Aliases for LMAN2 Gene
External Ids for LMAN2 Gene
Previous HGNC Symbols for LMAN2 Gene
Previous GeneCards Identifiers for LMAN2 Gene
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]
GeneCards Summary for LMAN2 Gene
LMAN2 (Lectin, Mannose Binding 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include carbohydrate binding and heat shock protein binding. An important paralog of this gene is LMAN2L.
UniProtKB/Swiss-Prot for LMAN2 Gene
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).