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Aliases for LIN7A Gene

Aliases for LIN7A Gene

  • Lin-7 Homolog A, Crumbs Cell Polarity Complex Component 2 3
  • Mammalian Lin-Seven Protein 1 3 4
  • Lin-7 Homolog A (C. Elegans) 2 5
  • Tax Interaction Protein 33 3 4
  • Vertebrate Lin-7 Homolog 1 3 4
  • Mammalian LIN-7 1 2 3
  • LIN-7A 3 4
  • Veli-1 3 4
  • MALS-1 3 4
  • TIP-33 3 4
  • HLin-7 3 4
  • VELI1 3 4
  • Vertebrate LIN7 Homolog 1 3
  • Lin-7 Homolog A 3
  • MALS1 4
  • LIN7 3

External Ids for LIN7A Gene

Previous GeneCards Identifiers for LIN7A Gene

  • GC12M081166
  • GC12M081555
  • GC12M079693
  • GC12M078248

Summaries for LIN7A Gene

GeneCards Summary for LIN7A Gene

LIN7A (Lin-7 Homolog A, Crumbs Cell Polarity Complex Component) is a Protein Coding gene. Diseases associated with LIN7A include Pulmonary Aspergilloma. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. GO annotations related to this gene include PDZ domain binding and L27 domain binding. An important paralog of this gene is LIN7C.

UniProtKB/Swiss-Prot for LIN7A Gene

  • Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Gene Wiki entry for LIN7A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN7A Gene

Genomics for LIN7A Gene

Regulatory Elements for LIN7A Gene

Enhancers for LIN7A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIN7A on UCSC Golden Path with GeneCards custom track

Promoters for LIN7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIN7A on UCSC Golden Path with GeneCards custom track

Genomic Location for LIN7A Gene

Chromosome:
12
Start:
80,792,520 bp from pter
End:
80,937,925 bp from pter
Size:
145,406 bases
Orientation:
Minus strand

Genomic View for LIN7A Gene

Genes around LIN7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN7A Gene

Proteins for LIN7A Gene

  • Protein details for LIN7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14910-LIN7A_HUMAN
    Recommended name:
    Protein lin-7 homolog A
    Protein Accession:
    O14910
    Secondary Accessions:
    • A4FTY3
    • Q147W1
    • Q6LES3
    • Q7LDS4

    Protein attributes for LIN7A Gene

    Size:
    233 amino acids
    Molecular mass:
    25997 Da
    Quaternary structure:
    • Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCH11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).

neXtProt entry for LIN7A Gene

Proteomics data for LIN7A Gene at MOPED

Post-translational modifications for LIN7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIN7A Gene

No data available for DME Specific Peptides for LIN7A Gene

Domains & Families for LIN7A Gene

Gene Families for LIN7A Gene

Protein Domains for LIN7A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14910

UniProtKB/Swiss-Prot:

LIN7A_HUMAN :
  • The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
  • Belongs to the lin-7 family.
Domain:
  • The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
  • The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
  • The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • Contains 1 L27 domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the lin-7 family.
genes like me logo Genes that share domains with LIN7A: view

Function for LIN7A Gene

Molecular function for LIN7A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

Gene Ontology (GO) - Molecular Function for LIN7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097016 L27 domain binding IPI 17237226
genes like me logo Genes that share ontologies with LIN7A: view
genes like me logo Genes that share phenotypes with LIN7A: view

Animal Models for LIN7A Gene

MGI Knock Outs for LIN7A:

Animal Model Products

miRNA for LIN7A Gene

miRTarBase miRNAs that target LIN7A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIN7A Gene

Localization for LIN7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIN7A Gene

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Peripheral membrane protein. Cell junction, tight junction. Cell junction, synapse, synaptosome. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIN7A Gene COMPARTMENTS Subcellular localization image for LIN7A gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
nucleus 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LIN7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IBA --
GO:0005923 bicellular tight junction IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0045202 synapse IBA --
genes like me logo Genes that share ontologies with LIN7A: view

Pathways & Interactions for LIN7A Gene

genes like me logo Genes that share pathways with LIN7A: view

Gene Ontology (GO) - Biological Process for LIN7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion IEA,TAS --
GO:1903361 protein localization to basolateral plasma membrane IBA --
genes like me logo Genes that share ontologies with LIN7A: view

