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LMLN Gene

protein-coding   GIFtS: 50
GCID: GC03P197687

Leishmanolysin-Like (Metallopeptidase M8 Family)

  See LMLN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leishmanolysin-Like (Metallopeptidase M8 Family)1 2     invadolysin2
GP632     leishmanolysin-22
INV2     Leishmanolysin-Like Peptidase2
IX142     EC 3.4.24.-3
MSP2     Invadolysin3

External Ids:    HGNC: 159911   Entrez Gene: 897822   Ensembl: ENSG000001856217   OMIM: 6093805   UniProtKB: Q96KR43   

Export aliases for LMLN gene to outside databases

Previous GC identifers: GC03U990224 GC03P199086 GC03P199013 GC03P199175 GC03P194989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LMLN Gene:
This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion.
Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively
spliced transcript variants have been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for LMLN Gene:
LMLN (leishmanolysin-like (metallopeptidase M8 family)) is a protein-coding gene. Diseases associated with LMLN include esotropia, and leishmaniasis. GO annotations related to this gene include metalloendopeptidase activity.

UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
Function: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell
migration (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMLN gene promoter:
         AhR   AML1a   NRSF form 1   NRSF form 2   Arnt   MEF-2A   AREB6   Zic1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMLN promoter sequence
   Search Chromatin IP Primers for LMLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

LMLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMLN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P197687:  view genomic region     (about GC identifiers)

Start:
197,687,071 bp from pter      End:
197,770,591 bp from pter
Size:
83,521 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4 (See protein sequence)
Recommended Name: Leishmanolysin-like peptidase  
Size: 655 amino acids; 73568 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: B3LDG9 B3LDH0 C9J796 F8WB28 Q96KR5
Alternative splicing: 3 isoforms:  Q96KR4-1   Q96KR4-2   Q96KR4-3   

Explore the universe of human proteins at neXtProt for LMLN: NX_Q96KR4

Explore proteomics data for LMLN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn308, Asn615
  • Modification sites at PhosphoSitePlus

  • See LMLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129521.2  NP_149018.2  

    ENSEMBL proteins: 
     ENSP00000418324   ENSP00000328829   ENSP00000390872   ENSP00000410926   ENSP00000328611  

    LMLN Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LMLN

     
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    Search eBioscience for ELISAs for LMLN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001577 Peptidase_M8

    Graphical View of Domain Structure for InterPro Entry Q96KR4

    ProtoNet protein and cluster: Q96KR4

    1 Blocks protein domain: IPB001577 Leishmanolysin (M8) metalloprotease family signature

    UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
    Similarity: Belongs to the peptidase M8 family


    Find genes that share domains with LMLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMLN_HUMAN, Q96KR4
    Function: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell
    migration (By similarity)

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with LMLN           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Lmln (no phenotypes)

    Find genes that share phenotypes with LMLN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMLN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMLN

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMLN:
    hsa-mir-335-5p (MIRT018194), hsa-let-7e-5p (MIRT051516), hsa-mir-192-5p (MIRT026528)

    Block miRNA regulation of human, mouse, rat LMLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMLN (see all 89):
    hsa-miR-3607-3p hsa-miR-134 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-3074-3p hsa-miR-30a hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMLN_HUMAN, Q96KR4: Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In
    migrating cells it relocalizes from internal structures to the leading edge of cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005811lipid particle IEA--
    GO:0005925focal adhesion IDA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with LMLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LMLN
    Interactions:

        Search GeneGlobe Interaction Network for LMLN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for LMLN (Q96KR43 ENSP000004109264) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKHD1Q8IWZ33I2D: score=5 
    COASYQ130573I2D: score=5 
    NOSIPQ9Y3143I2D: score=5 
    PAHP004393I2D: score=5 
    PHKA2P460193I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007067mitosis IEA--
    GO:0007155cell adhesion IEA--

    Find genes that share ontologies with LMLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMLN

    4 Novoseek inferred chemical compound relationships for LMLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 42.2 5 2191040 (5)
    cycloheximide 16.1 3 8340397 (2)
    zinc 8.76 2 8626468 (2)
    cysteine 0 1 11770107 (1)



    Find genes that share compounds with LMLN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LMLN gene (2 alternative transcripts): 
    NM_001136049.2  NM_033029.3  

    Unigene Cluster for LMLN:

    Leishmanolysin-like (metallopeptidase M8 family)
    Hs.518540  [show with all ESTs]
    Unigene Representative Sequence: NM_001136049
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482695 ENST00000330198(uc010iar.3 uc003fyt.3 uc011buo.2 uc010ias.3 uc003fyu.3)
    ENST00000419117 ENST00000451139 ENST00000420910 ENST00000332636 ENST00000482837
    ENST00000473676 ENST00000472063 ENST00000476356 ENST00000480813
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMLN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LMLN (see all 89):
    hsa-miR-3607-3p hsa-miR-134 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-3074-3p hsa-miR-30a hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for LMLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LMLN (NM_033029)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMLN
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat LMLN
      QuantiFast Probe-based Assays in human, mouse, rat LMLN

    Additional mRNA sequence: 

    AJ312398.1 AJ312399.1 AK299119.1 AL832783.1 AM920777.1 AM920778.1 NR_026786.1 NR_026787.1 

    6 DOTS entries:

    DT.40208951  DT.91817169  DT.86852434  DT.452399  DT.75117598  DT.100658885 

    Selected AceView cDNA sequences (see all 99):

