Aliases for LINC01587 Gene
Subcategory (RNA class) for LINC01587 Gene
non-coding RNA
Quality Score for this RNA gene is
3
Aliases for LINC01587 Gene
External Ids for LINC01587 Gene
- HGNC: 13716
- Entrez Gene: 10141
- Ensembl: ENSG00000082929
- UniProtKB: Q99440
Previous HGNC Symbols for LINC01587 Gene
- C4orf6
Summaries for LINC01587 Gene
-
This gene is expressed in neuroblastoma; however, the function of this gene is not yet determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for LINC01587 Gene
LINC01587 (Long Intergenic Non-Protein Coding RNA 1587) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with LINC01587 include Neuroblastoma.
Additional gene information for LINC01587 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LINC01587 Gene
Genomics for LINC01587 Gene
GeneHancer (GH) Regulatory Elements for LINC01587 Gene
Promoters and enhancers for LINC01587 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04I005524 | Enhancer | 0.7 | Ensembl ENCODE | 550.8 | +0.6 | 564 | 1.6 | ELK4 RXRA ELK1 POLR2A RCOR1 WT1 NR2F2 | GC04P005525 LINC01587 WFS1 | |
| GH04I005504 | Enhancer | 0.2 | ENCODE | 0.4 | -20.0 | -19970 | 0.1 | GC04M005485 LINC01587 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around LINC01587 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for LINC01587 Gene
Genomic Locations for LINC01587 Gene
- chr4:5,524,569-5,527,801
- (GRCh38/hg38)
- Size:
- 3,233 bases
- Orientation:
- Plus strand
- chr4:5,526,296-5,529,528
- (GRCh37/hg19)
Genomic View for LINC01587 Gene
Genes around LINC01587 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.2 by Ensembl
- 4p16.2 by Entrez Gene
- 4p16.2 by HGNC
LINC01587 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LINC01587 Gene
Proteins for LINC01587 Gene
-
Protein details for LINC01587 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99440-CD006_HUMAN
- Recommended name:
- Uncharacterized protein encoded by LINC01587
- Protein Accession:
- Q99440
- Q17R65
Protein attributes for LINC01587 Gene
- Size:
- 93 amino acids
- Molecular mass:
- 10499 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for LINC01587 Gene
No Post-translational modifications
Antibody Products
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- antibodies-online: Search results for 3 available C4orf6 Antibodies ranked by validation data
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-
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-
Quality Products:
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-
Abcam proteins for LINC01587
Assay Products
No data available for DME Specific Peptides for LINC01587 Gene
Domains & Families for LINC01587 Gene
Protein Domains for LINC01587 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for LINC01587 Gene
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Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for LINC01587 Gene
Function for LINC01587 Gene
Phenotypes for LINC01587 Gene
- GenomeRNAi human phenotypes for LINC01587:
Animal Model Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LINC01587 Gene
Localization for LINC01587 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| cytosol | 2 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LINC01587 Gene
Pathways & Interactions for LINC01587 Gene
No Data Available
Interacting Proteins for LINC01587 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007399 | nervous system development | TAS | 9016955 |
No data available for Pathways by source and SIGNOR curated interactions for LINC01587 Gene
Transcripts for LINC01587 Gene
mRNA/cDNA for LINC01587 Gene
- (1) REFSEQ mRNAs :
- (11) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LINC01587
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-
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available C4orf6 gene related products
- orf clones - Search results for available C4orf6 gene related products
- Applied Biological Materials Clones for LINC01587
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for LINC01587 Gene
NURSA nuclear receptor signaling pathways regulating expression of LINC01587 Gene:
LINC01587mRNA Expression by UniProt/SwissProt for LINC01587 Gene:
Q99440-CD006_HUMAN
Tissue specificity:
Expressed in neuroblastoma.
Primer Products
-
OriGene qPCR primer pairs for LINC01587
- genomics-online: primer clones - Search results for available C4orf6 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LINC01587 Gene
Orthologs for LINC01587 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C4H4orf6 33 |
|
- Species where no ortholog for LINC01587 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for LINC01587 Gene
No data available for Paralogs for LINC01587 Gene
Variants for LINC01587 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000200636 | -- | 5,524,658(+) | C/T | genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000330185 | -- | 5,524,660(+) | T/C | genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1001092913 | -- | 5,526,444(+) | G/A | intron_variant | |
| rs1001252295 | -- | 5,523,850(+) | C/G | upstream_transcript_variant | |
| rs1001598994 | -- | 5,523,750(+) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.66;
82.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for LINC01587 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LINC01587
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LINC01587 Gene
Disorders for LINC01587 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuroblastoma |
|
|
Search LINC01587 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for LINC01587
No data available for UniProtKB/Swiss-Prot and Genatlas for LINC01587 Gene
Publications for LINC01587 Gene
- Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. (PMID: 9016955) Kito K … Sakaki Y (Gene 1997) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Long interspersed nuclear element-1 (LINE1)-mediated deletion of EVC, EVC2, C4orf6, and STK32B in Ellis-van Creveld syndrome with borderline intelligence. (PMID: 18454448) Temtamy SA … Ruiz-Perez VL (Human mutation 2008) 3 58
- Adenylyl cyclase isoform-selective regulation of vascular smooth muscle proliferation and cytoskeletal reorganization. (PMID: 16973907) Gros R … Feldman RD (Circulation research 2006) 22 58
Products for LINC01587 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 3 available C4orf6 Antibodies ranked by validation data
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Sources for LINC01587 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (7) GeneLoc
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- (10) PhosphoSitePlus
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- (33) HomoloGene
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- (36) SGD
- (37) FlyBase
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- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (53) IMGT
- (54) Leiden
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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- (76) DISEASES
- (77) SIMAP
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- (79) LifeMap
- (80) miRTarBase
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- (100) SwitchGear Genomics
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- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (155) genomics-online
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