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Aliases for LIPF Gene

Aliases for LIPF Gene

  • Lipase F, Gastric Type 2 3 5
  • Gastric Triacylglycerol Lipase 2 3
  • Lipase, Gastric 2 3
  • Gastric Lipase 3 4
  • EC 4 61
  • GL 3 4
  • EC 3.1.1 61
  • HLAL 3
  • HGL 3

External Ids for LIPF Gene

Previous GeneCards Identifiers for LIPF Gene

  • GC10P089305
  • GC10P089569
  • GC10P090555
  • GC10P090088
  • GC10P090415
  • GC10P084058

Summaries for LIPF Gene

Entrez Gene Summary for LIPF Gene

  • This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for LIPF Gene

LIPF (Lipase F, Gastric Type) is a Protein Coding gene. Diseases associated with LIPF include Osteopetrosis, Autosomal Recessive 5 and Wolman Disease. Among its related pathways are triacylglycerol biosynthesis and Lipoprotein metabolism. GO annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPK.

Tocris Summary for LIPF Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPF Gene

Genomics for LIPF Gene

Regulatory Elements for LIPF Gene

Enhancers for LIPF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LIPF on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPF Gene

88,664,389 bp from pter
88,678,815 bp from pter
14,427 bases
Plus strand

Genomic View for LIPF Gene

Genes around LIPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPF Gene

Proteins for LIPF Gene

  • Protein details for LIPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gastric triacylglycerol lipase
    Protein Accession:
    Secondary Accessions:
    • B7Z723
    • F5H1P4
    • Q2M1P6
    • Q5VXI7
    • Q5VXI8
    • Q658L8

    Protein attributes for LIPF Gene

    398 amino acids
    Molecular mass:
    45238 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA29414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIPF Gene

    Alternative splice isoforms for LIPF Gene


neXtProt entry for LIPF Gene

Post-translational modifications for LIPF Gene

  • Glycosylation at Asn 34, Asn 99, Asn 271, and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPF Gene

Domains & Families for LIPF Gene

Gene Families for LIPF Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPF: view

Function for LIPF Gene

Molecular function for LIPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.

Enzyme Numbers (IUBMB) for LIPF Gene

Gene Ontology (GO) - Molecular Function for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 3304425
GO:0008289 lipid binding NAS 2753032
GO:0016615 malate dehydrogenase activity IEA --
genes like me logo Genes that share ontologies with LIPF: view

Phenotypes for LIPF Gene

GenomeRNAi human phenotypes for LIPF:
genes like me logo Genes that share phenotypes with LIPF: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPF Gene

Localization for LIPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPF Gene


Subcellular locations from

Jensen Localization Image for LIPF Gene COMPARTMENTS Subcellular localization image for LIPF gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LIPF: view

Pathways & Interactions for LIPF Gene

genes like me logo Genes that share pathways with LIPF: view

Pathways by source for LIPF Gene

Gene Ontology (GO) - Biological Process for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0006641 triglyceride metabolic process NAS 3304425
GO:0016042 lipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for SIGNOR curated interactions for LIPF Gene

Drugs & Compounds for LIPF Gene

(15) Drugs for LIPF Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Water Approved Pharma 0
Undecyl-Phosphinic Acid Butyl Ester Experimental Pharma Target 0
MYRISTIC ACID Experimental Pharma 0
palmitic acid Experimental Pharma Full agonist, Agonist 22

(21) Additional Compounds for LIPF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for LIPF Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4
genes like me logo Genes that share compounds with LIPF: view

Transcripts for LIPF Gene

Unigene Clusters for LIPF Gene

Lipase, gastric:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP3: - -
SP4: -

Relevant External Links for LIPF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIPF Gene

mRNA expression in normal human tissues for LIPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPF Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for LIPF Gene

This gene is overexpressed in Stomach (39.3) and Cardia (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPF Gene

Protein tissue co-expression partners for LIPF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIPF Gene:


SOURCE GeneReport for Unigene cluster for LIPF Gene:

genes like me logo Genes that share expression patterns with LIPF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LIPF Gene

