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Aliases for LIPG Gene

Aliases for LIPG Gene

  • Lipase G, Endothelial Type 2 3
  • Lipase, Endothelial 2 3 5
  • Endothelial Cell-Derived Lipase 3 4
  • EC 3.1.1.3 4 63
  • EDL 3 4
  • EL 3 4
  • Lipoprotein Lipase H 3
  • EC 3.1.1 63
  • PRO719 3

External Ids for LIPG Gene

Previous GeneCards Identifiers for LIPG Gene

  • GC18P047247
  • GC18P046887
  • GC18P045340
  • GC18P045342
  • GC18P047088
  • GC18P043942

Summaries for LIPG Gene

Entrez Gene Summary for LIPG Gene

  • The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPG Gene

LIPG (Lipase G, Endothelial Type) is a Protein Coding gene. Diseases associated with LIPG include gastric leiomyoma and wolman disease. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPG Gene

  • Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Tocris Summary for LIPG Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPG Gene

Genomics for LIPG Gene

Regulatory Elements for LIPG Gene

Promoters for LIPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIPG on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPG Gene

Chromosome:
18
Start:
49,560,699 bp from pter
End:
49,599,182 bp from pter
Size:
38,484 bases
Orientation:
Plus strand

Genomic View for LIPG Gene

Genes around LIPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPG Gene

Proteins for LIPG Gene

  • Protein details for LIPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X9-LIPE_HUMAN
    Recommended name:
    Endothelial lipase
    Protein Accession:
    Q9Y5X9
    Secondary Accessions:
    • B0LPG6
    • Q6P9C8
    • Q6UW82

    Protein attributes for LIPG Gene

    Size:
    500 amino acids
    Molecular mass:
    56795 Da
    Quaternary structure:
    • Head to tail homodimer.
    Miscellaneous:
    • It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

    Alternative splice isoforms for LIPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPG Gene

Proteomics data for LIPG Gene at MOPED

Selected DME Specific Peptides for LIPG Gene

Post-translational modifications for LIPG Gene

  • Glycosylation at Asn 80, Asn 136, Asn 393, Asn 469, and Asn 491
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPG Gene

Domains & Families for LIPG Gene

Gene Families for LIPG Gene

Suggested Antigen Peptide Sequences for LIPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5X9

UniProtKB/Swiss-Prot:

LIPE_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPG: view

Function for LIPG Gene

Molecular function for LIPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serum.
UniProtKB/Swiss-Prot Function:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Enzyme Numbers (IUBMB) for LIPG Gene

Gene Ontology (GO) - Molecular Function for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008201 heparin binding IEA --
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IDA 10318835
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with LIPG: view
genes like me logo Genes that share phenotypes with LIPG: view

Animal Models for LIPG Gene

MGI Knock Outs for LIPG:

Animal Model Products

miRNA for LIPG Gene

miRTarBase miRNAs that target LIPG

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIPG Gene

Localization for LIPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPG Gene COMPARTMENTS Subcellular localization image for LIPG gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with LIPG: view

Pathways & Interactions for LIPG Gene

genes like me logo Genes that share pathways with LIPG: view

Pathways by source for LIPG Gene

Gene Ontology (GO) - Biological Process for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0008283 cell proliferation IEA --
GO:0009395 phospholipid catabolic process NAS 19136670
GO:0032376 positive regulation of cholesterol transport IDA 19136670
GO:0042632 cholesterol homeostasis IMP 19136670
genes like me logo Genes that share ontologies with LIPG: view

No data available for SIGNOR curated interactions for LIPG Gene

Drugs & Compounds for LIPG Gene

(13) Drugs for LIPG Gene - From: Novoseek, HMDB, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(23) Additional Compounds for LIPG Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with LIPG: view

Transcripts for LIPG Gene

Unigene Clusters for LIPG Gene

Lipase, endothelial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPG Gene

No ASD Table

Relevant External Links for LIPG Gene

GeneLoc Exon Structure for
LIPG
ECgene alternative splicing isoforms for
LIPG

Expression for LIPG Gene

mRNA expression in normal human tissues for LIPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPG Gene

This gene is overexpressed in Thyroid (x25.3) and Liver (x10.6).

