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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMLN Gene

protein-coding   GIFtS: 49
GCID: GC03P197687

Leishmanolysin-Like (Metallopeptidase M8 Family)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Leishmanolysin-Like (Metallopeptidase M8 Family)1 2     invadolysin2
GP632     leishmanolysin-22
INV2     Leishmanolysin-Like Peptidase2
IX142     EC 3.4.24.-3
MSP2     Invadolysin3

External Ids:    HGNC: 159911   Entrez Gene: 897822   Ensembl: ENSG000001856217   OMIM: 6093805   UniProtKB: Q96KR43   
ORGUL members:         
NONCODE14:n407319      

Export aliases for LMLN gene to outside databases

Previous GC identifers: GC03U990224 GC03P199086 GC03P199013 GC03P199175 GC03P194989


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMLN Gene:
This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion.
Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively
spliced transcript variants have been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for LMLN Gene: 
LMLN (leishmanolysin-like (metallopeptidase M8 family)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with LMLN include visceral leishmaniasis, and exotropia. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding.

UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
Function: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell
migration (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMLN gene promoter:
         AhR   AML1a   NRSF form 1   NRSF form 2   Arnt   MEF-2A   AREB6   Zic1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMLN promoter sequence
   Search SABiosciences Chromatin IP Primers for LMLN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

LMLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMLN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P197687:  view genomic region     (about GC identifiers)

Start:
197,687,071 bp from pter      End:
197,770,591 bp from pter
Size:
83,521 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4 (See protein sequence)
Recommended Name: Leishmanolysin-like peptidase  
Size: 655 amino acids; 73568 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Cytoplasm. Lipid droplet. Note=Found in ring-like structures resembling invadopodia. In
migrating cells it relocalizes from internal structures to the leading edge of cells
Secondary accessions: B3LDG9 B3LDH0 C9J796 F8WB28 Q96KR5
Alternative splicing: 3 isoforms:  Q96KR4-1   Q96KR4-2   Q96KR4-3   

Explore the universe of human proteins at neXtProt for LMLN: NX_Q96KR4

Explore proteomics data for LMLN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96KR4

  • LMLN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMLN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129521.2  NP_149018.2  

    ENSEMBL proteins: 
     ENSP00000418324   ENSP00000328829   ENSP00000390872   ENSP00000410926   ENSP00000328611  

    Human Recombinant Protein Products for LMLN: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LMLN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005811lipid particle IEA--
    GO:0005925focal adhesion IDA--
    GO:0016020membrane IEA--

    LMLN for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001577 Peptidase_M8

    Graphical View of Domain Structure for InterPro Entry Q96KR4

    ProtoNet protein and cluster: Q96KR4

    1 Blocks protein domain: IPB001577 Leishmanolysin (M8) metalloprotease family signature

    UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
    Similarity: Belongs to the peptidase M8 family


    LMLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMLN_HUMAN, Q96KR4
    Function: Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell
    migration (By similarity)

         Enzyme Number (IUBMB): EC 3.4.24.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    LMLN for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Lmln (no phenotypes)

    LMLN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMLN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMLN 
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    miRNA
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    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate LMLN (see all 89):
    hsa-miR-3607-3p hsa-miR-134 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-3074-3p hsa-miR-30a hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LMLN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/10 Interacting proteins for LMLN (Q96KR43 ENSP000004109264) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKHD1Q8IWZ33I2D: score=5 
    COASYQ130573I2D: score=5 
    NOSIPQ9Y3143I2D: score=5 
    PAHP004393I2D: score=5 
    PHKA2P460193I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007067mitosis IEA--
    GO:0007155cell adhesion IEA--
    GO:0051301cell division IEA--

    LMLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LMLN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMLN

    4 Novoseek inferred chemical compound relationships for LMLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 42.2 5 2191040 (5)
    cycloheximide 16.1 3 8340397 (2)
    zinc 8.76 2 8626468 (2)
    cysteine 0 1 11770107 (1)

