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Aliases for LIPI Gene

Aliases for LIPI Gene

  • Lipase I 2 3 5
  • Cancer/Testis Antigen 17 2 3 4
  • Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Beta 3 4
  • Lipase, Member I 2 3
  • MPA-PLA1 Beta 3 4
  • LPD Lipase 3 4
  • CT17 3 4
  • LPDL 3 4
  • Membrane-Associated Phospholipase A1 Beta 2
  • Lipase Member I 3
  • EC 61
  • EC 61
  • EC 3.1.1.- 4
  • EC 3.1.1 61
  • PLA1C 3
  • PRED5 3

External Ids for LIPI Gene

Previous GeneCards Identifiers for LIPI Gene

  • GC21M012145
  • GC21U900126
  • GC21M014407
  • GC21M015481
  • GC21M000851

Summaries for LIPI Gene

Entrez Gene Summary for LIPI Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for LIPI Gene

LIPI (Lipase I) is a Protein Coding gene. Diseases associated with LIPI include Hypertriglyceridemia and Listeriosis. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot for LIPI Gene

  • Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPI Gene

Genomics for LIPI Gene

Regulatory Elements for LIPI Gene

Enhancers for LIPI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F014381 1.1 ENCODE 11.3 -172.3 -172259 3.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 LIPI HSPA13 LOC105369304
GH21F014026 0.9 ENCODE 4.6 +183.2 183205 2.2 TBP HDAC1 ATF1 PKNOX1 SIN3A ZBTB40 RARA ELK1 FOS SP3 ANKRD20A18P RHOT1P2 ENSG00000224905 LIPI
GH21F014225 0.3 FANTOM5 10.6 -14.3 -14314 0.1 RBM11 ABCC13 LIPI
GH21F014479 0.3 FANTOM5 2.3 -268.3 -268253 0.1 SAMSN1 LIPI HSPA13 SAMSN1-AS1
GH21F014115 0.9 Ensembl ENCODE 0.1 +94.7 94714 1.1 HDGF PKNOX1 MTA2 EBF1 TBX21 ATF2 IKZF1 TARDBP NBN IRF1 ENSG00000224905 ERLEC1P1 LIPI
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPI on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPI Gene

14,108,463 bp from pter
14,211,040 bp from pter
102,578 bases
Minus strand

Genomic View for LIPI Gene

Genes around LIPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPI Gene

Proteins for LIPI Gene

  • Protein details for LIPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipase member I
    Protein Accession:
    Secondary Accessions:
    • G1JSG3
    • G1JSG4
    • G1JSG5
    • G1JSG6
    • G1JSG7
    • G1JSG8
    • G1JSG9

    Protein attributes for LIPI Gene

    460 amino acids
    Molecular mass:
    52992 Da
    Quaternary structure:
    • Interacts with heparin with a high affinity.

    Alternative splice isoforms for LIPI Gene

neXtProt entry for LIPI Gene

Selected DME Specific Peptides for LIPI Gene


Post-translational modifications for LIPI Gene

  • Glycosylation at Asn 63 and Asn 396
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPI Gene

Gene Families for LIPI Gene

Suggested Antigen Peptide Sequences for LIPI Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPI: view

Function for LIPI Gene

Molecular function for LIPI Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sodium vanadate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

Enzyme Numbers (IUBMB) for LIPI Gene

Gene Ontology (GO) - Molecular Function for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity TAS --
GO:0008201 heparin binding IEA,IDA 12963729
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPI: view
genes like me logo Genes that share phenotypes with LIPI: view

Human Phenotype Ontology for LIPI Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPI Gene

MGI Knock Outs for LIPI:
  • Lipi tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for LIPI Gene

Localization for LIPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPI Gene

Isoform 1: Membrane. Secreted. Note=May associate with lipid draft.
Isoform 2: Membrane. Note=May associate with lipid draft.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPI gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LIPI: view

Pathways & Interactions for LIPI Gene

genes like me logo Genes that share pathways with LIPI: view

Interacting Proteins for LIPI Gene

Selected Interacting proteins: Q6XZB0-LIPI_HUMAN for LIPI Gene via IID

Gene Ontology (GO) - Biological Process for LIPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA,IDA 12963729
GO:0044241 lipid digestion TAS --
genes like me logo Genes that share ontologies with LIPI: view

No data available for SIGNOR curated interactions for LIPI Gene

Drugs & Compounds for LIPI Gene

(23) Additional Compounds for LIPI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with LIPI: view

Transcripts for LIPI Gene

mRNA/cDNA for LIPI Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIPI Gene

Lipase, member I:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPI Gene

No ASD Table

Relevant External Links for LIPI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPI Gene

This gene is overexpressed in Colon - Sigmoid (x6.9), Thyroid (x6.6), and Uterus (x4.6).

