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Aliases for LIMS1 Gene

Aliases for LIMS1 Gene

  • LIM Zinc Finger Domain Containing 1 2 3
  • Particularly Interesting New Cys-His Protein 1 2 3 4
  • LIM And Senescent Cell Antigen-Like Domains 1 2 3 5
  • Renal Carcinoma Antigen NY-REN-48 3 4
  • LIM-Type Zinc Finger Domains 1 2 3
  • Senescent Cell Antigen 2 3
  • PINCH-1 3 4
  • PINCH1 3 4
  • PINCH 3 4

External Ids for LIMS1 Gene

Previous GeneCards Identifiers for LIMS1 Gene

  • GC02P107110
  • GC02P107684
  • GC02P108755
  • GC02P108772
  • GC02P108826
  • GC02P109150

Summaries for LIMS1 Gene

Entrez Gene Summary for LIMS1 Gene

  • The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for LIMS1 Gene

LIMS1 (LIM Zinc Finger Domain Containing 1) is a Protein Coding gene. Diseases associated with LIMS1 include conotruncal heart malformations. Among its related pathways are Adhesion and Cytoskeletal Signaling. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for LIMS1 Gene

  • Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Gene Wiki entry for LIMS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMS1 Gene

Genomics for LIMS1 Gene

Regulatory Elements for LIMS1 Gene

Enhancers for LIMS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LIMS1 on UCSC Golden Path with GeneCards custom track

Promoters for LIMS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LIMS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LIMS1 Gene

Chromosome:
2
Start:
108,534,355 bp from pter
End:
108,687,246 bp from pter
Size:
152,892 bases
Orientation:
Plus strand

Genomic View for LIMS1 Gene

Genes around LIMS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIMS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIMS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMS1 Gene

Proteins for LIMS1 Gene

  • Protein details for LIMS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48059-LIMS1_HUMAN
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 1
    Protein Accession:
    P48059
    Secondary Accessions:
    • B2RAJ4
    • B7Z483
    • B7Z7R3
    • B7Z907
    • Q53TE0
    • Q9BS44

    Protein attributes for LIMS1 Gene

    Size:
    325 amino acids
    Molecular mass:
    37251 Da
    Quaternary structure:
    • Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors.

    Three dimensional structures from OCA and Proteopedia for LIMS1 Gene

    Alternative splice isoforms for LIMS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMS1 Gene

Proteomics data for LIMS1 Gene at MOPED

Post-translational modifications for LIMS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LIMS1 (LIMS1)

No data available for DME Specific Peptides for LIMS1 Gene

Domains & Families for LIMS1 Gene

Protein Domains for LIMS1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P48059

UniProtKB/Swiss-Prot:

LIMS1_HUMAN :
  • Contains 5 LIM zinc-binding domains.
Domain:
  • Contains 5 LIM zinc-binding domains.
genes like me logo Genes that share domains with LIMS1: view

Function for LIMS1 Gene

Molecular function for LIMS1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

Gene Ontology (GO) - Molecular Function for LIMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 20926685
genes like me logo Genes that share ontologies with LIMS1: view
genes like me logo Genes that share phenotypes with LIMS1: view

Animal Models for LIMS1 Gene

MGI Knock Outs for LIMS1:

miRNA for LIMS1 Gene

miRTarBase miRNAs that target LIMS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMS1 Gene

Localization for LIMS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMS1 Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIMS1 Gene COMPARTMENTS Subcellular localization image for LIMS1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for LIMS1 Gene

Pathways & Interactions for LIMS1 Gene

genes like me logo Genes that share pathways with LIMS1: view

Pathways by source for LIMS1 Gene

Gene Ontology (GO) - Biological Process for LIMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007569 cell aging TAS 7517666
GO:0045892 negative regulation of transcription, DNA-templated IDA 21390327
GO:0050678 NOT regulation of epithelial cell proliferation IMP 20926685
GO:0051894 positive regulation of focal adhesion assembly IMP 20926685
GO:0071560 cellular response to transforming growth factor beta stimulus IEP 21390327
genes like me logo Genes that share ontologies with LIMS1: view

No data available for SIGNOR curated interactions for LIMS1 Gene

Drugs & Compounds for LIMS1 Gene

(2) Drugs for LIMS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LIMS1: view

Transcripts for LIMS1 Gene

Unigene Clusters for LIMS1 Gene

LIM and senescent cell antigen-like domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIMS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - -
SP8: -
SP9: - - - -
SP10: - -
SP11: - - - - - - -
SP12:

