Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LIMS1 Gene

protein-coding   GIFtS: 61
GCID: GC02P109150

LIM And Senescent Cell Antigen-Like Domains 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LIM And Senescent Cell Antigen-Like Domains 11 2     PINCH-12 3
Particularly Interesting New Cys-His Protein 12 3     PINCH12 3
Renal Carcinoma Antigen NY-REN-482 3     LIM And Senescent Cell Antigen-Like-Containing Domain Protein 12
PINCH2 3     

External Ids:    HGNC: 66161   Entrez Gene: 39872   Ensembl: ENSG000001697567   OMIM: 6025675   UniProtKB: P480593   

Export aliases for LIMS1 gene to outside databases

Previous GC identifers: GC02P107110 GC02P107684 GC02P108755 GC02P108772 GC02P108826 GC02P108609


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LIMS1 Gene:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers.
The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with
integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking
integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling
pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in
integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for LIMS1 Gene:
LIMS1 (LIM and senescent cell antigen-like domains 1) is a protein-coding gene. Diseases associated with LIMS1 include ebstein anomaly, and atrioventricular septal defect. An important paralog of this gene is PDLIM7.

UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell
survival, cell proliferation and cell differentiation

Gene Wiki entry for LIMS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIMS1 gene promoter:
         Bach1   POU2F1   POU2F1a   POU2F1b   Nkx2-2   Brachyury   FOXJ2 (long isoform)   POU2F1c   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIMS1 promoter sequence
   Search Chromatin IP Primers for LIMS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIMS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

LIMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P109150:  view genomic region     (about GC identifiers)

Start:
109,150,811 bp from pter      End:
109,303,702 bp from pter
Size:
152,892 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059 (See protein sequence)
Recommended Name: LIM and senescent cell antigen-like-containing domain protein 1  
Size: 325 amino acids; 37251 Da
Subunit: Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein
kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex
composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby
linking the complex to cell surface receptors
Selected PDB 3D structures from and Proteopedia for LIMS1 (see all 9):
1G47 (3D)        1NYP (3D)        1U5S (3D)        2COR (3D)        2D8X (3D)        2KBX (3D)    
Secondary accessions: B2RAJ4 B7Z483 B7Z7R3 B7Z907 Q53TE0 Q9BS44
Alternative splicing: 5 isoforms:  P48059-1   P48059-2   P48059-3   P48059-4   P48059-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIMS1: NX_P48059

Explore proteomics data for LIMS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LIMS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001180411.1  NP_001180412.1  NP_001180413.1  NP_001180414.1  NP_001180417.1  NP_004978.2  

    ENSEMBL proteins: 
     ENSP00000390862   ENSP00000331775   ENSP00000376987   ENSP00000386926   ENSP00000387264  
     ENSP00000402322   ENSP00000337598   ENSP00000399267   ENSP00000410751   ENSP00000437912  
     ENSP00000446121   ENSP00000376990  
    Reactome Protein details: P48059

    LIMS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LIMS1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LIMS1
    GenScript Custom Purified and Recombinant Proteins Services for LIMS1
    Novus Biologicals LIMS1 Proteins
    Novus Biologicals LIMS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIMS1

    LIMS1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LIMS1
    R&D Systems Antibodies for LIMS1 (PINCH1)
    Cell Signaling Technology (CST) Antibodies for LIMS1 
    OriGene Antibodies for LIMS1
    OriGene Custom Antibody Services for LIMS1
    Novus Biologicals LIMS1 Antibodies
    Search for Antibodies for LIMS1 at Abcam
    Cloud-Clone Corp. Antibodies for LIMS1
    ThermoFisher Antibody for LIMS1
    LSBio Antibodies in human, mouse, rat for LIMS1

    LIMS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LIMS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LIMS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIMS1
    Cloud-Clone Corp. CLIAs for LIMS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR017351 PINCH
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P48059

    ProtoNet protein and cluster: P48059

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
    Similarity: Contains 5 LIM zinc-binding domains


    LIMS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMS1_HUMAN, P48059
    Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
    complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell
    survival, cell proliferation and cell differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10574708
    GO:0008270zinc ion binding IDA19074270
         
    LIMS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LIMS1:
     Weaker migration 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lims1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  normal  respiratory system 

    LIMS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LIMS1: Lims1tm2Ref Lims1tm1.2Chen Lims1tm1Ref

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIMS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIMS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIMS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIMS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LIMS1:
    hsa-mir-421 (MIRT016105), hsa-mir-18a-3p (MIRT040780), hsa-mir-1 (MIRT023868), hsa-mir-590-3p (MIRT016188), hsa-mir-505-3p (MIRT041021), hsa-mir-744-5p (MIRT037466), hsa-mir-221-3p (MIRT024188), hsa-mir-215-5p (MIRT024835), hsa-mir-192-5p (MIRT026671), hsa-mir-340-5p (MIRT019634), hsa-mir-1226-3p (MIRT036467)

