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Aliases for LIN52 Gene

Aliases for LIN52 Gene

  • Lin-52 DREAM MuvB Core Complex Component 2 3 5
  • C14orf46 3 4
  • Chromosome 14 Open Reading Frame 46 2
  • Lin-52 Homolog (C. Elegans) 2
  • Protein Lin-52 Homolog 3
  • Lin-52 Homolog 3
  • C14_5549 3

External Ids for LIN52 Gene

Previous HGNC Symbols for LIN52 Gene

  • C14orf46

Previous GeneCards Identifiers for LIN52 Gene

  • GC14P073622
  • GC14P074551
  • GC14P054718

Summaries for LIN52 Gene

GeneCards Summary for LIN52 Gene

LIN52 (Lin-52 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cellular senescence (KEGG).

Additional gene information for LIN52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN52 Gene

Genomics for LIN52 Gene

Regulatory Elements for LIN52 Gene

Enhancers for LIN52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H074133 2.1 Ensembl ENCODE 18.9 +49.7 49723 1 HDAC1 PKNOX1 FOXA2 ZFP64 FEZF1 RAD21 YY1 ZNF766 KLF7 OVOL3 LIN52 LOC100506476 ALDH6A1 ENTPD5 GC14P074134 LOC105370563
GH14H074083 1.1 ENCODE 27.2 +0.1 116 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 LOC100506476 ZNF410 LIN52 MLH3 ELMSAN1 YLPM1 FCF1 PTGR2 ENSG00000258559 ABCD4
GH14H074140 1.6 FANTOM5 Ensembl ENCODE 18.6 +55.8 55776 0 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 KLF7 SP3 YY2 TSHZ1 MLH3 YLPM1 ENSG00000258559 ABCD4 LIN52 ENSG00000259138 ELMSAN1 NEK9 ENSG00000258443 ALDH6A1
GH14H074591 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +511.4 511434 9 TFAP4 KLF1 SAP130 ZFP64 ZNF697 RELA ZFHX2 GLIS2 POLR2A IKZF2 PNMA1 DNAL1 LIN52 AREL1 NPC2 LTBP2 LOC101928352 ENSG00000258425
GH14H074564 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +485.8 485755 11 PKNOX1 SIN3A FEZF1 GLI4 ZBTB7B ZNF416 FOS KLF7 SP3 YY2 ELMSAN1 ZNF410 YLPM1 FCF1 ENSG00000258559 MLH3 NEK9 PROX2 LTBP2 ENSG00000259005
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIN52 on UCSC Golden Path with GeneCards custom track

Promoters for LIN52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070700 -96 2201 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for LIN52 Gene

Chromosome:
14
Start:
74,084,796 bp from pter
End:
74,201,235 bp from pter
Size:
116,440 bases
Orientation:
Plus strand

Genomic View for LIN52 Gene

Genes around LIN52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN52 Gene

Proteins for LIN52 Gene

  • Protein details for LIN52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LA3-LIN52_HUMAN
    Recommended name:
    Protein lin-52 homolog
    Protein Accession:
    Q52LA3

    Protein attributes for LIN52 Gene

    Size:
    116 amino acids
    Molecular mass:
    13001 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Three dimensional structures from OCA and Proteopedia for LIN52 Gene

neXtProt entry for LIN52 Gene

Post-translational modifications for LIN52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIN52 Gene

No data available for DME Specific Peptides for LIN52 Gene

Domains & Families for LIN52 Gene

Gene Families for LIN52 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LIN52 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN52 Gene

Graphical View of Domain Structure for InterPro Entry

Q52LA3

UniProtKB/Swiss-Prot:

LIN52_HUMAN :
  • Belongs to the lin-52 family.
Family:
  • Belongs to the lin-52 family.
genes like me logo Genes that share domains with LIN52: view

Function for LIN52 Gene

Phenotypes From GWAS Catalog for LIN52 Gene

Gene Ontology (GO) - Molecular Function for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17531812
genes like me logo Genes that share ontologies with LIN52: view
genes like me logo Genes that share phenotypes with LIN52: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIN52
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN52 Gene

Localization for LIN52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN52 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070176 DRM complex IEA --
genes like me logo Genes that share ontologies with LIN52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN52 Gene

