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Aliases for LIPF Gene

Aliases for LIPF Gene

  • Lipase F, Gastric Type 2 3 5
  • Gastric Triacylglycerol Lipase 2 3
  • Lipase, Gastric 2 3
  • Gastric Lipase 3 4
  • EC 3.1.1.3 4 61
  • GL 3 4
  • EC 3.1.1 61
  • HLAL 3
  • HGL 3

External Ids for LIPF Gene

Previous GeneCards Identifiers for LIPF Gene

  • GC10P089305
  • GC10P089569
  • GC10P090555
  • GC10P090088
  • GC10P090415
  • GC10P084058

Summaries for LIPF Gene

Entrez Gene Summary for LIPF Gene

  • This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for LIPF Gene

LIPF (Lipase F, Gastric Type) is a Protein Coding gene. Diseases associated with LIPF include Wolman Disease and Cholesterol Ester Storage Disease. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPK.

Tocris Summary for LIPF Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPF Gene

Genomics for LIPF Gene

Regulatory Elements for LIPF Gene

Enhancers for LIPF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F088835 1.4 FANTOM5 Ensembl ENCODE 9 +171.1 171128 1.0 WRNIP1 BRCA1 ZNF2 RAD21 ZEB1 RFX5 ZNF366 ZNF143 CREM DEK ACTA2-AS1 STAMBPL1 LIPM LIPF ANKRD22 FAS LIPN IFIT3 IFIT2
GH10F088833 1.1 FANTOM5 Ensembl ENCODE 9.6 +169.4 169412 0.8 CTCF ZNF664 SMC3 RAD21 STAMBPL1 ANKRD22 ACTA2-AS1 LIPM LIPJ ENSG00000201548 RNLS LIPF LIPN FAS
GH10F088759 0.8 Ensembl ENCODE 9.7 +96.0 96049 2.3 MAX MYC ZBTB40 GABPA LIPN LIPM LIPF LIPK RCBTB2P1
GH10F088824 0.7 ENCODE 10.1 +161.3 161307 3.1 TBP PKNOX1 MTA2 ASH2L BMI1 TBX21 EP300 ZNF664 SP1 POLR2A ANKRD22 LIPM ACTA2-AS1 STAMBPL1 ENSG00000201548 RNLS LIPJ LIPF FAS LIPN
GH10F088820 0.6 ENCODE 10.9 +156.8 156803 1.3 RFX1 CEBPB STAT3 MAX EP300 RFX5 LIPN LIPF ENSG00000201548 RNLS LIPJ LIPM ANKRD22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPF on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPF Gene

Chromosome:
10
Start:
88,664,389 bp from pter
End:
88,678,815 bp from pter
Size:
14,427 bases
Orientation:
Plus strand

Genomic View for LIPF Gene

Genes around LIPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPF Gene

Proteins for LIPF Gene

  • Protein details for LIPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07098-LIPG_HUMAN
    Recommended name:
    Gastric triacylglycerol lipase
    Protein Accession:
    P07098
    Secondary Accessions:
    • B7Z723
    • F5H1P4
    • Q2M1P6
    • Q5VXI7
    • Q5VXI8
    • Q658L8

    Protein attributes for LIPF Gene

    Size:
    398 amino acids
    Molecular mass:
    45238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIPF Gene

    Alternative splice isoforms for LIPF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPF Gene

Selected DME Specific Peptides for LIPF Gene

P07098:
  • EMAKYDLP
  • GNSRGNTW
  • SQMITYWGYP
  • ALAPVATVKYT
  • TEDGYIL
  • TIGFIAFS
  • FILADAG
  • LADAGYDVW
  • NLPNNSL
  • HNPAGTS
  • YVGHSQGTTIGFI
  • YNHLDFIWAMDAPQ

Post-translational modifications for LIPF Gene

  • Glycosylation at Asn 34, Asn 99, Asn 271, and Asn 327
  • Modification sites at PhosphoSitePlus

Domains & Families for LIPF Gene

Gene Families for LIPF Gene

Graphical View of Domain Structure for InterPro Entry

P07098

UniProtKB/Swiss-Prot:

LIPG_HUMAN :
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPF: view

Function for LIPF Gene

Molecular function for LIPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.

Enzyme Numbers (IUBMB) for LIPF Gene

Gene Ontology (GO) - Molecular Function for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 3304425
GO:0008289 lipid binding NAS 2753032
GO:0016615 malate dehydrogenase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPF: view

Phenotypes for LIPF Gene

GenomeRNAi human phenotypes for LIPF:
genes like me logo Genes that share phenotypes with LIPF: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPF Gene

Localization for LIPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPF gene
Compartment Confidence
extracellular 5
lysosome 4
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LIPF: view

Pathways & Interactions for LIPF Gene

genes like me logo Genes that share pathways with LIPF: view

Pathways by source for LIPF Gene

Gene Ontology (GO) - Biological Process for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process NAS 3304425
GO:0016042 lipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for SIGNOR curated interactions for LIPF Gene

Drugs & Compounds for LIPF Gene

(15) Drugs for LIPF Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Water Approved Pharma 0
Undecyl-Phosphinic Acid Butyl Ester Experimental Pharma Target 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(21) Additional Compounds for LIPF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for LIPF Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4
genes like me logo Genes that share compounds with LIPF: view

