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LIPE Gene

protein-coding   GIFtS: 67
GCID: GC19M042906

Lipase, Hormone-Sensitive

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lipase, Hormone-Sensitive1 2
HSL2 3
EC 3.1.1.793 8
LHS2 5
Hormone-Sensitive Lipase2
Hormone-Sensitive Lipase Testicular Isoform2

External Ids:    HGNC: 66211   Entrez Gene: 39912   Ensembl: ENSG000000794357   OMIM: 1517505   UniProtKB: Q054693   

Export aliases for LIPE gene to outside databases

Previous GC identifers: GC19M043552 GC19M043297 GC19M047581 GC19M047597 GC19M039335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LIPE Gene:
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start
codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters
to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others,
where it hydrolyzes stored triglycerides to free fatty acids. (provided by RefSeq, Jul 2008)

GeneCards Summary for LIPE Gene:
LIPE (lipase, hormone-sensitive) is a protein-coding gene. Diseases associated with LIPE include familial combined hyperlipidemia, and hypoplastic left heart syndrome. GO annotations related to this gene include protein kinase binding and hormone-sensitive lipase activity.

UniProtKB/Swiss-Prot: LIPS_HUMAN, Q05469
Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in
steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone
production

Gene Wiki entry for LIPE (Hormone-sensitive lipase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIPE gene promoter:
         p53   AML1a   Sp1   c-Ets-1   Evi-1   PPAR-alpha   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIPE promoter sequence
   Search Chromatin IP Primers for LIPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

LIPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPE gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042906:  view genomic region     (about GC identifiers)

Start:
42,905,659 bp from pter      End:
42,931,578 bp from pter
Size:
25,920 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIPS_HUMAN, Q05469 (See protein sequence)
Recommended Name: Hormone-sensitive lipase  
Size: 1076 amino acids; 116598 Da
Subunit: Interacts with PTRF in the adipocyte cytoplasm
Secondary accessions: Q3LRT2 Q6NSL7
Alternative splicing: 2 isoforms:  Q05469-1   Q05469-2   

Explore the universe of human proteins at neXtProt for LIPE: NX_Q05469

Explore proteomics data for LIPE at MOPED

Post-translational modifications: 

  • Phosphorylation by AMPK may block translocation to lipid droplets (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LIPE (Q05469) (see all 14)
     YYAQRLL  GDSAGGNL  PSTPSDVNF  HGGGFVAQTS 


    See LIPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005348.2  
    ENSEMBL proteins: 
     ENSP00000244289   ENSP00000469545   ENSP00000472218   ENSP00000469990   ENSP00000472531  
     ENSP00000469268   ENSP00000469030  
    Reactome Protein details: Q05469

    LIPE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for LIPE
    OriGene Protein Over-expression Lysate for LIPE
    OriGene MassSpec for LIPE
    OriGene Custom Protein Services for LIPE
    GenScript Custom Purified and Recombinant Proteins Services for LIPE
    Novus Biologicals LIPE Protein
    Novus Biologicals LIPE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIPE

    LIPE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LIPE
    R&D Systems Antibodies for LIPE (Hormone-sensitive Lipase/HSL)
    Cell Signaling Technology (CST) Antibodies for LIPE  (HSL)
    OriGene Antibodies for LIPE
    OriGene Custom Antibody Services for LIPE
    Novus Biologicals LIPE Antibodies
    Abcam antibodies for LIPE (Q6NSL7, Q05469)
    Cloud-Clone Corp. Antibodies for LIPE
    ThermoFisher Antibody for LIPE
    LSBio Antibodies in human, mouse, rat for LIPE

    LIPE Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIPE
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LIPE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIPE
    Cloud-Clone Corp. CLIAs for LIPE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013094 AB_hydrolase_3
     IPR010468 HSL_N
     IPR002168 Lipase_GDXG_AS

    Graphical View of Domain Structure for InterPro Entry Q05469

    ProtoNet protein and cluster: Q05469

    2 Blocks protein domains:
    IPB002168 Lipolytic enzyme
    IPB010468 Hormone-sensitive lipase


    UniProtKB/Swiss-Prot: LIPS_HUMAN, Q05469
    Similarity: Belongs to the 'GDXG' lipolytic enzyme family


    LIPE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPS_HUMAN, Q05469
    Function: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in
    steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone
    production
    Catalytic activity: Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate
    Catalytic activity: Monoacylglycerol + H(2)O = glycerol + a carboxylate
    Enzyme regulation: Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines.
    Dephosphorylation and inactivation are controlled by insulin

