Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIMS2 Gene

protein-coding   GIFtS: 55
GCID: GC02M128395

LIM And Senescent Cell Antigen-Like Domains 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM And Senescent Cell Antigen-Like Domains 21 2     LIM-Like Protein 22 3
Particularly Interesting New Cys-His Protein 22 3     ILK-Binding Protein2
PINCH-22 3     LIM And Senescent Cell Antigen-Like-Containing Domain Protein 22
PINCH22 3     

External Ids:    HGNC: 160841   Entrez Gene: 556792   Ensembl: ENSG000000721637   OMIM: 6079085   UniProtKB: Q7Z4I73   

Export aliases for LIMS2 gene to outside databases

Previous GC identifers: GC02M125694 GC02M126320 GC02M128300 GC02M128489 GC02M128112 GC02M120702


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIMS2 Gene:
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked
kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein
has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape
and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for LIMS2 Gene: 
LIMS2 (LIM and senescent cell antigen-like domains 2) is a protein-coding gene. Diseases associated with LIMS2 include hepatitis b, and gastric cancer, and among its related super-pathways are Cell-cell junction organization and Cytoskeleton remodeling Reverse signaling by ephrin B. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot: LIMS2_HUMAN, Q7Z4I7
Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell
spreading and migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIMS2 gene promoter:
         STAT1   STAT2   STAT3   STAT1beta   POU3F2   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIMS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LIMS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.3   Ensembl cytogenetic band:  2q14.3   HGNC cytogenetic band: 2q21.1

LIMS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMS2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M128395:  view genomic region     (about GC identifiers)

Start:
128,395,956 bp from pter      End:
128,439,360 bp from pter
Size:
43,405 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIMS2_HUMAN, Q7Z4I7 (See protein sequence)
Recommended Name: LIM and senescent cell antigen-like-containing domain protein 2  
Size: 341 amino acids; 38916 Da
Subunit: Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the
first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of
integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA
Subcellular location: Nucleus (Potential). Cell junction, focal adhesion. Cell membrane; Peripheral membrane
protein; Cytoplasmic side
Sequence caution: Sequence=AAM77350.1; Type=Frameshift; Positions=331;
1 PDB 3D structure from and Proteopedia for LIMS2:
3IXE (3D)    
Secondary accessions: A6NLH0 B4DMV1 F5H6E6 Q7Z4I2 Q7Z4I6 Q7Z4I8 Q8NFE7 Q9HA13
Alternative splicing: 5 isoforms:  Q7Z4I7-1   Q7Z4I7-2   Q7Z4I7-3   Q7Z4I7-4   Q7Z4I7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIMS2: NX_Q7Z4I7

Explore proteomics data for LIMS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z4I7

  • LIMS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIMS2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001129509.2  NP_001154875.1  NP_001154876.1  NP_001243471.1  NP_060450.2  

    ENSEMBL proteins: 
     ENSP00000397253   ENSP00000386252   ENSP00000386345   ENSP00000326888   ENSP00000386383  
     ENSP00000347240   ENSP00000386637   ENSP00000387002   ENSP00000386570   ENSP00000443794  
     ENSP00000388611   ENSP00000386907  
    Reactome Protein details: Q7Z4I7
    Human Recombinant Protein Products for LIMS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LIMS2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LIMS2
    GenScript Custom Purified and Recombinant Proteins Services for LIMS2
    Novus Biologicals LIMS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIMS2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005925focal adhesion IEA--

    LIMS2 for ontologies           About GeneDecksing



    LIMS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LIMS2
    GenScript Custom Superior Antibodies Services for LIMS2
    Abcam antibodies for LIMS2
    Cloud-Clone Corp. Antibodies for LIMS2 
    Search ThermoFisher Antibodies for LIMS2
    LSBio Antibodies in human, mouse, rat for LIMS2 

    Assay Products for LIMS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIMS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LIMS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIMS2 
    Cloud-Clone Corp. CLIAs for LIMS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017351 PINCH
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q7Z4I7

    ProtoNet protein and cluster: Q7Z4I7

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMS2_HUMAN, Q7Z4I7
    Similarity: Contains 5 LIM zinc-binding domains


