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Aliases for LIN7B Gene

Aliases for LIN7B Gene

  • Lin-7 Homolog B (C. Elegans) 2 3
  • Mammalian Lin-Seven Protein 2 3 4
  • Vertebrate Lin-7 Homolog 2 3 4
  • LIN-7B 3 4
  • Veli-2 3 4
  • MALS-2 3 4
  • HLin7B 3 4
  • HVeli2 3 4
  • MALS2 3 4
  • VELI2 3 4

External Ids for LIN7B Gene

Previous GeneCards Identifiers for LIN7B Gene

  • GC19P050275
  • GC19P049985
  • GC19P054293
  • GC19P054309
  • GC19P054275
  • GC19P049618
  • GC19P045993
  • GC19P049623
  • GC19P049627

Summaries for LIN7B Gene

GeneCards Summary for LIN7B Gene

LIN7B (Lin-7 Homolog B (C. Elegans)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include protein domain specific binding and L27 domain binding. An important paralog of this gene is LIN7A.

UniProtKB/Swiss-Prot for LIN7B Gene

  • Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Gene Wiki entry for LIN7B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN7B Gene

Genomics for LIN7B Gene

Regulatory Elements for LIN7B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LIN7B Gene

Chromosome:
19
Start:
49,114,324 bp from pter
End:
49,118,460 bp from pter
Size:
4,137 bases
Orientation:
Plus strand

Genomic View for LIN7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIN7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN7B Gene

Proteins for LIN7B Gene

  • Protein details for LIN7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAP6-LIN7B_HUMAN
    Recommended name:
    Protein lin-7 homolog B
    Protein Accession:
    Q9HAP6

    Protein attributes for LIN7B Gene

    Size:
    207 amino acids
    Molecular mass:
    22896 Da
    Quaternary structure:
    • Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1. Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1 (By similarity). Interacts with ASIC3. Interacts with TOPK. Interacts with RTKN.

    Three dimensional structures from OCA and Proteopedia for LIN7B Gene

    Alternative splice isoforms for LIN7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIN7B Gene

Proteomics data for LIN7B Gene at MOPED

Post-translational modifications for LIN7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIN7B Gene

Antibody Products

No data available for DME Specific Peptides for LIN7B Gene

Domains & Families for LIN7B Gene

Protein Domains for LIN7B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAP6

UniProtKB/Swiss-Prot:

LIN7B_HUMAN :
  • The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
  • Belongs to the lin-7 family.
Domain:
  • The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
  • The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
  • The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • Contains 1 L27 domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the lin-7 family.
genes like me logo Genes that share domains with LIN7B: view

No data available for Gene Families for LIN7B Gene

Function for LIN7B Gene

Molecular function for LIN7B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Gene Ontology (GO) - Molecular Function for LIN7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019904 protein domain specific binding IPI 17237226
GO:0030165 PDZ domain binding IEA --
GO:0097016 L27 domain binding IBA --
genes like me logo Genes that share ontologies with LIN7B: view
genes like me logo Genes that share phenotypes with LIN7B: view

Animal Models for LIN7B Gene

MGI Knock Outs for LIN7B:

Animal Model Products

miRNA for LIN7B Gene

miRTarBase miRNAs that target LIN7B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LIN7B Gene

Localization for LIN7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIN7B Gene

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein. Cell junction, tight junction. Cell junction, synapse, synaptosome. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIN7B Gene COMPARTMENTS Subcellular localization image for LIN7B gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for LIN7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IBA --
GO:0005923 bicellular tight junction IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with LIN7B: view

Pathways & Interactions for LIN7B Gene

genes like me logo Genes that share pathways with LIN7B: view

Gene Ontology (GO) - Biological Process for LIN7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IBA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0008105 asymmetric protein localization IBA --
genes like me logo Genes that share ontologies with LIN7B: view