         Genatlas biochemistry entry for LIPE:
    lipase,hormone sensitive with two isoforms expressed in adipose tissue (HSLadi),testis (HSLtes),associated with
    obesity and non insulin dependent diabetes

         Enzyme Number (IUBMB): EC 3.1.1.791 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0005515protein binding IPI17026959
    GO:0016298lipase activity ----
    GO:0016787hydrolase activity ----
    GO:0019901protein kinase binding IEA--
         
    LIPE for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LIPE:
     Decreased Wnt reporter activit  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lipe):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  integument  liver/biliary system  muscle 
     reproductive system 

    LIPE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LIPE: Lipetm1Ishi Lipetm1Rze

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIPE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIPE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIPE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIPE

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LIPE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIPE (see all 11):
    hsa-miR-3910 hsa-miR-15a hsa-miR-657 hsa-miR-497 hsa-miR-424 hsa-miR-124 hsa-miR-506 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidLIPE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LIPE
    Predesigned siRNA for gene silencing in human, mouse, rat LIPE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIPE

    Clone
    Products:
         
    OriGene clones in human, mouse for LIPE (see all 6)
    OriGene ORF clones in mouse, rat for LIPE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPE (NM_005357)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIPE
    Browse ESI BIO Cell Lines and PureStem Progenitors for LIPE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIPS_HUMAN, Q05469: Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density
    caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    extracellular2
    mitochondrion2
    nucleus2
    peroxisome2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005811lipid particle ISS--
    GO:0005829cytosol IEA--
    GO:0005901caveola IEA--

    LIPE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LIPE About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Lipoprotein metabolism
    Lipid digestion, mobilization, and transport0.59
    Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis0.00
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5G Protein Signaling Pathways
    Signal transduction cAMP signaling0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LIPE
        Activation of PKA through GPCR
    AMPK Enzyme Complex Pathway
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 Cell Signaling Technology (CST) Pathway for LIPE
        Glucose / Energy Metabolism

    3 GeneGo (Thomson Reuters) Pathways for LIPE
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Regulation of lipid metabolism Insulin signaling-generic cascades

    Selected BioSystems Pathways for LIPE (see all 6)
        Adipogenesis
    Insulin Signaling
    AMPK signaling
    Fatty Acid Beta Oxidation
    Triacylglyceride Synthesis

    1 Reactome Pathway for LIPE
        Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis


    1 Kegg Pathway  (Kegg details for LIPE):
        Insulin signaling pathway

    UniProtKB/Swiss-Prot: LIPS_HUMAN, Q05469
    Pathway: Glycerolipid metabolism; triacylglycerol degradation


    LIPE for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LIPE: 

              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LIPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LIPE (Q054692, 3 ENSP000002442894) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKACAP176123, ENSP000003095914I2D: score=3 STRING: ENSP00000309591
    MAPK1P284823, ENSP000002158324I2D: score=2 STRING: ENSP00000215832
    STARP496753, ENSP000002764494I2D: score=2 STRING: ENSP00000276449
    FABP4P150903, ENSP000002561044I2D: score=2 STRING: ENSP00000256104
    FABP9Q0Z7S83, ENSP000003683624I2D: score=1 STRING: ENSP00000368362
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS3420405
    GO:0008152metabolic process ----
    GO:0008203cholesterol metabolic process IEA--
    GO:0016042lipid catabolic process ISS--
    GO:0019433triglyceride catabolic process TAS--

    LIPE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIPE (LIPS)

    Selected HMDB Compounds for LIPE (see all 1206)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Arachidonylglycerol2-Arachidonyl glycerol;(all-Z)-2-hydroxy-1-(hydroxymethyl)ethyl ester 5,8,11,14-Eicosatetraenoic acid (see all 21)53847-30-6--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----

    Selected Novoseek inferred chemical compound relationships for LIPE gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triacylglycerol 81.6 73 16767439 (3), 12562895 (3), 18357681 (2), 15255786 (2) (see all 34)
    glycerol 75.9 28 17587400 (2), 12701046 (2), 1861630 (2), 9467584 (1) (see all 19)
    fatty acid 74.1 102 18820256 (5), 11734578 (4), 8166251 (2), 11420177 (2) (see all 48)
    monoacylglycerol 71.2 19 15627655 (3), 7942281 (1), 1356829 (1), 15562022 (1) (see all 11)
    lipid 70.8 138 7942281 (3), 12832420 (3), 19515989 (3), 8906873 (3) (see all 74)
    isoproterenol 58.5 7 8858214 (1), 12404207 (1), 8720602 (1), 10634941 (1) (see all 6)
    p-nitrophenyl butyrate 57.9 6 16325466 (2), 8906873 (1), 19018281 (1)
    glycerol 3-phosphate 55 10 1714464 (1), 8536680 (1), 15810992 (1), 18547799 (1) (see all 6)
    acipimox 52.5 2 16189176 (1), 8720602 (1)
    cholesterol 50.4 40 12036961 (2), 14506837 (2), 7942281 (1), 7817870 (1) (see all 24)



