Aliases for LIPE Gene
External Ids for LIPE Gene
Previous GeneCards Identifiers for LIPE Gene
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
GeneCards Summary for LIPE Gene
LIPE (Lipase E, Hormone Sensitive Type) is a Protein Coding gene. Diseases associated with LIPE include Lipodystrophy, Familial Partial, Type 6 and Lipe-Related Familial Partial Lipodystrophy. Among its related pathways are cAMP signaling pathway and Glucose / Energy Metabolism. GO annotations related to this gene include protein kinase binding and triglyceride lipase activity.
UniProtKB/Swiss-Prot for LIPE Gene
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.