    Block miRNA regulation of human, mouse, rat LIMS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIMS1 (see all 77):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-548j hsa-miR-26a-2* hsa-miR-607 hsa-miR-15a hsa-miR-759 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidLIMS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LIMS1
    Predesigned siRNA for gene silencing in human, mouse, rat LIMS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LIMS1

    Clone
    Products:
         
    OriGene clones in human, mouse for LIMS1 (see all 19)
    OriGene ORF clones in mouse, rat for LIMS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): LIMS1 (NM_004987)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LIMS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LIMS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LIMS1_HUMAN, P48059: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005925colocalizes with focal adhesion IDA19117955
    GO:0048471perinuclear region of cytoplasm IDA--

    LIMS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LIMS1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.00
    Cell-Cell communication0.64
    Cell-extracellular matrix interactions0.00
    2ERK Signaling
    ILK Signaling0.49
    3Cell adhesion Integrin mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside in signaling0.37
    4EphB-EphrinB Signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    5Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LIMS1
        ILK Signaling

    2 Cell Signaling Technology (CST) Pathways for LIMS1
        Cytoskeletal Signaling
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for LIMS1
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    2 Reactome Pathways for LIMS1
        Cell-extracellular matrix interactions
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components



    LIMS1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIMS1
    Interactions:

        GeneGlobe Interaction Network for LIMS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LIMS1 (P480591, 2, 3 ENSP000003317754) via UniProtKB, MINT, STRING, and/or I2D (see all 810)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, 2, 3, ENSP000002994214EBI-306928,EBI-747644 MINT-7945693 I2D: score=6 STRING: ENSP00000299421
    NCK2O436391, 2, 3, ENSP000002331544EBI-306928,EBI-713635 MINT-7303218 I2D: score=5 STRING: ENSP00000233154
    EHMT2Q96KQ72, 3, ENSP000003646874MINT-67171 I2D: score=5 STRING: ENSP00000364687
    ENSG00000206376Q96KQ72, 3MINT-67171 I2D: score=5 
    ENSG00000232045Q96KQ72, 3MINT-67171 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007569cell aging TAS7517666
    GO:0034329cell junction assembly TAS--
    GO:0045892negative regulation of transcription, DNA-templated IDA--
    GO:0071560cellular response to transforming growth factor beta stimulus IEP--

    LIMS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIMS1

    2 Novoseek inferred chemical compound relationships for LIMS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 25.1 1 12216108 (1)
    serine 22.5 2 17656471 (1), 17897939 (1)



    LIMS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LIMS1 gene (6 alternative transcripts): 
    NM_001193482.1  NM_001193483.2  NM_001193484.1  NM_001193485.2  NM_001193488.1  NM_004987.5  

    Unigene Clusters for LIMS1:

    LIM and senescent cell antigen-like domains 1
    Hs.597715  [show with all ESTs], Hs.613268  [show with all ESTs]
    Unigene Representative Sequences: NM_001193485, AK098109
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428064 ENST00000332345 ENST00000393310(uc002tel.3 uc002teg.3 uc002teh.3 uc002tei.3 uc002tej.3 uc002tek.4)
    ENST00000410093 ENST00000449684 ENST00000409441 ENST00000422797 ENST00000338045
    ENST00000474038 ENST00000462817 ENST00000496653 ENST00000414829 ENST00000434274
    ENST00000480744 ENST00000544547 ENST00000542845 ENST00000393314
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LIMS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIMS1 (see all 77):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-548j hsa-miR-26a-2* hsa-miR-607 hsa-miR-15a hsa-miR-759 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidLIMS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LIMS1
    Predesigned siRNA for gene silencing in human, mouse, rat LIMS1
    Clone
    Products:
         
    OriGene clones in human, mouse for LIMS1 (see all 19)
    OriGene ORF clones in mouse, rat for LIMS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): LIMS1 (NM_004987)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LIMS1
    OriGene qSTAR qPCR primer pairs in human, mouse for LIMS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIMS1
      QuantiTect SYBR Green Assays in human, mouse, rat LIMS1
      QuantiFast Probe-based Assays in human, mouse, rat LIMS1

    Additional mRNA sequence: AK098109.1 

    21 DOTS entries:

    DT.314499  DT.100816051  DT.91853356  DT.314500  DT.310285  DT.91754542  DT.97847228  DT.91715366 
    DT.99935620  DT.100816049  DT.121007506  DT.87014405  DT.121007578  DT.121007627  DT.99929181  DT.100816045 
    DT.121007554  DT.121031905  DT.86842551  DT.91712046  DT.91754536 

