Aliases for LLGL2 Gene
Previous GeneCards Identifiers for LLGL2 Gene
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for LLGL2 Gene
LLGL2 (LLGL2, Scribble Cell Polarity Complex Component) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Tight junction. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is STXBP5L.
UniProtKB/Swiss-Prot for LLGL2 Gene
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.