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Aliases for LIPG Gene

Aliases for LIPG Gene

  • Lipase, Endothelial 2 3
  • EDL 3 4 6
  • El 3 4 6
  • Endothelial Cell-Derived Lipase 3 4
  • EC 4 63
  • Lipoprotein Lipase H 3
  • Endothelial Lipase 3
  • EC 3.1.1 63
  • PRO719 3

External Ids for LIPG Gene

Previous GeneCards Identifiers for LIPG Gene

  • GC18P047247
  • GC18P046887
  • GC18P045340
  • GC18P045342
  • GC18P047088
  • GC18P043942

Summaries for LIPG Gene

Entrez Gene Summary for LIPG Gene

  • The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPG Gene

LIPG (Lipase, Endothelial) is a Protein Coding gene. Diseases associated with LIPG include hyperalphalipoproteinemia. Among its related pathways are Metabolism and Glycerolipid metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPG Gene

  • Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin

Tocris Summary for LIPG Gene

  • Endothelial lipase (LIPG) is a vascular lipase which is synthesized in endothelial cells. LIPG hydrolyzes the phospholipids of VLDL, chylomicrons and HDL; it also displays triglyceride lipase activity.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPG Gene

Genomics for LIPG Gene

Regulatory Elements for LIPG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LIPG Gene

49,560,699 bp from pter
49,599,182 bp from pter
38,484 bases
Plus strand

Genomic View for LIPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPG Gene

Proteins for LIPG Gene

  • Protein details for LIPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endothelial lipase
    Protein Accession:
    Secondary Accessions:
    • B0LPG6
    • Q6P9C8
    • Q6UW82

    Protein attributes for LIPG Gene

    500 amino acids
    Molecular mass:
    56795 Da
    Quaternary structure:
    • Head to tail homodimer.
    • It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types

    Alternative splice isoforms for LIPG Gene


neXtProt entry for LIPG Gene

Proteomics data for LIPG Gene at MOPED

Selected DME Specific Peptides for LIPG Gene

Post-translational modifications for LIPG Gene

  • Glycosylation at Asn80, Asn136, Asn393, Asn469, and Asn491
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPG Gene

Domains for LIPG Gene

Suggested Antigen Peptide Sequences for LIPG Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5X9
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPG: view

No data available for Gene Families for LIPG Gene

Function for LIPG Gene

Molecular function for LIPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serum
UniProtKB/Swiss-Prot Function:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin

Enzyme Numbers (IUBMB) for LIPG Gene

Gene Ontology (GO) - Molecular Function for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity IEA --
GO:0004620 phospholipase activity IDA 10192396
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IDA 10318835
genes like me logo Genes that share ontologies with LIPG: view
genes like me logo Genes that share phenotypes with LIPG: view

Animal Models for LIPG Gene

MGI Knock Outs for LIPG:

Animal Model Products

miRNA for LIPG Gene

miRTarBase miRNAs that target LIPG

No data available for Transcription Factor Targeting and HOMER Transcription for LIPG Gene

Localization for LIPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPG Gene


Subcellular locations from

Jensen Localization Image for LIPG Gene COMPARTMENTS Subcellular localization image for LIPG gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 10192396
GO:0005769 early endosome IDA 23918928
GO:0005794 Golgi apparatus IDA 23918928
GO:0009986 cell surface IDA 23918928
genes like me logo Genes that share ontologies with LIPG: view

Pathways for LIPG Gene

genes like me logo Genes that share pathways with LIPG: view

Pathways by source for LIPG Gene

1 BioSystems pathway for LIPG Gene
2 KEGG pathways for LIPG Gene

Gene Ontology (GO) - Biological Process for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10192396
GO:0007584 response to nutrient IEA --
GO:0008283 cell proliferation IEA --
GO:0009395 phospholipid catabolic process NAS 19136670
GO:0010983 positive regulation of high-density lipoprotein particle clearance IMP 19136670
genes like me logo Genes that share ontologies with LIPG: view

Compounds for LIPG Gene

(2) Tocris Compounds for LIPG Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor [685506-42-7]
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]

(1142) HMDB Compounds for LIPG Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
  • DAG(14:0/14:0)
Not Available
  • DAG(14:0/14:1)
Not Available
  • Diacylglycerol(29:0)
Not Available

(14) Novoseek inferred chemical compound relationships for LIPG Gene

Compound -log(P) Hits PubMed IDs
1-palmitoyl-2-arachidonyl-phosphatidylcholine 88.2 2
phospholipid 63.9 20
cholesterol 63.8 51
lysophosphatidylcholine 54.8 1
lipid 53.4 23
genes like me logo Genes that share compounds with LIPG: view

Transcripts for LIPG Gene

Unigene Clusters for LIPG Gene

Lipase, endothelial:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIPG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPG Gene

No ASD Table

Relevant External Links for LIPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPG Gene

mRNA expression in normal human tissues for LIPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPG Gene

This gene is overexpressed in Thyroid (25.3) and Liver (10.6).

