Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LIPG Gene

protein-coding   GIFtS: 63
GCID: GC18P047088

Lipase, Endothelial

  See LIPG-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lipase, Endothelial1 2     PRO7192
EDL2 3 5     Endothelial Lipase2
EL2 3 5     Lipoprotein Lipase H2
Endothelial Cell-Derived Lipase2 3     EC 3.1.18
EC 3.1.1.33 8     

External Ids:    HGNC: 66231   Entrez Gene: 93882   Ensembl: ENSG000001016707   OMIM: 6036845   UniProtKB: Q9Y5X93   

Export aliases for LIPG gene to outside databases

Previous GC identifers: GC18P047247 GC18P046887 GC18P045340 GC18P045342 GC18P043942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LIPG Gene:
The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein
metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and
characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LIPG Gene:
LIPG (lipase, endothelial) is a protein-coding gene. Diseases associated with LIPG include hyperalphalipoproteinemia. GO annotations related to this gene include phospholipase activity and heparin binding. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot: LIPE_HUMAN, Q9Y5X9
Function: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more
efficiently than other lipoproteins. Binds heparin

summary for LIPG Gene:
Endothelial lipase (LIPG) is a vascular lipase which is synthesized in endothelial cells. LIPG hydrolyzes
the phospholipids of VLDL, chylomicrons and HDL; it also displays triglyceride lipase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIPG gene promoter:
         PPAR-alpha   PPAR-gamma1   MyoD   CUTL1   Nkx2-5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIPG promoter sequence
   Search Chromatin IP Primers for LIPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

LIPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPG gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P047088:  view genomic region     (about GC identifiers)

Start:
47,087,069 bp from pter      End:
47,119,278 bp from pter
Size:
32,210 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIPE_HUMAN, Q9Y5X9 (See protein sequence)
Recommended Name: Endothelial lipase precursor  
Size: 500 amino acids; 56795 Da
Subunit: Head to tail homodimer
Miscellaneous: It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a
characteristic that distinguishes it from other members of the family. However, this protein is also expressed in
other cell types
Secondary accessions: B0LPG6 Q6P9C8 Q6UW82
Alternative splicing: 2 isoforms:  Q9Y5X9-1   Q9Y5X9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIPG: NX_Q9Y5X9

Explore proteomics data for LIPG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn80, Asn136, Asn393, Asn469, Asn491
  • Selected DME Specific Peptides for LIPG (Q9Y5X9) (see all 8)
     RLSPDDA  KMYLKTR  GLDPAGP  GRITGLD 


    See LIPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006024.1  
    ENSEMBL proteins: 
     ENSP00000463835   ENSP00000463077   ENSP00000261292   ENSP00000387978   ENSP00000462420  
     ENSP00000462480  

    LIPG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LIPG
    OriGene Protein Over-expression Lysate for LIPG
    OriGene MassSpec for LIPG
    OriGene Custom Protein Services for LIPG
    GenScript Custom Purified and Recombinant Proteins Services for LIPG
    Novus Biologicals LIPG Proteins
    Novus Biologicals LIPG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIPG

     
    Search eBioscience for Proteins for LIPG 

    LIPG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LIPG
    OriGene Custom Antibody Services for LIPG
    Novus Biologicals LIPG Antibodies
    Abcam antibodies for LIPG
    Cloud-Clone Corp. Antibodies for LIPG
    ThermoFisher Antibodies for LIPG
    LSBio Antibodies in human, mouse, rat for LIPG

    LIPG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIPG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LIPG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIPG
    Cloud-Clone Corp. CLIAs for LIPG
    Search eBioscience for ELISAs for LIPG 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR013818 Lipase_N

    Graphical View of Domain Structure for InterPro Entry Q9Y5X9

    ProtoNet protein and cluster: Q9Y5X9

    4 Blocks protein domains:
    IPB000734 Lipase
    IPB001024 Lipoxygenase
    IPB002330 Lipoprotein lipase signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPE_HUMAN, Q9Y5X9
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family
    Similarity: Contains 1 PLAT domain


    Find genes that share domains with LIPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPE_HUMAN, Q9Y5X9
    Function: Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more
    efficiently than other lipoproteins. Binds heparin
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
    Enzyme regulation: Inhibited by serum

         Enzyme Numbers (IUBMB): EC 3.1.1.31 2 EC 3.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004465lipoprotein lipase activity IEA--
    GO:0004620phospholipase activity IDA10192396
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
    GO:0008970phosphatidylcholine 1-acylhydrolase activity IDA10318835
         
    Find genes that share ontologies with LIPG           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for LIPG:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased circadian period len  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lipg):
     cardiovascular system  homeostasis/metabolism 

