Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LMCD1 Gene

protein-coding   GIFtS: 56
GCID: GC03P008518

LIM And Cysteine-Rich Domains 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LIM And Cysteine-Rich Domains 11 2
dyxin1 2
LIM And Cysteine-Rich Domains Protein 12
Dyxin3

External Ids:    HGNC: 66331   Entrez Gene: 299952   Ensembl: ENSG000000712827   OMIM: 6048595   UniProtKB: Q9NZU53   

Export aliases for LMCD1 gene to outside databases

Previous GC identifer: GC03P008472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LMCD1 Gene:
This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an
N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement
in protein-protein interactions. The protein may act as a co-regulator of transcription along with other
transcription factors. Alternate splicing results in multiple transcript variants of this gene. (provided by
RefSeq, May 2013)

GeneCards Summary for LMCD1 Gene:
LMCD1 (LIM and cysteine-rich domains 1) is a protein-coding gene. Diseases associated with LMCD1 include sinusitis, and hepatocellular carcinoma. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is PRICKLE3.

UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in
repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans
activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of
calcineurin/nuclear factor of activated T-cells signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the LMCD1 gene promoter:
         STAT1   p53   Bach2   AREB6   CREB   PPAR-gamma1   Nkx6-1   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMCD1 promoter sequence
   Search Chromatin IP Primers for LMCD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMCD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26-p24   Ensembl cytogenetic band:  3p26.1   HGNC cytogenetic band: 3p26-p24

LMCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMCD1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P008518:  view genomic region     (about GC identifiers)

Start:
8,543,393 bp from pter      End:
8,609,806 bp from pter
Size:
66,414 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5 (See protein sequence)
Recommended Name: LIM and cysteine-rich domains protein 1  
Size: 365 amino acids; 40833 Da
Subunit: Interacts with GATA1 and GATA4 (By similarity). Interacts with beta-dystroglycan. Interacts with GATA6
Secondary accessions: B4DG80
Alternative splicing: 2 isoforms:  Q9NZU5-1   Q9NZU5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LMCD1: NX_Q9NZU5

Explore proteomics data for LMCD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LMCD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265162.1  NP_001265163.1  NP_001265164.1  NP_055398.1  

    ENSEMBL proteins: 
     ENSP00000157600   ENSP00000400555   ENSP00000396515   ENSP00000405049   ENSP00000411222  
     ENSP00000441100   ENSP00000380542  

    LMCD1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LMCD1
    OriGene Protein Over-expression Lysate for LMCD1
    OriGene MassSpec for LMCD1
    OriGene Custom Protein Services for LMCD1
    GenScript Custom Purified and Recombinant Proteins Services for LMCD1
    Novus Biologicals LMCD1 Proteins
    Novus Biologicals LMCD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LMCD1

    LMCD1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LMCD1
    OriGene Custom Antibody Services for LMCD1
    Novus Biologicals LMCD1 Antibodies
    Abcam antibodies for LMCD1
    Cloud-Clone Corp. Antibodies for LMCD1
    ThermoFisher Antibodies for LMCD1
    LSBio Antibodies in human, mouse, rat for LMCD1

    LMCD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LMCD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LMCD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LMCD1
    Cloud-Clone Corp. CLIAs for LMCD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR010442 PET_domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q9NZU5

    ProtoNet protein and cluster: Q9NZU5

    2 Blocks protein domains:
    IPB001781 Zn-binding protein
    IPB010442 PET


    UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
    Domain: The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6 (By similarity)
    Similarity: Contains 2 LIM zinc-binding domains
    Similarity: Contains 1 PET domain


    LMCD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMCD1_HUMAN, Q9NZU5
    Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in
    repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans
    activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC
    promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of
    calcineurin/nuclear factor of activated T-cells signaling pathway

         Genatlas biochemistry entry for LMCD1:
    LIM and cysteine-rich domains 1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    LMCD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMCD1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMCD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMCD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMCD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMCD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LMCD1:
    hsa-mir-26b-5p (MIRT029419), hsa-mir-335-5p (MIRT017807), hsa-mir-181b-5p (MIRT047240), hsa-mir-193b-3p (MIRT016355), hsa-mir-421 (MIRT039353)

    Block miRNA regulation of human, mouse, rat LMCD1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LMCD1:
    hsa-miR-499-5p hsa-miR-96* hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidLMCD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LMCD1
    Predesigned siRNA for gene silencing in human, mouse, rat LMCD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LMCD1

    Clone
    Products:
         
    OriGene clones in human, mouse for LMCD1 (see all 6)
    OriGene ORF clones in mouse, rat for LMCD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMCD1 (NM_014583)
    Sino Biological Human cDNA Clone for LMCD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMCD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMCD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LMCD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LMCD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMCD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LMCD1_HUMAN, Q9NZU5: Cytoplasm (By similarity). Nucleus (By similarity). Note=May shuttle between the cytoplasm
    and the nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol3
    nucleus3
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0031012colocalizes with extracellular matrix IDA--

