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Aliases for LINGO1 Gene

Aliases for LINGO1 Gene

  • Leucine Rich Repeat And Ig Domain Containing 1 2 3
  • LRRN6A 3 4 6
  • Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 3 4
  • Leucine-Rich Repeat Neuronal Protein 1 3 4
  • Leucine Rich Repeat Neuronal 6A 2 3
  • LERN1 3 4
  • Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 3
  • Leucine-Rich Repeat Neuronal Protein 6A 4
  • UNQ201 3
  • LERN1, 6

External Ids for LINGO1 Gene

Previous Symbols for LINGO1 Gene

  • LRRN6A

Summaries for LINGO1 Gene

GeneCards Summary for LINGO1 Gene

LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LINGO3.

UniProtKB/Swiss-Prot for LINGO1 Gene

  • Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).

Gene Wiki entry for LINGO1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LINGO1 Gene

Genomics for LINGO1 Gene

Genomic Location for LINGO1 Gene

Start:
77,613,027 bp from pter
End:
77,820,900 bp from pter
Size:
207,874 bases
Orientation:
Minus strand

Genomic View for LINGO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LINGO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LINGO1 Gene

Regulatory Elements for LINGO1 Gene

Proteins for LINGO1 Gene

  • Protein details for LINGO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FE5-LIGO1_HUMAN
    Recommended name:
    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    Protein Accession:
    Q96FE5
    Secondary Accessions:
    • D3DW80
    • Q6NUK3
    • Q6UXM3
    • Q6VVG0
    • Q6VVG1
    • Q6VVG2
    • Q8N3K5
    • Q96K52

    Protein attributes for LINGO1 Gene

    Size:
    620 amino acids
    Molecular mass:
    69876 Da
    Quaternary structure:
    • Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19.

    Three dimensional structures from OCA and Proteopedia for LINGO1 Gene

    Alternative splice isoforms for LINGO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LINGO1 Gene

Proteomics data for LINGO1 Gene at MOPED

Post-translational modifications for LINGO1 Gene

  • N-glycosylated. Contains predominantly high-mannose glycans.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn144, Asn202, Asn264, Asn274, Asn293, Asn341, Asn492, Asn505, Asn526, and Asn542

No data available for DME Specific Peptides for LINGO1 Gene

Domains for LINGO1 Gene

Gene Families for LINGO1 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

UniProtKB/Swiss-Prot:

LIGO1_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q96FE5
  • Contains 1 LRRCT domain.:
    • Q96FE5
  • Contains 1 LRRNT domain.:
    • Q96FE5
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.:
    • Q96FE5
genes like me logo Genes that share domains with LINGO1: view

Function for LINGO1 Gene

Molecular function for LINGO1 Gene

UniProtKB/Swiss-Prot Function: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).

Gene Ontology (GO) - Molecular Function for LINGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LINGO1: view

Phenotypes for LINGO1 Gene

genes like me logo Genes that share phenotypes with LINGO1: view

Animal Models for LINGO1 Gene

MGI Knock Outs for LINGO1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LINGO1 Gene

Localization for LINGO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LINGO1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LINGO1 Gene COMPARTMENTS Subcellular localization image for LINGO1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LINGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LINGO1: view

Pathways for LINGO1 Gene

genes like me logo Genes that share pathways with LINGO1: view

Pathways by source for LINGO1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for LINGO1 Gene
1 BioSystems pathway for LINGO1 Gene

Gene Ontology (GO) - Biological Process for LINGO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021954 central nervous system neuron development IEA --
GO:0031175 neuron projection development IEA --
GO:0043491 protein kinase B signaling IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
GO:0048715 negative regulation of oligodendrocyte differentiation IEA --
genes like me logo Genes that share ontologies with LINGO1: view

Transcripts for LINGO1 Gene

Unigene Clusters for LINGO1 Gene

Leucine rich repeat and Ig domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LINGO1 Gene

No ASD Table

Relevant External Links for LINGO1 Gene

GeneLoc Exon Structure for
LINGO1
ECgene alternative splicing isoforms for
LINGO1

Expression for LINGO1 Gene

mRNA expression in normal human tissues for LINGO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LINGO1 Gene

