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Aliases for LMF2 Gene

Aliases for LMF2 Gene

  • Lipase Maturation Factor 2 2 3
  • Transmembrane Protein 112B 2 3 4
  • Transmembrane Protein 153 2 3 4
  • TMEM112B 3 4
  • TMEM153 3 4

External Ids for LMF2 Gene

Previous HGNC Symbols for LMF2 Gene

  • TMEM153
  • TMEM112B

Previous GeneCards Identifiers for LMF2 Gene

  • GC22M049290
  • GC22M050941
  • GC22M033832

Summaries for LMF2 Gene

GeneCards Summary for LMF2 Gene

LMF2 (Lipase Maturation Factor 2) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. An important paralog of this gene is LMF1.

UniProtKB/Swiss-Prot for LMF2 Gene

  • Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMF2 Gene

Genomics for LMF2 Gene

Regulatory Elements for LMF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LMF2 Gene

Chromosome:
22
Start:
50,502,947 bp from pter
End:
50,507,840 bp from pter
Size:
4,894 bases
Orientation:
Minus strand

Genomic View for LMF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMF2 Gene

Proteins for LMF2 Gene

  • Protein details for LMF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU23-LMF2_HUMAN
    Recommended name:
    Lipase maturation factor 2
    Protein Accession:
    Q9BU23
    Secondary Accessions:
    • A6NEZ0
    • Q13392
    • Q6ZNR2
    • Q8WU74
    • Q96C62

    Protein attributes for LMF2 Gene

    Size:
    707 amino acids
    Molecular mass:
    79698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85437.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Alternative splice isoforms for LMF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMF2 Gene

Proteomics data for LMF2 Gene at MOPED

Post-translational modifications for LMF2 Gene

  • Ubiquitination at Lys 551, Lys 563, and Lys 607
  • Modification sites at PhosphoSitePlus

Other Protein References for LMF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LMF2 Gene

Domains & Families for LMF2 Gene

Protein Domains for LMF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LMF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU23

UniProtKB/Swiss-Prot:

LMF2_HUMAN :
  • Belongs to the lipase maturation factor family.
Family:
  • Belongs to the lipase maturation factor family.
genes like me logo Genes that share domains with LMF2: view

No data available for Gene Families for LMF2 Gene

Function for LMF2 Gene

Molecular function for LMF2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity).

Gene Ontology (GO) - Molecular Function for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LMF2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMF2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for LMF2 Gene

Localization for LMF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMF2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMF2 Gene COMPARTMENTS Subcellular localization image for LMF2 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for LMF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMF2: view

Pathways & Interactions for LMF2 Gene

genes like me logo Genes that share pathways with LMF2: view

Interacting Proteins for LMF2 Gene

Gene Ontology (GO) - Biological Process for LMF2 Gene

None

No data available for SIGNOR curated interactions for LMF2 Gene

Drugs & Compounds for LMF2 Gene

No Compound Related Data Available

Transcripts for LMF2 Gene

Unigene Clusters for LMF2 Gene

Lipase maturation factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - -
SP7: - -
SP8:

Relevant External Links for LMF2 Gene

GeneLoc Exon Structure for
LMF2
ECgene alternative splicing isoforms for
LMF2

Expression for LMF2 Gene

mRNA expression in normal human tissues for LMF2 Gene

Protein differential expression in normal tissues from HIPED for LMF2 Gene

This gene is overexpressed in Nasal epithelium (30.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMF2 Gene



SOURCE GeneReport for Unigene cluster for LMF2 Gene Hs.150540

genes like me logo Genes that share expression patterns with LMF2: view

Protein tissue co-expression partners for LMF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LMF2 Gene

Orthologs for LMF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMF2 35
  • 85.43 (n)
  • 86.02 (a)
LMF2 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMF2 35
  • 82.08 (n)
  • 80.11 (a)
LMF2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmf2 35
  • 80.2 (n)
  • 83.05 (a)
Lmf2 16
Lmf2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmf2 35
  • 79.65 (n)
  • 82.03 (a)
oppossum
(Monodelphis domestica)
Mammalia LMF2 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMF2 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMF2 35
  • 69.42 (n)
  • 65.82 (a)
LMF2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMF2 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmf2 35
  • 58.66 (n)
  • 57.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53562 35
zebrafish
(Danio rerio)
Actinopterygii lmf2a 35
  • 61.53 (n)
  • 58.32 (a)
lmf2a 36
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011922 35
  • 48.38 (n)
  • 33.78 (a)
worm
(Caenorhabditis elegans)
Secernentea K11G12.6 35
  • 42.66 (n)
  • 32.72 (a)
K11G12.6 36
  • 27 (a)
OneToMany
Species with no ortholog for LMF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMF2 Gene

ENSEMBL:
Gene Tree for LMF2 (if available)
TreeFam:
Gene Tree for LMF2 (if available)

Paralogs for LMF2 Gene

Paralogs for LMF2 Gene

genes like me logo Genes that share paralogs with LMF2: view

Variants for LMF2 Gene

Sequence variations from dbSNP and Humsavar for LMF2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs128941 -- 50,505,734(-) CGCTG(C/T)TGGAC reference, synonymous-codon, utr-variant-5-prime, nc-transcript-variant
rs743615 -- 50,505,699(-) GGCCA(C/T)GGCAG reference, synonymous-codon, utr-variant-5-prime, nc-transcript-variant
rs762669 -- 50,504,994(-) CCCAC(C/T)TGTCT intron-variant
rs762670 -- 50,504,581(-) TTGCG(C/T)CTGCT reference, synonymous-codon, nc-transcript-variant
rs762671 -- 50,504,575(-) CTGCT(G/T)CAGGG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LMF2 Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
dgv5063n71 CNV Loss 21882294
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
nsv3669 CNV Insertion 18451855
dgv5064n71 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897
dgv1422e1 CNV Complex 17122850
dgv5066n71 CNV Loss 21882294
nsv914552 CNV Loss 21882294
nsv482079 CNV Gain 20164927
nsv914554 CNV Loss 21882294
nsv829340 CNV Gain 20364138

Variation tolerance for LMF2 Gene

Residual Variation Intolerance Score: 56.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMF2 Gene

HapMap Linkage Disequilibrium report
LMF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMF2 Gene

Disorders for LMF2 Gene

Relevant External Links for LMF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMF2
genes like me logo Genes that share disorders with LMF2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMF2 Gene

Publications for LMF2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 67
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 67

Products for LMF2 Gene

Sources for LMF2 Gene

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