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Aliases for LIPI Gene

Aliases for LIPI Gene

  • Lipase, Member I 2 3
  • Cancer/Testis Antigen 17 2 3 4
  • LPDL 3 4 6
  • Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta 3 4
  • MPA-PLA1 Beta 3 4
  • LPD Lipase 3 4
  • PRED5 3 6
  • CT17 3 4
  • Membrane-Associated Phospholipase A1 Beta 2
  • Lipase Member I 3
  • EC 64
  • EC 64
  • EC 3.1.1.- 4
  • EC 3.1.1 64
  • PLA1C 3

External Ids for LIPI Gene

Summaries for LIPI Gene

Entrez Gene Summary for LIPI Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for LIPI Gene

LIPI (Lipase, Member I) is a Protein Coding gene. Diseases associated with LIPI include hypertriglyceridemia and hyperlipoproteinemia type iv. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPI Gene

  • Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPI Gene

Genomics for LIPI Gene

Genomic Location for LIPI Gene

14,108,463 bp from pter
14,211,040 bp from pter
102,578 bases
Minus strand

Genomic View for LIPI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPI Gene

Regulatory Elements for LIPI Gene

Proteins for LIPI Gene

  • Protein details for LIPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member I
    Protein Accession:
    Secondary Accessions:
    • G1JSG3
    • G1JSG4
    • G1JSG5
    • G1JSG6
    • G1JSG7
    • G1JSG8
    • G1JSG9

    Protein attributes for LIPI Gene

    460 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Interacts with heparin with a high affinity

    Alternative splice isoforms for LIPI Gene

neXtProt entry for LIPI Gene

Proteomics data for LIPI Gene at MOPED

Selected DME Specific Peptides for LIPI Gene

Post-translational modifications for LIPI Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn63 and Asn396

Domains for LIPI Gene

Protein Domains for LIPI Gene


  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • Q6XZB0
genes like me logo Genes that share domains with LIPI: view

No data available for Gene Families for LIPI Gene

Function for LIPI Gene

Molecular function for LIPI Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sodium vanadate.
UniProtKB/Swiss-Prot Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Enzyme Numbers (IUBMB) for LIPI Gene

Gene Ontology (GO) - Molecular Function for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IDA 12963729
GO:0008201 heparin binding IDA 12963729
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPI: view
genes like me logo Genes that share phenotypes with LIPI: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LIPI Gene

Localization for LIPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPI Gene

Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.
Isoform 2: Membrane. Note=May associate with lipid draft.

Subcellular locations from

Jensen Localization Image for LIPI Gene COMPARTMENTS Subcellular localization image for LIPI gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 12963729
GO:0005886 plasma membrane IDA 12963729
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LIPI: view

Pathways for LIPI Gene

SuperPathways for LIPI Gene

No Data Available

Interacting Proteins for LIPI Gene

Gene Ontology (GO) - Biological Process for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0016042 lipid catabolic process IDA 12963729
genes like me logo Genes that share ontologies with LIPI: view

No data available for Pathways by source for LIPI Gene

Compounds for LIPI Gene

(23) HMDB Compounds for LIPI Gene

Compound Synonyms Cas Number PubMed IDs
  • Lysophosphatidic acid(16:0)
Not Available
  • 2-octadecanoyl-phosphatidic acid
Not Available
  • LPA(18:1)
Not Available
  • LPA(0:0/18:2n6)
Not Available
  • Lysophosphatidic acid(16:0/0:0)
Not Available
genes like me logo Genes that share compounds with LIPI: view

Transcripts for LIPI Gene

mRNA/cDNA for LIPI Gene

Unigene Clusters for LIPI Gene

Lipase, member I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPI Gene

No ASD Table

Relevant External Links for LIPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPI Gene

mRNA expression in normal human tissues for LIPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPI Gene

This gene is overexpressed in Colon - Sigmoid (6.9), Thyroid (6.6), and Uterus (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LIPI Gene

SOURCE GeneReport for Unigene cluster for LIPI Gene Hs.139907

mRNA Expression by UniProt/SwissProt for LIPI Gene

Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
genes like me logo Genes that share expressions with LIPI: view

