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Aliases for LIN7C Gene

Aliases for LIN7C Gene

  • Lin-7 Homolog C (C. Elegans) 2 3
  • MALS3 3 4 6
  • VELI3 3 4 6
  • Mammalian Lin-Seven Protein 3 3 4
  • Vertebrate Lin-7 Homolog 3 3 4
  • LIN-7 Protein 3 2 3
  • LIN-7C 3 4
  • Veli-3 3 4
  • MALS-3 3 4
  • Protein Lin-7 Homolog C 3
  • LIN-7-C 3

External Ids for LIN7C Gene

Previous GeneCards Identifiers for LIN7C Gene

  • GC11M028868
  • GC11M028291
  • GC11M027555
  • GC11M027480
  • GC11M027214

Summaries for LIN7C Gene

GeneCards Summary for LIN7C Gene

LIN7C (Lin-7 Homolog C (C. Elegans)) is a Protein Coding gene. Diseases associated with LIN7C include wagr syndrome and mood disorder. GO annotations related to this gene include protein domain specific binding and cytoskeletal protein binding. An important paralog of this gene is LIN7A.

UniProtKB/Swiss-Prot for LIN7C Gene

  • Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells

Gene Wiki entry for LIN7C Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN7C Gene

Genomics for LIN7C Gene

Regulatory Elements for LIN7C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LIN7C Gene

Start:
27,494,418 bp from pter
End:
27,506,779 bp from pter
Size:
12,362 bases
Orientation:
Minus strand

Genomic View for LIN7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIN7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN7C Gene

Proteins for LIN7C Gene

  • Protein details for LIN7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUP9-LIN7C_HUMAN
    Recommended name:
    Protein lin-7 homolog C
    Protein Accession:
    Q9NUP9
    Secondary Accessions:

    Protein attributes for LIN7C Gene

    Size:
    197 amino acids
    Molecular mass:
    21834 Da
    Quaternary structure:
    • Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with MAPK12 (By similarity).

    Three dimensional structures from OCA and Proteopedia for LIN7C Gene

neXtProt entry for LIN7C Gene

Proteomics data for LIN7C Gene at MOPED

Post-translational modifications for LIN7C Gene

  • Ubiquitination at Lys23, Lys34, Lys76, and Lys176
  • Modification sites at PhosphoSitePlus

Other Protein References for LIN7C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIN7C Gene

Domains for LIN7C Gene

Protein Domains for LIN7C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN7C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUP9

UniProtKB/Swiss-Prot:

LIN7C_HUMAN :
  • Q9NUP9
Domain:
  • The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
  • The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
  • The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • Contains 1 L27 domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the lin-7 family.
genes like me logo Genes that share domains with LIN7C: view

No data available for Gene Families for LIN7C Gene

Function for LIN7C Gene

Molecular function for LIN7C Gene

UniProtKB/Swiss-Prot Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells

Gene Ontology (GO) - Molecular Function for LIN7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008092 cytoskeletal protein binding IPI 17987659
GO:0019904 protein domain specific binding IPI 17237226
GO:0030165 PDZ domain binding IEA --
GO:0097016 L27 domain binding IDA 20702775
genes like me logo Genes that share ontologies with LIN7C: view
genes like me logo Genes that share phenotypes with LIN7C: view

Animal Models for LIN7C Gene

MGI Knock Outs for LIN7C:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIN7C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LIN7C Gene

Localization for LIN7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIN7C Gene

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein. Cell junction, tight junction. Cell junction, synapse, synaptosome. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIN7C Gene COMPARTMENTS Subcellular localization image for LIN7C gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for LIN7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23201090
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 23201090
GO:0005923 bicellular tight junction IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with LIN7C: view

Pathways for LIN7C Gene

SuperPathways for LIN7C Gene

No Data Available

Gene Ontology (GO) - Biological Process for LIN7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002011 morphogenesis of an epithelial sheet IMP 23201090
GO:0006887 exocytosis IBA --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0008105 asymmetric protein localization IBA --
genes like me logo Genes that share ontologies with LIN7C: view

No data available for Pathways by source for LIN7C Gene

Compounds for LIN7C Gene

(1) HMDB Compounds for LIN7C Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with LIN7C: view

Transcripts for LIN7C Gene

mRNA/cDNA for LIN7C Gene

Unigene Clusters for LIN7C Gene

Lin-7 homolog C (C. elegans):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIN7C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIN7C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for LIN7C Gene

GeneLoc Exon Structure for
LIN7C
ECgene alternative splicing isoforms for
LIN7C

Expression for LIN7C Gene

mRNA expression in normal human tissues for LIN7C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIN7C Gene

SOURCE GeneReport for Unigene cluster for LIN7C Gene Hs.91393

genes like me logo Genes that share expressions with LIN7C: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LIN7C Gene

Orthologs for LIN7C Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN7C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIN7C 35
  • 99.83 (n)
  • 100 (a)
LIN7C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIN7C 35
  • 93.06 (n)
  • 100 (a)
LIN7C 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIN7C 35
  • 93.57 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Lin7c 35
  • 90.69 (n)
  • 100 (a)
Lin7c 16
Lin7c 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LIN7C 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIN7C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lin7c 35
  • 90.02 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves LIN7B 35
  • 85.28 (n)
  • 99.49 (a)
LIN7C 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIN7C 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin7c 35
  • 77.33 (n)
  • 94.92 (a)
zebrafish
(Danio rerio)
Actinopterygii lin7c 35
  • 77.16 (n)
  • 95.43 (a)
lin7c 36
  • 94 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta veli 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-7 36
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10352 36
  • 79 (a)
OneToMany
Species with no ortholog for LIN7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIN7C Gene

ENSEMBL:
Gene Tree for LIN7C (if available)
TreeFam:
Gene Tree for LIN7C (if available)

Paralogs for LIN7C Gene

Paralogs for LIN7C Gene

Selected SIMAP similar genes for LIN7C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIN7C: view

Variants for LIN7C Gene

Sequence variations from dbSNP and Humsavar for LIN7C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1131924 -- 27,495,242(-) GATTC(A/G)CCCGC utr-variant-3-prime
rs1140711 -- 27,495,862(-) GCATT(A/G)GGATT utr-variant-3-prime
rs3209593 -- 27,495,170(-) TTTTA(A/G)AAAAT utr-variant-3-prime
rs3215008 -- 27,502,061(+) CACAT(-/G/GT)TTGGT intron-variant
rs3763966 -- 27,494,758(+) AAGTT(C/T)TTGAA utr-variant-3-prime

Relevant External Links for LIN7C Gene

HapMap Linkage Disequilibrium report
LIN7C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LIN7C Gene

Disorders for LIN7C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for LIN7C Gene including...

Search for LIN7C Gene in MalaCards »

(1) University of Copenhagen DISEASES for LIN7C Gene

Relevant External Links for LIN7C

Genetic Association Database (GAD)
LIN7C
Human Genome Epidemiology (HuGE) Navigator
LIN7C
genes like me logo Genes that share disorders with LIN7C: view

No data available for UniProtKB/Swiss-Prot for LIN7C Gene

Publications for LIN7C Gene

  1. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. (PMID: 12006486) BAccamel C. … Marin P. (EMBO J. 2002) 3 23
  2. Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma. (PMID: 17942893) Onda T. … Tanzawa H. (Cancer Res. 2007) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. (PMID: 10341223) Jo K. … Bredt D.S. (J. Neurosci. 1999) 2 3
  5. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PMID: 17237226) Bohl J. … Vande Pol S.B. (J. Biol. Chem. 2007) 3 4

Products for LIN7C Gene

Sources for LIN7C Gene

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