Orthologs for LIPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIPF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LIPF 34
  • 81.28 (n)
  • 73.3 (a)
  • 74 (a)
(Canis familiaris)
Mammalia LIPF 34
  • 85.26 (n)
  • 85.43 (a)
  • 85 (a)
(Mus musculus)
Mammalia Lipf 34
  • 80.93 (n)
  • 77.72 (a)
Lipf 16
Lipf 35
  • 78 (a)
(Pan troglodytes)
Mammalia LIPF 34
  • 98.94 (n)
  • 98.77 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lipf 34
  • 80.08 (n)
  • 76.2 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
(Gallus gallus)
Aves -- 35
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11598 36
  • 32 (a)
CG11600 36
  • 29 (a)
CG11608 36
  • 33 (a)
CG17097 36
  • 31 (a)
CG18302 36
  • 37 (a)
CG18530 36
  • 31 (a)
CG2772 36
  • 37 (a)
CG3635 36
  • 35 (a)
CG5932 36
  • 37 (a)
CG6113 36
  • 38 (a)
CG6753 36
  • 37 (a)
CG7329 36
  • 32 (a)
CG8093 36
  • 35 (a)
Lip1 36
  • 36 (a)
Lip3 36
  • 38 (a)
CG11406 35
  • 30 (a)
CG11598 35
  • 31 (a)
CG11600 35
  • 28 (a)
CG11608 35
  • 28 (a)
CG17097 35
  • 12 (a)
CG18284 35
  • 26 (a)
CG18302 35
  • 31 (a)
CG2772 35
  • 31 (a)
CG31091 35
  • 29 (a)
CG31871 35
  • 27 (a)
CG31872 35
  • 11 (a)
CG3635 35
  • 31 (a)
CG6753 35
  • 32 (a)
CG7329 35
  • 27 (a)
CG8093 35
  • 33 (a)
Lip1 35
  • 30 (a)
Lip3 35
  • 36 (a)
Lip4 35
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002353 34
  • 45.85 (n)
  • 36.79 (a)
(Caenorhabditis elegans)
Secernentea F01G10.7 36
  • 37 (a)
F46B6.8 36
  • 42 (a)
F54F3.3 36
  • 42 (a)
K04A8.5 36
  • 36 (a)
R11G11.14 36
  • 42 (a)
Y50E8A.7 36
  • 32 (a)
Y57E12B.3 36
  • 41 (a)
ZK6.7a 36
  • 43 (a)
ZK6.7b 36
  • 45 (a)
lipl-1 35
  • 41 (a)
lipl-7 35
  • 34 (a)
lipl-8 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 35
  • 21 (a)
YEH1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MPL1 34
  • 47.58 (n)
  • 37.53 (a)
(Oryza sativa)
Liliopsida Os08g0529800 34
  • 45.05 (n)
  • 36.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
Species where no ortholog for LIPF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPF Gene

Gene Tree for LIPF (if available)
Gene Tree for LIPF (if available)

Paralogs for LIPF Gene

Paralogs for LIPF Gene

(6) SIMAP similar genes for LIPF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPF: view

Variants for LIPF Gene

Sequence variations from dbSNP and Humsavar for LIPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs814628 - 88,669,895(+) AGAAA(A/G)CTGGA reference, missense
rs6586145 - 88,673,588(+) TTCAG(A/T)TTATA reference, missense
rs17333991 - 88,678,526(+) CTGAC(A/C/T)CCCAA reference, missense
rs3858282 -- 88,674,654(+) GTTAT(C/T)GGGAA intron-variant
rs814616 -- 88,674,232(+) GGCGC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPF Gene

Variant ID Type Subtype PubMed ID
esv3624131 CNV loss 21293372
esv3624132 CNV gain 21293372
esv3624134 CNV gain 21293372
nsv831941 CNV gain 17160897

Variation tolerance for LIPF Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPF Gene

Disorders for LIPF Gene

MalaCards: The human disease database

(5) MalaCards diseases for LIPF Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteopetrosis, autosomal recessive 5
  • osteopetrosis autosomal recessive 5
wolman disease
  • cholesteryl ester storage disease
cholesterol ester storage disease
  • cholesteryl ester storage disease
  • obesity, association with
pancreatitis, hereditary
  • pancreatitis, chronic
- elite association - COSMIC cancer census association via MalaCards
Search LIPF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LIPF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPF Gene

Publications for LIPF Gene

  1. Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. (PMID: 10358049) Roussel A. … Cambillau C. (J. Biol. Chem. 1999) 3 4 22 65
  2. The acid lipase gene family: three enzymes, one highly conserved gene structure. (PMID: 9186906) Lohse P. … Seidel D. (J. Lipid Res. 1997) 2 3 22 65
  3. Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. (PMID: 3304425) Bodmer M.W. … Lowe P.A. (Biochim. Biophys. Acta 1987) 2 3 4 65
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 65
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65

Products for LIPF Gene

Sources for LIPF Gene