    Search CenterWatch for drugs/clinical trials and news about LMLN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LMLN gene (2 alternative transcripts): 
    NM_001136049.2  NM_033029.3  

    Unigene Cluster for LMLN:

    Leishmanolysin-like (metallopeptidase M8 family)
    Hs.518540  [show with all ESTs]
    Unigene Representative Sequence: NM_001136049
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482695 ENST00000330198(uc010iar.3 uc003fyt.3 uc011buo.2 uc010ias.3 uc003fyu.3)
    ENST00000419117 ENST00000451139 ENST00000420910 ENST00000332636 ENST00000482837
    ENST00000473676 ENST00000472063 ENST00000476356 ENST00000480813
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMLN
    8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate LMLN (see all 89):
    hsa-miR-3607-3p hsa-miR-134 hsa-miR-200a hsa-miR-30d hsa-miR-374a hsa-miR-3074-3p hsa-miR-30a hsa-miR-508-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LMLN
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMLN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMLN

    Additional mRNA sequence: 

    AJ312398.1 AJ312399.1 AK299119.1 AL832783.1 AM920777.1 AM920778.1 NR_026786.1 NR_026787.1 

    6 DOTS entries:

    DT.40208951  DT.91817169  DT.86852434  DT.452399  DT.75117598  DT.100658885 

    24/99 AceView cDNA sequences (see all 99):

    AA778757 BM840400 AW002381 BQ573980 F03899 CD105294 F03167 AJ312398 
    BM979906 BM763015 AA665493 BM977281 F03791 F03790 BE218604 BM887648 
    Z39948 NM_033029 CA776220 AJ312399 CA418513 BF223162 Z43883 AI967988 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LMLN    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:        -                       -                 -           -                             -           -                                       
    SP2:                                -                 -           -                             -           -     -                                 
    SP3:                                                                                                                                                
    SP4:                                                                                            -                                                   
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for LMLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTGCAGC
    LMLN Expression
    About this image


    See LMLN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMLN

    SOURCE GeneReport for Unigene cluster: Hs.518540

    UniProtKB/Swiss-Prot: LMLN_HUMAN, Q96KR4
    Tissue specificity: Expressed in all cell lines analyzed

        SABiosciences Custom PCR Arrays for LMLN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMLN gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmln1 , 5 leishmanolysin-like (metallopeptidase M8 family)1, 5 84.29(n)1
    90.31(a)1
      16 (23.60 cM)5
    2398331  NM_172823.21  NP_766411.11 
     330625215 
    chicken
    (Gallus gallus)
    Aves LMLN1 leishmanolysin-like (metallopeptidase M8 family) 74.77(n)
    79.28(a)
      424264  XM_422111.3  XP_422111.3 
    lizard
    (Anolis carolinensis)
    Reptilia LMLN6
    Uncharacterized protein
    74(a)
    1 ↔ 1
    1(77558584-77587889)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606061 novel protein similar to human and mouse leishmanolysin-like more 68.31(n)
    70.54(a)
      560606  XM_684004.4  XP_689096.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)IX-143
    Invadolysin1
    metalloendopeptidase3
    CG3953-PA1
    39(a)3
    51.11(n)1
    46.5(a)1
      495801  NM_143815.31  NP_652072.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y43F4A.11 , 3 zinc metallopeptidase (M8 family)3
    Protein Y43F4A.11
    38(a)3
    51.1(n)1
    43.2(a)1
      III(13294438-13300600)3
    1767371  NM_001027699.21  NP_001022870.11 


    ENSEMBL Gene Tree for LMLN (if available)
    TreeFam Gene Tree for LMLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMLN gene

    LMLN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LMLN
    PGOHUM00000236712


