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Aliases for LIMS2 Gene

Aliases for LIMS2 Gene

  • LIM And Senescent Cell Antigen-Like Domains 2 2 3
  • Particularly Interesting New Cys-His Protein 2 3 4
  • LIM-Like Protein 2 3 4
  • PINCH-2 3 4
  • PINCH2 3 4
  • LIM And Senescent Cell Antigen-Like-Containing Domain Protein 2 3
  • ILK-Binding Protein 3

External Ids for LIMS2 Gene

Summaries for LIMS2 Gene

Entrez Gene Summary for LIMS2 Gene

  • This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for LIMS2 Gene

LIMS2 (LIM And Senescent Cell Antigen-Like Domains 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for LIMS2 Gene

  • Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMS2 Gene

Genomics for LIMS2 Gene

Genomic Location for LIMS2 Gene

Start:
127,638,381 bp from pter
End:
127,681,786 bp from pter
Size:
43,406 bases
Orientation:
Minus strand

Genomic View for LIMS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMS2 Gene

Regulatory Elements for LIMS2 Gene

Proteins for LIMS2 Gene

  • Protein details for LIMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4I7-LIMS2_HUMAN
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 2
    Protein Accession:
    Q7Z4I7
    Secondary Accessions:
    • A6NLH0
    • B4DMV1
    • F5H6E6
    • Q7Z4I2
    • Q7Z4I6
    • Q7Z4I8
    • Q8NFE7
    • Q9HA13

    Protein attributes for LIMS2 Gene

    Size:
    341 amino acids
    Molecular mass:
    38916 Da
    Quaternary structure:
    • Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
    SequenceCaution:
    • Sequence=AAM77350.1; Type=Frameshift; Positions=331; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIMS2 Gene

    Alternative splice isoforms for LIMS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMS2 Gene

Proteomics data for LIMS2 Gene at MOPED

Post-translational modifications for LIMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LIMS2 Gene

Domains for LIMS2 Gene

Protein Domains for LIMS2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

LIMS2_HUMAN
Domain:
  • Contains 5 LIM zinc-binding domains.:
    • Q7Z4I7
genes like me logo Genes that share domains with LIMS2: view

No data available for Gene Families for LIMS2 Gene

Function for LIMS2 Gene

Molecular function for LIMS2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.

Gene Ontology (GO) - Molecular Function for LIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LIMS2: view
genes like me logo Genes that share phenotypes with LIMS2: view

Animal Models for LIMS2 Gene

MGI Knock Outs for LIMS2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LIMS2 Gene

Localization for LIMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMS2 Gene

Nucleus. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIMS2 Gene COMPARTMENTS Subcellular localization image for LIMS2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for LIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with LIMS2: view

Pathways for LIMS2 Gene

genes like me logo Genes that share pathways with LIMS2: view

Pathways by source for LIMS2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for LIMS2 Gene
1 Qiagen pathway for LIMS2 Gene

Gene Ontology (GO) - Biological Process for LIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0034329 cell junction assembly TAS --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045216 cell-cell junction organization IEA --
GO:0050680 negative regulation of epithelial cell proliferation --
genes like me logo Genes that share ontologies with LIMS2: view

Transcripts for LIMS2 Gene

Unigene Clusters for LIMS2 Gene

LIM and senescent cell antigen-like domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIMS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - -
SP13: -
SP14: - - - -
SP15:
SP16:
SP17: -

ExUns: 14c ^ 15a · 15b ^ 16a · 16b · 16c · 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - -
SP16:
SP17:

Relevant External Links for LIMS2 Gene

GeneLoc Exon Structure for
LIMS2
ECgene alternative splicing isoforms for
LIMS2

Expression for LIMS2 Gene

mRNA expression in normal human tissues for LIMS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIMS2 Gene

This gene is overexpressed in Colon - Sigmoid (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIMS2 Gene

SOURCE GeneReport for Unigene cluster for LIMS2 Gene Hs.469881

genes like me logo Genes that share expressions with LIMS2: view

Orthologs for LIMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIMS2 36
  • 99.5 (n)
  • 99.7 (a)
LIMS2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIMS2 36
  • 91.57 (n)
  • 95.24 (a)
LIMS2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIMS2 36
  • 91.77 (n)
  • 96.13 (a)
LIMS2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lims2 36
  • 88.76 (n)
  • 91.34 (a)
Lims2 16
Lims2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LIMS2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIMS2 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lims2 36
  • 87.73 (n)
  • 90.71 (a)
chicken
(Gallus gallus)
Aves LIMS2 36
  • 83.53 (n)
  • 93.75 (a)
LIMS2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIMS2 37
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stck 37
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-97 37
  • 58 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11312 37
  • 63 (a)
OneToMany
Species with no ortholog for LIMS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for LIMS2 Gene

ENSEMBL:
Gene Tree for LIMS2 (if available)
TreeFam:
Gene Tree for LIMS2 (if available)

Paralogs for LIMS2 Gene

Paralogs for LIMS2 Gene

Pseudogenes.org Pseudogenes for LIMS2 Gene

genes like me logo Genes that share paralogs with LIMS2: view

Variants for LIMS2 Gene

Sequence variations from dbSNP and Humsavar for LIMS2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs15235 -- 127,638,712(+) TGGGT(G/T)TGGAC utr-variant-3-prime, nc-transcript-variant
rs891515 -- 127,639,232(+) ACAGC(A/G)GGAGG utr-variant-3-prime, nc-transcript-variant
rs1055139 -- 127,638,699(-) AGCTA(A/C)CTGGA utr-variant-3-prime, nc-transcript-variant
rs1055173 -- 127,638,533(-) GGTCA(A/G)AGGTG utr-variant-3-prime, nc-transcript-variant
rs1055199 -- 127,638,484(-) CCAGC(C/G)CAGAC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LIMS2 Gene

Variant ID Type Subtype PubMed ID
nsv875015 CNV Loss 21882294
dgv4298n71 CNV Loss 21882294
dgv4299n71 CNV Loss 21882294
nsv518085 CNV Loss 19592680
nsv508864 CNV Insertion 20534489
nsv470482 CNV Loss 18288195
dgv4300n71 CNV Loss 21882294
nsv875026 CNV Loss 21882294
nsv517532 CNV Loss 19592680
nsv875027 CNV Loss 21882294
nsv875028 CNV Gain 21882294
dgv4301n71 CNV Loss 21882294
nsv875030 CNV Loss 21882294
nsv875031 CNV Loss 21882294
nsv875033 CNV Loss 21882294

Relevant External Links for LIMS2 Gene

HapMap Linkage Disequilibrium report
LIMS2

Disorders for LIMS2 Gene

Relevant External Links for LIMS2

Human Genome Epidemiology (HuGE) Navigator
LIMS2
genes like me logo Genes that share disorders with LIMS2: view

No data available for UniProtKB/Swiss-Prot for LIMS2 Gene

Publications for LIMS2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PMID: 12167643) Zhang Y. … Wu C. (J. Biol. Chem. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for LIMS2 Gene

Sources for LIMS2 Gene

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