     Lipodystrophy     Dilated cardiomyopathy     Myopathy
    Neuropathy     Congenital heart block     Werner syndrome     Acanthosis nigricans
    Genetic disorder

    LMNA for disorders           About GeneDecksing

    10/73 Novoseek inferred disease relationships for LMNA gene (see all 73)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipodystrophy, familial partial 97.8 88 12015247 (3), 11397881 (2), 18364375 (2), 19622949 (2) (see all 63)
    progeria 97 77 15479179 (2), 17076270 (2), 16671095 (2), 17469202 (2) (see all 59)
    muscular dystrophy emery-dreifuss 96.5 48 19589462 (2), 16697197 (2), 12685553 (1), 20225280 (1) (see all 41)
    emery-dreifuss muscular dystrophy, autosomal dominant 96.4 21 11532159 (1), 10587585 (1), 11102973 (1), 15639119 (1) (see all 19)
    lgmd1b 95.4 28 10814726 (4), 15678000 (3), 19070492 (2), 15668447 (1) (see all 15)
    mandibuloacral dysplasia 95.3 25 16278265 (2), 16046620 (1), 16364671 (1), 15843404 (1) (see all 16)
    partial lipodystrophy 93.2 32 15817509 (1), 11102973 (1), 12524233 (1), 15773753 (1) (see all 26)
    lipodystrophy 90 59 18077842 (3), 11078466 (2), 12788894 (2), 12844477 (2) (see all 37)
    acroosteolysis 86.4 4 16278265 (1), 17848409 (1), 18554282 (1)
    lipodystrophy, congenital generalized 85.4 4 19169477 (1), 19494770 (1), 14516935 (1)

    GeneTests: LMNA
    GeneReviews: LMNA
    Genetic Association Database (GAD): LMNA
    Human Genome Epidemiology (HuGE) Navigator: LMNA (37 documents)

    Export disorders for LMNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMNA gene, integrated from 9 sources (see all 799) (see top 10):
    (articles sorted by number of sources associating them with LMNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expanding the phenotype of LMNA mutations in dilated cardiomyopathy and functional consequences of these mutations. (PubMed id 12920062)1, 2, 4, 9 Sebillon P.... Komajda M. (2003)
    2. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. (PubMed id 15219508)1, 2, 4, 9 Hermida-Prieto M....Crespo-Leiro M. (2004)
    3. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). (PubMed id 12768443)1, 2, 9 Cao H. and Hegele R.A. (2003)
    4. Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. (PubMed id 17327460)1, 4, 9 Owen K.R....McCarthy M.I. (2007)
    5. Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. (PubMed id 18585512)1, 4, 9 Parks S.B....Hershberger R.E. (2008)
    6. Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease. (PubMed id 11897440)1, 2, 9 Arbustini E....Tavazzi L. (2002)
    7. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. (PubMed id 17327461)1, 4, 9 Mesa J.L....Barroso I. (2007)
    8. Variation in the lamin A/C gene: associations with metabolic syndrome. (PubMed id 15205219)1, 4, 9 Steinle N.I....Shuldiner A.R. (2004)
    9. LMNA mutations in atypical Werner's syndrome. (PubMed id 12927431)1, 2, 9 Chen L.... Oshima J. (2003)
    10. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. (PubMed id 12628721)1, 2, 9 Taylor M.R.G.... Mestroni L. (2003)
    11. Novel and recurrent mutations in lamin A/C in patients with Emery- Dreifuss muscular dystrophy. (PubMed id 11503164)1, 2, 9 Brown C.A.... Spence J.E. (2001)
    12. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. (PubMed id 10655060)1, 2, 9 Shackleton S.... Trembath R.C. (2000)
    13. Mutations in the LMNA gene do not cause axonal CMT in Czech patients. (PubMed id 19424285)1, 4, 9 LaA!A!uthovA! P....Seeman P. (2009)
    14. Validation of high-resolution DNA melting analysis for mutation scanning of the LMNA gene. (PubMed id 19318026)1, 4, 9 Millat G....Rousson R. (2009)
    15. Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids. (PubMed id 17994215)1, 4, 9 Duesing K....Gibson F. (2008)
    16. Collagen expression in fibroblasts with a novel LMNA mutation. (PubMed id 17150192)1, 2, 9 Nguyen D....Oshima J. (2007)
    17. Mutations of the LMNA gene can mimic autosomal dominant proximal spinal muscular atrophy. (PubMed id 17136397)1, 2, 9 Rudnik-Schoeneborn S.... Zerres K. (2007)
    18. Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. (PubMed id 11799477)1, 2, 9 De Sandre-Giovannoli A.... Levy N. (2002)
    19. An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese. (PubMed id 12145775)1, 4, 9 Murase Y....Mabuchi H. (2002)
    20. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). (PubMed id 10814726)1, 2, 9 Muchir A.... Schwartz K. (2000)
    21. Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation. (PubMed id 19427440)1, 4, 9 Brauch K.M....Olson T.M. (2009)
    22. In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients. (PubMed id 16061563)1, 2, 9 Sylvius N.... Tesson F. (2005)
    23. Aging syndrome genes and premature coronary artery disease. (PubMed id 16262891)1, 4, 9 Low A.F....MacRae C.A. (2005)
    24. Functional consequences of an LMNA mutation associated with a new cardiac and non-cardiac phenotype. (PubMed id 12673789)1, 2, 9 Charniot J.-C.... Komajda M. (2003)
    25. Subcutaneous abdominal adipocyte size, a predictor of type 2 diabetes, is linked to chromosome 1q21--q23 and is associated with a common polymorphism in LMNA in Pima Indians. (PubMed id 11243729)1, 4, 9 Weyer C....Pratley R.E. (2001)
    26. p.S143F mutation in lamin A/C: a new phenotype combining myopathy and progeria. (PubMed id 15622532)1, 2, 9 Kirschner J....Korinthenberg R. (2005)
    27. Analysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians. (PubMed id 11440372)1, 4, 9 Wolford J.K....Prochazka M. (2001)
    28. Different mutations in the LMNA gene cause autosomal dominant and autosomal recessive Emery-Dreifuss muscular dystrophy. (PubMed id 10739764)1, 2, 9 Raffaele di Barletta M.... Toniolo D. (2000)
    29. De novo LMNA mutations cause a new form of congenital muscular dystrophy. (PubMed id 18551513)1, 2, 9 Quijano-Roy S....Estournet B. (2008)
    30. Increased plasticity of the nuclear envelope and hype rmobility of telomeres due to the loss of A-type lamins. (PubMed id 20079404)1, 2, 9 De Vos W.H....Van Oostveldt P. (2010)
    31. Prelamin A acts to accelerate smooth muscle cell sene scence and is a novel biomarker of human vascular aging. (PubMed id 20458013)1, 2, 9 Ragnauth C.D....Shanahan C.M. (2010)
    32. Polymorphisms of the lamina maturation pathway and th eir association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4, 9 Fontaine-Bisson B....Morange P.E. (2010)
    33. Emerin-prelamin A interplay in human fibroblasts. (PubMed id 19323649)1, 2, 9 Capanni C....Lattanzi G. (2009)
    34. Ovarian failure and dilated cardiomyopathy due to a novel lamin mutation. (PubMed id 19283854)1, 2, 9 McPherson E....Giampietro P.F. (2009)
    35. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4, 9 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    36. The role of genetic variation in the Lamin A/C gene in the etiology of Polycystic Ovary Syndrome. (PubMed id 19401371)1, 4, 9 Urbanek M....Dunaif A. (2009)
    37. Heart-hand syndrome of Slovenian type: a new kind of laminopathy. (PubMed id 18611980)1, 2, 9 Renou L.... Bonne G. (2008)
    38. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. (PubMed id 17327437)1, 4, 9 Wegner L....Pedersen O. (2007)
    39. A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia. (PubMed id 15998779)1, 2, 9 Garg A.... Agarwal A.K. (2005)
    40. Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? (PubMed id 15551023)1, 4, 9 van Berlo J.H....Pinto Y.M. (2005)
    41. Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins. (PubMed id 15476822)1, 2, 9 Strelkov S.V.... Herrmann H. (2004)
    42. The Val81 missense mutation of the melanocortin 3 receptor gene, but not the 1908c/T nucleotide polymorphism in lamin A/C gene, is associated with hyperleptinemia and hyperinsulinemia in obese Greek caucasians. (PubMed id 15636422)1, 4, 9 Yiannakouris N....Mantzoros C.S. (2004)
    43. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. (PubMed id 12714972)1, 2, 9 Eriksson M.... Collins F.S. (2003)
    44. Multisystem dystrophy syndrome due to novel missense mutations in the amino-terminal head and alpha-helical rod domains of the lamin A/C gene. (PubMed id 12015247)1, 2, 9 Garg A.... Bowcock A.M. (2002)
    45. Structure of the globular tail of nuclear lamin. (PubMed id 11901143)1, 2, 9 Dhe-Paganon S.... Shoelson S.E. (2002)
    46. Lamin A/C mutations with lipodystrophy, cardiac abnormalities, and muscular dystrophy. (PubMed id 12196663)1, 2, 9 van der Kooi A.J.... de Visser M. (2002)
    47. Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy. (PubMed id 11792809)1, 2, 9 Ostlund C....Worman H.J. (2001)
    48. Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. (PubMed id 10739751)1, 2, 9 Speckman R.A.... Bowcock A.M. (2000)
    49. Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan- type familial partial lipodystrophy. (PubMed id 10587585)1, 2, 9 Cao H. and Hegele R.A. (2000)
    50. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 10080180)1, 2, 9 Bonne G.... Schwartz K. (1999)
    51. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. (PubMed id 10580070)1, 2, 9 Fatkin D.... Seidman C.E. (1999)
    52. Autosomal recessive Emery-Dreifuss muscular dystrophy caused by a novel mutation (R225Q) in the lamin A/C gene identified by exome sequencing. (PubMed id 22431096)1, 2 Jimenez-Escrig A....Sanchez-Herranz A. (2012)
    53. Novel LMNA mutations in patients with Emery-Dreifuss muscular dystrophy and functional characterization of four LMNA mutations. (PubMed id 20848652)1, 2 Scharner J.... Zammit P.S. (2011)
    54. Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). (PubMed id 21498514)1, 2 Ahmady E....Burgon P.G. (2011)
    55. Clinical and mutational spectrum in a cohort of 105 u nrelated patients with dilated cardiomyopathy. (PubMed id 21846512)1, 2 Millat G....Rousson R. (2011)
    56. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    57. LMNA rs4641 and the muscle lamin A and C isoforms in twins--metabolic implications and transcriptional regulation. (PubMed id 20501691)1, 4 Wegner L....Vaag A. (2010)
    58. A novel custom resequencing array for dilated cardiom yopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (2010)
    59. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. (PubMed id 19933576)1, 2 Haque F.... Shackleton S. (2010)
    60. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    61. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    62. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    63. LMNA gene mutation search in Polish patients: new fea tures of the heterozygous Arg482Gln mutation phenotype. (PubMed id 19859838)1, 4 Klupa T....Malecki M.T. (2009)
    64. The role of Lamin A/C mutations in Danish patients wi th idiopathic dilated cardiomyopathy. (PubMed id 19875404)1, 4 MA...Christiansen M. (2009)
    65. A promoter polymorphism of lamin A/C gene is an indep endent genetic predisposition to arterial stiffness in a Japanese general popul ation (the Tanno and Sobetsu study). (PubMed id 19672032)1, 4 Akasaka H....Shimamoto K. (2009)
    66. Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. (PubMed id 18606848)1, 2 Zhang Y.Q. and Sarge K.D. (2008)
    67. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. (PubMed id 18848371)1, 4 Cluett C....Melzer D. (2008)
    68. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4 Schjeide B.M....Bertram L. (2008)
    69. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    70. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    71. Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. (PubMed id 16117820)1, 4 Liang H....Mabuchi H. (2005)
    72. A new mutation of the lamin A/C gene leading to autosomal dominant axonal neuropathy, muscular dystrophy, cardiac disease, and leuconychia. (PubMed id 14985400)1, 2 Goizet C.... Ferrer X. (2004)
    73. Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy. (PubMed id 15317753)1, 2 Navarro C.L.... Levy N. (2004)
    74. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    75. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    76. A new clinical condition linked to a novel mutation in lamins A and C with generalized lipoatrophy, insulin-resistant diabetes, disseminated leukomelanodermic papules, liver steatosis, and cardiomyopathy. (PubMed id 12629077)1, 2 Caux F....Christin-Maitre S. (2003)
    77. Lamin a truncation in Hutchinson-Gilford progeria. (PubMed id 12702809)1, 3 De Sandre-Giovannoli A....Levy N. (2003)
    78. Apical left ventricular aneurysm without atrio-ventricular block due to a lamin A/C gene mutation. (PubMed id 14675861)1, 2 Forissier J.-F....Komajda M. (2003)
    79. Identification of lamin A/C ( LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy 1B. (PubMed id 12032588)1, 2 Ki C.S....Kim J.W. (2002)
    80. Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. (PubMed id 12475961)1, 2 Markiewicz E.... Hutchison C.J. (2002)
    81. The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy. (PubMed id 12057196)1, 2 Krimm I.... Zinn-Justin S. (2002)