Protein differential expression in normal tissues from HIPED for LIPI Gene

This gene is overexpressed in Prostate (49.8) and Adipocyte (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LIPI Gene

Protein tissue co-expression partners for LIPI Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPI Gene:


SOURCE GeneReport for Unigene cluster for LIPI Gene:


mRNA Expression by UniProt/SwissProt for LIPI Gene:

Tissue specificity: Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
genes like me logo Genes that share expression patterns with LIPI: view

Primer Products

Orthologs for LIPI Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIPI 34 35
  • 99.1 (n)
(Canis familiaris)
Mammalia LIPI 34 35
  • 84.62 (n)
(Mus musculus)
Mammalia Lipi 34 16
  • 75.98 (n)
(Rattus norvegicus)
Mammalia Lipi 34
  • 75.91 (n)
(Bos Taurus)
Mammalia LIPI 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia LIPI 35
  • 48 (a)
(Gallus gallus)
Aves LIPI 35
  • 47 (a)
(Anolis carolinensis)
Reptilia LIPI 35
  • 42 (a)
(Danio rerio)
Actinopterygii zgc:91985 35
  • 40 (a)
lipi 35
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34448 35
  • 29 (a)
CG10116 35
  • 28 (a)
CG10357 35
  • 27 (a)
CG14034 35
  • 27 (a)
CG34447 35
  • 27 (a)
CG6472 35
  • 27 (a)
CG6295 35
  • 26 (a)
CG1986 35
  • 25 (a)
CG6283 35
  • 25 (a)
CG17191 35
  • 24 (a)
CG17292 35
  • 24 (a)
CG6271 35
  • 24 (a)
CG6277 35
  • 24 (a)
CG7367 35
  • 24 (a)
sxe2 35
  • 24 (a)
CG17192 35
  • 23 (a)
CG18641 35
  • 23 (a)
CG5665 35
  • 23 (a)
CG6431 35
  • 23 (a)
CG4267 35
  • 22 (a)
CG5162 35
  • 22 (a)
CG6675 35
  • 22 (a)
CG13282 35
  • 20 (a)
CG4582 35
  • 20 (a)
CG18258 35
  • 18 (a)
CG6847 35
  • 16 (a)
Yp1 35
  • 16 (a)
Yp2 35
  • 16 (a)
Yp3 35
  • 16 (a)
CG6296 35
  • 14 (a)
Species where no ortholog for LIPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPI Gene

Gene Tree for LIPI (if available)
Gene Tree for LIPI (if available)

Paralogs for LIPI Gene

Paralogs for LIPI Gene

(5) SIMAP similar genes for LIPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIPI: view

Variants for LIPI Gene

Sequence variations from dbSNP and Humsavar for LIPI Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs11909217 Hypertriglyceridemia, familial (FHTR) [MIM:145750], other 14,189,302(+) CAGCA(C/T)AGTTT reference, missense
rs10432766 -- 14,108,895(+) CTTGA(A/G)TCTCA utr-variant-3-prime
rs10470080 -- 14,176,527(+) atatt(A/G)tttat intron-variant
rs10553728 -- 14,207,464(+) AAGAT(-/AGTC)AGCAA intron-variant, upstream-variant-2KB
rs10854283 -- 14,124,824(+) CATCT(C/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPI Gene

Variant ID Type Subtype PubMed ID
dgv4385n100 CNV gain 25217958
esv1678679 CNV deletion 17803354
esv2723174 CNV deletion 23290073
esv3575380 CNV gain 25503493
esv3646422 CNV gain 21293372
esv3893371 CNV gain 25118596
esv3893372 CNV loss 25118596
nsv1056787 CNV loss 25217958
nsv1058072 CNV gain 25217958
nsv1058202 CNV loss 25217958
nsv1143254 CNV deletion 24896259
nsv523395 CNV loss 19592680
nsv527017 CNV loss 19592680
nsv587043 CNV loss 21841781

Variation tolerance for LIPI Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.93; 94.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPI Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPI Gene

Disorders for LIPI Gene

MalaCards: The human disease database

(2) MalaCards diseases for LIPI Gene - From: OMIM, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • familial hypertriglyceridemia
  • infection by listeria monocytogenes
- elite association - COSMIC cancer census association via MalaCards
Search LIPI in MalaCards View complete list of genes associated with diseases


  • Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. {ECO:0000269 PubMed:12719377}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for LIPI

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LIPI: view

No data available for Genatlas for LIPI Gene

Publications for LIPI Gene

  1. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PMID: 12719377) Wen X.-Y. … Stewart A.K. (Hum. Mol. Genet. 2003) 2 3 4 22 64
  2. Expression of multiple membrane-associated phospholipase A1 beta transcript variants and lysophosphatidic acid receptors in Ewing tumor cells. (PMID: 21132378) Schmiedel B.J. … Staege M.S. (Mol. Biol. Rep. 2011) 3 4 64
  3. Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen. (PMID: 18435455) Foell J.L. … Staege M.S. (Pediatr Blood Cancer 2008) 3 22 64
  4. Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PMID: 12963729) Hiramatsu T. … Arai H. (J. Biol. Chem. 2003) 3 4 64
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64

Products for LIPI Gene

Sources for LIPI Gene

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