    BM979906 BM977281 AW002381 BE218604 CA418513 BM763015 AJ312399 Z39948 
    AJ312398 F03790 AA778757 BM887648 CA776220 BM840400 AA665493 BQ573980 
    CD105294 NM_033029 F03167 F03899 F03791 AI675303 BI825808 BE891940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LMLN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                       -                 -           -                             -           -                                       
    SP2:                                -                 -           -                             -           -     -                                 
    SP3:                                                                                                                                                
    SP4:                                                                                            -                                                   
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LMLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LMLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTGCAGC
    LMLN Expression
    About this image

    LMLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518540

    UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
    Tissue specificity: Expressed in all cell lines analyzed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LMLN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmln1 , 5 leishmanolysin-like (metallopeptidase M8 family)1, 5 84.61(n)1
    91.13(a)1
      16 (23.60 cM)5
    2398331  NM_172823.21  NP_766411.11 
     330625215 
    chicken
    (Gallus gallus)
    Aves LMLN1 leishmanolysin-like (metallopeptidase M8 family) 75.87(n)
    80.62(a)
      424264  XM_422111.4  XP_422111.3 
    lizard
    (Anolis carolinensis)
    Reptilia LMLN6
    leishmanolysin-like (metallopeptidase M8 family)
    76(a)
    1 ↔ 1
    1(77558584-77587889)
    zebrafish
    (Danio rerio)
    Actinopterygii lmln1 leishmanolysin-like (metallopeptidase M8 family) 68.31(n)
    70.54(a)
      560606  XM_684004.5  XP_689096.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)IX-143
    Invadolysin1
    metalloendopeptidase3
    Invadolysin1
    39(a)3
    50.98(n)1
    46.23(a)1
      495801  NM_143815.41  NP_652072.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43F4A.11 , 3 zinc metallopeptidase (M8 family)3
    Y43F4A.11
    38(a)3
    51.1(n)1
    43.2(a)1
      III(13294438-13300600)3
    1767371  NM_001027699.31  NP_001022870.11 


    ENSEMBL Gene Tree for LMLN (if available)
    TreeFam Gene Tree for LMLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LMLN gene

    Find genes that share paralogs with LMLN           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LMLN
    PGOHUM00000236712


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LMLN (see all 1647)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842168511,2
    C--197688984(+) CAGACA/G/TTTCCC 4 -- int10--------
    rs1888527701,2
    --197689052(+) TTTTTA/TAATAC 4 -- int10--------
    rs1913333661,2
    --197689107(+) TTATAC/TGGTAT 4 -- int10--------
    rs344773021,2
    C--197689180(+) TAATT-/TATTCC 4 -- int10--------
    rs74310031,2
    C,F,A,H--197689210(+) tccatT/Cgaata 4 -- int121Minor allele frequency- C:0.47EA NS NA WA CSA 2122
    rs1846070211,2
    --197689266(+) ATTTTG/TGTTTC 4 -- int10--------
    rs1902385061,2
    --197689477(+) TTATGA/GTTGCT 4 -- int10--------
    rs1824731081,2
    --197689511(+) CTTTCG/TAAGAA 4 -- int10--------
    rs767645641,2
    C--197689512(+) TTTCTA/GAGAAA 4 -- int13Minor allele frequency- G:0.06CSA WA NA 240
    rs1438509161,2
    --197689613(+) ATATAC/TGATGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for LMLN (197687071 - 197770591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LMLN (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821565CNV Deletion20802225
    esv2126673CNV Deletion18987734
    esv1531702CNV Deletion17803354
    nsv878215CNV Loss21882294
    dgv5380n71CNV Loss21882294
    nsv513109CNV Loss21212237
    esv1010170CNV Loss20482838
    esv24855CNV Loss19812545
    nsv878220CNV Loss21882294
    nsv10404CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609380    OMIM disorders: --

    3 diseases for LMLN:    
    About MalaCards
    esotropia    leishmaniasis    congenital nystagmus

    2 diseases from the University of Copenhagen DISEASES database for LMLN:
    Congenital nystagmus     Esotropia

    Find genes that share disorders with LMLN           About GenesLikeMe

    3 Novoseek inferred disease relationships for LMLN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leishmaniasis 78.7 3 7678627 (2), 7750991 (1)
    leishmaniasis visceral 70.4 6 8004810 (3), 1940356 (1), 7678428 (1)
    leishmaniasis cutaneous 61.7 1 8004810 (1)

    Human Genome Epidemiology (HuGE) Navigator: LMLN (1 document)

    Export disorders for LMLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LMLN gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with LMLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. (PubMed id 19706689)1, 2, 9 Cobbe N.... Heck M.M. (J. Cell Sci. 2009)
    2. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. (PubMed id 15557119)1, 2, 9 McHugh B....Heck M.M. (J. Cell Biol. 2004)
    3. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. Interaction of Leishmania gp63 with cellular receptors for fibronectin. (PubMed id 10456889)9 Brittingham A....Mosser D.M. (Infect. Immun. 1999)
    7. Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis. (PubMed id 7673725)9 Brittingham A....Mosser D.M. (J. Immunol. 1995)
    8. Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes. (PubMed id 17693594)9 Yao C....Wilson M.E. (Eukaryotic Cell 2007)
    9. Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein. (PubMed id 12137567)9 Corradin S....MauAl J. (Biochem. J. 2002)
    10. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit. (PubMed id 8626468)9 McGwire B.S. and Chang K.P. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89782 HGNC: 15991 AceView: LMLN Ensembl:ENSG00000185621 euGenes: HUgn89782
    ECgene: LMLN H-InvDB: LMLN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LMLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LMLN gene:
    Search GeneIP for patents involving LMLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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