Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LIPI Gene

protein-coding   GIFtS: 50
GCID: GC21M015481

Lipase, Member I

  See LIPI-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lipase, Member I1 2     Membrane-Associated Phospholipase A1 Beta DeltaE2-32
Cancer/Testis Antigen 171 2 3     Membrane-Associated Phospholipase A1 Beta DeltaE52
LPDL2 3 5     Membrane-Associated Phospholipase A1 Beta DeltaE6.12
Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta2 3     Membrane-Associated Phospholipase A1 Beta DeltaE7.22
CT172 3     Membrane-Associated Phospholipase A1 Beta DeltaE8-92
LPD Lipase2 3     Membrane-Associated Phospholipase A1 Beta Fl2
MPA-PLA1 Beta2 3     EC 3.1.1.-3
Membrane-Associated Phospholipase A1 Beta1     PRED55
PLA1C2     EC 3.1.18
Lipase Member I2     EC 3.1.1.38
Membrane-Associated Phospholipase A1 Beta 7B+2     EC 3.1.1.348

External Ids:    HGNC: 188211   Entrez Gene: 1499982   Ensembl: ENSG000001889927   OMIM: 6092525   UniProtKB: Q6XZB03   

Export aliases for LIPI gene to outside databases

Previous GC identifers: GC21M012145 GC21U900126 GC21M014407 GC21M000851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LIPI Gene:
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic
acid. The encoded protein, which can be inhibited by sodium vanadate, may be found exclusively in sperm. Defects
in this gene are a cause of susceptibility to familial hypertrigliceridemia. (provided by RefSeq, Jun 2010)

GeneCards Summary for LIPI Gene:
LIPI (lipase, member I) is a protein-coding gene. Diseases associated with LIPI include hypertriglyceridemia. GO annotations related to this gene include phospholipase activity and heparin binding. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent
bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),
phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIPI gene promoter:
         oct-B3   Lmo2   HSF1 (long)   C/EBPalpha   POU2F1   FOXJ2 (long isoform)   STAT3   HSF1short   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIPI promoter sequence
   Search Chromatin IP Primers for LIPI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11.2

LIPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPI gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M015481:  view genomic region     (about GC identifiers)

Start:
15,481,134 bp from pter      End:
15,583,166 bp from pter
Size:
102,033 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0 (See protein sequence)
Recommended Name: Lipase member I precursor  
Size: 460 amino acids; 52992 Da
Subunit: Interacts with heparin with a high affinity
Secondary accessions: G1JSG3 G1JSG4 G1JSG5 G1JSG6 G1JSG7 G1JSG8 G1JSG9
Alternative splicing: 8 isoforms:  Q6XZB0-1   Q6XZB0-2   Q6XZB0-3   Q6XZB0-4   Q6XZB0-5   Q6XZB0-6   Q6XZB0-7   Q6XZB0-8   

Explore the universe of human proteins at neXtProt for LIPI: NX_Q6XZB0

Explore proteomics data for LIPI at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn63, Asn396
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LIPI (Q6XZB0) (see all 5)
     NVIVVDW  GVSLGAH  GLDPAGP  GRITGLD 


    See LIPI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_945347.1  
    ENSEMBL proteins: 
     ENSP00000343331   ENSP00000383072   ENSP00000440381  

    LIPI Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LIPI
    GenScript Custom Purified and Recombinant Proteins Services for LIPI
    Novus Biologicals LIPI Protein
    Novus Biologicals LIPI Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIPI

     
    Search eBioscience for Proteins for LIPI 

    LIPI Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LIPI (Lipase I)
    OriGene Antibodies for LIPI
    OriGene Custom Antibody Services for LIPI
    Novus Biologicals LIPI Antibodies
    Abcam antibodies for LIPI
    Cloud-Clone Corp. Antibodies for LIPI
    ThermoFisher Antibodies for LIPI
    LSBio Antibodies in human, mouse, rat for LIPI

    LIPI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIPI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LIPI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIPI
    Cloud-Clone Corp. CLIAs for LIPI
    Search eBioscience for ELISAs for LIPI 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR013818 Lipase_N

    Graphical View of Domain Structure for InterPro Entry Q6XZB0

    ProtoNet protein and cluster: Q6XZB0

    2 Blocks protein domains:
    IPB000734 Lipase
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    Find genes that share domains with LIPI           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPI_HUMAN, Q6XZB0
    Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent
    bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),
    phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)
    Enzyme regulation: Inhibited by sodium vanadate

         Enzyme Numbers (IUBMB): EC 3.1.1.32 EC 3.1.1.342 EC 3.1.12 EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity IDA12963729
    GO:0008201heparin binding IDA12963729
         
    Find genes that share ontologies with LIPI           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lipi):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging 

    Find genes that share phenotypes with LIPI           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIPI
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIPI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIPI
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIPI

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LIPI using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LIPI:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidLIPI 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LIPI
    Predesigned siRNA for gene silencing in human, mouse, rat LIPI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIPI

