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Aliases for LIPK Gene

Aliases for LIPK Gene

  • Lipase Family Member K 2 3
  • Lipase-Like Abhydrolase Domain-Containing Protein 2 3 4
  • Lipase-Like, Ab-Hydrolase Domain Containing 2 2 3
  • Lipase, Family Member K 3 5
  • LIPL2 3 4
  • EC 63
  • BA186O14.2 3
  • EC 63
  • EC 3.1.1.- 4
  • Lipase K 3
  • EC 3.1.1 63

External Ids for LIPK Gene

Previous HGNC Symbols for LIPK Gene

  • LIPL2

Previous GeneCards Identifiers for LIPK Gene

  • GC10P090476
  • GC10P084118

Summaries for LIPK Gene

GeneCards Summary for LIPK Gene

LIPK (Lipase Family Member K) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include hydrolase activity, acting on ester bonds. An important paralog of this gene is LIPA.

UniProtKB/Swiss-Prot for LIPK Gene

  • Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPK Gene

Genomics for LIPK Gene

Regulatory Elements for LIPK Gene

Genomic Location for LIPK Gene

88,706,234 bp from pter
88,753,092 bp from pter
46,859 bases
Plus strand

Genomic View for LIPK Gene

Genes around LIPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPK Gene

Proteins for LIPK Gene

  • Protein details for LIPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member K
    Protein Accession:
    Secondary Accessions:
    • A7KIH8

    Protein attributes for LIPK Gene

    399 amino acids
    Molecular mass:
    45563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LIPK Gene

Proteomics data for LIPK Gene at MOPED

Selected DME Specific Peptides for LIPK Gene

Post-translational modifications for LIPK Gene

  • Glycosylation at Asn 271 and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LIPK Gene

Gene Families for LIPK Gene

Suggested Antigen Peptide Sequences for LIPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPK: view

Function for LIPK Gene

Molecular function for LIPK Gene

UniProtKB/Swiss-Prot Function:
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

Enzyme Numbers (IUBMB) for LIPK Gene

Phenotypes for LIPK Gene

genes like me logo Genes that share phenotypes with LIPK: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPK Gene

Localization for LIPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPK Gene


Subcellular locations from

Jensen Localization Image for LIPK Gene COMPARTMENTS Subcellular localization image for LIPK gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
mitochondrion 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LIPK Gene

Pathways & Interactions for LIPK Gene

genes like me logo Genes that share pathways with LIPK: view

Interacting Proteins for LIPK Gene

Gene Ontology (GO) - Biological Process for LIPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPK: view

No data available for SIGNOR curated interactions for LIPK Gene

Drugs & Compounds for LIPK Gene

No Compound Related Data Available

Transcripts for LIPK Gene

mRNA/cDNA for LIPK Gene

(12) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPK Gene

Lipase, family member K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPK Gene

No ASD Table

Relevant External Links for LIPK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPK Gene

mRNA expression in normal human tissues for LIPK Gene

mRNA differential expression in normal tissues according to GTEx for LIPK Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x23.8), Skin - Sun Exposed (Lower leg) (x19.4), and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for LIPK Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPK Gene

SOURCE GeneReport for Unigene cluster for LIPK Gene Hs.632092

mRNA Expression by UniProt/SwissProt for LIPK Gene

Tissue specificity: Exclusively expressed in the epidermis within the granular keratinocytes.
genes like me logo Genes that share expression patterns with LIPK: view

Protein tissue co-expression partners for LIPK Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LIPK Gene

Orthologs for LIPK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LIPK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LIPK 35
  • 87.21 (n)
  • 84.85 (a)
  • 82 (a)
(Canis familiaris)
Mammalia LIPK 35
  • 83.38 (n)
  • 83.46 (a)
  • 73 (a)
(Mus musculus)
Mammalia Lipk 35
  • 84.59 (n)
  • 81.16 (a)
Lipk 16
Lipk 36
  • 80 (a)
(Pan troglodytes)
Mammalia LIPK 35
  • 99.58 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Lipk 35
  • 82.87 (n)
  • 81.61 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
-- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005185 35
  • 45.26 (n)
  • 36.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18301 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea lipl-4 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 36
  • 20 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16A3.12c 35
  • 47.26 (n)
  • 34.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for LIPK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPK Gene

Gene Tree for LIPK (if available)
Gene Tree for LIPK (if available)

Paralogs for LIPK Gene

Paralogs for LIPK Gene

(6) SIMAP similar genes for LIPK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPK: view

Variants for LIPK Gene

Sequence variations from dbSNP and Humsavar for LIPK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1214464 - 88,752,549(+) AAGAT(C/G)GAAGT nc-transcript-variant, reference, missense
rs17112457 - 88,752,728(+) AATTA(C/T)ATTGA downstream-variant-500B, reference, missense
rs364303 -- 88,751,125(-) GAATG(A/G)CATGC intron-variant
rs365263 -- 88,742,230(-) CCCCA(C/T)CCAAA intron-variant, downstream-variant-500B
rs365847 -- 88,752,154(-) TTCTC(C/T)TAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPK Gene

Variant ID Type Subtype PubMed ID
nsv831941 CNV Gain 17160897
esv1297628 CNV Insertion 17803354

Variation tolerance for LIPK Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.60; 86.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPK Gene

Disorders for LIPK Gene

Relevant External Links for LIPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LIPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIPK Gene

Publications for LIPK Gene

  1. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3 4 67

Products for LIPK Gene

Sources for LIPK Gene

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