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Aliases for LMF2 Gene

Aliases for LMF2 Gene

  • Lipase Maturation Factor 2 2 3 5
  • Transmembrane Protein 112B 2 3 4
  • Transmembrane Protein 153 2 3 4
  • TMEM112B 3 4
  • TMEM153 3 4

External Ids for LMF2 Gene

Previous HGNC Symbols for LMF2 Gene

  • TMEM153
  • TMEM112B

Previous GeneCards Identifiers for LMF2 Gene

  • GC22M049290
  • GC22M050941
  • GC22M033832

Summaries for LMF2 Gene

GeneCards Summary for LMF2 Gene

LMF2 (Lipase Maturation Factor 2) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and Metabolism. An important paralog of this gene is LMF1.

UniProtKB/Swiss-Prot for LMF2 Gene

  • Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMF2 Gene

Genomics for LMF2 Gene

Regulatory Elements for LMF2 Gene

Enhancers for LMF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G050505 1.1 ENCODE 15 0.0 -14 4.2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SYCE3 LMF2 TYMP MIOX LOC105377205 ARSA ENSG00000272940 NCAPH2
GH22G050483 1.2 ENCODE dbSUPER 12.6 +23.2 23166 3.2 MLX ARID4B E2F7 DMAP1 THRB ZNF48 RARA SIRT6 U2AF2 THAP11 NCAPH2 LMF2 CHKB MAPK8IP2 SYCE3 PPP6R2 DENND6B ARSA MIOX
GH22G050481 1.1 ENCODE dbSUPER 12.6 +25.9 25858 1.3 DRAP1 KLF1 USF1 SAP130 RBBP5 CEBPG EGR1 POLR2A PCBP1 EZH2 LMF2 NCAPH2 MAPK8IP2 CHKB MIOX ADM2
GH22G050504 0.5 ENCODE 23.7 +2.6 2589 0.7 HIC1 ZFHX2 ZNF692 RBFOX2 EGR2 LMF2 MIOX
GH22G050523 1.4 ENCODE dbSUPER 6.7 -21.9 -21865 12.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A SCO2 TYMP ENSG00000272821 SYCE3 ENSG00000272836 ALG12 ZBED4 LMF2 ENSG00000272940 RABL2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMF2 on UCSC Golden Path with GeneCards custom track

Promoters for LMF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147738 -160 2001 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SP3

Genomic Location for LMF2 Gene

Chromosome:
22
Start:
50,502,947 bp from pter
End:
50,507,840 bp from pter
Size:
4,894 bases
Orientation:
Minus strand

Genomic View for LMF2 Gene

Genes around LMF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMF2 Gene

Proteins for LMF2 Gene

  • Protein details for LMF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU23-LMF2_HUMAN
    Recommended name:
    Lipase maturation factor 2
    Protein Accession:
    Q9BU23
    Secondary Accessions:
    • A6NEZ0
    • Q13392
    • Q6ZNR2
    • Q8WU74
    • Q96C62

    Protein attributes for LMF2 Gene

    Size:
    707 amino acids
    Molecular mass:
    79698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85437.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for LMF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMF2 Gene

Post-translational modifications for LMF2 Gene

  • Ubiquitination at posLast=551551, posLast=563563, and posLast=607607
  • Modification sites at PhosphoSitePlus

Other Protein References for LMF2 Gene

No data available for DME Specific Peptides for LMF2 Gene

Domains & Families for LMF2 Gene

Protein Domains for LMF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU23

UniProtKB/Swiss-Prot:

LMF2_HUMAN :
  • Belongs to the lipase maturation factor family.
Family:
  • Belongs to the lipase maturation factor family.
genes like me logo Genes that share domains with LMF2: view

No data available for Gene Families for LMF2 Gene

Function for LMF2 Gene

Molecular function for LMF2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

Gene Ontology (GO) - Molecular Function for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LMF2: view

Phenotypes for LMF2 Gene

genes like me logo Genes that share phenotypes with LMF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LMF2 Gene

Localization for LMF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMF2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMF2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMF2: view

Pathways & Interactions for LMF2 Gene

genes like me logo Genes that share pathways with LMF2: view

Gene Ontology (GO) - Biological Process for LMF2 Gene

None

No data available for SIGNOR curated interactions for LMF2 Gene

Transcripts for LMF2 Gene

Unigene Clusters for LMF2 Gene

Lipase maturation factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:

Relevant External Links for LMF2 Gene

GeneLoc Exon Structure for
LMF2
ECgene alternative splicing isoforms for
LMF2

Expression for LMF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMF2 Gene

Protein differential expression in normal tissues from HIPED for LMF2 Gene

This gene is overexpressed in Nasal epithelium (30.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LMF2 Gene



Protein tissue co-expression partners for LMF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMF2 Gene:

LMF2

SOURCE GeneReport for Unigene cluster for LMF2 Gene:

Hs.150540

Evidence on tissue expression from TISSUES for LMF2 Gene

  • Skin(4.6)
  • Kidney(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with LMF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMF2 Gene

Orthologs for LMF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMF2 34 35
  • 85.43 (n)
dog
(Canis familiaris)
Mammalia LMF2 34 35
  • 82.08 (n)
mouse
(Mus musculus)
Mammalia Lmf2 34 16 35
  • 80.2 (n)
rat
(Rattus norvegicus)
Mammalia Lmf2 34
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia LMF2 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMF2 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMF2 34 35
  • 69.42 (n)
lizard
(Anolis carolinensis)
Reptilia LMF2 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmf2 34
  • 58.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53562 34
zebrafish
(Danio rerio)
Actinopterygii lmf2a 34 35
  • 61.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011922 34
  • 48.38 (n)
worm
(Caenorhabditis elegans)
Secernentea K11G12.6 34 35
  • 42.66 (n)
Species where no ortholog for LMF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMF2 Gene

ENSEMBL:
Gene Tree for LMF2 (if available)
TreeFam:
Gene Tree for LMF2 (if available)

Paralogs for LMF2 Gene

Paralogs for LMF2 Gene

genes like me logo Genes that share paralogs with LMF2: view

Variants for LMF2 Gene

Sequence variations from dbSNP and Humsavar for LMF2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs376748648 A breast cancer sample 50,506,927(+) GTCTC(A/C/G)GCGCT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, missense
rs1000482004 -- 50,508,098(+) CCCCC(-/T)CCTCC upstream-variant-2KB
rs1000906384 -- 50,507,287(+) TTCCA(A/G)GTCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001088754 -- 50,508,334(+) CTCCC(A/G)GACAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001294311 -- 50,508,204(+) GACAT(A/G)CGCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LMF2 Gene

Variant ID Type Subtype PubMed ID
esv2758852 CNV loss 17122850
nsv1057656 CNV gain 25217958
nsv1160782 CNV deletion 26073780
nsv3669 CNV insertion 18451855
nsv471224 CNV loss 18288195
nsv482079 CNV gain 20164927
nsv589222 CNV gain 21841781
nsv829340 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for LMF2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMF2 Gene

Disorders for LMF2 Gene

Relevant External Links for LMF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMF2

No disorders were found for LMF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMF2 Gene

Publications for LMF2 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment. (PMID: 26742120) Kobayashi N. … Kondo K. (PLoS ONE 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for LMF2 Gene

Sources for LMF2 Gene

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