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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIN7C Gene

protein-coding   GIFtS: 55
GCID: GC11M027472

Lin-7 Homolog C (C. Elegans)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lin-7 Homolog C (C. Elegans)1 2     LIN-7-C2
MALS32 3 5     LIN-7C2
VELI32 3 5     Protein Lin-7 Homolog C2
LIN-7 Protein 31 2     veli-32
Mammalian Lin-Seven Protein 32 3     Lin-7C3
Vertebrate Lin-7 Homolog 32 3     Veli-33
MALS-32 3     

External Ids:    HGNC: 177891   Entrez Gene: 553272   Ensembl: ENSG000001489437   OMIM: 6123325   UniProtKB: Q9NUP93   

Export aliases for LIN7C gene to outside databases

Previous GC identifers: GC11M028868 GC11M028291 GC11M027555 GC11M027480 GC11M027214


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LIN7C Gene: 
LIN7C (lin-7 homolog C (C. elegans)) is a protein-coding gene. Diseases associated with LIN7C include wagr syndrome, and attention deficit hyperactivity disorder. GO annotations related to this gene include cytoskeletal protein binding and protein domain specific binding. An important paralog of this gene is PDZD11.

UniProtKB/Swiss-Prot: LIN7C_HUMAN, Q9NUP9
Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at
the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate
delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7
(LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell
adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal
postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by
beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2,
ERBB3 and ERBB4 to the basolateral membrane of epithelial cells

Gene Wiki entry for LIN7C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIN7C gene promoter:
         TBP   C/EBPbeta   CUTL1   C/EBPalpha   PPAR-alpha   MEF-2A   COMP1   TFIID   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIN7C promoter sequence
   Search SABiosciences Chromatin IP Primers for LIN7C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIN7C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14

LIN7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIN7C gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M027472:  view genomic region     (about GC identifiers)

Start:
27,515,965 bp from pter      End:
27,528,326 bp from pter
Size:
12,362 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIN7C_HUMAN, Q9NUP9 (See protein sequence)
Recommended Name: Protein lin-7 homolog C  
Size: 197 amino acids; 21834 Da
Subunit: Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact
with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and
DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels
KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of
LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin
cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17
via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A
or LIN7C). Interacts with MAPK12 (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane
protein. Cell junction (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density;
Peripheral membrane protein (By similarity). Cell junction, tight junction (By similarity). Cell junction,
synapse, synaptosome (By similarity). Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By
similarity). Mainly basolateral in renal epithelial cells
1 PDB 3D structure from and Proteopedia for LIN7C:
3LRA (3D)    

Explore the universe of human proteins at neXtProt for LIN7C: NX_Q9NUP9

Explore proteomics data for LIN7C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NUP9

  • LIN7C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIN7C Protein Expression
    REFSEQ proteins: NP_060832.1  
    ENSEMBL proteins: 
     ENSP00000278193   ENSP00000435353  

    Human Recombinant Protein Products for LIN7C: 
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    OriGene MassSpec for LIN7C 
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    GenScript Custom Purified and Recombinant Proteins Services for LIN7C
    Novus Biologicals LIN7C Proteins
    Novus Biologicals LIN7C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LIN7C
    Cloud-Clone Corp. Proteins for LIN7C 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005911cell-cell junction ----
    GO:0005923tight junction IEA--
    GO:0014069postsynaptic density IEA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0043005neuron projection IEA--

    LIN7C for ontologies           About GeneDecksing



    LIN7C Antibody Products: 
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    Abcam antibodies for LIN7C
    Cloud-Clone Corp. Antibodies for LIN7C 
    Search ThermoFisher Antibodies for LIN7C
    LSBio Antibodies in human, mouse, rat for LIN7C 

    Assay Products for LIN7C: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LIN7C
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    Cloud-Clone Corp. ELISAs for LIN7C 
    Cloud-Clone Corp. CLIAs for LIN7C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001478 PDZ
     IPR014775 L27_C
     IPR017365 Lin-7_homologue
     IPR004172 L27

    Graphical View of Domain Structure for InterPro Entry Q9NUP9

    ProtoNet protein and cluster: Q9NUP9

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: LIN7C_HUMAN, Q9NUP9
    Domain: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By
    similarity)
    Domain: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity)
    Domain: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and
    the association of LIN7 to membranes (By similarity)
    Similarity: Belongs to the lin-7 family
    Similarity: Contains 1 L27 domain
    Similarity: Contains 1 PDZ (DHR) domain