Transcripts for LIPF Gene

Unigene Clusters for LIPF Gene

Lipase, gastric:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIPF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3: - -
SP4: -

Relevant External Links for LIPF Gene

GeneLoc Exon Structure for
LIPF
ECgene alternative splicing isoforms for
LIPF

Expression for LIPF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPF Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for LIPF Gene

This gene is overexpressed in Stomach (39.3) and Cardia (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPF Gene



Protein tissue co-expression partners for LIPF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIPF Gene:

LIPF

SOURCE GeneReport for Unigene cluster for LIPF Gene:

Hs.523130
genes like me logo Genes that share expression patterns with LIPF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LIPF Gene

Orthologs for LIPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPF 34 35
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia LIPF 34 35
  • 85.26 (n)
cow
(Bos Taurus)
Mammalia LIPF 34 35
  • 81.28 (n)
mouse
(Mus musculus)
Mammalia Lipf 34 16 35
  • 80.93 (n)
rat
(Rattus norvegicus)
Mammalia Lipf 34
  • 80.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002353 34
  • 45.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lip3 36 35
  • 38 (a)
CG6113 36
  • 38 (a)
CG18302 36 35
  • 37 (a)
CG2772 36 35
  • 37 (a)
CG5932 36
  • 37 (a)
Lip1 36 35
  • 36 (a)
CG3635 36 35
  • 35 (a)
CG8093 35 36
  • 33 (a)
ManyToMany
CG6753 35 36
  • 32 (a)
ManyToMany
CG17097 36 35
  • 31 (a)
CG18530 36
  • 31 (a)
CG11598 35 36
  • 31 (a)
ManyToMany
Lip4 35
  • 31 (a)
ManyToMany
CG11406 35
  • 30 (a)
ManyToMany
CG31091 35
  • 29 (a)
ManyToMany
CG11600 35 36
  • 28 (a)
ManyToMany
CG11608 35 36
  • 28 (a)
ManyToMany
CG31871 35
  • 27 (a)
ManyToMany
CG7329 35 36
  • 27 (a)
ManyToMany
CG18284 35
  • 26 (a)
ManyToMany
CG31872 35
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK6.7b 36
  • 45 (a)
ZK6.7a 36
  • 43 (a)
F46B6.8 36
  • 42 (a)
F54F3.3 36
  • 42 (a)
R11G11.14 36
  • 42 (a)
lipl-1 35
  • 41 (a)
ManyToMany
Y57E12B.3 36
  • 41 (a)
F01G10.7 36
  • 37 (a)
K04A8.5 36
  • 36 (a)
lipl-7 35
  • 34 (a)
ManyToMany
Y50E8A.7 36
  • 32 (a)
lipl-8 35
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 35
  • 21 (a)
OneToMany
YEH1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MPL1 34
  • 47.58 (n)
rice
(Oryza sativa)
Liliopsida Os08g0529800 34
  • 45.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for LIPF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPF Gene

ENSEMBL:
Gene Tree for LIPF (if available)
TreeFam:
Gene Tree for LIPF (if available)

Paralogs for LIPF Gene

Paralogs for LIPF Gene

(6) SIMAP similar genes for LIPF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPF: view

Variants for LIPF Gene

Sequence variations from dbSNP and Humsavar for LIPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1064289 -- 88,673,669(+) AGATG(C/T)TGAAT reference, synonymous-codon
rs111263622 -- 88,673,624(+) ACAAC(C/T)TCTTT reference, missense
rs11202801 -- 88,662,796(+) AGAAT(A/C)TACAA upstream-variant-2KB
rs11202802 -- 88,664,318(+) TTTTA(C/G)TTTTG upstream-variant-2KB
rs11202803 -- 88,665,915(+) TGTAT(C/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPF Gene

Variant ID Type Subtype PubMed ID
nsv831941 CNV gain 17160897
esv3624134 CNV gain 21293372
esv3624132 CNV gain 21293372
esv3624131 CNV loss 21293372

Variation tolerance for LIPF Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPF Gene

Disorders for LIPF Gene

MalaCards: The human disease database

(2) MalaCards diseases for LIPF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wolman disease
  • cholesteryl ester storage disease
cholesterol ester storage disease
  • cholesteryl ester storage disease
- elite association - COSMIC cancer census association via MalaCards
Search LIPF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPF

Genetic Association Database (GAD)
LIPF
Human Genome Epidemiology (HuGE) Navigator
LIPF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPF
genes like me logo Genes that share disorders with LIPF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPF Gene

Publications for LIPF Gene

  1. Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. (PMID: 10358049) Roussel A. … Cambillau C. (J. Biol. Chem. 1999) 3 4 22 64
  2. The acid lipase gene family: three enzymes, one highly conserved gene structure. (PMID: 9186906) Lohse P. … Seidel D. (J. Lipid Res. 1997) 2 3 22 64
  3. Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. (PMID: 3304425) Bodmer M.W. … Lowe P.A. (Biochim. Biophys. Acta 1987) 2 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64

Products for LIPF Gene