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Aliases for LLGL2 Gene

Aliases for LLGL2 Gene

  • LLGL2, Scribble Cell Polarity Complex Component 2 3
  • Lethal Giant Larvae Homolog 2, Scribble Cell Polarity Complex Component 2 3
  • Lethal Giant Larvae Homolog 2 (Drosophila) 2 5
  • HGL 3 4
  • Lethal Giant Larvae Homolog 2 3
  • Human Giant Larvae Homolog 3
  • Hugl-2 3
  • LGL2 3

External Ids for LLGL2 Gene

Previous GeneCards Identifiers for LLGL2 Gene

  • GC17P073507
  • GC17P076565
  • GC17P073985
  • GC17P074118
  • GC17P071033
  • GC17P073521
  • GC17P068945

Summaries for LLGL2 Gene

Entrez Gene Summary for LLGL2 Gene

  • The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for LLGL2 Gene

LLGL2 (LLGL2, Scribble Cell Polarity Complex Component) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Tight junction. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is STXBP5L.

UniProtKB/Swiss-Prot for LLGL2 Gene

  • Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LLGL2 Gene

Genomics for LLGL2 Gene

Regulatory Elements for LLGL2 Gene

Enhancers for LLGL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LLGL2 on UCSC Golden Path with GeneCards custom track

Promoters for LLGL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LLGL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LLGL2 Gene

Chromosome:
17
Start:
75,525,080 bp from pter
End:
75,575,209 bp from pter
Size:
50,130 bases
Orientation:
Plus strand

Genomic View for LLGL2 Gene

Genes around LLGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LLGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LLGL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LLGL2 Gene

Proteins for LLGL2 Gene

  • Protein details for LLGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1M3-L2GL2_HUMAN
    Recommended name:
    Lethal(2) giant larvae protein homolog 2
    Protein Accession:
    Q6P1M3
    Secondary Accessions:
    • Q14521
    • Q9BR62

    Protein attributes for LLGL2 Gene

    Size:
    1020 amino acids
    Molecular mass:
    113448 Da
    Quaternary structure:
    • Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. Interacts with VPRBP.
    Miscellaneous:
    • Overexpression of LLGL2 inhibits the tight junction formation.

    Three dimensional structures from OCA and Proteopedia for LLGL2 Gene

    Alternative splice isoforms for LLGL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LLGL2 Gene

Proteomics data for LLGL2 Gene at MOPED

Post-translational modifications for LLGL2 Gene

  • Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.
  • Ubiquitination at Lys 625 and Lys 724
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LLGL2 Gene

Domains & Families for LLGL2 Gene

Gene Families for LLGL2 Gene

Suggested Antigen Peptide Sequences for LLGL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1M3

UniProtKB/Swiss-Prot:

L2GL2_HUMAN :
  • Belongs to the WD repeat L(2)GL family.
  • Contains 14 WD repeats.
Family:
  • Belongs to the WD repeat L(2)GL family.
Similarity:
  • Contains 14 WD repeats.
genes like me logo Genes that share domains with LLGL2: view

Function for LLGL2 Gene

Molecular function for LLGL2 Gene

GENATLAS Biochemistry:
protein homolog of DLG1 (Drosophila lethal giant larvae 1) and C52A11.4 (C. elegans)
UniProtKB/Swiss-Prot Function:
Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.

Gene Ontology (GO) - Molecular Function for LLGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030165 PDZ domain binding IPI 12725730
genes like me logo Genes that share ontologies with LLGL2: view
genes like me logo Genes that share phenotypes with LLGL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LLGL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LLGL2 Gene

Localization for LLGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LLGL2 Gene

Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LLGL2 Gene COMPARTMENTS Subcellular localization image for LLGL2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LLGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with LLGL2: view

Pathways & Interactions for LLGL2 Gene

genes like me logo Genes that share pathways with LLGL2: view

Pathways by source for LLGL2 Gene

2 KEGG pathways for LLGL2 Gene
2 Qiagen pathways for LLGL2 Gene

Gene Ontology (GO) - Biological Process for LLGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008593 regulation of Notch signaling pathway IBA --
GO:0030866 cortical actin cytoskeleton organization IBA --
GO:0032878 regulation of establishment or maintenance of cell polarity IDA 12725730
GO:0050708 regulation of protein secretion IBA --
genes like me logo Genes that share ontologies with LLGL2: view

No data available for SIGNOR curated interactions for LLGL2 Gene

Drugs & Compounds for LLGL2 Gene

(1) Drugs for LLGL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LLGL2: view

Transcripts for LLGL2 Gene

Unigene Clusters for LLGL2 Gene

Lethal giant larvae homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LLGL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13: -
SP14: -
SP15:
SP16:

ExUns: 16b ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7: - -
SP8: -
SP9:
SP10: -
SP11: -
SP12: - -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for LLGL2 Gene