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1647 SNPs in LMLN are shown (see all 1647)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842168511,2
    C--197688984(+) CAGACA/G/TTTCCC 4 -- int10--------
    rs1888527701,2
    --197689052(+) TTTTTA/TAATAC 4 -- int10--------
    rs1913333661,2
    --197689107(+) TTATAC/TGGTAT 4 -- int10--------
    rs344773021,2
    C--197689180(+) TAATT-/TATTCC 4 -- int10--------
    rs74310031,2
    C,F,A,H--197689210(+) tccatT/Cgaata 4 -- int121Minor allele frequency- C:0.47EA NS NA WA CSA 2122
    rs1846070211,2
    --197689266(+) ATTTTG/TGTTTC 4 -- int10--------
    rs1902385061,2
    --197689477(+) TTATGA/GTTGCT 4 -- int10--------
    rs1824731081,2
    --197689511(+) CTTTCG/TAAGAA 4 -- int10--------
    rs767645641,2
    C--197689512(+) TTTCTA/GAGAAA 4 -- int13Minor allele frequency- G:0.06CSA WA NA 240
    rs1438509161,2
    --197689613(+) ATATAC/TGATGT 4 -- int10--------

    HapMap Linkage Disequilibrium report for LMLN (197687071 - 197770591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for LMLN (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821565CNV Deletion20802225
    esv2126673CNV Deletion18987734
    esv1531702CNV Deletion17803354
    nsv878215CNV Loss21882294
    dgv5380n71CNV Loss21882294
    nsv513109CNV Loss21212237
    esv1010170CNV Loss20482838
    esv24855CNV Loss19812545
    nsv878220CNV Loss21882294
    nsv10404CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609380    OMIM disorders: --

    8 diseases for LMLN:    About MalaCards
    visceral leishmaniasis    exotropia    leishmaniasis    esotropia
    cutaneous leishmaniasis    congenital nystagmus    vaccinia    sarcoidosis

    2 diseases from the University of Copenhagen DISEASES database for LMLN:
    Congenital nystagmus     Esotropia

    LMLN for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for LMLN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leishmaniasis 78.7 3 7678627 (2), 7750991 (1)
    leishmaniasis visceral 70.4 6 8004810 (3), 1940356 (1), 7678428 (1)
    leishmaniasis cutaneous 61.7 1 8004810 (1)

    Human Genome Epidemiology (HuGE) Navigator: LMLN (1 document)

    Export disorders for LMLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMLN gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with LMLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved metalloprotease invadolysin localizes t o the surface of lipid droplets. (PubMed id 19706689)1, 2, 9 Cobbe N....Heck M.M. (2009)
    2. Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration. (PubMed id 15557119)1, 2, 9 McHugh B....Heck M.M. (2004)
    3. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    6. Interaction of Leishmania gp63 with cellular receptors for fibronectin. (PubMed id 10456889)9 Brittingham A....Mosser D.M. (1999)
    7. Role of the Leishmania surface protease gp63 in compl ement fixation, cell adhesion, and resistance to complement-mediated lysis. (PubMed id 7673725)9 Brittingham A....Mosser D.M. (1995)
    8. Internal and surface-localized major surface proteases of Leishmania spp. and their differential release from promastigotes. (PubMed id 17693594)9 Yao C....Wilson M.E. (2007)
    9. Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein. (PubMed id 12137567)9 Corradin S....Mauel J. (2002)
    10. Posttranslational regulation of a Leishmania HEXXH metalloprotease (gp63). The effects of site-specific mutagenesis of catalytic, zinc binding, N-glycosylation, and glycosyl phosphatidylinositol addition sites on N-terminal end cleavage, intracellular stability, and extracellular exit. (PubMed id 8626468)9 McGwire B.S. and Chang K.P. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89782 HGNC: 15991 AceView: LMLN Ensembl:ENSG00000185621 euGenes: HUgn89782
    ECgene: LMLN H-InvDB: LMLN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LMLN gene:
    Search GeneIP for patents involving LMLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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