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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIMS1 Gene

protein-coding   GIFtS: 62
GCID: GC02P109150

LIM And Senescent Cell Antigen-Like Domains 1

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM And Senescent Cell Antigen-Like Domains 11 2     PINCH-12 3
Particularly Interesting New Cys-His Protein 12 3     PINCH12 3
Renal Carcinoma Antigen NY-REN-482 3     LIM And Senescent Cell Antigen-Like-Containing Domain Protein 12
PINCH2 3     

External Ids:    HGNC: 66161   Entrez Gene: 39872   Ensembl: ENSG000001697567   OMIM: 6025675   UniProtKB: P480593   

Export aliases for LIMS1 gene to outside databases

Previous GC identifers: GC02P107110 GC02P107684 GC02P108755 GC02P108772 GC02P108826 GC02P108609


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIMS1 Gene:
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers.
The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with
integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking
integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling
pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in
integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for LIMS1 Gene: 
LIMS1 (LIM and senescent cell antigen-like domains 1) is a protein-coding gene. Diseases associated with LIMS1 include ebstein anomaly, and double outlet right ventricle, and among its related super-pathways are Cell-cell junction organization and Cell-extracellular matrix interactions. GO annotations related to this gene include protein binding and zinc ion binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell
survival, cell proliferation and cell differentiation

Gene Wiki entry for LIMS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIMS1 gene promoter:
         Bach1   POU2F1   POU2F1a   POU2F1b   Nkx2-2   Brachyury   FOXJ2 (long isoform)   POU2F1c   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIMS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LIMS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3   Ensembl cytogenetic band:  2q12.3   HGNC cytogenetic band: 2q12.3

LIMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P109150:  view genomic region     (about GC identifiers)

Start:
109,150,811 bp from pter      End:
109,303,702 bp from pter
Size:
152,892 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059 (See protein sequence)
Recommended Name: LIM and senescent cell antigen-like-containing domain protein 1  
Size: 325 amino acids; 37251 Da
Subunit: Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein
kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex
composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby
linking the complex to cell surface receptors
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side
6/7 PDB 3D structures from and Proteopedia for LIMS1 (see all 7):
1G47 (3D)        1NYP (3D)        1U5S (3D)        2COR (3D)        2D8X (3D)        2KBX (3D)    
Secondary accessions: B2RAJ4 B7Z483 B7Z7R3 B7Z907 Q53TE0 Q9BS44
Alternative splicing: 5 isoforms:  P48059-1   P48059-2   P48059-3   P48059-4   P48059-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIMS1: NX_P48059

Explore proteomics data for LIMS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48059

  • LIMS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIMS1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001180411.1  NP_001180412.1  NP_001180413.1  NP_001180414.1  NP_001180417.1  NP_004978.2  

    ENSEMBL proteins: 
     ENSP00000390862   ENSP00000331775   ENSP00000376987   ENSP00000386926   ENSP00000387264  
     ENSP00000402322   ENSP00000337598   ENSP00000399267   ENSP00000410751   ENSP00000437912  
     ENSP00000446121   ENSP00000376990  
    Reactome Protein details: P48059
    Human Recombinant Protein Products for LIMS1: 
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    Novus Biologicals LIMS1 Proteins
    Novus Biologicals LIMS1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIMS1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0005925colocalizes with focal adhesion IDA19117955
    GO:0048471perinuclear region of cytoplasm IDA--

    LIMS1 for ontologies           About GeneDecksing



    LIMS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LIMS1
    R&D Systems Antibodies for LIMS1 (PINCH1)
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    Abcam antibodies for LIMS1
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    ThermoFisher Antibody for LIMS1
    LSBio Antibodies in human, mouse, rat for LIMS1 

    Assay Products for LIMS1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LIMS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIMS1 
    Cloud-Clone Corp. CLIAs for LIMS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017351 PINCH
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P48059

    ProtoNet protein and cluster: P48059

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
    Similarity: Contains 5 LIM zinc-binding domains


    LIMS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMS1_HUMAN, P48059
    Function: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the
    complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell
    survival, cell proliferation and cell differentiation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10574708
    GO:0008270zinc ion binding IDA19074270
         
    LIMS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LIMS1:
     Weaker migration 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Lims1):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  normal  respiratory system 

    LIMS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LIMS1: Lims1tm2Ref Lims1tm1.2Chen Lims1tm1Ref

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIMS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIMS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIMS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIMS1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIMS1
    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMS1 (see all 77):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-548j hsa-miR-26a-2* hsa-miR-607 hsa-miR-15a hsa-miR-759 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidLIMS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): LIMS1 (NM_004987)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMS1
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                         Customized lentivirus expression plasmids for stable overexpression of LIMS1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LIMS1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell junction organization0.69
    Cell-Cell communication0.64
    2Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components0.44
    Cell-extracellular matrix interactions0.44
    3Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    4Rho Family GTPases
    ILK Signaling0.49
    5Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for LIMS1
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LIMS1
        ILK Signaling

    2 Cell Signaling Technology (CST) Pathways for LIMS1
        Cytoskeletal Signaling
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for LIMS1
        Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    4        Reactome Pathways for LIMS1
        Cell-extracellular matrix interactions
    Cell junction organization
    Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
    Cell-Cell communication