    Selected AceView cDNA sequences (see all 278):

    BM913110 CB132160 BM471041 AI865286 BP340796 AW029206 AI160042 CA440514 
    N54128 AI633479 BF591303 AW515425 AA342958 AF527761 CR591172 AI471034 
    BU948121 BM751907 CA396283 BM905025 AI469624 AA877432 AA629604 AA970374 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LIMS1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                    -     -     -     -           -                                                   
    SP2:        -     -     -     -     -     -     -     -     -           -     -     -     -           -                                                   
    SP3:              -     -     -     -     -     -     -     -           -     -     -     -           -                                                   
    SP4:                          -     -     -     -     -     -           -     -     -     -           -                                                   
    SP5:                                -     -     -     -     -           -     -     -     -           -                                                   


    ECgene alternative splicing isoforms for LIMS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LIMS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAATTCT
    LIMS1 Expression
    About this image


    LIMS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             Mesonephric cells Mesonephros
     
     Neural Tube (Nervous System)
             Telencephalon
    LIMS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIMS1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.597715 Hs.613268

    UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
    Tissue specificity: Expressed in most tissues except in the brain

        Custom PCR Arrays for LIMS1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LIMS1
    OriGene qSTAR qPCR primer pairs in human, mouse for LIMS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIMS1
    QuantiTect SYBR Green Assays in human, mouse, rat LIMS1
    QuantiFast Probe-based Assays in human, mouse, rat LIMS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LIMS1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lims11 , 5 LIM and senescent cell antigen-like domains 11, 5 90.72(n)1
    99.39(a)1
      10 (29.31 cM)5
    1108291  NM_201242.11  NP_957694.11 
     583234665 
    chicken
    (Gallus gallus)
    Aves LIMS11 LIM and senescent cell antigen-like domains 1 82.87(n)
    96.31(a)
      414880  NM_001001766.1  NP_001001766.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    92(a)
    1 → many
    3(107508842-107530508)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126052 Xenopus laevis transcribed sequence with strong similarity more 80.9(n)    CA981315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc32c032 Transcribed sequence with strong similarity to protein more 79.36(n)    57048798 
    fruit fly
    (Drosophila melanogaster)
    Insecta stck1 , 3 steamer duck1 65(a)3
    65.2(n)1
    67.92(a)1
      3 84F153
    409991  NM_169221.21  NP_731242.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-971 , 3 LIM domain containing protein3
    unc-971
    61(a)3
    63.03(n)1
    60.58(a)1
      X(5628432-5629784)3
    1808271  NM_076542.51  NP_508943.31 


    ENSEMBL Gene Tree for LIMS1 (if available)
    TreeFam Gene Tree for LIMS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LIMS1 gene
    PDLIM72  LIMS3L2  FHL32  FHL52  LDB32  LPXN2  FHL12  ENSG000002572072  
    LIMS32  TGFB1I12  PDLIM52  PXN2  LIMS22  FHL22  
    Selected SIMAP similar genes for LIMS1 using alignment to 7 protein entries:     LIMS1_HUMAN (see all proteins) (see all similar genes):
    LIMS3    LIMS3L    LIMS2    ABLIM3    LPP    LIMD1
    PDLIM5    TRIP6    TRIP6i1    ZYX    CRIP1    LHX3
    LHX4    LIMK1    PRICKLE3    PXN    ABLIM2    ABLIM1

    LIMS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LIMS1 (see all 2997)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666517521,2
    C--108933991(+) AAAAA-/AAAATAT/A
    AATATA
    /TATAT
    TATAT
    5 -- int11NA 2
    rs1167437681,2
    F--109148831(+) TAGTTG/AAAGTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1807783341,2
    --109148924(+) ACAATA/GTATAG 1 -- us2k10--------
    rs1406226711,2
    C--109148972(+) TTTAT-/TTTTG 
            
    TTTTA
    1 -- us2k10--------
    rs675581031,2
    C--109148976(+) TTTAT-/TTTTG 
            
    TTTTA
    1 -- us2k10--------
    rs2016478941,2
    C--109148976(+) TTTTTA/G/TTTTTA 1 -- us2k10--------
    rs1850560671,2
    --109149341(+) AACCCC/TGCCAC 1 -- us2k10--------
    rs1893348981,2
    C--109149342(+) ACCCCA/GCCACC 1 -- us2k10--------
    rs1128748061,2
    F--109149368(+) TTTGTG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs25776271,2
    C,F,A--109149375(-) CTCTAC/ATAAAA 1 -- us2k17Minor allele frequency- A:0.42NA WA CSA 12