GeneLoc Exon Structure for
LLGL2
ECgene alternative splicing isoforms for
LLGL2

Expression for LLGL2 Gene

mRNA expression in normal human tissues for LLGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LLGL2 Gene

This gene is overexpressed in Colon - Transverse (x6.7) and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for LLGL2 Gene

This gene is overexpressed in Islet of Langerhans (12.3), Pancreas (9.7), Cervix (7.5), Placenta (6.8), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LLGL2 Gene



SOURCE GeneReport for Unigene cluster for LLGL2 Gene Hs.514477

genes like me logo Genes that share expression patterns with LLGL2: view

Protein tissue co-expression partners for LLGL2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LLGL2 Gene

Orthologs for LLGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LLGL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LLGL2 35
  • 88.92 (n)
  • 90.88 (a)
LLGL2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LLGL2 35
  • 89.22 (n)
  • 92.16 (a)
LLGL2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Llgl2 35
  • 86.63 (n)
  • 91.08 (a)
Llgl2 16
Llgl2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LLGL2 35
  • 99.38 (n)
  • 99.41 (a)
LLGL2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Llgl2 35
  • 86.86 (n)
  • 90.78 (a)
oppossum
(Monodelphis domestica)
Mammalia LLGL2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LLGL2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LLGL2 35
  • 71.14 (n)
  • 77.55 (a)
LLGL2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LLGL2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia llgl2 35
  • 68.37 (n)
  • 70.67 (a)
Str.1582 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14793 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3566 35
llgl2 35
  • 66.11 (n)
  • 66.93 (a)
llgl2 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(2)gl 37
  • 35 (a)
l(2)gl 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lgl-1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for LLGL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LLGL2 Gene

ENSEMBL:
Gene Tree for LLGL2 (if available)
TreeFam:
Gene Tree for LLGL2 (if available)

Paralogs for LLGL2 Gene

Paralogs for LLGL2 Gene

genes like me logo Genes that share paralogs with LLGL2: view

Variants for LLGL2 Gene

Sequence variations from dbSNP and Humsavar for LLGL2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs35474687 - 75,571,733(+) CCTGC(A/G)TGTGC reference, missense
rs35886912 - 75,574,614(+) GGAGC(A/G)GCAAC downstream-variant-500B, reference, synonymous-codon, missense
rs1671036 - 75,556,104(-) GGATG(C/T)GCAGG reference, missense, utr-variant-5-prime
rs1671021 -, - 75,569,090(-) ACTGA(A/G)GTTCT reference, missense
rs35991442 - 75,569,119(+) TGGCC(C/T)CCACT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LLGL2 Gene

Variant ID Type Subtype PubMed ID
nsv516133 CNV Loss 19592680
nsv908762 CNV Loss 21882294
nsv833542 CNV Loss 17160897
nsv908763 CNV Gain 21882294
dgv3256n71 CNV Loss 21882294
nsv470603 CNV Loss 18288195
dgv3257n71 CNV Loss 21882294
dgv3258n71 CNV Loss 21882294
nsv908775 CNV Loss 21882294
nsv828102 CNV Loss 20364138
nsv833543 CNV Loss 17160897
esv273022 CNV Insertion 20981092
nsv908777 CNV Loss 21882294
dgv3259n71 CNV Loss 21882294
dgv3260n71 CNV Loss 21882294
esv3480 CNV Deletion 18987735
esv22892 CNV Loss 19812545
nsv820595 CNV Deletion 20802225
esv1007606 CNV Deletion 20482838
esv2716239 CNV Deletion 23290073
esv2716241 CNV Deletion 23290073
esv2716242 CNV Deletion 23290073
esv2286878 CNV Deletion 18987734
esv1010854 CNV Deletion 20482838
esv2716243 CNV Deletion 23290073
esv2716244 CNV Deletion 23290073
esv2716245 CNV Deletion 23290073
nsv908783 CNV Loss 21882294
dgv3261n71 CNV Loss 21882294
dgv3262n71 CNV Loss 21882294
nsv908786 CNV Loss 21882294

Variation tolerance for LLGL2 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.67; 99.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LLGL2 Gene

HapMap Linkage Disequilibrium report
LLGL2
Human Gene Mutation Database (HGMD)
LLGL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LLGL2 Gene

Disorders for LLGL2 Gene

Relevant External Links for LLGL2

Genetic Association Database (GAD)
LLGL2
Human Genome Epidemiology (HuGE) Navigator
LLGL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LLGL2

No disorders were found for LLGL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LLGL2 Gene

Publications for LLGL2 Gene

  1. The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis. (PMID: 22580609) Kashyap A. … Strand D. (Oncogene 2013) 2 3 67
  2. Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene. (PMID: 18155665) Zimmermann T. … Strand D. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for LLGL2 Gene

Sources for LLGL2 Gene

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