Aliases for LMCD1 Gene
External Ids for LMCD1 Gene
Previous GeneCards Identifiers for LMCD1 Gene
This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
GeneCards Summary for LMCD1 Gene
LMCD1 (LIM And Cysteine-Rich Domains 1) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is PRICKLE3.
UniProtKB/Swiss-Prot for LMCD1 Gene
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.