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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LIPH Gene

protein-coding GIFtS: 51
GCID: GC03M185224

lipase, member H

Explore 11 diseases affiliated with
LIPH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lipase, Member H¹ ²		MPA-PLA1alpha¹
LPDLR¹ ² ³		AH²
PLA1B¹ ² ³		Lipase H²
MPA-PLA1¹		Lipase Member H²
Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Alpha² ³		Membrane-Bound Phosphatidic Acid-Selective Phospholipase A1²
Phospholipase A1 Member B² ³		EC 3.1.1.-³
LPD Lipase-Related Protein² ³		MPAPLA1³
MPA-PLA1 Alpha² ³		EC 3.1.1⁸
ARWH2² ⁵		EC 3.1.1.3⁸
LAH2² ⁵

External Ids:	HGNC: 18483¹	Entrez Gene: 200879²	Ensembl: ENSG00000163898⁷	OMIM: 607365⁵	UniProtKB: Q8WWY8³

Export aliases for LIPH gene to outside databases

Previous GC identifers: GC03M182017 GC03M186408 GC03M186627 GC03M186546 GC03M186708 GC03M182635

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIPH:

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of

2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet

aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: LIPH_HUMAN, Q8WWY8

Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent

bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),

phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)

Gene Wiki entry for LIPH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for LIPH
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LIPH promoter sequence

Search SABiosciences Chromatin IP Primers for LIPH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIPH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27 Ensembl cytogenetic band: 3q27.2 HGNC cytogenetic band: 3q27

LIPH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPH gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M185224: view genomic region (about GC identifiers)

Start:	185,224,050 bp from pter	End:	185,270,401 bp from pter
Size:	46,352 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIPH_HUMAN, Q8WWY8 (See protein sequence)

Recommended Name: Lipase member H precursor

Size: 451 amino acids; 50859 Da

Subcellular location: Secreted. Membrane; Peripheral membrane protein

Sequence caution: Sequence=BAB85023.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A2IBA7 Q8TEC7

Explore the universe of human proteins at neXtProt for LIPH: NX_Q8WWY8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WWY8

4/7 DME Specific Peptides for LIPH (Q8WWY8) (see all 7)

GVSLGAH

RLDPSDA

YFKCDHQ

GLDPAGP

LIPH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_640341.1

ENSEMBL proteins:

ENSP00000296252 ENSP00000396384 ENSP00000390228 ENSP00000408218 ENSP00000414311

Human Recombinant Protein Products for LIPH:

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	Novus Biologicals LIPH Proteins Novus Biologicals LIPH Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LIPH

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IDA	12963729
GO:0005886	plasma membrane	IDA	12963729

LIPH for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LIPH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LIPH for domains About GeneDecksing

3 InterPro domains/families:

IPR000734 Lipase

IPR016272 Lipoprotein_lipase_LIPH

IPR013818 Lipase_N

Graphical View of Domain Structure for InterPro Entry Q8WWY8

ProtoNet protein and cluster: Q8WWY8

1 Blocks protein family: IPB000734 Lipase

UniProtKB/Swiss-Prot: LIPH_HUMAN, Q8WWY8

Similarity: Belongs to the AB hydrolase superfamily. Lipase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LIPH_HUMAN, Q8WWY8

Function: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent

bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS),

phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG)

Enzyme regulation: Inhibited by sodium vanadate

Enzyme Numbers (IUBMB): EC 3.1.1.3² EC 3.1.1² EC 3.1.1.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004620	phospholipase activity	IDA	12963729
GO:0008201	heparin binding	IDA	12963729
GO:0016787	hydrolase activity	--	--

LIPH for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Liph):

integument

pigmentation

LIPH for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Liph^tm1Aoki for LIPH

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LIPH

miRNA Products:		OriGene 3'-UTR Clone: LIPH Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIPH
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate LIPH (see all 23):
		hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-138-2* hsa-let-7g hsa-let-7a hsa-miR-489

		SwitchGear 3'UTR luciferase reporter plasmid: LIPH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPH

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LIPH

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for LIPH (ENSP00000296252⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0016042	lipid catabolic process	IDA	12963729

LIPH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LIPH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LIPH