    LMCD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LMCD1
    Interactions:

        Search GeneGlobe Interaction Network for LMCD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for LMCD1 (Q9NZU52, 3 ENSP000001576004) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503680 I2D: score=1 STRING: ENSP00000363390
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6504050 I2D: score=1 STRING: ENSP00000262435
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    AXIN2Q9Y2T13I2D: score=1 
    PRKAG3ENSP000002339444STRING: ENSP00000233944
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0010611regulation of cardiac muscle hypertrophy IMP--
    GO:0070886positive regulation of calcineurin-NFAT signaling cascade IMP--

    LMCD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LMCD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LMCD1 gene (4 alternative transcripts): 
    NM_001278233.1  NM_001278234.1  NM_001278235.1  NM_014583.3  

    Unigene Cluster for LMCD1:

    LIM and cysteine-rich domains 1
    Hs.475353  [show with all ESTs]
    Unigene Representative Sequence: AK074448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000157600(uc003bqq.3 uc011atd.2 uc011ate.2) ENST00000415597
    ENST00000470776 ENST00000454244 ENST00000456506 ENST00000426878(uc011atf.1)
    ENST00000535732 ENST00000397386
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LMCD1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LMCD1:
    hsa-miR-499-5p hsa-miR-96* hsa-miR-765
    SwitchGear 3'UTR luciferase reporter plasmidLMCD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LMCD1
    Predesigned siRNA for gene silencing in human, mouse, rat LMCD1
    Clone
    Products:
         
    OriGene clones in human, mouse for LMCD1 (see all 6)
    OriGene ORF clones in mouse, rat for LMCD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LMCD1 (NM_014583)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMCD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMCD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LMCD1
    OriGene qSTAR qPCR primer pairs in human, mouse for LMCD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMCD1
      QuantiTect SYBR Green Assays in human, mouse, rat LMCD1
      QuantiFast Probe-based Assays in human, mouse, rat LMCD1

    Additional mRNA sequence: 

    AF169284.1 AF216709.1 AK022176.1 AK074448.1 AK293849.1 AK294455.1 AK300803.1 BC000646.2 

    6 DOTS entries:

    DT.452062  DT.215460  DT.424987  DT.75160787  DT.91729118  DT.100000735 

    Selected AceView cDNA sequences (see all 187):

    BF436678 AI344126 W67441 AI751818 NM_014583 CA441311 BU619403 BM314415 
    BP334926 BQ940283 CA849076 AI494078 H28693 BP374311 BP338305 BP338699 
    BG031300 AI273430 AI936538 H13867 AI074233 BM921611 BP372862 BU737430 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LMCD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                    -                       -                 -               
    SP2:                                                                              
    SP3:                    -                                                         
    SP4:                    -     -                 -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for LMCD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LMCD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAAAAAAA
    LMCD1 Expression
    About this image


    LMCD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Zeugopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    LMCD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LMCD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475353

    UniProtKB/Swiss-Prot: LMCD1_HUMAN, Q9NZU5
    Tissue specificity: Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in
    skeletal muscle

        Custom PCR Arrays for LMCD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LMCD1
    OriGene qSTAR qPCR primer pairs in human, mouse for LMCD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMCD1
    QuantiTect SYBR Green Assays in human, mouse, rat LMCD1
    QuantiFast Probe-based Assays in human, mouse, rat LMCD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMCD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LMCD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmcd11 , 5 LIM and cysteine-rich domains 11, 5 87.31(n)1
    92.88(a)1
      6 (52.14 cM)5
    309371  NM_144799.21  NP_659048.11 
     1122737585 
    chicken
    (Gallus gallus)
    Aves LMCD11 LIM and cysteine-rich domains 1 73.28(n)
    72.35(a)
      416113  XM_414443.4  XP_414443.2 
    lizard
    (Anolis carolinensis)
    Reptilia LMCD16
    LIM and cysteine-rich domains 1
    68(a)
    1 ↔ 1
    GL343412.1(278586-354476)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565332 similar to testis derived transcript 72.49(n)   394045  BC049043.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tes6
    Testin ortholog
    13(a)
    1 → many
    2R(13353384-13356681)
    worm
    (Caenorhabditis elegans)
    Secernentea tes-16
    Protein TES-1 (tes-1) mRNA, complete cds
    22(a)
    1 → many
    IV(7449084-7451445) WBGene00015217


    ENSEMBL Gene Tree for LMCD1 (if available)
    TreeFam Gene Tree for LMCD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LMCD1 gene
    PRICKLE32  PRICKLE42  TES2  PRICKLE22  PRICKLE12  
    5 SIMAP similar genes for LMCD1 using alignment to 6 protein entries:     LMCD1_HUMAN (see all proteins):
    DKFZp586B2022    TES    RILP    PRICKLE1    LIMS2

