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LMAN1 Gene

protein-coding GIFtS: 60

GC18M055148

lectin, mannose-binding, 1
(Previous name: coagulation factor V-factor VIII combined deficiency )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: F5F8D)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ERGIC-53 ^¹, ²
ERGIC53 ^¹, ², ³, ⁵
F5F8D ^², ³, ⁵
FMFD1 ^¹, ²
Gp58 ^³
MCFD1 ^¹, ², ⁵
MR60 ^¹, ²
gp58 ^¹, ²

Descriptions
ER-Golgi intermediate compartment 53 kDa protein ^³
Intracellular mannose-specific lectin MR60 ^³
Lectin mannose-binding 1 ^³
coagulation factor V-factor VIII combined deficiency ^¹
endoplasmic reticulum-golgi intermediate compartment protein 53 ^²
intracellular mannose specific lectin ^²
lectin, mannose-binding, 1 ^²

External Ids
HGNC: 6631¹
Entrez Gene: 3998²
UniProtKB: P49257³
Ensembl: ENSG00000074695⁷

Search outside databases for aliases for LMAN1 gene

Previous GC identifers: GC18M056829 GC18M056969 GC18M055146

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LMAN1:

The protein encoded by this gene is a type I integral membrane protein localized in the

intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between

the two compartments. The protein is a mannose-specific lectin and is a member of a novel family

of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are

associated with a coagulation defect. Using positional cloning, the gene was identified as the

disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive

disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq]

UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257

Function: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or

glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins,

lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi

transport of selected proteins

Gene Wiki entry for LMAN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LMAN1 gene

Entrez Gene cytogenetic band: 18q21.3-q22 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q21.3-q22

LMAN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M055148: (about GC identifiers)

Start:	55,148,088 bp from pter
End:	55,177,463 bp from pter
Size:	29,376 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257 (See protein sequence)

Recommended Name: Protein ERGIC-53 precursor

Size: 510 amino acids; 57549 Da

Subunit: Forms disulfide-linked dimers and hexamers. Interacts with MCFD2

Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass

type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic

reticulum membrane; Single-pass type I membrane protein

Mass spectrometry: Mass=54222.91; Method=MALDI; Range=31-510; Source=PubMed:11840567;

Secondary accessions: Q12895 Q8N5I7 Q9UQG1 Q9UQG2 Q9UQG3 Q9UQG4 Q9UQG5 Q9UQG6 Q9UQG7 Q9UQG8 Q9UQG9

Q9UQH0 Q9UQH1 Q9UQH2

Post-translational modifications:

The N-terminal may be partly blocked¹

REFSEQ proteins: NP_005561.1

ENSEMBL proteins:

ENSP00000251047

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for LMAN1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (LMAN1)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: LMAN1

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	7876089
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	7876089
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for LMAN1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for LMAN1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (LMAN1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for LMAN1

Assays for LMAN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49257

ProtoNet protein and cluster: P49257

1 Blocks protein family: IPB005052 Legume-like lectin

UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257

Similarity: Contains 1 L-type lectin-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LMAN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005570

Applied Biosystems Silencer® siRNAs for LMAN1

Sigma-Aldrich siRNA and siRNA Panels for LMAN1

Sigma-Aldrich shRNA Panels and shRNA for LMAN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LMAN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005570
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005570
untagged cDNA clone in CMV expression vector: NM_005570

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005570

UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257

Function: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or

glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins,

lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi

transport of selected proteins

Genatlas biochemistry entry for LMAN1:

intracellular mannose specific lectin,with homology to galectin,involved in the transport of early

processed glycoprotein from endoplasmic reticulum to Golgi

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005529	sugar binding	IEA	--
GO:0005537	mannose binding	TAS	7876089
GO:0051082	unfolded protein binding	TAS	9546392

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LMAN1

5/13 Interacting proteins for LMAN1 (P49257² ENSP00000251047³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERP44	Q9BS26², ENSP00000262455³	MINT-6174085 MINT-6174046 MINT-6174031 STRING (score=.891)
USO1	O60763², ENSP00000264904³	MINT-6174085 STRING (score=.816)
SNX9	Q9Y5X1²	MINT-61337
MCFD2	ENSP00000317271³	STRING (score=.996)
F8	ENSP00000327895³	STRING (score=.993)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	TAS	9546392
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	9546392
GO:0007596	blood coagulation	TAS	9546392
GO:0015031	protein transport	IEA	--
GO:0016192	vesicle-mediated transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for LMAN1:

Antagonist Blocker Inhibitor

Browse Tocris compounds for LMAN1
4 Novoseek chemical compound relationships for LMAN1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose	41.40	9	8868475 (3), 7876089 (2), 16044454 (1), 12654830 (1)
asparagine	37.80	4	8868475 (1)
lysine	5.54	2	8119975 (2)
glucose	0.00	1	8868475 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LMAN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005570

Sigma-Aldrich siRNA and siRNA Panels for LMAN1

Sigma-Aldrich shRNA Panels and shRNA for LMAN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005570