    LIMS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIMS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/805 Interacting proteins for LIMS1 (P480591, 2, 3 ENSP000003317754) via UniProtKB, MINT, STRING, and/or I2D (see all 805)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, 2, 3, ENSP000002994214EBI-306928,EBI-747644 MINT-7945693 I2D: score=6 STRING: ENSP00000299421
    EHMT2Q96KQ72, 3, ENSP000003646874MINT-67171 I2D: score=5 STRING: ENSP00000364687
    ENSG00000206376Q96KQ72, 3MINT-67171 I2D: score=5 
    ENSG00000232045Q96KQ72, 3MINT-67171 I2D: score=5 
    ENSG00000236759Q96KQ72, 3MINT-67171 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007569cell aging TAS7517666
    GO:0034329cell junction assembly TAS--
    GO:0045892negative regulation of transcription, DNA-dependent IDA--
    GO:0071560cellular response to transforming growth factor beta stimulus IEP--

    LIMS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LIMS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIMS1

    2 Novoseek inferred chemical compound relationships for LIMS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 25.1 1 12216108 (1)
    serine 22.5 2 17656471 (1), 17897939 (1)

    Search CenterWatch for drugs/clinical trials and news about LIMS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIMS1 gene (6 alternative transcripts): 
    NM_001193482.1  NM_001193483.2  NM_001193484.1  NM_001193485.2  NM_001193488.1  NM_004987.5  

    Unigene Clusters for LIMS1:

    LIM and senescent cell antigen-like domains 1
    Hs.597715  [show with all ESTs], Hs.613268  [show with all ESTs]
    Unigene Representative Sequences: NM_001193485, AK098109
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428064 ENST00000332345 ENST00000393310(uc002tel.3 uc002teg.3 uc002teh.3 uc002tei.3 uc002tej.3 uc002tek.4)
    ENST00000410093 ENST00000449684 ENST00000409441 ENST00000422797 ENST00000338045
    ENST00000474038 ENST00000462817 ENST00000496653 ENST00000414829 ENST00000434274
    ENST00000480744 ENST00000544547 ENST00000542845 ENST00000393314

    miRNA
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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMS1 (see all 77):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-548j hsa-miR-26a-2* hsa-miR-607 hsa-miR-15a hsa-miR-759 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidLIMS1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMS1

    Additional mRNA sequence: AK098109.1 

    21 DOTS entries:

    DT.314499  DT.100816051  DT.91853356  DT.314500  DT.310285  DT.91754542  DT.97847228  DT.91715366 
    DT.99935620  DT.100816049  DT.121007506  DT.87014405  DT.121007578  DT.121007627  DT.99929181  DT.100816045 
    DT.121007554  DT.121031905  DT.86842551  DT.91712046  DT.91754536 

    24/278 AceView cDNA sequences (see all 278):

    AA970374 U09284 AA988549 AA732465 AU132995 AF527761 AI828710 BP340796 
    BF591303 BM915370 AI087194 AI160042 N54128 CR591172 CD368504 BQ214424 
    BU948121 BQ216893 AI633479 AA877432 AI471034 NM_004987 BF438476 AW243960 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LIMS1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                    -     -     -     -           -                                                   
    SP2:        -     -     -     -     -     -     -     -     -           -     -     -     -           -                                                   
    SP3:              -     -     -     -     -     -     -     -           -     -     -     -           -                                                   
    SP4:                          -     -     -     -     -     -           -     -     -     -           -                                                   
    SP5:                                -     -     -     -     -           -     -     -     -           -                                                   


    ECgene alternative splicing isoforms for LIMS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIMS1 expression in normal human tissues (normalized intensities)      LIMS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAATTCT
    LIMS1 Expression
    About this image


    LIMS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             BONE MARROW   
     
     Liver (Hepatobiliary System)
             visceral organ   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See LIMS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIMS1

    SOURCE GeneReport for Unigene clusters: Hs.597715 Hs.613268

    UniProtKB/Swiss-Prot: LIMS1_HUMAN, P48059
    Tissue specificity: Expressed in most tissues except in the brain

        SABiosciences Custom PCR Arrays for LIMS1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIMS1 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lims11 , 5 LIM and senescent cell antigen-like domains 11, 5 89.78(n)1
    97.79(a)1
      10 (29.31 cM)5
    1108291  NM_201242.11  NP_957694.11 
     583234665 
    chicken
    (Gallus gallus)
    Aves LIMS11 LIM and senescent cell antigen-like domains 1 82.87(n)
    96.31(a)
      414880  NM_001001766.1  NP_001001766.1 
    lizard
    (Anolis carolinensis)
    Reptilia LIMS16
    Uncharacterized protein
    92(a)
    1 → many
    3(107508842-107530508)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126052 Xenopus laevis transcribed sequence with strong similarity more 80.9(n)    CA981315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc32c032 Transcribed sequence with strong similarity to protein more 79.36(n)    57048798 
    fruit fly
    (Drosophila melanogaster)
    Insecta stck1 , 3 steamer duck1 65(a)3
    63.36(n)1
    65.77(a)1
      3 84F153
    409991  NM_169220.21  NP_731241.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-971 , 3 LIM domain containing protein3
    Protein UNC-971
    61(a)3
    62.58(n)1
    61.01(a)1
      X(5628432-5629784)3
    1808271  NM_076542.41  NP_508943.31 


