Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LIN37 Gene

Aliases for LIN37 Gene

  • Lin-37 DREAM MuvB Core Complex Component 2 3 5
  • Antolefinin 3 4
  • Lin-37 Homolog (C. Elegans) 2
  • Protein Lin-37 Homolog 3
  • Lin-37 Homolog 3
  • Protein F25965 3
  • ZK418.4 3
  • F25965 3
  • Lin-37 3

External Ids for LIN37 Gene

Previous GeneCards Identifiers for LIN37 Gene

  • GC19P040944
  • GC19P040946
  • GC19P040949
  • GC19P040951
  • GC19P040953
  • GC19P040955
  • GC19P036239
  • GC19P032744
  • GC19P035803
  • GC19P035832
  • GC19P035989
  • GC19P036012
  • GC19P036175
  • GC19P036253

Summaries for LIN37 Gene

Entrez Gene Summary for LIN37 Gene

  • This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIN37 Gene

LIN37 (Lin-37 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cellular senescence (KEGG).

Additional gene information for LIN37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN37 Gene

Genomics for LIN37 Gene

Regulatory Elements for LIN37 Gene

Enhancers for LIN37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H035246 1.4 ENCODE dbSUPER 30.8 -499.7 -499737 3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC RBM42 HAUS5 TMEM147-AS1 ZNF599 KIAA0355 KMT2B ZNF30 ZNF792 ZNF302 PROSER3
GH19H036572 1.2 ENCODE 19.6 +825.1 825148 2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF790-AS1 ZNF567 ZFP82 ZNF527 ZNF585A LINC01534 ZNF793 ZNF529 ZNF383 ZNF420
GH19H035208 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -535.9 -535937 7 PKNOX1 FOXA2 FEZF1 ZNF2 SP3 SP5 JUNB ZNF592 MEF2D SREBF1 ZNF599 TMEM147-AS1 KIAA0355 HAUS5 PROSER3 RBM42 MAG ZNF792 SDHAF1 USF2
GH19H035202 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -542.8 -542820 6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF766 CBX5 ZNF143 ZNF207 FOS ZNF599 KIAA0355 FXYD5 TMEM147-AS1 HAUS5 ZNF792 USF2 ENSG00000271049 FAM187B LSR
GH19H035710 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -33.2 -33169 9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF529 ZFP82 U2AF1L4 ZNF567 TMEM147-AS1 RBM42 LINC00665 ZNF461 PROSER3 ZNF529-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIN37 on UCSC Golden Path with GeneCards custom track

Promoters for LIN37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109060 439 1201 FOXA2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Location for LIN37 Gene

Chromosome:
19
Start:
35,748,361 bp from pter
End:
35,754,519 bp from pter
Size:
6,159 bases
Orientation:
Plus strand

Genomic View for LIN37 Gene

Genes around LIN37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN37 Gene

Proteins for LIN37 Gene

  • Protein details for LIN37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GY3-LIN37_HUMAN
    Recommended name:
    Protein lin-37 homolog
    Protein Accession:
    Q96GY3
    Secondary Accessions:
    • A8KAQ1
    • O14557
    • Q7Z2T9

    Protein attributes for LIN37 Gene

    Size:
    246 amino acids
    Molecular mass:
    28383 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
    SequenceCaution:
    • Sequence=AAB81199.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LIN37 Gene

Post-translational modifications for LIN37 Gene

  • Ubiquitination at posLast=9898
  • Modification sites at PhosphoSitePlus

Other Protein References for LIN37 Gene

No data available for DME Specific Peptides for LIN37 Gene

Domains & Families for LIN37 Gene

Gene Families for LIN37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LIN37 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LIN37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LIN37: view

No data available for UniProtKB/Swiss-Prot for LIN37 Gene

Function for LIN37 Gene

Gene Ontology (GO) - Molecular Function for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LIN37: view
genes like me logo Genes that share phenotypes with LIN37: view

Animal Model Products

CRISPR Products

miRNA for LIN37 Gene

miRTarBase miRNAs that target LIN37

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIN37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN37 Gene

Localization for LIN37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN37 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with LIN37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN37 Gene

Pathways & Interactions for LIN37 Gene

genes like me logo Genes that share pathways with LIN37: view

Pathways by source for LIN37 Gene

1 KEGG pathway for LIN37 Gene

Gene Ontology (GO) - Biological Process for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN37: view

No data available for SIGNOR curated interactions for LIN37 Gene

Drugs & Compounds for LIN37 Gene

No Compound Related Data Available

Transcripts for LIN37 Gene

Unigene Clusters for LIN37 Gene

Lin-37 homolog (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LIN37
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LIN37 Gene

No ASD Table

Relevant External Links for LIN37 Gene

GeneLoc Exon Structure for
LIN37
ECgene alternative splicing isoforms for
LIN37

Expression for LIN37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIN37 Gene

Protein differential expression in normal tissues from HIPED for LIN37 Gene

This gene is overexpressed in CD8 Tcells (27.1), Testis (26.4), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIN37 Gene



Protein tissue co-expression partners for LIN37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIN37 Gene:

LIN37

SOURCE GeneReport for Unigene cluster for LIN37 Gene:

Hs.529100

Evidence on tissue expression from TISSUES for LIN37 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with LIN37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIN37 Gene

Orthologs for LIN37 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIN37 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia LIN37 33 34
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia LIN37 33 34
  • 90.79 (n)
mouse
(Mus musculus)
Mammalia Lin37 33 16 34
  • 87.4 (n)
rat
(Rattus norvegicus)
Mammalia Lin37 33
  • 86.99 (n)
oppossum
(Monodelphis domestica)
Mammalia LIN37 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIN37 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lin37 33
  • 62.57 (n)
zebrafish
(Danio rerio)
Actinopterygii lin37 33 34
  • 59.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta mip40 34
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToOne
Species where no ortholog for LIN37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIN37 Gene

ENSEMBL:
Gene Tree for LIN37 (if available)
TreeFam:
Gene Tree for LIN37 (if available)

Paralogs for LIN37 Gene

No data available for Paralogs for LIN37 Gene

Variants for LIN37 Gene

Sequence variations from dbSNP and Humsavar for LIN37 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000515261 -- 35,748,030(+) ATTAG(C/G)GCAGG upstream-variant-2KB
rs1000870939 -- 35,752,664(+) CCCCA(C/T)GGGTA intron-variant
rs1001123270 -- 35,746,666(+) GAGAG(A/C)AGCCG intron-variant, upstream-variant-2KB
rs1001557618 -- 35,751,689(+) TACCT(C/T)TAAGG intron-variant
rs1002334305 -- 35,752,122(+) AGCTG(C/T)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIN37 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781
nsv953286 CNV deletion 24416366

Variation tolerance for LIN37 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIN37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIN37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN37 Gene

Disorders for LIN37 Gene

Relevant External Links for LIN37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIN37

No disorders were found for LIN37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN37 Gene

Publications for LIN37 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L … DeCaprio JA (Genes & development 2011) 2 3 60
  2. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L … DeCaprio JA (Molecular cell 2007) 3 4 60
  3. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PMID: 17671431) Schmit F … Gaubatz S (Cell cycle (Georgetown, Tex.) 2007) 3 4 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for LIN37 Gene

Sources for LIN37 Gene

Content
Loading form....