    LIN7C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIN7C_HUMAN, Q9NUP9
    Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at
    the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate
    delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7
    (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell
    adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal
    postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by
    beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2,
    ERBB3 and ERBB4 to the basolateral membrane of epithelial cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008092cytoskeletal protein binding IPI17987659
    GO:0019904protein domain specific binding IPI17237226
    GO:0030165PDZ domain binding IEA--
         
    LIN7C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LIN7C:
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lin7c):
     cellular  growth/size  homeostasis/metabolism  mortality/aging  nervous system 
     normal  renal/urinary system  respiratory system 

    LIN7C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lin7ctm1Dsb for LIN7C

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIN7C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIN7C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIN7C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIN7C 

    miRNA
    Products:
        
    miRTarBase miRNAs that target LIN7C:
    hsa-mir-1 (MIRT002793)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIN7C
    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate LIN7C (see all 116):
    hsa-miR-124* hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-128 hsa-miR-30d hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidLIN7C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIN7C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIN7C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIN7C
    Sirion Biotech Customized adenovirus for overexpression of LIN7C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LIN7C (see all 7)
    OriGene ORF clones in mouse, rat for LIN7C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIN7C (NM_018362)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIN7C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIN7C
    Sirion Biotech Customized lentivirus for stable overexpression of LIN7C 
                         Customized lentivirus expression plasmids for stable overexpression of LIN7C 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LIN7C
    Search LifeMap BioReagents cell lines for LIN7C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIN7C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIN7C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/47 Interacting proteins for LIN7C (Q9NUP93 ENSP000002781934) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206383P349313I2D: score=1 
    ENSG00000234258P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    AMY1AP047453I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0007269neurotransmitter secretion IEA--
    GO:0015031protein transport IEA--

    LIN7C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIN7C

    1 HMDB Compound for LIN7C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about LIN7C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIN7C gene: 
    NM_018362.3  

    Unigene Cluster for LIN7C:

    Lin-7 homolog C (C. elegans)
    Hs.91393  [show with all ESTs]
    Unigene Representative Sequence: NM_018362
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278193(uc001mrl.3 uc009yii.3) ENST00000524596
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIN7C
    8/116 QIAGEN miScript miRNA Assays for microRNAs that regulate LIN7C (see all 116):
    hsa-miR-124* hsa-miR-3607-3p hsa-miR-300 hsa-miR-4272 hsa-miR-128 hsa-miR-30d hsa-miR-374a hsa-miR-3138
    SwitchGear 3'UTR luciferase reporter plasmidLIN7C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIN7C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIN7C
    Clone
    Products:
         
    OriGene clones in human, mouse for LIN7C (see all 7)
    OriGene ORF clones in mouse, rat for LIN7C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LIN7C (NM_018362)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIN7C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIN7C
    Sirion Biotech Customized lentivirus for stable overexpression of LIN7C 
                         Customized lentivirus expression plasmids for stable overexpression of LIN7C 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LIN7C
    OriGene qSTAR qPCR primer pairs in human, mouse for LIN7C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIN7C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIN7C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIN7C

    Additional mRNA sequence: 

    AF090900.1 AK002077.1 AK025540.1 AK223156.1 AL161951.1 AL833601.1 BC009774.1 BC039459.1 
    BC053907.1 

    6 DOTS entries:

    DT.40197775  DT.91649633  DT.95168529  DT.120687074  DT.100794658  DT.86998154 

    24/162 AceView cDNA sequences (see all 162):

    CF138349 AI808505 BG623712 BX283615 BU507266 BM703880 CR600278 AU138171 
    BU902047 AK002077 BQ285888 AA643940 AU130405 CF135977 AA322992 BE894972 
    AI752962 AK025540 AI077833 AL047128 AW071509 BC009774 AA454069 AV656462 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LIN7C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                    -                     


    ECgene alternative splicing isoforms for LIN7C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIN7C expression in normal human tissues (normalized intensities)      LIN7C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGAATA
    LIN7C Expression
    About this image


    LIN7C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Blood (Hematopoietic System)
             bone marrow cd34+   

