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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMCD1 Gene

protein-coding   GIFtS: 56
GCID: GC03P008518

LIM And Cysteine-Rich Domains 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM And Cysteine-Rich Domains 11 2
dyxin1 2
LIM And Cysteine-Rich Domains Protein 12
Dyxin3

External Ids:    HGNC: 66331   Entrez Gene: 299952   Ensembl: ENSG000000712827   OMIM: 6048595   UniProtKB: Q9NZU53   

Export aliases for LMCD1 gene to outside databases

Previous GC identifer: GC03P008472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMCD1 Gene:
This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an
N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement
in protein-protein interactions. The protein may act as a co-regulator of transcription along with other
transcription factors. Alternate splicing results in multiple transcript variants of this gene. (provided by
RefSeq, May 2013)

GeneCards Summary for LMCD1 Gene: 
LMCD1 (LIM and cysteine-rich domains 1) is a protein-coding gene. Diseases associated with LMCD1 include hepatocellular carcinoma. GO annotations related to this gene include transcription corepressor activity and zinc ion binding. An important paralog of this gene is PRICKLE3.

UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in
repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans
activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of
calcineurin/nuclear factor of activated T-cells signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMCD1 gene promoter:
         STAT1   p53   Bach2   AREB6   CREB   PPAR-gamma1   Nkx6-1   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMCD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LMCD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMCD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26-p24   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26-p24

LMCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMCD1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P008518:  view genomic region     (about GC identifiers)

Start:
8,543,393 bp from pter      End:
8,609,806 bp from pter
Size:
66,414 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5 (See protein sequence)
Recommended Name: LIM and cysteine-rich domains protein 1  
Size: 365 amino acids; 40833 Da
Subunit: Interacts with GATA1 and GATA4 (By similarity). Interacts with beta-dystroglycan. Interacts with GATA6
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=May shuttle between the cytoplasm
and the nucleus (By similarity)

Explore the universe of human proteins at neXtProt for LMCD1: NX_Q9NZU5

Explore proteomics data for LMCD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZU5

  • LMCD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMCD1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001265162.1  NP_001265163.1  NP_001265164.1  NP_055398.1  

    ENSEMBL proteins: 
     ENSP00000157600   ENSP00000400555   ENSP00000396515   ENSP00000405049   ENSP00000411222  
     ENSP00000441100   ENSP00000380542  

    Human Recombinant Protein Products for LMCD1: 
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    Novus Biologicals LMCD1 Proteins
    Novus Biologicals LMCD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LMCD1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--

    LMCD1 for ontologies           About GeneDecksing



    LMCD1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR010442 PET_domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q9NZU5

    ProtoNet protein and cluster: Q9NZU5

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB010442 PET


    UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
    Domain: The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6 (By similarity)
    Similarity: Contains 2 LIM zinc-binding domains
    Similarity: Contains 1 PET domain


    LMCD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMCD1_HUMAN, Q9NZU5
    Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in
    repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans
    activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
    promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of
    calcineurin/nuclear factor of activated T-cells signaling pathway

         Genatlas biochemistry entry for LMCD1:
    LIM and cysteine-rich domains 1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    LMCD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMCD1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMCD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LMCD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMCD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMCD1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMCD1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate LMCD1:
    hsa-miR-499-5p hsa-miR-96* hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidLMCD1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: LMCD1 (NM_014583)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMCD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LMCD1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for LMCD1 (Q9NZU52, 3 ENSP000001576004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503680 I2D: score=1 STRING: ENSP00000363390
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6504050 I2D: score=1 STRING: ENSP00000262435
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    AXIN2Q9Y2T13I2D: score=1 
    PRKAG3ENSP000002339444STRING: ENSP00000233944
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0010611regulation of cardiac muscle hypertrophy IMP--
    GO:0070886positive regulation of calcineurin-NFAT signaling cascade IMP--

    LMCD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LMCD1

    Search CenterWatch for drugs/clinical trials and news about LMCD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LMCD1 gene (4 alternative transcripts): 
    NM_001278233.1  NM_001278234.1  NM_001278235.1  NM_014583.3  

    Unigene Cluster for LMCD1:

    LIM and cysteine-rich domains 1
    Hs.475353  [show with all ESTs]
    Unigene Representative Sequence: AK074448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000157600(uc003bqq.3 uc011atd.2 uc011ate.2) ENST00000415597
    ENST00000470776 ENST00000454244 ENST00000456506 ENST00000426878(uc011atf.1)
    ENST00000535732 ENST00000397386
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate LMCD1:
    hsa-miR-499-5p hsa-miR-96* hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidLMCD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMCD1
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    GenScript: all cDNA clones in your preferred vector: LMCD1 (NM_014583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMCD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMCD1
    Sirion Biotech Customized lentivirus for stable overexpression of LMCD1 
                         Customized lentivirus expression plasmids for stable overexpression of LMCD1 
    Primer
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    OriGene qPCR primer pairs and template standards for LMCD1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LMCD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMCD1

    Additional mRNA sequence: 

    AF169284.1 AF216709.1 AK022176.1 AK074448.1 AK293849.1 AK294455.1 AK300803.1 BC000646.2 

    6 DOTS entries:

    DT.452062  DT.215460  DT.424987  DT.75160787  DT.91729118  DT.100000735 

    24/187 AceView cDNA sequences (see all 187):

