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Aliases for LMLN Gene

Aliases for LMLN Gene

  • Leishmanolysin Like Peptidase 2 3 5
  • Leishmanolysin-Like (Metallopeptidase M8 Family) 2 3
  • Invadolysin 3 4
  • Leishmanolysin-Like Peptidase 3
  • Leishmanolysin-2 3
  • EC 3.4.24.- 4
  • GP63 3
  • IX14 3
  • INV 3
  • MSP 3

External Ids for LMLN Gene

Previous GeneCards Identifiers for LMLN Gene

  • GC03U990224
  • GC03P199086
  • GC03P199013
  • GC03P199175
  • GC03P197687
  • GC03P194989

Summaries for LMLN Gene

Entrez Gene Summary for LMLN Gene

  • This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for LMLN Gene

LMLN (Leishmanolysin Like Peptidase) is a Protein Coding gene. Diseases associated with LMLN include Visceral Leishmaniasis and Cutaneous Leishmaniasis. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is LOC100128908.

UniProtKB/Swiss-Prot for LMLN Gene

  • Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMLN Gene

Genomics for LMLN Gene

Regulatory Elements for LMLN Gene

Enhancers for LMLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F198030 0.8 Ensembl 11.8 +70.1 70101 0.6 TBP HDAC1 CREB3L1 ZNF175 FOXK2 ZSCAN29 NFE2 CREM ZNF639 L3MBTL2 RNU6-621P LMLN PIR53898
GH03F197982 0.6 Ensembl 0.3 +22.3 22301 0.2 HDGF MTA2 CBFB IKZF1 HLF ZBTB33 MLLT1 IQCG RPL35A GC03P197995 LMLN
GH03F197984 0.4 Ensembl 0.3 +24.7 24701 0.2 ZNF316 SPI1 IQCG RPL35A GC03P197995 LMLN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMLN on UCSC Golden Path with GeneCards custom track

Promoters for LMLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001384263 500 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143

Genomic Location for LMLN Gene

Chromosome:
3
Start:
197,960,200 bp from pter
End:
198,043,720 bp from pter
Size:
83,521 bases
Orientation:
Plus strand

Genomic View for LMLN Gene

Genes around LMLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMLN Gene

Proteins for LMLN Gene

  • Protein details for LMLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KR4-LMLN_HUMAN
    Recommended name:
    Leishmanolysin-like peptidase
    Protein Accession:
    Q96KR4
    Secondary Accessions:
    • B3LDG9
    • B3LDH0
    • C9J796
    • F8WB28
    • Q96KR5

    Protein attributes for LMLN Gene

    Size:
    655 amino acids
    Molecular mass:
    73568 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMLN Gene

Post-translational modifications for LMLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMLN Gene

Domains & Families for LMLN Gene

Protein Domains for LMLN Gene

Suggested Antigen Peptide Sequences for LMLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KR4

UniProtKB/Swiss-Prot:

LMLN_HUMAN :
  • Belongs to the peptidase M8 family.
Family:
  • Belongs to the peptidase M8 family.
genes like me logo Genes that share domains with LMLN: view

No data available for Gene Families for LMLN Gene

Function for LMLN Gene

Molecular function for LMLN Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

Enzyme Numbers (IUBMB) for LMLN Gene

Gene Ontology (GO) - Molecular Function for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LMLN: view
genes like me logo Genes that share phenotypes with LMLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMLN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LMLN Gene

Localization for LMLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMLN Gene

Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMLN gene
Compartment Confidence
cytosol 5
plasma membrane 2
lysosome 2
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005811 lipid particle IEA --
GO:0005925 focal adhesion IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMLN: view

Pathways & Interactions for LMLN Gene

No Data Available

Interacting Proteins for LMLN Gene

Gene Ontology (GO) - Biological Process for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007155 cell adhesion IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with LMLN: view

No data available for Pathways by source and SIGNOR curated interactions for LMLN Gene

Drugs & Compounds for LMLN Gene

(2) Drugs for LMLN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LMLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LMLN: view

Transcripts for LMLN Gene

Unigene Clusters for LMLN Gene

Leishmanolysin-like (metallopeptidase M8 family):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMLN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: -
SP5:

Relevant External Links for LMLN Gene

GeneLoc Exon Structure for
LMLN
ECgene alternative splicing isoforms for
LMLN

Expression for LMLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMLN Gene

Protein differential expression in normal tissues from HIPED for LMLN Gene

This gene is overexpressed in Serum (61.4) and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMLN Gene



Protein tissue co-expression partners for LMLN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMLN Gene:

LMLN

SOURCE GeneReport for Unigene cluster for LMLN Gene:

Hs.518540

mRNA Expression by UniProt/SwissProt for LMLN Gene:

Q96KR4-LMLN_HUMAN
Tissue specificity: Expressed in all cell lines analyzed.
genes like me logo Genes that share expression patterns with LMLN: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LMLN Gene

Orthologs for LMLN Gene

This gene was present in the common ancestor of animals.