    Find genes that share phenotypes with LIPG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LIPG: Lipgtm1Lex Lipgtm1Tq Lipgtm1Chan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIPG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIPG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIPG

    miRNA
    Products:
        
    miRTarBase miRNAs that target LIPG:
    hsa-mir-335-5p (MIRT017862)

    Block miRNA regulation of human, mouse, rat LIPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIPG (see all 16):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-539 hsa-miR-300 hsa-miR-1271 hsa-miR-218 hsa-miR-4267 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidLIPG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LIPG
    Predesigned siRNA for gene silencing in human, mouse, rat LIPG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIPG

    Clone
    Products:
         
    OriGene clones in human, mouse for LIPG (see all 6)
    OriGene ORF clones in mouse, rat for LIPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPG (NM_006033)
    Sino Biological Human cDNA Clone for LIPG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIPG
    Browse ESI BIO Cell Lines and PureStem Progenitors for LIPG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIPE_HUMAN, Q9Y5X9: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA10192396

    Find genes that share ontologies with LIPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LIPG About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2triacylglycerol degradation
    triacylglycerol degradation
    3Glycerolipid metabolism
    Glycerolipid metabolism


    Find genes that share SuperPaths with LIPG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LIPG
        triacylglycerol degradation



    2 Kegg Pathways  (Kegg details for LIPG):
        Glycerolipid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIPG
    Interactions:

        GeneGlobe Interaction Network for LIPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LIPG (Q9Y5X93 ENSP000002612924) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC5Q9NQT43, ENSP000002212334I2D: score=2 STRING: ENSP00000221233
    FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
    CELENSP000003611514STRING: ENSP00000361151
    DGAT1ENSP000003322584STRING: ENSP00000332258
    DGAT2ENSP000002280274STRING: ENSP00000228027
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS10192396
    GO:0007584response to nutrient IEA--
    GO:0008283cell proliferation IEA--
    GO:0009395phospholipid catabolic process NAS19136670
    GO:0010983positive regulation of high-density lipoprotein particle clearance IMP19136670

    Find genes that share ontologies with LIPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for LIPG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JZL 184Monoacylglycerol lipase (MAGL) inhibitor[1101854-58-3]
    Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]
    Pristimerin Potent, reversible MAGL inhibitor [1258-84-0]
    GSK 264220AEndothelial lipase and lipoprotein lipase inhibitor[685506-42-7]

    Selected HMDB Compounds for LIPG (see all 1142)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    Selected Novoseek inferred chemical compound relationships for LIPG gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-palmitoyl-2-arachidonyl-phosphatidylcholine 88.2 3 14622025 (2)
    phospholipid 63.9 29 14594995 (3), 17110602 (2), 15017361 (1), 16877778 (1) (see all 17)
    cholesterol 63.8 87 18988890 (5), 15664301 (4), 14984737 (3), 15080796 (3) (see all 31)
    lysophosphatidylcholine 54.8 1 18988890 (1)
    lipid 53.4 32 10872808 (2), 19818411 (2), 7952914 (1), 12213196 (1) (see all 21)
    triacylglycerol 51.9 13 15080796 (2), 18433755 (1), 16039280 (1), 18537717 (1) (see all 6)
    p-opc 42.1 1 15687350 (1)
    fatty acid 26.3 7 12553881 (2), 17905648 (1), 16843334 (1), 18070364 (1)
    phosphatidylcholine 22.9 10 15834125 (4), 18288265 (1), 18988890 (1)
    asparagine 17.1 9 17545692 (2), 15342690 (1)



    Find genes that share compounds with LIPG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LIPG gene: 
    NM_006033.2  

    Unigene Cluster for LIPG:

    Lipase, endothelial
    Hs.465102  [show with all ESTs]
    Unigene Representative Sequence: BC060825
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577628 ENST00000583083 ENST00000261292(uc002ldv.3 uc010xdh.2)
    ENST00000427224 ENST00000580036(uc002ldu.1) ENST00000579750
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LIPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIPG (see all 16):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-539 hsa-miR-300 hsa-miR-1271 hsa-miR-218 hsa-miR-4267 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidLIPG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LIPG
    Predesigned siRNA for gene silencing in human, mouse, rat LIPG
    Clone
    Products:
         
    OriGene clones in human, mouse for LIPG (see all 6)
    OriGene ORF clones in mouse, rat for LIPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPG (NM_006033)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPG
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LIPG
    OriGene qSTAR qPCR primer pairs in human, mouse for LIPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIPG
      QuantiTect SYBR Green Assays in human, mouse, rat LIPG
      QuantiFast Probe-based Assays in human, mouse, rat LIPG

    Additional mRNA sequence: 

