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LINGO1 Gene

protein-coding   GIFtS: 60
GCID: GC15M077905

Leucine Rich Repeat And Ig Domain Containing 1

(Previous name: leucine rich repeat neuronal 6A)
(Previous symbol: LRRN6A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat And Ig Domain Containing 11 2     Leucine-Rich Repeat Neuronal Protein 12 3
LRRN6A1 2 3 5     Leucine-Rich Repeat Neuronal Protein 6A2 3
LERN12 3 5     UNQ2012
Leucine Rich Repeat Neuronal 6A1 2     Leucine-Rich Repeat And Immunoglobilin Domain-Containing Protein 12
Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 12 3     Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo
Receptor-Interacting Protein 12

External Ids:    HGNC: 212051   Entrez Gene: 848942   Ensembl: ENSG000001697837   OMIM: 6097915   UniProtKB: Q96FE53   

Export aliases for LINGO1 gene to outside databases

Previous GC identifers: GC15M075694 GC15M054660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LINGO1 Gene:
LINGO1 (leucine rich repeat and Ig domain containing 1) is a protein-coding gene. GO annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LRFN3.

UniProtKB/Swiss-Prot: LIGO1_HUMAN, Q96FE5
Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible
for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator
of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating
neuronal precursor cell motility during cortical development (By similarity)

Gene Wiki entry for LINGO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LINGO1 gene promoter:
         Egr-3   SRF   C/EBPbeta   AP-1   SRF (504 AA)   RelA   CUTL1   Gfi-1   S8   CP2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLINGO1 promoter sequence
   Search Chromatin IP Primers for LINGO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LINGO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24

LINGO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LINGO1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M077905:  view genomic region     (about GC identifiers)

Start:
77,905,369 bp from pter      End:
78,113,242 bp from pter
Size:
207,874 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIGO1_HUMAN, Q96FE5 (See protein sequence)
Recommended Name: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
1 precursor  
Size: 620 amino acids; 69876 Da
Subunit: Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19
1 PDB 3D structure from and Proteopedia for LINGO1:
2ID5 (3D)    
Secondary accessions: D3DW80 Q6NUK3 Q6UXM3 Q6VVG0 Q6VVG1 Q6VVG2 Q8N3K5 Q96K52
Alternative splicing: 2 isoforms:  Q96FE5-1   Q96FE5-2   

Explore the universe of human proteins at neXtProt for LINGO1: NX_Q96FE5

Explore proteomics data for LINGO1 at MOPED

Post-translational modifications: 

  • N-glycosylated. Contains predominantly high-mannose glycans1
  • Glycosylation2 at Asn144, Asn202, Asn264, Asn274, Asn293, Asn341, Asn492, Asn505, Asn526, Asn542
  • Modification sites at PhosphoSitePlus

  • See LINGO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116197.4  
    ENSEMBL proteins: 
     ENSP00000347451   ENSP00000453853   ENSP00000453780   ENSP00000455605   ENSP00000454465  
     ENSP00000454687   ENSP00000454051   ENSP00000454245   ENSP00000454577   ENSP00000456516  
     ENSP00000457101  
    Reactome Protein details: Q96FE5

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    Cloud-Clone Corp. Proteins for LINGO1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q96FE5

    ProtoNet protein and cluster: Q96FE5

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: LIGO1_HUMAN, Q96FE5
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with LINGO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIGO1_HUMAN, Q96FE5
    Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible
    for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator
    of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating
    neuronal precursor cell motility during cortical development (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LINGO1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LINGO1:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lingo1):
     nervous system 

    Find genes that share phenotypes with LINGO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lingo1tm1Shmi for LINGO1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LINGO1
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    hsa-let-7d hsa-miR-765 hsa-let-7a-2* hsa-let-7g hsa-miR-183* hsa-let-7a hsa-miR-520g hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidLINGO1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIGO1_HUMAN, Q96FE5: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LINGO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LINGO1 About    
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    Axonal growth inhibition (RHOA activation)0.00
    p75NTR regulates axonogenesis0.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    5BDNF signaling pathway
    BDNF signaling pathway


    Find genes that share SuperPaths with LINGO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for LINGO1
        Development MAG-dependent inhibition of neurite outgrowth

