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Aliases for LIMS3 Gene

Aliases for LIMS3 Gene

  • LIM Zinc Finger Domain Containing 3 2 3
  • LIM And Senescent Cell Antigen-Like Domains 3 2 3 5
  • Particularly Interesting New Cys-His Protein 3 3 4
  • LIM-Type Zinc Finger Domains 3 2 3
  • Pinch 2 2 3
  • PINCH-3 3 4
  • PINCH3 4

External Ids for LIMS3 Gene

Previous GeneCards Identifiers for LIMS3 Gene

  • GC02P110392
  • GC02P110013
  • GC02P110656

Summaries for LIMS3 Gene

GeneCards Summary for LIMS3 Gene

LIMS3 (LIM Zinc Finger Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is LDB3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMS3 Gene

Genomics for LIMS3 Gene

Regulatory Elements for LIMS3 Gene

Promoters for LIMS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIMS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LIMS3 Gene

Chromosome:
2
Start:
109,898,428 bp from pter
End:
109,925,625 bp from pter
Size:
27,198 bases
Orientation:
Plus strand

Genomic View for LIMS3 Gene

Genes around LIMS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIMS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMS3 Gene

Proteins for LIMS3 Gene

  • Protein details for LIMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CW19-LIMS3_HUMAN
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 3
    Protein Accession:
    P0CW19
    Secondary Accessions:
    • B4DPH6
    • Q9HB10

    Protein attributes for LIMS3 Gene

    Size:
    117 amino acids
    Molecular mass:
    13251 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LIMS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMS3 Gene

Proteomics data for LIMS3 Gene at MOPED

Post-translational modifications for LIMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LIMS3 Gene

No data available for DME Specific Peptides for LIMS3 Gene

Domains & Families for LIMS3 Gene

Protein Domains for LIMS3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0CW19

UniProtKB/Swiss-Prot:

LIMS3_HUMAN :
  • Contains 1 LIM zinc-binding domain.
Domain:
  • Contains 1 LIM zinc-binding domain.
genes like me logo Genes that share domains with LIMS3: view

Function for LIMS3 Gene

Phenotypes for LIMS3 Gene

GenomeRNAi human phenotypes for LIMS3:
genes like me logo Genes that share phenotypes with LIMS3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LIMS3 Gene

Localization for LIMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMS3 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LIMS3 Gene

Pathways & Interactions for LIMS3 Gene

SuperPathways for LIMS3 Gene

No Data Available

Interacting Proteins for LIMS3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405165%0d%0a9606.ENSP00000232014%0d%0a
Selected Interacting proteins: ENSP00000405165 for LIMS3 Gene via STRING

Symbol External ID(s) Details
BCL6

Gene Ontology (GO) - Biological Process for LIMS3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LIMS3 Gene

Drugs & Compounds for LIMS3 Gene

No Compound Related Data Available

Transcripts for LIMS3 Gene

Unigene Clusters for LIMS3 Gene

LIM and senescent cell antigen-like domains 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIMS3 Gene

No ASD Table

Relevant External Links for LIMS3 Gene

GeneLoc Exon Structure for
LIMS3
ECgene alternative splicing isoforms for
LIMS3

Expression for LIMS3 Gene

mRNA expression in normal human tissues for LIMS3 Gene

mRNA differential expression in normal tissues according to GTEx for LIMS3 Gene

This gene is overexpressed in Artery - Aorta (x8.2) and Muscle - Skeletal (x7.3).

Protein differential expression in normal tissues from HIPED for LIMS3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LIMS3 Gene



SOURCE GeneReport for Unigene cluster for LIMS3 Gene Hs.535619

mRNA Expression by UniProt/SwissProt for LIMS3 Gene

P0CW19-LIMS3_HUMAN
Tissue specificity: Detected in testis.
genes like me logo Genes that share expression patterns with LIMS3: view

Protein tissue co-expression partners for LIMS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LIMS3 Gene

Orthologs for LIMS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGC142792 36
  • 15 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 26 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 15 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lims1 36
  • 27 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
LIMS1 36
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lims1 36
  • 15 (a)
ManyToMany
lims2 36
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta stck 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-97 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11312 36
  • 12 (a)
OneToMany
Species with no ortholog for LIMS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LIMS3 Gene

ENSEMBL:
Gene Tree for LIMS3 (if available)
TreeFam:
Gene Tree for LIMS3 (if available)

Paralogs for LIMS3 Gene

(7) SIMAP similar genes for LIMS3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LIMS3 Gene

genes like me logo Genes that share paralogs with LIMS3: view

Variants for LIMS3 Gene

Structural Variations from Database of Genomic Variants (DGV) for LIMS3 Gene

Variant ID Type Subtype PubMed ID
nsv874777 CNV Gain 21882294
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv469649 CNV Complex 16826518
nsv508157 CNV Loss 20534489
esv28875 CNV Gain+Loss 19812545

Relevant External Links for LIMS3 Gene

HapMap Linkage Disequilibrium report
LIMS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for LIMS3 Gene

Disorders for LIMS3 Gene

Relevant External Links for LIMS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIMS3

No disorders were found for LIMS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIMS3 Gene

Publications for LIMS3 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Molecular cloning and characterization of a novel splice variant of the LIM domain family gene, PINCH 2, in human testis. (PMID: 17435276) Liu Y. … Li J. (Mol. Biotechnol. 2007) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for LIMS3 Gene

Sources for LIMS3 Gene

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