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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LIPC Gene

protein-coding GIFtS: 62
GCID: GC15P058702

lipase, hepatic

Explore 82 diseases affiliated with
LIPC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lipase, Hepatic¹ ²		EC 3.1.1.3³ ⁸
HL¹ ² ³ ⁵		HDLCQ12² ⁵
HTGL¹ ² ³		LIPH² ⁵
Hepatic Lipase² ³		Hepatic Triacylglycerol Lipase²
Lipase Member C² ³		EC 3.1.1⁸

External Ids:	HGNC: 6619¹	Entrez Gene: 3990²	Ensembl: ENSG00000166035⁷	OMIM: 151670⁵	UniProtKB: P11150³

Export aliases for LIPC gene to outside databases

Previous GC identifers: GC15P054281 GC15P051771 GC15P056303 GC15P056440 GC15P056511 GC15P035548

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIPC:

LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride

hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIPC_HUMAN, P11150

Function: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and

acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin

Gene Wiki entry for LIPC (Hepatic lipase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LIPC gene promoter:
PPAR-gamma1 FOXJ2 (long isoform) FOXJ2 PPAR-gamma2 LCR-F1 RORalpha2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LIPC promoter sequence

Search SABiosciences Chromatin IP Primers for LIPC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIPC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21-q23 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q21-q23

LIPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIPC gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P058702: view genomic region (about GC identifiers)

Start:	58,702,768 bp from pter	End:	58,861,151 bp from pter
Size:	158,384 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIPC_HUMAN, P11150 (See protein sequence)

Recommended Name: Hepatic triacylglycerol lipase precursor

Size: 499 amino acids; 55914 Da

Subcellular location: Secreted

Secondary accessions: A2RUB4 A8K9B6 O43571 P78529 Q99465

Explore the universe of human proteins at neXtProt for LIPC: NX_P11150

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11150

4/11 DME Specific Peptides for LIPC (P11150) (see all 11)

RLSPDDA

KCSHERS

NKTYSFL

GRITGLD

LIPC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000227.2

ENSEMBL proteins:

ENSP00000348425 ENSP00000395569 ENSP00000299022 ENSP00000395002

Human Recombinant Protein Products for LIPC:

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	Uscn Proteins for LIPC

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005615	extracellular space	IDA	2839510
GO:0034364	high-density lipoprotein particle	IEA	--

LIPC for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LIPC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LIPC for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001024 LipOase_LH2

IPR008976 Lipase_LipOase

IPR000734 Lipase

IPR002333 Lipase_hep

IPR016272 Lipoprotein_lipase_LIPH

Graphical View of Domain Structure for InterPro Entry P11150

ProtoNet protein and cluster: P11150

4 Blocks protein families:

IPB000734 Lipase

IPB001024 Lipoxygenase

IPB002333 Hepatic lipase signature

IPB008262 Lipase

UniProtKB/Swiss-Prot: LIPC_HUMAN, P11150

Similarity: Belongs to the AB hydrolase superfamily. Lipase family

Similarity: Contains 1 PLAT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LIPC_HUMAN, P11150

Function: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and

acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin

Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

Genatlas biochemistry entry for LIPC:

lipase,hepatic,53kDa,plasma lipid transport

Enzyme Numbers (IUBMB): EC 3.1.1.3¹ ² EC 3.1.1²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004620	phospholipase activity	TAS	3244012
GO:0004806	triglyceride lipase activity	IDA	182536
GO:0005515	protein binding	--	--
GO:0008201	heparin binding	IEA	--
GO:0016298	lipase activity	--	--

LIPC for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lipc):

endocrine/exocrine gland

homeostasis/metabolism

reproductive system

LIPC for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Lipc^tm1Unc for LIPC

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LIPC

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

Fatty Acid Beta Oxidation

Fatty Acid Beta Oxidation

1.00

triacylglycerol degradation

triacylglycerol degradation

1.00

Glycerolipid metabolism

Glycerolipid metabolism

1.00

the visual cycle I (vertebrates)

retinol biosynthesis

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

5 BioSystems Pathways for LIPC

	Statin Pathway
	Fatty Acid Beta Oxidation
	Triacylglyceride Synthesis
	triacylglycerol degradation
	retinol biosynthesis

1 PharmGKB Pathway for LIPC

Statin Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for LIPC):

	Glycerolipid metabolism
	Metabolic pathways

LIPC for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LIPC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for LIPC (P11150³ ENSP00000299022⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOB	P04114³, ENSP00000233242⁴	I2D: score=2 STRING: ENSP00000233242
LRP1	Q07954³, ENSP00000243077⁴	I2D: score=2 STRING: ENSP00000243077
APOE	ENSP00000252486⁴	STRING: ENSP00000252486
CEL	ENSP00000361151⁴	STRING: ENSP00000361151
DGAT1	ENSP00000332258⁴	STRING: ENSP00000332258

