Aliases for LINGO1 Gene
External Ids for LINGO1 Gene
Previous HGNC Symbols for LINGO1 Gene
Previous GeneCards Identifiers for LINGO1 Gene
GeneCards Summary for LINGO1 Gene
LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a Protein Coding gene. Diseases associated with LINGO1 include essential tremor and movement disease. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LRFN3.
UniProtKB/Swiss-Prot for LINGO1 Gene
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).