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Aliases for LIPF Gene

Aliases for LIPF Gene

  • Lipase F, Gastric Type 2 3 5
  • Gastric Triacylglycerol Lipase 2 3
  • Lipase, Gastric 2 3
  • Gastric Lipase 3 4
  • EC 3.1.1.3 4 58
  • GL 3 4
  • EC 3.1.1 58
  • HLAL 3
  • HGL 3

External Ids for LIPF Gene

Previous GeneCards Identifiers for LIPF Gene

  • GC10P089305
  • GC10P089569
  • GC10P090555
  • GC10P090088
  • GC10P090415
  • GC10P084058

Summaries for LIPF Gene

Entrez Gene Summary for LIPF Gene

  • This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for LIPF Gene

LIPF (Lipase F, Gastric Type) is a Protein Coding gene. Diseases associated with LIPF include Wolman Disease and Cholesterol Ester Storage Disease. Among its related pathways are Metabolism and triacylglycerol biosynthesis. GO annotations related to this gene include lipid binding and malate dehydrogenase activity. An important paralog of this gene is LIPK.

Tocris Summary for LIPF Gene

  • Lipases are esterase enzymes that catalyze the hydrolysis of ester bonds within hydrophobic lipids. The diverse class of lipase enzymes includes diacylglycerol lipase (DAGL) and lipoprotein lipase (LPL) and endothelial lipase (LIPG).

Additional gene information for LIPF Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPF Gene

Genomics for LIPF Gene

Regulatory Elements for LIPF Gene

Enhancers for LIPF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H088835 1.4 FANTOM5 Ensembl ENCODE 9 +171.2 171154 0 RB1 BRCA1 ZNF2 RAD21 ZEB1 RFX5 YY1 ZNF366 ZNF143 ATF7 ACTA2-AS1 STAMBPL1 LIPM LIPF ANKRD22 FAS LIPN IFIT3 IFIT2
GH10H088759 0.8 Ensembl ENCODE 9.7 +96.0 96049 2 POLR2A MAX MYC GABPA LIPN LIPM LIPF LIPK RCBTB2P1
GH10H088824 0.7 ENCODE 10.1 +161.3 161307 3 PKNOX1 BACH1 BMI1 ZNF664 POLR2A ATF7 IKZF2 CHD2 SMARCA5 ZNF687 ANKRD22 LIPM ACTA2-AS1 STAMBPL1 LIPJ RNLS ENSG00000201548 LIPF FAS LIPN
GH10H088820 0.6 ENCODE 10.9 +156.8 156803 1 RFX1 STAT3 MAX CEBPB CEBPG EP300 RFX5 LIPN LIPF ENSG00000201548 RNLS LIPJ LIPM ANKRD22
GH10H088833 0.7 FANTOM5 ENCODE 9 +169.6 169550 0 ZNF664 CTCF ANKRD22 ACTA2-AS1 STAMBPL1 LIPM LIPF LIPN FAS LIPK IFIT3 IFIT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIPF on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPF Gene

Chromosome:
10
Start:
88,664,389 bp from pter
End:
88,678,815 bp from pter
Size:
14,427 bases
Orientation:
Plus strand

Genomic View for LIPF Gene

Genes around LIPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPF Gene

Proteins for LIPF Gene

  • Protein details for LIPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07098-LIPG_HUMAN
    Recommended name:
    Gastric triacylglycerol lipase
    Protein Accession:
    P07098
    Secondary Accessions:
    • B7Z723
    • F5H1P4
    • Q2M1P6
    • Q5VXI7
    • Q5VXI8
    • Q658L8

    Protein attributes for LIPF Gene

    Size:
    398 amino acids
    Molecular mass:
    45238 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29414.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIPF Gene

    Alternative splice isoforms for LIPF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIPF Gene

Selected DME Specific Peptides for LIPF Gene

P07098:
  • EMAKYDLP
  • GNSRGNTW
  • SQMITYWGYP
  • ALAPVATVKYT
  • TEDGYIL
  • TIGFIAFS
  • FILADAG
  • LADAGYDVW
  • NLPNNSL
  • HNPAGTS
  • YVGHSQGTTIGFI
  • YNHLDFIWAMDAPQ

Post-translational modifications for LIPF Gene

  • Glycosylation at Asn34, posLast=9999, Asn271, and posLast=327327
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for LIPF Gene

Gene Families for LIPF Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P07098

UniProtKB/Swiss-Prot:

LIPG_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPF: view

Function for LIPF Gene

Molecular function for LIPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.

Enzyme Numbers (IUBMB) for LIPF Gene

Gene Ontology (GO) - Molecular Function for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004806 triglyceride lipase activity TAS 3304425
GO:0008289 lipid binding NAS 2753032
GO:0016615 malate dehydrogenase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with LIPF: view

Phenotypes for LIPF Gene

GenomeRNAi human phenotypes for LIPF:
genes like me logo Genes that share phenotypes with LIPF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIPF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LIPF Gene

Localization for LIPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIPF gene
Compartment Confidence
extracellular 5
lysosome 4
mitochondrion 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LIPF Gene

Pathways & Interactions for LIPF Gene

genes like me logo Genes that share pathways with LIPF: view

Pathways by source for LIPF Gene

Gene Ontology (GO) - Biological Process for LIPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006108 malate metabolic process IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process NAS 3304425
GO:0016042 lipid catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LIPF: view

No data available for SIGNOR curated interactions for LIPF Gene

Drugs & Compounds for LIPF Gene

(16) Drugs for LIPF Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor, Target Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
Water Approved Pharma 0
Undecyl-Phosphinic Acid Butyl Ester Experimental Pharma Target 0
Myristic acid Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22

