LLGL1 Gene
protein-coding GIFtS: 61
GCID: GC17P018128
|
|
lethal giant larvae homolog 1 (Drosophila)(Previous name: lethal giant larvae (Drosophila) homolog 1 )
(Previous symbols: DLG4, LLGL, HUGL, HUGL-1)
| |
Aliases
for LLGL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lethal Giant Larvae Homolog 1 (Drosophila)1 2 | | Human Homolog To The D-Lgl Gene Protein2 3 | | DLG41 2 3 5 | | HUGL12 3 | | HUGL1 2 3 | | Lethal Giant Larvae (Drosophila) Homolog 11 | | LLGL1 2 3 | | Lethal(2) Giant Larvae Protein Homolog 12 | | HUGL-11 2 | | Hugl-13 |
Export aliases for LLGL1 gene to outside databasesPrevious GC identifers: GC17P018374 GC17P019502 GC17P018071 GC17P018329 GC17P018069 GC17P017886 |
Summaries
for LLGL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LLGL1:
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletalnetwork and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates thisprotein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: L2GL1_HUMAN, Q15334Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelialintegrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissueorganization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicularmembrane trafficking toward the axonal plasma membrane
Gene Wiki entry for LLGL1
|
Genomic Views
for LLGL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LLGL1 gene promoter:
RFX1 Pax-5 HOXA3 AML1a Tal-1 GATA-3 FOXD1 E47 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LLGL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LLGL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2LLGL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P018128: view genomic region
(about GC identifiers)
Start:
|
18,128,901 bp from pter |
End:
|
18,148,189 bp from pter |
Size:
|
19,289 bases |
Orientation:
|
plus strand |
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Proteins
for LLGL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: L2GL1_HUMAN, Q15334 (See
protein sequence)Recommended Name: Lethal(2) giant larvae protein homolog 1 Size: 1064 amino acids; 115418 Da
Subunit: Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interactswith STX4A (By similarity). Interacts with RAB10 (GDP-bound form); the interaction is direct and promotes RAB10association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity)
Subcellular location: Early endosome membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (Bysimilarity). Golgi apparatus membrane (By similarity). Cell projection, axon (By similarity). Cytoplasm, cytoskeleton.Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched indevelopping axons (By similarity)
Miscellaneous: Down-regulation of LLGL1 is associated with the progression of colorectal cancer and melanoma. Locatedwithin the Smith-Magenis syndrome region on chromosome 17; deleted in patients with this syndrome
Miscellaneous: Expression increases cell adhesion and decreases cell migration. Substitutes for Drosophila l(2)gl tumorsuppressor function in vivo
Sequence caution: Sequence=BAA19516.1; Type=Frameshift; Positions=205, 216, 737, 740, 794, 799, 866, 872, 881, 945,968, 1024;
Secondary accessions: A7MBM7 O00188 Q58F11 Q86UK6Explore the universe of human proteins at neXtProt for LLGL1: NX_Q15334
Post-translational modifications:
Phosphorylated at least at Ser-663 by PRKCI1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15334
LLGL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004131.3
ENSEMBL proteins: ENSP00000321537
Human Recombinant Protein Products for LLGL1:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
LLGL1 for ontologies About GeneDecksing
LLGL1 Antibody Products:
Assay Products for LLGL1: |
Protein
Domains /
Families
for LLGL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LLGL1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q15334ProtoNet protein and cluster: Q15334 1 Blocks protein family: IPB000664 Lethal(2) giant larvae protein signature
UniProtKB/Swiss-Prot: L2GL1_HUMAN, Q15334Similarity: Belongs to the WD repeat L(2)GL familySimilarity: Contains 14 WD repeats |
Function
for LLGL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: L2GL1_HUMAN, Q15334Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelialintegrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissueorganization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicularmembrane trafficking toward the axonal plasma membrane Genatlas biochemistry entry for LLGL1:Drosophila tumor suppressor gene lethal (2) giant larvae (115kDa) homolog,deleted in Smith-Magenis syndrome
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
LLGL1 for ontologies About GeneDecksing
Phenotypes:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Llgl1):
LLGL1 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Llgl1tm1.1Vv for LLGL1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LLGL1 (NM_004140) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LLGL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LLGL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LLGL1 |
|
Pathways & Interactions
for LLGL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Tight junction | | | 3 | Sertoli-Sertoli Cell Junction Dynamics | | | 4 | Actin Nucleation by ARP-WASP Complex | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LLGL1
1 
Cell Signaling Technology (CST) Pathway for LLGL1
1 
Kegg Pathway (Kegg details for LLGL1):
LLGL1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LLGL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/28 Interacting proteins for LLGL1 (Q153342, 3 ENSP000003215374) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
LLGL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LLGL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LLGL1
Search CenterWatch for drugs/clinical trials and news about LLGL1 / L2GL1
|
Transcripts
for LLGL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LLGL1 gene: NM_004140.3 Unigene Cluster for LLGL1: Lethal giant larvae homolog 1 (Drosophila) Hs.513983 [show with all ESTs]Unigene Representative Sequence: NM_0041402 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316843(uc002gsp.3) ENST00000479155
