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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIPI Gene

protein-coding   GIFtS: 49
GCID: GC21M015481

Lipase, Member I

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lipase, Member I1 2     Membrane-Associated Phospholipase A1 Beta DeltaE2-32
Cancer/Testis Antigen 171 2 3     Membrane-Associated Phospholipase A1 Beta DeltaE52
LPDL2 3 5     Membrane-Associated Phospholipase A1 Beta DeltaE6.12
Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta2 3     Membrane-Associated Phospholipase A1 Beta DeltaE7.22
CT172 3     Membrane-Associated Phospholipase A1 Beta DeltaE8-92
LPD Lipase2 3     Membrane-Associated Phospholipase A1 Beta Fl2
MPA-PLA1 Beta2 3     EC 3.1.1.-3
Membrane-Associated Phospholipase A1 Beta1     PRED55
PLA1C2     EC 3.1.18
Lipase Member I2     EC 3.1.1.38
Membrane-Associated Phospholipase A1 Beta 7B+2     EC 3.1.1.348

External Ids:    HGNC: 188211   Entrez Gene: 1499982   Ensembl: ENSG000001889927   OMIM: 6092525   UniProtKB: Q6XZB03   

Export aliases for LIPI gene to outside databases

Previous GC identifers: GC21M012145 GC21U900126 GC21M014407 GC21M000851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIPI Gene:
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic
acid. The encoded protein, which can be inhibited by sodium vanadate, may be found exclusively in sperm. Defects
in this gene are a cause of susceptibility to familial hypertrigliceridemia. (provided by RefSeq, Jun 2010)

GeneCards Summary for LIPI Gene: 
LIPI (lipase, member I) is a protein-coding gene. Diseases associated with LIPI include familial hypertriglyceridemia, and ewing's family of tumors. GO annotations related to this gene include phospholipase activity and heparin binding. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent
bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),
phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIPI gene promoter:
         oct-B3   Lmo2   HSF1 (long)   C/EBPalpha   POU2F1   FOXJ2 (long isoform)   STAT3   HSF1short   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIPI promoter sequence
   Search SABiosciences Chromatin IP Primers for LIPI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q11.2   HGNC cytogenetic band: 21q11.2

LIPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPI gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M015481:  view genomic region     (about GC identifiers)

Start:
15,481,134 bp from pter      End:
15,583,166 bp from pter
Size:
102,033 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0 (See protein sequence)
Recommended Name: Lipase member I precursor  
Size: 460 amino acids; 52992 Da
Subunit: Interacts with heparin with a high affinity
Subcellular location: Isoform 1: Membrane. Secreted. Note=May associate with lipid draft
Subcellular location: Isoform 2: Membrane. Note=May associate with lipid draft
Alternative splicing: 2 isoforms:  Q6XZB0-1   Q6XZB0-2   

Explore the universe of human proteins at neXtProt for LIPI: NX_Q6XZB0

Explore proteomics data for LIPI at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6XZB0

  • 4/5 DME Specific Peptides for LIPI (Q6XZB0) (see all 5)
     NVIVVDW  GVSLGAH  GLDPAGP  GRITGLD 

    LIPI Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIPI Protein Expression
    REFSEQ proteins: NP_945347.1  
    ENSEMBL proteins: 
     ENSP00000343331   ENSP00000383072   ENSP00000440381  

    Human Recombinant Protein Products for LIPI: 
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    Novus Biologicals LIPI Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIPI 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005615extracellular space IDA12963729
    GO:0005886plasma membrane IDA12963729
    GO:0016020membrane IEA--

    LIPI for ontologies           About GeneDecksing



    LIPI Antibody Products: 
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    Assay Products for LIPI: 
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    Cloud-Clone Corp. CLIAs for LIPI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR013818 Lipase_N