10/23 HMDB Compounds for LIPH (see all 23) About this table

Compound	Synonyms	CAS #	PubMed Ids
LPA(0:0/16:0)	Lysophosphatidic acid(16:0) (see all 6)	--	--
LPA(0:0/18:0)	2-octadecanoyl-phosphatidic acid (see all 6)	--	--
LPA(0:0/18:1(9Z))	LPA(18:1) (see all 10)	--	--
LPA(0:0/18:2(9Z,12Z))	LPA(0:0/18:2n6) (see all 10)	--	--
LPA(16:0/0:0)	Lysophosphatidic acid(16:0/0:0) (see all 14)	--	--
LPA(18:0/0:0)	1-octadecanoyl-phosphatidic acid (see all 6)	--	--
LPA(18:0e/0:0)	[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)	--	--
LPA(18:1(9Z)/0:0)	1-oleoyl-glycero-3-phosphate (see all 26)	--	--
LPA(18:2(9Z,12Z)/0:0)	LPA(18:2w6/0:0) (see all 10)	--	--
LPA(P-16:0e/0:0)	1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e)	--	--

1 Novoseek chemical compound relationship for LIPH gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	16	4	19818411 (2), 12213196 (1), 19536142 (1)

Search CenterWatch for drugs/clinical trials and news about LIPH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LIPH gene:

NM_139248.2

Unigene Cluster for LIPH:

Lipase, member H

Hs.68864 [show with all ESTs]

Unigene Representative Sequence: NM_139248

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296252(uc003fpm.3 uc010hyh.3) ENST00000424591 ENST00000435679

ENST00000452897 ENST00000429510

miRNA Products:		OriGene 3'-UTR Clone: LIPH Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIPH
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate LIPH (see all 23):
		hsa-miR-345 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-138-2* hsa-let-7g hsa-let-7a hsa-miR-489

		SwitchGear 3'UTR luciferase reporter plasmid: LIPH 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LIPH (see all 7) OriGene shRNA RFP: LIPH OriGene siRNA: LIPH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIPH
		Sirion Biotech Custom design and validation of potent shRNA sequences against LIPH

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		GenScript: all cDNA clones in your preferred vector: LIPH (NM_139248)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIPH

Additional cDNA sequence:

AK074229.1 AK122651.1 AK298380.1 AY036912.1 AY093498.1 BC064941.1 EF186228.1 EF186229.1

4 DOTS entries:

DT.40114985 DT.101979127 DT.409410 DT.95119720

24/43 AceView cDNA sequences (see all 43):

AI732452 AI733889 AI424922 CK904038 BX490362 AW518939 BI966144 BF063937

AA132946 AA367368 BC064941 BU175585 AK074229 AK122651 AA149791 BI965988

AI732595 BF677759 BG697821 AI420906 AY036912 AY093498 BM839230 NM_139248

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for LIPH About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b
SP1:							-
SP2:							-				-		-		-
SP3:
SP4:																									-

ECgene alternative splicing isoforms for LIPH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LIPH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCAAGGGA

About this image

LIPH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LIPH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIPH

SOURCE GeneReport for Unigene cluster: Hs.68864

UniProtKB/Swiss-Prot: LIPH_HUMAN, Q8WWY8

Tissue specificity: Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary,

testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently

expressed in hair follicles, including the stem cell-rich bulge region

SABiosciences Custom PCR Arrays for LIPH

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIPH

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LIPH gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LIPH¹	lipase, member H	66.59(n) 63.18(a)		424874 XM_422687.3 XP_422687.3
lizard (Anolis carolinensis)	Reptilia	LIPI⁶	--	59(a)	1 ↔ 1	GL343230.1(1571713-1600153)
African clawed frog (Xenopus laevis)	Amphibia	MGC68721²	hypothetical protein MGC68721	72.13(n)		BC060482.1
zebrafish (Danio rerio)	Actinopterygii	wufb08f08²	Transcribed sequence with weak similarity to protein more	80.23(n)		CK018413.1
fruit fly (Drosophila melanogaster)	Insecta	CG10357⁶ CG34448⁶ (see all 30)	--	25(a) 24(a) (see all 30)	many ↔ many many ↔ many (see all 30)	3L(3615382-3616682) 2L(2416809-2417965)

ENSEMBL Gene Tree for LIPH (if available)
TreeFam Gene Tree for LIPH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LIPH gene