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LLGL1 (NM_004140) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LLGL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LLGL1 |
Additional cDNA sequence: BC028037.1 BC028214.1 BC151838.1 8 DOTS entries: DT.101981432 DT.120997780 DT.95270197 DT.95291769 DT.91671937 DT.75169954 DT.120997748 DT.120997769 24/465 AceView cDNA sequences (see all 465): AI992008 BM764393 AI242805 BF432071 AI302321 BM767633 BM766674 BM767576 BC028037 BM997112 BM767580 AI279597 AI937622 AW341164 AA495948 BQ899215 BM767653 AI140129 AW341144 AI130980 BM766617 BM844782 AI417829 AI698008
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for LLGL1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LLGL1
|
Expression
for LLGL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LLGL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGTGACTG
About this image
See LLGL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LLGL1
SOURCE GeneReport for Unigene cluster: Hs.513983
UniProtKB/Swiss-Prot: L2GL1_HUMAN, Q15334Tissue specificity: Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated orlost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of thedisease
SABiosciences Expression via Pathway-Focused PCR Arrays including LLGL1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LLGL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LLGL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LLGL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LLGL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LLGL1 |
Orthologs
for LLGL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LLGL1 gene from 4/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LLGL11 |
lethal giant larvae homolog 1 (Drosophila) |
75.48(n)
74.95(a) |
|
100858027 XM_003642145.1 XP_003642193.1 |
lizard
(Anolis carolinensis) |
Reptilia |
LLGL16 |
-- |
74(a) |
1 ↔ 1 |
GL343618.1(95690-127888) |
zebrafish
(Danio rerio) |
Actinopterygii |
llgl16 |
lethal giant larvae homolog 1 (Drosophila) |
70(a) |
1 ↔ 1 |
3(39965137-40049531) |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(2)gl1 , 3 |
TGFbeta receptor signaling pathway myosin
binding3
lethal (2) giant larvae1 |
37(a)3
46.85(n)1
41.16(a)1 |
|
2 21A23
331561 NM_164349.21 NP_722584.11 |
ENSEMBL Gene Tree for LLGL1 (if available)
TreeFam Gene Tree for LLGL1 (if available) |
Paralogs
for LLGL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LLGL1 gene
- LLGL22 STXBP52 STXBP5L2
3 SIMAP similar genes for LLGL1 using alignment to 2 protein entries: L2GL1_HUMAN (see all proteins):LLGL2 STXBP5L STXBP5
LLGL1 for paralogs About GeneDecksing
|
Genomic Variants
for LLGL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LLGL1 (18128901 - 18148189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for LLGL1
2 CNVs: 72809 30807
1 Inversion: 0495
Human Gene Mutation Database (HGMD): LLGL1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LLGL1 |
|
Disorders
/ Diseases
for LLGL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LLGL1 for disorders About GeneDecksing
OMIM gene information: 600966
OMIM disorders: --
7  diseases for LLGL1: About MalaCardssmith-magenis syndrome macular degeneration endometrial cancer colorectal cancer
ataxia melanoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: LLGL1 (3 documents)
Export disorders for LLGL1 gene to outside databases
|
Publications
for LLGL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LLGL1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with LLGL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. (PubMed id 7542763)1, 2, 3, 9 Strand D.J.... Mechler B. (1995)
- The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2. (PubMed id 8565641)1, 2, 3 Koyama K....Nakamura Y. (1996)
- Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. (PubMed id 15735678)1, 2, 9 Schimanski C.C....Strand D. (2005)
- Expression of Hugl-1 is strongly reduced in malignant melanoma. (PubMed id 16170365)1, 2 Kuphal S.... Bosserhoff A.K. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. (PubMed id 12725730)1, 2 Yamanaka T.... Ohno S. (2003)
- aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. (PubMed id 17369850)1, 9 Grifoni D....Pession A. (2007)
- Preservation of HUGL-1 expression as a favourable prog nostic factor in pancreatic carcinoma. (PubMed id 22843887)1 Biesterfeld S....Galle P.R. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
|
External Searches for LLGL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LLGL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LLGL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LLGL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LLGL1 gene:
Search GeneIP for patents involving LLGL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LLGL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LLGL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LLGL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LLGL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LLGL1 | | OriGene 3'-UTR Clone for LLGL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LLGL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LLGL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LLGL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LLGL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LLGL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LLGL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LLGL1 |
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| | Antibodies & Assays for LLGL1 |
| | | | Search Tocris compounds for LLGL1 |
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 | | | LLGL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LLGL1 |
|  |  |  |  | | | | ThermoFisher Antibodies for LLGL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LLGL1 |
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