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Aliases for LIN37 Gene

Aliases for LIN37 Gene

  • Lin-37 DREAM MuvB Core Complex Component 2 3 5
  • Antolefinin 3 4
  • Lin-37 Homolog (C. Elegans) 2
  • Protein Lin-37 Homolog 3
  • Lin-37 Homolog 3
  • Protein F25965 3
  • ZK418.4 3
  • F25965 3
  • Lin-37 3

External Ids for LIN37 Gene

Previous GeneCards Identifiers for LIN37 Gene

  • GC19P040944
  • GC19P040946
  • GC19P040949
  • GC19P040951
  • GC19P040953
  • GC19P040955
  • GC19P036239
  • GC19P032744
  • GC19P035803
  • GC19P035832
  • GC19P035989
  • GC19P036012

Summaries for LIN37 Gene

Entrez Gene Summary for LIN37 Gene

  • This gene encodes a protein expressed in the eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for LIN37 Gene

LIN37 (Lin-37 DREAM MuvB Core Complex Component) is a Protein Coding gene. Among its related pathways are Cell cycle Cell cycle (generic schema) and Regulation of PLK1 Activity at G2/M Transition.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIN37 Gene

Genomics for LIN37 Gene

Regulatory Elements for LIN37 Gene

Enhancers for LIN37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035208 1.8 FANTOM5 Ensembl ENCODE 9.9 -535.0 -535036 8.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF416 ZNF207 TMEM147-AS1 HAUS5 KMT2B KIAA0355 ZNF792 RBM42 ENSG00000267049 ENSG00000268947 LINC01766 ENSG00000270544
GH19F035316 1.8 FANTOM5 Ensembl ENCODE 9.9 -429.6 -429574 5.2 HDGF PKNOX1 MLX SIN3A ZNF2 ZNF48 SLC30A9 ZNF121 FOS ZNF263 MAG TMEM147-AS1 HAUS5 KMT2B SDHAF1 ZNF792 LIN37 CD22 FFAR3 FFAR2
GH19F035202 1.7 FANTOM5 Ensembl ENCODE 9.9 -542.8 -542820 6.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF302 TMEM147-AS1 RBM42 ZNF792 KIAA0355 HAUS5 KMT2B ENSG00000267049 SDHAF1 LRFN3 LOC101927572
GH19F035066 1.6 FANTOM5 Ensembl ENCODE 9.9 -680.3 -680323 3.2 ATF1 PKNOX1 ARID4B FEZF1 ZNF2 GLIS2 ZNF143 KLF7 KLF13 ZNF263 TMEM147-AS1 ZNF792 KMT2B RBM42 SDHAF1 HPN ENSG00000271032 LSM14A SCN1B ENSG00000267049
GH19F035958 1.3 FANTOM5 Ensembl ENCODE 11.6 +211.0 211040 1.2 RING1 CTCF KLF1 SUZ12 ZIC2 ZFHX2 ZNF366 EGR1 ZNF169 CREM ZNF567 ZNF790-AS1 ZNF790 ZNF529-AS1 ZNF461 LINC01534 ZFP14 ZNF529 ZNF568 ZNF260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIN37 on UCSC Golden Path with GeneCards custom track

Promoters for LIN37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418958 439 1601 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for LIN37 Gene

35,748,361 bp from pter
35,754,519 bp from pter
6,159 bases
Plus strand

Genomic View for LIN37 Gene

Genes around LIN37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIN37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIN37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIN37 Gene

Proteins for LIN37 Gene

  • Protein details for LIN37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lin-37 homolog
    Protein Accession:
    Secondary Accessions:
    • A8KAQ1
    • O14557
    • Q7Z2T9

    Protein attributes for LIN37 Gene

    246 amino acids
    Molecular mass:
    28383 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
    • Sequence=AAB81199.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LIN37 Gene

