LIMK1 Gene
protein-coding GIFtS: 67
GCID: GC07P073497
|
|
LIM domain kinase 1
| |
Aliases
for LIMK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| LIM Domain Kinase 11 2 | | LIMK1 2 3 | | LIMK-12 3 | | EC 2.7.11.13 8 | | LIM Motif-Containing Protein Kinase2 |
Export aliases for LIMK1 gene to outside databasesPrevious GC identifers: GC07P072138 GC07P072896 GC07P072910 GC07P072942 GC07P073136 GC07P069382 |
Summaries
for LIMK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LIMK1:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains arehighly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by bindingto DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to asmall subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 isa serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actinbinding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellularprocesses associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role inbrain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williamssyndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq,Feb 2011)
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667Function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics.Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases includingROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actincytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cellcycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubuledisassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negativeeffect on actin cytoskeletal changes
Gene Wiki entry for LIMK1
|
Genomic Views
for LIMK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079593.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LIMK1 gene promoter:
CREB SRF deltaCREB SRF (504 AA) STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for LIMK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23LIMK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P073497: view genomic region
(about GC identifiers)
Start:
|
73,497,263 bp from pter |
End:
|
73,536,855 bp from pter |
Size:
|
39,593 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 72,831,228-72,869,926 |
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Proteins
for LIMK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667 (See
protein sequence)Recommended Name: LIM domain kinase 1 Size: 647 amino acids; 72585 Da
Subunit: Interacts (via LIM domain) with the cytoplasmic domain of NRG1 (By similarity). Interacts with NISCH (Bysimilarity). Interacts with RLIM and RNF6 (By similarity). Self-associates to form homodimers. Interacts withHSP90AA1; this interaction promotes LIMK1 dimerization and subsequent transphosphorylation. Interacts with CDN1C.Interacts with SSH1. Interacts with ROCK1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm
1 PDB 3D structure from  and Proteopedia  for LIMK1:3S95 (3D)
Secondary accessions: B7Z6I8 D3DXF4 D3DXF5 O15283 Q15820 Q15821 Q75MU3 Q9Y5Q1Alternative splicing: 4 isoforms: P53667-1 P53667-2 P53667-3 P53667-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LIMK1: NX_P53667
Post-translational modifications:
Autophosphorylated (By similarity). Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation.Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 byMAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actinreorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1.Phosphorylated by CDC42BP1
Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome,modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM (Bysimilarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P53667
4/26 DME Specific Peptides for LIMK1 (P53667) (see all 26)
LIMK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191355.1 NP_002305.1
ENSEMBL proteins: ENSP00000409717 ENSP00000336740 ENSP00000414606 ENSP00000396480 ENSP00000394098 ENSP00000444452 Reactome Protein details: P53667
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
LIMK1 for ontologies About GeneDecksing
LIMK1 Antibody Products:
Assay Products for LIMK1: |
Protein
Domains /
Families
for LIMK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LIMK1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P53667ProtoNet protein and cluster: P53667 2 Blocks protein families: IPB001478 PDZ/DHR/GLGF domain IPB001781 Zn-binding protein
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 2 LIM zinc-binding domainsSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 protein kinase domain |
Function
for LIMK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667Function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics.Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases includingROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actincytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cellcycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubuledisassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negativeeffect on actin cytoskeletal changesCatalytic activity: ATP + a protein = ADP + a phosphoprotein Genatlas biochemistry entry for LIMK1:LIM motif containing protein kinase 1,serine only protein kinase,cytosolic,highly expressed in neurons,regulating actindynamics through phosphorylation of cofilin,which leads to accumulation of F-actin,deleted in Williamssyndrome,claimed to be responsible for the cognitive defect of the syndrome,but contradictory evidence,see WBS1
Enzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): LIMK1 (NM_002314) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIMK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMK1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
LIMK1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for LIMK1:
Animal Models:
Mouse knock-out Limk1tm1Zpj for LIMK1
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Limk1):
LIMK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LIMK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | G-protein signaling_RAC1 in cellular process | | | 3 | Sema4D in semaphorin signaling | | | 4 | Actin Nucleation by ARP-WASP Complex | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 EMD Millipore Pathways for LIMK1 (see all 9)
5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LIMK1 (see all 14)
1 
Cell Signaling Technology (CST) Pathway for LIMK1
5/10  GeneGo (Thomson Reuters) Pathways for LIMK1 (see all 10)
5/7  BioSystems Pathways for LIMK1 (see all 7)
5/14 
Reactome Pathways for LIMK1 (see all 14)
3 
Kegg Pathways (Kegg details for LIMK1):
LIMK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIMK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for LIMK1 (P536671, 2, 3 ENSP000003367404) via UniProtKB, MINT, STRING, and/or I2D (see all 57)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PAK1 | Q131531, 3, ENSP000002785684 | EBI-444403,EBI-1307 I2D:
score=3 STRING: ENSP00000278568 | | MAPKAPK2 | P491372, 3, ENSP000003560704 | MINT-2833388 I2D:
score=1 STRING: ENSP00000356070 | | MMP14 | P502811, 3, ENSP000003082084 | EBI-444403,EBI-992788 I2D:
score=1 STRING: ENSP00000308208 | | PRKACA | P176122, 3, ENSP000003095914 | MINT-7228333 I2D:
score=1 STRING: ENSP00000309591 | | CFL1 | P235282, 3, ENSP000003096294 | MINT-6173989 I2D:
score=4 STRING: ENSP00000309629 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
LIMK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LIMK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LIMK1 for compounds About GeneDecksing
 Browse Tocris compounds for LIMK1
2 HMDB Compounds for LIMK1 About this table
6 Novoseek chemical compound relationships for LIMK1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leptomycin b |
62.1 |
1 |
10051454 (1) |
| threonine |
60.7 |
18 |
8537403 (2), 10512679 (1), 16641196 (1), 10051454 (1) (see all 16) |
| serine |
50 |
21 |
16641196 (2), 8537403 (2), 10512679 (1), 10051454 (1) (see all 17) |
| nocodazole |
27.5 |
1 |
15897190 (1) |
| tyrosine |
5.62 |
4 |
8183554 (1), 17607944 (1), 7478547 (1), 9915950 (1) |
| zinc |
1.13 |
2 |
8183554 (1), 8812460 (1) |
Search CenterWatch for drugs/clinical trials and news about LIMK1
|
Transcripts
for LIMK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LIMK1 gene (3 alternative transcripts): NM_001204426.1 NM_002314.3 NM_016735.1 Unigene Cluster for LIMK1: LIM domain kinase 1 Hs.647035 [show with all ESTs]Unigene Representative Sequence: NM_00231410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418310 ENST00000336180(uc003uaa.2 uc010lbl.2 uc003uab.3)
ENST00000435201 ENST00000423685 ENST00000486361 ENST00000491052 ENST00000483414(uc003uac.1)
ENST00000476792 ENST00000419043 ENST00000538333
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LIMK1 (NM_002314) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LIMK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIMK1 |
Additional cDNA sequence: AK026544.1 AK290162.1 AK300382.1 D26309.1 14 DOTS entries: DT.413487 DT.75135298 DT.121102277 DT.100000274 DT.100693244 DT.86849351 DT.100751207 DT.121102264 DT.95275758 DT.100751206 DT.101959346 DT.92415716 DT.40214192 DT.97822434 24/114 AceView cDNA sequences (see all 114): BQ056643 NM_016735 D26309 AA078560 CF594115 BQ061327 BQ187976 BE674566 BQ439916 BF516215 NM_002314 BQ185164 BQ896940 AK026544 CK431098 BQ876497 CA489388 AF134379 AL040089 BG420081 AA532443 AV728747 BE261744 BI599302
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for LIMK1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | · | 19c |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LIMK1
|
Expression
for LIMK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LIMK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAGGGAG
About this image
See LIMK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIMK1
SOURCE GeneReport for Unigene cluster: Hs.647035
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667Tissue specificity: Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout thedifferent regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heartand skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Arrays including LIMK1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIMK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LIMK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIMK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMK1 |