Pathways & Interactions for LIN52 Gene

genes like me logo Genes that share pathways with LIN52: view

Pathways by source for LIN52 Gene

1 KEGG pathway for LIN52 Gene

Gene Ontology (GO) - Biological Process for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN52: view

No data available for SIGNOR curated interactions for LIN52 Gene

Drugs & Compounds for LIN52 Gene

No Compound Related Data Available

Transcripts for LIN52 Gene

Unigene Clusters for LIN52 Gene

Lin-52 homolog (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIN52
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LIN52 Gene

No ASD Table

Relevant External Links for LIN52 Gene

GeneLoc Exon Structure for
LIN52
ECgene alternative splicing isoforms for
LIN52

Expression for LIN52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIN52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIN52 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIN52 Gene



Protein tissue co-expression partners for LIN52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIN52 Gene:

LIN52

SOURCE GeneReport for Unigene cluster for LIN52 Gene:

Hs.612866

Evidence on tissue expression from TISSUES for LIN52 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LIN52: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN52 Gene

Orthologs for LIN52 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIN52 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia LIN52 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIN52 33 34
  • 95.11 (n)
dog
(Canis familiaris)
Mammalia LIN52 33 34
  • 94.54 (n)
rat
(Rattus norvegicus)
Mammalia Lin52 33
  • 91.67 (n)
mouse
(Mus musculus)
Mammalia Lin52 33 16 34
  • 91.38 (n)
chicken
(Gallus gallus)
Aves LIN52 33 34
  • 78.57 (n)
lizard
(Anolis carolinensis)
Reptilia LIN52 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin52 33
  • 74.4 (n)
Str.15097 33
zebrafish
(Danio rerio)
Actinopterygii lin52 33 34
  • 75.89 (n)
Dr.16539 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10244 33
fruit fly
(Drosophila melanogaster)
Insecta lin-52 34
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1939 33
Species where no ortholog for LIN52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIN52 Gene

ENSEMBL:
Gene Tree for LIN52 (if available)
TreeFam:
Gene Tree for LIN52 (if available)

Paralogs for LIN52 Gene

(1) SIMAP similar genes for LIN52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIN52: view

No data available for Paralogs for LIN52 Gene

Variants for LIN52 Gene

Sequence variations from dbSNP and Humsavar for LIN52 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs886050733 Uncertain significance 74,084,453(-) CTGGC(A/C)GCTGT upstream-variant-2KB, utr-variant-5-prime
rs1000022920 -- 74,166,158(+) AGTGC(A/T)GGGAT intron-variant
rs1000027612 -- 74,115,310(+) ATATT(G/T)TCTTG intron-variant, utr-variant-3-prime
rs1000048583 -- 74,138,483(+) GTTTT(A/G)TTTGC intron-variant
rs1000104554 -- 74,129,333(+) AGGTT(G/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIN52 Gene

Variant ID Type Subtype PubMed ID
dgv1937n100 CNV gain 25217958
dgv1939n100 CNV gain 25217958
dgv1940n100 CNV gain 25217958
esv1167280 CNV insertion 17803354
esv21637 CNV gain 19812545
esv22046 CNV loss 19812545
esv2614022 CNV deletion 19546169
esv2616082 CNV insertion 19546169
esv2748869 CNV deletion 23290073
esv2759997 CNV gain 17122850
esv2760331 CNV gain 21179565
esv3634934 CNV gain 21293372
esv3634935 CNV loss 21293372
nsv1108911 CNV deletion 24896259
nsv520879 CNV loss 19592680
nsv9154 CNV gain 18304495

Variation tolerance for LIN52 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIN52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIN52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN52 Gene

Disorders for LIN52 Gene

Relevant External Links for LIN52

Genetic Association Database (GAD)
LIN52
Human Genome Epidemiology (HuGE) Navigator
LIN52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIN52

No disorders were found for LIN52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN52 Gene

Publications for LIN52 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L … DeCaprio JA (Genes & development 2011) 2 3 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N … Mountain J (PLoS genetics 2010) 3 45 60
  4. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PMID: 17671431) Schmit F … Gaubatz S (Cell cycle (Georgetown, Tex.) 2007) 3 4 60
  5. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4 60

Products for LIN52 Gene

Sources for LIN52 Gene

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