Post-translational modifications for LIN37 Gene

  • Ubiquitination at Lys 98
  • Modification sites at PhosphoSitePlus

Other Protein References for LIN37 Gene

No data available for DME Specific Peptides for LIN37 Gene

Domains & Families for LIN37 Gene

Protein Domains for LIN37 Gene


Suggested Antigen Peptide Sequences for LIN37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LIN37: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LIN37 Gene

Function for LIN37 Gene

Gene Ontology (GO) - Molecular Function for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LIN37: view
genes like me logo Genes that share phenotypes with LIN37: view

Animal Model Products

miRNA for LIN37 Gene

miRTarBase miRNAs that target LIN37

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIN37 Gene

Localization for LIN37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIN37 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IEA --
genes like me logo Genes that share ontologies with LIN37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LIN37 Gene

Pathways & Interactions for LIN37 Gene

genes like me logo Genes that share pathways with LIN37: view

Pathways by source for LIN37 Gene

Gene Ontology (GO) - Biological Process for LIN37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with LIN37: view

No data available for SIGNOR curated interactions for LIN37 Gene

Transcripts for LIN37 Gene

Unigene Clusters for LIN37 Gene

Lin-37 homolog (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIN37 Gene

No ASD Table

Relevant External Links for LIN37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIN37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LIN37 Gene

Protein differential expression in normal tissues from HIPED for LIN37 Gene

This gene is overexpressed in CD8 Tcells (27.1), Testis (26.4), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIN37 Gene

Protein tissue co-expression partners for LIN37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LIN37 Gene:


SOURCE GeneReport for Unigene cluster for LIN37 Gene:

genes like me logo Genes that share expression patterns with LIN37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LIN37 Gene

Orthologs for LIN37 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIN37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LIN37 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia LIN37 34 35
  • 92.28 (n)
(Bos Taurus)
Mammalia LIN37 34 35
  • 90.79 (n)
(Mus musculus)
Mammalia Lin37 34 16 35
  • 87.4 (n)
(Rattus norvegicus)
Mammalia Lin37 34
  • 86.99 (n)
(Monodelphis domestica)
Mammalia LIN37 35
  • 81 (a)
(Anolis carolinensis)
Reptilia LIN37 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lin37 34
  • 62.57 (n)
(Danio rerio)
Actinopterygii lin37 34 35
  • 59.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta mip40 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for LIN37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIN37 Gene

Gene Tree for LIN37 (if available)
Gene Tree for LIN37 (if available)

Paralogs for LIN37 Gene

No data available for Paralogs for LIN37 Gene

Variants for LIN37 Gene

Sequence variations from dbSNP and Humsavar for LIN37 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111278744 -- 35,747,278(+) CTGGA(A/G)TGCAG downstream-variant-500B, upstream-variant-2KB
rs111377092 -- 35,749,807(+) CTCAA(A/G)AAAAA intron-variant
rs111468214 -- 35,754,567(+) GCAGT(A/C/T)GGCAG intron-variant, utr-variant-3-prime
rs111677082 -- 35,750,758(+) AGTTT(A/G)AGATC intron-variant
rs112713388 -- 35,746,963(+) CCCAC(A/G)TTCTC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LIN37 Gene

Variant ID Type Subtype PubMed ID
nsv953286 CNV deletion 24416366
nsv579423 CNV loss 21841781
nsv579422 CNV loss 21841781
nsv515536 CNV loss 19592680

Variation tolerance for LIN37 Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIN37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIN37 Gene

Disorders for LIN37 Gene

Relevant External Links for LIN37

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LIN37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIN37 Gene

Publications for LIN37 Gene

  1. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. (PMID: 21498570) Litovchick L. … DeCaprio J.A. (Genes Dev. 2011) 2 3 64
  2. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. (PMID: 17531812) Litovchick L. … DeCaprio J.A. (Mol. Cell 2007) 3 4 64
  3. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. (PMID: 17671431) Schmit F. … Gaubatz S. (Cell Cycle 2007) 3 4 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LIN37 Gene

Sources for LIN37 Gene

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