    82. Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C. (PubMed id 12075506)1, 2 Novelli G.... Bonne G. (2002)
    83. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    84. Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PubMed id 10514485)1, 2 Barton R.M. and Worman H.J. (1999)
    85. In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease. (PubMed id 9030603)1, 2 Kilic F....Sinensky M. (1997)
    86. An alternative splicing product of the lamin A/C gene lacks exon 10. (PubMed id 8621584)1, 2 Machiels B.M.... Broers J.L. (1996)
    87. Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. (PubMed id 8838815)1, 3 Wydner K.L....Lawrence J.B. (1996)
    88. Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. (PubMed id 8511676)1, 3 Kamat A.K....Miller O.J. (1993)
    89. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. (PubMed id 3453101)1, 2 McKeon F.D.... Caput D. (1986)
    90. cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. (PubMed id 3462705)1, 2 Fisher D.Z.... Blobel G. (1986)
    91. Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma. (PubMed id 19144202)1, 9 Wu Z....Zhao F. (2009)
    92. Identification of mutational hot spots in LMNA encoding lamin A/C in patients with familial dilated cardiomyopathy. (PubMed id 18795223)1, 9 Perrot A....Ozcelik C. (2009)
    93. Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis. (PubMed id 18767923)1, 9 Rauner M....Hofbauer L.C. (2009)
    94. High yield of LMNA mutations in patients with dilated cardiomyopathy and/or conduction disease referred to cardiogenetics outpatient clinics. (PubMed id 18035086)1, 9 van Tintelen J.P....van den Berg M.P. (2007)
    95. Lack of mutations in LMNA, its promoter region, and the cellular retinoic acid binding protein II (CRABP II) in HIV associated lipodystrophy. (PubMed id 12844477)1, 9 Behrens G.M....Schmidt H.H. (2003)
    96. Lamin A/C deficiency as a cause of familial dilated cardiomyopathy. (PubMed id 19384091)1, 9 Malhotra R. and Mason P.K. (2009)
    97. A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. (PubMed id 16278265)2, 9 Van Esch H.... Garg A. (2006)
    98. Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. (PubMed id 12524233)1, 9 Hegele R.A....Cao H. (2003)
    99. Lamin A/C gene mutations in familial cardiomyopathy w ith advanced atrioventricular block and arrhythmia. (PubMed id 19638735)1, 9 Saga A....Shimokawa H. (2009)
    100. R25G mutation in exon 1 of LMNA gene is associated wi th dilated cardiomyopathy and limb-girdle muscular dystrophy 1B. (PubMed id 20092787)1, 9 Yuan W.L....Huang W.J. (2009)
    101. Clinical and molecular genetic spectrum of autosomal dominant Emery- Dreifuss muscular dystrophy due to mutations of the lamin A/C gene. (PubMed id 10939567)2, 9 Bonne G.... Muntoni F. (2000)
    102. Genetic and ultrastructural studies in dilated cardio myopathy patients: a large deletion in the lamin A/C gene is associated with ca rdiomyocyte nuclear envelope disruption. (PubMed id 20127487)1, 9 Gupta P....Tesson F. (2010)
    103. Atypical progeroid syndrome due to heterozygous misse nse LMNA mutations. (PubMed id 19875478)1, 9 Garg A....Crow Y. (2009)
    104. LMNA messenger RNA expression in highly active antiretroviral therapy-treated HIV-positive patients. (PubMed id 18077842)1, 9 Miranda M....Vendrell J. (2007)
    105. Multitissular involvement in a family with LMNA and EMD mutations: Role of digenic mechanism? (PubMed id 17536044)1, 9 Ben Yaou R....Bonne G. (2007)
    106. Lamin A/C assembly defects in Emery-Dreifuss muscular dystrophy can be regulated by culture medium composition. (PubMed id 16697197)1, 9 Holt I....Morris G.E. (2006)
    107. Lamin A/C and polymeric actin in genome organization. (PubMed id 18612243)1, 9 Ondrej V....Kozubek S. (2008)
    108. Association of homozygous LMNA mutation R471C with new phenotype: mandibuloacral dysplasia, progeria, and rigid spine muscular dystrophy. (PubMed id 18348272)1, 9 Zirn B....Hahn A. (2008)
    109. Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy. (PubMed id 18364375)1, 9 Vantyghem M.C....Wemeau J.L. (2008)
    110. A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy. (PubMed id 18031308)1, 9 Araujo-Vilar D....Costa-Freitas A.T. (2008)
    111. Lamin A/C mutations associated with familial and sporadic cases of dilated cardiomyopathy in Koreans. (PubMed id 17334235)1, 9 Song K....Kim J.J. (2007)
    112. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. (PubMed id 17612587)1, 9 Caron M....Vigouroux C. (2007)
    113. Dilated cardiomyopathy caused by LMNA mutations. Clinical and morphological studies. (PubMed id 16981056)1, 9 Bilinska Z.T....Ruzyl/l/o W. (2006)
    114. [Clinical, genealogical and molecular genetic study of Emery-Dreifuss muscular dystrophy] (PubMed id 17117676)1, 9 Rudenskaia G.E....Poliakov A.V. (2006)
    115. [A novel LMNA gene mutation E82K associated with familial dilated cardiomyopathy] (PubMed id 16266469)1, 9 Wang H....Hui R.T. (2005)
    116. Increased expression of the Hutchinson-Gilford proger ia syndrome truncated lamin A transcript during cell aging. (PubMed id 19172989)1, 9 Rodriguez S....Eriksson M. (2009)
    117. Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. (PubMed id 17870066)1, 9 Huang S....Oshima J. (2008)
    118. Lamin A/C is a risk biomarker in colorectal cancer. (PubMed id 18714339)1, 9 Willis N.D....Hutchison C.J. (2008)
    119. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. (PubMed id 17701980)1, 9 Maioli M.A....Marrosu M.G. (2007)
    120. Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes. (PubMed id 17469202)1, 9 Moulson C.L....Miner J.H. (2007)
    121. Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. (PubMed id 16239243)1, 9 Arocena D.G....Hagerman P.J. (2005)
    122. Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy. (PubMed id 12788894)1, 9 Simha V....Garg A. (2003)
    123. Dyslipemia in familial partial lipodystrophy caused by an R482W mutation in the LMNA gene. (PubMed id 11344241)1, 9 Schmidt H.H....Brabant G. (2001)
    124. LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration. (PubMed id 10999791)1, 9 Hegele R.A....Anderson C.M. (2000)
    125. Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins. (PubMed id 10984438)1, 9 Dechat T....Foisner R. (2000)
    126. Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated card iomyopathy. (PubMed id 20160190)1, 9 Cowan J....Hershberger R.E. (2010)
    127. Identification of a new lamin A/C mutation in a chine se family affected with atrioventricular block as the prominent phenotype. (PubMed id 20155465)1, 9 Wu X....Yang J. (2010)
    128. LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance. (PubMed id 20130076)1, 9 Boschmann M....Jordan J. (2010)
    129. LMNA, ZMPSTE24, and LBR are not mutated in scleroderm a. (PubMed id 19645629)1, 9 Gaudy-Marqueste C....De Sandre-Giovannoli A. (2009)
    130. Germinal mosaicism for LMNA mimics autosomal recessive congenital muscular dystrophy. (PubMed id 19084400)1, 9 Makri S....Guicheney P. (2009)
    131. Dynamic complexes of A-type lamins and emerin influence adipogenic capacity of the cell via nucleocytoplasmic distribution of beta-catenin. (PubMed id 19126678)1, 9 Tilgner K....Markiewicz E. (2009)
    132. The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation. (PubMed id 19201734)1, 9 Wojtanik K.M....Londos C. (2009)
    133. LMNA mRNA expression is altered in human obesity and type 2 diabetes. (PubMed id 18497734)1, 9 Miranda M....Vendrell J. (2008)
    134. Emerinopathy and laminopathy clinical, pathological and molecular features of muscular dystrophy with nuclear envelopathy in Japan. (PubMed id 18646565)1, 9 Astejada M.N....Hayashi Y.K. (2007)
    135. Malignant mutation in the lamin A/C gene causing progressive conduction system disease and early sudden death in a family with mild form of limb-girdle muscular dystrophy. (PubMed id 17605093)1, 9 Antoniades L....Katritsis D.G. (2007)
    136. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. (PubMed id 16481476)1, 9 Frock R.L....Kennedy B.K. (2006)
    137. [Diseases associated with lamin A/C gene defects: what the clinical cardiologist ought to know] (PubMed id 15080529)1, 9 Pasotti M....Arbustini E. (2004)
    138. Emerin interacts in vitro with the splicing-associated factor, YT521- B. (PubMed id 12755701)1, 9 Wilkinson F.L.... Morris G.E. (2003)
    139. Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene. (PubMed id 14510863)4, 9 Owen K.R....Hattersley A.T. (2003)
    140. A novel lamin A/C mutation in a family with dilated cardiomyopathy, prominent conduction system disease, and need for permanent pacemaker implantation. (PubMed id 12486434)2, 9 Hershberger R.E.... Litt M. (2002)
    141. Expression of nuclear lamins in human tissues and cancer cell lines and transcription from the promoters of the lamin A/C and B1 genes. (PubMed id 9367621)1, 9 Lin F. and Worman H.J. (1997)
    142. Mouse and human hemopoietic cell lines of erythroid lineage express lamins A,B and C. (PubMed id 1599464)1, 9 Martelli A.M....Cocco L. (1992)
    143. Connexin 43 remodeling induced by LMNA gene mutation Glu82Lys in familial dilated cardiomyopathy with atrial ventricular block. (PubMed id 20497714)1, 9 Sun L.P....Pu J.L. (2010)
    144. Muscle imaging analogies in a cohort of patients with different clinical phenotypes caused by LMNA gene mutations. (PubMed id 19882644)1, 9 Carboni N....Marrosu M.G. (2010)
    145. Expanding the phenotype of sudden cardiac death-An un usual presentation of a family with a Lamin A/C mutation. (PubMed id 18691775)1, 9 De Backer J....Duytschaever M. (2010)
    146. A novel LMNA mutation (R189W) in familial dilated car diomyopathy: evidence for a 'hot spot' region at exon 3: a case report. (PubMed id 20307303)1, 9 Botto N....Andreassi M.G. (2010)
    147. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. (PubMed id 19328042)1, 9 Pan H....Garg V. (2009)
    148. Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy. (PubMed id 18805829)1, 9 Araujo-Vilar D....Lado-Abeal J. (2009)
    149. Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS. (PubMed id 19727227)1, 9 Ju W.N....Zhong N. (2009)
    150. Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. (PubMed id 19124654)1, 9 MAcjat A....Misteli T. (2009)
    151. Heart transplantation in 7 patients from a single fam ily with limb-girdle muscular dystrophy caused by lamin A/C mutation. (PubMed id 19446900)1, 9 Ambrosi P....Habib G. (2009)
    152. Novel LMNA gene mutation in a patient with Atypical Werner's Syndrome. (PubMed id 19270485)1, 9 Doh Y.J....Lee I.K. (2009)
    153. Emery-Dreifuss dystrophy: a 4-year follow-up on a lam inopathy of special interest. (PubMed id 20054742)1, 9 Hausmanowa-Petrusewicz I....Opolski G. (2009)
    154. Absence of Lamin A/C gene mutations in four Wiedemann -Rautenstrauch syndrome patients. (PubMed id 19938095)1, 9 Morales L.C....Arboleda H. (2009)
    155. Obliteration of cardiomyocyte nuclear architecture in a patient with LMNA gene mutation. (PubMed id 18502446)1, 9 Fidzianska A....Hausmanowa-Petrusewicz I. (2008)
    156. Muscle MRI findings in patients with an apparently exclusive cardiac phenotype due to a novel LMNA gene mutation. (PubMed id 18337098)1, 9 Carboni N....Marrosu M.G. (2008)
    157. Incomplete nonsense-mediated decay of mutant lamin A/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia. (PubMed id 17987279)1, 9 Geiger S.K....Weichenhan D. (2008)
    158. Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation. (PubMed id 18339564)1, 9 Madej-Pilarczyk A....Hausmanowa-Petrusewicz I. (2008)
    159. Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin. (PubMed id 18442998)1, 9 Wang Y....Worman H.J. (2008)
    160. A novel LMNA gene mutation Leu162Pro and the associated clinical characteristics in a family with autosomal-dominant emery-dreifuss muscular dystrophy. (PubMed id 18816602)1, 9 Kim H.Y....Sung I.H. (2008)
    161. A novel mutation in a large French-Canadian family with LGMD1B. (PubMed id 18714801)1, 9 Chrestian N....Dupre N. (2008)
    162. Long-term outcome and risk stratification in dilated cardiolaminopathies. (PubMed id 18926329)1, 9 Pasotti M....Arbustini E. (2008)
    163. Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C. (PubMed id 18478590)1, 9 Rankin J....Ellard S. (2008)
    164. Expression of the myodystrophic R453W mutation of lamin A in C2C12 myoblasts causes promoter-specific and global epigenetic defects. (PubMed id 18396274)1, 9 Hakelien A.M....Collas P. (2008)
    165. Founder effect and estimation of the age of the c.892C>T (p.Arg298Cys) mutation in LMNA associated to Charcot-Marie-Tooth subtype CMT2B1 in families from North Western Africa. (PubMed id 18549403)1, 9 Hamadouche T....Delague V. (2008)
    166. The R527H mutation in LMNA gene causes an increased sensitivity to ionizing radiation. (PubMed id 18604166)1, 9 di Masi A....Novelli G. (2008)
    167. Mandibuloacral dysplasia and a novel LMNA mutation in a woman with severe progressive skeletal changes. (PubMed id 17935239)1, 9 Kosho T....Fukushima Y. (2007)