This gene is overexpressed in Brain - Cortex (9.2), Brain - Frontal Cortex (BA9) (7.3), Brain - Anterior cingulate cortex (BA24) (7.0), Brain - Hippocampus (5.7), and Brain - Amygdala (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LINGO1 Gene

SOURCE GeneReport for Unigene cluster for LINGO1 Gene Hs.656765

mRNA Expression by UniProt/SwissProt for LINGO1 Gene

Q96FE5-LIGO1_HUMAN
Tissue specificity: Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
genes like me logo Genes that share expressions with LINGO1: view

Orthologs for LINGO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LINGO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LINGO1 36
  • 99.73 (n)
  • 100 (a)
LINGO1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LINGO1 36
  • 95.16 (n)
  • 99.52 (a)
LINGO1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LINGO1 36
  • 94.84 (n)
  • 98.71 (a)
LINGO1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lingo1 36
  • 92.07 (n)
  • 99.35 (a)
Lingo1 16
Lingo1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LINGO1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LINGO1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lingo1 36
  • 92.04 (n)
  • 99.19 (a)
chicken
(Gallus gallus)
Aves LINGO1 36
  • 84.28 (n)
  • 92.82 (a)
LINGO1 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LINGO1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lingo1 36
  • 73.98 (n)
  • 84.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12903 36
lingo1a 36
  • 74.23 (n)
  • 81.89 (a)
lingo1a 37
  • 81 (a)
OneToMany
lingo1b 37
  • 72 (a)
OneToMany
Species with no ortholog for LINGO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LINGO1 Gene

ENSEMBL:
Gene Tree for LINGO1 (if available)
TreeFam:
Gene Tree for LINGO1 (if available)

Paralogs for LINGO1 Gene

genes like me logo Genes that share paralogs with LINGO1: view

Variants for LINGO1 Gene

Sequence variations from dbSNP and Humsavar for LINGO1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3144 -- 77,613,862(+) GGTCC(C/T)GGTAG utr-variant-3-prime
rs9855 - 77,615,359(-) CATCT(C/T)TCACC reference, missense
rs875035 -- 77,634,746(+) CCCCT(C/T)CCCAG intron-variant
rs883669 -- 77,617,753(-) TGTGG(A/G)CAGAC intron-variant
rs907394 -- 77,617,021(+) CAGGA(C/T)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LINGO1 Gene

Variant ID Type Subtype PubMed ID
esv2749898 CNV Deletion 23290073
nsv833060 CNV Gain 17160897
dgv2421n71 CNV Loss 21882294
dgv2422n71 CNV Loss 21882294
nsv904419 CNV Loss 21882294
esv2569789 CNV Deletion 19546169
nsv512407 CNV Loss 21212237
esv2102930 CNV Deletion 18987734
esv4114 CNV Deletion 18987735
esv2749908 CNV Deletion 23290073
esv996097 CNV Deletion 20482838
nsv94941 CNV Loss 16902084
esv9490 CNV Loss 19470904
esv1355090 CNV Deletion 17803354
esv270080 CNV Insertion 20981092
esv25321 CNV Loss 19812545

Relevant External Links for LINGO1 Gene

HapMap Linkage Disequilibrium report
LINGO1

Disorders for LINGO1 Gene

(1) University of Copenhagen DISEASES for LINGO1 Gene

Relevant External Links for LINGO1

Genetic Association Database (GAD)
LINGO1
Human Genome Epidemiology (HuGE) Navigator
LINGO1
genes like me logo Genes that share disorders with LINGO1: view

No data available for UniProtKB/Swiss-Prot for LINGO1 Gene

Publications for LINGO1 Gene

  1. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. (PMID: 14686891) Carim-Todd L. … Sumoy L. (Eur. J. Neurosci. 2003) 2 3 4 23
  2. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PMID: 15694321) Park J.B. … He Z. (Neuron 2005) 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. (PMID: 14966521) Mi S. … Pepinsky R.B. (Nat. Neurosci. 2004) 3 4

Products for LINGO1 Gene

Sources for LINGO1 Gene

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