    LIMS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMS2_HUMAN, Q7Z4I7
    Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
    complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell
    spreading and migration

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    LIMS2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lims2):
     cardiovascular system  growth/size  homeostasis/metabolism  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  normal  respiratory system 

    LIMS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lims2tm1.1Ref for LIMS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIMS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIMS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIMS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIMS2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIMS2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMS2 (see all 9):
    hsa-miR-205 hsa-miR-4289 hsa-miR-4254 hsa-miR-3614-3p hsa-miR-4306 hsa-miR-1291 hsa-miR-3150b-3p hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidLIMS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIMS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIMS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIMS2
    Sirion Biotech Customized adenovirus for overexpression of LIMS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LIMS2 (see all 26)
    OriGene ORF clones in mouse, rat for LIMS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): LIMS2 (NM_017980)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS2
    Sirion Biotech Customized lentivirus for stable overexpression of LIMS2 
                         Customized lentivirus expression plasmids for stable overexpression of LIMS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIMS2
    Search LifeMap BioReagents cell lines for LIMS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LIMS2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    2Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    3Rho Family GTPases
    ILK Signaling0.49
    4Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Cell-extracellular matrix interactions0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for LIMS2
        Cytoskeleton remodeling Reverse signaling by ephrin B

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LIMS2
        ILK Signaling

    1 GeneGo (Thomson Reuters) Pathway for LIMS2
        Cytoskeleton remodeling Reverse signaling by ephrin B

    3        Reactome Pathways for LIMS2
        Cell-extracellular matrix interactions
    Cell junction organization
    Cell-Cell communication



    LIMS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LIMS2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for LIMS2 (Q7Z4I72, 3 ENSP000003268884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3MINT-61747 I2D: score=3 
    ILKQ134183, ENSP000002994214I2D: score=2 STRING: ENSP00000299421
    PARVAENSP000003340084STRING: ENSP00000334008
    RSU1ENSP000003395214STRING: ENSP00000339521
    --Q9WMX22MINT-7050182
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0034329cell junction assembly TAS--
    GO:0045216cell-cell junction organization IEA--
    GO:2001046positive regulation of integrin-mediated signaling pathway IEA--

    LIMS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIMS2

    Search CenterWatch for drugs/clinical trials and news about LIMS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIMS2 gene (5 alternative transcripts): 
    NM_001136037.2  NM_001161403.1  NM_001161404.1  NM_001256542.1  NM_017980.4  

    Unigene Cluster for LIMS2:

    LIM and senescent cell antigen-like domains 2
    Hs.469881  [show with all ESTs]
    Unigene Representative Sequence: AK095790
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426981 ENST00000469300 ENST00000494613 ENST00000409286 ENST00000409754(uc002tov.3)
    ENST00000476932(uc010fmb.3) ENST00000324938(uc002tox.3) ENST00000484252
    ENST00000466410 ENST00000409455(uc002toy.3) ENST00000355119(uc002tpa.3)
    ENST00000409808(uc010yzm.2 uc002toz.3) ENST00000410011(uc002tpb.3)
    ENST00000410038(uc002tow.3) ENST00000545738 ENST00000413578 ENST00000409254
    ENST00000582671
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIMS2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMS2 (see all 9):
    hsa-miR-205 hsa-miR-4289 hsa-miR-4254 hsa-miR-3614-3p hsa-miR-4306 hsa-miR-1291 hsa-miR-3150b-3p hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidLIMS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LIMS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIMS2
    Clone
    Products:
         
    OriGene clones in human, mouse for LIMS2 (see all 26)
    OriGene ORF clones in mouse, rat for LIMS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): LIMS2 (NM_017980)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS2
    Sirion Biotech Customized lentivirus for stable overexpression of LIMS2 
                         Customized lentivirus expression plasmids for stable overexpression of LIMS2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LIMS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIMS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIMS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMS2

    Additional mRNA sequence: 

    AF484961.1 AF527764.1 AF527765.1 AF527766.1 AF527768.1 AF527770.1 AK000906.1 AK022470.1 
    AK055363.1 AK095790.1 AK297645.1 AL512716.1 BC008977.1 BC065816.1 

