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Aliases for LIPG Gene

Aliases for LIPG Gene

  • Lipase G, Endothelial Type 2 3 5
  • Endothelial Cell-Derived Lipase 3 4
  • Lipase, Endothelial 2 3
  • EC 3.1.1.3 4 58
  • EDL 3 4
  • EL 3 4
  • Lipoprotein Lipase H 3
  • Endothelial Lipase 3
  • EC 3.1.1 58
  • PRO719 3

External Ids for LIPG Gene

Previous GeneCards Identifiers for LIPG Gene

  • GC18P047247
  • GC18P046887
  • GC18P045340
  • GC18P045342
  • GC18P047088
  • GC18P043942

Summaries for LIPG Gene

Entrez Gene Summary for LIPG Gene

  • The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPG Gene

LIPG (Lipase G, Endothelial Type) is a Protein Coding gene. Diseases associated with LIPG include Gastric Leiomyoma and Hyperalphalipoproteinemia. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPG Gene

  • Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Tocris Summary for LIPG Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Additional gene information for LIPG Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPG Gene

Genomics for LIPG Gene

Regulatory Elements for LIPG Gene

Enhancers for LIPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H049721 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +164.0 163992 6 PKNOX1 FOXA2 FEZF1 GLIS2 FOS ATF7 SP5 JUNB SREBF1 SMARCA4 LIPG SCARNA17 ENSG00000267674 GC18M049670
GH18H049645 0.9 Ensembl ENCODE 30.7 +86.5 86469 3 CTCF JUN MNT RAD21 JUND ZFHX2 POLR2A HNF4A EGR2 LIPG SMUG1P1 LOC105372112
GH18H049629 0.9 ENCODE 20.5 +69.7 69702 1 FOXA2 ATF1 THRB RAD21 RARA YY1 ATF7 CREM THAP11 CEBPB LIPG ACAA2 ENSG00000252139 SCARNA17 SMUG1P1 LOC105372112
GH18H049681 0.7 ENCODE 25.8 +122.0 121971 1 FOXA2 MAX PPARG RAD21 NR2F2 YY1 JUND ATF3 ZSCAN5C HNF4G LIPG GC18M049670 SMUG1P1
GH18H049638 1 ENCODE 17.9 +78.8 78803 2 FOXA2 MLX ARID4B YY1 FOS MXD4 REST MIER2 PPARG KAT8 LIPG SMUG1P1 LOC105372112
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPG on UCSC Golden Path with GeneCards custom track

Promoters for LIPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103222 1401 601 HDAC1 TBP ATF1 ARID4B ZNF76 ZNF2 RAD21 ZEB1 YY1 ZNF366

Genomic Location for LIPG Gene

Chromosome:
18
Start:
49,560,699 bp from pter
End:
49,599,182 bp from pter
Size:
38,484 bases
Orientation:
Plus strand

Genomic View for LIPG Gene

Genes around LIPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPG Gene

Proteins for LIPG Gene

  • Protein details for LIPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5X9-LIPE_HUMAN
    Recommended name:
    Endothelial lipase
    Protein Accession:
    Q9Y5X9
    Secondary Accessions:
    • B0LPG6
    • Q6P9C8
    • Q6UW82

    Protein attributes for LIPG Gene

    Size:
    500 amino acids
    Molecular mass:
    56795 Da
    Quaternary structure:
    • Head to tail homodimer.
    Miscellaneous:
    • It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

    Alternative splice isoforms for LIPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPG Gene

Selected DME Specific Peptides for LIPG Gene

Q9Y5X9:
  • RLSPDDA
  • PVGHIDIYPNGG
  • CLSCRKNRCN
  • GRITGLD
  • VHLIGYSLGAHV
  • RVKSGETQ
  • KMYLKTR
  • GLDPAGP

Post-translational modifications for LIPG Gene

  • Glycosylation at Asn80, posLast=136136, Asn393, posLast=469469, and posLast=491491
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for LIPG

Domains & Families for LIPG Gene

Gene Families for LIPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LIPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5X9

UniProtKB/Swiss-Prot:

LIPE_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPG: view

Function for LIPG Gene

Molecular function for LIPG Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by serum.
UniProtKB/Swiss-Prot Function:
Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Enzyme Numbers (IUBMB) for LIPG Gene

Phenotypes From GWAS Catalog for LIPG Gene

Gene Ontology (GO) - Molecular Function for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004465 lipoprotein lipase activity EXP 19567873
GO:0004620 phospholipase activity IDA 10192396
GO:0004806 triglyceride lipase activity IEA --
GO:0008201 heparin binding IEA --
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IDA 10318835
genes like me logo Genes that share ontologies with LIPG: view
genes like me logo Genes that share phenotypes with LIPG: view

Animal Models for LIPG Gene

MGI Knock Outs for LIPG:

Animal Model Products

  • Taconic Biosciences Mouse Models for LIPG

CRISPR Products

miRNA for LIPG Gene

miRTarBase miRNAs that target LIPG

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIPG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIPG Gene

Localization for LIPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPG gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 10192396
GO:0005769 early endosome IDA 23918928
GO:0005794 Golgi apparatus IDA 23918928
GO:0009986 cell surface IDA 23918928
genes like me logo Genes that share ontologies with LIPG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPG Gene