No data available for SIGNOR curated interactions for LIN7B Gene

Drugs & Compounds for LIN7B Gene

(1) Drugs for LIN7B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with LIN7B: view

Transcripts for LIN7B Gene

mRNA/cDNA for LIN7B Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LIN7B Gene

Lin-7 homolog B (C. elegans):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIN7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIN7B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7
SP1: - - - - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for LIN7B Gene

GeneLoc Exon Structure for
LIN7B
ECgene alternative splicing isoforms for
LIN7B

Expression for LIN7B Gene

mRNA expression in normal human tissues for LIN7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIN7B Gene

This gene is overexpressed in Brain (36.1), Fetal ovary (18.2), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIN7B Gene



SOURCE GeneReport for Unigene cluster for LIN7B Gene Hs.221737

genes like me logo Genes that share expression patterns with LIN7B: view

Protein tissue co-expression partners for LIN7B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LIN7B Gene

Orthologs for LIN7B Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIN7B 35
  • 91.71 (n)
  • 99.5 (a)
LIN7B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIN7B 35
  • 92.11 (n)
  • 100 (a)
LIN7B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lin7b 35
  • 87.44 (n)
  • 98.07 (a)
Lin7b 16
Lin7b 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lin7b 35
  • 87.6 (n)
  • 98.55 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LIN7B 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIN7B 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin7b 35
  • 76.33 (n)
  • 93.24 (a)
zebrafish
(Danio rerio)
Actinopterygii lin7b 35
  • 74.72 (n)
  • 89.37 (a)
lin7b 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.824 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005858 35
  • 70.39 (n)
  • 78.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta veli 35
  • 67.18 (n)
  • 77.44 (a)
veli 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-7 35
  • 60.71 (n)
  • 66.84 (a)
lin-7 36
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10352 36
  • 75 (a)
OneToMany
Species with no ortholog for LIN7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIN7B Gene

ENSEMBL:
Gene Tree for LIN7B (if available)
TreeFam:
Gene Tree for LIN7B (if available)

Paralogs for LIN7B Gene

Paralogs for LIN7B Gene

(9) SIMAP similar genes for LIN7B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LIN7B: view

Variants for LIN7B Gene

Sequence variations from dbSNP and Humsavar for LIN7B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs764764032 -- 49,116,427(+) CGCCA(C/T)GGAGG synonymous-codon, reference, intron-variant, nc-transcript-variant
rs764318960 -- 49,113,156(+) GCACT(A/C)GAGAC upstream-variant-2KB
rs764281096 -- 49,116,204(+) CCCAC(C/T)CCAGC intron-variant
rs764139003 -- 49,115,365(+) GTCTA(A/T)TTAAC intron-variant
rs764086645 -- 49,114,851(+) CAGAC(A/G)TGTCC missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LIN7B Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912252 CNV Loss 21882294
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912258 CNV Loss 21882294
dgv3971n71 CNV Loss 21882294
esv1011024 CNV Deletion 20482838

Variation tolerance for LIN7B Gene

Residual Variation Intolerance Score: 42.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIN7B Gene

HapMap Linkage Disequilibrium report
LIN7B
Human Gene Mutation Database (HGMD)
LIN7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN7B Gene

Disorders for LIN7B Gene

Relevant External Links for LIN7B

Genetic Association Database (GAD)
LIN7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIN7B
genes like me logo Genes that share disorders with LIN7B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN7B Gene

Publications for LIN7B Gene

  1. Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons. (PMID: 16979770) Sudo K. … Nagata K. (Neurosci. Res. 2006) 23 67
  2. Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins. (PMID: 15030393) Iwamoto T. … Inui M. (J. Neurochem. 2004) 23 67
  3. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. (PMID: 10341223) Jo K. … Bredt D.S. (J. Neurosci. 1999) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. (PMID: 25196215) Mizuno M. … Nagata K. (J. Neurochem. 2015) 67

Products for LIN7B Gene

Sources for LIN7B Gene

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