    168. [The role of lamins and mutations of LMNA gene in physiological and premature aging] (PubMed id 17718387)1, 9 Sliwinska M.A. (2007)
    169. New metabolic phenotypes in laminopathies: LMNA mutations in patients with severe metabolic syndrome. (PubMed id 17711925)1, 9 Decaudain A....Vigouroux C. (2007)
    170. The heterozygous LMNA mutation p.R471G causes a variable phenotype with features of two types of familial partial lipodystrophy. (PubMed id 18041775)1, 9 Muschke P....Wieacker P. (2007)
    171. Hutchinson-Gilford progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature. (PubMed id 17459035)1, 9 Mazereeuw-Hautier J....Harper J.I. (2007)
    172. Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. (PubMed id 17550303)1, 9 Lee T.H....Avraham S. (2007)
    173. Novel LMNA mutations seen in patients with familial partial lipodystrophy subtype 2 (FPLD2; MIM 151660). (PubMed id 17250669)2, 9 Lanktree M.... Hegele R.A. (2007)
    174. Prelamin A farnesylation and progeroid syndromes. (PubMed id 17090536)1, 9 Young S.G....Fong L.G. (2006)
    175. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. (PubMed id 17097067)1, 9 Muchir A....Worman H.J. (2006)
    176. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. (PubMed id 16461887)1, 9 McClintock D....Djabali K. (2006)
    177. Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy. (PubMed id 16825283)1, 9 Wang Y....Worman H.J. (2006)
    178. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. (PubMed id 16179429)1, 9 Constantinescu D....Csoka A.B. (2006)
    179. Deletion of the LMNA initiator codon leading to a neurogenic variant of autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 15639119)1, 9 Walter M.C....Lochmuller H. (2005)
    180. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle. (PubMed id 15671068)1, 9 Zhang Q.... Shanahan C.M. (2005)
    181. The lethal phenotype of a homozygous nonsense mutation in the lamin A/C gene. (PubMed id 15668447)1, 9 van Engelen B.G....Lammens M. (2005)
    182. Major myofibrillar changes in early onset myopathy due to de novo heterozygous missense mutation in lamin A/C gene. (PubMed id 16288872)1, 9 D'Amico A....Bertini E. (2005)
    183. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress. (PubMed id 15982412)1, 9 Paradisi M....Djabali K. (2005)
    184. Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. (PubMed id 16126733)1, 9 Glynn M.W. and Glover T.W. (2005)
    185. Lamins A and C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 16218190)1, 9 Motsch I....Ellis J.A. (2005)
    186. Type A insulin resistance syndrome revealing a novel lamin A mutation. (PubMed id 15919811)1, 9 Young J....Vigouroux C. (2005)
    187. Laminopathies and atherosclerosis. (PubMed id 15205220)1, 9 Al-Shali K.Z. and Hegele R.A. (2004)
    188. Paternal origin of LMNA mutations in Hutchinson-Gilford progeria. (PubMed id 15032975)1, 9 D'Apice M.R....Novelli G. (2004)
    189. Familial partial lipodystrophy associated with compound heterozygosity for novel mutations in the LMNA gene. (PubMed id 15298354)1, 9 Savage D.B....Schafer A.J. (2004)
    190. Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A/C. (PubMed id 14607793)4, 9 Tazir M....Grid D. (2004)
    191. A lamin A/C beta-strand containing the site of lipodystrophy mutations is a major surface epitope for a new panel of monoclonal antibodies. (PubMed id 15026149)1, 9 Manilal S....Morris G.E. (2004)
    192. The phenotypic manifestations of autosomal recessive axonal Charcot-Marie-Tooth due to a mutation in Lamin A/C gene. (PubMed id 12467734)1, 9 Chaouch M....Grid D. (2003)
    193. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. (PubMed id 12783988)1, 9 Holt I....Morris G.E. (2003)
    194. Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription. (PubMed id 14597414)1, 9 Capanni C....Lattanzi G. (2003)
    195. Mandibuloacral dysplasia caused by homozygosity for the R527H mutation in lamin A/C. (PubMed id 14627682)1, 9 Shen J.J....Potocki L. (2003)
    196. The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. (PubMed id 11709282)1, 9 Mounkes L.C....Stewart C.L. (2001)
    197. Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. (PubMed id 11792810)1, 9 Raharjo W.H....Burke B. (2001)
    198. Skeletal muscle pathology in autosomal dominant Emery-Dreifuss muscular dystrophy with lamin A/C mutations. (PubMed id 11532159)1, 9 Sewry C.A....Muntoni F. (2001)
    199. Novel lamin A/C mutations in two families with dilated cardiomyopathy and conduction system disease. (PubMed id 11561226)2, 9 Jakobs P.M.... Hershberger R.E. (2001)
    200. A missense mutation in the exon 8 of lamin A/C gene in a Japanese case of autosomal dominant limb-girdle muscular dystrophy and cardiac conduction block. (PubMed id 11525883)2, 9 Kitaguchi T.... Bonne G. (2001)
    201. [Major insulin resistance syndromes: clinical and physiopathological aspects] (PubMed id 11833462)1, 9 Vigouroux C....Capeau J. (2001)
    202. Phenotypic heterogeneity in patients with familial partial lipodystrophy (dunnigan variety) related to the site of missense mutations in lamin a/c gene. (PubMed id 11231979)1, 9 Garg A....Bowcock A.M. (2001)
    203. Structural alterations of Lamin A protein in dilated c ardiomyopathy. (PubMed id 23701190)1 Bhattacharjee P....Sengupta K. (2013)
    204. LMNA mutations in Polish patients with dilated cardiom yopathy: prevalence, clinical characteristics, and in vitro studies. (PubMed id 23702046)1 Saj M....Ploski R. (2013)
    205. The protein kinase Akt/PKB regulates both prelamin A d egradation and Lmna gene expression. (PubMed id 23430973)1 Bertacchini J....Marmiroli S. (2013)
    206. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    207. Dilated cardiomyopathy and skeletal myopathy: presenti ng features of a laminopathy. (PubMed id 23329710)1 Sims-Williams H.P....Walker P.R. (2013)
    208. Lamin A/C depletion enhances DNA damage-induced stalle d replication fork arrest. (PubMed id 23319047)1 Singh M....Pandita T.K. (2013)
    209. Soft substrates normalize nuclear morphology and preve nt nuclear rupture in fibroblasts from a laminopathy patient with compound heter ozygous LMNA mutations. (PubMed id 23324461)1 Tamiello C....Bouten C.C. (2013)
    210. Gender-specific differences in major cardiac events an d mortality in lamin A/C mutation carriers. (PubMed id 23183350)1 van Rijsingen I.A....Pinto Y.M. (2013)
    211. Nuclear lamin-A scales with tissue stiffness and enhan ces matrix-directed differentiation. (PubMed id 23990565)1 Swift J....Discher D.E. (2013)
    212. Lamin A tail modification by SUMO1 is disrupted by fam ilial partial lipodystrophy-causing mutations. (PubMed id 23243001)1 Simon D.N....Wilson K.L. (2013)
    213. Genetic and clinical characteristics of skeletal and c ardiac muscle in patients with lamin A/C gene mutations. (PubMed id 23450819)1 Carboni N....Marrosu M.G. (2013)
    214. Prelamin A accelerates vascular calcification via acti vation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells. (PubMed id 23564641)1 Liu Y....Shanahan C.M. (2013)
    215. CMR-verified interstitial myocardial fibrosis as a mar ker of subclinical cardiac involvement in LMNA mutation carriers. (PubMed id 23328570)1 Fontana M....Masci P.G. (2013)
    216. Elevated MTORC1 signaling and impaired autophagy. (PubMed id 23064282)1 Ramos F.J....Kennedy B.K. (2013)
    217. Homozygous lamin A/C familial lipodystrophy R482Q muta tion in autosomal recessive Emery Dreifuss muscular dystrophy. (PubMed id 23313286)1 Wiltshire K.M....Brownell A.K. (2013)
    218. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    219. Mutations in the Lamin A/C gene mimic arrhythmogenic r ight ventricular cardiomyopathy. (PubMed id 22199124)1 Quarta G....Elliott P.M. (2012)
    220. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (2012)
    221. Variants of the lamin A/C (LMNA) gene in non-valvular atrial fibrillation patients: a possible pathogenic role of the Thr528Met mutati on. (PubMed id 22413764)1 Saj M....Ploski R. (2012)
    222. Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway. (PubMed id 22301279)1 Kong L....Klocker H. (2012)
    223. A bioinformatics analysis of Lamin-A regulatory networ k: a perspective on epigenetic involvement in Hutchinson-Gilford progeria syndro me. (PubMed id 22533413)1 Arancio W. (2012)
    224. Sp1 transcription factor interaction with accumulated prelamin a impairs adipose lineage differentiation in human mesenchymal stem cel ls: essential role of sp1 in the integrity of lipid vesicles. (PubMed id 23197810)1 Ruiz de Eguino G....Rodriguez C.I. (2012)
    225. Human longevity and common variations in the LMNA gene : a meta-analysis. (PubMed id 22340368)1 Conneely K.N....Collins F.S. (2012)
    226. Indoxyl sulfate promotes vascular smooth muscle cell s enescence with upregulation of p53, p21, and prelamin A through oxidative stress . (PubMed id 22555846)1 Muteliefu G....Niwa T. (2012)
    227. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    228. Unique preservation of neural cells in Hutchinson- Gil ford progeria syndrome is due to the expression of the neural-specific miR-9 mic roRNA. (PubMed id 22840390)1 Nissan X....Peschanski M. (2012)
    229. Blood glutathione decrease in subjects carrying lamin A/C gene mutations is an early marker of cardiac involvement. (PubMed id 22071332)1 Meune C....Pecker F. (2012)
    230. S100A6 is transcriptionally regulated by b-catenin and interacts with a novel target, lamin A/C, in colorectal cancer cells. (PubMed id 22560296)1 Kilanczyk E....Filipek A. (2012)
    231. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    232. Protein profiling reveals energy metabolism and cytosk eletal protein alterations in LMNA mutation carriers. (PubMed id 22326558)1 Magagnotti C....Benedetti S. (2012)
    233. LMNA knock-down affects differentiation and progressio n of human neuroblastoma cells. (PubMed id 23049808)1 Maresca G....D'Agnano I. (2012)
    234. Structures of the lamin A/C R335W and E347K mutants: i mplications for dilated cardiolaminopathies. (PubMed id 22266370)1 Bollati M....Bolognesi M. (2012)
    235. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. (PubMed id 23048029)1 Choi J.C....Worman H.J. (2012)
    236. Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular minerali zation, and poor biomechanical properties. (PubMed id 22893709)1 Schmidt E....Eriksson M. (2012)
    237. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    238. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    239. Abnormal p38a mitogen-activated protein kinase signali ng in dilated cardiomyopathy caused by lamin A/C gene mutation. (PubMed id 22773734)1 Muchir A....Worman H.J. (2012)
    240. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    241. Methylation status of lamin A/C in gastric cancer cell lines. (PubMed id 22057372)1 Lee W.S....Rha S.Y. (2012)
    242. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    243. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    244. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)1 Fang Y....Shen X. (2012)
    245. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    246. Phenotypic diversity in patients with lipodystrophy as sociated with LMNA mutations. (PubMed id 22700598)1 Mory P.B....Moises R.S. (2012)
    247. A novel homozygous p.Arg527Leu LMNA mutation in two un related Egyptian families causes overlapping mandibuloacral dysplasia and proger ia syndrome. (PubMed id 22549407)1 Al-Haggar M....Puzianowska-Kuznicka M. (2012)
    248. LMNA variants cause cytoplasmic distribution of nuclea r pore proteins in Drosophila and human muscle. (PubMed id 22186027)1 Dialynas G....Wallrath L.L. (2012)
    249. Risk factors for malignant ventricular arrhythmias in lamin a/c mutation carriers a European cohort study. (PubMed id 22281253)1 van Rijsingen I.A....Pinto Y.M. (2012)
    250. Identification of novel mutations in LMNA associated w ith familial forms of dilated cardiomyopathy. (PubMed id 22224630)1 Stallmeyer B....Schulze-Bahr E. (2012)
    251. Cardiac involvement in patients with lamin A/C gene mu tations: a cohort observation. (PubMed id 22806367)1 Carboni N....Marrosu M.G. (2012)
    252. Perturbation of nuclear lamin A causes cell death in c hondrocytes. (PubMed id 22231515)1 Attur M....Abramson S.B. (2012)
    253. Quantitative expression of the mutated lamin A/C gene in patients with cardiolaminopathy. (PubMed id 23062543)1 Narula N....Arbustini E. (2012)
    254. C1824T mutation in the LMNA gene has no association wi th senile cataract. (PubMed id 22079058)1 Sadikov T....Goldenberg-Cohen N. (2012)
    255. Inflammatory changes in infantile-onset LMNA-associat ed myopathy. (PubMed id 21632249)1 Komaki H....Nishino I. (2011)
    256. Structural protein 4.1R is integrally involved in nuc lear envelope protein localization, centrosome-nucleus association and transcri ptional signaling. (PubMed id 21486941)1 Meyer A.J....Krauss S.W. (2011)
    257. Recapitulation of premature ageing with iPSCs from Hut chinson-Gilford progeria syndrome. (PubMed id 21346760)1 Liu G.H....Izpisua Belmonte J.C. (2011)