Orthologs
for LIMK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LIMK1 gene from 6/23 species (see all 23) About this table
ENSEMBL Gene Tree for LIMK1 (if available)
TreeFam Gene Tree for LIMK1 (if available) |
Paralogs
for LIMK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LIMK1 gene
- LIMK22 TESK22 TESK12
18/20 SIMAP similar genes for LIMK1 using alignment to 5 protein entries: LIMK1_HUMAN (see all proteins)
(see all similar genes):LIMK2 LHx4 LHX3 CRIP1 LHX2 LIMS1
CDC2 LHX6 LMO4 CCRK LHX4 LHX8
LMO3 CRIP2 DKFZp564L2416 MYO3A LMO2 MET
LIMK1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for LIMK1
PGOHUM00000234970
|
Genomic Variants
for LIMK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LIMK1 (73497263 - 73536855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LIMK1
2 Indels: 12935 28685
Human Gene Mutation Database (HGMD): LIMK1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for LIMK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LIMK1 for disorders About GeneDecksing
OMIM gene information: 601329
OMIM disorders: --
UniProtKB/Swiss-Prot: LIMK1_HUMAN, P53667
Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygousdeletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over betweenhighly homologous low-copy repeat sequences flanking the deleted region
20/23  diseases for LIMK1 (see all 23): About MalaCardswilliams syndrome supravalvular aortic stenosis williams-beuren syndrome aortic valve stenosis
intracranial aneurysm intellectual disability myotonic dystrophy kidney disease
prostate cancer breast cancer alzheimer's disease gastric cancer
pancreatic cancer lung cancer prostatitis pancreatitis
fibrosis hypertension carcinoma cerebritis
1 disease from the University of Copenhagen DISEASES database for LIMK1:Williams-Beuren syndrome 10/12 Novoseek disease relationships for LIMK1 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| williams syndrome |
86.1 |
10 |
14745832 (3), 16216290 (2), 19662944 (1), 14684741 (1) (see all 7) |
| aortic stenosis supravalvular |
63.4 |
2 |
9637430 (1), 19568270 (1) |
| cognitive deficit |
28.1 |
2 |
16216290 (1) |
| prostate cancer |
23.3 |
11 |
12821664 (3), 15908432 (1), 18424072 (1), 12777619 (1) |
| intracranial aneurysm |
19.5 |
1 |
16611674 (1) |
| breast cancer |
13.4 |
12 |
16381000 (3), 16763828 (2), 18332102 (1), 17559677 (1) (see all 5) |
| metastasis |
12.1 |
10 |
16381000 (2), 16651380 (2), 17188549 (1), 17559677 (1) (see all 5) |
| cancer |
7.31 |
6 |
10224665 (1), 17188549 (1), 19778628 (1), 12777619 (1) (see all 6) |
| carcinoma squamous cell |
0 |
2 |
8537403 (1), 12655149 (1) |
| chromosomal aberrations |
0 |
1 |
17559677 (1) |
Human Genome Epidemiology (HuGE) Navigator: LIMK1 (8 documents)
Export disorders for LIMK1 gene to outside databases
|
Publications
for LIMK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LIMK1 gene, integrated from 9 sources (see all 170):
(articles sorted by number of sources associating them with LIMK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. (PubMed id 8812460)1, 2, 3, 9 Osborne L.R....Tsui L.C. (1996)
- Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. (PubMed id 10652353)1, 2, 9 Ohashi K.... Mizuno K. (2000)
- MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. (PubMed id 16456544)1, 2, 9 Kobayashi M....Mizuno K. (2006)
- Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. (PubMed id 8183554)1, 2, 9 Mizuno K....Nakamura T. (1994)
- Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin. (PubMed id 11413130)1, 2, 9 Dan C....Minden A. (2001)
- Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (2005)
- Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. (PubMed id 11340065)1, 2, 9 Sumi T....Nakamura T. (2001)
- LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. (PubMed id 8689688)1, 2, 9 Frangiskakis J.M....Keating M.T. (1996)
- Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. (PubMed id 21682918)1, 2 McConnell B.V.... Gutierrez-Hartmann A. (2011)
- The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. (PubMed id 18028908)1, 2 Acevedo K....Bernard O. (2007)
|
External Searches for LIMK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing LIMK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LIMK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LIMK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LIMK1 gene:
Search GeneIP for patents involving LIMK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LIMK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for LIMK1 | | OriGene shRNA RFP for LIMK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LIMK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LIMK1 | | | OriGene Protein Over-expression Lysate for LIMK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LIMK1 | | OriGene 3'-UTR Clone for LIMK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LIMK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LIMK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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