Protein differential expression in normal tissues for LIPG Gene

This gene is overexpressed in Placenta (39.7) and Prostate (29.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIPG Gene

SOURCE GeneReport for Unigene cluster for LIPG Gene Hs.465102

mRNA Expression by UniProt/SwissProt for LIPG Gene

Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle
genes like me logo Genes that share expressions with LIPG: view

Expression partners for LIPG Gene

In Situ Assay Products

Orthologs for LIPG Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC509808 35
  • 84.65 (n)
  • 83.02 (a)
(Canis familiaris)
Mammalia LIPG 35
  • 85.53 (n)
  • 86 (a)
  • 85 (a)
(Mus musculus)
Mammalia Lipg 35
  • 81.9 (n)
  • 80.36 (a)
Lipg 16
Lipg 36
  • 80 (a)
(Pan troglodytes)
Mammalia LIPG 35
  • 99.47 (n)
  • 99.8 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Lipg 35
  • 81.06 (n)
  • 79.84 (a)
(Monodelphis domestica)
Mammalia LIPG 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves LIPG 35
  • 70.18 (n)
  • 73.26 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia LIPG 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lipg 35
  • 66.53 (n)
  • 66.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69106 35
(Danio rerio)
Actinopterygii lipg 35
  • 62.63 (n)
  • 62 (a)
zgc55345 35
lipg 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6271 37
  • 37 (a)
CG6277 37
  • 37 (a)
CG6472 37
  • 34 (a)
CG5966 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
-- 36
  • 22 (a)
Species with no ortholog for LIPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPG Gene

Gene Tree for LIPG (if available)
Gene Tree for LIPG (if available)

Paralogs for LIPG Gene

Paralogs for LIPG Gene

Selected SIMAP similar genes for LIPG Gene using alignment to 4 proteins: Pseudogenes for LIPG Gene

genes like me logo Genes that share paralogs with LIPG: view

Variants for LIPG Gene

Sequence variations from dbSNP and Humsavar for LIPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs868192 -- 49,561,042(+) AAGTT(C/T)TCCCT upstream-variant-2KB, utr-variant-5-prime
rs874565 -- 49,562,320(+) AACTC(A/C)GTTCC synonymous-codon, reference, intron-variant
rs874566 -- 49,562,371(+) GGGAG(C/T)CCCGT reference, synonymous-codon, intron-variant
rs1320699 -- 49,569,608(+) CTCCC(A/C)AATGA intron-variant
rs1320700 -- 49,569,646(+) GCTTT(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPG Gene

Variant ID Type Subtype PubMed ID
nsv438288 CNV Loss 16468122
esv1216550 CNV Deletion 17803354

Relevant External Links for LIPG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPG Gene

Disorders for LIPG Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for LIPG Gene in MalaCards »

(1) Diseases for LIPG Gene including...

(1) University of Copenhagen DISEASES for LIPG Gene

(9) Novoseek inferred disease relationships for LIPG Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 54.8 21
dyslipidemia 34.8 1
cardiovascular diseases 34.5 5
inflammation 22.6 24
coronary heart disease 20.8 3

Relevant External Links for LIPG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LIPG: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for LIPG Gene

Publications for LIPG Gene

  1. Cloning of a unique lipase from endothelial cells extends the lipase gene family. (PMID: 10318835) Hirata K. … Quertermous T. (J. Biol. Chem. 1999) 2 3 4 23
  2. The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women. (PMID: 12867537) Paradis M.E. … Lamarche B. (J. Lipid Res. 2003) 3 23 48
  3. Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children. (PMID: 12884003) Yamakawa-Kobayashi K. … Hamaguchi H. (Hum. Genet. 2003) 3 23 48
  4. Higher order lipase gene association with plasma triglycerides. (PMID: 15961789) Reilly M.P. … Rader D.J. (J. Lipid Res. 2005) 3 23 48
  5. Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels. (PMID: 17526978) Shimizu M. … Yokoyama M. (Circ. J. 2007) 3 23 48

Products for LIPG Gene

Sources for LIPG Gene

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