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Aliases for LIPK Gene

Aliases for LIPK Gene

  • Lipase Family Member K 2 3 5
  • Lipase-Like Abhydrolase Domain-Containing Protein 2 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 2 2 3
  • LIPL2 3 4
  • Lipase Member K 3
  • EC 3.1.1.13 58
  • BA186O14.2 3
  • EC 3.1.1.3 58
  • EC 3.1.1.- 4
  • Lipase K 3
  • EC 3.1.1 58

External Ids for LIPK Gene

Previous HGNC Symbols for LIPK Gene

  • LIPL2

Previous GeneCards Identifiers for LIPK Gene

  • GC10P090476
  • GC10P084118

Summaries for LIPK Gene

GeneCards Summary for LIPK Gene

LIPK (Lipase Family Member K) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPF.

UniProtKB/Swiss-Prot for LIPK Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Additional gene information for LIPK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPK Gene

Genomics for LIPK Gene

Regulatory Elements for LIPK Gene

Enhancers for LIPK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H088755 0.8 FANTOM5 10.7 +49.7 49675 0.2 PKNOX1 ZBED1 JUNB BATF IKZF1 EED ETV6 RUNX3 IKZF2 CREM KRT8P38 LIPK RNLS LIPJ ENSG00000201548 LIPN
GH10H088383 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -319.1 -319128 7.4 PKNOX1 FEZF1 YY1 GLIS2 ZNF143 ATF7 KLF7 RUNX3 NFYC JUNB KLLN PTEN LIPK GC10P088387 VN1R55P
GH10H088759 0.8 Ensembl ENCODE 6.2 +54.2 54204 2.3 POLR2A MAX MYC GABPA LIPN LIPM LIPF LIPK RCBTB2P1
GH10H088878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +178.0 177982 10.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 KIF20B RPL11P3 STAMBPL1 FAS ACTA2-AS1 ENSG00000201548 RNLS LIPJ LIPM LIPN
GH10H089206 1.1 FANTOM5 ENCODE 2.7 +501.3 501271 2.1 ZSCAN5A MXI1 ZNF777 SUZ12 ZIC2 ZEB1 ZNF324 ZNF664 GLIS2 POLR2A FAS LIPA CH25H LIPK GC10P089210
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPK on UCSC Golden Path with GeneCards custom track

Genomic Locations for LIPK Gene

Genomic Locations for LIPK Gene
chr10:88,706,234-88,753,092
(GRCh38/hg38)
Size:
46,859 bases
Orientation:
Plus strand
chr10:90,484,301-90,512,543
(GRCh37/hg19)

Genomic View for LIPK Gene

Genes around LIPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPK Gene

Proteins for LIPK Gene

  • Protein details for LIPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXJ0-LIPK_HUMAN
    Recommended name:
    Lipase member K
    Protein Accession:
    Q5VXJ0
    Secondary Accessions:
    • A7KIH8

    Protein attributes for LIPK Gene

    Size:
    399 amino acids
    Molecular mass:
    45563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LIPK Gene

Selected DME Specific Peptides for LIPK Gene

Q5VXJ0:
  • EMAKYDLP
  • GNSRGNTW
  • VQNMLHW
  • FFALAPV
  • NLPNNSL
  • HNPAGTS

Post-translational modifications for LIPK Gene

  • Glycosylation at Asn271 and Asn327
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPK Gene

Gene Families for LIPK Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LIPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VXJ0

UniProtKB/Swiss-Prot:

LIPK_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPK: view

Function for LIPK Gene

Molecular function for LIPK Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPK Gene

Gene Ontology (GO) - Molecular Function for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPK: view

Phenotypes for LIPK Gene

genes like me logo Genes that share phenotypes with LIPK: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPK Gene

Localization for LIPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPK gene
Compartment Confidence
extracellular 4
lysosome 3
mitochondrion 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with LIPK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPK Gene

Pathways & Interactions for LIPK Gene

genes like me logo Genes that share pathways with LIPK: view

Interacting Proteins for LIPK Gene

Gene Ontology (GO) - Biological Process for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with LIPK: view

No data available for SIGNOR curated interactions for LIPK Gene

Drugs & Compounds for LIPK Gene

No Compound Related Data Available

Transcripts for LIPK Gene

mRNA/cDNA for LIPK Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPK Gene

Lipase, family member K:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPK Gene

No ASD Table

Relevant External Links for LIPK Gene

GeneLoc Exon Structure for
LIPK
ECgene alternative splicing isoforms for
LIPK

Expression for LIPK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPK Gene

mRNA differential expression in normal tissues according to GTEx for LIPK Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x23.8), Skin - Sun Exposed (Lower leg) (x19.4), and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for LIPK Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPK Gene



Protein tissue co-expression partners for LIPK Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPK Gene:

LIPK

SOURCE GeneReport for Unigene cluster for LIPK Gene:

Hs.632092

mRNA Expression by UniProt/SwissProt for LIPK Gene:

Q5VXJ0-LIPK_HUMAN
Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.

Evidence on tissue expression from TISSUES for LIPK Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with LIPK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPK Gene

Orthologs for LIPK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPK 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia LIPK 33 34
  • 87.21 (n)
mouse
(Mus musculus)
Mammalia Lipk 33 16 34
  • 84.59 (n)
dog
(Canis familiaris)
Mammalia LIPK 33 34
  • 83.38 (n)
rat
(Rattus norvegicus)
Mammalia Lipk 33
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 53 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005185 33
  • 45.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18301 34
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lipl-4 34
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 34
  • 20 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16A3.12c 33
  • 47.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToMany
Species where no ortholog for LIPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPK Gene

ENSEMBL:
Gene Tree for LIPK (if available)
TreeFam:
Gene Tree for LIPK (if available)

Paralogs for LIPK Gene

Paralogs for LIPK Gene

(6) SIMAP similar genes for LIPK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPK: view

Variants for LIPK Gene

Sequence variations from dbSNP and Humsavar for LIPK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000178526 -- 88,746,126(+) CATAA(A/G)ACAAG intron-variant
rs1000206099 -- 88,746,394(+) CTCAA(C/T)AAATT intron-variant
rs1000313386 -- 88,752,488(+) AAAAC(-/TT)TTTTC intron-variant
rs1000351365 -- 88,710,827(+) ACTAC(C/T)TAAAG intron-variant
rs1000359966 -- 88,728,900(+) CCTCT(C/G)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPK Gene

Variant ID Type Subtype PubMed ID
nsv831941 CNV gain 17160897
nsv551840 CNV gain 21841781
nsv1052613 CNV loss 25217958
nsv1043015 CNV gain 25217958
esv3624139 CNV gain 21293372
esv1297628 CNV insertion 17803354

Variation tolerance for LIPK Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPK Gene

Human Gene Mutation Database (HGMD)
LIPK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPK Gene

Disorders for LIPK Gene

Relevant External Links for LIPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPK

No disorders were found for LIPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIPK Gene

Publications for LIPK Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E … Guerrin M (Genome biology 2007) 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 60

Products for LIPK Gene

Sources for LIPK Gene

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