    AI352072 AI148098 BP372862 AI494112 CA441311 AI751818 BM852592 AI494078 
    BQ940283 BU737430 BG031300 BP338305 AI888544 H13867 AI307177 BM921611 
    BP340946 BM790038 AI344126 AI936538 BP334926 BU619403 BP374311 BF436314 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LMCD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                       -                 -               
    SP2:                                                                              
    SP3:                    -                                                         
    SP4:                    -     -                 -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for LMCD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMCD1 expression in normal human tissues (normalized intensities)      LMCD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAAAAAA
    LMCD1 Expression
    About this image


    LMCD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Zeugopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             skeletal muscle ; myocytes   
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Human Astrocytes   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor E68

    See LMCD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMCD1

    SOURCE GeneReport for Unigene cluster: Hs.475353

    UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
    Tissue specificity: Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in
    skeletal muscle

        SABiosciences Custom PCR Arrays for LMCD1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMCD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMCD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMCD1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmcd11 , 5 LIM and cysteine-rich domains 11, 5 87.31(n)1
    92.88(a)1
      6 (52.14 cM)5
    309371  NM_144799.21  NP_659048.11 
     1122737585 
    chicken
    (Gallus gallus)
    Aves LMCD11 LIM and cysteine-rich domains 1 73.28(n)
    72.35(a)
      416113  XM_414443.3  XP_414443.2 
    lizard
    (Anolis carolinensis)
    Reptilia LMCD16
    LIM and cysteine-rich domains 1
    68(a)
    1 ↔ 1
    GL343412.1(278586-354476)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565332 similar to testis derived transcript 72.49(n)   394045  BC049043.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tes6
    Testin ortholog
    12(a)
    1 → many
    2R(13353384-13356681)
    worm
    (Caenorhabditis elegans)
    Secernentea tes-16
    Protein TES-1
    20(a)
    1 → many
    IV(7449084-7451445)


    ENSEMBL Gene Tree for LMCD1 (if available)
    TreeFam Gene Tree for LMCD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMCD1 gene
    PRICKLE32  PRICKLE42  TES2  PRICKLE22  PRICKLE12  
    5 SIMAP similar genes for LMCD1 using alignment to 7 protein entries:     LMCD1_HUMAN (see all proteins):
    DKFZp586B2022    TES    RILP    PRICKLE1    LIMS2

    LMCD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1415 SNPs in LMCD1 are shown (see all 1415)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159986161,2
    F--8545381(+) GGCTTC/GATTTT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs170492141,2
    C,F,H--8545478(+) GGTGGC/AAGAGT 1 -- int124Minor allele frequency- A:0.05NA NS EA WA 2810
    rs762130401,2
    C,F--8545529(+) TAATAT/CAAGCT 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1392192781,2
    C--8545687(+) TCTCCC/TTCTTG 1 -- int10--------
    rs1866891261,2
    --8545767(+) AGAGAA/GAGAAT 1 -- int10--------
    rs93120221,2
    C,F,H--8545800(+) CAGATT/ATTTTT 1 -- int19Minor allele frequency- A:0.26NS EA NA WA 664
    rs769303081,2
    F--8545890(+) GGGAGG/AGAGGA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs731279221,2
    C,F--8545901(+) GAGCCG/CAGAAG 1 -- int12Minor allele frequency- C:0.03WA 120
    rs1181723611,2
    C,F--8545941(+) GTGATT/GAAGTA 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1915530131,2
    --8545951(+) ACTACA/GTGATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for LMCD1 (8543393 - 8609806 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LMCD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724875CNV Deletion23290073
    nsv820839CNV Duplication20802225
    esv1238714CNV Insertion17803354
    nsv821979CNV Loss20364138
    nsv519789CNV Loss19592680
    nsv821980CNV Loss20364138
    esv259668OTHER Complex20981092
    esv259915OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604859    OMIM disorders: --

    2 diseases for LMCD1:    About MalaCards
    hepatocellular carcinoma    


    LMCD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LMCD1
    Human Genome Epidemiology (HuGE) Navigator: LMCD1 (1 document)

    Export disorders for LMCD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMCD1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with LMCD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse. (PubMed id 10662546)1, 2, 3 Bespalova I.N. and Burmeister M. (2000)
    2. LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. (PubMed id 16199866)1, 2, 9 Rath N.... Morrisey E.E. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Somatic LMCD1 mutations promoted cell migration and tu mor metastasis in hepatocellular carcinoma. (PubMed id 21996735)1 Chang C.Y....Jou Y.S. (2012)
    7. Sphingosine 1-phosphate induces differentiation of me soangioblasts towards smooth muscle. A role for GATA6. (PubMed id 21629665)1 Donati C....Bruni P. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling. (PubMed id 20026769)2 Bian Z.Y.... Li H. (2010)
    10. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29995 HGNC: 6633 AceView: LMCD1 Ensembl:ENSG00000071282 euGenes: HUgn29995
    ECgene: LMCD1 H-InvDB: LMCD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMCD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMCD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LMCD1 gene:
    Search GeneIP for patents involving LMCD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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