    LIPE for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LIPE gene: 
    NM_005357.3  

    Unigene Cluster for LIPE:

    Lipase, hormone-sensitive
    Hs.656980  [show with all ESTs]
    Unigene Representative Sequence: BC070041
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244289(uc002otr.3 uc002ots.1) ENST00000597620 ENST00000599918
    ENST00000600224 ENST00000602000 ENST00000599783 ENST00000599211 ENST00000597001
    ENST00000601189
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LIPE using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIPE (see all 11):
    hsa-miR-3910 hsa-miR-15a hsa-miR-657 hsa-miR-497 hsa-miR-424 hsa-miR-124 hsa-miR-506 hsa-miR-16
    SwitchGear 3'UTR luciferase reporter plasmidLIPE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LIPE
    Predesigned siRNA for gene silencing in human, mouse, rat LIPE
    Clone
    Products:
         
    OriGene clones in human, mouse for LIPE (see all 6)
    OriGene ORF clones in mouse, rat for LIPE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIPE (NM_005357)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIPE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LIPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIPE
      QuantiTect SYBR Green Assays in human, mouse, rat LIPE
      QuantiFast Probe-based Assays in human, mouse, rat LIPE

    Additional mRNA sequence: 

    AK292482.1 AK309893.1 BC029301.1 BC029961.1 BC070041.1 U40002.1 

    10 DOTS entries:

    DT.455313  DT.99933117  DT.100784516  DT.100784517  DT.100784514  DT.100666352  DT.100719598  DT.91747493 
    DT.95116775  DT.95169780 

    Selected AceView cDNA sequences (see all 111):

    CD514250 BC029961 BX281226 AW027306 BE855571 BX395039 CD245502 BC070041 
    AW136527 AI362136 BI826568 BU581127 AI376636 CB267298 BM930106 R53505 
    BI825158 CK825285 CK825284 CB053962 BI826036 BC029301 BI827706 BU580674 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LIPE (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14
    SP1:                          -     -     -                                                                                             
    SP2:                                                                                                              -                     
    SP3:                                                                                                              -                     
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for LIPE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LIPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCCTTCC
    LIPE Expression
    About this image


    LIPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Body Subcutaneous White Adipose
             White adipocyte-like cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
    LIPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIPE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656980
        Pathway & Disease-focused RT2 Profiler PCR Arrays including LIPE: 
              Fatty Acid Metabolism in human mouse rat
              Insulin Resistance in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LIPE gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lipe1 , 5 lipase, hormone sensitive1, 5 81.96(n)1
    84.28(a)1
      7 (13.78 cM)5
    168901  NM_010719.51  NP_034849.21 
     253795275 
    lizard
    (Anolis carolinensis)
    Reptilia LIPE6
    lipase, hormone-sensitive
    65(a)
    1 ↔ 1
    AAWZ02039940(21-5971)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.186192 Xenopus laevis transcribed sequence with weak similarity more 77.81(n)    BI443144.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.149822 Transcribed sequence with weak similarity to protein more 75.17(n)    BM036731.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110553 triacylglycerol lipase 55(a)   56F11   --
    worm
    (Caenorhabditis elegans)
    Secernentea C46C11.13 hormone sensitive lipase 33(a)   X(4672619-4678586)   --


    ENSEMBL Gene Tree for LIPE (if available)
    TreeFam Gene Tree for LIPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for LIPE    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365394
    A breast cancer sample4--see VAR_0365392 P Q mis40--------
    rs359385291,2,4
    ----see VAR_0251142 mis40--------
    rs343480281,2,4
    ----see VAR_0251102 mis40--------
    rs169757501,2,4
    ----see VAR_0251082 mis40--------
    rs339212161,2,4
    ----see VAR_0251152 mis40--------
    rs340807741,2,4
    ----see VAR_0251092 mis40--------
    rs169757481,2,4
    ----see VAR_0251112 mis40--------
    rs349960201,2,4
    ----see VAR_0251122 mis40--------
    rs37452381,2,4
    ----see VAR_0251132 mis40--------
    rs72462321,2,4
    ----see VAR_0251162 mis40--------