Pathways & Interactions for LIPG Gene

genes like me logo Genes that share pathways with LIPG: view

Pathways by source for LIPG Gene

Gene Ontology (GO) - Biological Process for LIPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS,IEA 10192396
GO:0007584 response to nutrient IEA --
GO:0008283 cell proliferation IEA --
GO:0009395 phospholipid catabolic process NAS 19136670
GO:0010983 positive regulation of high-density lipoprotein particle clearance IMP 19136670
genes like me logo Genes that share ontologies with LIPG: view

No data available for SIGNOR curated interactions for LIPG Gene

Drugs & Compounds for LIPG Gene

(17) Drugs for LIPG Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Orlistat Approved, Investigational Pharma Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Myristic acid Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(20) Additional Compounds for LIPG Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for LIPG Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4

(1) ApexBio Compounds for LIPG Gene

Compound Action Cas Number
XEN445 Endothelial lipase(EL) inhibitor 1515856-92-4
genes like me logo Genes that share compounds with LIPG: view

Drug Products

Transcripts for LIPG Gene

Unigene Clusters for LIPG Gene

Lipase, endothelial:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIPG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LIPG Gene

No ASD Table

Relevant External Links for LIPG Gene

GeneLoc Exon Structure for
LIPG
ECgene alternative splicing isoforms for
LIPG

Expression for LIPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPG Gene

This gene is overexpressed in Thyroid (x25.3) and Liver (x10.6).

Protein differential expression in normal tissues from HIPED for LIPG Gene

This gene is overexpressed in Placenta (39.7) and Prostate (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIPG Gene



Protein tissue co-expression partners for LIPG Gene

NURSA nuclear receptor signaling pathways regulating expression of LIPG Gene:

LIPG

SOURCE GeneReport for Unigene cluster for LIPG Gene:

Hs.465102

mRNA Expression by UniProt/SwissProt for LIPG Gene:

Q9Y5X9-LIPE_HUMAN
Tissue specificity: High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.

Evidence on tissue expression from TISSUES for LIPG Gene

  • Heart(4.4)
  • Nervous system(4.1)
  • Bone marrow(4)
  • Lung(3)
  • Eye(2.9)
  • Liver(2.7)
  • Intestine(2.5)
  • Blood(2.2)
  • Thyroid gland(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LIPG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPG Gene

Orthologs for LIPG Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPG 33 34
  • 99.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LIPG 33 34
  • 85.53 (n)
cow
(Bos Taurus)
Mammalia LOC509808 33
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Lipg 33 16 34
  • 81.9 (n)
rat
(Rattus norvegicus)
Mammalia Lipg 33
  • 81.06 (n)
oppossum
(Monodelphis domestica)
Mammalia LIPG 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIPG 33 34
  • 70.18 (n)
lizard
(Anolis carolinensis)
Reptilia LIPG 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lipg 33
  • 66.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69106 33
zebrafish
(Danio rerio)
Actinopterygii lipg 33 34
  • 62.63 (n)
zgc55345 33
fruit fly
(Drosophila melanogaster)
Insecta CG6271 35
  • 37 (a)
CG6277 35
  • 37 (a)
CG6472 35
  • 34 (a)
CG5966 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
Species where no ortholog for LIPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPG Gene

ENSEMBL:
Gene Tree for LIPG (if available)
TreeFam:
Gene Tree for LIPG (if available)

Paralogs for LIPG Gene

Paralogs for LIPG Gene

(7) SIMAP similar genes for LIPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LIPG: view

Variants for LIPG Gene

Sequence variations from dbSNP and Humsavar for LIPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000023797 -- 49,588,369(+) CCTCC(A/G)CCTCC intron-variant
rs1000147016 -- 49,563,698(+) CCATT(C/G)AGCAA intron-variant
rs1000239096 -- 49,562,786(+) CAGAG(A/C)TGTGT intron-variant
rs1000244213 -- 49,568,669(+) AGCCA(C/T)CGCAC intron-variant
rs1000288514 -- 49,575,282(+) CATTC(A/T)GCACA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LIPG Gene

Variant ID Type Subtype PubMed ID
esv1216550 CNV deletion 17803354
nsv1150682 CNV insertion 26484159
nsv438288 CNV loss 16468122
nsv576863 CNV gain 21841781

Variation tolerance for LIPG Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPG Gene

Human Gene Mutation Database (HGMD)
LIPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPG Gene

Disorders for LIPG Gene

MalaCards: The human disease database

(3) MalaCards diseases for LIPG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric leiomyoma
  • leiomyoma of the stomach
hyperalphalipoproteinemia
  • cholesterol-ester transfer protein deficiency
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search LIPG in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPG

Genetic Association Database (GAD)
LIPG
Human Genome Epidemiology (HuGE) Navigator
LIPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPG
genes like me logo Genes that share disorders with LIPG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPG Gene

Publications for LIPG Gene

  1. Cloning of a unique lipase from endothelial cells extends the lipase gene family. (PMID: 10318835) Hirata K … Quertermous T (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. (PMID: 19411665) Jensen MK … Overvad K (European heart journal 2009) 3 22 45 60
  3. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. (PMID: 19380136) Smith CE … Ordovás JM (Atherosclerosis 2009) 3 22 45 60
  4. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. (PMID: 19287092) Edmondson AC … Rader DJ (The Journal of clinical investigation 2009) 3 22 45 60
  5. [The -384A >C polymorphism of endothelial lipase gene promoter region in Chinese healthy normolipidemic and endogenous hypertriglyceridemic subjects]. (PMID: 18683147) Huang Y … Liu BW (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2008) 3 22 45 60

Products for LIPG Gene

Sources for LIPG Gene

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