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Aliases for LIPC Gene

Aliases for LIPC Gene

  • Lipase C, Hepatic Type 2 3
  • Lipase, Hepatic 2 3 5
  • Triacylglycerol Lipase 2 3
  • Lipase Member C 3 4
  • Hepatic Lipase 3 4
  • EC 3.1.1.3 4 63
  • HTGL 3 4
  • HL 3 4
  • EC 3.1.1 63
  • HDLCQ12 3
  • LIPH 3

External Ids for LIPC Gene

Previous GeneCards Identifiers for LIPC Gene

  • GC15P054281
  • GC15P051771
  • GC15P056303
  • GC15P056440
  • GC15P056511
  • GC15P058702
  • GC15P035548

Summaries for LIPC Gene

Entrez Gene Summary for LIPC Gene

  • LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIPC Gene

LIPC (Lipase C, Hepatic Type) is a Protein Coding gene. Diseases associated with LIPC include hepatic lipase deficiency and diabetes mellitus, noninsulin-dependent. Among its related pathways are triacylglycerol biosynthesis and Metabolism. GO annotations related to this gene include heparin binding and phospholipase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for LIPC Gene

  • Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Gene Wiki entry for LIPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIPC Gene

Genomics for LIPC Gene

Regulatory Elements for LIPC Gene

Enhancers for LIPC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIPC on UCSC Golden Path with GeneCards custom track

Promoters for LIPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIPC on UCSC Golden Path with GeneCards custom track

Genomic Location for LIPC Gene

Chromosome:
15
Start:
58,410,569 bp from pter
End:
58,569,843 bp from pter
Size:
159,275 bases
Orientation:
Plus strand

Genomic View for LIPC Gene

Genes around LIPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIPC Gene

Proteins for LIPC Gene

  • Protein details for LIPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11150-LIPC_HUMAN
    Recommended name:
    Hepatic triacylglycerol lipase
    Protein Accession:
    P11150
    Secondary Accessions:
    • A2RUB4
    • A8K9B6
    • O43571
    • P78529
    • Q99465

    Protein attributes for LIPC Gene

    Size:
    499 amino acids
    Molecular mass:
    55914 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LIPC Gene

Proteomics data for LIPC Gene at MOPED

Post-translational modifications for LIPC Gene

  • Glycosylation at Asn 42, Asn 78, Asn 362, and Asn 397
  • Modification sites at PhosphoSitePlus

Other Protein References for LIPC Gene

Domains & Families for LIPC Gene

Gene Families for LIPC Gene

Suggested Antigen Peptide Sequences for LIPC Gene

Graphical View of Domain Structure for InterPro Entry

P11150

UniProtKB/Swiss-Prot:

LIPC_HUMAN :
  • Contains 1 PLAT domain.
  • Belongs to the AB hydrolase superfamily. Lipase family.
Domain:
  • Contains 1 PLAT domain.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with LIPC: view

Function for LIPC Gene

Molecular function for LIPC Gene

GENATLAS Biochemistry:
lipase,hepatic,53kDa,plasma lipid transport
UniProtKB/Swiss-Prot CatalyticActivity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Enzyme Numbers (IUBMB) for LIPC Gene

Gene Ontology (GO) - Molecular Function for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008201 heparin binding IEA --
GO:0008289 lipid binding IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with LIPC: view
genes like me logo Genes that share phenotypes with LIPC: view

Human Phenotype Ontology for LIPC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LIPC Gene

MGI Knock Outs for LIPC:

Animal Model Products

miRNA for LIPC Gene

miRTarBase miRNAs that target LIPC

No data available for Transcription Factor Targets and HOMER Transcription for LIPC Gene

Localization for LIPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIPC Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIPC Gene COMPARTMENTS Subcellular localization image for LIPC gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
endosome 2
cytoskeleton 1
cytosol 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005902 microvillus IEA --
genes like me logo Genes that share ontologies with LIPC: view

Pathways & Interactions for LIPC Gene

genes like me logo Genes that share pathways with LIPC: view

Gene Ontology (GO) - Biological Process for LIPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IDA 182536
GO:0006641 triglyceride metabolic process IEA --
GO:0006658 phosphatidylserine metabolic process IEA --
genes like me logo Genes that share ontologies with LIPC: view

No data available for SIGNOR curated interactions for LIPC Gene

Drugs & Compounds for LIPC Gene

(44) Drugs for LIPC Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluvastatin Approved Pharma Competitive, Inhibitor 58
Pravastatin Approved Pharma Competitive, Inhibitor 145
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 499
arachidonic acid Experimental Nutra Activator 27
MYRISTIC ACID Experimental Pharma 0

(74) Additional Compounds for LIPC Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LIPC: view

Transcripts for LIPC Gene

Unigene Clusters for LIPC Gene

Lipase, hepatic:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIPC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1:
SP2:
SP3: - - - -
SP4: - - -
SP5:

Relevant External Links for LIPC Gene

GeneLoc Exon Structure for
LIPC
ECgene alternative splicing isoforms for
LIPC

Expression for LIPC Gene

mRNA expression in normal human tissues for LIPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIPC Gene

This gene is overexpressed in Liver (x39.0).

