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Aliases for LIPG Gene

Aliases for LIPG Gene

  • Lipase G, Endothelial Type 2 3 5
  • Endothelial Cell-Derived Lipase 3 4
  • Lipase, Endothelial 2 3
  • EC 3.1.1.3 4 61
  • EDL 3 4
  • EL 3 4
  • Lipoprotein Lipase H 3
  • Endothelial Lipase 3
  • EC 3.1.1 61
  • PRO719 3

External Ids for LIPG Gene

Previous GeneCards Identifiers for LIPG Gene

  • GC18P047247
  • GC18P046887
  • GC18P045340
  • GC18P045342
  • GC18P047088
  • GC18P043942

Summaries for LIPG Gene

Entrez Gene Summary for LIPG Gene

  • The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPG Gene

LIPG (Lipase G, Endothelial Type) is a Protein Coding gene. Diseases associated with LIPG include Gastric Leiomyoma and Wolman Disease. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPG Gene

  • Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Tocris Summary for LIPG Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPG Gene

Genomics for LIPG Gene

Regulatory Elements for LIPG Gene

Enhancers for LIPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F049721 1.5 FANTOM5 Ensembl ENCODE 26.6 +164.0 163992 6.0 PKNOX1 ATF1 FEZF1 GLIS2 FOS SP5 JUNB TBX21 SREBF1 CBX8 LIPG ENSG00000264269 RPL17 SCARNA17 ENSG00000267674 GC18M049670
GH18F049645 1.1 Ensembl ENCODE 30.7 +86.5 86469 3.7 BCOR CTCF SIX4 JUN CEBPG RAD21 FOSL1 ZNF121 ZFHX2 POLR2A LIPG SMUG1P1 LOC105372112
GH18F049638 1.2 Ensembl ENCODE 17.9 +78.8 78803 2.3 PKNOX1 MLX ARID4B FEZF1 YY1 FOS ZNF263 MXD4 MIER2 PPARG LIPG SMUG1P1 LOC105372112
GH18F049629 0.9 ENCODE 20.5 +69.7 69702 1.4 ATF1 THRB RAD21 RARA YY1 CREM THAP11 CEBPB NR2F2 KAT8 LIPG ACAA2 ENSG00000252139 SCARNA17 SMUG1P1 LOC105372112
GH18F049655 1 ENCODE 17.1 +95.5 95468 1.6 FEZF1 ZNF2 GTF3C2 GLIS2 ZNF302 FOS ZNF263 SP3 TSHZ1 ZNF488 ENSG00000264269 RPL17 LIPG DYM SMUG1P1 GC18M049670
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPG on UCSC Golden Path with GeneCards custom track

Promoters for LIPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001515087 1401 2601 ATF1 ARID4B ZNF2 YY1 ZNF416 FOS ZNF263 SP3 NFYC REST

Genomic Location for LIPG Gene

Chromosome:
18
Start:
49,560,699 bp from pter
End:
49,599,182 bp from pter
Size:
38,484 bases
Orientation:
Plus strand

Genomic View for LIPG Gene

Genes around LIPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPG Gene

Proteins for LIPG Gene

  • Protein details for LIPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X9-LIPE_HUMAN
    Recommended name:
    Endothelial lipase
    Protein Accession:
    Q9Y5X9
    Secondary Accessions:
    • B0LPG6
    • Q6P9C8
    • Q6UW82

    Protein attributes for LIPG Gene

    Size:
    500 amino acids
    Molecular mass:
    56795 Da
    Quaternary structure:
    • Head to tail homodimer.
    Miscellaneous:
    • It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

    Alternative splice isoforms for LIPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPG Gene

Selected DME Specific Peptides for LIPG Gene

Q9Y5X9:
  • RLSPDDA
  • PVGHIDIYPNGG
  • CLSCRKNRCN
  • GRITGLD
  • VHLIGYSLGAHV
  • RVKSGETQ
  • KMYLKTR
  • GLDPAGP

Post-translational modifications for LIPG Gene

  • Glycosylation at Asn 80, Asn 136, Asn 393, Asn 469, and Asn 491
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LIPG