Protein differential expression in normal tissues from HIPED for LIPG Gene

This gene is overexpressed in Placenta (39.7) and Prostate (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIPG Gene



SOURCE GeneReport for Unigene cluster for LIPG Gene Hs.465102

mRNA Expression by UniProt/SwissProt for LIPG Gene

Q9Y5X9-LIPE_HUMAN
Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.
genes like me logo Genes that share expression patterns with LIPG: view

Protein tissue co-expression partners for LIPG Gene

Primer Products

In Situ Assay Products

Orthologs for LIPG Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPG 36
  • 100 (a)
OneToOne
LIPG 35
  • 99.47 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia LOC509808 35
  • 84.65 (n)
  • 83.02 (a)
dog
(Canis familiaris)
Mammalia LIPG 35
  • 85.53 (n)
  • 86 (a)
LIPG 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lipg 36
  • 80 (a)
OneToOne
Lipg 16
Lipg 35
  • 81.9 (n)
  • 80.36 (a)
oppossum
(Monodelphis domestica)
Mammalia LIPG 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lipg 35
  • 81.06 (n)
  • 79.84 (a)
chicken
(Gallus gallus)
Aves LIPG 35
  • 70.18 (n)
  • 73.26 (a)
LIPG 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIPG 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69106 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lipg 35
  • 66.53 (n)
  • 66.6 (a)
zebrafish
(Danio rerio)
Actinopterygii lipg 36
  • 58 (a)
OneToOne
lipg 35
  • 62.63 (n)
  • 62 (a)
zgc55345 35
fruit fly
(Drosophila melanogaster)
Insecta CG6271 37
  • 37 (a)
CG6277 37
  • 37 (a)
CG6472 37
  • 34 (a)
CG5966 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
Species with no ortholog for LIPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPG Gene

ENSEMBL:
Gene Tree for LIPG (if available)
TreeFam:
Gene Tree for LIPG (if available)

Paralogs for LIPG Gene

Paralogs for LIPG Gene

(7) SIMAP similar genes for LIPG Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LIPG Gene

genes like me logo Genes that share paralogs with LIPG: view

Variants for LIPG Gene

Sequence variations from dbSNP and Humsavar for LIPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_017027 -
rs2000813 - 49,567,494(+) GCACA(C/T)AAGAG reference, missense
VAR_017029 -
rs9963243 - 49,562,384(+) CTTTT(A/G)GTCCA intron-variant, reference, missense
rs1320699 -- 49,569,608(+) CTCCC(A/C)AATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPG Gene

Variant ID Type Subtype PubMed ID
nsv438288 CNV Loss 16468122
esv1216550 CNV Deletion 17803354

Variation tolerance for LIPG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPG Gene

HapMap Linkage Disequilibrium report
LIPG
Human Gene Mutation Database (HGMD)
LIPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPG Gene

Disorders for LIPG Gene

MalaCards: The human disease database

(3) MalaCards diseases for LIPG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric leiomyoma
  • leiomyoma of the stomach
wolman disease
  • cholesteryl ester storage disease
hyperalphalipoproteinemia
  • cholesterol-ester transfer protein deficiency
- elite association - COSMIC cancer census association via MalaCards
Search LIPG in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPG

Genetic Association Database (GAD)
LIPG
Human Genome Epidemiology (HuGE) Navigator
LIPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPG
genes like me logo Genes that share disorders with LIPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPG Gene

Publications for LIPG Gene

  1. Cloning of a unique lipase from endothelial cells extends the lipase gene family. (PMID: 10318835) Hirata K. … Quertermous T. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms. (PMID: 19780863) Nielsen J.E. … Rajpert-De Meyts E. (Int. J. Androl. 2010) 3 23
  3. Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages. (PMID: 18988890) Qiu G. … Hill J.S. (Arterioscler. Thromb. Vasc. Biol. 2009) 3 23
  4. Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase. (PMID: 19136670) Nijstad N. … Tietge U.J. (J. Biol. Chem. 2009) 3 23
  5. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (PMID: 19287092) Edmondson A.C. … Rader D.J. (J. Clin. Invest. 2009) 3 23

Products for LIPG Gene

Sources for LIPG Gene

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