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Aliases for LMLN Gene

Aliases for LMLN Gene

  • Leishmanolysin-Like (Metallopeptidase M8 Family) 2 3
  • Invadolysin 3 4
  • Leishmanolysin-Like Peptidase 3
  • Leishmanolysin-2 3
  • EC 3.4.24.- 4
  • GP63 3
  • IX14 3
  • MSP 3
  • INV 3

External Ids for LMLN Gene

Previous GeneCards Identifiers for LMLN Gene

  • GC03U990224
  • GC03P199086
  • GC03P199013
  • GC03P199175
  • GC03P197687
  • GC03P194989

Summaries for LMLN Gene

Entrez Gene Summary for LMLN Gene

  • This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for LMLN Gene

LMLN (Leishmanolysin-Like (Metallopeptidase M8 Family)) is a Protein Coding gene. Diseases associated with LMLN include esotropia and leishmaniasis. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot for LMLN Gene

  • Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMLN Gene

Genomics for LMLN Gene

Regulatory Elements for LMLN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LMLN Gene

Start:
197,960,200 bp from pter
End:
198,043,720 bp from pter
Size:
83,521 bases
Orientation:
Plus strand

Genomic View for LMLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMLN Gene

Proteins for LMLN Gene

  • Protein details for LMLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KR4-LMLN_HUMAN
    Recommended name:
    Leishmanolysin-like peptidase
    Protein Accession:
    Q96KR4
    Secondary Accessions:
    • B3LDG9
    • B3LDH0
    • C9J796
    • F8WB28
    • Q96KR5

    Protein attributes for LMLN Gene

    Size:
    655 amino acids
    Molecular mass:
    73568 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMLN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMLN Gene

Proteomics data for LMLN Gene at MOPED

Post-translational modifications for LMLN Gene

  • Glycosylation at Asn308 and Asn615
  • Modification sites at PhosphoSitePlus

Other Protein References for LMLN Gene

No data available for DME Specific Peptides for LMLN Gene

Domains for LMLN Gene

Protein Domains for LMLN Gene

Suggested Antigen Peptide Sequences for LMLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96KR4

UniProtKB/Swiss-Prot:

LMLN_HUMAN :
  • Q96KR4
Family:
  • Belongs to the peptidase M8 family.
genes like me logo Genes that share domains with LMLN: view

No data available for Gene Families for LMLN Gene

Function for LMLN Gene

Molecular function for LMLN Gene

UniProtKB/Swiss-Prot Function: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration.

Enzyme Numbers (IUBMB) for LMLN Gene

Gene Ontology (GO) - Molecular Function for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LMLN: view

Animal Model Products

CRISPR Products

miRNA for LMLN Gene

miRTarBase miRNAs that target LMLN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMLN

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LMLN Gene

Localization for LMLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMLN Gene

Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMLN Gene COMPARTMENTS Subcellular localization image for LMLN gene
Compartment Confidence
cytosol 3
plasma membrane 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005811 lipid particle IEA --
GO:0005925 focal adhesion IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LMLN: view

Pathways for LMLN Gene

SuperPathways for LMLN Gene

No Data Available

Interacting Proteins for LMLN Gene

Selected Interacting proteins: Q96KR4-LMLN_HUMAN for LMLN Gene via I2D

Gene Ontology (GO) - Biological Process for LMLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007155 cell adhesion IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with LMLN: view

No data available for Pathways by source for LMLN Gene

Compounds for LMLN Gene

(4) Novoseek inferred chemical compound relationships for LMLN Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 42.2 5
cycloheximide 16.1 2
zinc 8.76 2
cysteine 0 1
genes like me logo Genes that share compounds with LMLN: view

Transcripts for LMLN Gene

Unigene Clusters for LMLN Gene

Leishmanolysin-like (metallopeptidase M8 family):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMLN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LMLN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMLN Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: -
SP5:

Relevant External Links for LMLN Gene

GeneLoc Exon Structure for
LMLN
ECgene alternative splicing isoforms for
LMLN

Expression for LMLN Gene

mRNA expression in normal human tissues for LMLN Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LMLN Gene

SOURCE GeneReport for Unigene cluster for LMLN Gene Hs.518540

mRNA Expression by UniProt/SwissProt for LMLN Gene

Q96KR4-LMLN_HUMAN
Tissue specificity: Expressed in all cell lines analyzed.
genes like me logo Genes that share expressions with LMLN: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LMLN Gene

Orthologs for LMLN Gene

This gene was present in the common ancestor of animals.

