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Aliases for LMAN1L Gene

Aliases for LMAN1L Gene

  • Lectin, Mannose Binding 1 Like 2 3
  • Lectin, Mannose-Binding, 1 Like 2 3 5
  • Lectin Mannose-Binding 1-Like 3 4
  • ERGIC53-Like Protein 3 4
  • LMAN1-Like Protein 3 4
  • ERGL 3 4
  • ERGIC-53-Like Protein 3
  • ERGIC-53L 3

External Ids for LMAN1L Gene

Previous GeneCards Identifiers for LMAN1L Gene

  • GC15P068855
  • GC15M068223
  • GC15P072681
  • GC15P072821
  • GC15P072892
  • GC15P075105
  • GC15P051902

Summaries for LMAN1L Gene

GeneCards Summary for LMAN1L Gene

LMAN1L (Lectin, Mannose Binding 1 Like) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is LMAN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMAN1L Gene

Genomics for LMAN1L Gene

Regulatory Elements for LMAN1L Gene

Enhancers for LMAN1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LMAN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for LMAN1L Gene

Chromosome:
15
Start:
74,812,716 bp from pter
End:
74,825,758 bp from pter
Size:
13,043 bases
Orientation:
Plus strand

Genomic View for LMAN1L Gene

Genes around LMAN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMAN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMAN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMAN1L Gene

Proteins for LMAN1L Gene

  • Protein details for LMAN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT1-LMA1L_HUMAN
    Recommended name:
    Protein ERGIC-53-like
    Protein Accession:
    Q9HAT1
    Secondary Accessions:
    • Q6UWN2

    Protein attributes for LMAN1L Gene

    Size:
    526 amino acids
    Molecular mass:
    57129 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LMAN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMAN1L Gene

Proteomics data for LMAN1L Gene at MOPED

Post-translational modifications for LMAN1L Gene

  • Glycosylation at Asn 75
  • Modification sites at PhosphoSitePlus

Other Protein References for LMAN1L Gene

No data available for DME Specific Peptides for LMAN1L Gene

Domains & Families for LMAN1L Gene

Protein Domains for LMAN1L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LMAN1L Gene

Graphical View of Domain Structure for InterPro Entry

Q9HAT1

UniProtKB/Swiss-Prot:

LMA1L_HUMAN :
  • Contains 1 L-type lectin-like domain.
Domain:
  • Contains 1 L-type lectin-like domain.
genes like me logo Genes that share domains with LMAN1L: view

No data available for Gene Families for LMAN1L Gene

Function for LMAN1L Gene

genes like me logo Genes that share phenotypes with LMAN1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LMAN1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LMAN1L Gene

Localization for LMAN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMAN1L Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMAN1L Gene COMPARTMENTS Subcellular localization image for LMAN1L gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LMAN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with LMAN1L: view

Pathways & Interactions for LMAN1L Gene

genes like me logo Genes that share pathways with LMAN1L: view

Interacting Proteins for LMAN1L Gene

Gene Ontology (GO) - Biological Process for LMAN1L Gene

None

No data available for SIGNOR curated interactions for LMAN1L Gene

Drugs & Compounds for LMAN1L Gene

No Compound Related Data Available

Transcripts for LMAN1L Gene

Unigene Clusters for LMAN1L Gene

Lectin, mannose-binding, 1 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMAN1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: -
SP7:

ExUns: 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for LMAN1L Gene

GeneLoc Exon Structure for
LMAN1L
ECgene alternative splicing isoforms for
LMAN1L

Expression for LMAN1L Gene

mRNA expression in normal human tissues for LMAN1L Gene

mRNA differential expression in normal tissues according to GTEx for LMAN1L Gene

This gene is overexpressed in Prostate (x14.1), Spleen (x10.8), Heart - Atrial Appendage (x10.7), Brain - Cerebellum (x6.1), and Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for LMAN1L Gene

This gene is overexpressed in Pancreas (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LMAN1L Gene



SOURCE GeneReport for Unigene cluster for LMAN1L Gene Hs.620644

mRNA Expression by UniProt/SwissProt for LMAN1L Gene

Q9HAT1-LMA1L_HUMAN
Tissue specificity: Highly expressed in normal and neoplastic prostate. Also expressed in cardiac atrium, salivary gland, spleen and selective cells in the CNS.
genes like me logo Genes that share expression patterns with LMAN1L: view

Protein tissue co-expression partners for LMAN1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LMAN1L Gene

Orthologs for LMAN1L Gene

This gene was present in the common ancestor of animals.

Orthologs for LMAN1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMAN1L 35
  • 83.06 (n)
  • 74.07 (a)
LMAN1L 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMAN1L 35
  • 82.34 (n)
  • 74.04 (a)
LMAN1L 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lman1l 35
  • 79.22 (n)
  • 69.12 (a)
Lman1l 16
Lman1l 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMAN1L 35
  • 98.23 (n)
  • 96.96 (a)
LMAN1L 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lman1l 35
  • 78.09 (n)
  • 67.53 (a)
oppossum
(Monodelphis domestica)
Mammalia LMAN1L 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMAN1L 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ergic53 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ile-1 36
  • 27 (a)
OneToMany
Species with no ortholog for LMAN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LMAN1L Gene

ENSEMBL:
Gene Tree for LMAN1L (if available)
TreeFam:
Gene Tree for LMAN1L (if available)

Paralogs for LMAN1L Gene

Paralogs for LMAN1L Gene

(2) SIMAP similar genes for LMAN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LMAN1L: view

Variants for LMAN1L Gene

Sequence variations from dbSNP and Humsavar for LMAN1L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803568 - 74,816,295(-) CTCCC(C/T)GGCGC reference, missense
VAR_049772 -
rs7162232 -- 74,823,554(+) CCCCG(A/G)TTAGG intron-variant
rs12441444 -- 74,814,499(+) ctccc(A/G)agtag intron-variant
rs12441505 -- 74,814,970(+) CTGCT(A/C)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMAN1L Gene

Variant ID Type Subtype PubMed ID
nsv904380 CNV Loss 21882294
nsv833055 CNV Loss 17160897
nsv520527 CNV Loss 19592680
nsv904381 CNV Loss 21882294

Variation tolerance for LMAN1L Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.39; 85.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LMAN1L Gene

Disorders for LMAN1L Gene

Relevant External Links for LMAN1L

Genetic Association Database (GAD)
LMAN1L
Human Genome Epidemiology (HuGE) Navigator
LMAN1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMAN1L

No disorders were found for LMAN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMAN1L Gene

Publications for LMAN1L Gene

  1. ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. (PMID: 11255007) Yerushalmi N. … Pastan I. (Gene 2001) 2 3 4 23 67
  2. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. (PMID: 21490707) Cornelis M.C. … Caporaso N.E. (PLoS Genet. 2011) 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3

Products for LMAN1L Gene

Sources for LMAN1L Gene

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