    Clone
    Products:
         
    OriGene clones in human, mouse for LIPI (see all 5)
    OriGene ORF clones in mouse, rat for LIPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPI (NM_198996)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPI

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIPI
    Browse ESI BIO Cell Lines and PureStem Progenitors for LIPI 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIPI_HUMAN, Q6XZB0: Isoform 1: Membrane. Secreted. Note=May associate with lipid draft
    LIPI_HUMAN, Q6XZB0: Isoform 2: Membrane. Note=May associate with lipid draft
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    mitochondrion3
    cytosol2
    golgi apparatus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005615extracellular space IDA12963729
    GO:0005886plasma membrane IDA12963729
    GO:0016020membrane IEA--

    Find genes that share ontologies with LIPI           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIPI
    Interactions:

        Search GeneGlobe Interaction Network for LIPI

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IDA12963729

    Find genes that share ontologies with LIPI           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIPI

    Selected HMDB Compounds for LIPI (see all 23)    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LIPI gene: 
    NM_198996.2  

    Unigene Cluster for LIPI:

    Lipase, member I
    Hs.139907  [show with all ESTs]
    Unigene Representative Sequence: JN387911
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344577(uc002yjm.3) ENST00000400211 ENST00000536861(uc021whe.1 uc021whf.1 uc021whg.1 uc010gkw.2 uc021whh.1 uc021whi.1 uc021whj.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LIPI using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate LIPI:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidLIPI 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LIPI
    Predesigned siRNA for gene silencing in human, mouse, rat LIPI
    Clone
    Products:
         
    OriGene clones in human, mouse for LIPI (see all 5)
    OriGene ORF clones in mouse, rat for LIPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPI (NM_198996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPI
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LIPI
    OriGene qSTAR qPCR primer pairs in human, mouse for LIPI
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIPI
      QuantiTect SYBR Green Assays in human, mouse, rat LIPI
      QuantiFast Probe-based Assays in human, mouse, rat LIPI

    Additional mRNA sequence: 

    AY197607.1 AY918476.1 JN387910.1 JN387911.1 JN387912.1 JN387913.1 JN387914.1 JN387915.1 
    JN387916.1 

    1 DOTS entry:

    DT.95244878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LIPI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCGGCTG
    LIPI Expression
    About this image


    LIPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
    LIPI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIPI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.139907

    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
    Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm

        Custom PCR Arrays for LIPI
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LIPI
    OriGene qSTAR qPCR primer pairs in human, mouse for LIPI
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIPI
    QuantiTect SYBR Green Assays in human, mouse, rat LIPI
    QuantiFast Probe-based Assays in human, mouse, rat LIPI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LIPI gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lipi1 , 5 lipase, member I1, 5 75.98(n)1
    67.5(a)1
      16 (43.22 cM)5
    3203551  NM_001252513.11  NP_001239442.11 
     755405145 
    chicken
    (Gallus gallus)
    Aves LIPI6
    lipase, member I
    47(a)
    1 ↔ 1
    1(97342196-97364220)
    lizard
    (Anolis carolinensis)
    Reptilia LIPI6
    lipase, member I
    42(a)
    1 ↔ 1
    GL343230.1(1569855-1600153)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:919856
    lipi6
    lipase, member I
    40(a)
    37(a)
    many ↔ many
    many ↔ many
    21(33910850-33938689) ENSDARG00000007108
    24(24694439-24709080) ENSDARG00000005332
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344486
    CG101166
    (see all 30)
    --
    29(a)
    28(a)
    (see all 30)
    many ↔ many
    many ↔ many
    (see all 30)
    2L(2416809-2417965)
    3L(13449308-13450338)


    ENSEMBL Gene Tree for LIPI (if available)
    TreeFam Gene Tree for LIPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LIPI gene
    LIPH2  LIPC2  LIPG2  PNLIPRP32  PNLIPRP22  LPL2  PNLIP2  PLA1A2  
    PNLIPRP12  
    5 SIMAP similar genes for LIPI using alignment to 2 protein entries:     LIPI_HUMAN (see all proteins):
    LOC375108    LIPH    PLA1A    PNLIPRP1    PNLIPRP2

    Find genes that share paralogs with LIPI           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LIPI (see all 2595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119092171,2,,4
    C,F,Hother16120278(+) CAGCAC/TAGTTT 2 Y C mis19Minor allele frequency- T:0.01NS EA NA EU 6285
    rs352279311,2
    C--853132(+) TATTT-/GTTT  
            
    ATTTT
    1 -- int11Minor allele frequency- GTTT:0.00NA 2
    rs558278401,2
    C--855398(+) TTCTT-/G/GATT
    T
    /GATTTT
    ATTTT
    2 -- int1 cds11NA 2
    rs1475972191,2
    C--858211(+) CAGAC-/TTTTCTG 1 -- int10--------
    rs781971031,2
    C--868502(+) CGTAAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2006290471,2
    C--871451(+) ATATC-/TA    
       AA
    /TT
    AAGTG
    1 -- int10--------
    rs1424909981,2
    C--871452(+) ATCTT-/AAATC 
            