No data available for SIGNOR curated interactions for LIN7A Gene

Drugs & Compounds for LIN7A Gene

(1) Drugs for LIN7A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LIN7A: view

Transcripts for LIN7A Gene

Unigene Clusters for LIN7A Gene

Lin-7 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIN7A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for LIN7A Gene

GeneLoc Exon Structure for
LIN7A
ECgene alternative splicing isoforms for
LIN7A

Expression for LIN7A Gene

mRNA expression in normal human tissues for LIN7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIN7A Gene

This gene is overexpressed in Whole Blood (x5.4), Brain - Cerebellar Hemisphere (x4.8), and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for LIN7A Gene

This gene is overexpressed in Brain (21.1), Retina (17.5), and Frontal cortex (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIN7A Gene



SOURCE GeneReport for Unigene cluster for LIN7A Gene Hs.144333

mRNA Expression by UniProt/SwissProt for LIN7A Gene

O14910-LIN7A_HUMAN
Tissue specificity: Expressed in brain, testis, kidney, placenta and liver.
genes like me logo Genes that share expression patterns with LIN7A: view

Protein tissue co-expression partners for LIN7A Gene

Primer Products

Orthologs for LIN7A Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIN7A 35
  • 95.28 (n)
  • 100 (a)
LIN7A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIN7A 35
  • 94.66 (n)
  • 100 (a)
LIN7A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lin7a 35
  • 92.42 (n)
  • 99.57 (a)
Lin7a 16
Lin7a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIN7A 35
  • 98.57 (n)
  • 98.28 (a)
LIN7A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911013 35
  • 91.07 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia LIN7A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIN7A 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIN7A 35
  • 85.31 (n)
  • 98.51 (a)
LIN7A 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIN7A 36
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lin7a 35
  • 79.32 (n)
  • 96.41 (a)
zgc73090 35
lin7a 36
  • 94 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta veli 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-7 36
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10352 36
  • 72 (a)
OneToMany
Species with no ortholog for LIN7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LIN7A Gene

ENSEMBL:
Gene Tree for LIN7A (if available)
TreeFam:
Gene Tree for LIN7A (if available)

Paralogs for LIN7A Gene

Paralogs for LIN7A Gene

(7) SIMAP similar genes for LIN7A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LIN7A: view

Variants for LIN7A Gene

Sequence variations from dbSNP and Humsavar for LIN7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1920987 -- 80,898,106(-) ataaa(A/C)cctaa intron-variant
rs1920988 -- 80,894,344(-) GGAAA(A/G)TAATC intron-variant
rs1920989 -- 80,894,186(-) TGAAC(A/G)AGAAC intron-variant
rs1920993 -- 80,834,979(+) TAAAT(C/T)GAATC intron-variant
rs1920994 -- 80,863,732(+) TTTAA(G/T)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIN7A Gene

Variant ID Type Subtype PubMed ID
nsv789 CNV Loss 18451855
esv269763 CNV Insertion 20981092
esv273340 CNV Insertion 20981092

Variation tolerance for LIN7A Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIN7A Gene

Human Gene Mutation Database (HGMD)
LIN7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN7A Gene

Disorders for LIN7A Gene

MalaCards: The human disease database

(1) MalaCards diseases for LIN7A Gene - From: DISEASES

Disorder Aliases PubMed IDs
pulmonary aspergilloma
- elite association - COSMIC cancer census association via MalaCards
Search LIN7A in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIN7A

Genetic Association Database (GAD)
LIN7A
Human Genome Epidemiology (HuGE) Navigator
LIN7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIN7A
genes like me logo Genes that share disorders with LIN7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIN7A Gene

Publications for LIN7A Gene

  1. The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions. (PMID: 17237226) Bohl J. … Vande Pol S.B. (J. Biol. Chem. 2007) 2 3 4 67
  2. Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder. (PMID: 18286632) Lanktree M. … Muglia P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 23
  3. Coordinated folding and association of the LIN-2, -7 (L27) domain. An obligate heterodimerization involved in assembly of signaling and cell polarity complexes. (PMID: 12110687) Harris B.Z. … Lim W.A. (J. Biol. Chem. 2002) 3 23
  4. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. (PMID: 10341223) Jo K. … Bredt D.S. (J. Neurosci. 1999) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LIN7A Gene

Sources for LIN7A Gene

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