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0006633	fatty acid biosynthetic process	IDA	182536
GO:0008203	cholesterol metabolic process	IEA	--
GO:0019433	triglyceride catabolic process	IDA	182536
GO:0030301	cholesterol transport	--	--

LIPC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LIPC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LIPC

10/1173 HMDB Compounds for LIPC (see all 1173) About this table

Compound	Synonyms	CAS #	PubMed Ids
TG(15:0/16:0/20:2(11Z,14Z))[iso6]	Tracylglycerol(15:0/16:0/20:2) (see all 15)	--	12486725
TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6]	TAG(15:0/16:0/20:3n6) (see all 16)	--	12486725
TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6]	TAG(15:0/16:0/20:4n6) (see all 15)	--	12486725
TG(15:0/18:0/18:2(9Z,12Z))[iso6]	TG(15:0/18:0/18:2w6) (see all 15)	--	12486725
TG(15:0/18:0/18:3(9Z,12Z,15Z))[iso6]	TAG(51:3) (see all 16)	--	12486725
TG(15:0/18:1(9Z)/16:0)[iso6]	Tracylglycerol(15:0/18:1w9/16:0) (see all 15)	--	12486725
TG(15:0/18:1(9Z)/16:1(9Z))[iso6]	TG(15:0/18:1/16:1) (see all 15)	--	12486725
TG(15:0/18:1(9Z)/18:1(9Z))[iso3]	TG(15:0/18:1n9/18:1n9) (see all 15)	--	12486725
TG(15:0/18:1(9Z)/18:2(9Z,12Z))[iso6]	Tracylglycerol(15:0/18:1/18:2) (see all 15)	--	12486725
TG(15:0/18:1(9Z)/18:3(9Z,12Z,15Z))[iso6]	Tracylglycerol(15:0/18:1/18:3) (see all 16)	--	12486725

10/67 Novoseek chemical compound relationships for LIPC gene (see all 67) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	84.1	389	9885775 (6), 1742328 (5), 10073966 (5), 12777471 (4) (see all 99)
cholesterol ester	80.8	35	12419479 (2), 19584682 (2), 12023990 (1), 16343038 (1) (see all 25)
lipid	73.9	155	11171785 (3), 12235167 (3), 1364970 (3), 10936588 (3) (see all 92)
triacylglycerol	68.7	45	2002032 (5), 1390640 (4), 2375781 (3), 2036455 (2) (see all 24)
phospholipid	64.4	76	1390640 (4), 9885775 (2), 9258411 (2), 10511296 (2) (see all 42)
heparin	59.4	62	16554020 (3), 1755003 (2), 8186654 (2), 10487498 (2) (see all 41)
fatty acid	50	30	8637399 (1), 9486964 (1), 10619982 (1), 18662427 (1) (see all 19)
gemfibrozil	44.8	7	7595182 (2), 8257455 (2), 8318063 (1)
bezafibrate	44.4	2	16338252 (2)
glycerides	43.4	3	9392420 (1), 9048565 (1)

Search CenterWatch for drugs/clinical trials and news about LIPC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LIPC gene:

NM_000236.2

Unigene Cluster for LIPC:

Lipase, hepatic

Hs.654472 [show with all ESTs]

Unigene Representative Sequence: BC146659

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000356113(uc010bga.2) ENST00000414170(uc010bfz.1) ENST00000560257

ENST00000299022(uc002afa.2) ENST00000559845(uc010bgb.1) ENST00000433326(uc010ugy.2)

ENST00000560664

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Additional cDNA sequence:

AK290062.1 AK292631.1 AK293324.1 AK309448.1 AK315306.1 BC132825.1 BC136495.1 BC146659.1

D83548.1 J03540.1 J03895.1 X07228.1

5 DOTS entries:

DT.315369 DT.100837211 DT.106064 DT.121059864 DT.315370

24/53 AceView cDNA sequences (see all 53):

CR596048 CR612434 CR590311 CR619207 BX422325 H57342 D83548 N63873

AU120729 AI193167 R99344 AV645541 W87730 AI823349 BX462874 R85611

BX094318 J03540 NM_000236 BX443795 CD514374 BX449129 J03895 N75990

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for LIPC About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9	^	10
SP1:
SP2:
SP3:					-		-		-		-
SP4:					-		-				-
SP5:

ECgene alternative splicing isoforms for LIPC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LIPC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCACAGGG

About this image

LIPC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Beating cell clusters (Spontaneous differen...)

