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Aliases for LIN52 Gene

Aliases for LIN52 Gene

  • Lin-52 DREAM MuvB Core Complex Component 2 3 5
  • C14orf46 3 4
  • Chromosome 14 Open Reading Frame 46 2
  • Lin-52 Homolog (C. Elegans) 2
  • Lin-52 Homolog 3
  • C14_5549 3

External Ids for LIN52 Gene

Previous HGNC Symbols for LIN52 Gene

  • C14orf46

Previous GeneCards Identifiers for LIN52 Gene

  • GC14P073622
  • GC14P074551
  • GC14P054718

Summaries for LIN52 Gene

GeneCards Summary for LIN52 Gene

LIN52 (Lin-52 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN52 Gene

Genomics for LIN52 Gene

Regulatory Elements for LIN52 Gene

Enhancers for LIN52 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIN52 on UCSC Golden Path with GeneCards custom track

Promoters for LIN52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIN52 on UCSC Golden Path with GeneCards custom track

Genomic Location for LIN52 Gene

Chromosome:
14
Start:
74,084,796 bp from pter
End:
74,201,235 bp from pter
Size:
116,440 bases
Orientation:
Plus strand

Genomic View for LIN52 Gene

Genes around LIN52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN52 Gene

Proteins for LIN52 Gene

  • Protein details for LIN52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52LA3-LIN52_HUMAN
    Recommended name:
    Protein lin-52 homolog
    Protein Accession:
    Q52LA3

    Protein attributes for LIN52 Gene

    Size:
    116 amino acids
    Molecular mass:
    13001 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.

    Three dimensional structures from OCA and Proteopedia for LIN52 Gene

neXtProt entry for LIN52 Gene

Proteomics data for LIN52 Gene at MOPED

Post-translational modifications for LIN52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIN52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIN52 Gene

Domains & Families for LIN52 Gene

Protein Domains for LIN52 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN52 Gene

Graphical View of Domain Structure for InterPro Entry

Q52LA3

UniProtKB/Swiss-Prot:

LIN52_HUMAN :
  • Belongs to the lin-52 family.
Family:
  • Belongs to the lin-52 family.
genes like me logo Genes that share domains with LIN52: view

No data available for Gene Families for LIN52 Gene

Function for LIN52 Gene

genes like me logo Genes that share phenotypes with LIN52: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN52 Gene

Localization for LIN52 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIN52 Gene COMPARTMENTS Subcellular localization image for LIN52 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with LIN52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN52 Gene

Pathways & Interactions for LIN52 Gene

genes like me logo Genes that share pathways with LIN52: view

Pathways by source for LIN52 Gene

Gene Ontology (GO) - Biological Process for LIN52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN52: view

No data available for SIGNOR curated interactions for LIN52 Gene

Drugs & Compounds for LIN52 Gene

No Compound Related Data Available

Transcripts for LIN52 Gene

Unigene Clusters for LIN52 Gene

Lin-52 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIN52 Gene

No ASD Table

Relevant External Links for LIN52 Gene

GeneLoc Exon Structure for
LIN52
ECgene alternative splicing isoforms for
LIN52

Expression for LIN52 Gene

mRNA expression in normal human tissues for LIN52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIN52 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIN52 Gene



SOURCE GeneReport for Unigene cluster for LIN52 Gene Hs.612866

genes like me logo Genes that share expression patterns with LIN52: view

Protein tissue co-expression partners for LIN52 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LIN52 Gene

Orthologs for LIN52 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN52 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIN52 35
  • 95.11 (n)
  • 100 (a)
LIN52 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIN52 35
  • 94.54 (n)
  • 100 (a)
LIN52 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lin52 35
  • 91.38 (n)
  • 100 (a)
Lin52 16
Lin52 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIN52 35
  • 100 (n)
  • 100 (a)
LIN52 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lin52 35
  • 91.67 (n)
  • 99.14 (a)
oppossum
(Monodelphis domestica)
Mammalia LIN52 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIN52 35
  • 78.57 (n)
  • 95.54 (a)
LIN52 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIN52 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin52 35
  • 74.4 (n)
  • 91.07 (a)
Str.15097 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16539 35
lin52 35
  • 75.89 (n)
  • 83.93 (a)
lin52 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10244 35
fruit fly
(Drosophila melanogaster)
Insecta lin-52 36
  • 24 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1939 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for LIN52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIN52 Gene

ENSEMBL:
Gene Tree for LIN52 (if available)
TreeFam:
Gene Tree for LIN52 (if available)

Paralogs for LIN52 Gene

(1) SIMAP similar genes for LIN52 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LIN52: view

No data available for Paralogs for LIN52 Gene

Variants for LIN52 Gene

Sequence variations from dbSNP and Humsavar for LIN52 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140458 -- 74,163,635(+) TTTTT(A/T)AAAAA intron-variant
rs7141652 -- 74,094,003(+) aGGTA(C/T)AAATC intron-variant
rs1548769 -- 74,179,896(-) tctga(A/G)aacca intron-variant
rs7493695 -- 74,166,132(+) gtgat(C/T)tgccc intron-variant
rs7142674 -- 74,176,540(+) gtgtg(A/C)tgaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIN52 Gene

Variant ID Type Subtype PubMed ID
dgv642e1 CNV Complex 17122850
esv22046 CNV Loss 19812545
esv2614022 CNV Deletion 19546169
dgv1960n71 CNV Loss 21882294
nsv9154 CNV Gain 18304495
esv21637 CNV Gain 19812545
esv2748869 CNV Deletion 23290073
nsv902096 CNV Gain 21882294
nsv902097 CNV Gain 21882294
nsv520879 CNV Loss 19592680
esv2616082 CNV Insertion 19546169
esv1167280 CNV Insertion 17803354

Variation tolerance for LIN52 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LIN52 Gene

Disorders for LIN52 Gene

Relevant External Links for LIN52

Genetic Association Database (GAD)
LIN52
Human Genome Epidemiology (HuGE) Navigator
LIN52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIN52

No disorders were found for LIN52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN52 Gene

Publications for LIN52 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L. … DeCaprio J.A. (Genes Dev. 2011) 2 3 67
  2. Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. (PMID: 17075059) Harrison M.M. … Horvitz H.R. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. (PMID: 21498571) TschAPp K. … Dyson N. (Genes Dev. 2011) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for LIN52 Gene

Sources for LIN52 Gene

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