Relevant External Links for LIMS1 Gene

GeneLoc Exon Structure for
LIMS1
ECgene alternative splicing isoforms for
LIMS1

Expression for LIMS1 Gene

mRNA expression in normal human tissues for LIMS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIMS1 Gene

This gene is overexpressed in Platelet (21.5) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIMS1 Gene



SOURCE GeneReport for Unigene cluster for LIMS1 Gene Hs.597715

mRNA Expression by UniProt/SwissProt for LIMS1 Gene

P48059-LIMS1_HUMAN
Tissue specificity: Expressed in most tissues except in the brain.
genes like me logo Genes that share expression patterns with LIMS1: view

Protein tissue co-expression partners for LIMS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LIMS1 Gene

Orthologs for LIMS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIMS1 35
  • 89.91 (n)
  • 97.63 (a)
MGC142792 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LIMS1 35
  • 90.01 (n)
  • 96.85 (a)
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lims1 35
  • 90.72 (n)
  • 99.39 (a)
Lims1 16
Lims1 36
  • 91 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LIMS1 35
  • 99.41 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Lims1 35
  • 90.72 (n)
  • 99.08 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves LIMS1 35
  • 82.87 (n)
  • 96.31 (a)
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
LIMS1 36
  • 97 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lims1 35
  • 82.87 (n)
  • 96.94 (a)
Str.8448 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12605 35
zebrafish
(Danio rerio)
Actinopterygii lims1 35
  • 80.85 (n)
  • 95.24 (a)
wufc32c03 35
lims1 36
  • 94 (a)
ManyToMany
lims2 36
  • 73 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5292 35
fruit fly
(Drosophila melanogaster)
Insecta stck 37
  • 65 (a)
stck 35
  • 65.2 (n)
  • 67.92 (a)
stck 36
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003429 35
  • 64.35 (n)
  • 65.93 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-97 37
  • 61 (a)
unc-97 35
  • 63.03 (n)
  • 60.58 (a)
unc-97 36
  • 56 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4597 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11312 36
  • 67 (a)
OneToMany
Species with no ortholog for LIMS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIMS1 Gene

ENSEMBL:
Gene Tree for LIMS1 (if available)
TreeFam:
Gene Tree for LIMS1 (if available)

Paralogs for LIMS1 Gene

genes like me logo Genes that share paralogs with LIMS1: view

Variants for LIMS1 Gene

Sequence variations from dbSNP and Humsavar for LIMS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs700878 -- 108,685,932(+) GCATG(A/G)CCTGA utr-variant-3-prime
rs700879 -- 108,685,231(-) CCCTC(C/G)TTCCA utr-variant-3-prime
rs700880 -- 108,662,515(+) GATCT(A/G)TTGGG intron-variant
rs826588 -- 108,682,162(+) AAATA(C/T)TTTGT intron-variant
rs826589 -- 108,683,580(+) TAAGT(A/T)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LIMS1 Gene

Variant ID Type Subtype PubMed ID
esv2720498 CNV Deletion 23290073
dgv1234e1 CNV Complex 17122850
dgv153e55 CNV Gain 17911159
nsv527491 CNV Loss 19592680
nsv834328 CNV Gain 17160897
nsv521122 CNV Loss 19592680

Variation tolerance for LIMS1 Gene

Gene Damage Index Score: 2.56; 44.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIMS1 Gene

HapMap Linkage Disequilibrium report
LIMS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMS1 Gene

Disorders for LIMS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LIMS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conotruncal heart malformations
  • double-outlet right ventricle
- elite association - COSMIC cancer census association via MalaCards
Search LIMS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LIMS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIMS1
genes like me logo Genes that share disorders with LIMS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LIMS1 Gene

Publications for LIMS1 Gene

  1. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. (PMID: 10022929) Tu Y. … Wu C. (Mol. Cell. Biol. 1999) 2 3 4 67
  2. Particularly interesting cysteine- and histidine-rich protein in cardiac development and remodeling. (PMID: 19952891) Liang X. … Chen J. (J. Investig. Med. 2009) 3 23
  3. Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. (PMID: 19117955) Yang Y. … Qin J. (J. Biol. Chem. 2009) 3 23
  4. Novel expression of PINCH in the central nervous system and its potential as a biomarker for human immunodeficiency virus-associated neurodegeneration. (PMID: 18459134) Rearden A. … Langford T.D. (J. Neurosci. Res. 2008) 3 23
  5. PINCH expression and its significance in esophageal squamous cell carcinoma. (PMID: 18957717) Zhu Z. … Sun X.F. (Dis. Markers 2008) 3 23

Products for LIMS1 Gene

Sources for LIMS1 Gene

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