    LMCD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LMCD1 (see all 1415)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159986161,2
    F--8545381(+) GGCTTC/GATTTT 1 -- int11Minor allele frequency- G:0.02NA 120
    rs170492141,2
    C,F,H--8545478(+) GGTGGC/AAGAGT 1 -- int124Minor allele frequency- A:0.05NA NS EA WA 2810
    rs762130401,2
    C,F--8545529(+) TAATAT/CAAGCT 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1392192781,2
    C--8545687(+) TCTCCC/TTCTTG 1 -- int10--------
    rs1866891261,2
    --8545767(+) AGAGAA/GAGAAT 1 -- int10--------
    rs93120221,2
    C,F,H--8545800(+) CAGATT/ATTTTT 1 -- int19Minor allele frequency- A:0.26NS EA NA WA 664
    rs769303081,2
    F--8545890(+) GGGAGG/AGAGGA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs731279221,2
    C,F--8545901(+) GAGCCG/CAGAAG 1 -- int12Minor allele frequency- C:0.03WA 120
    rs1181723611,2
    C,F--8545941(+) GTGATT/GAAGTA 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1915530131,2
    --8545951(+) ACTACA/GTGATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for LMCD1 (8543393 - 8609806 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LMCD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724875CNV Deletion23290073
    nsv820839CNV Duplication20802225
    esv1238714CNV Insertion17803354
    nsv821979CNV Loss20364138
    nsv519789CNV Loss19592680
    nsv821980CNV Loss20364138
    esv259668OTHER Complex20981092
    esv259915OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LMCD1
    DNA2.0 Custom Variant and Variant Library Synthesis for LMCD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604859    OMIM disorders: --

    4 diseases for LMCD1:    
    About MalaCards
    sinusitis    hepatocellular carcinoma    cerebritis    endotheliitis


    LMCD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LMCD1
    Human Genome Epidemiology (HuGE) Navigator: LMCD1 (1 document)

    Export disorders for LMCD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LMCD1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with LMCD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse. (PubMed id 10662546)1, 2, 3 Bespalova I.N. and Burmeister M. (Genomics 2000)
    2. LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. (PubMed id 16199866)1, 2, 9 Rath N.... Morrisey E.E. (Mol. Cell. Biol. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    7. Somatic LMCD1 mutations promoted cell migration and tumor metastasis in hepatocellular carcinoma. (PubMed id 21996735)1 Chang C.Y....Jou Y.S. (Oncogene 2012)
    8. Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6. (PubMed id 21629665)1 Donati C....Bruni P. (PLoS ONE 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling. (PubMed id 20026769)2 Bian Z.Y.... Li H. (Hypertension 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29995 HGNC: 6633 AceView: LMCD1 Ensembl:ENSG00000071282 euGenes: HUgn29995
    ECgene: LMCD1 H-InvDB: LMCD1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LMCD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LMCD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LMCD1 gene:
    Search GeneIP for patents involving LMCD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LMCD1   OriGene RNAi products in human, mouse, rat for LMCD1  
     OriGene qPCR primer pairs and template standards for LMCD1   OriGene Protein Over-expression Lysate for LMCD1  
     OriGene MassSpec something-or-other for LMCD1   OriGene clones in human, mouse for LMCD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LMCD1   OriGene Purified Protein for LMCD1  
     OriGene ORF clones in mouse, rat for LMCD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LMCD1   OriGene Custom Protein Services for LMCD1  

     
     
     Block miRNA regulation of human, mouse, rat LMCD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LMCD1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMCD1 Predesigned siRNA for gene silencing in human, mouse, rat LMCD1
     QuantiFast Probe-based Assays in human, mouse, rat LMCD1 QuantiTect SYBR Green Assays in human, mouse, rat LMCD1
     Custom PCR Arrays for LMCD1 Search Chromatin IP Primers for LMCD1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMCD1  Search GeneGlobe Interaction Network for LMCD1
     Regulatory tfbs in LMCD1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LMCD1 GenScript cDNA clones with any tag delivered in your preferred vector for LMCD1
     GenScript Custom Assay Services for LMCD1 GenScript Custom overexpressing Cell Line Services for LMCD1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LMCD1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for LMCD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LMCD1 antibodies
     LMCD1 proteins
     LMCD1 lysates
     Antibodies for LMCD1
     See all of Abcam's Antibodies, Kits and Proteins for LMCD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LMCD1
     Antibodies for LMCD1
     ELISAs for LMCD1
     CLIAs for LMCD1



     Browse ESI BIO Cell Lines and PureStem Progenitors for LMCD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMCD1
     SwitchGear 3'UTR luciferase reporter plasmids for LMCD1
     SwitchGear Promoter luciferase reporter plasmids for LMCD1
     ThermoFisher Antibodies for LMCD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMCD1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMCD1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMCD1
     LSBio Antibodies in human, mouse, rat for LMCD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LMCD1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4