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Aliases for LMAN1L Gene

Aliases for LMAN1L Gene

  • Lectin, Mannose Binding 1 Like 2 3 5
  • ERGIC53-Like Protein 3 4
  • LMAN1-Like Protein 3 4
  • ERGL 3 4
  • Lectin, Mannose-Binding, 1 Like 2
  • Lectin Mannose-Binding 1-Like 4
  • Protein ERGIC-53-Like 3
  • ERGIC-53L 3

External Ids for LMAN1L Gene

Previous GeneCards Identifiers for LMAN1L Gene

  • GC15P068855
  • GC15M068223
  • GC15P072681
  • GC15P072821
  • GC15P072892
  • GC15P075105
  • GC15P051902

Summaries for LMAN1L Gene

Entrez Gene Summary for LMAN1L Gene

  • This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]

GeneCards Summary for LMAN1L Gene

LMAN1L (Lectin, Mannose Binding 1 Like) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LMAN1.

Additional gene information for LMAN1L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMAN1L Gene

Genomics for LMAN1L Gene

Regulatory Elements for LMAN1L Gene

Enhancers for LMAN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H074775 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -24.5 -24543 25 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SIN3A EDC3 ENSG00000260274 LOC441728 ULK3 C15orf39 DNM1P35 ENSG00000203392 CSK RPP25
GH15H074768 1.2 Ensembl ENCODE 11.8 -43.7 -43715 0 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 REST ZNF518A ZNF292 ZNF610 GLIS1 MAN2C1 SIN3A ENSG00000260274 EDC3 ENSG00000203392 CLK3 PML DNM1P35 COMMD4 SNX33
GH15H074762 1.2 Ensembl ENCODE dbSUPER 10.9 -49.8 -49779 1 ZSCAN4 ZNF133 MAX ZNF398 ZNF664 ZFHX2 GLIS2 PATZ1 ZNF341 SP7 RPP25 EDC3 CYP1A1 ULK3 CPLX3 LMAN1L CLK3 FAM219B ENSG00000212279 PTPN9
GH15H074773 1 Ensembl ENCODE dbSUPER 11.4 -38.8 -38794 0 SOX13 CEBPA CEBPB CEBPG BCL6 CPLX3 LMAN1L COX5A FAM219B MPI SCAMP5 PTPN9 CSK CYP1A2
GH15H074759 1 ENCODE 10.9 -52.4 -52412 0 HNRNPUL1 PKNOX1 FOXA2 ATF1 ARNT ARID4B ETS1 ZNF143 SP5 GTF2B SIN3A CLK3 PML ENSG00000260274 LOC101929333 MAN2C1 ULK3 EDC3 RPP25 DNM1P34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LMAN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for LMAN1L Gene

Chromosome:
15
Start:
74,812,716 bp from pter
End:
74,825,758 bp from pter
Size:
13,043 bases
Orientation:
Plus strand

Genomic View for LMAN1L Gene

Genes around LMAN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMAN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMAN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMAN1L Gene

Proteins for LMAN1L Gene

  • Protein details for LMAN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT1-LMA1L_HUMAN
    Recommended name:
    Protein ERGIC-53-like
    Protein Accession:
    Q9HAT1
    Secondary Accessions:
    • Q6UWN2

    Protein attributes for LMAN1L Gene

    Size:
    526 amino acids
    Molecular mass:
    57129 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMAN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMAN1L Gene

Post-translational modifications for LMAN1L Gene

  • Glycosylation at posLast=7575
  • Modification sites at PhosphoSitePlus

Other Protein References for LMAN1L Gene

No data available for DME Specific Peptides for LMAN1L Gene

Domains & Families for LMAN1L Gene

Gene Families for LMAN1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LMAN1L Gene

Suggested Antigen Peptide Sequences for LMAN1L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LMAN1L: view

No data available for UniProtKB/Swiss-Prot for LMAN1L Gene

Function for LMAN1L Gene

Phenotypes From GWAS Catalog for LMAN1L Gene

Gene Ontology (GO) - Molecular Function for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with LMAN1L: view
genes like me logo Genes that share phenotypes with LMAN1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMAN1L

