LIN52 Gene
protein-coding GIFtS: 45
GCID: GC14P074551
|
|
lin-52 homolog (C. elegans)(Previous name: chromosome 14 open reading frame 46 )
(Previous symbol: C14orf46)
| |
Aliases
for LIN52 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lin-52 Homolog (C. Elegans)1 2 | | C14orf461 2 3 | | Chromosome 14 Open Reading Frame 461 | | C14_55491 | | Protein Lin-52 Homolog2 |
Export aliases for LIN52 gene to outside databasesPrevious GC identifers: GC14P073622 GC14P054718 |
Summaries
for LIN52 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LIN52 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LIN52 gene promoter:
AML1a Pbx1a POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Tal-1beta POU3F2 N-Myc c-Rel Zic1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for LIN52
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIN52 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.2LIN52 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P074551: view genomic region
(about GC identifiers)
Start:
|
74,551,499 bp from pter |
End:
|
74,667,936 bp from pter |
Size:
|
116,438 bases |
Orientation:
|
plus strand |
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Proteins
for LIN52 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LIN52_HUMAN, Q52LA3 (See
protein sequence)Recommended Name: Protein lin-52 homolog Size: 116 amino acids; 13001 Da
Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52,LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cellcycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds toMYBL2Explore the universe of human proteins at neXtProt for LIN52: NX_Q52LA3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q52LA3
LIN52 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001019845.1
ENSEMBL proteins: ENSP00000451812 ENSP00000452513 Reactome Protein details: Q52LA3
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
LIN52 for ontologies About GeneDecksing
LIN52 Antibody Products:
Assay Products for LIN52: |
Protein
Domains /
Families
for LIN52 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LIN52 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q52LA3ProtoNet protein and cluster: Q52LA3 UniProtKB/Swiss-Prot: LIN52_HUMAN, Q52LA3Similarity: Belongs to the lin-52 family |
Function
for LIN52 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LIN52 (NM_001024674) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIN52 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIN52 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIN52 |
|
Pathways & Interactions
for LIN52 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell Cycle | | | 2 | G1/S Transition | | | 3 | Cell cycle_Cell cycle (generic schema) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for LIN52
LIN52 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LIN52
5 Interacting proteins for LIN52 (Q52LA33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000278 | mitotic cell cycle |
TAS | -- |
LIN52 for ontologies About GeneDecksing
|
Drugs & Compounds
for LIN52 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LIN52
Search CenterWatch for drugs/clinical trials and news about LIN52
|
Transcripts
for LIN52 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LIN52 gene: NM_001024674.2 Unigene Cluster for LIN52: Lin-52 homolog (C. elegans) Hs.612866 [show with all ESTs]Unigene Representative Sequence: AK0554226 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000555028(uc001xpp.2) ENST00000554938 ENST00000553404(uc010asb.2)
ENST00000554076 ENST00000554289 ENST00000556524
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LIN52 (NM_001024674) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIN52 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIN52 |
Additional cDNA sequence: AK023979.1 AK055422.1 AK307062.1 BC009539.2 BC094003.1 BC094005.1 7 DOTS entries: DT.40305609 DT.120753961 DT.91752559 DT.120753962 DT.120753970 DT.95368995 DT.212437 24/47 AceView cDNA sequences (see all 47): CR597277 CR607696 BE407266 CR593198 BM806144 AA352275 BQ653946 AU142444 BX953472 BM466487 BX351402 AL600046 BG676720 BC009539 BQ898080 BX482815 AA312626 BE271407 BG164046 AK023979 BG108458 BX443546 BG617393 BM457635
GeneLoc Exon Structure
|
Expression
for LIN52 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LIN52 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for LIN52
SOURCE GeneReport for Unigene cluster: Hs.612866
SABiosciences Custom PCR Arrays for LIN52
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIN52
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LIN52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIN52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIN52 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIN52 |
Orthologs
for LIN52 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LIN52 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Lin521 , 5 |
lin-52 homolog (C. elegans)1, 5 |
91.38(n)1
100(a)1 |
|
12 (39.22 cM)5
2177081 NM_173756.41 NP_776117.11
844515085 |
chicken
(Gallus gallus) |
Aves |
LIN521 |
lin-52 homolog (C. elegans) |
78.57(n)
95.54(a) |
|
423346 NM_001007937.1 NP_001007938.1 |
lizard
(Anolis carolinensis) |
Reptilia |
LIN526 |
-- |
97(a) |
1 ↔ 1 |
1(23666400-23717696) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.150972 |
Transcribed sequence with weak similarity to protein more |
76.23(n) |
|
AL969102.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.165392 |
Transcribed sequences |
79.92(n) |
|
BI318394.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
lin-526 |
lin-52 |
24(a) |
1 ↔ 1 |
X(5648062-5648917) |
ENSEMBL Gene Tree for LIN52 (if available)
TreeFam Gene Tree for LIN52 (if available) |
Paralogs
for LIN52 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LIN52 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LIN52 (74551499 - 74667936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for LIN52
6 CNVs: 66668 66669 30659 76676 3055 101981
1 Indel: 101982 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIN52 |
|
Disorders
/ Diseases
for LIN52 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LIN52 for disorders About GeneDecksing
2  diseases for LIN52: About MalaCardspostpartum depression retinitis
Human Genome Epidemiology (HuGE) Navigator: LIN52 (1 document)
Export disorders for LIN52 gene to outside databases
|
Publications
for LIN52 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LIN52 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with LIN52) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PubMed id 17531812)1, 2 Litovchick L.... DeCaprio J.A. (2007)
- LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PubMed id 17671431)1, 2 Schmit F.... Gaubatz S. (2007)
- Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. (PubMed id 17075059)1, 3 Harrison M.M....Horvitz H.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A kinase shRNA screen links LATS2 and the pRB tumor s uppressor. (PubMed id 21498571)1 TschAPp K....Dyson N. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)1 Eriksson N....Mountain J. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for LIN52 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LIN52 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LIN52 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LIN52 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LIN52 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LIN52 gene:
Search GeneIP for patents involving LIN52
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LIN52 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LIN52 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIN52 | | | OriGene Protein Over-expression Lysate for LIN52 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LIN52 | | OriGene 3'-UTR Clone for LIN52 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIN52 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LIN52 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LIN52 | | OriGene Custom Protein Services for LIN52 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LIN52 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LIN52 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIN52 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIN52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIN52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIN52 |
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 |  |  |  | |
| | | | Search Tocris compounds for LIN52 |
| |  |  |  |  | | | | |
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 |
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 | | | LIN52 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIN52 |
|  |  |  | | | | Search ThermoFisher Antibodies for LIN52 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIN52 |
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