Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LMLN Gene

Aliases for LMLN Gene

  • Leishmanolysin Like Peptidase 2 3
  • Leishmanolysin-Like (Metallopeptidase M8 Family) 2 3 5
  • Invadolysin 3 4
  • Leishmanolysin-2 3
  • EC 3.4.24.- 4
  • GP63 3
  • IX14 3
  • INV 3
  • MSP 3

External Ids for LMLN Gene

Previous GeneCards Identifiers for LMLN Gene

  • GC03U990224
  • GC03P199086
  • GC03P199013
  • GC03P199175
  • GC03P197687
  • GC03P194989

Summaries for LMLN Gene

Entrez Gene Summary for LMLN Gene

  • This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for LMLN Gene

LMLN (Leishmanolysin Like Peptidase) is a Protein Coding gene. Diseases associated with LMLN include Nephronophthisis 2, Infantile and Visceral Leishmaniasis. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for LMLN Gene

  • Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMLN Gene

Genomics for LMLN Gene

Regulatory Elements for LMLN Gene

Enhancers for LMLN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMLN on UCSC Golden Path with GeneCards custom track

Promoters for LMLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LMLN on UCSC Golden Path with GeneCards custom track

Genomic Location for LMLN Gene

197,960,200 bp from pter
198,043,720 bp from pter
83,521 bases
Plus strand

Genomic View for LMLN Gene

Genes around LMLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMLN Gene

Proteins for LMLN Gene

  • Protein details for LMLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leishmanolysin-like peptidase
    Protein Accession:
    Secondary Accessions:
    • B3LDG9
    • B3LDH0
    • C9J796
    • F8WB28
    • Q96KR5

    Protein attributes for LMLN Gene

    655 amino acids
    Molecular mass:
    73568 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMLN Gene


neXtProt entry for LMLN Gene

Proteomics data for LMLN Gene at MOPED

Post-translational modifications for LMLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LMLN Gene

No data available for DME Specific Peptides for LMLN Gene

Domains & Families for LMLN Gene

Protein Domains for LMLN Gene

Suggested Antigen Peptide Sequences for LMLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M8 family.
  • Belongs to the peptidase M8 family.
genes like me logo Genes that share domains with LMLN: view

No data available for Gene Families for LMLN Gene

Function for LMLN Gene

Molecular function for LMLN Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

Enzyme Numbers (IUBMB) for LMLN Gene

genes like me logo Genes that share phenotypes with LMLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMLN

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LMLN Gene

Localization for LMLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMLN Gene

Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.

Subcellular locations from

Jensen Localization Image for LMLN Gene COMPARTMENTS Subcellular localization image for LMLN gene
Compartment Confidence
cytosol 3
plasma membrane 2
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LMLN: view

Pathways & Interactions for LMLN Gene

SuperPathways for LMLN Gene

No Data Available

Interacting Proteins for LMLN Gene

Selected Interacting proteins: Q96KR4-LMLN_HUMAN for LMLN Gene via I2D

Gene Ontology (GO) - Biological Process for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with LMLN: view

No data available for Pathways by source and SIGNOR curated interactions for LMLN Gene

Drugs & Compounds for LMLN Gene

(2) Drugs for LMLN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LMLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LMLN: view

Transcripts for LMLN Gene

Unigene Clusters for LMLN Gene

Leishmanolysin-like (metallopeptidase M8 family):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMLN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - -
SP4: -

Relevant External Links for LMLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMLN Gene

mRNA expression in normal human tissues for LMLN Gene

Protein differential expression in normal tissues from HIPED for LMLN Gene

This gene is overexpressed in Serum (61.4) and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMLN Gene

SOURCE GeneReport for Unigene cluster for LMLN Gene Hs.518540

mRNA Expression by UniProt/SwissProt for LMLN Gene

Tissue specificity: Expressed in all cell lines analyzed.
genes like me logo Genes that share expression patterns with LMLN: view

Protein tissue co-expression partners for LMLN Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LMLN Gene

Orthologs for LMLN Gene

This gene was present in the common ancestor of animals.