    HapMap Linkage Disequilibrium report for LIPE (42905659 - 42931578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LIPE (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422471CNV Deletion17116639
    nsv911804CNV Loss21882294
    nsv911782CNV Loss21882294
    nsv911785CNV Loss21882294
    dgv3885n71CNV Loss21882294
    nsv520239CNV Loss19592680
    dgv3889n71CNV Loss21882294
    dgv3887n71CNV Loss21882294
    nsv911807CNV Gain21882294
    nsv522854CNV Gain19592680

    Human Gene Mutation Database (HGMD): LIPE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIPE
    DNA2.0 Custom Variant and Variant Library Synthesis for LIPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151750    OMIM disorders: --

    Selected diseases for LIPE (see all 31):    
    About MalaCards
    familial combined hyperlipidemia    hypoplastic left heart syndrome    glucose intolerance    morbid obesity
    obesity, association with    lipodystrophy    polycystic ovary syndrome    growth hormone deficiency
    insulin resistance    coronary heart disease    hyperthyroidism    male infertility
    obesity    liposarcoma    infertility    colon adenocarcinoma
    atherosclerosis    breast and colorectal cancer    influenza    type 1 diabetes

    2 diseases from the University of Copenhagen DISEASES database for LIPE:
    Diabetes mellitus     Familial combined hyperlipidemia

    LIPE for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for LIPE gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 69 42 10946012 (3), 17327373 (2), 10193856 (2), 16249444 (2) (see all 27)
    hyperlipidemia familial combined 67.6 7 11979403 (2), 11932285 (1), 11298776 (1)
    insulin resistance 58.2 13 17356053 (2), 11932285 (2), 11731226 (1), 19996383 (1) (see all 7)
    insulin sensitivity 52.5 10 11714847 (2), 11731226 (1), 17016691 (1), 19131065 (1) (see all 7)
    hyperinsulinemia 38.7 1 17356053 (1)
    polycystic ovary syndrome 34.3 2 15733735 (1), 19423542 (1)
    lipodystrophy 26.8 2 19707470 (2)
    atherosclerosis 20.6 2 12036961 (1)
    necrosis 19.8 11 2332411 (2), 8194485 (1), 10889786 (1), 10334320 (1) (see all 7)
    glucose intolerance 17.8 1 1542265 (1)

    Genetic Association Database (GAD): LIPE
    Human Genome Epidemiology (HuGE) Navigator: LIPE (27 documents)

    Export disorders for LIPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIPE gene, integrated from 10 sources (see all 411):
    (articles sorted by number of sources associating them with LIPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. (PubMed id 8506334)1, 2, 3, 9 Langin D.... Holm C. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Molecular cloning, genomic organization, and expression of a testicular isoform of hormone-sensitive lipase. (PubMed id 8812477)1, 2, 9 Holst L.S.... Holm C. (Genomics 1996)
    3. Association and insulin regulated translocation of hormone-sensitive lipase with PTRF. (PubMed id 17026959)1, 2, 9 Aboulaich N.... Stralfors P. (Biochem. Biophys. Res. Commun. 2006)
    4. The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study. (PubMed id 11850754)1, 4, 9 Garenc C....Bouchard C. (Int. J. Obes. Relat. Metab. Disord. 2002)
    5. Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations. (PubMed id 14984467)1, 4, 9 Qi L....Ordovas J.M. (Clin. Genet. 2004)
    6. Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. (PubMed id 11731226)1, 4, 9 Talmud P.J....Wareham N.J. (Biochim. Biophys. Acta 2001)
    7. Association of lifestyle factors, polymorphisms in adiponectin, perilipin and hormone sensitive lipase, and clinical markers in Japanese males. (PubMed id 20495294)1, 4, 9 Sone Y....Otsuka Y. (J. Nutr. Sci. Vitaminol. 2010)
    8. Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene. (PubMed id 18249203)1, 4, 9 Jocken J.W....Saris W.H. (Metab. Clin. Exp. 2008)
    9. The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension. (PubMed id 17318300)1, 4, 9 Bernard N....GiguA"re Y. (J. Hum. Genet. 2007)
    10. Investigation into the role of the hormone sensitive lipase -60C&gt;G promoter variant in morbid obesity. (PubMed id 15871848)1, 4, 9 Talmud P.J....Beisiegel U. (Nutr Metab Cardiovasc Dis 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3991 HGNC: 6621 AceView: LIPE Ensembl:ENSG00000079435 euGenes: HUgn3991
    ECgene: LIPE Kegg: 3991 H-InvDB: LIPE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIPE Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/lipe/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIPE gene:
    Search GeneIP for patents involving LIPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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