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Aliases for LIPI Gene

Aliases for LIPI Gene

  • Lipase I 2 3
  • Cancer/Testis Antigen 17 2 3 4
  • Lipase, Member I 2 3 5
  • Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta 3 4
  • MPA-PLA1 Beta 3 4
  • LPD Lipase 3 4
  • CT17 3 4
  • LPDL 3 4
  • Membrane-Associated Phospholipase A1 Beta 2
  • EC 3.1.1.34 63
  • EC 3.1.1.3 63
  • EC 3.1.1.- 4
  • EC 3.1.1 63
  • PLA1C 3
  • PRED5 3

External Ids for LIPI Gene

Previous GeneCards Identifiers for LIPI Gene

  • GC21M012145
  • GC21U900126
  • GC21M014407
  • GC21M015481
  • GC21M000851

Summaries for LIPI Gene

Entrez Gene Summary for LIPI Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for LIPI Gene

LIPI (Lipase I) is a Protein Coding gene. Diseases associated with LIPI include hypertriglyceridemia and hyperlipoproteinemia type iv. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPI Gene

  • Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPI Gene

Genomics for LIPI Gene

Regulatory Elements for LIPI Gene

Genomic Location for LIPI Gene

Chromosome:
21
Start:
14,108,463 bp from pter
End:
14,211,040 bp from pter
Size:
102,578 bases
Orientation:
Minus strand

Genomic View for LIPI Gene

Genes around LIPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPI Gene

Proteins for LIPI Gene

  • Protein details for LIPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XZB0-LIPI_HUMAN
    Recommended name:
    Lipase member I
    Protein Accession:
    Q6XZB0
    Secondary Accessions:
    • G1JSG3
    • G1JSG4
    • G1JSG5
    • G1JSG6
    • G1JSG7
    • G1JSG8
    • G1JSG9

    Protein attributes for LIPI Gene

    Size:
    460 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Interacts with heparin with a high affinity.

    Alternative splice isoforms for LIPI Gene

neXtProt entry for LIPI Gene

Proteomics data for LIPI Gene at MOPED

Selected DME Specific Peptides for LIPI Gene

Post-translational modifications for LIPI Gene

  • Glycosylation at Asn 63 and Asn 396
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for LIPI Gene

Gene Families for LIPI Gene

Protein Domains for LIPI Gene

Suggested Antigen Peptide Sequences for LIPI Gene

Graphical View of Domain Structure for InterPro Entry

Q6XZB0

UniProtKB/Swiss-Prot:

LIPI_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPI: view

Function for LIPI Gene

Molecular function for LIPI Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium vanadate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Enzyme Numbers (IUBMB) for LIPI Gene

Gene Ontology (GO) - Molecular Function for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPI: view
genes like me logo Genes that share phenotypes with LIPI: view

Human Phenotype Ontology for LIPI Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPI Gene

Localization for LIPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPI Gene

Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.
Isoform 2: Membrane. Note=May associate with lipid draft.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPI Gene COMPARTMENTS Subcellular localization image for LIPI gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LIPI: view

Pathways & Interactions for LIPI Gene

genes like me logo Genes that share pathways with LIPI: view

Interacting Proteins for LIPI Gene

Gene Ontology (GO) - Biological Process for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPI: view

No data available for SIGNOR curated interactions for LIPI Gene

Drugs & Compounds for LIPI Gene

(23) Additional Compounds for LIPI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with LIPI: view

Transcripts for LIPI Gene

mRNA/cDNA for LIPI Gene

(8) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPI Gene

Lipase, member I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPI Gene

No ASD Table

Relevant External Links for LIPI Gene

GeneLoc Exon Structure for
LIPI
ECgene alternative splicing isoforms for
LIPI

Expression for LIPI Gene

mRNA expression in normal human tissues for LIPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPI Gene

This gene is overexpressed in Colon - Sigmoid (x6.9), Thyroid (x6.6), and Uterus (x4.6).

Protein differential expression in normal tissues from HIPED for LIPI Gene

This gene is overexpressed in Prostate (49.8) and Adipocyte (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPI Gene



SOURCE GeneReport for Unigene cluster for LIPI Gene Hs.139907

mRNA Expression by UniProt/SwissProt for LIPI Gene

Q6XZB0-LIPI_HUMAN
Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
genes like me logo Genes that share expression patterns with LIPI: view