REFSEQ mRNAs for LMAN1 gene:

NM_005570.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005570

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005570
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005570
                                 untagged cDNA clone in CMV expression vector: NM_005570

Additional cDNA sequence:

AK025773.1 AK223208.1 AK225108.1 AK225111.1 AK301244.1 AK312869.1 BC008401.1 BC017858.1

BC032330.1 CR592087.1 CR599221.1 CR600055.1 CR609154.1 CR618370.1 CR625542.1 U09716.1

X71661.1

23 DOTS entries:

DT.100803248 DT.91977945 DT.100803239 DT.100714983 DT.100775782 DT.100803243 DT.95194342 DT.100028977

DT.119596 DT.92449210 DT.100803237 DT.119597 DT.75190352 DT.75190833 DT.92449203 DT.95123783

DT.100803245 DT.91657707 DT.95123808 DT.95209221 DT.97815490 DT.99974752 DT.100722013

24/424 AceView cDNA sequences (see all 424 ):

CR592087 AW613457 CB119446 AA789062 T30277 AU127736 F01830 AI074164

AA442685 AW272648 BQ020103 AA343952 CN484164 BX348814 AV685092 AA425690

BC032330 CB164270 BU607838 AI280513 AI075150 AA459256 AW340515 AA459481

highest scoring ESTs for LMAN1:

X71661 AA223421 AI523946 AL530615 AU098546 BC032330 BE675859 BF061705 BF105076 BF317418

Unigene Cluster for LMAN1:

Lectin, mannose-binding, 1

Hs.465295 [show with all ESTs]

Unigene Representative Sequence: NM_005570

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000251047

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LMAN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LMAN1

¹ / ² / ³

9 probe-sets matching LMAN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64263_s_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.61	AA725421	0.60	1.00	0.82	1
34734_at²^{, 3}	U95-A	1	0.94	1.00	0.85	0.43	X71661	1.00	1.00	1.00	1
65907_r_at²^{, 3}	U95-C	1	0.62	1.00	0.86	0.97	AI421880	0.60	1.00	0.82	1
224629_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF217539	0.40	1.00	0.76	1
203294_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U09716	0.80	1.00	0.91	1
203293_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005570	0.60	1.00	0.82	1
224629_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203294_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203293_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LMAN1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGCTTATTGA

SOURCE GeneReport for Unigene cluster: Hs.465295
Expression variation in blood from EXPOLDB for LMAN1
UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LMAN1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LMAN1¹	--	lectin, mannose-binding, 1	90.33(n) 90.98(a)	476186 XM_533390.2 XP_533390.2
chimpanzee (Pan troglodytes)	LMAN1¹	--	lectin, mannose-binding, 1	99.15(n) 99.22(a)	455448 XM_001143039.1 XP_001143039.1
cow (Bos taurus)	LMAN1¹	--	lectin, mannose-binding, 1	84.66(n) 86.11(a)	511649 XM_589028.3 XP_589028.3
rat (Rattus norvegicus)	Lman1¹	--	lectin, mannose-binding, 1	85.33(n) 89.19(a)	116666 NM_053886.1 NP_446338.1
mouse (Mus musculus)	Lman1^{1, 5}	18⁵	lectin, mannose-binding, 1^{1, 5}	85.79(n)¹ 89(a)¹	70361¹ NM_027400.2¹ NP_081676.1¹ AI326273⁵ AI787074⁵ (see all 21)

About this table Species with no ortholog for LMAN1

ENSEMBL Gene Tree for LMAN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LMAN1 gene

LMAN2² LMAN2L² LMAN1L²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/240 NCBI SNPs in LMAN1 are shown (see all 240 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 86)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2298711^1,2	C,F,H,O	55151449(-)	`ATTCCA/TTGAGT`	1	M/L	mis¹		7	NA EU EA WA	560
	rs33926449^1,2	C,F	55177341(+)	`ACGCGA/GCCGCG`	1	V/A	mis¹		1	NA	68
	rs3737392^1,2	F,H	55157057(+)	`CAAGAA/GTCATA`	1	I/T	mis¹ ese³		4	EU EA WA	406
	rs2298713^1,2	H	55149284(-)	`GTACTT/GCATCT`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs1043302^1,2	C	55177416(-)	`AGTTCG/AGCCGC`	1	Q/R	mis¹ ese³		2	MN NA	258
	rs1127220^1,2	C,F,H	55173734(-)	`GGTCGA/GATTGG`	1	R/R	syn¹		6	EA EU WA NA	1976
	rs1373525^1,2	A,C,F,H,O	55169213(+)	`CTTTGG/ACTGTG`	1	--	int¹		15	EA NA EU WA	1154
	rs2298712^1,2	A,C,F,H	55151283(-)	`TTTTCC/TTTTTA`	1	--	int¹ trp³		5	EA EU WA	1888
	rs7243056^1,2	A,C,F,H	55172529(+)	`CCATGG/TTTGAA`	1	--	int¹		4	EU EA WA	418
	rs1444488^1,2	A,C,F,H	55163556(-)	`AGAACG/TTGAGT`	1	--	int¹		12	EA NA EU WA	1052

