Aliases for LIPI Gene
External Ids for LIPI Gene
Previous GeneCards Identifiers for LIPI Gene
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for LIPI Gene
LIPI (Lipase I) is a Protein Coding gene. Diseases associated with LIPI include Hypertriglyceridemia and Listeriosis. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LIPH.
UniProtKB/Swiss-Prot for LIPI Gene
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).