Protein differential expression in normal tissues from HIPED for LIPC Gene

This gene is overexpressed in Colon muscle (39.7), Platelet (11.3), Liver (9.4), and Fetal Liver (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIPC Gene



SOURCE GeneReport for Unigene cluster for LIPC Gene Hs.654472

genes like me logo Genes that share expression patterns with LIPC: view

Protein tissue co-expression partners for LIPC Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LIPC Gene

Orthologs for LIPC Gene

This gene was present in the common ancestor of animals.

Orthologs for LIPC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIPC 35
  • 84.48 (n)
  • 77.82 (a)
LIPC 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIPC 35
  • 85.82 (n)
  • 79.03 (a)
HTGL 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lipc 35
  • 80.5 (n)
  • 76.48 (a)
Lipc 16
Lipc 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIPC 35
  • 99.13 (n)
  • 98.8 (a)
LIPC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lipc 35
  • 80.56 (n)
  • 75.77 (a)
oppossum
(Monodelphis domestica)
Mammalia LIPC 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIPC 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIPC 35
  • 67.76 (n)
  • 64.75 (a)
LIPC 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIPC 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lipc 35
  • 62.04 (n)
  • 58.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17530 35
zebrafish
(Danio rerio)
Actinopterygii lipca 35
  • 60.64 (n)
  • 54.47 (a)
zgc64081 35
lipca 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6472 37
  • 33 (a)
CG6847 37
  • 37 (a)
CG5966 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for LIPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIPC Gene

ENSEMBL:
Gene Tree for LIPC (if available)
TreeFam:
Gene Tree for LIPC (if available)

Paralogs for LIPC Gene

Paralogs for LIPC Gene

(7) SIMAP similar genes for LIPC Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LIPC: view

Variants for LIPC Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LIPC Gene

P11150-LIPC_HUMAN
Genetic variations in LIPC are associated with non-insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIM:125853].

Sequence variations from dbSNP and Humsavar for LIPC Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs6078 - 58,541,794(+) ACGGC(A/G/T)TGCTA reference, missense
rs6083 - 58,545,811(+) TGCCA(A/G)TTTTG reference, missense
rs121912502 Hepatic lipase deficiency (HL deficiency) 58,548,387(+) CGACT(C/T)CTTGC reference, missense
rs113298164 Hepatic lipase deficiency (HL deficiency) 58,563,549(+) TATCA(C/T)GCTGG reference, missense
rs6079 - 58,563,654(+) ATGGA(A/G)CACAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LIPC Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv904267 CNV Gain 21882294
nsv524065 CNV Loss 19592680
nsv904268 CNV Gain 21882294
esv259952 OTHER Complex 20981092
nsv827345 CNV Gain 20364138
esv25142 CNV Gain 19812545
nsv524098 CNV Loss 19592680
nsv522373 CNV Loss 19592680
nsv94680 CNV Loss 16902084
esv1002236 CNV Gain 20482838

Variation tolerance for LIPC Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIPC Gene

HapMap Linkage Disequilibrium report
LIPC
Human Gene Mutation Database (HGMD)
LIPC

Disorders for LIPC Gene

MalaCards: The human disease database

(21) MalaCards diseases for LIPC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatic lipase deficiency
  • lipase, hepatic
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
hyperalphalipoproteinemia
  • cholesterol-ester transfer protein deficiency
atherosclerosis
  • arteriosclerosis
lipase deficiency, combined
  • cld
- elite association - COSMIC cancer census association via MalaCards
Search LIPC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LIPC_HUMAN
  • Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. {ECO:0000269 PubMed:10660332, ECO:0000269 PubMed:1301939}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for LIPC Gene

coronary atherosclerosis,premature,dyslipidemia

Relevant External Links for LIPC

Genetic Association Database (GAD)
LIPC
Human Genome Epidemiology (HuGE) Navigator
LIPC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIPC
genes like me logo Genes that share disorders with LIPC: view

Publications for LIPC Gene

  1. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. (PMID: 18364377) Grarup N. … Pedersen O. (J. Clin. Endocrinol. Metab. 2008) 3 4 23 48 67
  2. Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. (PMID: 19489872) Lamon-Fava S. … Herrington D.M. (Clin. Endocrinol. (Oxf) 2010) 3 23
  3. Association of LIPC -250G>A polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. (PMID: 20222961) Meng L. … Shangling P. (Lipids Health Dis 2010) 3 23
  4. Hepatic lipase maturation: a partial proteome of interacting factors. (PMID: 19136429) Doolittle M.H. … Wong H. (J. Lipid Res. 2009) 3 23
  5. HDL-ApoE content regulates the displacement of hepatic lipase from cell surface proteoglycans. (PMID: 19528346) Young E.K. … Sparks D.L. (Am. J. Pathol. 2009) 3 23

Products for LIPC Gene

Sources for LIPC Gene

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