    258. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    259. Sudden cardiac death in a patient with lamin A/C muta tion in the absence of dilated cardiomyopathy or conduction disease. (PubMed id 21327842)1 Ehlermann P....Schimpf R. (2011)
    260. Targeted gene correction of laminopathy-associated LMN A mutations in patient-specific iPSCs. (PubMed id 21596650)1 Liu G.H....Izpisua Belmonte J.C. (2011)
    261. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    262. Assessment of LMNA copy number variation in 58 proban ds with dilated cardiomyopathy. (PubMed id 22029807)1 Norton N....Hershberger R.E. (2011)
    263. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    264. Gene expression, chromosome position and lamin A/C mut ations. (PubMed id 21818408)1 Puckelwartz M.J....McNally E.M. (2011)
    265. Subcellular localization of SREBP1 depends on its inte raction with the C-terminal region of wild-type and disease related A-type lamin s. (PubMed id 21993218)1 Duband-Goulet I....Buendia B. (2011)
    266. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    267. Polymorphisms in LMNA and near a SERPINA13 gene are n ot associated with cognitive performance in Chinese elderly males without demen tia. (PubMed id 21903150)1 Yeh H.L....Tsai S.J. (2011)
    268. Aberrant splicing in the LMNA gene caused by a novel mutation on the polypyrimidine tract of intron 5. (PubMed id 21462202)1 Carboni N....Marrosu M.G. (2011)
    269. LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue. (PubMed id 21945321)1 Bereziat V....Vigouroux C. (2011)
    270. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    271. Late gadolinium enhanced cardiovascular magnetic reso nance of lamin A/C gene mutation related dilated cardiomyopathy. (PubMed id 21689390)1 HolmstrAPm M....Lauerma K. (2011)
    272. A complex double deletion in LMNA underlies progressi ve cardiac conduction disease, atrial arrhythmias, and sudden death. (PubMed id 21406687)1 Marsman R.F....Bezzina C.R. (2011)
    273. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    274. Retinoblastoma-independent regulation of cell prolife ration and senescence by the p53-p21 axis in lamin Aa88/C-depleted cells. (PubMed id 21535365)1 Moiseeva O....Ferbeyre G. (2011)
    275. Reorganization of the nuclear lamina and cytoskeleton in adipogenesis. (PubMed id 21350821)1 Verstraeten V.L....Broers J.L. (2011)
    276. Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonates. (PubMed id 21915271)1 BAPkenkamp R....Gittenberger-de Groot A.C. (2011)
    277. A novel proteomics approach to identify SUMOylated pro teins and their modification sites in human cells. (PubMed id 21098080)1 Galisson F....Thibault P. (2011)
    278. Amphibian oocyte nuclei expressing lamin A with the pr ogeria mutation E145K exhibit an increased elastic modulus. (PubMed id 21941106)1 Kaufmann A....Stick R. (2011)
    279. Laminopathies and lamin-associated signaling pathways . (PubMed id 21400569)1 Maraldi N.M....Lattanzi G. (2011)
    280. Loss of A-type lamin expression compromises nuclear en velope integrity in breast cancer. (PubMed id 21627864)1 Capo-chichi C.D....Xu X.X. (2011)
    281. Genotype of the LMNA 1908C>T variant is associated with generalized obesity in Asian Indians in North India. (PubMed id 21599722)1 Sharma M....Luthra K. (2011)
    282. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    283. [Laminopathies: one gene, several diseases]. (PubMed id 21982404)1 Bertrand A.T....Bonne G. (2011)
    284. N-terminal Pro brain natriuretic peptide is a reliable biomarker of reduced myocardial contractility in patients with lamin A/C gene m utations. (PubMed id 20627339)1 Meune C....Bonne G. (2011)
    285. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    286. Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer. (PubMed id 21439080)1 Capo-chichi C.D....Xu X.X. (2011)
    287. Low and high expressing alleles of the LMNA gene: imp lications for laminopathy disease development. (PubMed id 21980471)1 RodrA-guez S. and Eriksson M. (2011)
    288. Loss of lamin A/C expression in stage II and III colo n cancer is associated with disease recurrence. (PubMed id 21621406)1 Belt E.J....Meijer G.A. (2011)
    289. Progerin and telomere dysfunction collaborate to trig ger cellular senescence in normal human fibroblasts. (PubMed id 21670498)1 Cao K....Collins F.S. (2011)
    290. The nucleoporin Nup88 is interacting with nuclear lam in A. (PubMed id 21289091)1 Lussi Y.C....Fahrenkrog B. (2011)
    291. High prevalence of laminopathies among patients with metabolic syndrome. (PubMed id 21724554)1 Dutour A....Morange P.E. (2011)
    292. A homozygous mutation of prelamin-A preventing its fa rnesylation and maturation leads to a severe lipodystrophic phenotype: new insi ghts into the pathogenicity of nonfarnesylated prelamin-A. (PubMed id 21346069)1 Le Dour C....Vigouroux C. (2011)
    293. Prelamin A-mediated recruitment of SUN1 to the nuclea r envelope directs nuclear positioning in human muscle. (PubMed id 21311568)1 Mattioli E....Lattanzi G. (2011)
    294. Myotonic dystrophy protein kinase is critical for nuclear envelope integrity. (PubMed id 21949239)2 Harmon E.B....Perryman M.B. (2011)
    295. The defective nuclear lamina in Hutchinson-gilford pr ogeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclea r localization of Ubc9. (PubMed id 21670151)1 Kelley J.B....Paschal B.M. (2011)
    296. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    297. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. (PubMed id 20974128)1 Candelario J....Comai L. (2011)
    298. A new c.1621 C > G, p.R541G lamin A/C mutation in a family with DCM and regional wall motion abnormalities (akinesis/dyskinesis): genotype-phenotype correlation. (PubMed id 21085127)1 MaA8ek L.A....BiliA8ska Z.T. (2011)
    299. Subcellular localization of SUN2 is regulated by lami n A and Rab5. (PubMed id 21655223)1 Liang Y....Chan S.Y. (2011)
    300. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    301. A conserved splicing mechanism of the LMNA gene contro ls premature aging. (PubMed id 21875900)1 Lopez-Mejia I.C....Tazi J. (2011)
    302. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    303. Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A. (PubMed id 22065502)1 Hisama F.M....Oshima J. (2011)
    304. Two children with 'dropped head' syndrome d ue to lamin A/C mutations. (PubMed id 20886652)1 Chemla J.C....Smith E.C. (2010)
    305. Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. (PubMed id 20819672)1 Cai M.Y....Weng J.P. (2010)
    306. Quantitative nanoproteomics for protein complexes (QNa noPX) related to estrogen transcriptional action. (PubMed id 19805454)1 Cheng P.C....Chen S.H. (2010)
    307. Overlapping syndrome with familial partial lipodystro phy, Dunnigan variety and cardiomyopathy due to amino-terminal heterozygous mis sense lamin A/C mutations. (PubMed id 20041886)1 Subramanyam L....Garg A. (2010)
    308. Lamin A precursor induces barrier-to-autointegration factor nuclear localization. (PubMed id 20581439)1 Capanni C....Lattanzi G. (2010)
    309. Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. (PubMed id 20605919)1 Benson E.K....Aaronson S.A. (2010)
    310. Simian virus 40 T/t antigens and lamin A/C small inte rfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4 ) mutant. (PubMed id 20147387)1 Meng Q....Kenney S.C. (2010)
    311. Proteomic dissection of cell type-specific H2AX-inter acting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (2010)
    312. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    313. Effect of progerin on the accumulation of oxidized pr oteins in fibroblasts from Hutchinson Gilford progeria patients. (PubMed id 19958786)1 Viteri G....Stadtman E.R. (2010)
    314. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (2010)
    315. Characterization of the head-to-tail overlap complexe s formed by human lamin A, B1 and B2 'half-minilamin' dimers. (PubMed id 20004208)1 Kapinos L.E....Herrmann H. (2010)
    316. Evolution of the phenotype in a family with an LMNA g ene mutation presenting with isolated cardiac involvement. (PubMed id 19768759)1 Carboni N....Marrosu M.G. (2010)
    317. LMNA E82K mutation activates FAS and mitochondrial pa thways of apoptosis in heart tissue specific transgenic mice. (PubMed id 21151901)1 Lu D....Zhang L. (2010)
    318. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440)1 Pozuelo-Rubio M. (2010)
    319. [Nucleopathies in children]. (PubMed id 21462476)1 Madej-Pilarczyk A. (2010)
    320. Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin. (PubMed id 20884875)1 LefA"vre C....Caron-Debarle M. (2010)
    321. Adipose tissue lamin A/C messenger RNA expression in women. (PubMed id 20045150)1 Nadeau M....Tchernof A. (2010)
    322. Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10. (PubMed id 20498703)1 Chaturvedi P. and Parnaik V.K. (2010)
    323. Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (2010)
    324. Identification of a lamin A/C gene mutation in a Taiw anese family with limb girdle muscular dystrophy and cardiomyopathy. (PubMed id 20615561)1 Chang S.H....Lei M.H. (2010)
    325. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    326. Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. (PubMed id 21179469)1 Mewborn S.K....McNally E. (2010)
    327. [Mutation analysis of LITAF, RAB7, LMNA and MTMR2 gene s in Chinese Charcot-Marie-Tooth disease.]. (PubMed id 20709679)1 Zhang R.X....Tang B.S. (2010)
    328. Familial partial lipodystrophy associated with the he terozygous LMNA mutation 1445G>A (Arg482Gln) in a Polish family. (PubMed id 20625965)1 Drac H....Hausmanowa-Petrusewicz I. (2010)
    329. Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and -independent signaling. (PubMed id 19725029)1 Zhu B....Kyprianou N. (2010)
    330. Kinetic analysis of RNA interference for lamin A/C in HeLa cells. (PubMed id 20732854)1 You S.J....Lee J.S. (2010)
    331. Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. (PubMed id 21327074)1 Simon D.N....Wilson K.L. (2010)
    332. Dynamics of lamin-A processing following precursor ac cumulation. (PubMed id 20526372)1 Liu Q....Roux K.J. (2010)
    333. Intermediate phenotypes identify divergent pathways t o Alzheimer's disease. (PubMed id 20574532)4 Shulman J.M....De Jager P.L. (2010)
    334. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    335. Comparison of phenotypes in male and female individua ls of a new family with Dunnigan type of familial partial lipodystrophy due to a lamin A/C R482W mutation. (PubMed id 19204888)1 Laudes M....Krone W. (2009)
    336. The D4Z4 macrosatellite repeat acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. (PubMed id 19247430)1 Ottaviani A....Magdinier F. (2009)
    337. Identification of a perinuclear positioning element i n human subtelomeres that requires A-type lamins and CTCF. (PubMed id 19644448)1 Ottaviani A....Magdinier F. (2009)
    338. A comparative study of Drosophila and human A-type la mins. (PubMed id 19855837)1 Schulze S.R....Wallrath L.L. (2009)
    339. Barrier-to-autointegration factor proteome reveals ch romatin-regulatory partners. (PubMed id 19759913)1 Montes de Oca R....Wilson K.L. (2009)
    340. Proteomic analysis of integrin-associated complexes i dentifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (2009)
    341. A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. (PubMed id 19926845)1 Taimen P....Goldman R.D. (2009)
    342. Ageing-related chromatin defects through loss of the NURD complex. (PubMed id 19734887)1 Pegoraro G....Misteli T. (2009)
    343. Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle. (PubMed id 18643848)1 Yamamoto S....Hirai Y. (2009)
    344. Different prelamin A forms accumulate in human fibrob lasts: a study in experimental models and progeria. (PubMed id 19351612)1 Dominici S....Lattanzi G. (2009)
    345. Association studies of 22 candidate SNPs with late-ons et Alzheimer's disease. (PubMed id 18780302)4 Figgins J.A....Kamboh M.I. (2009)
    346. Structure of the lamin A/C R482W mutant responsible f or dominant familial partial lipodystrophy (FPLD). (PubMed id 19574635)1 Magracheva E....Zdanov A. (2009)
    347. The R439C mutation in LMNA causes lamin oligomerizati on and susceptibility to oxidative stress. (PubMed id 19220582)1 Verstraeten V.L....Broers J.L. (2009)
    348. Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants. (PubMed id 19442658)1 Busch A....HA1bner S. (2009)
    349. Impaired nuclear functions lead to increased senescen ce and inefficient differentiation in human myoblasts with a dominant p.R545C m utation in the LMNA gene. (PubMed id 19589617)1 Kandert S....Dabauvalle M.C. (2009)
    350. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    351. Defects in cell spreading and ERK1/2 activation in fi broblasts with lamin A/C mutations. (PubMed id 19524666)1 Emerson L.J....Ellis J.A. (2009)