    Graphical View of Domain Structure for InterPro Entry Q6XZB0

    ProtoNet protein and cluster: Q6XZB0

    2 Blocks protein domains:
    IPB000734 Lipase
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    LIPI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPI_HUMAN, Q6XZB0
    Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent
    bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),
    phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)
    Enzyme regulation: Inhibited by sodium vanadate

         Enzyme Numbers (IUBMB): EC 3.1.1.32 EC 3.1.1.342 EC 3.1.12 EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity IDA12963729
    GO:0008201heparin binding IDA12963729
         
    LIPI for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lipi):
     behavior/neurological  growth/size  homeostasis/metabolism  integument  liver/biliary system 
     mortality/aging 

    LIPI for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIPI 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIPI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIPI 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIPI 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIPI
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LIPI:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidLIPI 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIPI
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of LIPI 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPI


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LIPI

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016042lipid catabolic process IDA12963729

    LIPI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIPI

    10/23 HMDB Compounds for LIPI (see all 23)    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----

    Search CenterWatch for drugs/clinical trials and news about LIPI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIPI gene: 
    NM_198996.2  

    Unigene Cluster for LIPI:

    Lipase, member I
    Hs.139907  [show with all ESTs]
    Unigene Representative Sequence: JN387911
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344577(uc002yjm.3) ENST00000400211 ENST00000536861(uc021whe.1 uc021whf.1 uc021whg.1 uc010gkw.2 uc021whh.1 uc021whi.1 uc021whj.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIPI
    1 QIAGEN miScript miRNA Assays for microRNA that regulate LIPI:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidLIPI 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIPI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIPI
    Clone
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    OriGene clones in human, mouse for LIPI (see all 6)
    OriGene ORF clones in mouse, rat for LIPI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPI (NM_198996)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPI
    Sirion Biotech Customized lentivirus for stable overexpression of LIPI 
                         Customized lentivirus expression plasmids for stable overexpression of LIPI 
    Primer
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    OriGene qPCR primer pairs and template standards for LIPI
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIPI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIPI

    Additional mRNA sequence: 

    AY197607.1 AY918476.1 JN387910.1 JN387911.1 JN387912.1 JN387913.1 JN387914.1 JN387915.1 
    JN387916.1 

    1 DOTS entry:

    DT.95244878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIPI expression in normal human tissues (normalized intensities)      LIPI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTCGGCTG
    LIPI Expression
    About this image


    LIPI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate

    See LIPI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIPI

    SOURCE GeneReport for Unigene cluster: Hs.139907

    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
    Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm

        SABiosciences Custom PCR Arrays for LIPI
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIPI gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lipi1 , 5 lipase, member I1, 5 75.98(n)1
    67.5(a)1
      16 (43.22 cM)5
    3203551  NM_001252513.11  NP_001239442.11 
     755405145 
    chicken
    (Gallus gallus)
    Aves LIPI6
    lipase, member I
    47(a)
    1 ↔ 1
    1(97342196-97364220)
    lizard
    (Anolis carolinensis)
    Reptilia LIPI6
    Uncharacterized protein
    42(a)
    1 ↔ 1
    GL343230.1(1569855-1600153)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:919856
    lipi6
    lipase, member I
    40(a)
    37(a)
    many ↔ many
    many ↔ many
    21(33910850-33938689)
    24(24694439-24709080)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101166
    CG140346
    (see all 24)
    --
    28(a)
    27(a)
    (see all 24)
    possible ortholog
    possible ortholog
    (see all 24)
    3L(13449308-13450338)
    2L(5215211-5216533)


    ENSEMBL Gene Tree for LIPI (if available)
    TreeFam Gene Tree for LIPI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIPI gene
    LIPH2  LIPC2  LIPG2  PNLIPRP32  PNLIPRP22  LPL2  PNLIP2  PLA1A2  
    PNLIPRP12  
    6 SIMAP similar genes for LIPI using alignment to 9 protein entries:     LIPI_HUMAN (see all proteins):
    LOC375108    LIPH    PLA1A    PNLIPRP1    LIPG    PNLIPRP2