Orthologs for LMLN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LMLN 35
  • 90.07 (n)
  • 91.49 (a)
  • 91 (a)
(Canis familiaris)
Mammalia LMLN 35
  • 90.22 (n)
  • 91.18 (a)
  • 88 (a)
(Mus musculus)
Mammalia Lmln 35
  • 84.61 (n)
  • 91.13 (a)
Lmln 16
Lmln 36
  • 90 (a)
(Pan troglodytes)
Mammalia LMLN 35
  • 99.47 (n)
  • 99.57 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Lmln 35
  • 84.15 (n)
  • 90.07 (a)
(Monodelphis domestica)
Mammalia LMLN 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia LMLN 36
  • 33 (a)
(Gallus gallus)
Aves LMLN 35
  • 75.87 (n)
  • 80.62 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia LMLN 36
  • 76 (a)
(Danio rerio)
Actinopterygii lmln 35
  • 68.31 (n)
  • 70.54 (a)
lmln 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)IX-14 37
  • 39 (a)
Invadolysin 35
  • 50.98 (n)
  • 46.23 (a)
Invadolysin 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002955 35
  • 52.29 (n)
  • 47.83 (a)
(Caenorhabditis elegans)
Secernentea Y43F4A.1 37
  • 38 (a)
Y43F4A.1 35
  • 51.1 (n)
  • 43.2 (a)
Y43F4A.1 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for LMLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LMLN Gene

Gene Tree for LMLN (if available)
Gene Tree for LMLN (if available)

Paralogs for LMLN Gene Pseudogenes for LMLN Gene

genes like me logo Genes that share paralogs with LMLN: view

No data available for Paralogs for LMLN Gene

Variants for LMLN Gene

Sequence variations from dbSNP and Humsavar for LMLN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7373165 - 197,975,042(+) TTCAG(G/T)TTGCT nc-transcript-variant, reference, missense
rs4058 -- 198,042,253(-) accgc(A/G)cccAC nc-transcript-variant, utr-variant-3-prime
rs7431003 -- 197,962,339(+) tccat(C/T)gaata intron-variant
rs9812528 -- 198,012,870(+) CTCTG(C/T)ACCCT intron-variant
rs9812535 -- 198,012,882(+) CAGAG(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMLN Gene

Variant ID Type Subtype PubMed ID
esv2751989 CNV Gain 17911159
nsv527527 CNV Gain 19592680
dgv5379n71 CNV Gain 21882294
nsv483023 CNV Gain 15286789
nsv878215 CNV Loss 21882294
nsv878216 CNV Gain 21882294
dgv5380n71 CNV Loss 21882294
nsv878218 CNV Gain 21882294
esv33797 CNV Gain+Loss 17666407
nsv878220 CNV Loss 21882294
nsv10403 CNV Gain+Loss 18304495
nsv513109 CNV Loss 21212237
esv1010170 CNV Loss 20482838
esv26014 CNV Gain+Loss 19812545
nsv821565 CNV Deletion 20802225
esv1531702 CNV Deletion 17803354
nsv10404 CNV Gain 18304495
nsv471160 CNV Gain 18288195
esv24855 CNV Loss 19812545
dgv5381n71 CNV Gain 21882294
esv2126673 CNV Deletion 18987734

Variation tolerance for LMLN Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LMLN Gene

Disorders for LMLN Gene

MalaCards: The human disease database

(5) MalaCards diseases for LMLN Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nephronophthisis 2, infantile
  • nephronophthisis 2
visceral leishmaniasis
  • infection by visceral leishmaniasis
  • cutaneous leishmaniasis
cutaneous leishmaniasis
  • asian desert cutaneous leishmaniasis
parasitic protozoa infectious disease
  • mastigophora infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search LMLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for LMLN

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LMLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMLN Gene

Publications for LMLN Gene

  1. The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. (PMID: 19706689) Cobbe N. … Heck M.M. (J. Cell Sci. 2009) 3 4 23 67
  2. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. (PMID: 15557119) McHugh B. … Heck M.M. (J. Cell Biol. 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3
  5. Protein levels of CC chemokine ligand (CCL)15, CCL16 and macrophage stimulating protein in patients with sarcoidosis. (PMID: 19220835) Arakelyan A. … Petrek M. (Clin. Exp. Immunol. 2009) 23

Products for LMLN Gene

Sources for LMLN Gene