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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIMK2 Gene

protein-coding   GIFtS: 69
GCID: GC22P031608

LIM Domain Kinase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Domain Kinase 21 2
EC 2.7.11.13 8
LIMK-23

External Ids:    HGNC: 66141   Entrez Gene: 39852   Ensembl: ENSG000001825417   OMIM: 6019885   UniProtKB: P536713   

Export aliases for LIMK2 gene to outside databases

Previous GC identifers: GC22P028304 GC22P029932 GC22P014569


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIMK2 Gene:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains
are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function
by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM
kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal
protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream
effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing
activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At
least three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Jul 2008)

GeneCards Summary for LIMK2 Gene: 
LIMK2 (LIM domain kinase 2) is a protein-coding gene. Diseases associated with LIMK2 include williams syndrome, and myotonic dystrophy, and among its related super-pathways are Actin Nucleation and Branching and Sema4D in semaphorin signaling. GO annotations related to this gene include protein serine/threonine kinase activity and protein heterodimerization activity. An important paralog of this gene is TESK2.

UniProtKB/Swiss-Prot: LIMK2_HUMAN, P53671
Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro

Gene Wiki entry for LIMK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIMK2 gene promoter:
         Max1   Pax-6   Tal-1beta   LCR-F1   NF-AT   E47   HEN1   NF-AT2   NF-AT1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIMK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LIMK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12

LIMK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031608:  view genomic region     (about GC identifiers)

Start:
31,608,225 bp from pter      End:
31,676,066 bp from pter
Size:
67,842 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIMK2_HUMAN, P53671 (See protein sequence)
Recommended Name: LIM domain kinase 2  
Size: 638 amino acids; 72232 Da
Subunit: Binds ROCK1 and LKAP. Interacts with PARD3. Interacts with NISCH (By similarity)
Subcellular location: Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and
the nucleus
Subcellular location: Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and
is scarcely translocated to the nucleus
Sequence caution: Sequence=AAB54055.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for LIMK2:
1X6A (3D)    
Secondary accessions: A8K6H5 Q7KZ80 Q7L3H5 Q96E10 Q99464 Q9UFU0
Alternative splicing: 3 isoforms:  P53671-1   P53671-2   P53671-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LIMK2: NX_P53671

Explore proteomics data for LIMK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and/or threonine residues by ROCK1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53671

  • 4/13 DME Specific Peptides for LIMK2 (P53671) (see all 13)
     IIHRDLN  KYHPECF  DRILEING  GMAYLHSM 

    LIMK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIMK2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001026971.1  NP_005560.1  NP_057952.1  

    ENSEMBL proteins: 
     ENSP00000384602   ENSP00000332687   ENSP00000388422   ENSP00000330470   ENSP00000339916  
     ENSP00000409522  
    Reactome Protein details: P53671
    Human Recombinant Protein Products for LIMK2: 
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    Novus Biologicals LIMK2 Proteins
    Novus Biologicals LIMK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LIMK2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS8954941
    GO:0005737cytoplasm TAS8537403
    GO:0005801cis-Golgi network IEA--
    GO:0016020membrane ----

    LIMK2 for ontologies           About GeneDecksing



    LIMK2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for LIMK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: LIM domain kinase 2 
    LIMK subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR001478 PDZ
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry P53671

    ProtoNet protein and cluster: P53671

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: LIMK2_HUMAN, P53671
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 2 LIM zinc-binding domains
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 protein kinase domain


    LIMK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMK2_HUMAN, P53671
    Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for LIMK2:
    LIM motif containing protein kinase 2,cytosolic,alternatively spliced in two isoforms LIMK2A and LIMK2B
    differentially regulated in a tissue specific manner

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS8537403
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    LIMK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LIMK2:
     Decreased nuclei size in G2M  Decreased substrate adherent c  Increased HPV18 LCR reporter a 

         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Limk2):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system 
     immune system  limbs/digits/tail  no phenotypic analysis  renal/urinary system  reproductive system 
     skeleton  vision/eye 

    LIMK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Limk2tm1.1Tnak for LIMK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIMK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LIMK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIMK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIMK2 

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMK2 (see all 33):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1273d hsa-let-7g hsa-miR-649 hsa-let-7a hsa-miR-23a hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidLIMK2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): LIMK2 (NM_005569)
    Sino Biological Human cDNA Clone for LIMK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LIMK2
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    Sirion Biotech Customized lentivirus for stable overexpression of LIMK2 
                         Customized lentivirus expression plasmids for stable overexpression of LIMK2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LIMK2 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35
    CDC42 Pathway0.41
    2Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    4Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    Actin-Based Motility by Rho Family GTPases0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for LIMK2 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases

    5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LIMK2 (see all 14)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Internalin Pathway
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for LIMK2
        Cytoskeletal Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for LIMK2 (see all 6)
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CCR3 signaling in eosinophils

    3 BioSystems Pathways for LIMK2
        Androgen receptor signaling pathway
    CDC42 signaling events
    RhoA signaling pathway


    5        Reactome Pathways for LIMK2
        Developmental Biology
    Sema4D induced cell migration and growth-cone collapse
    Semaphorin interactions
    Sema4D in semaphorin signaling
    Axon guidance


    3         Kegg Pathways  (Kegg details for LIMK2):
        Axon guidance
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton


    LIMK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIMK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/22 Interacting proteins for LIMK2 (P536711, 2, 3 ENSP000003399164) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-3380769 I2D: score=1 STRING: ENSP00000363921
    HIPK3Q9H4222, 3MINT-61744 I2D: score=2 
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    LIMK1P536673, ENSP000003367404I2D: score=2 STRING: ENSP00000336740
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=1 STRING: ENSP00000355731
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007283spermatogenesis IEA--
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0016310phosphorylation TAS8537403
    GO:0042325regulation of phosphorylation ----

    LIMK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LIMK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIMK2

    2 HMDB Compounds for LIMK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for LIMK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 62.6 3 15923181 (1), 16820362 (1)
    threonine 43.9 3 18000399 (1), 8537403 (1), 9089416 (1)
    serine 30.1 3 18000399 (1), 8537403 (1), 9089416 (1)
    tyrosine 0 2 9089416 (1)

    Search CenterWatch for drugs/clinical trials and news about LIMK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIMK2 gene (3 alternative transcripts): 
    NM_001031801.1  NM_005569.3  NM_016733.2  

    Unigene Cluster for LIMK2:

    LIM domain kinase 2
    Hs.474596  [show with all ESTs]
    Unigene Representative Sequence: NM_016733
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462625 ENST00000406516 ENST00000331728(uc003akh.3 uc003aki.3)
    ENST00000425203 ENST00000333611(uc003akk.3 uc011aln.2) ENST00000340552(uc003akj.3)
    ENST00000465937 ENST00000482270 ENST00000467301 ENST00000444929
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMK2 (see all 33):
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMK2

    Additional mRNA sequence: 

    AB451269.1 AB451396.1 AK092838.1 AK093554.1 AK291640.1 AK293774.1 AK299112.1 AK302553.1 
    AK314391.1 AL117466.1 BC013051.1 CR456513.1 D45906.1 D85527.1 

    24/32 DOTS entries (see all 32):

    DT.95270024  DT.95270027  DT.100815849  DT.100815843  DT.452864  DT.100815850  DT.120673574  DT.100815855 
    DT.120673583  DT.97864995  DT.40195147  DT.100698470  DT.91658352  DT.100705713  DT.100763362  DT.100815853 
    DT.102843229  DT.120673496  DT.92439138  DT.95362316  DT.97768439  DT.100042112  DT.100703519  DT.100815854 

    24/710 AceView cDNA sequences (see all 710):

    BQ940240 AI244632 BX337350 CR456513 BX380756 AU124920 AI969799 CB164761 
    CR625165 BC026040 CK903360 BU683581 BU681822 BQ050192 BX347985 BU553494 
    AI673744 CD675433 BF446788 AI394573 AU098732 BF223062 T32492 CB157798 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for LIMK2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                                -     -     -           -     -     -                                                                                       
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -     -                                                   
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                          -     -     -     -           -     -     -                                                                                       

    ExUns: 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:  -                                   -     -               
    SP2:  -                                   -     -               
    SP3:  -                                                         
    SP4:  -                                   -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for LIMK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIMK2 expression in normal human tissues (normalized intensities)      LIMK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LIMK2 Expression
    About this image


    LIMK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Blood (Hematopoietic System)
             neutrophils   
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Epithelium (Respiratory System)
             airway epithelial cells   

    See LIMK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIMK2

    SOURCE GeneReport for Unigene cluster: Hs.474596

    UniProtKB/Swiss-Prot: LIMK2_HUMAN, P53671
    Tissue specificity: Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas.
    LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and
    placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed

        SABiosciences Expression via Pathway-Focused PCR Array including LIMK2: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIMK2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Limk21 , 5 LIM motif-containing protein kinase 21, 5 88.35(n)1
    93.1(a)1
      11 (2.34 cM)5
    168861  NM_010718.31  NP_034848.11 
     33442565 
    chicken
    (Gallus gallus)
    Aves LIMK21 LIM domain kinase 2 79.47(n)
    86.52(a)
      396010  NM_205115.1  NP_990446.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    34(a)
    possible ortholog
    GL344151.1(43316-68492)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB038517.12   -- 77.94(n)    AB038517.1 
    zebrafish
    (Danio rerio)
    Actinopterygii limk21 LIM domain kinase 2 68.13(n)
    69.64(a)
      436924  NM_001002651.1  NP_001002651.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta LIMK16
    LIM-kinase1
    21(a)
    1 → many
    X(12478418-12486226)


    ENSEMBL Gene Tree for LIMK2 (if available)
    TreeFam Gene Tree for LIMK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIMK2 gene
    TESK22  TESK12  LIMK12  
    9 SIMAP similar genes for LIMK2 using alignment to 7 protein entries:     LIMK2_HUMAN (see all proteins):
    PPP1R14B    PPP1R14C    LIMK1    PPP1R14D    PPP1R14A    TESK2
    DKFZp686M05208    ABLIM1    PDLIM5

    LIMK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LIMK2
    PGOHUM00000241188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1364 SNPs in LIMK2 are shown (see all 1364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1996477731,2
    C--14571080(+) GGCCCA/CCCTCT 1 -- int10--------
    rs666414911,2
    C--14585677(+) CGTGC-/GTGT  
            
    GTGTG
    1 -- int10--------
    rs113179311,2
    C--14604334(+) GACTC-/AAAAAA 3 -- int1 us2k1 trp30--------
    rs665832671,2
    C--14604806(+) TTCCT-/CC    
       AGCAG
    CCTTG
    3 -- int1 us2k10--------
    rs339294111,2
    C--14610119(+) AAAAAA/-GTTGA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1463273401,2
    C--15528956(+) TTGAA-/ACTC  
            
    AGTTG
    1 -- us2k10--------
    rs1496969181,2
    --15529134(+) GAGTCA/GCCTGA 1 -- us2k10--------
    rs1467174291,2
    --15529267(+) CTGGGA/TGCCTT 1 -- us2k10--------
    rs1392852711,2
    C--15529314(+) GTTTTA/GGTTCC 1 -- us2k10--------
    rs1441163701,2
    --15529459(+) TAATTC/GAATAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LIMK2 (31608225 - 31676066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LIMK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2543296CNV Insertion19546169
    nsv459871CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601988    OMIM disorders: --

    13 diseases for LIMK2:    About MalaCards
    williams syndrome    myotonic dystrophy    male infertility    infertility
    retinoblastoma    pancreatic cancer    alcoholism    pancreatitis
    prostate cancer    endotheliitis    prostatitis    breast cancer
    neuronitis


    LIMK2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for LIMK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    williams syndrome 54.9 1 9089416 (1)
    metastasis 0 1 17188549 (1)
    tumors 0 1 19881550 (1)
    cancer 0 1 17188549 (1)

    Genetic Association Database (GAD): LIMK2
    Human Genome Epidemiology (HuGE) Navigator: LIMK2 (4 documents)

    Export disorders for LIMK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIMK2 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with LIMK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. (PubMed id 8537403)1, 2, 3, 9 Okano I.... Mizuno K. (1995)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    3. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. (PubMed id 11018042)1, 2, 9 Sumi T.... Nakamura T. (2001)
    4. Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PubMed id 11340065)1, 2, 9 Sumi T....Nakamura T. (2001)
    5. A genome-wide association study for diabetic nephropa thy genes in African Americans. (PubMed id 21150874)1, 4 McDonough C.W....Bowden D.W. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Identification of Potentially Damaging Amino Acid Substitutions Leading to Human Male Infertility. (PubMed id 19369647)1, 4 Kuzmin A....Varmuza S. (2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3985 HGNC: 6614 AceView: LIMK2 Ensembl:ENSG00000182541 euGenes: HUgn3985
    ECgene: LIMK2 Kegg: 3985 H-InvDB: LIMK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIMK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LIMK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIMK2 gene:
    Search GeneIP for patents involving LIMK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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