    1 BioSystems Pathway for LINGO1
        BDNF signaling pathway

    1 Reactome Pathway for LINGO1
        Axonal growth inhibition (RHOA activation)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LINGO1
    Interactions:

        Search GeneGlobe Interaction Network for LINGO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for LINGO1 (Q96FE52, 3 ENSP000003474514) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFEMP2O959672, 3, ENSP000003099534MINT-67217 I2D: score=4 STRING: ENSP00000309953
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-68288 I2D: score=5 STRING: ENSP00000377582
    FBXW7Q969H02, 3, ENSP000002817084MINT-64690 I2D: score=5 STRING: ENSP00000281708
    NGFRP081383, ENSP000001722294I2D: score=2 STRING: ENSP00000172229
    RTN4RQ9BZR63, ENSP000000434024I2D: score=2 STRING: ENSP00000043402
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021954central nervous system neuron development IEA--
    GO:0031175neuron projection development IEA--
    GO:0043491protein kinase B signaling IEA--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0048715negative regulation of oligodendrocyte differentiation IEA--

    Find genes that share ontologies with LINGO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LINGO1 (LIGO1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LINGO1 gene: 
    NM_032808.5  

    Unigene Cluster for LINGO1:

    Leucine rich repeat and Ig domain containing 1
    Hs.656765  [show with all ESTs]
    Unigene Representative Sequence: AY324320
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355300(uc002bct.1 uc002bcu.1) ENST00000561030 ENST00000557798
    ENST00000561686 ENST00000567726 ENST00000566711 ENST00000559893 ENST00000564472
    ENST00000570216 ENST00000562933 ENST00000563316 ENST00000567605 ENST00000568951
    ENST00000564066
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LINGO1 (see all 38):
    hsa-let-7d hsa-miR-765 hsa-let-7a-2* hsa-let-7g hsa-miR-183* hsa-let-7a hsa-miR-520g hsa-miR-3173-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat LINGO1
      QuantiFast Probe-based Assays in human, mouse, rat LINGO1

    Additional mRNA sequence: 

    AK027500.1 AK291363.1 AL109677.1 AL834260.1 AY324320.1 AY324322.1 AY324323.1 AY358284.1 
    BC011057.1 

    4 DOTS entries:

    DT.113424  DT.97784638  DT.92418476  DT.92418478 

    Selected AceView cDNA sequences (see all 87):

    BI914769 AL109677 BC011057 AI253116 BU157953 CR603375 AY324323 CD672335 
    BG056899 BF970344 CR603492 BM547778 NM_032808 AK027500 F04762 BM710888 
    BM698280 BM696237 BI917385 BI825536 BI669707 AY324322 AI870535 AA503379 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LINGO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATGATAT
    LINGO1 Expression
    About this image


    LINGO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Spinal Cord (Nervous System)
    LINGO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LINGO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656765

    UniProtKB/Swiss-Prot: LIGO1_HUMAN, Q96FE5
    Tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala,
    hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always
    present. Up-regulated in substantia nigra neurons from Parkinson disease patients

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LINGO1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lingo11 , 5 leucine rich repeat and Ig domain containing 11, 5 92.07(n)1
    99.35(a)1
      9 (30.28 cM)5
    2354021  NM_181074.41  NP_851419.11 
     566184755 
    chicken
    (Gallus gallus)
    Aves LINGO11 leucine rich repeat and Ig domain containing 1 84.28(n)
    92.82(a)
      415344  NM_001024577.1  NP_001019748.1 
    lizard
    (Anolis carolinensis)
    Reptilia LINGO16
    leucine rich repeat and Ig domain containing 1
    90(a)
    1 ↔ 1
    GL343374.1(603075-655813)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lingo11 leucine rich repeat and Ig domain containing 1 73.98(n)
    84.55(a)
      100101739  NM_001100249.1  NP_001093719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.129032 Transcribed sequence with weak similarity to protein more 76.24(n)    57096888 


