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Aliases for LIPF Gene

Aliases for LIPF Gene

  • Lipase, Gastric 2 3
  • Gastric Lipase 3 4
  • EC 3.1.1.3 4 63
  • GL 3 4
  • EC 3.1.1 63
  • HLAL 3
  • HGL 3

External Ids for LIPF Gene

Previous GeneCards Identifiers for LIPF Gene

  • GC10P089305
  • GC10P089569
  • GC10P090555
  • GC10P090088
  • GC10P090415
  • GC10P084058

Summaries for LIPF Gene

Entrez Gene Summary for LIPF Gene

  • This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for LIPF Gene

LIPF (Lipase, Gastric) is a Protein Coding gene. Diseases associated with LIPF include wolman disease and cholesterol ester storage disease. Among its related pathways are Metabolism and triacylglycerol biosynthesis. GO annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPA.

Tocris Summary for LIPF Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPF Gene

Genomics for LIPF Gene

Regulatory Elements for LIPF Gene

Genomic Location for LIPF Gene

Chromosome:
10
Start:
88,664,389 bp from pter
End:
88,678,815 bp from pter
Size:
14,427 bases
Orientation:
Plus strand

Genomic View for LIPF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPF Gene

Proteins for LIPF Gene

  • Protein details for LIPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07098-LIPG_HUMAN
    Recommended name:
    Gastric triacylglycerol lipase
    Protein Accession:
    P07098
    Secondary Accessions:
    • B7Z723
    • F5H1P4
    • Q2M1P6
    • Q5VXI7
    • Q5VXI8
    • Q658L8

    Protein attributes for LIPF Gene

    Size:
    398 amino acids
    Molecular mass:
    45238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIPF Gene

    Alternative splice isoforms for LIPF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPF Gene

Proteomics data for LIPF Gene at MOPED

Post-translational modifications for LIPF Gene

  • Glycosylation at Asn 34, Asn 99, Asn 271, and Asn 327
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPF Gene

Domains & Families for LIPF Gene

Gene Families for LIPF Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P07098

UniProtKB/Swiss-Prot:

LIPG_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPF: view

Function for LIPF Gene

Molecular function for LIPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

Enzyme Numbers (IUBMB) for LIPF Gene

Gene Ontology (GO) - Molecular Function for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 3304425
GO:0008289 lipid binding NAS 2753032
GO:0016615 malate dehydrogenase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
genes like me logo Genes that share ontologies with LIPF: view

Phenotypes for LIPF Gene

GenomeRNAi human phenotypes for LIPF:
genes like me logo Genes that share phenotypes with LIPF: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIPF

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPF Gene

Localization for LIPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPF Gene COMPARTMENTS Subcellular localization image for LIPF gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LIPF: view

Pathways & Interactions for LIPF Gene

genes like me logo Genes that share pathways with LIPF: view

Pathways by source for LIPF Gene

1 Qiagen pathway for LIPF Gene
2 BioSystems pathways for LIPF Gene

Gene Ontology (GO) - Biological Process for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0006629 lipid metabolic process --
GO:0006641 triglyceride metabolic process NAS 3304425
GO:0016042 lipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for SIGNOR curated interactions for LIPF Gene

Drugs & Compounds for LIPF Gene

(12) Drugs for LIPF Gene - From: DrugBank, DGIdb, HMDB, NovoSeek, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 49
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Undecyl-Phosphinic Acid Butyl Ester Experimental Pharma Target 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20

(23) Additional Compounds for LIPF Gene - From: HMDB, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with LIPF: view

Transcripts for LIPF Gene

Unigene Clusters for LIPF Gene

Lipase, gastric:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIPF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3: - -
SP4: -

Relevant External Links for LIPF Gene

GeneLoc Exon Structure for
LIPF
ECgene alternative splicing isoforms for
LIPF

Expression for LIPF Gene

mRNA expression in normal human tissues for LIPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPF Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for LIPF Gene

This gene is overexpressed in Stomach (39.3) and Cardia (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPF Gene



SOURCE GeneReport for Unigene cluster for LIPF Gene Hs.523130

genes like me logo Genes that share expression patterns with LIPF: view

Protein tissue co-expression partners for LIPF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LIPF Gene