Human kidney epithelial cell spheroids (Kidney spheroids for...)

See LIPC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIPC

SOURCE GeneReport for Unigene cluster: Hs.654472

SABiosciences Custom PCR Arrays for LIPC

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIPC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LIPC gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LIPC¹	lipase, hepatic	67.81(n) 65.95(a)		427495 XM_425067.3 XP_425067.3
lizard (Anolis carolinensis)	Reptilia	LIPC⁶	--	59(a)	1 ↔ 1	GL343573.1(239063-244721)
African clawed frog (Xenopus laevis)	Amphibia	Xl.17530²	Xenopus laevis transcribed sequence with weak similarity to protein spP11150 (H.sapiens) LIPH_HUMAN Triacylglycerol lipase, hepatic precursor (Hepatic lipase) (HL) less	73.33(n)		CB983238.1
zebrafish (Danio rerio)	Actinopterygii	zgc64081²	similar to lipase, hepatic	75.12(n)		393997 BC053243.1
fruit fly (Drosophila melanogaster)	Insecta	CG6847³	triacylglycerol lipase	37(a) (best of 2)		16F3 --

ENSEMBL Gene Tree for LIPC (if available)
TreeFam Gene Tree for LIPC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LIPC gene

LIPH² LIPG² PNLIPRP3² LPL² PNLIP² LIPI² PLA1A² PNLIPRP1²

8 SIMAP similar genes for LIPC using alignment to 5 protein entries: LIPC_HUMAN (see all proteins):

LIPH LPL LIPG PNLIPRP3 PNLIP PNLIPRP2

PLA1A PNLIPRP1

LIPC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: LIPC_HUMAN, P11150

Polymorphism: Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus

12 (HDLCQ12) [MIM:612797]

Polymorphism: Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility

(NIDDM susceptibility) [MIM:125853]

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121912502^1,2	C,F	pathogenic	58840586(+)	`CGACTC/TCTTGC`	2	S F	mis¹		2		NA EU	5875
rs113298164^1,2	C,F	pathogenic	58855748(+)	`TATCAC/TGCTGG`	2	T M	mis¹		3		NA EU	5995
rs583662^1,2	C,F,A,H	--	58722276(+)	`TGCCCA/GCTTAA`	1	--	us2k¹		16		NS EA NA WA CSA	793
rs184505819^1,2		--	58722308(+)	`GAGCCA/TTCTCA`	1	--	us2k¹		0	--	--	--	--
rs187679432^1,2		--	58722366(+)	`CTGCTC/TCACTC`	1	--	us2k¹		0	--	--	--	--
rs149736585^1,2		--	58722372(+)	`CACTCA/GCAGCT`	1	--	us2k¹		0	--	--	--	--
rs144691170^1,2		--	58722518(+)	`AATATA/TTCCAC`	1	--	us2k¹		0	--	--	--	--
rs192460974^1,2		--	58722541(+)	`ACTCCA/GCAGTT`	1	--	us2k¹		0	--	--	--	--
rs116372785^1,2		--	58722568(+)	`GGCCAC/TGCCAC`	1	--	us2k¹		1		WA	118
rs73420546^1,2	C	--	58722569(+)	`GCCACG/ACCACC`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for LIPC (58702768 - 58861151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LIPC
1 CNV: 66814
1 Indel: 11795
Human Gene Mutation Database (HGMD): LIPC

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIPC

DNA2.0 Custom Variant and Variant Library Synthesis for LIPC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LIPC for disorders           About GeneDecksing

OMIM gene information: 151670
OMIM disorders: 612797  125853
UniProtKB/Swiss-Prot: LIPC_HUMAN, P11150

Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency) [MIM:614025]. A disorder

characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low

and high density lipoproteins

20/82 diseases for LIPC (see all 82): About MalaCards

high density lipoprotein cholesterol level qtl 12 hepatitis diabetes mellitus, noninsulin-dependent hyperlipoproteinemia type iii

lipase deficiency combined benign recurrent intrahepatic cholestasis cleft lip/palate retinol binding protein

combined hyperlipemia polycystic ovary syndrome diabetes mellitus familial combined hyperlipidemia

hyperalphalipoproteinemia cleft lip hepatic lipase deficiency intrahepatic cholestasis

5 diseases from the University of Copenhagen DISEASES database for LIPC:

Familial hyperlipidemia Atherosclerosis Coronary heart disease Diabetes mellitus

Hypothyroidism

10/53 Novoseek disease relationships for LIPC gene (see all 53) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertriglyceridemia	84	37	2000816 (2), 8637399 (1), 11950708 (1), 12235167 (1) (see all 28)
hyperalphalipoproteinemia	81.5	5	19428034 (2), 10606208 (1), 18160998 (1), 9711993 (1)
hyperlipidemia familial combined	80.9	7	19069677 (1), 14709374 (1), 10606208 (1), 10894818 (1) (see all 5)
alphalipoproteinemia	79	1	15382513 (1)
lipase deficiency, combined	75.9	7	11714855 (2), 17994020 (1), 2025643 (1)
dyslipidemia	72.4	22	12843191 (2), 12639974 (2), 11171785 (1), 16338252 (1) (see all 14)
atherosclerosis	70.4	77	15205216 (6), 18599739 (4), 12235167 (3), 9645503 (3) (see all 35)
hypoalphalipoproteinemia	69.1	1	15292235 (1)
cetp deficiency	68.2	1	7583564 (1)
hyperlipoproteinemia type iii	67.9	1	10729390 (1)

Genatlas disease: LIPC

coronary atherosclerosis,premature,dyslipidemia

Genetic Association Database (GAD): LIPC
Human Genome Epidemiology (HuGE) Navigator: LIPC (205 documents)

Export disorders for LIPC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LIPC gene, integrated from 9 sources (see all 766):
(articles sorted by number of sources associating them with LIPC)

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The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study. (PubMed id 15126514)^{1, 2, 4, 9} Todorova B....Laakso M. (2004)
Effects of gender, hepatic lipase gene polymorphism and type 2 diabetes mellitus on hepatic lipase activity in Chinese. (PubMed id 11427226)^{1, 4, 9} Tan K.C....Chu B.Y. (2001)
Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant. (PubMed id 12547874)^{1, 4, 9} Berk-Planken I.I....Jansen H. (2003)
Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD. (PubMed id 12964943)^{1, 4, 9} Baroni M.G....Galton D.J. (2003)
Human hepatic lipase mutations and polymorphisms. (PubMed id 1301939)^{1, 2, 9} Hegele R.A.... Connelly P.W. (1992)
Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms. (PubMed id 14657196)^{1, 4, 9} Carr M.C....Deeb S.S. (2004)
Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC). (PubMed id 11968086)^{1, 4, 9} Shohet R.V....Cohen J.C. (2002)
A novel allele in the promoter of the hepatic lipase is associated with increased concentration of HDL-C and decreased promoter activity. (PubMed id 12364543)^{1, 4, 9} Su Z....Xiao C. (2002)
Interaction effect of Serine447Stop variant of the lipoprotein lipase gene and C-514T variant of the hepatic lipase gene on serum triglyceride levels in young adults: the Bogalusa Heart Study. (PubMed id 14564687)^{1, 4, 9} Xin X....Berenson G.S. (2003)
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. (PubMed id 18364377)^{1, 2, 9} Grarup N....Pedersen O. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3990	HGNC: 6619	AceView: LIPC	Ensembl:ENSG00000166035	euGenes: HUgn3990
ECgene: LIPC	Kegg: 3990	H-InvDB: LIPC

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LIPC	Pharmacogenomics, SNPs, Pathways
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LIPC

Intellectual Property for LIPC gene
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Patent Information for LIPC gene:
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Hypoalphalipoproteinemia
Fatty Liver
Hyperinsulinemia
HYPERALPHALIPOPROTEINEMIA
Bacterial Infections
Hyperlipidemia
Hypothyroidism
Hypertriglyceridemias Familial
insulin sensitivity
Myocardial Ischemia
Liver diseases
Atherosclerosis
Hyperlipoproteinemia
Hypercholesterolemia
Cholestasis
HEPATOCELLULAR CARCINOMA
Coronary Stenosis
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CETP DEFICIENCY
Diabetes Mellitus Insulin-Dependent
Uremia
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dyslipoproteinemia
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Hyperlipidemia Familial Combined
Coronary Artery Disease
Dyslipidemia
RENAL DISEASE
Heart Diseases
Insulin Resistance
impaired glucose tolerance
Inflammation
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Diabetic Nephropathies
OBESITY
Polycystic Ovary Syndrome
Hyperglycemia
ALPHALIPOPROTEINEMIA
Hyperlipoproteinemia Type III
Hepatitis C Chronic
STROKE
Renal Failure
Vascular Diseases
Cardiovascular Diseases
Tumors
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LIPASE DEFICIENCY, COMBINED
Hypercholesterolemia Familial
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LIPC Gene

lipase, hepatic

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