    23 DOTS entries:

    DT.424776  DT.100677887  DT.121020405  DT.100795357  DT.100682515  DT.100795353  DT.100809777  DT.100795359 
    DT.410071  DT.105541  DT.97843270  DT.100024465  DT.40125549  DT.100028849  DT.100831216  DT.95218616 
    DT.100795352  DT.102827607  DT.91701677  DT.95218614  DT.100795358  DT.100795360  DT.121020368 

    24/194 AceView cDNA sequences (see all 194):

    BM670177 AF527765 BU617132 BG982661 BE327863 AF527769 BM700170 CR613400 
    AI425075 BQ771641 BC001370 BF527088 AI194056 AU117297 AI056464 BU687389 
    AF520987 AI656165 Z42656 AF527766 BF346205 BC065816 BF512163 AK123014 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for LIMS2 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ·
    SP1:                                                                                            -           -     -                       -           -     -   
    SP2:                                                                    -     -     -     -     -           -     -                       -           -     -   
    SP3:                                                                                -     -     -           -     -                       -           -     -   
    SP4:                                                                    -     -     -     -     -           -     -                                             
    SP5:                                                                    -     -     -     -     -           -     -                       -                     

    ExUns: 14c ^ 15a · 15b ^ 16a · 16b · 16c · 16d
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for LIMS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIMS2 expression in normal human tissues (normalized intensities)      LIMS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATGGAGG
    LIMS2 Expression
    About this image


    LIMS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Fibroblast
             X-gene Foreskin Fibroblasts   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             myometrium   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-101
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   

    See LIMS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIMS2

    SOURCE GeneReport for Unigene cluster: Hs.469881
        SABiosciences Custom PCR Arrays for LIMS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LIMS2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIMS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIMS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIMS2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lims21 , 5 LIM and senescent cell antigen like domains 21, 5 88.69(n)1
    91.37(a)1
      18 (17.89 cM)5
    2253411  NM_144862.31  NP_659111.11 
     319315075 
    chicken
    (Gallus gallus)
    Aves LIMS21 LIM and senescent cell antigen-like domains 2 81.31(n)
    90.61(a)
      424752  XM_003641758.1  XP_003641806.1 
    lizard
    (Anolis carolinensis)
    Reptilia LIMS26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    3(36201683-36229936)
    fruit fly
    (Drosophila melanogaster)
    Insecta stck6
    steamer duck
    62(a)
    1 → many
    3R(4182689-4185686)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-976
    pin-26
    LIM domain-containing protein pin-2
    57(a)
    35(a)
    1 ↔ many
    possible ortholog
    X(5593133-5594965)
    IV(12793853-12796163)


    ENSEMBL Gene Tree for LIMS2 (if available)
    TreeFam Gene Tree for LIMS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIMS2 gene
    ABLIM32  LIMS12  LIMS3L2  DMTN2  LDB32  FHL52  LPXN2  PDLIM52  
    ENSG000002572072  ABLIM22  FHL22  ABLIM12  PDLIM72  FHL32  FHL12  LIMS32  
    TGFB1I12  PXN2  
    18/20 SIMAP similar genes for LIMS2 using alignment to 5 protein entries:     LIMS2_HUMAN (see all proteins) (see all similar genes):
    DKFZp547D192    LIMS3    LIMS3L    LIMS1    LPP    ABLIM3
    TRIP6    TRIP6i1    PXN    AJUBA    LDB3    LMX1B
    PRICKLE2    CRIP1    LHX4    LMO1    ABLIM1    CSRP1

    LIMS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LIMS2
    PGOHUM00000245496


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/846 SNPs in LIMS2 are shown (see all 846)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478177451,2
    --128395885(+) CCTGAA/CCTCGT 5 -- int10--------
    rs3677334031,2
    C--128395899(+) GTCTA-/TGTC  
            
    TGTCT
    5 -- int10--------
    rs342462421,2
    C--128396037(+) AAACA-/AAA   
      C
    /AACA
    CCAGG
    10 -- ut311NA 2
    rs3676414861,2
    C--128396038(+) AAACA-/AACA  
            
