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Aliases for LIPM Gene

Aliases for LIPM Gene

  • Lipase Family Member M 2 3 5
  • Lipase-Like Abhydrolase Domain-Containing Protein 3 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 3 2 3
  • LIPL3 3 4
  • Lipase Member M 3
  • EC 3.1.1.13 61
  • EC 3.1.1.3 61
  • EC 3.1.1.- 4
  • BA304I5.1 3
  • Lipase M 3
  • EC 3.1.1 61

External Ids for LIPM Gene

Previous HGNC Symbols for LIPM Gene

  • LIPL3

Previous GeneCards Identifiers for LIPM Gene

  • GC10P090553
  • GC10P084197

Summaries for LIPM Gene

GeneCards Summary for LIPM Gene

LIPM (Lipase Family Member M) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPA.

UniProtKB/Swiss-Prot for LIPM Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPM Gene

Genomics for LIPM Gene

Regulatory Elements for LIPM Gene

Enhancers for LIPM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F088824 0.2 ENCODE 16.1 +23.0 22966 3.1 TBP PKNOX1 MTA2 ASH2L BMI1 TBX21 EP300 ZNF664 SP1 POLR2A ANKRD22 LIPM ACTA2-AS1 STAMBPL1 ENSG00000201548 LIPJ RNLS LIPF FAS LIPN
GH10F088833 1.3 FANTOM5 Ensembl ENCODE 10.5 +31.1 31071 0.8 CTCF ZNF664 SMC3 RAD21 STAMBPL1 ANKRD22 ACTA2-AS1 LIPM LIPJ ENSG00000201548 RNLS LIPF LIPN FAS
GH10F088830 0.5 ENCODE 10.5 +28.2 28164 0.5 MTA2 JUNB RELA ANKRD22 ACTA2-AS1 STAMBPL1 LIPM ENSG00000201548 LIPJ RNLS LIPF
GH10F088831 0.6 ENCODE 10.5 +29.2 29169 0.2 ZNF263 HIC1 ZFP37 WT1 TRIM28 ANKRD22 ACTA2-AS1 STAMBPL1 LIPM ENSG00000201548 LIPJ RNLS LIPF
GH10F088767 0.3 FANTOM5 10.2 -35.0 -34954 0.3 ZNF362 SCRT2 LIPM ENSG00000201548 LIPJ RNLS LIPN ANKRD22 RCBTB2P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LIPM on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPM Gene

Chromosome:
10
Start:
88,802,730 bp from pter
End:
88,822,022 bp from pter
Size:
19,293 bases
Orientation:
Plus strand

Genomic View for LIPM Gene

Genes around LIPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPM Gene

Proteins for LIPM Gene

  • Protein details for LIPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYY2-LIPM_HUMAN
    Recommended name:
    Lipase member M
    Protein Accession:
    Q5VYY2
    Secondary Accessions:
    • A6PVS3
    • B2RXK7
    • B5MCR3

    Protein attributes for LIPM Gene

    Size:
    423 amino acids
    Molecular mass:
    48233 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIPM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPM Gene

Selected DME Specific Peptides for LIPM Gene

Q5VYY2:
  • WSRKHKTLS
  • LHWSQAV
  • TEDGYIL
  • FILADAG
  • NLPNNSL

Post-translational modifications for LIPM Gene

  • Glycosylation at Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPM Gene

Domains & Families for LIPM Gene

Gene Families for LIPM Gene

Protein Domains for LIPM Gene

Suggested Antigen Peptide Sequences for LIPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VYY2

UniProtKB/Swiss-Prot:

LIPM_HUMAN :
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPM: view

Function for LIPM Gene

Molecular function for LIPM Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPM Gene

Gene Ontology (GO) - Molecular Function for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPM: view
genes like me logo Genes that share phenotypes with LIPM: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPM Gene

Localization for LIPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPM Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPM Gene COMPARTMENTS Subcellular localization image for LIPM gene
Compartment Confidence
extracellular 5
lysosome 2
mitochondrion 2
vacuole 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with LIPM: view

Pathways & Interactions for LIPM Gene

genes like me logo Genes that share pathways with LIPM: view

Gene Ontology (GO) - Biological Process for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPM: view

No data available for SIGNOR curated interactions for LIPM Gene

Transcripts for LIPM Gene

mRNA/cDNA for LIPM Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPM Gene

Lipase, family member M:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPM Gene

No ASD Table

Relevant External Links for LIPM Gene

GeneLoc Exon Structure for
LIPM
ECgene alternative splicing isoforms for
LIPM

Expression for LIPM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPM Gene

mRNA differential expression in normal tissues according to GTEx for LIPM Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.2) and Skin - Not Sun Exposed (Suprapubic) (x19.0).

NURSA nuclear receptor signaling pathways regulating expression of LIPM Gene:

LIPM

SOURCE GeneReport for Unigene cluster for LIPM Gene:

Hs.55118

mRNA Expression by UniProt/SwissProt for LIPM Gene:

Q5VYY2-LIPM_HUMAN
Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.
genes like me logo Genes that share expression patterns with LIPM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LIPM Gene

Orthologs for LIPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPM 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia LIPM 34 35
  • 89.2 (n)
rat
(Rattus norvegicus)
Mammalia Lipm 34
  • 85.78 (n)
mouse
(Mus musculus)
Mammalia Lipm 34 16 35
  • 85.47 (n)
dog
(Canis familiaris)
Mammalia LIPM 34 35
  • 85.2 (n)
oppossum
(Monodelphis domestica)
Mammalia LIPM 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIPM 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia LIPM 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10481 34
fruit fly
(Drosophila melanogaster)
Insecta CG31871 34
  • 48.9 (n)
CG18530 35
  • 29 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002872 34
  • 46.59 (n)
worm
(Caenorhabditis elegans)
Secernentea lipl-5 35
  • 39 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for LIPM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPM Gene

ENSEMBL:
Gene Tree for LIPM (if available)
TreeFam:
Gene Tree for LIPM (if available)

Paralogs for LIPM Gene

Paralogs for LIPM Gene

(6) SIMAP similar genes for LIPM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPM: view

Variants for LIPM Gene

Sequence variations from dbSNP and Humsavar for LIPM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10509555 -- 88,819,380(+) CAAAA(A/G)AAATT intron-variant
rs10788614 -- 88,802,146(+) ATATA(A/G)TAAAT upstream-variant-2KB
rs10788615 -- 88,820,387(+) GCTCA(C/T)GTGGA reference, synonymous-codon, utr-variant-3-prime
rs111791725 -- 88,813,758(+) TTCAG(A/C)GGGGC intron-variant
rs111798790 -- 88,816,241(+) ATCCT(A/C/G)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPM Gene

Variant ID Type Subtype PubMed ID
esv3624139 CNV gain 21293372
esv3624140 CNV loss 21293372
esv3624141 CNV gain 21293372
esv3624142 CNV loss 21293372
nsv1043015 CNV gain 25217958
nsv551840 CNV gain 21841781
nsv7484 CNV insertion 18451855
nsv831941 CNV gain 17160897
nsv831942 CNV gain 17160897

Variation tolerance for LIPM Gene

Gene Damage Index Score: 5.13; 69.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPM Gene

Disorders for LIPM Gene

Relevant External Links for LIPM

Genetic Association Database (GAD)
LIPM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPM

No disorders were found for LIPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIPM Gene

Publications for LIPM Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3 4 64
  2. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 46 64
  3. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk J.B. … O'Connor G.T. (BMC Med. Genet. 2007) 46 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for LIPM Gene

Sources for LIPM Gene

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