    AF118767.1 AK125344.1 AK291799.1 AK300333.1 AK315252.1 AY358928.1 BC060825.1 

    7 DOTS entries:

    DT.308029  DT.100640620  DT.70102945  DT.101961360  DT.101968472  DT.95340609  DT.91681808 

    Selected AceView cDNA sequences (see all 89):

    BM668887 AF118767 AW594725 AW235402 BX482946 AK124636 BX459178 CR610175 
    AI651337 AW450414 AI743209 AW769138 AK125344 AI971073 BM762604 BE502020 
    BF195630 AI684302 BM129722 T17270 NM_006033 BC060825 BQ010834 AY358928 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LIPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGTGGTA
    LIPG Expression
    About this image


    LIPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
    LIPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465102

    UniProtKB/Swiss-Prot: LIPE_HUMAN, Q9Y5X9
    Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the
    corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells
    and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle

        Custom PCR Arrays for LIPG
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LIPG
    OriGene qSTAR qPCR primer pairs in human, mouse for LIPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIPG
    QuantiTect SYBR Green Assays in human, mouse, rat LIPG
    QuantiFast Probe-based Assays in human, mouse, rat LIPG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LIPG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lipg1 , 5 lipase, endothelial1, 5 81.9(n)1
    80.36(a)1
      18 (50.94 cM)5
    168911  NM_010720.31  NP_034850.31 
     749393225 
    chicken
    (Gallus gallus)
    Aves LIPG1 lipase, endothelial 70.18(n)
    73.26(a)
      426846  XM_424455.4  XP_424455.4 
    lizard
    (Anolis carolinensis)
    Reptilia LIPG6
    lipase, endothelial
    73(a)
    1 ↔ 1
    2(117884-133256)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691062 hypothetical protein MGC69106 73.21(n)    BC060756.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553452 similar to lipase, endothelial 73.37(n)   393096  BC044146.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62773 triacylglycerol lipase 37(a)
    (best of 3)
      97D14   --


    ENSEMBL Gene Tree for LIPG (if available)
    TreeFam Gene Tree for LIPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LIPG gene
    LIPH2  LIPC2  PNLIPRP32  PNLIPRP22  LPL2  PNLIP2  LIPI2  PLA1A2  
    PNLIPRP12  
    7 SIMAP similar genes for LIPG using alignment to 4 protein entries:     LIPE_HUMAN (see all proteins):
    LPL    LIPH    LIPC    PNLIPRP1    PLA1A    PNLIP
    PNLIPRP2

    Find genes that share paralogs with LIPG           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LIPG
    PGOHUM00000263000


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LIPG (see all 853)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821175991,2
    --47086460(+) TATGAA/GCAACT 1 -- us2k10--------
    rs1866730671,2
    --47086538(+) TTGCAA/GCCCTG 1 -- us2k10--------
    rs617671561,2
    C,F--47086556(+) GGGCTC/GAAGGA 1 -- us2k15Minor allele frequency- G:0.10NS NA WA 560
    rs1491624741,2
    --47086631(+) TAATTA/TAAAAA 1 -- us2k10--------
    rs1433080821,2
    --47086721(+) GCCACC/TAGACC 1 -- us2k10--------
    rs1483454781,2
    --47086758(+) GTCAAC/TTGGCC 1 -- us2k10--------
    rs1117266311,2
    C,F--47086794(+) AGACCC/TGGTTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1405629351,2
    --47086840(+) ATGACC/TCAGTT 1 -- us2k10--------
    rs99589471,2
    C,F,A,H--47086932(+) ATATCT/CGGGGG 1 -- us2k127Minor allele frequency- C:0.22NS EA NA WA CSA 2717
    rs1122018781,2
    C--47086940(-) AAATAC/TCACCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LIPG (47087069 - 47119278 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LIPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1216550CNV Deletion17803354
    nsv438288CNV Loss16468122

    Human Gene Mutation Database (HGMD): LIPG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIPG
    DNA2.0 Custom Variant and Variant Library Synthesis for LIPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603684    OMIM disorders: --

    1 disease for LIPG:    
    About MalaCards
    hyperalphalipoproteinemia

    1 disease from the University of Copenhagen DISEASES database for LIPG:
    Atherosclerosis

    Find genes that share disorders with LIPG           About GenesLikeMe

    9 Novoseek inferred disease relationships for LIPG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 54.8 25 15664301 (4), 16354105 (3), 15304490 (2), 15023297 (1) (see all 15)
    dyslipidemia 34.8 1 17495604 (1)
    cardiovascular diseases 34.5 7 16498510 (2), 20031622 (1), 18612200 (1), 19058966 (1)
    inflammation 22.6 30 16980590 (4), 18612200 (3), 18537717 (3), 18212282 (3) (see all 12)
    coronary heart disease 20.8 3 7952914 (1), 19411665 (1), 18212282 (1)
    obesity 16.9 5 16772345 (2), 17495604 (1), 16980590 (1), 18212282 (1)
    vascular diseases 11.2 4 10872808 (2), 10318835 (1), 15914124 (1)
    necrosis 5.59 5 18212282 (2), 17093291 (1), 18612200 (1), 15973764 (1)
    tumors 0 6 18212282 (2), 17093291 (1), 18612200 (1), 19082487 (1) (see all 5)

