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LINC01587 Gene(RNA Gene)

Long Intergenic Non-Protein Coding RNA 1587

GCID:
GC04P005524
GIFtS:
28
Genes Participants
UDN Logo

Aliases for LINC01587 Gene

Subcategory (RNA class) for LINC01587 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for LINC01587 Gene

  • Long Intergenic Non-Protein Coding RNA 1587 2 3 5
  • C4orf6 3 4
  • AC1 3 4
  • Chromosome 4 Open Reading Frame 6 2
  • Expressed In Neuroblastoma 3
  • Protein AC1 4

External Ids for LINC01587 Gene

Previous HGNC Symbols for LINC01587 Gene

  • C4orf6

Summaries for LINC01587 Gene

Entrez Gene Summary for LINC01587 Gene

  • This gene is expressed in neuroblastoma; however, the function of this gene is not yet determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for LINC01587 Gene

LINC01587 (Long Intergenic Non-Protein Coding RNA 1587) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with LINC01587 include Neuroblastoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LINC01587 Gene

Genomics for LINC01587 Gene

Products:

  1. Regulatory Element

Regulatory Elements for LINC01587 Gene

Enhancers for LINC01587 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F005524 0.8 Ensembl ENCODE 0.8 +0.6 565 1.6 ELK4 ELK1 POLR2A HNF4G WT1 RAD21 NR2F2 WFS1 GC04P005525 LINC01587
GH04F005504 0.2 ENCODE 0.3 -20.0 -19970 0.1 LINC01587 GC04M005485
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LINC01587 on UCSC Golden Path with GeneCards custom track

Genomic Location for LINC01587 Gene

Chromosome:
4
Start:
5,524,569 bp from pter
End:
5,527,801 bp from pter
Size:
3,233 bases
Orientation:
Plus strand

Genomic View for LINC01587 Gene

Genes around LINC01587 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LINC01587 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LINC01587 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LINC01587 Gene

Proteins for LINC01587 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LINC01587 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99440-CD006_HUMAN
    Recommended name:
    Uncharacterized protein encoded by LINC01587
    Protein Accession:
    Q99440
    Secondary Accessions:
    • Q17R65

    Protein attributes for LINC01587 Gene

    Size:
    93 amino acids
    Molecular mass:
    10499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LINC01587 Gene

Post-translational modifications for LINC01587 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LINC01587 Gene

Domains & Families for LINC01587 Gene

Protein Domains for LINC01587 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LINC01587 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LINC01587: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LINC01587 Gene

Function for LINC01587 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for LINC01587 Gene

GenomeRNAi human phenotypes for LINC01587:
genes like me logo Genes that share phenotypes with LINC01587: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC01587 Gene

Localization for LINC01587 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LINC01587 gene
Compartment Confidence
extracellular 2
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LINC01587 Gene

Pathways & Interactions for LINC01587 Gene

SuperPathways for LINC01587 Gene

PathCards logo More details on SuperPathways for LINC01587
No Data Available

Interacting Proteins for LINC01587 Gene

Gene Ontology (GO) - Biological Process for LINC01587 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9016955
genes like me logo Genes that share ontologies with LINC01587: view

No data available for Pathways by source and SIGNOR curated interactions for LINC01587 Gene

Drugs & Compounds for LINC01587 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LINC01587 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for LINC01587 Gene

(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LINC01587 Gene

No ASD Table

Relevant External Links for LINC01587 Gene

GeneLoc Exon Structure for
LINC01587
ECgene alternative splicing isoforms for
LINC01587

Expression for LINC01587 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LINC01587 Gene

mRNA expression in normal human tissues for LINC01587 Gene
mRNA expression by GTEx for LINC01587 Gene

NURSA nuclear receptor signaling pathways regulating expression of LINC01587 Gene:

LINC01587

mRNA Expression by UniProt/SwissProt for LINC01587 Gene:

Q99440-CD006_HUMAN
Tissue specificity: Expressed in neuroblastoma.
genes like me logo Genes that share expression patterns with LINC01587: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LINC01587 Gene

Orthologs for LINC01587 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LINC01587 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C4H4orf6 34
  • 99.28 (n)
Species where no ortholog for LINC01587 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LINC01587 Gene

ENSEMBL:
Gene Tree for LINC01587 (if available)
TreeFam:
Gene Tree for LINC01587 (if available)

Paralogs for LINC01587 Gene

No data available for Paralogs for LINC01587 Gene

Variants for LINC01587 Gene

Sequence variations from dbSNP and Humsavar for LINC01587 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10488938 -- 5,527,646(-) TCGTG(C/T)GGTGA nc-transcript-variant
rs1059157 -- 5,526,298(+) ACTGT(C/G)TCCGG nc-transcript-variant
rs1059158 -- 5,527,506(+) ACATG(A/T)CGAAA nc-transcript-variant
rs1059159 -- 5,527,507(+) CATGA(C/T)GAAAA nc-transcript-variant
rs112297665 -- 5,527,267(+) GTCCA(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LINC01587 Gene

Variant ID Type Subtype PubMed ID
nsv593480 CNV loss 21841781
nsv593482 CNV loss 21841781
nsv526713 CNV gain 19592680
nsv522680 CNV gain 19592680
nsv1005173 CNV gain 25217958
esv34196 OTHER inversion 12058347

Variation tolerance for LINC01587 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LINC01587 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LINC01587

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LINC01587 Gene

Disorders for LINC01587 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LINC01587 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LINC01587

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LINC01587
genes like me logo Genes that share disorders with LINC01587: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LINC01587 Gene

Publications for LINC01587 Gene

  1. Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (PMID: 9016955) Kito K. … Sakaki Y. (Gene 1997) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. (PMID: 18454448) Temtamy S.A. … Ruiz-Perez V.L. (Hum. Mutat. 2008) 3 64
  4. Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. (PMID: 16973907) Gros R. … Feldman R.D. (Circ. Res. 2006) 22 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for LINC01587 Gene

Sources for LINC01587 Gene

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