    HapMap Linkage Disequilibrium report for LIMS1 (109150811 - 109303702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LIMS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720498CNV Deletion23290073
    nsv521122CNV Loss19592680
    nsv527491CNV Loss19592680
    nsv834328CNV Gain17160897
    dgv153e55CNV Gain17911159
    dgv1234e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIMS1
    DNA2.0 Custom Variant and Variant Library Synthesis for LIMS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602567    OMIM disorders: --

    Selected diseases for LIMS1 (see all 22):    
    About MalaCards
    ebstein anomaly    atrioventricular septal defect    pancreatic ductal adenocarcinoma    b-cell chronic lymphocytic leukemia
    chronic lymphocytic leukemia    dilated cardiomyopathy    gastric adenocarcinoma    squamous cell carcinoma
    endometrial carcinoma    oral squamous cell carcinoma    esophageal squamous cell carcinoma    colorectal cancer
    acute myeloid leukemia    adenocarcinoma    renal cell carcinoma    myeloid leukemia
    leukemia    esophagitis    pancreatitis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for LIMS1:
    Ebstein anomaly     Atrioventricular septal defect

    LIMS1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for LIMS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 25.1 8 16482633 (3), 15720806 (2), 17026740 (1), 16273248 (1)
    carcinoma squamous cell 23.8 9 18957717 (4), 16273248 (2)
    colorectal carcinoma 19.1 1 17026740 (1)
    metastasis 9.38 14 16273248 (3), 18957717 (2), 15720806 (1), 17805569 (1)
    adenocarcinoma 4.56 1 16482633 (1)
    tumors 0 19 18957717 (4), 15720806 (3), 18187956 (2), 18436335 (1)
    cancer 0 4 16314921 (1), 18187956 (1), 15720806 (1), 18957717 (1)


    Export disorders for LIMS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LIMS1 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with LIMS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (PubMed id 10022929)1, 2, 3 Tu Y.... Wu C. (Mol. Cell. Biol. 1999)
    2. A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'. (PubMed id 7517666)1, 2, 3 Rearden A. (Biochem. Biophys. Res. Commun. 1994)
    3. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PubMed id 19117955)1, 2, 9 Yang Y.... Qin J. (J. Biol. Chem. 2009)
    4. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. (PubMed id 9843575)1, 2, 9 Tu Y.... Wu C. (Mol. Biol. Cell 1998)
    5. Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. (PubMed id 12794636)1, 2, 9 Velyvis A....Qin J. (Nat. Struct. Biol. 2003)
    6. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. (PubMed id 11078733)1, 2, 9 Velyvis A.... Qin J. (J. Biol. Chem. 2001)
    7. The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)1, 2, 9 Chiswell B.P.... Calderwood D.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3987 HGNC: 6616 AceView: LIMS1 Ensembl:ENSG00000169756 euGenes: HUgn3987
    ECgene: LIMS1 H-InvDB: LIMS1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LIMS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LIMS1 gene:
    Search GeneIP for patents involving LIMS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LIMS1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for LIMS1 (PINCH1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LIMS1   OriGene RNAi products in human, mouse, rat for LIMS1  
     OriGene qPCR primer pairs and template standards for LIMS1   OriGene Protein Over-expression Lysate for LIMS1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LIMS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LIMS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LIMS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LIMS1   OriGene Custom Protein Services for LIMS1  

     
     
     Block miRNA regulation of human, mouse, rat LIMS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LIMS1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIMS1 Predesigned siRNA for gene silencing in human, mouse, rat LIMS1
     QuantiFast Probe-based Assays in human, mouse, rat LIMS1 QuantiTect SYBR Green Assays in human, mouse, rat LIMS1
     Custom PCR Arrays for LIMS1 Search Chromatin IP Primers for LIMS1
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LIMS1  GeneGlobe Interaction Network for LIMS1
     Regulatory tfbs in LIMS1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LIMS1 GenScript cDNA clones with any tag delivered in your preferred vector for LIMS1
     GenScript Custom Assay Services for LIMS1 GenScript Custom overexpressing Cell Line Services for LIMS1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for LIMS1 

     Search Tocris compounds for LIMS1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LIMS1 antibodies
     LIMS1 proteins
     LIMS1 lysates
     Search for Antibodies for LIMS1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LIMS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LIMS1
     Antibodies for LIMS1
     ELISAs for LIMS1
     CLIAs for LIMS1



     Browse ESI BIO Cell Lines and PureStem Progenitors for LIMS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS1
     SwitchGear 3'UTR luciferase reporter plasmids for LIMS1
     SwitchGear Promoter luciferase reporter plasmids for LIMS1
     ThermoFisher Antibody for LIMS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIMS1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIMS1
     LSBio Antibodies in human, mouse, rat for LIMS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LIMS1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4