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Aliases for LMAN1L Gene

Aliases for LMAN1L Gene

  • Lectin, Mannose Binding 1 Like 2 3 5
  • ERGIC53-Like Protein 3 4
  • LMAN1-Like Protein 3 4
  • ERGL 3 4
  • Lectin, Mannose-Binding, 1 Like 2
  • Lectin Mannose-Binding 1-Like 4
  • ERGIC-53-Like Protein 3
  • Protein ERGIC-53-Like 3
  • ERGIC-53L 3

External Ids for LMAN1L Gene

Previous GeneCards Identifiers for LMAN1L Gene

  • GC15P068855
  • GC15M068223
  • GC15P072681
  • GC15P072821
  • GC15P072892
  • GC15P075105
  • GC15P051902

Summaries for LMAN1L Gene

GeneCards Summary for LMAN1L Gene

LMAN1L (Lectin, Mannose Binding 1 Like) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LMAN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMAN1L Gene

Genomics for LMAN1L Gene

Regulatory Elements for LMAN1L Gene

Enhancers for LMAN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074775 1.8 FANTOM5 Ensembl ENCODE 15.6 -24.5 -24515 26.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ULK3 ENSG00000260274 EDC3 C15orf39 CSK RPP25 CPLX3 LMAN1L DNM1P35 CYP1A1
GH15F074768 1.2 Ensembl ENCODE 11.8 -43.8 -43788 0.7 ATF1 PKNOX1 ZFP64 GLIS2 ZNF143 REST TBX21 ZNF518A ZNF623 ZNF264 ENSG00000260274 EDC3 ENSG00000203392 DNM1P35 UBL7-AS1 LOC101929333 SNX33 ISLR LMAN1L CYP1A1
GH15F074762 1 Ensembl ENCODE 10.9 -50.0 -49979 1.5 SOX13 PKNOX1 TAL1 ZNF133 ZNF140 MAX ZNF664 ZFHX2 GLIS2 NCOR1 EDC3 RPP25 ENSG00000260274 CYP1A1 ULK3 DNM1P35 CPLX3 LMAN1L CLK3 FAM219B
GH15F074759 1 ENCODE 10.9 -52.4 -52412 0.9 PKNOX1 ATF1 ARID4B ETS1 ZNF143 KDM4B SP5 GTF2B NFYC PPARG ULK3 LOC101929333 RPP25 EDC3 CYP1A1 MPI CSK CPLX3 LMAN1L CLK3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMAN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for LMAN1L Gene

74,812,716 bp from pter
74,825,758 bp from pter
13,043 bases
Plus strand

Genomic View for LMAN1L Gene

Genes around LMAN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMAN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMAN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMAN1L Gene

Proteins for LMAN1L Gene

  • Protein details for LMAN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ERGIC-53-like
    Protein Accession:
    Secondary Accessions:
    • Q6UWN2

    Protein attributes for LMAN1L Gene

    526 amino acids
    Molecular mass:
    57129 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMAN1L Gene


neXtProt entry for LMAN1L Gene

Post-translational modifications for LMAN1L Gene

  • Glycosylation at Asn 75
  • Modification sites at PhosphoSitePlus

Other Protein References for LMAN1L Gene

No data available for DME Specific Peptides for LMAN1L Gene

Domains & Families for LMAN1L Gene

Protein Domains for LMAN1L Gene

Suggested Antigen Peptide Sequences for LMAN1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 L-type lectin-like domain.
  • Contains 1 L-type lectin-like domain.
genes like me logo Genes that share domains with LMAN1L: view

No data available for Gene Families for LMAN1L Gene

Function for LMAN1L Gene

Gene Ontology (GO) - Molecular Function for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005537 mannose binding IBA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LMAN1L: view
genes like me logo Genes that share phenotypes with LMAN1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMAN1L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMAN1L Gene

Localization for LMAN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMAN1L Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMAN1L gene
Compartment Confidence
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMAN1L: view

