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Aliases for LMAN2 Gene

Aliases for LMAN2 Gene

  • Lectin, Mannose-Binding 2 2 3
  • Vesicular Integral-Membrane Protein 36 3 4
  • Glycoprotein GP36b 3 4
  • C5orf8 3 4
  • VIP36 3 4
  • Vesicular Integral Protein Of 36 KDa 3
  • Chromosome 5 Open Reading Frame 8 2
  • Lectin Mannose-Binding 2 4
  • GP36B 3

External Ids for LMAN2 Gene

Previous HGNC Symbols for LMAN2 Gene

  • C5orf8

Previous GeneCards Identifiers for LMAN2 Gene

  • GC05M176694
  • GC05M176739
  • GC05M176691
  • GC05M176758
  • GC05M171681

Summaries for LMAN2 Gene

Entrez Gene Summary for LMAN2 Gene

  • This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

GeneCards Summary for LMAN2 Gene

LMAN2 (Lectin, Mannose-Binding 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include carbohydrate binding and heat shock protein binding. An important paralog of this gene is LMAN2L.

UniProtKB/Swiss-Prot for LMAN2 Gene

  • Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).

Gene Wiki entry for LMAN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMAN2 Gene

Genomics for LMAN2 Gene

Regulatory Elements for LMAN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LMAN2 Gene

Chromosome:
5
Start:
177,331,562 bp from pter
End:
177,351,884 bp from pter
Size:
20,323 bases
Orientation:
Minus strand

Genomic View for LMAN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMAN2 Gene

Proteins for LMAN2 Gene

  • Protein details for LMAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12907-LMAN2_HUMAN
    Recommended name:
    Vesicular integral-membrane protein VIP36
    Protein Accession:
    Q12907
    Secondary Accessions:
    • Q53HH1

    Protein attributes for LMAN2 Gene

    Size:
    356 amino acids
    Molecular mass:
    40229 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for LMAN2 Gene

Proteomics data for LMAN2 Gene at MOPED

Post-translational modifications for LMAN2 Gene

  • Ubiquitination at Lys 126, Lys 300, and Lys 303
  • Glycosylation at Asn 183
  • Modification sites at PhosphoSitePlus

Other Protein References for LMAN2 Gene

Antibody Products

No data available for DME Specific Peptides for LMAN2 Gene

Domains & Families for LMAN2 Gene

Protein Domains for LMAN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LMAN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q12907

UniProtKB/Swiss-Prot:

LMAN2_HUMAN :
  • Contains 1 L-type lectin-like domain.
Domain:
  • Contains 1 L-type lectin-like domain.
genes like me logo Genes that share domains with LMAN2: view

No data available for Gene Families for LMAN2 Gene

Function for LMAN2 Gene

Molecular function for LMAN2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).

Gene Ontology (GO) - Molecular Function for LMAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 20477988
GO:0005537 mannose binding IMP 20477988
GO:0030246 carbohydrate binding IDA 23701871
GO:0031072 heat shock protein binding IPI 20477988
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LMAN2: view
genes like me logo Genes that share phenotypes with LMAN2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LMAN2 Gene

Localization for LMAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMAN2 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMAN2 Gene COMPARTMENTS Subcellular localization image for LMAN2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 5
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for LMAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space IDA 22016386
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IDA 20477988
genes like me logo Genes that share ontologies with LMAN2: view

Pathways & Interactions for LMAN2 Gene

genes like me logo Genes that share pathways with LMAN2: view

Interacting Proteins for LMAN2 Gene

Gene Ontology (GO) - Biological Process for LMAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 20477988
GO:0015031 protein transport IEA --
GO:0050766 positive regulation of phagocytosis IMP 22016386
genes like me logo Genes that share ontologies with LMAN2: view

No data available for SIGNOR curated interactions for LMAN2 Gene

Drugs & Compounds for LMAN2 Gene

(1) Drugs for LMAN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0

(2) Additional Compounds for LMAN2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
mannose
polysaccharide
genes like me logo Genes that share compounds with LMAN2: view