Orthologs for LMLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMLN 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia LMLN 34 35
  • 90.22 (n)
cow
(Bos Taurus)
Mammalia LMLN 34 35
  • 90.07 (n)
mouse
(Mus musculus)
Mammalia Lmln 34 16 35
  • 84.61 (n)
rat
(Rattus norvegicus)
Mammalia Lmln 34
  • 84.15 (n)
oppossum
(Monodelphis domestica)
Mammalia LMLN 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMLN 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMLN 34 35
  • 75.87 (n)
lizard
(Anolis carolinensis)
Reptilia LMLN 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lmln 34 35
  • 68.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002955 34
  • 52.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Invadolysin 34 35
  • 50.98 (n)
l(3)IX-14 36
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y43F4A.1 36 34 35
  • 51.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for LMLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LMLN Gene

ENSEMBL:
Gene Tree for LMLN (if available)
TreeFam:
Gene Tree for LMLN (if available)

Paralogs for LMLN Gene

Paralogs for LMLN Gene

Pseudogenes.org Pseudogenes for LMLN Gene

genes like me logo Genes that share paralogs with LMLN: view

Variants for LMLN Gene

Sequence variations from dbSNP and Humsavar for LMLN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193920933 Uncertain significance 197,996,244(+) GTGTG(G/T)GCACT nc-transcript-variant, reference, missense
rs10635029 -- 198,043,100(+) AAATA(-/AATA)TATCA nc-transcript-variant, utr-variant-3-prime
rs10644845 -- 198,025,290(+) AGAAT(-/TAAT)AAATC intron-variant
rs10662532 -- 198,039,654(+) TTGTT(-/TGTT)CTAAA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10662707 -- 198,039,653(+) TCCCA(-/TTGT)TTGTT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LMLN Gene

Variant ID Type Subtype PubMed ID
nsv999711 CNV gain 25217958
nsv997702 CNV gain 25217958
nsv821565 CNV deletion 20802225
nsv593167 CNV loss 21841781
nsv593165 CNV gain 21841781
nsv527527 CNV gain 19592680
nsv513109 CNV loss 21212237
nsv471882 CNV novel sequence insertion 20440878
nsv471160 CNV gain 18288195
nsv1152171 CNV duplication 26484159
nsv1115654 CNV duplication 24896259
nsv10404 CNV gain 18304495
nsv10403 CNV gain+loss 18304495
nsv1013844 CNV gain 25217958
nsv1009299 CNV gain 25217958
esv3893858 CNV gain 25118596
esv3893857 CNV loss 25118596
esv3893855 CNV gain 25118596
esv3599333 CNV gain 21293372
esv3599332 CNV gain 21293372
esv3599331 CNV gain 21293372
esv3599329 CNV gain 21293372
esv3599324 CNV gain 21293372
esv3575649 CNV gain 25503493
esv3569236 CNV loss 25503493
esv3563197 CNV deletion 23714750
esv33797 CNV gain+loss 17666407
esv3330249 CNV insertion 20981092
esv2763718 CNV gain+loss 21179565
esv2762376 CNV gain 21179565
esv2751989 CNV gain 17911159
esv26014 CNV gain+loss 19812545
esv24855 CNV loss 19812545
esv2126673 CNV deletion 18987734
esv1531702 CNV deletion 17803354
esv1010170 CNV loss 20482838
dgv8869n54 CNV gain 21841781
dgv8868n54 CNV loss 21841781
dgv8867n54 CNV loss 21841781
dgv8866n54 CNV gain 21841781
dgv8865n54 CNV gain 21841781
dgv5046n100 CNV gain 25217958
dgv5045n100 CNV gain 25217958
dgv5044n100 CNV gain 25217958

Variation tolerance for LMLN Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMLN Gene

Disorders for LMLN Gene

MalaCards: The human disease database

(4) MalaCards diseases for LMLN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
visceral leishmaniasis
  • infection by visceral leishmaniasis
cutaneous leishmaniasis
  • asian desert cutaneous leishmaniasis
leishmaniasis
  • post kala-azar dermal leishmaniasis
parasitic protozoa infectious disease
  • mastigophora infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search LMLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for LMLN

Human Genome Epidemiology (HuGE) Navigator
LMLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMLN
genes like me logo Genes that share disorders with LMLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMLN Gene

Publications for LMLN Gene

  1. The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. (PMID: 19706689) Cobbe N. … Heck M.M. (J. Cell Sci. 2009) 3 4 22 64
  2. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. (PMID: 15557119) McHugh B. … Heck M.M. (J. Cell Biol. 2004) 3 4 22 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3 64
  5. Protein levels of CC chemokine ligand (CCL)15, CCL16 and macrophage stimulating protein in patients with sarcoidosis. (PMID: 19220835) Arakelyan A. … Petrek M. (Clin. Exp. Immunol. 2009) 22 64

Products for LMLN Gene

Sources for LMLN Gene

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