Pathways & Interactions for LMAN1L Gene

genes like me logo Genes that share pathways with LMAN1L: view

Interacting Proteins for LMAN1L Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
Selected Interacting proteins: Q9HAT1-LMA1L_HUMAN ENSP00000310431 for LMAN1L Gene via IID STRING

Gene Ontology (GO) - Biological Process for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0007029 endoplasmic reticulum organization IBA --
GO:0007030 Golgi organization IBA --
genes like me logo Genes that share ontologies with LMAN1L: view

No data available for SIGNOR curated interactions for LMAN1L Gene

Transcripts for LMAN1L Gene

Unigene Clusters for LMAN1L Gene

Lectin, mannose-binding, 1 like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMAN1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP5: - -
SP6: -

ExUns: 19 ^ 20

Relevant External Links for LMAN1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMAN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMAN1L Gene

mRNA differential expression in normal tissues according to GTEx for LMAN1L Gene

This gene is overexpressed in Prostate (x14.1), Spleen (x10.8), Heart - Atrial Appendage (x10.7), Brain - Cerebellum (x6.1), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for LMAN1L Gene

This gene is overexpressed in Pancreas (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMAN1L Gene

Protein tissue co-expression partners for LMAN1L Gene

NURSA nuclear receptor signaling pathways regulating expression of LMAN1L Gene:


SOURCE GeneReport for Unigene cluster for LMAN1L Gene:


mRNA Expression by UniProt/SwissProt for LMAN1L Gene:

Tissue specificity: Highly expressed in normal and neoplastic prostate. Also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS.
genes like me logo Genes that share expression patterns with LMAN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LMAN1L Gene

Orthologs for LMAN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for LMAN1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LMAN1L 34 35
  • 98.23 (n)
(Bos Taurus)
Mammalia LMAN1L 34 35
  • 83.06 (n)
(Canis familiaris)
Mammalia LMAN1L 34 35
  • 82.34 (n)
(Mus musculus)
Mammalia Lman1l 34 16 35
  • 79.22 (n)
(Rattus norvegicus)
Mammalia Lman1l 34
  • 78.09 (n)
(Ornithorhynchus anatinus)
Mammalia LMAN1L 35
  • 56 (a)
(Monodelphis domestica)
Mammalia LMAN1L 35
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta ergic53 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea ile-1 35
  • 27 (a)
Species where no ortholog for LMAN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LMAN1L Gene

Gene Tree for LMAN1L (if available)
Gene Tree for LMAN1L (if available)

Paralogs for LMAN1L Gene

Paralogs for LMAN1L Gene

(2) SIMAP similar genes for LMAN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LMAN1L: view

Variants for LMAN1L Gene

Sequence variations from dbSNP and Humsavar for LMAN1L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193921107 Uncertain significance 74,824,365(+) GCCAA(G/T)GCCCC reference, missense
rs1060480 -- 74,825,575(+) AGGAG(G/T)CAGCC upstream-variant-2KB, reference, missense
rs11072509 -- 74,822,033(+) GGAGA(C/G)GTATT intron-variant
rs111601880 -- 74,819,173(+) GCCTC(A/C)CTCCC reference, missense
rs111702522 -- 74,823,749(+) TTCTT(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMAN1L Gene

Variant ID Type Subtype PubMed ID
nsv833055 CNV loss 17160897
nsv520527 CNV loss 19592680
nsv1121512 CNV deletion 24896259

Variation tolerance for LMAN1L Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.39; 85.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMAN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMAN1L Gene

Disorders for LMAN1L Gene

Relevant External Links for LMAN1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LMAN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMAN1L Gene

Publications for LMAN1L Gene

  1. ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. (PMID: 11255007) Yerushalmi N. … Pastan I. (Gene 2001) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 46 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis M.C. … Caporaso N.E. (PLoS Genet. 2011) 3 64

Products for LMAN1L Gene

Sources for LMAN1L Gene

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