Transcripts for LMAN2 Gene

Unigene Clusters for LMAN2 Gene

Lectin, mannose-binding 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMAN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMAN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3:
SP4: - - - - - -
SP5: -
SP6: -

Relevant External Links for LMAN2 Gene

GeneLoc Exon Structure for
LMAN2
ECgene alternative splicing isoforms for
LMAN2

Expression for LMAN2 Gene

mRNA expression in normal human tissues for LMAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LMAN2 Gene

This gene is overexpressed in Urine (21.0) and Nasal epithelium (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMAN2 Gene



SOURCE GeneReport for Unigene cluster for LMAN2 Gene Hs.75864

mRNA Expression by UniProt/SwissProt for LMAN2 Gene

Q12907-LMAN2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with LMAN2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for LMAN2 Gene

Orthologs for LMAN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMAN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMAN2 35
  • 91.95 (n)
  • 95.17 (a)
LMAN2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMAN2 35
  • 90.73 (n)
  • 98.03 (a)
LMAN2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lman2 35
  • 88.58 (n)
  • 94.94 (a)
Lman2 16
Lman2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMAN2 35
  • 99.63 (n)
  • 99.72 (a)
LMAN2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lman2 35
  • 88.86 (n)
  • 94.1 (a)
oppossum
(Monodelphis domestica)
Mammalia LMAN2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMAN2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMAN2 35
  • 80.09 (n)
  • 87.22 (a)
LMAN2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMAN2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lman2 35
  • 72.17 (n)
  • 84.76 (a)
Str.5932 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22835 35
zebrafish
(Danio rerio)
Actinopterygii lman2 35
  • 71.2 (n)
  • 77.85 (a)
wufb16f04 35
lman2 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5510 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ile-2 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8400 36
  • 47 (a)
OneToMany
Species with no ortholog for LMAN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMAN2 Gene

ENSEMBL:
Gene Tree for LMAN2 (if available)
TreeFam:
Gene Tree for LMAN2 (if available)

Paralogs for LMAN2 Gene

Paralogs for LMAN2 Gene

(2) SIMAP similar genes for LMAN2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LMAN2: view

Variants for LMAN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for LMAN2 Gene

Variant ID Type Subtype PubMed ID
dgv1878e1 CNV Complex 17122850
nsv428132 CNV Gain 18775914
dgv6379n71 CNV Loss 21882294
nsv509103 CNV Insertion 20534489
nsv471057 CNV Loss 18288195
nsv819674 CNV Loss 19587683

Variation tolerance for LMAN2 Gene

Residual Variation Intolerance Score: 17.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMAN2 Gene

HapMap Linkage Disequilibrium report
LMAN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LMAN2 Gene

Disorders for LMAN2 Gene

Relevant External Links for LMAN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMAN2
genes like me logo Genes that share disorders with LMAN2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMAN2 Gene

Publications for LMAN2 Gene

  1. Profile-based data base scanning for animal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein. (PMID: 12609988) Nufer O. … Hauri H.-P. (J. Biol. Chem. 2003) 2 23 67
  2. Role of N-glycosylation in trafficking of apical membrane proteins in epithelia. (PMID: 18971212) Vagin O. … Sachs G. (Am. J. Physiol. Renal Physiol. 2009) 23 67
  3. Chemical approaches toward understanding glycan-mediated protein quality control. (PMID: 19822453) Takeda Y. … Ito Y. (Curr Opin Chem Biol 2009) 23 67
  4. Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36. (PMID: 18025080) Kamiya Y. … Kato K. (J. Biol. Chem. 2008) 23 67
  5. Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP. (PMID: 17586539) Nawa D. … Yamamoto K. (Glycobiology 2007) 23 67

Products for LMAN2 Gene

Sources for LMAN2 Gene

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