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Aliases for LIPK Gene

Aliases for LIPK Gene

  • Lipase Family Member K 2 3 5
  • Lipase-Like Abhydrolase Domain-Containing Protein 2 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 2 2 3
  • LIPL2 3 4
  • Lipase Member K 3
  • EC 3.1.1.13 61
  • BA186O14.2 3
  • EC 3.1.1.3 61
  • EC 3.1.1.- 4
  • Lipase K 3
  • EC 3.1.1 61

External Ids for LIPK Gene

Previous HGNC Symbols for LIPK Gene

  • LIPL2

Previous GeneCards Identifiers for LIPK Gene

  • GC10P090476
  • GC10P084118

Summaries for LIPK Gene

GeneCards Summary for LIPK Gene

LIPK (Lipase Family Member K) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPF.

UniProtKB/Swiss-Prot for LIPK Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPK Gene

Genomics for LIPK Gene

Regulatory Elements for LIPK Gene

Enhancers for LIPK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G088755 0.8 FANTOM5 10.7 +49.7 49675 0.2 PKNOX1 ZBED1 JUNB IKZF1 EED TCF7 ETV6 RELB IKZF2 CREM KRT8P38 LIPK ENSG00000201548 LIPJ RNLS LIPN
GH10G088383 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -319.1 -319128 7.4 HNRNPUL1 PKNOX1 FEZF1 YY1 GLIS2 ZNF143 KLF7 NFYC JUNB TBX21 PTEN KLLN LIPK GC10P088387 VN1R55P
GH10G088759 0.8 Ensembl ENCODE 6.2 +54.2 54204 2.3 MAX MYC ZBTB40 GABPA LIPN LIPM LIPF LIPK RCBTB2P1
GH10G088878 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +178.0 177982 10.9 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 STAMBPL1 FAS ACTA2-AS1 RPL11P3 ENSG00000201548 RNLS LIPJ LIPM LIPN ANKRD22
GH10G089206 1.2 FANTOM5 ENCODE 2.7 +501.3 501271 2.1 SIN3A ZEB1 RARA GLIS2 SCRT2 SP3 CEBPB ZNF398 ZNF610 ZNF341 FAS LIPA CH25H LIPK GC10P089210
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPK on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPK Gene

Chromosome:
10
Start:
88,706,234 bp from pter
End:
88,753,092 bp from pter
Size:
46,859 bases
Orientation:
Plus strand

Genomic View for LIPK Gene

Genes around LIPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPK Gene

Proteins for LIPK Gene

  • Protein details for LIPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXJ0-LIPK_HUMAN
    Recommended name:
    Lipase member K
    Protein Accession:
    Q5VXJ0
    Secondary Accessions:
    • A7KIH8

    Protein attributes for LIPK Gene

    Size:
    399 amino acids
    Molecular mass:
    45563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LIPK Gene

Selected DME Specific Peptides for LIPK Gene

Q5VXJ0:
  • EMAKYDLP
  • GNSRGNTW
  • VQNMLHW
  • FFALAPV
  • NLPNNSL
  • HNPAGTS

Post-translational modifications for LIPK Gene

  • Glycosylation at posLast=271271 and Asn327
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPK Gene

Gene Families for LIPK Gene

Suggested Antigen Peptide Sequences for LIPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VXJ0

UniProtKB/Swiss-Prot:

LIPK_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPK: view

Function for LIPK Gene

Molecular function for LIPK Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPK Gene

Gene Ontology (GO) - Molecular Function for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPK: view

Phenotypes for LIPK Gene

genes like me logo Genes that share phenotypes with LIPK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LIPK

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPK Gene

Localization for LIPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPK gene
Compartment Confidence
extracellular 5
lysosome 3
mitochondrion 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
genes like me logo Genes that share ontologies with LIPK: view

Pathways & Interactions for LIPK Gene

genes like me logo Genes that share pathways with LIPK: view

Interacting Proteins for LIPK Gene

Gene Ontology (GO) - Biological Process for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPK: view

No data available for SIGNOR curated interactions for LIPK Gene

Drugs & Compounds for LIPK Gene

No Compound Related Data Available

Transcripts for LIPK Gene

mRNA/cDNA for LIPK Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPK Gene

Lipase, family member K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPK Gene

No ASD Table

Relevant External Links for LIPK Gene

GeneLoc Exon Structure for
LIPK
ECgene alternative splicing isoforms for
LIPK

Expression for LIPK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPK Gene

mRNA differential expression in normal tissues according to GTEx for LIPK Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x23.8), Skin - Sun Exposed (Lower leg) (x19.4), and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for LIPK Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPK Gene



Protein tissue co-expression partners for LIPK Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPK Gene:

LIPK

SOURCE GeneReport for Unigene cluster for LIPK Gene:

Hs.632092

mRNA Expression by UniProt/SwissProt for LIPK Gene:

Q5VXJ0-LIPK_HUMAN
Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.

Evidence on tissue expression from TISSUES for LIPK Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with LIPK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPK Gene

Orthologs for LIPK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPK 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia LIPK 34 35
  • 87.21 (n)
mouse
(Mus musculus)
Mammalia Lipk 34 16 35
  • 84.59 (n)
dog
(Canis familiaris)
Mammalia LIPK 34 35
  • 83.38 (n)
rat
(Rattus norvegicus)
Mammalia Lipk 34
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005185 34
  • 45.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG18301 35
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lipl-4 35
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 35
  • 20 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16A3.12c 34
  • 47.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for LIPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPK Gene

ENSEMBL:
Gene Tree for LIPK (if available)
TreeFam:
Gene Tree for LIPK (if available)

Paralogs for LIPK Gene

Paralogs for LIPK Gene

(6) SIMAP similar genes for LIPK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPK: view

Variants for LIPK Gene

Sequence variations from dbSNP and Humsavar for LIPK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000178526 -- 88,746,126(+) CATAA(A/G)ACAAG intron-variant
rs1000206099 -- 88,746,394(+) CTCAA(C/T)AAATT intron-variant
rs1000313386 -- 88,752,488(+) AAAAC(-/TT)TTTTC intron-variant
rs1000351365 -- 88,710,827(+) ACTAC(C/T)TAAAG intron-variant
rs1000359966 -- 88,728,900(+) CCTCT(C/G)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPK Gene

Variant ID Type Subtype PubMed ID
esv1297628 CNV insertion 17803354
esv3624139 CNV gain 21293372
nsv1043015 CNV gain 25217958
nsv1052613 CNV loss 25217958
nsv551840 CNV gain 21841781
nsv831941 CNV gain 17160897

Variation tolerance for LIPK Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPK Gene

Human Gene Mutation Database (HGMD)
LIPK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPK Gene

Disorders for LIPK Gene

Relevant External Links for LIPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPK

No disorders were found for LIPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIPK Gene

Publications for LIPK Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 64

Products for LIPK Gene

Sources for LIPK Gene

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