    ENSEMBL Gene Tree for LIMS1 (if available)
    TreeFam Gene Tree for LIMS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIMS1 gene
    ABLIM32  LIMS3L2  DMTN2  LDB32  FHL52  LPXN2  PDLIM52  ENSG000002572072  
    ABLIM22  LIMS22  FHL22  ABLIM12  PDLIM72  FHL32  FHL12  LIMS32  
    TGFB1I12  PXN2  
    18/22 SIMAP similar genes for LIMS1 using alignment to 7 protein entries:     LIMS1_HUMAN (see all proteins) (see all similar genes):
    LIMS3L    LIMS3    LIMS2    ABLIM3    LPP    LIMD1
    PDLIM5    TRIP6    TRIP6i1    ZYX    CRIP1    LHX3
    LHX4    LIMK1    PRICKLE3    ABLIM1    PXN    ABLIM2

    LIMS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2997 SNPs in LIMS1 are shown (see all 2997)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs666517521,2
    C--108933991(+) AAAAA-/AAAATAT/A
    AATATA
    /TATAT
    TATAT
    5 -- int11NA 2
    rs1167437681,2
    F--109148831(+) TAGTTG/AAAGTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1807783341,2
    --109148924(+) ACAATA/GTATAG 1 -- us2k10--------
    rs1406226711,2
    C--109148972(+) TTTAT-/TTTTG 
            
    TTTTA
    1 -- us2k10--------
    rs675581031,2
    C--109148976(+) TTTAT-/TTTTG 
            
    TTTTA
    1 -- us2k10--------
    rs2016478941,2
    C--109148976(+) TTTTTA/G/TTTTTA 1 -- us2k10--------
    rs1850560671,2
    --109149341(+) AACCCC/TGCCAC 1 -- us2k10--------
    rs1893348981,2
    C--109149342(+) ACCCCA/GCCACC 1 -- us2k10--------
    rs1128748061,2
    F--109149368(+) TTTGTG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs25776271,2
    C,F,A--109149375(-) CTCTAC/ATAAAA 1 -- us2k17Minor allele frequency- A:0.42NA WA CSA 12

    HapMap Linkage Disequilibrium report for LIMS1 (109150811 - 109303702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LIMS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720498CNV Deletion23290073
    nsv521122CNV Loss19592680
    nsv527491CNV Loss19592680
    nsv834328CNV Gain17160897
    dgv153e55CNV Gain17911159
    dgv1234e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602567    OMIM disorders: --

    20/21 diseases for LIMS1 (see all 21):    About MalaCards
    ebstein anomaly    double outlet right ventricle    atrioventricular septal defect    pancreatic ductal adenocarcinoma
    b-cell chronic lymphocytic leukemia    dilated cardiomyopathy    squamous cell carcinoma    oral squamous cell carcinoma
    endometrial carcinoma    esophageal squamous cell carcinoma    colorectal cancer    acute myeloid leukemia
    adenocarcinoma    chronic lymphocytic leukemia    esophagitis    myeloid leukemia
    renal cell carcinoma    leukemia    pancreatitis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for LIMS1:
    Ebstein anomaly     Atrioventricular septal defect

    LIMS1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for LIMS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 25.1 8 16482633 (3), 15720806 (2), 17026740 (1), 16273248 (1)
    carcinoma squamous cell 23.8 9 18957717 (4), 16273248 (2)
    colorectal carcinoma 19.1 1 17026740 (1)
    metastasis 9.38 14 16273248 (3), 18957717 (2), 15720806 (1), 17805569 (1)
    adenocarcinoma 4.56 1 16482633 (1)
    tumors 0 19 18957717 (4), 15720806 (3), 18187956 (2), 18436335 (1)
    cancer 0 4 16314921 (1), 18187956 (1), 15720806 (1), 18957717 (1)


    Export disorders for LIMS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIMS1 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with LIMS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (PubMed id 10022929)1, 2, 3 Tu Y.... Wu C. (1999)
    2. A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'. (PubMed id 7517666)1, 2, 3 Rearden A. (1994)
    3. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PubMed id 19117955)1, 2, 9 Yang Y.... Qin J. (2009)
    4. Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. (PubMed id 9843575)1, 2, 9 Tu Y.... Wu C. (1998)
    5. Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. (PubMed id 12794636)1, 2, 9 Velyvis A....Qin J. (2003)
    6. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. (PubMed id 11078733)1, 2, 9 Velyvis A.... Qin J. (2001)
    7. The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)1, 2, 9 Chiswell B.P.... Calderwood D.A. (2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3987 HGNC: 6616 AceView: LIMS1 Ensembl:ENSG00000169756 euGenes: HUgn3987
    ECgene: LIMS1 H-InvDB: LIMS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIMS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIMS1 gene:
    Search GeneIP for patents involving LIMS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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