    352. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    353. Reduced expression of A-type lamins and emerin activates extracellular signal-regulated kinase in cultured cells. (PubMed id 19022376)1 Muchir A....Worman H.J. (2009)
    354. Reduced expression of lamin A/C results in modified c ell signaling and metabolism coupled with changes in expression of structural p roteins. (PubMed id 19775189)1 Chen S....Jackson D.A. (2009)
    355. Proteomics analysis of nucleolar SUMO-1 target protei ns upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (2009)
    356. Phosphorylation-dependent binding of human transcript ion factor MOK2 to lamin A/C. (PubMed id 19490114)1 Harper M....Ernoult-Lange M. (2009)
    357. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    358. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    359. Mislocalization of human transcription factor MOK2 in the presence of pathogenic mutations of lamin A/C. (PubMed id 17760566)1 Dreuillet C....Ernoult-Lange M. (2008)
    360. [The atypical of Werner syndrome: effect of laminopathy] (PubMed id 18959190)1 Smirnova N.V....Mikhel'son V.M. (2008)
    361. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    362. Effects of prelamin A processing inhibitors on the differentiation and activity of human osteoclasts. (PubMed id 18442054)1 Zini N....Lattanzi G. (2008)
    363. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    364. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. (PubMed id 18843043)1 Kudlow B.A....Kennedy B.K. (2008)
    365. Drugs affecting prelamin A processing: effects on heterochromatin organization. (PubMed id 18093584)1 Mattioli E....Lattanzi G. (2008)
    366. Tethering by lamin A stabilizes and targets the ING1 tumour suppressor. (PubMed id 18836436)1 Han X....Riabowol K. (2008)
    367. The binding of Tritrichomonas foetus to immobilized laminin-1 and its role in the cytotoxicity exerted by the parasite. (PubMed id 18667561)1 Petropolis D.B....Costa e Silva-Filho F. (2008)
    368. Plasma-membrane-anchored growth factor pro-amphiregulin binds A-type lamin and regulates global transcription. (PubMed id 18946024)1 Isokane M....Higashiyama S. (2008)
    369. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    370. Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. (PubMed id 18809582)1 Maggi L.B. Jr.... Weber J.D. (2008)
    371. Effects of lamin A/C, lamin B1, and viral US3 kinase activity on viral infectivity, virion egress, and the targeting of herpes simplex virus U(L)34-encoded protein to the inner nuclear membrane. (PubMed id 18524819)1 Mou F....Baines J.D. (2008)
    372. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
    373. Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes. (PubMed id 18982914)1 Ding S.L. and Shen C.Y. (2008)
    374. [A-type lamins and progeroA^d syndromes : persistent farnesylation with dramatic effects] (PubMed id 18950579)1 Navarro C.L....LAcvy N. (2008)
    375. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    376. Laminopathies in Russian families. (PubMed id 18564364)1 Rudenskaya G.E....Ginter E.K. (2008)
    377. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. (PubMed id 19015316)1 Gonzalez J.M....Andres V. (2008)
    378. Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartment. (PubMed id 18923140)1 Barrowman J....Michaelis S. (2008)
    379. Specific contribution of lamin A and lamin C in the development of laminopathies. (PubMed id 18538321)1 Sylvius N....Tesson F. (2008)
    380. Role for A-type lamins in herpesviral DNA targeting a nd heterochromatin modulation. (PubMed id 18497856)1 Silva L....Knipe D.M. (2008)
    381. Muscle dystrophy single point mutation in the 2B segment of lamin A does not affect the mechanical properties at the dimer level. (PubMed id 18308323)1 Zhang H....Buehler M.J. (2008)
    382. Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. (PubMed id 17848622)1 Liu Y....Zou Y. (2008)
    383. The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription. (PubMed id 19141474)1 Shimi T....Goldman R.D. (2008)
    384. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. (PubMed id 18311132)1 Scaffidi P. and Misteli T. (2008)
    385. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. (PubMed id 17573780)1 Hayakawa T....Nakayama J. (2007)
    386. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. (PubMed id 17683050)1 Cid C....Alcazar A. (2007)
    387. The mutant form of lamin A that causes Hutchinson-Gilf ord progeria is a biomarker of cellular aging in human skin. (PubMed id 18060063)1 McClintock D....Djabali K. (2007)
    388. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. (PubMed id 17301031)1 Halaschek-Wiener J. and Brooks-Wilson A. (2007)
    389. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. (PubMed id 17360355)1 Cao K....Collins F.S. (2007)
    390. Obstructive sleep apnea in 2 women with familial partial lipodystrophy due to a heterozygous LMNA R482Q mutation. (PubMed id 17893350)1 Hegele R.A....Rutt B.K. (2007)
    391. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)1 Koch H.B....Hermeking H. (2007)
    392. Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. (PubMed id 17227891)1 Pekovic V....Markiewicz E. (2007)
    393. Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells. (PubMed id 17291448)1 Pan Y....Agarwal A.K. (2007)
    394. Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. (PubMed id 17881656)1 Kandert S....Karakesisoglou I. (2007)
    395. An emerin 'proteome': purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. (PubMed id 17620012)1 Holaska J.M. and Wilson K.L. (2007)
    396. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PubMed id 17342744)1 Dall'Era M.A....Liu A.Y. (2007)
    397. Abl-SH3 binding protein 2, 3BP2, interacts with CIN85 and HIP-55. (PubMed id 17306257)1 Le Bras S....Deckert M. (2007)
    398. Oxidative stress implication in a new phenotype of amyotrophic quadricipital syndrome with cardiac involvement due to lamin A/C mutation. (PubMed id 17454124)1 Charniot J.C....Artigou J.Y. (2007)
    399. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)2 Yu L.-R.... Veenstra T.D. (2007)
    400. US3 of herpes simplex virus type 1 encodes a promiscuous protein kinase that phosphorylates and alters localization of lamin A/C in infected cells. (PubMed id 17428859)1 Mou F....Baines J.D. (2007)
    401. Accumulation of multiple forms of lamin A with down-regulation of FACE-1 suppresses growth in senescent human cells. (PubMed id 17352743)1 Ukekawa R....Ayusawa D. (2007)
    402. Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging. (PubMed id 17360326)1 Dechat T....Goldman R.D. (2007)
    403. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. (PubMed id 16738054)1 Shumaker D.K....Goldman R.D. (2006)
    404. Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo. (PubMed id 16371512)1 Bengtsson L. and Wilson K.L. (2006)
    405. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    406. Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. (PubMed id 16410549)1 Zastrow M.S.... Wilson K.L. (2006)
    407. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1 Kim S.C.... Zhao Y. (2006)
    408. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    409. Molecular mechanism of rigid spine with muscular dystrophy type 1 caused by novel mutations of selenoprotein N gene. (PubMed id 16779558)1 Okamoto Y....Arimura K. (2006)
    410. A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C. (PubMed id 16452503)1 Ivorra C....AndrAcs V. (2006)
    411. Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. (PubMed id 17069459)1 Radke J.R....White M.W. (2006)
    412. Dysfunction of lamin A triggers a DNA damage response and cellular senescence. (PubMed id 16344005)1 Lees-Miller S.P. (2006)
    413. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. (PubMed id 16518869)1 Lee S.C....Pervaiz S. (2006)
    414. Expression of disease-causing lamin A mutants impairs the formation of DNA repair foci. (PubMed id 16772334)1 Manju K....Parnaik V.K. (2006)
    415. Lamin A-dependent nuclear defects in human aging. (PubMed id 16645051)1 Scaffidi P. and Misteli T. (2006)
    416. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1 Nousiainen M.... Koerner R. (2006)
    417. Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates. (PubMed id 16289535)1 Hubner S....Jans D.A. (2006)
    418. Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis. (PubMed id 16823856)1 Greenberg S.A....Amato A.A. (2006)
    419. Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. (PubMed id 16212417)1 Catimel B....Nice E. (2005)
    420. Lamin A N-terminal phosphorylation is associated with myoblast activation: impairment in Emery-Dreifuss muscular dystrophy. (PubMed id 15744034)2 Cenni V.... Lattanzi G. (2005)
    421. Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations. (PubMed id 16246140)1 Meaburn K.J....Bridger J.M. (2005)
    422. Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)1 Kim J.-E.... White F.M. (2005)
    423. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PubMed id 16159877)1 McCracken S....Blencowe B.J. (2005)
    424. Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. (PubMed id 16248985)1 Zhong N....Brown W.T. (2005)
    425. Somatic and gonadal mosaicism in Hutchinson-Gilford progeria. (PubMed id 15793835)1 Wuyts W....Storm K. (2005)
    426. Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization. (PubMed id 15748902)1 Broers J.L....Ramaekers F.C. (2005)
    427. Etiological investigations in apparent type 2 diabetes: when to search for lamin A/C mutations? (PubMed id 16357800)1 Donadille B....Vigouroux C. (2005)
    428. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    429. Gene symbol: LMNA. Disease: cardiomyopathy, dilated, with conduction defect 1. (PubMed id 16156025)2 Arbustini Eloisa A.E.... Tavazzi L. (2005)
    430. Nucleolar proteome dynamics. (PubMed id 15635413)1 Andersen J.S....Mann M. (2005)
    431. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. (PubMed id 16129833)1 Capell B.C....Collins F.S. (2005)
    432. [Lamine gene mutations in dilated cardiomyopathy] (PubMed id 15798706)1 Zakliaz'minskaia E.V....Poliakov A.V. (2005)
    433. Two patients with 'Dropped head syndrome' due to mutations in LMNA or SEPN1 genes. (PubMed id 15961312)1 D'Amico A....Topaloglu H. (2005)
    434. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940)1 Zhao C.... Krug R.M. (2005)
    435. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)1 Guo D.... Wang C.-Y. (2005)
    436. Peripheral nerve lesions associated with a dominant missense mutation, E33D, of the lamin A/C gene. (PubMed id 16084085)1 Vital A....Vital C. (2005)
    437. A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy. (PubMed id 15140538)2 Kaerkkaeinen S.... Peuhkurinen K. (2004)
    438. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. (PubMed id 15184648)1 Goldman R.D....Collins F.S. (2004)
    439. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
    440. The stability of the nuclear lamina polymer changes with the composition of lamin subtypes according to their individual binding strengths. (PubMed id 15284226)1 Schirmer E.C. and Gerace L. (2004)
    441. Comprehensive proteomic analysis of interphase and mi totic 14-3-3-binding proteins. (PubMed id 15161933)1 Meek S.E....Piwnica-Worms H. (2004)
    442. Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin. (PubMed id 15355978)1 Choi J....Joo C.K. (2004)
    443. Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity. (PubMed id 15527767)1 Grimsby S....Souchelnytskyi S. (2004)
    444. CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. (PubMed id 14759373)1 Yusufzai T.M....Felsenfeld G. (2004)
    445. Lco1 is a novel widely expressed lamin-binding protein in the nuclear interior. (PubMed id 15265697)1 Vlcek S....Wilson K.L. (2004)
    446. Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations. (PubMed id 15372542)1 Muchir A....Bonne G. (2004)
    447. Homozygous missense mutation in the lamin A/C gene causes autosomal recessive Hutchinson-Gilford progeria syndrome. (PubMed id 15286156)2 Plasilova M.... Heinimann K. (2004)
    448. Lamin A expression levels are unperturbed at the normal and mutant alleles but display partial splice site selection in Hutchinson-Gilford progeria syndrome. (PubMed id 15342704)1 Reddel C.J. and Weiss A.S. (2004)
    449. Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes. (PubMed id 15060110)2 Csoka A.B....Hegele R.A. (2004)
    450. The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. (PubMed id 12718522)1 Stierle V....Duband-Goulet I. (2003)
    451. Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in HeLa cells. (PubMed id 12729796)1 Bechert K....Osborn M. (2003)
    452. Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. (PubMed id 12534602)1 Tilli C.M....Neumann H.A. (2003)
    453. Mutation analysis of the lamin A/C gene (LMNA) among patients with different cardiomuscular phenotypes. (PubMed id 14684700)2 Vytopil M.... Toniolo D. (2003)
    454. The strange case of the 'lumper' lamin A/C gene and human premature ageing. (PubMed id 13129702)1 Novelli G. and D'Apice M.R. (2003)