    AAGTG
    1 -- int10--------
    rs3776054581,2
    --880977(+) ATAGA-/CTAAAA 1 -- int10--------
    rs124819041,2
    C,F,H--904448(+) ttaatA/Gtataa 1 -- int11Minor allele frequency- G:0.00NA 2
    rs345819451,2
    C--917212(+) ATTTT-/AT    
       TTT
    /T
    TTAGA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for LIPI (15481134 - 15583166 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LIPI:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723174CNV Deletion23290073
    esv1678679CNV Deletion17803354
    nsv523395CNV Loss19592680
    nsv913401CNV Loss21882294
    nsv913402CNV Loss21882294
    nsv527017CNV Loss19592680
    nsv913400CNV Gain21882294

    Human Gene Mutation Database (HGMD): LIPI
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIPI
    DNA2.0 Custom Variant and Variant Library Synthesis for LIPI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609252   
    OMIM disorders: 145750  
    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the
    concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of
    heart disease, obesity, and pancreatitis. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry

  • 1 disease for LIPI:    
    About MalaCards
    hypertriglyceridemia


    Find genes that share disorders with LIPI           About GenesLikeMe


    Export disorders for LIPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LIPI gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with LIPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PubMed id 12719377)1, 2, 3, 9 Wen X.-Y.... Stewart A.K. (Hum. Mol. Genet. 2003)
    2. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PubMed id 21132378)1, 2 Schmiedel B.J.... Staege M.S. (Mol. Biol. Rep. 2011)
    3. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PubMed id 12963729)1, 2 Hiramatsu T.... Arai H. (J. Biol. Chem. 2003)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. (PubMed id 15548687)1 Staege M.S.... Burdach S.E. (Cancer Res. 2004)
    6. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PubMed id 18435455)9 Foell J.L....Staege M.S. (amp 2008)
    7. Separation and characterization of two molecular forms of Geotrichum candidum lipase. (PubMed id 2341377)9 Sugihara A....Tominaga Y. (J. Biochem. 1990)
    8. Geotrichum candidum produces several lipases with markedly different substrate specificities. (PubMed id 1761048)9 Sidebottom C.M....Slabas A.R. (Eur. J. Biochem. 1991)
    9. High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors. (PubMed id 19793082)9 Max D....Staege M.S. (Cancer Sci. 2009)
    10. Identification of residues essential for differential fatty acyl specificity of Geotrichum candidum lipases I and II. (PubMed id 9398228)9 Holmquist M....Cygler M. (Biochemistry 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 149998 HGNC: 18821 Ensembl:ENSG00000188992 euGenes: HUgn149998 ECgene: LIPI
    H-InvDB: LIPI

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LIPI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LIPI gene:
    Search GeneIP for patents involving LIPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for LIPI (Lipase I)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LIPI   OriGene RNAi products in human, mouse, rat for LIPI  
     OriGene qPCR primer pairs and template standards for LIPI   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LIPI  
     OriGene qSTAR qPCR primer pairs in human, mouse for LIPI   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LIPI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LIPI   OriGene Custom Protein Services for LIPI  

     
     
     Block miRNA regulation of human, mouse, rat LIPI using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LIPI
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIPI Predesigned siRNA for gene silencing in human, mouse, rat LIPI
     QuantiFast Probe-based Assays in human, mouse, rat LIPI QuantiTect SYBR Green Assays in human, mouse, rat LIPI
     Custom PCR Arrays for LIPI Search Chromatin IP Primers for LIPI
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIPI  Search GeneGlobe Interaction Network for LIPI
     Regulatory tfbs in LIPI promoter
     GenScript Custom Purified and Recombinant Proteins Services for LIPI GenScript cDNA clones with any tag delivered in your preferred vector for LIPI
     GenScript Custom Assay Services for LIPI GenScript Custom overexpressing Cell Line Services for LIPI
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LIPI
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LIPI antibodies
     LIPI proteins
     LIPI lysates
     Antibodies for LIPI
     See all of Abcam's Antibodies, Kits and Proteins for LIPI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LIPI
     Antibodies for LIPI
     ELISAs for LIPI
     CLIAs for LIPI



     Browse ESI BIO Cell Lines and PureStem Progenitors for LIPI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPI
     SwitchGear 3'UTR luciferase reporter plasmids for LIPI
     SwitchGear Promoter luciferase reporter plasmids for LIPI
     ThermoFisher Antibodies for LIPI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPI
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIPI
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIPI
     LSBio Antibodies in human, mouse, rat for LIPI
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LIPI
      Search eBioscience for proteins for LIPI
      Search eBioscience for elisas for LIPI
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LIPI gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4