Orthologs for LIPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIPF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIPF 35
  • 81.28 (n)
  • 73.3 (a)
LIPF 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIPF 35
  • 85.26 (n)
  • 85.43 (a)
LIPF 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lipf 35
  • 80.93 (n)
  • 77.72 (a)
Lipf 16
Lipf 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIPF 35
  • 98.94 (n)
  • 98.77 (a)
LIPF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lipf 35
  • 80.08 (n)
  • 76.2 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11598 37
  • 32 (a)
CG11600 37
  • 29 (a)
CG11608 37
  • 33 (a)
CG17097 37
  • 31 (a)
CG18302 37
  • 37 (a)
CG18530 37
  • 31 (a)
CG2772 37
  • 37 (a)
CG3635 37
  • 35 (a)
CG5932 37
  • 37 (a)
CG6113 37
  • 38 (a)
CG6753 37
  • 37 (a)
CG7329 37
  • 32 (a)
CG8093 37
  • 35 (a)
Lip1 37
  • 36 (a)
Lip3 37
  • 38 (a)
CG11406 36
  • 30 (a)
ManyToMany
CG11598 36
  • 31 (a)
ManyToMany
CG11600 36
  • 28 (a)
ManyToMany
CG11608 36
  • 28 (a)
ManyToMany
CG17097 36
  • 12 (a)
ManyToMany
CG18284 36
  • 26 (a)
ManyToMany
CG18302 36
  • 31 (a)
ManyToMany
CG2772 36
  • 31 (a)
ManyToMany
CG31091 36
  • 29 (a)
ManyToMany
CG31871 36
  • 27 (a)
ManyToMany
CG31872 36
  • 11 (a)
ManyToMany
CG3635 36
  • 31 (a)
ManyToMany
CG6753 36
  • 32 (a)
ManyToMany
CG7329 36
  • 27 (a)
ManyToMany
CG8093 36
  • 33 (a)
ManyToMany
Lip1 36
  • 30 (a)
ManyToMany
Lip3 36
  • 36 (a)
ManyToMany
Lip4 36
  • 31 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002353 35
  • 45.85 (n)
  • 36.79 (a)
worm
(Caenorhabditis elegans)
Secernentea F01G10.7 37
  • 37 (a)
F46B6.8 37
  • 42 (a)
F54F3.3 37
  • 42 (a)
K04A8.5 37
  • 36 (a)
R11G11.14 37
  • 42 (a)
Y50E8A.7 37
  • 32 (a)
Y57E12B.3 37
  • 41 (a)
ZK6.7a 37
  • 43 (a)
ZK6.7b 37
  • 45 (a)
lipl-1 36
  • 41 (a)
ManyToMany
lipl-7 36
  • 34 (a)
ManyToMany
lipl-8 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 36
  • 21 (a)
OneToMany
YEH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPL1 35
  • 47.58 (n)
  • 37.53 (a)
rice
(Oryza sativa)
Liliopsida Os08g0529800 35
  • 45.05 (n)
  • 36.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for LIPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPF Gene

ENSEMBL:
Gene Tree for LIPF (if available)
TreeFam:
Gene Tree for LIPF (if available)

Paralogs for LIPF Gene

Paralogs for LIPF Gene

(6) SIMAP similar genes for LIPF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPF: view

Variants for LIPF Gene

Sequence variations from dbSNP and Humsavar for LIPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs814616 -- 88,674,232(+) GGCGC(A/G)ATCTC intron-variant
rs814621 -- 88,662,913(+) tgaaa(A/G)aaaag upstream-variant-2KB
rs814622 -- 88,663,495(+) aggga(A/C)cgtca upstream-variant-2KB
rs814623 -- 88,665,323(+) AATGA(A/G)TTCCC intron-variant
rs814624 -- 88,665,570(+) TTAAG(C/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPF Gene

Variant ID Type Subtype PubMed ID
nsv831941 CNV Gain 17160897

Variation tolerance for LIPF Gene

Residual Variation Intolerance Score: 20.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPF Gene

HapMap Linkage Disequilibrium report
LIPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPF Gene

Disorders for LIPF Gene

MalaCards: The human disease database

(3) MalaCards diseases for LIPF Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
wolman disease
  • cholesteryl ester storage disease
cholesterol ester storage disease
  • cholesteryl ester storage disease
pancreatitis, hereditary
  • pancreatitis, chronic
- elite association
Search LIPF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPF

Genetic Association Database (GAD)
LIPF
Human Genome Epidemiology (HuGE) Navigator
LIPF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPF
genes like me logo Genes that share disorders with LIPF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPF Gene

Publications for LIPF Gene

  1. The acid lipase gene family: three enzymes, one highly conserved gene structure. (PMID: 9186906) Lohse P. … Seidel D. (J. Lipid Res. 1997) 2 23 67
  2. The effect of diet on the expression of lipase genes in the midgut of the lightbrown apple moth (Epiphyas postvittana Walker; Tortricidae). (PMID: 20002216) Christeller J.T. … Simpson R.M. (Insect Mol. Biol. 2010) 23 67
  3. Simulation of gastric lipolysis and prediction of felodipine release from a matrix tablet in the fed stomach. (PMID: 19429420) Diakidou A. … Reppas C. (Eur J Pharm Sci 2009) 23 67
  4. Wolman disease/cholesteryl ester storage disease: efficacy of plant-produced human lysosomal acid lipase in mice. (PMID: 18413899) Du H. … Grabowski G.A. (J. Lipid Res. 2008) 23 67
  5. Lifestyle and pharmacological approaches to weight loss: efficacy and safety. (PMID: 18987274) Bray G.A. (J. Clin. Endocrinol. Metab. 2008) 25 26

Products for LIPF Gene

Sources for LIPF Gene

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