    455. Clinical relevance of atrial fibrillation/flutter, stroke, pacemaker implant, and heart failure in Emery-Dreifuss muscular dystrophy: a long-term longitudinal study. (PubMed id 12649505)2 Boriani G....Branzi A. (2003)
    456. Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts. (PubMed id 12670476)1 Lattanzi G....Maraldi N.M. (2003)
    457. Nuclear envelope alterations in fibroblasts from LGMD1B patients carrying nonsense Y259X heterozygous or homozygous mutation in lamin A/C gene. (PubMed id 14644157)1 Muchir A....Bonne G. (2003)
    458. Molecular characterization of protein kinase C-alpha binding to lamin A. (PubMed id 12112001)1 Martelli A.M....Cocco L. (2002)
    459. Directed proteomic analysis of the human nucleolus. (PubMed id 11790298)1 Andersen J.S.... Lamond A.I. (2002)
    460. Life at the edge: the nuclear envelope and human disease. (PubMed id 12154369)1 Burke B. and Stewart C.L. (2002)
    461. Lamin expression in human adipose cells in relation to anatomical site and differentiation state. (PubMed id 11836312)1 Lelliott C.J....Vidal-Puig A. (2002)
    462. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. (PubMed id 11929849)1 Lloyd D.J....Shackleton S. (2002)
    463. Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C. (PubMed id 11801724)1 Mislow J.M.K.... McNally E.M. (2002)
    464. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    465. Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. (PubMed id 12163176)1 Mislow J.M.... McNally E.M. (2002)
    466. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1 Scherl A.... Diaz J.-J. (2002)
    467. Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. (PubMed id 11953316)1 Ruchaud S....Earnshaw W.C. (2002)
    468. 1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C. (PubMed id 12018485)1 Krimm I....Zinn-Justin S. (2002)
    469. Absence of mutations in exon 8 of the gene in combination antiretroviral therapy-associated partial lipodystrophy. (PubMed id 12138353)1 Domingo P....Vazquez G. (2002)
    470. In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C. (PubMed id 12409453)1 Dreuillet C....Ernoult-Lange M. (2002)
    471. Emery-Dreifuss muscular dystrophy. (PubMed id 11973618)1 Helbling-Leclerc A....Schwartz K. (2002)
    472. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. (PubMed id 11691994)1 de Noronha C.M....Greene W.C. (2001)
    473. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. (PubMed id 11331782)1 Zhang D....Lieberman J. (2001)
    474. The nuclear envelope in muscular dystrophy and cardiovascular diseases. (PubMed id 11576443)1 Burke B....Stewart C.L. (2001)
    475. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q/W mutations in the lamin A/C gene. (PubMed id 11792811)1 Vigouroux C....Buendia B. (2001)
    476. A case of congenital generalized lipodystrophy: metabolic effects of four dietary regimens. Lack of association of CGL with polymorphism in the lamin A/C Gene. (PubMed id 11298098)4 Kazlauskaite R....Wajchenberg B.L. (2001)
    477. Interaction between emerin and nuclear lamins. (PubMed id 11173535)1 Sakaki M....Ishiura S. (2001)
    478. Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. (PubMed id 11792821)1 Lee K.K....Wilson K.L. (2001)
    479. Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement. (PubMed id 10662742)1 Brodsky G.L....Mestroni L. (2000)
    480. The inner nuclear membrane. (PubMed id 10960149)1 Worman H.J. and Courvalin J.C. (2000)
    481. Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening. (PubMed id 10727209)1 Tang K....Honn K.V. (2000)
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    483. Review: nuclear lamins--structural proteins with fundamental functions. (PubMed id 10806082)1 Gruenbaum Y....Cohen M. (2000)
    484. Direct interaction between emerin and lamin A. (PubMed id 10673356)1 Clements L....Morris G.E. (2000)
    485. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. (PubMed id 10381623)1 Ohi N.... Nakajima T. (1999)
    486. HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. (PubMed id 9436978)1 Vodicka M.A....Emerman M. (1998)
    487. In vitro interaction of the carboxy-terminal domain of lamin A with actin. (PubMed id 9563518)1 Sasseville A.M. and Langelier Y. (1998)
    488. Nuclear lamin expression in normal testis and testicular germ cell tumours of adolescents and adults. (PubMed id 9274531)1 Machiels B.M....Looijenga L.H. (1997)
    489. Genetic localization of a newly recognized autosomal dominant limb-girdle muscular dystrophy with cardiac involvement (LGMD1B) to chromosome 1q11-21. (PubMed id 9106535)1 van der Kooi A.J....Bolhuis P.A. (1997)
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    494. A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1. (PubMed id 7951328)1 Kass S....Fishman M.C. (1994)
    495. Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction. (PubMed id 8058329)1 Ozaki T....Sakiyama S. (1994)
    496. The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. (PubMed id 8278403)1 Mancini M.A....Lee W.H. (1994)
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    499. Emery-Dreifuss Muscular Dystrophy (PubMed id 20301609)1 Bonne G....Ben Yaou R. (1993)
    500. Functional analysis of phosphorylation sites in human lamin A controlling lamin disassembly, nuclear transport and assembly. (PubMed id 7925482)1 Haas M. and Jost E. (1993)
    501. Identification of novel phosphorylation sites in murine A-type lamins. (PubMed id 8477740)1 Eggert M....Jost E. (1993)
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    503. Hutchinson-Gilford Progeria Syndr ome (PubMed id 20301300)1 Gordon L.B....Collins F.S. (1993)
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    506. Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. (PubMed id 8324822)1 Foisner R. and Gerace L. (1993)
    507. Charcot-Marie-Tooth Neuropathy Typ e 2 (PubMed id 20301462)1 Bird T.D. (1993)
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    509. Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. (PubMed id 1602151)1 Dawson S.J. and White L.A. (1992)
    510. Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. (PubMed id 1667585)1 Clawson G.A....Kumar A. (1991)
    511. Functional characterization of Tat protein from human immunodeficiency virus. Evidence that Tat links viral RNAs to nuclear matrix. (PubMed id 2406262)1 Muller W.E....Schroder H.C. (1990)
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    513. Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. (PubMed id 2344612)1 Heald R. and McKeon F. (1990)
    514. Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells. (PubMed id 2544227)1 Muller W.E....Schroder H.C. (1989)
    515. Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation. (PubMed id 3403563)1 Worman H.J....Georgatos S.D. (1988)
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    517. Hypertonic-induced lamin A/C synthesis and distribution to nucleoplasmic speckles is mediated by TonEBP/NFAT5 transcriptional activator. (PubMed id 18028879)9 Favale N.O....Fernandez Tome M.C. (2007)
    518. Effect of lamin A/C knockdown on osteoblast different iation and function. (PubMed id 18847334)9 Akter R....Duque G. (2009)
    519. LMNA mutations in cardiac transplant recipients. (PubMed id 15539782)9 Pethig K....Schmidt H.H. (2005)
    520. Progeroid syndrome with scleroderma-like skin changes associated with homozygous R435C LMNA mutation. (PubMed id 19842191)9 Madej-Pilarczyk A....Hausmanowa-Petrusewicz I. (2009)
    521. Lamin A Ser404 is a nuclear target of Akt phosphorylation in C2C12 cells. (PubMed id 18808171)9 Cenni V....Marmiroli S. (2008)
    522. Identification of cyclin D3 as a new interaction partner of lamin A/C. (PubMed id 17321498)9 Mariappan I....Parnaik V.K. (2007)
    523. Heart involvement in lamin A/C related diseases. (PubMed id 17067107)9 Ben Yaou R....Bonne G. (2006)
    524. Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration. (PubMed id 16478798)9 Bakay M....Hoffman E.P. (2006)
    525. Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. (PubMed id 14755334)9 Lammerding J....Lee R.T. (2004)
    526. Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects. (PubMed id 12898247)9 Verga L....Arbustini E. (2003)
    527. Molecular defects associated with antithrombin deficiency and dilated cardiomyopathy in a Japanese patient. (PubMed id 18480576)9 Fujimori Y....Kojima T. (2008)
    528. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. (PubMed id 18396346)9 Galiova G....Kozubek S. (2008)
    529. Lamin A/C and cardiac diseases. (PubMed id 16601451)9 Sylvius N. and Tesson F. (2006)
    530. Genetics of laminopathies. (PubMed id 15773749)9 Ben Yaou R....Bonne G. (2005)
    531. LMNA mutation position predicts organ system involvement in laminopathies. (PubMed id 15952983)9 Hegele R. (2005)
    532. Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. (PubMed id 15843432)9 Libotte T....Karakesisoglou I. (2005)
    533. Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography. (PubMed id 15475483)9 Taylor M.R....Mestroni L. (2004)
    534. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. (PubMed id 19165338)9 Hamirally S....Coen D.M. (2009)
    535. Novel LMNA mutation in atypical Werner syndrome presenting with ischemic disease. (PubMed id 19095983)9 Renard D....De Sandre-Giovannoli A. (2009)
    536. A case of Dunnigan-type familial partial lipodystrophy (FPLD) due to lamin A/C (LMNA) mutations complicated by end-stage renal disease. (PubMed id 19011997)9 Imachi H....Ishida T. (2009)
    537. Severe mandibuloacral dysplasia-associated lipodystrophy and progeria in a young girl with a novel homozygous Arg527Cys LMNA mutation. (PubMed id 18796515)9 Agarwal A.K....Garg A. (2008)
    538. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. (PubMed id 18182166)9 Wolf C.M....Seidman J.G. (2008)
    539. Does satellite cell dysfunction contribute to disease progression in Emery-Dreifuss muscular dystrophy? (PubMed id 19021553)9 Gnocchi V.F....Zammit P.S. (2008)
    540. Nuclear envelope defects in muscular dystrophy. (PubMed id 16904876)9 Roux K.J. and Burke B. (2007)
    541. Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. (PubMed id 17164264)9 Heydemann A....McNally E.M. (2007)
    542. The retinol acid receptor B gene is hypermethylated in patients with familial partial lipodystrophy. (PubMed id 17556535)9 Cortese R....Brune T. (2007)
    543. Compound heterozygosity for mutations in LMNA in a patient with a myopathic and lipodystrophic mandibuloacral dysplasia type A phenotype. (PubMed id 17848409)9 Lombardi F....Novelli G. (2007)
    544. Phenotypic clustering of lamin A/C mutations in neuromuscular patients. (PubMed id 17377071)9 Benedetti S....Previtali S.C. (2007)
    545. A LMNA splicing mutation in two sisters with severe Dunnigan-type familial partial lipodystrophy type 2. (PubMed id 16636128)9 Morel C.F....Hegele R.A. (2006)
    546. A homozygous ZMPSTE24 null mutation in combination wi th a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS. (PubMed id 16671095)9 Denecke J....Marquardt T. (2006)
    547. Dominant LMNA mutations can cause combined muscular dystrophy and peripheral neuropathy. (PubMed id 15965218)9 Benedetti S....Previtali S.C. (2005)
    548. [Autosomal dominant limb-girdle muscular dystrophy associated with conduction defects (LGMD1B): a description of 8 new families with the LMNA gene mutations] (PubMed id 15678000)9 Ben Yaou R....Bonne G. (2005)
    549. A single-base mutation in the peroxisome proliferator-activated receptor gamma4 promoter associated with altered in vitro expression and partial lipodystrophy. (PubMed id 15531525)9 Al-Shali K....Hegele R.A. (2004)
    550. c-Jun and Sp1 family are critical for retinoic acid induction of the lamin A/C retinoic acid-responsive element. (PubMed id 15219855)9 Okumura K....Nakajima N. (2004)
    551. Immunocytochemistry of nuclear domains and Emery-Dreifuss muscular dystrophy pathophysiology. (PubMed id 12685553)9 Maraldi N.M....Squarzoni S. (2003)
    552. Mistargeting of B-type lamins at the end of mitosis: implications on cell survival and regulation of lamins A/C expression. (PubMed id 11331311)9 Steen R.L. and Collas P. (2001)
    553. Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy. (PubMed id 11470279)9 Wolff N....Zinn-Justin S. (2001)
    554. Common genomic variation in LMNA modulates indexes of obesity in Inuit. (PubMed id 11397881)9 Hegele R.A....Young T.K. (2001)
    555. Identification of a novel retinoic acid-responsive el ement within the lamin A/C promoter. (PubMed id 10694499)9 Okumura K....Nakajima N. (2000)
    556. Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression. (PubMed id 10364436)9 Pierce T....Holy J. (1999)
    557. Homozygous LMNA mutation R527C in atypical Hutchinson -Gilford progeria syndrome: evidence for autosomal recessive inheritance. (PubMed id 19432833)9 Liang L....Gu X. (2009)
    558. Phenomics and lamins: from disease to therapy. (PubMed id 17466974)9 Hegele R.A. and Oshima J. (2007)