(21) Additional Compounds for LIPF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(3) Tocris Compounds for LIPF Gene

Compound Action Cas Number
GSK 264220A Endothelial lipase and lipoprotein lipase inhibitor 685506-42-7
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 96829-58-2
XEN 445 Selective endothelial lipase inhibitor; orally bioavailable 1515856-92-4
genes like me logo Genes that share compounds with LIPF: view

Transcripts for LIPF Gene

Unigene Clusters for LIPF Gene

Lipase, gastric:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIPF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LIPF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3: - -
SP4: -

Relevant External Links for LIPF Gene

GeneLoc Exon Structure for
LIPF
ECgene alternative splicing isoforms for
LIPF

Expression for LIPF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIPF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPF Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for LIPF Gene

This gene is overexpressed in Stomach (39.3) and Cardia (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPF Gene



Protein tissue co-expression partners for LIPF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIPF Gene:

LIPF

SOURCE GeneReport for Unigene cluster for LIPF Gene:

Hs.523130

Evidence on tissue expression from TISSUES for LIPF Gene

  • Stomach(5)
genes like me logo Genes that share expression patterns with LIPF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIPF Gene

Orthologs for LIPF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIPF 34 33
  • 98.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LIPF 33 34
  • 85.26 (n)
cow
(Bos Taurus)
Mammalia LIPF 34 33
  • 81.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lipf 16 34 33
  • 80.93 (n)
rat
(Rattus norvegicus)
Mammalia Lipf 33
  • 80.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002353 33
  • 45.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6113 35
  • 38 (a)
Lip3 35 34
  • 38 (a)
CG18302 35 34
  • 37 (a)
CG2772 35 34
  • 37 (a)
CG5932 35
  • 37 (a)
CG6753 35 34
  • 37 (a)
Lip1 35 34
  • 36 (a)
CG3635 35 34
  • 35 (a)
CG8093 35 34
  • 35 (a)
CG11608 35 34
  • 33 (a)
CG11598 35 34
  • 32 (a)
CG7329 35 34
  • 32 (a)
CG17097 35 34
  • 31 (a)
CG18530 35
  • 31 (a)
Lip4 34
  • 31 (a)
ManyToMany
CG11406 34
  • 30 (a)
ManyToMany
CG11600 35 34
  • 29 (a)
CG31091 34
  • 29 (a)
ManyToMany
CG31871 34
  • 27 (a)
ManyToMany
CG18284 34
  • 26 (a)
ManyToMany
CG31872 34
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZK6.7b 35
  • 45 (a)
ZK6.7a 35
  • 43 (a)
F46B6.8 35
  • 42 (a)
F54F3.3 35
  • 42 (a)
R11G11.14 35
  • 42 (a)
Y57E12B.3 35
  • 41 (a)
lipl-1 34
  • 41 (a)
ManyToMany
F01G10.7 35
  • 37 (a)
K04A8.5 35
  • 36 (a)
lipl-7 34
  • 34 (a)
ManyToMany
Y50E8A.7 35
  • 32 (a)
lipl-8 34
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TGL1 34
  • 21 (a)
OneToMany
YEH1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MPL1 33
  • 47.58 (n)
rice
(Oryza sativa)
Liliopsida Os08g0529800 33
  • 45.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for LIPF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIPF Gene

ENSEMBL:
Gene Tree for LIPF (if available)
TreeFam:
Gene Tree for LIPF (if available)

Paralogs for LIPF Gene

Paralogs for LIPF Gene

(6) SIMAP similar genes for LIPF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LIPF: view

Variants for LIPF Gene

Sequence variations from dbSNP and Humsavar for LIPF Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000153663 -- 88,670,577(+) AGAAT(A/T)GCAAG intron-variant
rs1000542651 -- 88,676,422(+) GACTA(A/T)GCATT intron-variant
rs1000950768 -- 88,662,414(+) AAGCA(A/G)TGGGG upstream-variant-2KB
rs1000974982 -- 88,676,739(+) TGCTT(C/G)CAGGT intron-variant
rs1001095907 -- 88,670,008(+) GTTAT(A/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIPF Gene

Variant ID Type Subtype PubMed ID
esv3624131 CNV loss 21293372
esv3624132 CNV gain 21293372
esv3624134 CNV gain 21293372
nsv831941 CNV gain 17160897

Variation tolerance for LIPF Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIPF Gene

Disorders for LIPF Gene

MalaCards: The human disease database

(4) MalaCards diseases for LIPF Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wolman disease
  • cholesteryl ester storage disease
cholesterol ester storage disease
  • wolman disease
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
pancreatitis, hereditary
  • pancreatitis, chronic
- elite association - COSMIC cancer census association via MalaCards
Search LIPF in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIPF

Genetic Association Database (GAD)
LIPF
Human Genome Epidemiology (HuGE) Navigator
LIPF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPF
genes like me logo Genes that share disorders with LIPF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIPF Gene

Publications for LIPF Gene

  1. Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. (PMID: 10358049) Roussel A … Cambillau C (The Journal of biological chemistry 1999) 3 4 22 60
  2. The acid lipase gene family: three enzymes, one highly conserved gene structure. (PMID: 9186906) Lohse P … Seidel D (Journal of lipid research 1997) 2 3 22 60
  3. Molecular cloning of a human gastric lipase and expression of the enzyme in yeast. (PMID: 3304425) Bodmer MW … Lowe PA (Biochimica et biophysica acta 1987) 2 3 4 60
  4. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 45 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for LIPF Gene

Sources for LIPF Gene

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