    ENSEMBL Gene Tree for LINGO1 (if available)
    TreeFam Gene Tree for LINGO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LINGO1 gene
    LRFN32  LRRN32  LRRC42  LRFN42  LINGO22  LRRC4B2  LRRN12  LRFN52  
    LRFN22  LRRC4C2  LRFN12  LINGO32  LRRN22  LINGO42  
    9 SIMAP similar genes for LINGO1 using alignment to 9 protein entries:     LIGO1_HUMAN (see all proteins):
    LINGO2    LINGO3    LINGO4    SLIT2    LRRC4B    LRRC32
    LRRC4    LGR4    ISLR2

    Find genes that share paralogs with LINGO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LINGO1 (see all 517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513052961,2
    C--54682183(+) ATGTC-/ATATGC 1 -- us2k10--------
    rs1156967641,2
    F--54682228(+) TAGCAG/AGCGTC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1832140011,2
    --54682234(+) GCGTCC/TATGCT 1 -- us2k10--------
    rs133293231,2
    C,F--54682256(+) TGAACT/GGTACG 1 -- us2k18Minor allele frequency- G:0.22NA WA CSA EA 367
    rs800541681,2
    F--77904914(+) ACTGCC/TTCTCC 1 -- ds50010--------
    rs125911101,2
    C,F,A,H--77904944(+) ACTCTA/GCATGG 1 -- ds500126Minor allele frequency- N:0.00EA NA NS WA CSA 2565
    rs1858025621,2
    --77904996(+) AAGGCC/TTGGGG 1 -- ds50010--------
    rs98061391,2
    C,F,H--77905024(+) TCCTTG/ACATCA 1 -- ds500118Minor allele frequency- A:0.16NS EA NA CSA WA 2338
    rs734578151,2
    C,F--77905152(+) TCTCTA/GTGCCC 1 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1462723781,2
    --77905482(+) TTGTAC/GAGATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LINGO1 (77905369 - 78113242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LINGO1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4114CNV Deletion18987735
    esv2569789CNV Deletion19546169
    esv996097CNV Deletion20482838
    esv2102930CNV Deletion18987734
    esv2749908CNV Deletion23290073
    esv1355090CNV Deletion17803354
    esv2749898CNV Deletion23290073
    esv270080CNV Insertion20981092
    esv25321CNV Loss19812545
    nsv512407CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 609791    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for LINGO1:
    Essential tremor

    Find genes that share disorders with LINGO1           About GenesLikeMe

    Genetic Association Database (GAD): LINGO1
    Human Genome Epidemiology (HuGE) Navigator: LINGO1 (14 documents)

    Export disorders for LINGO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LINGO1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with LINGO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. (PubMed id 14686891)1, 2, 3, 9 Carim-Todd L.... Sumoy L. (Eur. J. Neurosci. 2003)
    2. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. (PubMed id 20369371)1, 4 VilariA+o-GA1ell C....Farrer M.J. (Neurogenetics 2010)
    3. Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis. (PubMed id 20117178)1, 4 BiaA8ecka M....Drozdzik M. (Neurosci. Lett. 2010)
    4. LINGO1 polymorphisms are associated with essential tremor in Europeans. (PubMed id 20310002)1, 4 Thier S....Klebe S. (Mov. Disord. 2010)
    5. LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. (PubMed id 19720553)1, 4 VilariA+o-GA1ell C....Farrer M.J. (amp 2010)
    6. LINGO1 is not associated with Parkinson's disease in German patients. (PubMed id 20468067)1, 4 Klebe S....KuhlenbAoumer G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Replication of the LINGO1 gene association with essential tremor in a North American population. (PubMed id 20372186)1, 4 Clark L.N....Louis E.D. (Eur. J. Hum. Genet. 2010)
    8. Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population. (PubMed id 20600614)1, 4 Zuo X....Tang B.S. (Neurosci. Lett. 2010)
    9. Role of LINGO1 polymorphisms in Parkinson's disease. (PubMed id 19908305)1, 4 Haubenberger D....Zimprich A. (Mov. Disord. 2009)
    10. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. (PubMed id 19182806)1, 4 Stefansson H....Stefansson K. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84894 HGNC: 21205 AceView: LRRN6A Ensembl:ENSG00000169783 euGenes: HUgn84894
    ECgene: LINGO1 H-InvDB: LINGO1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LINGO1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LINGO1 gene:
    Search GeneIP for patents involving LINGO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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