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LMAN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMAN1L Gene

Localization for LMAN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMAN1L Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LMAN1L gene
Compartment Confidence
extracellular 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with LMAN1L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LMAN1L Gene

Pathways & Interactions for LMAN1L Gene

genes like me logo Genes that share pathways with LMAN1L: view

Gene Ontology (GO) - Biological Process for LMAN1L Gene

None

No data available for SIGNOR curated interactions for LMAN1L Gene

Drugs & Compounds for LMAN1L Gene

No Compound Related Data Available

Transcripts for LMAN1L Gene

Unigene Clusters for LMAN1L Gene

Lectin, mannose-binding, 1 like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LMAN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LMAN1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: -
SP7:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LMAN1L Gene

GeneLoc Exon Structure for
LMAN1L
ECgene alternative splicing isoforms for
LMAN1L

Expression for LMAN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LMAN1L Gene

mRNA differential expression in normal tissues according to GTEx for LMAN1L Gene

This gene is overexpressed in Prostate (x14.1), Spleen (x10.8), Heart - Atrial Appendage (x10.7), Brain - Cerebellum (x6.1), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for LMAN1L Gene

This gene is overexpressed in Pancreas (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMAN1L Gene



Protein tissue co-expression partners for LMAN1L Gene

NURSA nuclear receptor signaling pathways regulating expression of LMAN1L Gene:

LMAN1L

SOURCE GeneReport for Unigene cluster for LMAN1L Gene:

Hs.620644

mRNA Expression by UniProt/SwissProt for LMAN1L Gene:

Q9HAT1-LMA1L_HUMAN
Tissue specificity: Highly expressed in normal and neoplastic prostate. Also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS.
genes like me logo Genes that share expression patterns with LMAN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LMAN1L Gene

Orthologs for LMAN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for LMAN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMAN1L 33 34
  • 98.23 (n)
cow
(Bos Taurus)
Mammalia LMAN1L 33 34
  • 83.06 (n)
dog
(Canis familiaris)
Mammalia LMAN1L 33 34
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Lman1l 33 16 34
  • 79.22 (n)
rat
(Rattus norvegicus)
Mammalia Lman1l 33
  • 78.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LMAN1L 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LMAN1L 34
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ergic53 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ile-1 34
  • 27 (a)
OneToMany
Species where no ortholog for LMAN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LMAN1L Gene

ENSEMBL:
Gene Tree for LMAN1L (if available)
TreeFam:
Gene Tree for LMAN1L (if available)

Paralogs for LMAN1L Gene

Paralogs for LMAN1L Gene

(2) SIMAP similar genes for LMAN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LMAN1L: view

Variants for LMAN1L Gene

Sequence variations from dbSNP and Humsavar for LMAN1L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs193921107 Uncertain significance 74,824,365(+) GCCAA(G/T)GCCCC reference, missense
rs1000012172 -- 74,821,966(+) AGAAC(C/T)AGGGC intron-variant
rs1000343289 -- 74,817,591(+) AGCCT(C/G)GTCAC intron-variant
rs1000418064 -- 74,824,090(+) ACTTC(-/TCTCT)TCTCT intron-variant
rs1000868907 -- 74,823,850(+) GTGCA(C/T)ACGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMAN1L Gene

Variant ID Type Subtype PubMed ID
nsv1121512 CNV deletion 24896259
nsv520527 CNV loss 19592680
nsv833055 CNV loss 17160897

Variation tolerance for LMAN1L Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.39; 85.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMAN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMAN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMAN1L Gene

Disorders for LMAN1L Gene

Relevant External Links for LMAN1L

Genetic Association Database (GAD)
LMAN1L
Human Genome Epidemiology (HuGE) Navigator
LMAN1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMAN1L

No disorders were found for LMAN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMAN1L Gene

Publications for LMAN1L Gene

  1. ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. (PMID: 11255007) Yerushalmi N … Pastan I (Gene 2001) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C … Munroe PB (Nature genetics 2009) 3 45 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis MC … Caporaso NE (PLoS genetics 2011) 3 60

Products for LMAN1L Gene

Sources for LMAN1L Gene

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