    559. No mutation was detected in the LMNA gene among sporadic Charcot-Marie-Tooth patients. (PubMed id 16415973)9 Song S.J....Zhong N. (2006)
    560. Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. (PubMed id 15867203)9 Agrelo R....Esteller M. (2005)
    561. Silencing lamin A/C in human endometrial stromal cells: a model to investigate endometrial gene function and regulation. (PubMed id 15347737)9 Tulac S....Giudice L.C. (2004)
    562. Cardiac features of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutations. (PubMed id 14659775)9 Sanna T....Bellocci F. (2003)
    563. Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation. (PubMed id 14600514)9 Caron M....Capeau J. (2003)
    564. Emery-Dreifuss muscular dystrophy: a novel mutation i n the LMNA gene. (PubMed id 19589462)9 LassuthovA! P....Seeman P. (2009)
    565. Lipodystrophy: an unusual diagnosis in a case of olig omenorrhea and hirsutism. (PubMed id 19622949)9 Keller J....Garg A. (2009)
    566. Nuclear changes in skeletal muscle extend to satellite cells in autosomal dominant Emery-Dreifuss muscular dystrophy/limb-girdle muscular dystrophy 1B. (PubMed id 19070492)9 Park Y.E....Nishino I. (2009)
    567. Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells. (PubMed id 19449340)9 Butler J.T....Lawrence J.B. (2009)
    568. Proteomic analysis of protein complexes in human SH-S Y5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase i n lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopam ine-induced oxidative stress. (PubMed id 19264120)9 Nakamura M....Toda T. (2009)
    569. Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice. (PubMed id 19014358)9 de Carlos F....Cobo J.M. (2008)
    570. Altered distribution of lamin and emerin in muscle nuclei of sIBM patients. (PubMed id 19130741)9 Fidzianska A....Niebroj-Dobosz I. (2008)
    571. Clinical presentation and genetic analysis of a five generation Chinese family with isolated left ventricular noncompaction. (PubMed id 18379140)9 Xia S....Tang X. (2008)
    572. Desmin immunolocalisation in autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 17329105)9 Piercy R.J....Brown S.C. (2007)
    573. Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma. (PubMed id 17299075)9 Monajemi H....Leff T. (2007)
    574. Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity. (PubMed id 17761684)9 Zhang Q.... Shanahan C.M. (2007)
    575. Altered splicing in prelamin A-associated premature aging phenotypes. (PubMed id 17076270)9 De Sandre-Giovannoli A. and LAcvy N. (2006)
    576. Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation. (PubMed id 16825282)9 Verstraeten V.L....van den Wijngaard A. (2006)
    577. A new POLG1 mutation with peo and severe axonal and demyelinating sensory-motor neuropathy. (PubMed id 16715201)9 Santoro L....Santorelli F.M. (2006)
    578. Co-segregation of LMNA and PMP22 gene mutations in the same family. (PubMed id 16288874)9 Pegoraro E....Angelini C. (2005)
    579. Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C. (PubMed id 16320084)9 Wong S.P....Pinkney J.H. (2005)
    580. Lessons from human mutations in PPARgamma. (PubMed id 15711581)9 Hegele R.A. (2005)
    581. The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype. (PubMed id 11839786)9 Fairley E.A....Kendrick-Jones J. (2002)
    582. Functional domains of the nucleus: implications for Emery-Dreifuss muscular dystrophy. (PubMed id 12398831)9 Maraldi N.M....Squarzoni S. (2002)
    583. Expression of intermediate filament proteins in TPA-induced MPC-11 and HL-60 cells. (PubMed id 1544377)9 Paulin-Levasseur M. and Julien M. (1992)
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    587. Proteomic analysis of human adipose tissue after rosi glitazone treatment shows coordinated changes to promote glucose uptake. (PubMed id 19556978)9 Ahmed M....Karpe F. (2010)
    588. Nesprin-1 mutations in human and murine cardiomyopath y. (PubMed id 19944109)9 Puckelwartz M.J....McNally E.M. (2010)
    589. Muscle magnetic resonance imaging involvement in musc ular dystrophies with rigidity of the spine. (PubMed id 20225280)9 Mercuri E....Muntoni F. (2010)
    590. Efficacy of leptin therapy in the different forms of human lipodystrophy. (PubMed id 19727665)9 Chong A.Y....Gorden P. (2010)
    591. Incontinetia pigmenti-related myopathy or unsolved 'double trouble'? (PubMed id 20064724)9 Huttner H.B....SchrAPder R. (2010)
    592. Higher adiponectin levels in patients with Berardinel li-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol- 3-phosphate-o-acyltransferase-2 deficiency. (PubMed id 20097706)9 Antuna-Puente B....MagrAc J. (2010)
    593. Differential protein mapping of ovarian serous adenoc arcinomas: identification of potential markers for distinct tumor stage. (PubMed id 19159301)9 Wang Y....Lubman D.M. (2009)
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    598. Telomere length in Hutchinson-Gilford progeria syndrome. (PubMed id 19428457)9 Decker M.L....Lansdorp P.M. (2009)
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    601. Changes in the proteome of human bronchial epithelial cells following stimulation with leucotriene E4 and transforming growth factor-beta1. (PubMed id 19144047)9 Altraja S....Altraja A. (2009)
    602. Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines. (PubMed id 19082486)9 Stravopodis D.J....Voutsinas G.E. (2009)
    603. Congenital muscular dystrophy. Part I: a review of phenotypical and diagnostic aspects. (PubMed id 19330236)9 Reed U.C. (2009)
    604. The posttranslational processing of prelamin A and di sease. (PubMed id 19453251)9 Davies B.S....Young S.G. (2009)
    605. Inherited lipodystrophies and hypertriglyceridemia. (PubMed id 19494770)9 Simha V. and Garg A. (2009)
    606. Mechanical properties of interphase nuclei probed by cellular strain application. (PubMed id 18951177)9 Lammerding J. and Lee R.T. (2009)
    607. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. (PubMed id 19156760)9 Gruber-Olipitz M....Lubec G. (2009)
    608. Autophagic degradation of nuclear components in mamma lian cells. (PubMed id 19550147)9 Park Y.E....Nishino I. (2009)
    609. Laminopathies and the long strange trip from basic ce ll biology to therapy. (PubMed id 19587457)9 Worman H.J....Young S.G. (2009)
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    612. Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. (PubMed id 18846424)9 Nguyen N....Ahn J.Y. (2009)
    613. Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses. (PubMed id 19578756)9 Konstantakou E.G....Stravopodis D.J. (2009)
    614. Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model. (PubMed id 19379495)9 Coutinho H.D....da NA^brega R.B. (2009)
    615. Gliotoxin reverses age-dependent nuclear morphology p henotypes, ameliorates motility, but fails to affect lifespan of adult Caenorha bditis elegans. (PubMed id 19235201)9 Bar D.Z....Gruenbaum Y. (2009)
    616. Automated DNA mutation detection using universal cond itions direct sequencing: application to ten muscular dystrophy genes. (PubMed id 19835634)9 Bennett R.R....Kunkel L.M. (2009)
    617. The role of the nuclear lamins in the pathogenesis of heart failure in patients undergoing cardiac transplantation. (PubMed id 19715882)9 CortAcs R....PortolAcs M. (2009)
    618. Atypical generalized lipoatrophy and severe insulin resistance due to a heterozygous LMNA p.T10I mutation. (PubMed id 19169477)9 Mory P.B....MoisAcs R.S. (2008)
    619. Drug-specific effect of nelfinavir and stavudine on primary culture of human preadipocytes. (PubMed id 18344876)9 Saillan-Barreau C....PAcnicaud L. (2008)
    620. Phenotype and course of Hutchinson-Gilford progeria syndrome. (PubMed id 18256394)9 Merideth M.A....Introne W.J. (2008)
    621. Investigating the pathology of Emery-Dreifuss muscular dystrophy. (PubMed id 19021551)9 Brown S.C....Sewry C.A. (2008)
    622. Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy. (PubMed id 18672969)9 Meurs K.M....Norgard M.M. (2008)
    623. Molecular signatures of Emery-Dreifuss muscular dystrophy. (PubMed id 19021555)9 Wheeler M.A. and Ellis J.A. (2008)
    624. Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings. (PubMed id 18435794)9 Miyoshi Y....Ozono K. (2008)
    625. Reversible phenotype in a mouse model of Hutchinson-Gilford progeria syndrome. (PubMed id 18708427)9 Sagelius H....Eriksson M. (2008)
    626. Increased release and activity of matrix metalloproteinase-9 in patients with mandibuloacral dysplasia type A, a rare premature ageing syndrome. (PubMed id 18554282)9 Lombardi F....Novelli G. (2008)
    627. Nuclear localization of a novel human syntaxin 1B isoform. (PubMed id 18691641)9 Pereira S....Szepetowski P. (2008)
    628. The integrity of a lamin-B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells. (PubMed id 18334554)9 Tang C.W....Jackson D.A. (2008)
    629. Lamin A/C, laminopathies and premature ageing. (PubMed id 18366013)9 Liu B. and Zhou Z. (2008)
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    631. Granulocytic nuclear differentiation of lamin B receptor-deficient mouse EPRO cells. (PubMed id 18495328)9 Zwerger M....Olins D.E. (2008)
    632. Is autophagy rather than apoptosis the regression driver in imatinib-treated gastrointestinal stromal tumors? (PubMed id 19043528)9 Miselli F....Pilotti S. (2008)
    633. Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin. (PubMed id 18728124)9 Gambineri A....Pasquali R. (2008)
    634. Prematurely aged children: molecular alterations lead ing to Hutchinson-Gilford progeria and Werner syndromes. (PubMed id 20021393)9 DomA-nguez-Gerpe L. and Araujo-Vilar D. (2008)
    635. Leptin therapy for partial lipodystrophy linked to a PPAR-gamma mutation. (PubMed id 18076675)9 Guettier J.M....Gorden P. (2008)
    636. The human granulocyte nucleus: Unusual nuclear envelope and heterochromatin composition. (PubMed id 18396345)9 Olins A.L....Olins D.E. (2008)
    637. Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data. (PubMed id 18796670)9 Koikkalainen J.R....Peuhkurinen K.J. (2008)
    638. Effects of heat shock on the distribution and expression levels of nuclear proteins in HeLa S3 cells. (PubMed id 18980230)9 Haddad N. and Paulin-Levasseur M. (2008)
    639. Histopathological findings in hereditary motor and sensory neuropathy of axonal type with onset in early childhood associated with mitofusin 2 mutations. (PubMed id 18957892)9 Vallat J.M....Funalot B. (2008)
    640. Comparative proteomics analysis of Barrett metaplasia and esophageal adenocarcinoma using two-dimensional liquid mass mapping. (PubMed id 16829691)9 Zhao J....Lubman D.M. (2007)
    641. The nuclear envelope, a key structure in cellular integrity and gene expression. (PubMed id 17504143)9 Verstraeten V.L....van Steensel M.A. (2007)
    642. p53 targets identified by protein expression profiling. (PubMed id 17372198)9 Rahman-Roblick R....Wiman K.G. (2007)
    643. Phenomics, lamin A/C, and metabolic disease. (PubMed id 18056782)9 Hegele R.A. (2007)
    644. Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays. (PubMed id 17954908)9 Hudson M.E....Snyder M. (2007)
    645. Severe myocardial fibrosis caused by a deletion of the 5' end of the lamin A/C gene. (PubMed id 17599607)9 van Tintelen J.P....Pinto Y.M. (2007)
    646. Toxicogenetics of antiretroviral therapy: genetic factors that contribute to metabolic complications. (PubMed id 18018758)9 Tarr P.E. and Telenti A. (2007)
    647. Genetic forms of the cardiometabolic syndrome: what can they tell the clinician? (PubMed id 17684446)9 Yuan G. and Hegele R.A. (2007)
    648. Mid-myocardial fibrosis by cardiac magnetic resonance in patients with lamin A/C cardiomyopathy: possible substrate for diastolic dysfunction. (PubMed id 18066751)9 Raman S.V....Wooley C.F. (2007)
    649. Q2ChIP, a quick and quantitative chromatin immunoprecipitation assay, unravels epigenetic dynamics of developmentally regulated genes in human carcinoma cells. (PubMed id 17272500)9 Dahl J.A. and Collas P. (2007)
    650. [Primary lipodystrophies] (PubMed id 17320032)9 Capeau J....Vigouroux C. (2007)
    651. Cytomegaloviral proteins pUL50 and pUL53 are associated with the nuclear lamina and interact with cellular protein kinase C. (PubMed id 17872514)9 Milbradt J....Marschall M. (2007)
    652. An association of Hutchinson-Gilford progeria and malignancy. (PubMed id 17618517)9 Shalev S.A....Levy N. (2007)
    653. Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes. (PubMed id 17949487)9 Wiersma A.C....Dukes-McEwan J. (2007)
    654. Nucleoplasmic lamins and their interaction partners, LAP2alpha, Rb, and BAF, in transcriptional regulation. (PubMed id 17489094)9 Dorner D....Foisner R. (2007)
    655. 'Laminopathies': a wide spectrum of human diseases. (PubMed id 17467691)9 Worman H.J. and Bonne G. (2007)
    656. A novel mutation in limb girdle muscular dystrophy. (PubMed id 18035816)9 Correa M. and GA^mez C.G. (2007)
    657. [Hutchinson-Gilford progeria syndrome: clinical and molecular analysis in an African patient] (PubMed id 17511383)9 Mutesa L....Bours V. (2007)
