Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LIMS3 Gene

Aliases for LIMS3 Gene

  • LIM And Senescent Cell Antigen-Like Domains 3 2 3
  • Particularly Interesting New Cys-His Protein 3 3 4
  • Pinch 2 2 3
  • PINCH-3 3 4
  • LIM And Senescent Cell Antigen-Like-Containing Domain Protein 3 3
  • PINCH3 4

External Ids for LIMS3 Gene

Previous GeneCards Identifiers for LIMS3 Gene

  • GC02P110392
  • GC02P110013
  • GC02P110656

Summaries for LIMS3 Gene

GeneCards Summary for LIMS3 Gene

LIMS3 (LIM And Senescent Cell Antigen-Like Domains 3) is a Protein Coding gene. An important paralog of this gene is LDB3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMS3 Gene

Genomics for LIMS3 Gene

Regulatory Elements for LIMS3 Gene

Genomic Location for LIMS3 Gene

109,898,428 bp from pter
109,925,625 bp from pter
27,198 bases
Plus strand

Genomic View for LIMS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMS3 Gene

Proteins for LIMS3 Gene

  • Protein details for LIMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 3
    Protein Accession:
    Secondary Accessions:
    • B4DPH6
    • Q9HB10

    Protein attributes for LIMS3 Gene

    117 amino acids
    Molecular mass:
    13251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIMS3 Gene


neXtProt entry for LIMS3 Gene

Proteomics data for LIMS3 Gene at MOPED

Post-translational modifications for LIMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIMS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIMS3 Gene

Domains for LIMS3 Gene

Protein Domains for LIMS3 Gene


Graphical View of Domain Structure for InterPro Entry



  • P0CW19
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with LIMS3: view

No data available for Gene Families for LIMS3 Gene

Function for LIMS3 Gene

Gene Ontology (GO) - Molecular Function for LIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LIMS3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIMS3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LIMS3 Gene

Localization for LIMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMS3 Gene


Subcellular locations from

Jensen Localization Image for LIMS3 Gene COMPARTMENTS Subcellular localization image for LIMS3 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for LIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LIMS3: view

Pathways for LIMS3 Gene

SuperPathways for LIMS3 Gene

No Data Available

Interacting Proteins for LIMS3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000405165 for LIMS3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LIMS3 Gene


No data available for Pathways by source for LIMS3 Gene

Transcripts for LIMS3 Gene

mRNA/cDNA for LIMS3 Gene

Unigene Clusters for LIMS3 Gene

LIM and senescent cell antigen-like domains 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIMS3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIMS3 Gene

No ASD Table

Relevant External Links for LIMS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIMS3 Gene

mRNA expression in normal human tissues for LIMS3 Gene

mRNA differential expression in normal tissues according to GTEx for LIMS3 Gene

This gene is overexpressed in Artery - Aorta (8.2) and Muscle - Skeletal (7.3).

Protein differential expression in normal tissues for LIMS3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LIMS3 Gene

SOURCE GeneReport for Unigene cluster for LIMS3 Gene Hs.535619

mRNA Expression by UniProt/SwissProt for LIMS3 Gene

Tissue specificity: Detected in testis.
genes like me logo Genes that share expressions with LIMS3: view

Expression partners for LIMS3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LIMS3 Gene

Orthologs for LIMS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MGC142792 36
  • 15 (a)
(Canis familiaris)
Mammalia -- 36
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
(Mus musculus)
Mammalia Lims1 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
(Gallus gallus)
Aves -- 36
-- 36
-- 36
-- 36
LIMS1 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
(Danio rerio)
Actinopterygii lims1 36
  • 15 (a)
lims2 36
  • 15 (a)
fruit fly
(Drosophila melanogaster)
Insecta stck 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea unc-97 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11312 36
  • 12 (a)
Species with no ortholog for LIMS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LIMS3 Gene

Gene Tree for LIMS3 (if available)
Gene Tree for LIMS3 (if available)

Paralogs for LIMS3 Gene

Paralogs for LIMS3 Gene

Selected SIMAP similar genes for LIMS3 Gene using alignment to 2 proteins: Pseudogenes for LIMS3 Gene

genes like me logo Genes that share paralogs with LIMS3: view

Variants for LIMS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LIMS3 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv469649 CNV Complex 16826518
nsv508157 CNV Loss 20534489
esv28875 CNV Gain+Loss 19812545

Relevant External Links for LIMS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LIMS3 Gene

Disorders for LIMS3 Gene

No disorders were found for LIMS3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LIMS3 Gene

Publications for LIMS3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LIMS3 Gene

Sources for LIMS3 Gene

Back to Top