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HapMap Linkage Disequilibrium images for LMAN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601567 disorders: 227300

UniProtKB/Swiss-Prot: LMAN1_HUMAN, P49257

Defects in LMAN1 are a cause of factor V and factor VIII combined deficiency (F5F8D)

[MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D is an

autosomal recessive bleeding disorder characterized by coordinate reduction of both clotting

proteins. Affected patients present with a moderate bleeding tendency and have factor V and factor

VIII levels in the range of 5-30% of normal

6 Novoseek disease relationships for LMAN1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
f5f8d	98.51	34	16304051 (4), 19141160 (4), 16044454 (3), 10090934 (3) (see all 12)
coagulation factor deficiency	79.35	3	17010120 (1), 16044454 (1), 15333032 (1)
coagulopathy	68.22	9	10090934 (2), 14629470 (1), 16044454 (1), 18056485 (1) (see all 8)
hemophilia a	62.72	4	17971482 (1), 15166951 (1), 18685427 (1)
protein deficiency	51.21	2	17010120 (1), 15849265 (1)
bleeding	1.11	1	19183188 (1)

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Genatlas disease: LMAN1

bleeding diathesis,mild to moderate,with combined factor V/factor VIII deficiency

Human Gene Mutation Database: LMAN1
Genetic Association Database: LMAN1
Human Genome Epidemiology Navigator: LMAN1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/108 PubMed articles for LMAN1 gene (see all 108 ):

ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells. (PubMed id 7876089)^{1, 3, 4} Arar C....Roche A.-C. (1995)
A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia. (PubMed id 15166951)^{1, 3, 6} Segal A....Seligsohn U. (2004)
ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. (PubMed id 10090935)^{1, 3, 4} Nichols W.C....Seligsohn U. (1999)
ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. (PubMed id 8223692)^{1, 3, 4} Schindler R.... Hauri H.-P. (1993)
Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. (PubMed id 9546392)^{1, 2, 3} Nichols W.C....Ginsburg D. (1998)
Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the Strong Heart Study. (PubMed id 14732744)^{3, 6} Best L.G....Ferrell R.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. (PubMed id 14593599)^{3, 6} Garred P....Madsen H.O. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain. (PubMed id 12672193)^{3, 6} Garcia-Laorden M.I....Rodriguez-Gallego C. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3998	HGNC: 6631	AceView: LMAN1	Ensembl:ENSG00000074695	euGenes: HUgn3998
ECgene: LMAN1	H-InvDB: LMAN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LMAN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LMAN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LMAN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LMAN1		Antibodies for LMAN1
	Explore super-pooled esiRNAs		Proteins for LMAN1
	Lentivirus-delivered shRNAs for LMAN1		Small molecules for LMAN1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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Antibodies for LMAN1

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LMAN1 Gene at Home site.
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LMAN1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for LMAN1

Summaries
for LMAN1

Genomic Location
for LMAN1

Proteins
for LMAN1

Protein Domains/
Families
for LMAN1

Gene Function
for LMAN1

Pathways & Interactions
for LMAN1

Drugs & Compounds
for LMAN1

Transcripts
for LMAN1

Expression
for LMAN1

Orthologs
for LMAN1

Paralogs
for LMAN1

SNPs/Variants
for LMAN1

Disorders & Mutations
for LMAN1

Medical News
for LMAN1

Publications
for LMAN1

Search for LMAN1

Genome Databases showing LMAN1

Other Databases showing LMAN1

Specialized Databases showing LMAN1

Licensable Technologies
for LMAN1

Services
for LMAN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LMAN1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor LMAN1

Summariesfor LMAN1

Genomic Locationfor LMAN1

Proteinsfor LMAN1

Protein Domains/Familiesfor LMAN1

Gene Functionfor LMAN1

Pathways & Interactionsfor LMAN1

Drugs & Compoundsfor LMAN1

Transcriptsfor LMAN1

Expression for LMAN1

Orthologsfor LMAN1

Paralogsfor LMAN1

SNPs/Variantsfor LMAN1

Disorders & Mutationsfor LMAN1

Medical Newsfor LMAN1

Publicationsfor LMAN1

Search for LMAN1

Genome Databases showing LMAN1

Other Databases showing LMAN1

Specialized Databases showing LMAN1

Licensable Technologiesfor LMAN1

Servicesfor LMAN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LMAN1

Summaries
for LMAN1

Genomic Location
for LMAN1

Proteins
for LMAN1

Protein Domains/
Families
for LMAN1

Gene Function
for LMAN1

Pathways & Interactions
for LMAN1

Drugs & Compounds
for LMAN1

Transcripts
for LMAN1

Expression
for LMAN1

Orthologs
for LMAN1

Paralogs
for LMAN1

SNPs/Variants
for LMAN1

Disorders & Mutations
for LMAN1

Medical News
for LMAN1

Publications
for LMAN1

Licensable Technologies
for LMAN1

Services
for LMAN1