    658. The nuclear lamina. Both a structural framework and a platform for genome organization. (PubMed id 17489093)9 Bridger J.M....Herrmann H. (2007)
    659. A pathogenic mechanism leading to partial lipodistrophy and prospects for pharmacological treatment of insulin resistance syndrome. (PubMed id 17465333)9 Maraldi N.M....Lattanzi G. (2007)
    660. Muscle and nerve pathology in Dunnigan familial partial lipodystrophy. (PubMed id 17325275)9 Spuler S....Schmidt H.H. (2007)
    661. Autosomal recessive axonal Charcot-Marie-Tooth disease (ARCMT2): phenotype-genotype correlations in 13 Moroccan families. (PubMed id 17347251)9 Bouhouche A....LeGuern E. (2007)
    662. Chromosome protein framework from proteome analysis of isolated human metaphase chromosomes. (PubMed id 17663445)9 Fukui K. and Uchiyama S. (2007)
    663. Primary laminopathy fibroblasts display altered genome organization and apoptosis. (PubMed id 17274801)9 Meaburn K.J....Bridger J.M. (2007)
    664. Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. (PubMed id 17896003)9 Nitta R.T....Kennedy B.K. (2007)
    665. Novel LMNA mutation in a Taiwanese family with autosomal dominant Emery-Dreifuss muscular dystrophy. (PubMed id 17493893)9 Liang W.C....Jong Y.J. (2007)
    666. Disease severity in dominant Emery Dreifuss is increased by mutations in both emerin and desmin proteins. (PubMed id 16585054)9 Muntoni F....Brown S.C. (2006)
    667. Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins. (PubMed id 17074834)9 Maeshima K....Imamoto N. (2006)
    668. Genetic basis of lipodystrophies and management of metabolic complications. (PubMed id 16409151)9 Agarwal A.K. and Garg A. (2006)
    669. Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. (PubMed id 16801550)9 Dahl K.N....Misteli T. (2006)
    670. Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies. (PubMed id 16584978)9 Maraldi N.M....Manzoli F.A. (2006)
    671. [Lipodystrophic syndromes: congenital or acquired diseases of adipose tissue] (PubMed id 16860281)9 Capeau J....Bastard J.P. (2006)
    672. Werner syndrome and mutations of the WRN and LMNA genes in France. (PubMed id 16786514)9 Uhrhammer N.A....Bignon Y.J. (2006)
    673. Morphological and immunocytochemical characterization of snake-like chromatin cells. (PubMed id 16437380)9 Jirsova K....Filipec M. (2006)
    674. Aging: progeria and the lamin connection. (PubMed id 16920618)9 Kudlow B.A. and Kennedy B.K. (2006)
    675. [Differential proteomic expression in human liver cells stimulated by hydroquinone] (PubMed id 17181942)9 Ju L....Yao G.D. (2006)
    676. Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest. (PubMed id 16809772)9 Nitta R.T....Kennedy B.K. (2006)
    677. Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. (PubMed id 17114944)9 Hossbach M....Tuschl T. (2006)
    678. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. (PubMed id 17152860)9 Agarwal A.K....Garg A. (2006)
    679. Myofiber degeneration in autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) (LGMD1B). (PubMed id 17107595)9 Mittelbronn M....Bornemann A. (2006)
    680. Molecular genetics of autosomal-recessive axonal Charcot-Marie-Tooth neuropathies. (PubMed id 16775369)9 Bernard R....Levy N. (2006)
    681. [Hutchinson-Gilford progeria in the light of contemporary genetics] (PubMed id 17028399)9 Madej-Pilarczyk A. (2006)
    682. Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. (PubMed id 16949164)9 Nakamura M....Toda T. (2006)
    683. Laminopathies: multisystem dystrophy syndromes. (PubMed id 16364671)9 Jacob K.N. and Garg A. (2006)
    684. Myofibrillar myopathy with congenital cataract and skeletal anomalies without mutations in the desmin, alphaB-crystallin, myotilin, LMNA or SEPN1 genes. (PubMed id 17005401)9 Kostera-Pruszczyk A....Fidzianska A. (2006)
    685. X-linked form of Emery-Dreifuss muscular dystrophy. (PubMed id 16550925)9 Hayashi Y.K. (2005)
    686. Hepatic steatosis in Dunnigan-type familial partial lipodystrophy. (PubMed id 16181372)9 LA1dtke A....Schmidt H.H. (2005)
    687. Nuclear envelopathies--raising the nuclear veil. (PubMed id 15817509)9 Somech R....Simon A.J. (2005)
    688. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. (PubMed id 16014412)9 Yang S.H....Fong L.G. (2005)
    689. Components of the nuclear envelope and their role in human disease. (PubMed id 15773746)9 Worman H.J. (2005)
    690. A-type lamin-linked lipodystrophies. (PubMed id 15773753)9 Vigouroux C. and Capeau J. (2005)
    691. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. (PubMed id 16247757)9 Taylor M.R....Mestroni L. (2005)
    692. HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. (PubMed id 16184025)9 Kudlow B.A....Kennedy B.K. (2005)
    693. A new LMNA mutation causing limb girdle muscular dystrophy 1B. (PubMed id 15789136)9 Spuler S....Schmidt H. (2005)
    694. Genetic and physiological insights into the metabolic syndrome. (PubMed id 15890790)9 Hegele R.A. and Pollex R.L. (2005)
    695. Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome. (PubMed id 16186497)9 Mallampalli M.P....Michaelis S. (2005)
    696. Altered pre-lamin A processing is a common mechanism leading to lipodystrophy. (PubMed id 15843404)9 Capanni C....Lattanzi G. (2005)
    697. Gene mutations in adult Japanese patients with dilated cardiomyopathy. (PubMed id 15671604)9 Shimizu M....Mabuchi H. (2005)
    698. Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. (PubMed id 16199031)9 Kivinen K....Taimen P. (2005)
    699. Phenotypic heterogeneity in body fat distribution in patients with atypical Werner's syndrome due to heterozygous Arg133Leu lamin A/C mutation. (PubMed id 16174718)9 Jacob K.N....Garg A. (2005)
    700. A-type nuclear lamins, progerias and other degenerative disorders. (PubMed id 15722103)9 Smith E.D....Kennedy B.K. (2005)
    701. Identification of differentially expressed proteins in oral squamous cell carcinoma using a global proteomic approach. (PubMed id 15942644)9 Koike H....Tanzawa H. (2005)
    702. [Monogenic severe insulin resistance syndromes] (PubMed id 15908053)9 Vincent-Desplanques D....Vantyghem M.C. (2005)
    703. [Laminopathies: lipodystrophies, insulin resistance, syndromes of accelerated ageing... and others] (PubMed id 15988390)9 Vigouroux C. (2005)
    704. Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome. (PubMed id 15756215)9 Gordon L.B....Lichtenstein A.H. (2005)
    705. Extreme variability of skeletal and cardiac muscle involvement in patients with mutations in exon 11 of the lamin A/C gene. (PubMed id 15770669)9 Mercuri E....Muntoni F. (2005)
    706. Sequestration of pRb by cyclin D3 causes intranuclear reorganization of lamin A/C during muscle cell differentiation. (PubMed id 15703219)9 Mariappan I. and Parnaik V.K. (2005)
    707. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. (PubMed id 16079796)9 Varela I....Lopez-Otin C. (2005)
    708. Differential protein expression in anatomical zones of the prostate. (PubMed id 15892163)9 Lexander H....Egevad L. (2005)
    709. Diseases of adipose tissue: genetic and acquired lipodystrophies. (PubMed id 16246048)9 Capeau J....Bastard J.P. (2005)
    710. Electrophysiological and histopathological characteristics of progressive atrioventricular block accompanied by familial dilated cardiomyopathy caused by a novel mutation of lamin A/C gene. (PubMed id 15720451)9 Otomo J....Shirato K. (2005)
    711. Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy. (PubMed id 15773758)9 Kozlov S....Stewart C.L. (2005)
    712. Molecular etiopathogenesis of limb girdle muscular and congenital muscular dystrophies: boundaries and contiguities. (PubMed id 16002060)9 Guglieri M....Comi G.P. (2005)
    713. [Familial dilated cardiomyopathy] (PubMed id 16170685)9 Osterziel K.J....Perrot A. (2005)
    714. Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. (PubMed id 16208517)9 Huang S....Oshima J. (2005)
    715. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. (PubMed id 16046620)9 Filesi I....Novelli G. (2005)
    716. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. (PubMed id 15750600)9 Scaffidi P. and Misteli T. (2005)
    717. Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. (PubMed id 16261260)9 Columbaro M....Lattanzi G. (2005)
    718. Long-term treatment experience in a subject with Dunnigan-type familial partial lipodystrophy: efficacy of rosiglitazone. (PubMed id 16241930)9 LA1dtke A....Schmidt H.H. (2005)
    719. Patients with familial partial lipodystrophy of the Dunnigan type due to a LMNA R482W mutation show muscular and cardiac abnormalities. (PubMed id 15531479)9 Vantyghem M.C....Vigouroux C. (2004)
    720. Hutchinson-Gilford progeria syndrome. (PubMed id 15479179)9 Pollex R.L. and Hegele R.A. (2004)
    721. Cytoskeletal influences on nuclear shape in granulocy tic HL-60 cells. (PubMed id 15317658)9 Olins A.L. and Olins D.E. (2004)
    722. Aging and nuclear organization: lamins and progeria. (PubMed id 15145358)9 Mounkes L.C. and Stewart C.L. (2004)
    723. Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina. (PubMed id 15292200)9 Panorchan P....Tseng Y. (2004)
    724. Laminopathies: from the heart of the cell to the clinics. (PubMed id 15367859)9 Benedetti S. and Merlini L. (2004)
    725. Disruption of spermatogenesis in mice lacking A-type lamins. (PubMed id 14996939)9 Alsheimer M....Benavente R. (2004)
    726. Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation. (PubMed id 15053843)9 Reichart B....Dabauvalle M.C. (2004)
    727. Gene expression profiling of fibroblasts from a human progeroid disease (mandibuloacral dysplasia, MAD #248370) through cDNA microarrays. (PubMed id 15473259)9 Amati F....Novelli G. (2004)
    728. Mesangiocapillary glomerulonephritis type 2 associated with familial partial lipodystrophy (Dunnigan-Kobberling syndrome). (PubMed id 14988595)9 Owen K.R....Bingham C. (2004)
    729. Abnormal cell cycle regulation in primary human uveal melanoma cultures. (PubMed id 15660415)9 Pardo M....Capeans C. (2004)
    730. Pathological changes of the myonuclear fibrous lamina and internal nuclear membrane in two cases of autosomal dominant limb-girdle muscular dystrophy with atrioventricular conduction disturbance (LGMD1B). (PubMed id 14673599)9 Matsubara S. and Kitaguchi T. (2004)
    731. The congenital and limb-girdle muscular dystrophies: sharpening the focus, blurring the boundaries. (PubMed id 14967765)9 Kirschner J. and Bonnemann C.G. (2004)
    732. Clinical proteomics in lung diseases. (PubMed id 15237923)9 Waldburg N....Buhling F. (2004)
    733. [Cardiac manifestations of laminopathies] (PubMed id 16008174)9 Brette S....Victor J. (2004)
    734. Phenomics, lipodystrophy, and the metabolic syndrome. (PubMed id 15177263)9 Hegele R.A. (2004)
    735. [Limb girdle muscular dystrophies] (PubMed id 15316618)9 Finsterer J. (2004)
    736. LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome. (PubMed id 15121795)9 Fukuchi K....Ogihara T. (2004)
    737. Temporal and spatial variations in structural protein expression during the progression from stunned to hibernating myocardium. (PubMed id 15545518)9 Thijssen V.L....Canty J.M. (2004)
    738. NuMA and nuclear lamins are cleaved during viral infection--inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death. (PubMed id 15003865)9 Taimen P....Kallajoki M. (2004)
    739. Etiological investigation of diabetes in young adults presenting with apparent type 2 diabetes. (PubMed id 12832318)9 Owen K.R....Hattersley A.T. (2003)
    740. Familial atrial fibrillation is a genetically heterogeneous disorder. (PubMed id 12821245)9 Darbar D....Olson T.M. (2003)
    741. A genome-wide scan for body mass index among Nigerian families. (PubMed id 12582223)9 Adeyemo A....Ward R. (2003)
    742. Risk factors for diabetes in familial partial lipodystrophy, Dunnigan variety. (PubMed id 12716787)9 Haque W.A....Garg A. (2003)
    743. LMNA mutations in atypical Werner's syndrome. (PubMed id 14615128)9 Vigouroux C....Cohen A. (2003)
    744. [The laminopathy saga] (PubMed id 14593639)9 Bonne G. (2003)
    745. Protein defects in neuromuscular diseases. (PubMed id 12715073)9 Vainzof M. and Zatz M. (2003)
    746. LMNA mutations in atypical Werner's syndrome. (PubMed id 14615129)9 Bonne G. and Levy N. (2003)
    747. Monogenic forms of insulin resistance: apertures that expose the common metabolic syndrome. (PubMed id 14516935)9 Hegele R.A. (2003)
    748. Lamin A/C truncation in dilated cardiomyopathy with conduction disease. (PubMed id 12854972)9 MacLeod H.M....McNally E.M. (2003)

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    Entrez Gene: 4000 HGNC: 6636 AceView: LMNA Ensembl:ENSG00000160789 euGenes: HUgn4000
    ECgene: LMNA Kegg: 4000 H-InvDB: LMNA

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    PharmGKB entry for LMNA Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for LMNA Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LMNA

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