    CCAGG
    5 -- ut310--------
    rs717378641,2
    C--128396046(+) AACAA-/AAC   
      A
    /ACAC
    ACACC
    10 -- ut310--------
    rs10551991,2
    --128396059(-) CCAGCG/CCAGAC 5 -- ut31 ese35Minor allele frequency- C:0.11CSA WA NA EA 361
    rs576520111,2
    C,F--128396067(+) TGGCCG/AAAGAC 5 -- ut311Minor allele frequency- A:0.01WA 118
    rs1398126381,2
    --128396070(+) CCGAAA/GACGAA 5 -- ut310--------
    rs780225021,2
    C,F--128396167(+) GACACA/CAGCCC 5 -- ut312Minor allele frequency- C:0.05WA NA 238
    rs1147294121,2
    C,F--128396180(+) AGGTCG/AGGGGG 5 -- ut311Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for LIMS2 (128395956 - 128439360 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for LIMS2 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508864CNV Insertion20534489
    nsv517532CNV Loss19592680
    dgv4298n71CNV Loss21882294
    nsv875030CNV Loss21882294
    nsv470482CNV Loss18288195
    nsv875033CNV Loss21882294
    dgv4301n71CNV Loss21882294
    nsv518085CNV Loss19592680
    dgv4300n71CNV Loss21882294
    nsv875031CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LIMS2
    DNA2.0 Custom Variant and Variant Library Synthesis for LIMS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607908    OMIM disorders: --

    3 diseases for LIMS2:    About MalaCards
    hepatitis b    gastric cancer    hepatitis


    LIMS2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: LIMS2 (1 document)

    Export disorders for LIMS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIMS2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with LIMS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PubMed id 12167643)1, 2 Zhang Y.... Wu C. (2002)
    4. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    5. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PubMed id 23535033)1 Sherva R....Green R.C. (2013)
    6. PINCH-2 expression in cancers involving serosal effus ions using quantitative PCR. (PubMed id 20500520)1 Yuan Y....Davidson B. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    9. Structural basis of competition between PINCH1 and PI NCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. (PubMed id 19963065)2 Chiswell B.P....Calderwood D.A. (2010)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55679 HGNC: 16084 AceView: LIMS2 Ensembl:ENSG00000072163 euGenes: HUgn55679
    ECgene: LIMS2 H-InvDB: LIMS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIMS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIMS2 gene:
    Search GeneIP for patents involving LIMS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LIMS2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for LIMS2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LIMS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for LIMS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LIMS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LIMS2   OriGene Custom Protein Services for LIMS2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LIMS2
     QIAGEN SeqTarget long-range PCR primers for resequencing LIMS2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMS2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LIMS2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMS2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIMS2
     GenScript Custom Purified and Recombinant Proteins Services for LIMS2 GenScript cDNA clones with any tag delivered in your preferred vector for LIMS2
     GenScript Custom Assay Services for LIMS2 GenScript Custom Superior Antibodies Services for LIMS2
     GenScript Custom overexpressing Cell Line Services for LIMS2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LIMS2 promoter
     Search Chromatin IP Primers for LIMS2
     RT2 qPCR Primer Assay in human, mouse, rat LIMS2
     Search GNC Networks for LIMS2
     SABiosciences PCR Arrays including human, mouse, rat LIMS2
     Search Tocris compounds for LIMS2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LIMS2 lysates
     Antibodies for LIMS2
     See all of Abcam's Antibodies, Kits and Proteins for LIMS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LIMS2
     Antibodies for LIMS2
     ELISAs for LIMS2
     CLIAs for LIMS2
     Search LifeMap BioReagents cell lines for LIMS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS2
     SwitchGear 3'UTR luciferase reporter plasmids for LIMS2
     SwitchGear Promoter luciferase reporter plasmids for LIMS2
     Search ThermoFisher Antibodies for LIMS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LIMS2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIMS2
    Customized:
     lentivirus for stable overexpression of LIMS2
     lentivirus expression plasmids for stable overexpression of LIMS2
     adenovirus for overexpression of LIMS2
     LSBio Antibodies in human, mouse, rat for LIMS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LIMS2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4