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Aliases for LIPM Gene

Aliases for LIPM Gene

  • Lipase Family Member M 2 3
  • Lipase-Like Abhydrolase Domain-Containing Protein 3 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 3 2 3
  • Lipase, Family Member M 3 5
  • LIPL3 3 4
  • EC 63
  • EC 63
  • EC 3.1.1.- 4
  • BA304I5.1 3
  • Lipase M 3
  • EC 3.1.1 63

External Ids for LIPM Gene

Previous HGNC Symbols for LIPM Gene

  • LIPL3

Previous GeneCards Identifiers for LIPM Gene

  • GC10P090553
  • GC10P084197

Summaries for LIPM Gene

GeneCards Summary for LIPM Gene

LIPM (Lipase Family Member M) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPA.

UniProtKB/Swiss-Prot for LIPM Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPM Gene

Genomics for LIPM Gene

Regulatory Elements for LIPM Gene

Enhancers for LIPM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIPM on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPM Gene

88,802,730 bp from pter
88,822,022 bp from pter
19,293 bases
Plus strand

Genomic View for LIPM Gene

Genes around LIPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPM Gene

Proteins for LIPM Gene

  • Protein details for LIPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member M
    Protein Accession:
    Secondary Accessions:
    • A6PVS3
    • B2RXK7
    • B5MCR3

    Protein attributes for LIPM Gene

    423 amino acids
    Molecular mass:
    48233 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIPM Gene


neXtProt entry for LIPM Gene

Proteomics data for LIPM Gene at MOPED

Selected DME Specific Peptides for LIPM Gene

Post-translational modifications for LIPM Gene

  • Glycosylation at Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPM Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LIPM Gene

Gene Families for LIPM Gene

Protein Domains for LIPM Gene

Suggested Antigen Peptide Sequences for LIPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPM: view

Function for LIPM Gene

Molecular function for LIPM Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPM Gene

genes like me logo Genes that share phenotypes with LIPM: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPM Gene

Localization for LIPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPM Gene


Subcellular locations from

Jensen Localization Image for LIPM Gene COMPARTMENTS Subcellular localization image for LIPM gene
Compartment Confidence
extracellular 5
lysosome 2
mitochondrion 2
vacuole 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LIPM Gene

Pathways & Interactions for LIPM Gene

genes like me logo Genes that share pathways with LIPM: view

Gene Ontology (GO) - Biological Process for LIPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPM: view

No data available for SIGNOR curated interactions for LIPM Gene

Drugs & Compounds for LIPM Gene

No Compound Related Data Available

Transcripts for LIPM Gene

mRNA/cDNA for LIPM Gene

(7) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPM Gene

Lipase, family member M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPM Gene

No ASD Table

Relevant External Links for LIPM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPM Gene

mRNA expression in normal human tissues for LIPM Gene

mRNA differential expression in normal tissues according to GTEx for LIPM Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x22.2) and Skin - Not Sun Exposed (Suprapubic) (x19.0).

SOURCE GeneReport for Unigene cluster for LIPM Gene Hs.55118

mRNA Expression by UniProt/SwissProt for LIPM Gene

Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.
genes like me logo Genes that share expression patterns with LIPM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LIPM Gene

Orthologs for LIPM Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LIPM 35
  • 89.2 (n)
  • 87.94 (a)
  • 89 (a)
(Canis familiaris)
Mammalia LIPM 35
  • 85.2 (n)
  • 87.59 (a)
  • 87 (a)
(Mus musculus)
Mammalia Lipm 35
  • 85.47 (n)
  • 87.44 (a)
Lipm 16
Lipm 36
  • 87 (a)
(Pan troglodytes)
Mammalia LIPM 35
  • 99.37 (n)
  • 99.53 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Lipm 35
  • 85.78 (n)
  • 88.63 (a)
(Monodelphis domestica)
Mammalia LIPM 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia LIPM 36
  • 73 (a)
(Gallus gallus)
Aves -- 36
  • 49 (a)
(Anolis carolinensis)
Reptilia LIPM 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10481 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002872 35
  • 46.59 (n)
  • 36.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31871 35
  • 48.9 (n)
  • 37.64 (a)
CG18530 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea lipl-5 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for LIPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPM Gene

Gene Tree for LIPM (if available)
Gene Tree for LIPM (if available)

Paralogs for LIPM Gene

Paralogs for LIPM Gene

(6) SIMAP similar genes for LIPM Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPM: view

Variants for LIPM Gene

Sequence variations from dbSNP and Humsavar for LIPM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_032191 -
rs3910680 - 88,815,466(-) GAAGT(A/G)ACATG downstream-variant-500B, reference, missense
rs170005 -- 88,808,893(+) AAAAA(A/C/T)GAAAG intron-variant, upstream-variant-2KB
rs188572 -- 88,815,056(-) GAATA(C/T)GAAAT intron-variant
rs303523 -- 88,817,059(+) AACTT(C/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPM Gene

Variant ID Type Subtype PubMed ID
nsv831941 CNV Gain 17160897
nsv7484 CNV Insertion 18451855
esv2739350 CNV Deletion 23290073
nsv831942 CNV Gain 17160897

Variation tolerance for LIPM Gene

Gene Damage Index Score: 5.13; 69.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LIPM Gene

Disorders for LIPM Gene

Relevant External Links for LIPM

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LIPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIPM Gene

Publications for LIPM Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LIPM Gene

Sources for LIPM Gene