Domains & Families for LIPG Gene

Gene Families for LIPG Gene

Suggested Antigen Peptide Sequences for LIPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5X9

UniProtKB/Swiss-Prot:

LIPE_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPG: view

Function for LIPG Gene

Molecular function for LIPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serum.
UniProtKB/Swiss-Prot Function:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Enzyme Numbers (IUBMB) for LIPG Gene

Gene Ontology (GO) - Molecular Function for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity TAS --
GO:0004620 phospholipase activity IDA 10192396
GO:0004806 triglyceride lipase activity IEA --
GO:0008201 heparin binding IEA --
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IDA 10318835
genes like me logo Genes that share ontologies with LIPG: view
genes like me logo Genes that share phenotypes with LIPG: view

Animal Models for LIPG Gene

MGI Knock Outs for LIPG:

Animal Model Products

  • Taconic Biosciences Mouse Models for LIPG

miRNA for LIPG Gene

miRTarBase miRNAs that target LIPG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIPG Gene

Localization for LIPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPG gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 10192396
GO:0005769 early endosome IDA 23918928
GO:0005794 Golgi apparatus IDA 23918928
GO:0009986 cell surface IDA 23918928
genes like me logo Genes that share ontologies with LIPG: view

Pathways & Interactions for LIPG Gene

genes like me logo Genes that share pathways with LIPG: view

Pathways by source for LIPG Gene

Gene Ontology (GO) - Biological Process for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,TAS 10192396
GO:0007584 response to nutrient IEA --
GO:0008283 cell proliferation IEA --
GO:0009395 phospholipid catabolic process NAS 19136670
GO:0010983 positive regulation of high-density lipoprotein particle clearance IMP 19136670
genes like me logo Genes that share ontologies with LIPG: view

No data available for SIGNOR curated interactions for LIPG Gene

Drugs & Compounds for LIPG Gene

(16) Drugs for LIPG Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Orlistat Approved, Investigational Pharma Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(20) Additional Compounds for LIPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for LIPG Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4

(1) ApexBio Compounds for LIPG Gene

Compound Action Cas Number
XEN445 Endothelial lipase(EL) inhibitor 1515856-92-4
genes like me logo Genes that share compounds with LIPG: view

Transcripts for LIPG Gene

Unigene Clusters for LIPG Gene

Lipase, endothelial:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPG Gene

No ASD Table

Relevant External Links for LIPG Gene

GeneLoc Exon Structure for
LIPG
ECgene alternative splicing isoforms for
LIPG

Expression for LIPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPG Gene

This gene is overexpressed in Thyroid (x25.3) and Liver (x10.6).

Protein differential expression in normal tissues from HIPED for LIPG Gene

This gene is overexpressed in Placenta (39.7) and Prostate (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIPG Gene



Protein tissue co-expression partners for LIPG Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPG Gene:

LIPG

SOURCE GeneReport for Unigene cluster for LIPG Gene:

Hs.465102

mRNA Expression by UniProt/SwissProt for LIPG Gene:

Q9Y5X9-LIPE_HUMAN
Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.
genes like me logo Genes that share expression patterns with LIPG: view

Orthologs for LIPG Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPG 34 35
  • 99.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LIPG 34 35
  • 85.53 (n)
cow
(Bos Taurus)
Mammalia LOC509808 34
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Lipg 34 16 35
  • 81.9 (n)
rat
(Rattus norvegicus)
Mammalia Lipg 34
  • 81.06 (n)
oppossum
(Monodelphis domestica)
Mammalia LIPG 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIPG 34 35
  • 70.18 (n)
lizard
(Anolis carolinensis)
Reptilia LIPG 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lipg 34
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