Orthologs for LIPI Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIPI 36
  • 99.1 (n)
  • 98.75 (a)
  • 99 (a)
(Bos Taurus)
Mammalia LIPI 37
  • 68 (a)
(Canis familiaris)
Mammalia LIPI 36
  • 84.62 (n)
  • 76.92 (a)
  • 75 (a)
(Mus musculus)
Mammalia Lipi 36
  • 75.98 (n)
  • 67.5 (a)
Lipi 16
(Ornithorhynchus anatinus)
Mammalia LIPI 37
  • 48 (a)
(Rattus norvegicus)
Mammalia Lipi 36
  • 75.91 (n)
  • 64.77 (a)
(Gallus gallus)
Aves LIPI 37
  • 47 (a)
(Anolis carolinensis)
Reptilia LIPI 37
  • 42 (a)
(Danio rerio)
Actinopterygii lipi 37
  • 37 (a)
zgc:91985 37
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10116 37
  • 28 (a)
CG10357 37
  • 27 (a)
CG13282 37
  • 20 (a)
CG14034 37
  • 27 (a)
CG17191 37
  • 24 (a)
CG17192 37
  • 23 (a)
CG17292 37
  • 24 (a)
CG18258 37
  • 18 (a)
CG18641 37
  • 23 (a)
CG1986 37
  • 25 (a)
CG34447 37
  • 27 (a)
CG34448 37
  • 29 (a)
CG4267 37
  • 22 (a)
CG4582 37
  • 20 (a)
CG5162 37
  • 22 (a)
CG5665 37
  • 23 (a)
CG6271 37
  • 24 (a)
CG6277 37
  • 24 (a)
CG6283 37
  • 25 (a)
CG6295 37
  • 26 (a)
CG6296 37
  • 14 (a)
CG6431 37
  • 23 (a)
CG6472 37
  • 27 (a)
CG6675 37
  • 22 (a)
CG6847 37
  • 16 (a)
CG7367 37
  • 24 (a)
sxe2 37
  • 24 (a)
Yp1 37
  • 16 (a)
Yp2 37
  • 16 (a)
Yp3 37
  • 16 (a)
Species with no ortholog for LIPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPI Gene

Gene Tree for LIPI (if available)
Gene Tree for LIPI (if available)

Paralogs for LIPI Gene

Paralogs for LIPI Gene

Selected SIMAP similar genes for LIPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPI: view

Variants for LIPI Gene

Sequence variations from dbSNP and Humsavar for LIPI Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs52931 -- 14,198,880(-) ttttg(C/T)tttgc intron-variant
rs52932 -- 14,198,851(-) caatt(A/C)tgtgt intron-variant
rs118511 -- 14,208,433(-) GTAGA(A/T)TAATT upstream-variant-2KB, intron-variant
rs118512 -- 14,208,013(-) AACAA(A/G)GATCA upstream-variant-2KB, intron-variant
rs366677 -- 14,200,611(-) GTGTG(A/C/T)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPI Gene

Variant ID Type Subtype PubMed ID
nsv527017 CNV Loss 19592680
nsv913400 CNV Gain 21882294
nsv913401 CNV Loss 21882294
esv1678679 CNV Deletion 17803354
nsv913402 CNV Loss 21882294
nsv523395 CNV Loss 19592680
esv2723174 CNV Deletion 23290073

Relevant External Links for LIPI Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for LIPI Gene

(1) OMIM Diseases for LIPI Gene (609252)


  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with LIPI: view

Publications for LIPI Gene

  1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PMID: 12719377) Wen X.-Y. … Stewart A.K. (Hum. Mol. Genet. 2003) 2 3 4 23
  2. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PMID: 18435455) Foell J.L. … Staege M.S. (Pediatr Blood Cancer 2008) 3 23
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PMID: 12963729) Hiramatsu T. … Arai H. (J. Biol. Chem. 2003) 3 4
  5. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PMID: 21132378) Schmiedel B.J. … Staege M.S. (Mol. Biol. Rep. 2011) 3 4

Products for LIPI Gene

Sources for LIPI Gene

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