    LIPI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2595 SNPs in LIPI are shown (see all 2595)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119092171,2,4
    C,F,Hother16120278(+) CAGCAC/TAGTTT 2 Y C mis19Minor allele frequency- T:0.01NS EA NA EU 6285
    rs352279311,2
    C--853132(+) TATTT-/GTTT  
            
    ATTTT
    1 -- int11Minor allele frequency- GTTT:0.00NA 2
    rs558278401,2
    C--855398(+) TTCTT-/G/GATT
    T
    /GATTTT
    ATTTT
    2 -- int1 cds11NA 2
    rs1475972191,2
    C--858211(+) CAGAC-/TTTTCTG 1 -- int10--------
    rs781971031,2
    C--868502(+) CGTAAT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2006290471,2
    C--871451(+) ATATC-/TA    
       AA
    /TT
    AAGTG
    1 -- int10--------
    rs1424909981,2
    C--871452(+) ATCTT-/AAATC 
            
    AAGTG
    1 -- int10--------
    rs3776054581,2
    --880977(+) ATAGA-/CTAAAA 1 -- int10--------
    rs124819041,2
    C,F,H--904448(+) ttaatA/Gtataa 1 -- int11Minor allele frequency- G:0.00NA 2
    rs345819451,2
    C--917212(+) ATTTT-/AT    
       TTT
    /T
    TTAGA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for LIPI (15481134 - 15583166 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LIPI:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2723174CNV Deletion23290073
    esv1678679CNV Deletion17803354
    nsv523395CNV Loss19592680
    nsv913401CNV Loss21882294
    nsv913402CNV Loss21882294
    nsv527017CNV Loss19592680
    nsv913400CNV Gain21882294


    Human Gene Mutation Database (HGMD): LIPI
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LIPI
    DNA2.0 Custom Variant and Variant Library Synthesis for LIPI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609252   
    OMIM disorders: 145750  
    UniProtKB/Swiss-Prot: LIPI_HUMAN, Q6XZB0
  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the
    concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of
    heart disease, obesity, and pancreatitis. Note=Disease susceptibility is associated with variations affecting the
    gene represented in this entry

  • 6 diseases for LIPI:    About MalaCards
    familial hypertriglyceridemia    ewing's family of tumors    hypertriglyceridemia    obesity
    pancreatitis    endotheliitis


    LIPI for disorders           About GeneDecksing


    Export disorders for LIPI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIPI gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with LIPI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PubMed id 12719377)1, 2, 3, 9 Wen X.-Y.... Stewart A.K. (2003)
    2. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PubMed id 12963729)1, 2 Hiramatsu T.... Arai H. (2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    4. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PubMed id 21132378)1 Schmiedel B.J.... Staege M.S. (2011)
    5. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. (PubMed id 15548687)1 Staege M.S.... Burdach S.E. (2004)
    6. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PubMed id 18435455)9 Foell J.L....Staege M.S. (2008)
    7. Separation and characterization of two molecular forms of Geotrichum candidum lipase. (PubMed id 2341377)9 Sugihara A....Tominaga Y. (1990)
    8. Geotrichum candidum produces several lipases with markedly different substrate specificities. (PubMed id 1761048)9 Sidebottom C.M....Slabas A.R. (1991)
    9. High expression of the evolutionarily conserved alpha /beta hydrolase domain containing 6 (ABHD6) in Ewing tumors. (PubMed id 19793082)9 Max D....Staege M.S. (2009)
    10. Identification of residues essential for differential fatty acyl specificity of Geotrichum candidum lipases I and II. (PubMed id 9398228)9 Holmquist M....Cygler M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149998 HGNC: 18821 Ensembl:ENSG00000188992 euGenes: HUgn149998 ECgene: LIPI
    H-InvDB: LIPI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIPI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIPI gene:
    Search GeneIP for patents involving LIPI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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