Aliases for LIN54 Gene
External Ids for LIN54 Gene
Previous GeneCards Identifiers for LIN54 Gene
LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
GeneCards Summary for LIN54 Gene
LIN54 (Lin-54 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. An important paralog of this gene is TESMIN.
UniProtKB/Swiss-Prot for LIN54 Gene
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.