    See LIN7C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIN7C

    SOURCE GeneReport for Unigene cluster: Hs.91393
        SABiosciences Custom PCR Arrays for LIN7C
    Primer
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    OriGene qPCR primer pairs and template standards for LIN7C
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIN7C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIN7C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIN7C gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lin7c1 , 5 lin-7 homolog C (C. elegans)1, 5 90.69(n)1
    100(a)1
      2 (56.65 cM)5
    223431  NM_011699.31  NP_035829.11 
     1098908535 
    chicken
    (Gallus gallus)
    Aves LIN7C1 lin-7 homolog C (C. elegans) 85.37(n)
    100(a)
      421608  NM_001031067.1  NP_001026238.1 
    lizard
    (Anolis carolinensis)
    Reptilia LIN7C6
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343314.1(170059-174305)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041249.12   -- 79.26(n)    BC041249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lin7c1 lin-7 homolog C (C. elegans) 77.21(n)
    95.92(a)
      447934  NM_001004672.2  NP_001004672.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta veli1 CG7662-PA 67.01(n)
    80(a)
      43003  NM_143073.3  NP_651330.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-71 Protein LIN-7 63.8(n)
    70.43(a)
      175089  NM_001129192.1  NP_001122664.1 


    ENSEMBL Gene Tree for LIN7C (if available)
    TreeFam Gene Tree for LIN7C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIN7C gene
    PDZD112  LIN7B2  LIN7A2  
    11 SIMAP similar genes for LIN7C using alignment to 2 protein entries:     LIN7C_HUMAN (see all proteins):
    LIN7A    LIN7B    GOPC    DLG2    DLG1    MPDZ
    MAGI1    SYNJ2BP    DLG4    DLG3    PDZD11

    LIN7C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/216 SNPs in LIN7C are shown (see all 216)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415321461,2
    --27515488(+) CCAATA/GATTTT 1 -- int10--------
    rs107183811,2
    C--27515528(+) TCCAAT/-TTAAA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1913723461,2
    C--27515530(+) CAATTA/TAAAAA 1 -- int10--------
    rs1508853481,2
    C--27515553(+) TTGATC/TAAAAT 1 -- int10--------
    rs782295191,2
    C--27515584(+) TGAATC/TTTATT 1 -- int10--------
    rs1488835751,2
    C--27515595(+) CTTCT-/AAAGTTT 1 -- int10--------
    rs1921519341,2
    --27515595(+) CTTCTA/GAAGTT 1 -- int10--------
    rs745570601,2
    C,F--27515666(+) TGACCA/GGAATT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1382043771,2
    --27515727(+) AACACA/GAACAG 1 -- int10--------
    rs1852170531,2
    --27515747(+) TGCCAA/GGCACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for LIN7C (27515965 - 27528326 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LIN7C: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LIN7C
    DNA2.0 Custom Variant and Variant Library Synthesis for LIN7C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612332    OMIM disorders: --

    6 diseases for LIN7C:    About MalaCards
    wagr syndrome    attention deficit hyperactivity disorder    mood disorder    obesity
    squamous cell carcinoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for LIN7C:
    WAGR syndrome

    LIN7C for disorders           About GeneDecksing

    Genetic Association Database (GAD): LIN7C
    Human Genome Epidemiology (HuGE) Navigator: LIN7C (3 documents)

    Export disorders for LIN7C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIN7C gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with LIN7C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Implication of genetic variants near NEGR1, SEC16B, T MEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, a nd KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (2010)
    2. Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder. (PubMed id 18286632)1, 4 Lanktree M....Muglia P. (2008)
    3. Association Study of Theta EEG Asymmetry and Brain-derived Neurotrophic Factor Gene Variants in Childhood-onset Mood Disorder. (PubMed id 18543122)1, 4 Bulgin N.L....Kennedy J.L. (2008)
    4. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PubMed id 17237226)1, 2 Bohl J.... Vande Pol S.B. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. (PubMed id 10341223)1, 3 Jo K.... Bredt D.S. (1999)
    7. Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma. (PubMed id 17942893)1, 9 Onda T....Tanzawa H. (2007)
    8. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. (PubMed id 12006486)1, 9 Becamel C....Marin P. (2002)
    9. Genome-wide meta-analysis identifies 56 bone mineral d ensity loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55327 HGNC: 17789 AceView: LIN7C Ensembl:ENSG00000148943 euGenes: HUgn55327
    ECgene: LIN7C H-InvDB: LIN7C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIN7C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIN7C gene:
    Search GeneIP for patents involving LIN7C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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