Orthologs for LMLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMLN 35
  • 99.47 (n)
  • 99.57 (a)
LMLN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LMLN 35
  • 90.07 (n)
  • 91.49 (a)
LMLN 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMLN 35
  • 90.22 (n)
  • 91.18 (a)
LMLN 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmln 35
  • 84.61 (n)
  • 91.13 (a)
Lmln 16
Lmln 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMLN 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMLN 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmln 35
  • 84.15 (n)
  • 90.07 (a)
chicken
(Gallus gallus)
Aves LMLN 35
  • 75.87 (n)
  • 80.62 (a)
LMLN 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMLN 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lmln 35
  • 68.31 (n)
  • 70.54 (a)
lmln 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002955 35
  • 52.29 (n)
  • 47.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Invadolysin 35
  • 50.98 (n)
  • 46.23 (a)
Invadolysin 36
  • 41 (a)
OneToOne
l(3)IX-14 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y43F4A.1 35
  • 51.1 (n)
  • 43.2 (a)
Y43F4A.1 36
  • 37 (a)
OneToOne
Y43F4A.1 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for LMLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LMLN Gene

ENSEMBL:
Gene Tree for LMLN (if available)
TreeFam:
Gene Tree for LMLN (if available)

Paralogs for LMLN Gene

Pseudogenes.org Pseudogenes for LMLN Gene

genes like me logo Genes that share paralogs with LMLN: view

No data available for Paralogs for LMLN Gene

Variants for LMLN Gene

Sequence variations from dbSNP and Humsavar for LMLN Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4058 -- 198,042,253(-) accgc(A/G)cccAC utr-variant-3-prime, nc-transcript-variant
rs6422711 -- 198,023,782(+) TGTGC(A/T)TACTG intron-variant
rs6422712 -- 197,969,021(+) taaat(G/T)gctgg intron-variant
rs6605312 -- 197,999,424(+) GCTGA(C/T)ATTTT intron-variant
rs6605313 -- 198,010,947(+) tttga(A/C)ccatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMLN Gene

Variant ID Type Subtype PubMed ID
esv2751989 CNV Gain 17911159
nsv527527 CNV Gain 19592680
dgv5379n71 CNV Gain 21882294
nsv483023 CNV Gain 15286789
nsv878215 CNV Loss 21882294
nsv878216 CNV Gain 21882294
dgv5380n71 CNV Loss 21882294
nsv878218 CNV Gain 21882294
esv33797 CNV Gain+Loss 17666407
nsv878220 CNV Loss 21882294
nsv10403 CNV Gain+Loss 18304495
nsv513109 CNV Loss 21212237
esv1010170 CNV Loss 20482838
esv26014 CNV Gain+Loss 19812545
nsv821565 CNV Deletion 20802225
esv1531702 CNV Deletion 17803354
nsv10404 CNV Gain 18304495
nsv471160 CNV Gain 18288195
esv24855 CNV Loss 19812545
dgv5381n71 CNV Gain 21882294
esv2126673 CNV Deletion 18987734

Relevant External Links for LMLN Gene

HapMap Linkage Disequilibrium report
LMLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMLN Gene

Disorders for LMLN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for LMLN Gene including...

Search for LMLN Gene in MalaCards »

(2) University of Copenhagen DISEASES for LMLN Gene

(3) Novoseek inferred disease relationships for LMLN Gene

Disease -log(P) Hits PubMed IDs
leishmaniasis 78.7 3
leishmaniasis visceral 70.4 5
leishmaniasis cutaneous 61.7 1

Relevant External Links for LMLN

Human Genome Epidemiology (HuGE) Navigator
LMLN
genes like me logo Genes that share disorders with LMLN: view

No data available for UniProtKB/Swiss-Prot for LMLN Gene

Publications for LMLN Gene

  1. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. (PMID: 15557119) McHugh B. … Heck M.M. (J. Cell Biol. 2004) 3 4 23
  2. The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. (PMID: 19706689) Cobbe N. … Heck M.M. (J. Cell Sci. 2009) 3 4 23
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for LMLN Gene

Sources for LMLN Gene

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