Protein tissue co-expression partners for LIPI Gene

Primer Products

In Situ Assay Products

Orthologs for LIPI Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPI Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LIPI 35
  • 84.62 (n)
  • 76.92 (a)
LIPI 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lipi 35
  • 75.98 (n)
  • 67.5 (a)
Lipi 16
chimpanzee
(Pan troglodytes)
Mammalia LIPI 35
  • 99.1 (n)
  • 98.75 (a)
LIPI 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lipi 35
  • 75.91 (n)
  • 64.77 (a)
cow
(Bos Taurus)
Mammalia LIPI 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIPI 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIPI 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIPI 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lipi 36
  • 37 (a)
ManyToMany
zgc:91985 36
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10116 36
  • 28 (a)
ManyToMany
CG10357 36
  • 27 (a)
ManyToMany
CG13282 36
  • 20 (a)
ManyToMany
CG14034 36
  • 27 (a)
ManyToMany
CG17191 36
  • 24 (a)
ManyToMany
CG17192 36
  • 23 (a)
ManyToMany
CG17292 36
  • 24 (a)
ManyToMany
CG18258 36
  • 18 (a)
ManyToMany
CG18641 36
  • 23 (a)
ManyToMany
CG1986 36
  • 25 (a)
ManyToMany
CG34447 36
  • 27 (a)
ManyToMany
CG34448 36
  • 29 (a)
ManyToMany
CG4267 36
  • 22 (a)
ManyToMany
CG4582 36
  • 20 (a)
ManyToMany
CG5162 36
  • 22 (a)
ManyToMany
CG5665 36
  • 23 (a)
ManyToMany
CG6271 36
  • 24 (a)
ManyToMany
CG6277 36
  • 24 (a)
ManyToMany
CG6283 36
  • 25 (a)
ManyToMany
CG6295 36
  • 26 (a)
ManyToMany
CG6296 36
  • 14 (a)
ManyToMany
CG6431 36
  • 23 (a)
ManyToMany
CG6472 36
  • 27 (a)
ManyToMany
CG6675 36
  • 22 (a)
ManyToMany
CG6847 36
  • 16 (a)
ManyToMany
CG7367 36
  • 24 (a)
ManyToMany
sxe2 36
  • 24 (a)
ManyToMany
Yp1 36
  • 16 (a)
ManyToMany
Yp2 36
  • 16 (a)
ManyToMany
Yp3 36
  • 16 (a)
ManyToMany
Species with no ortholog for LIPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPI Gene

ENSEMBL:
Gene Tree for LIPI (if available)
TreeFam:
Gene Tree for LIPI (if available)

Paralogs for LIPI Gene

Paralogs for LIPI Gene

(5) SIMAP similar genes for LIPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPI: view

Variants for LIPI Gene

Sequence variations from dbSNP and Humsavar for LIPI Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs11909217 Hypertriglyceridemia, familial (FHTR) 14,189,302(+) CAGCA(C/T)AGTTT reference, missense
rs74369337 - 14,152,600(+) TCATT(A/C/T)CAAGC intron-variant, reference, missense
rs2822432 - 14,144,627(+) CCTTT(C/T)TGGGT intron-variant, reference, missense
rs7278737 - 14,109,044(+) TCTCT(G/T)TCTTT reference, missense
rs52931 -- 14,198,880(-) ttttg(C/T)tttgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPI Gene

Variant ID Type Subtype PubMed ID
nsv527017 CNV Loss 19592680
nsv913400 CNV Gain 21882294
nsv913401 CNV Loss 21882294
esv1678679 CNV Deletion 17803354
nsv913402 CNV Loss 21882294
nsv523395 CNV Loss 19592680
esv2723174 CNV Deletion 23290073

Variation tolerance for LIPI Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.93; 94.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPI Gene

HapMap Linkage Disequilibrium report
LIPI
Human Gene Mutation Database (HGMD)
LIPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPI Gene

Disorders for LIPI Gene

MalaCards: The human disease database

(3) MalaCards diseases for LIPI Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypertriglyceridemia
  • familial hypertriglyceridemia
hyperlipoproteinemia type iv
  • familial hypertriglyceridemia
listeriosis
  • infection by listeria monocytogenes
- elite association - COSMIC cancer census association via MalaCards
Search LIPI in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIPI_HUMAN
  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. {ECO:0000269 PubMed:12719377}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for LIPI

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPI
genes like me logo Genes that share disorders with LIPI: view

No data available for Genatlas for LIPI Gene

Publications for LIPI Gene

  1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PMID: 12719377) Wen X.-Y. … Stewart A.K. (Hum. Mol. Genet. 2003) 2 3 4 23 67
  2. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PMID: 18435455) Foell J.L. … Staege M.S. (Pediatr Blood Cancer 2008) 3 23
  3. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. (PMID: 23611148) Willier S. … Grunewald T.G. (Biol. Cell 2013) 3
  4. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PMID: 21132378) Schmiedel B.J. … Staege M.S. (Mol. Biol. Rep. 2011) 3
  5. High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors. (PMID: 19793082) Max D. … Staege M.S. (Cancer Sci. 2009) 23

Products for LIPI Gene

Sources for LIPI Gene

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