    Genetic Association Database (GAD): LIPG
    Human Genome Epidemiology (HuGE) Navigator: LIPG (40 documents)

    Export disorders for LIPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LIPG gene, integrated from 10 sources (see all 178):
    (articles sorted by number of sources associating them with LIPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a unique lipase from endothelial cells extends the lipase gene family. (PubMed id 10318835)1, 2, 3, 9 Hirata K.... Quertermous T. (J. Biol. Chem. 1999)
    2. A novel endothelial-derived lipase that modulates HDL metabolism. (PubMed id 10192396)1, 2, 3 Jaye M.... Rader D.J. (Nat. Genet. 1999)
    3. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (PubMed id 19287092)1, 4, 9 Edmondson A.C....Rader D.J. (J. Clin. Invest. 2009)
    4. Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children. (PubMed id 12884003)1, 4, 9 Yamakawa-Kobayashi K....Hamaguchi H. (Hum. Genet. 2003)
    5. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. (PubMed id 19380136)1, 4, 9 Smith C.E....OrdovA!s J.M. (Atherosclerosis 2009)
    6. The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women. (PubMed id 12867537)1, 4, 9 Paradis M.E....Lamarche B. (J. Lipid Res. 2003)
    7. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. (PubMed id 19411665)1, 4, 9 Jensen M.K....Overvad K. (Eur. Heart J. 2009)
    8. [The -384A &gt;C polymorphism of endothelial lipase gene promoter region in Chinese healthy normolipidemic and endogenous hypertriglyceridemic subjects]. (PubMed id 18683147)1, 4, 9 Huang Y....Liu B.W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    9. Higher order lipase gene association with plasma triglycerides. (PubMed id 15961789)1, 4, 9 Reilly M.P....Rader D.J. (J. Lipid Res. 2005)
    10. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)1, 4, 9 Willer C.J....Abecasis G.R. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9388 HGNC: 6623 AceView: LIPG Ensembl:ENSG00000101670 euGenes: HUgn9388
    ECgene: LIPG Kegg: 9388 H-InvDB: LIPG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LIPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LIPG gene:
    Search GeneIP for patents involving LIPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LIPG   OriGene RNAi products in human, mouse, rat for LIPG  
     OriGene qPCR primer pairs and template standards for LIPG   OriGene Protein Over-expression Lysate for LIPG  
     OriGene MassSpec something-or-other for LIPG   OriGene clones in human, mouse for LIPG  
     OriGene qSTAR qPCR primer pairs in human, mouse for LIPG   OriGene Purified Protein for LIPG  
     OriGene ORF clones in mouse, rat for LIPG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LIPG   OriGene Custom Protein Services for LIPG  

     
     
     Block miRNA regulation of human, mouse, rat LIPG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LIPG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIPG Predesigned siRNA for gene silencing in human, mouse, rat LIPG
     QuantiFast Probe-based Assays in human, mouse, rat LIPG QuantiTect SYBR Green Assays in human, mouse, rat LIPG
     Custom PCR Arrays for LIPG Search Chromatin IP Primers for LIPG
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIPG  GeneGlobe Interaction Network for LIPG
     Regulatory tfbs in LIPG promoter
     GenScript Custom Purified and Recombinant Proteins Services for LIPG GenScript cDNA clones with any tag delivered in your preferred vector for LIPG
     GenScript Custom Assay Services for LIPG GenScript Custom overexpressing Cell Line Services for LIPG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for LIPG
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for LIPG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LIPG antibodies
     LIPG proteins
     LIPG lysates
     Antibodies for LIPG
     See all of Abcam's Antibodies, Kits and Proteins for LIPG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LIPG
     Antibodies for LIPG
     ELISAs for LIPG
     CLIAs for LIPG



     Browse ESI BIO Cell Lines and PureStem Progenitors for LIPG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPG
     SwitchGear 3'UTR luciferase reporter plasmids for LIPG
     SwitchGear Promoter luciferase reporter plasmids for LIPG
     ThermoFisher Antibodies for LIPG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIPG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIPG
     LSBio Antibodies in human, mouse, rat for LIPG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LIPG
      Search eBioscience for proteins for LIPG
      Search eBioscience for elisas for LIPG
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LIPG gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4