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LIME1 Gene

protein-coding   GIFtS: 50
GCID: GC20P062366

Lck Interacting Transmembrane Adaptor 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lck Interacting Transmembrane Adaptor 11 2     LP80672
LIME2 3 5     dJ583P15.42
Lck-Interacting Membrane Protein2 3     Lck-Interacting Transmembrane Adapter 12
Lck-Interacting Molecule2 3     

External Ids:    HGNC: 260161   Entrez Gene: 549232   Ensembl: ENSG000002038967   OMIM: 6098095   UniProtKB: Q9H4003   
ORGUL members:         

Export aliases for LIME1 gene to outside databases

Previous GC identifers: GC20P061839 GC20P059100


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LIME1 Gene:
LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic
cells, particularly T cells (Brdickova et al., 2003 (PubMed 14610046); Hur et al., 2003 (PubMed
14610044)).(supplied by OMIM, Mar 2008)

GeneCards Summary for LIME1 Gene:
LIME1 (Lck interacting transmembrane adaptor 1) is a protein-coding gene. Diseases associated with LIME1 include inflammatory bowel disease. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is ENSG00000273047.

UniProtKB/Swiss-Prot: LIME1_HUMAN, Q9H400
Function: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen
receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated
inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal
intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2,
GRAP2, and other signaling molecules

Gene Wiki entry for LIME1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIME1 gene promoter:
         AhR   NF-1   AML1a   NRSF form 1   NRSF form 2   GATA-2   Arnt   C/EBPalpha   Cart-1   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LIME1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIME1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

LIME1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIME1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P062366:  view genomic region     (about GC identifiers)

Start:
62,366,815 bp from pter      End:
62,370,460 bp from pter
Size:
3,646 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIME1_HUMAN, Q9H400 (See protein sequence)
Recommended Name: Lck-interacting transmembrane adapter 1  
Size: 295 amino acids; 31288 Da
Subunit: When phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, and GRB2 (By
similarity). When phosphorylated in response to TCR stimulation and/or CD4 co-stimulation, interacts with LCK,
CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 and GRAP2
Secondary accessions: E1P5K5 E1P5K6 Q5JWJ2 Q6XYB3 Q9NX69
Alternative splicing: 2 isoforms:  Q9H400-1   Q9H400-2   

Explore the universe of human proteins at neXtProt for LIME1: NX_Q9H400

Explore proteomics data for LIME1 at MOPED

Post-translational modifications: 

  • Palmitoylation of Cys-28 and Cys-31 is required for raft targeting1
  • Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which
    leads to the recruitment of SH2-containing proteins1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LIME1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060276.2  
    ENSEMBL proteins: 
     ENSP00000414506   ENSP00000309521   ENSP00000476772  

    LIME1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LIME1
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    Novus Biologicals LIME1 Proteins
    Novus Biologicals LIME1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LIME1

    LIME1 Antibody Products:

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    ThermoFisher Antibodies for LIME1
    LSBio Antibodies in human, mouse, rat for LIME1

    LIME1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LIME1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LIME1
    Cloud-Clone Corp. CLIAs for LIME1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026072 Lime1

    Graphical View of Domain Structure for InterPro Entry Q9H400

    ProtoNet protein and cluster: Q9H400


    LIME1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIME1_HUMAN, Q9H400
    Function: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen
    receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated
    inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal
    intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2,
    GRAP2, and other signaling molecules

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding ----
         
    LIME1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lime1):
     hematopoietic system  immune system  normal 

    LIME1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lime1tm1Mal for LIME1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LIME1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LIME1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIME1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LIME1

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LIME1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: LIME1 (NM_017806)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIME1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIME1_HUMAN, Q9H400: Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited
    to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0019815B cell receptor complex ----

    LIME1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LIME1 About    
    See pathways by source

    SuperPathContained pathways About
    1B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    1 BioSystems Pathway for LIME1
        B Cell Receptor Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIME1
    Interactions:

        Search GeneGlobe Interaction Network for LIME1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for LIME1 (Q9H4003 ENSP000003095214) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCKP062393, ENSP000003378254I2D: score=1 STRING: ENSP00000337825
    PLCG2P168853, ENSP000003523364I2D: score=1 STRING: ENSP00000352336
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    LYNP079483I2D: score=1 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0014066regulation of phosphatidylinositol 3-kinase signaling ----
    GO:0042345regulation of NF-kappaB import into nucleus ----
    GO:0043405regulation of MAP kinase activity ----
    GO:0050852T cell receptor signaling pathway IEA--

    LIME1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIME1

    1 HMDB Compound for LIME1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LIME1 gene: 
    NM_017806.2  

    Unigene Cluster for LIME1:

    Lck interacting transmembrane adaptor 1
    Hs.233220  [show with all ESTs]
    Unigene Representative Sequence: AY203957
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496820 ENST00000444951 ENST00000490824 ENST00000465591 ENST00000309546
    ENST00000487026 ENST00000480139 ENST00000493265 ENST00000489212 ENST00000476183
    ENST00000494776
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LIME1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LIME1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIME1
      QuantiTect SYBR Green Assays in human, mouse, rat LIME1
      QuantiFast Probe-based Assays in human, mouse, rat LIME1

    Additional mRNA sequence: 

    AK000413.1 AY203957.1 BC017016.1 

    12 DOTS entries:

    DT.100822146  DT.100822147  DT.101982338  DT.95185410  DT.97847666  DT.97847663  DT.100029801  DT.120824945 
    DT.92425170  DT.95251585  DT.100822149  DT.109754 

    Selected AceView cDNA sequences (see all 291):

    AW192357 CB162103 BM912404 CR593736 BF437481 CD722647 BM423669 BC028349 
    BC052306 NM_181484 AK000413 AK122912 CR616647 BM916471 BM974581 AI273469 
    NM_020062 AI240959 CR592410 NM_017806 BQ939861 BM846083 BC019338 AI261465 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LIME1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCTCCTGC
    LIME1 Expression
    About this image

    LIME1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIME1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.233220

    UniProtKB/Swiss-Prot: LIME1_HUMAN, Q9H400
    Tissue specificity: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and
    plasma cells, and in various hematopoietic cell lines (at protein level)

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for LIME1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lime11 , 5 Lck interacting transmembrane adaptor 11, 5 76.04(n)1
    66.27(a)1
      2 (103.63 cM)5
    726991  NM_023684.21  NP_076173.11 
     1813800785 


    ENSEMBL Gene Tree for LIME1 (if available)
    TreeFam Gene Tree for LIME1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LIME1 gene
    ENSG000002730472  

    LIME1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LIME1 (see all 21)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927072701,2
    --62368050(+) GACCCC/TTGGCC 1 -- ut510--------
    rs1481850041,2
    C--62368074(+) GTGCCC/TTCCTG 1 -- int10--------
    rs1122530791,2
    C,F--62368277(+) GATCCG/CCAAGA 1 -- int11Minor allele frequency- C:0.50NA 2
    rs603500611,2
    C--62368537(+) TGTGG-/CCCTGT 1 -- int13Minor allele frequency- C:0.00NA CSA 6
    rs12753301,2
    C,F--62368539(+) TGGCCG/CTGTGG 1 -- int16Minor allele frequency- C:0.45NA EA 1678
    rs1503184851,2
    --62368600(+) CCACAA/GCTGTC 1 -- int10--------
    rs11516231,2
    C,F,A--62368606(+) CTGTCC/TTGCCC 1 -- int111Minor allele frequency- T:0.33NA WA CSA EA 373
    rs22365101,2
    C,F--62368804(+) GCAGCC/TGCGGG 1 -- int15Minor allele frequency- T:0.38NA EA 246
    rs2009305171,2
    C--62368876(+) TTCTTA/CTGTCC 1 -- int10--------
    rs1838928511,2
    C--62368900(+) TTCACA/GGGATG 1 -- ut510--------

    HapMap Linkage Disequilibrium report for LIME1 (62366815 - 62370460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LIME1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722959CNV Deletion23290073
    nsv913250CNV Loss21882294
    dgv4647n71CNV Loss21882294
    dgv4644n71CNV Loss21882294
    dgv4649n71CNV Loss21882294
    dgv4645n71CNV Loss21882294
    nsv913213CNV Loss21882294
    dgv4618n71CNV Loss21882294
    nsv913256CNV Loss21882294
    dgv4651n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIME1
    DNA2.0 Custom Variant and Variant Library Synthesis for LIME1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609809    OMIM disorders: --

    1 disease for LIME1:    
    About MalaCards
    inflammatory bowel disease


    LIME1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LIME1

    Export disorders for LIME1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIME1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with LIME1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PubMed id 16160011)1, 2 Tedoldi S....Horejsi V. (Blood 2006)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. (PubMed id 14610044)1, 2 Hur E.M.... Yun Y. (J. Exp. Med. 2003)
    6. LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (PubMed id 14610046)1, 2 Brdickova N....Horejsi V. (J. Exp. Med. 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    10. LIME mediates immunological synapse formation through activation of VAV. (PubMed id 22395814)1 Son M....Yun Y. (Mol. Cells 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54923 HGNC: 26016 AceView: FLJ20406andSLC2A4RGandKIAA1847 Ensembl:ENSG00000203896 euGenes: HUgn54923
    ECgene: LIME1 H-InvDB: LIME1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIME1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIME1 gene:
    Search GeneIP for patents involving LIME1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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