LIPI² LIPC² PLA1A² LIPG² PNLIPRP1² PNLIPRP3² LPL² PNLIP²

9 SIMAP similar genes for LIPH using alignment to 6 protein entries: LIPH_HUMAN (see all proteins):

LIPC LIPI PNLIPRP3 LOC375108 PNLIPRP1 LIPG

PLA1A PNLIPRP2 PNLIP

LIPH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113893264^1,2	C	--	182635130(+)	`TGTTCC/GAAAAG`	1	--	ds500¹		0	--	--	--	--
rs1048823^1,2	C	--	182635344(-)	`AGGCAA/GGGGAA`	1	--	ut3¹ trp³		3		MN NA	188
rs115973917^1,2	C,F	--	182635778(+)	`TGGCAC/TGGAGA`	1	--	ut3¹		1		WA	118
rs55854644^1,2	C,F	--	182636087(+)	`TCTGCC/TTTGCA`	1	--	ut3¹		2		NA EA	240
rs112875244^1,2	C	--	182636782(+)	`CAAGGC/AGGGTG`	1	--	int¹		1		WA	2
rs74666847^1,2	C	--	182637282(+)	`AACTTG/ATACTA`	1	--	int¹		1		WA	2
rs78611656^1,2	F	--	182639694(+)	`AAATCC/TAGAGT`	1	--	int¹		1		WA	118
rs13099109^1,2	H	--	182640275(+)	`ATAAAA/CCTAAT`	1	--	int¹		3		EA NS	292
rs13079105^1,2	H	--	182640277(+)	`AAAACT/AAATCT`	1	--	int¹		3		EA NS	286
rs13099262^1,2	H	--	182640293(+)	`gtgccC/Tagatt`	1	--	int¹		3		EA NS	300

HapMap Linkage Disequilibrium report for LIPH (185224050 - 185270401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LIPH: --
Human Gene Mutation Database (HGMD): LIPH

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIPH

DNA2.0 Custom Variant and Variant Library Synthesis for LIPH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LIPH for disorders           About GeneDecksing

OMIM gene information: 607365
OMIM disorders: 604379
UniProtKB/Swiss-Prot: LIPH_HUMAN, Q8WWY8

Defects in LIPH are the cause of hypotrichosis type 7 (HYPT7) [MIM:604379]; also known as alopecia universalis

congenita Mari type. A condition characterized by the presence of less than the normal amount of hair. Affected

individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes

Defects in LIPH are the cause of woolly hair autosomal recessive type 2 (ARWH2) [MIM:604379]. A hair shaft

disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some

populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows

some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with

hypotrichosis

11 diseases for LIPH: About MalaCards

woolly hair, autosomal recessive 2 with or without hypotrichosis woolly hair, autosomal recessive hypotrichosis, localized, autosomal recessive 2 hypotrichosis

alopecia universalis hypotrichosis simplex monilethrix alopecia

hypertriglyceridemia pancreatitis prostatitis

3 diseases from the University of Copenhagen DISEASES database for LIPH:

Hypotrichosis Myofascial pain syndrome Monilethrix

Export disorders for LIPH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LIPH gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with LIPH)

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Lipase h, a new member of the triglyceride lipase family synthesized by the intestine. (PubMed id 12213196)^{1, 2, 3, 9} Jin W.... Rader D. (2002)
A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. (PubMed id 12063250)^{1, 2, 3, 9} Sonoda H.... Arai H. (2002)
Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH. (PubMed id 17095700)^{1, 2, 9} Kazantseva A.... Rogaev E.I. (2006)
Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2). (PubMed id 19167195)^{1, 2, 9} Naz G.... Ahmad W. (2009)
Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. (PubMed id 18830268)^{1, 2, 9} Shimomura Y....Christiano A.M. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. (PubMed id 12719377)^{1, 2} Wen X.-Y.... Stewart A.K. (2003)
Biochemical and molecular characterization of two phosphatidic acid- selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta. (PubMed id 12963729)^{1, 2} Hiramatsu T.... Arai H. (2003)
In vitro analysis of LIPH mutations causing hypotrich osis simplex: evidence confirming the role of lipase H and lysophosphatidic aci d in hair growth. (PubMed id 19536142)^{1, 9} Pasternack S.M....Betz R.C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 200879	HGNC: 18483	AceView: LIPH	Ensembl:ENSG00000163898	euGenes: HUgn200879
ECgene: LIPH	H-InvDB: LIPH

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LIPH	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LIPH gene
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Patent Information for LIPH gene:
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LIPH Gene

lipase, member H

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LIPH (Gene Symbol)
Lipase, Member H
LPDLR
PLA1B
MPA-PLA1
Membrane-Associated Phosphatidic Acid-Selective Phospholipase A1-Alpha
Phospholipase A1 Member B
LPD Lipase-Related Protein
MPA-PLA1 Alpha
ARWH2
LAH2
MPA-PLA1alpha
AH
Lipase H
Lipase Member H
Membrane-Bound Phosphatidic Acid-Selective Phospholipase A1
EC 3.1.1.-
MPAPLA1
EC 3.1.1
EC 3.1.1.3

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LIPH Gene

lipase, member H

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