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LIMD1 Gene

protein-coding   GIFtS: 58
GCID: GC03P045611

LIM Domains Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
LIM Domains Containing 11 2
LIM Domain-Containing Protein 12

External Ids:    HGNC: 66121   Entrez Gene: 89942   Ensembl: ENSG000001447917   OMIM: 6045435   UniProtKB: Q9UGP43   

Export aliases for LIMD1 gene to outside databases

Previous GC identifers: GC03P044877 GC03P045455 GC03P045596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LIMD1 Gene:
LIMD1 (LIM domains containing 1) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic
regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of
HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin
transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits
E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements.
Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability
of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor
signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation

Gene Wiki entry for LIMD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIMD1 gene promoter:
         ER-alpha   AML1a   AP-1   ATF-2   STAT5A   CUTL1   IRF-2   CP2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIMD1 promoter sequence
   Search Chromatin IP Primers for LIMD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIMD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

LIMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMD1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045611:  view genomic region     (about GC identifiers)

Start:
45,596,886 bp from pter      End:
45,727,830 bp from pter
Size:
130,945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4 (See protein sequence)
Recommended Name: LIM domain-containing protein 1  
Size: 676 amino acids; 72190 Da
Subunit: Interacts (via LIM domains) with TRAF6. Found in a complex with TRAF6, PRKCZ and SQSTM1. Interacts (via
LIM domains) SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with SQSTM1 and
RB1. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with EIF4E, AGO1, AGO2,
DCP2, DDX6, LATS1, LATS2, EGLN1/PHD2, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM zinc-binding 2) with isoform
1 and isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain)
Secondary accessions: Q17RQ1 Q9BQQ9 Q9NQ47

Explore the universe of human proteins at neXtProt for LIMD1: NX_Q9UGP4

Explore proteomics data for LIMD1 at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LIMD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055055.1  
    ENSEMBL proteins: 
     ENSP00000394537   ENSP00000273317  

    LIMD1 Human Recombinant Protein Products:

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    antibodies-online proteins for LIMD1 (7 products) 

     
    antibodies-online peptides for LIMD1

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    antibodies-online antibodies for LIMD1 (37 products) 

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    antibodies-online kits for LIMD1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR028734 LIMD1

    Graphical View of Domain Structure for InterPro Entry Q9UGP4

    ProtoNet protein and cluster: Q9UGP4

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Find genes that share domains with LIMD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMD1_HUMAN, Q9UGP4
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
    involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
    gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
    microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic
    regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of
    HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin
    transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits
    E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements.
    Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability
    of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor
    signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation
    Induction: Down-regulated in lung cancer

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI15542589
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with LIMD1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Limd1):
     hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with LIMD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Limd1tm1Gdl for LIMD1

       genOway: Develop your customized and physiologically relevant rodent model for LIMD1

    miRNA
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    miRTarBase miRNAs that target LIMD1:
    hsa-mir-455-3p (MIRT037903), hsa-mir-124-3p (MIRT022837), hsa-mir-24-3p (MIRT030543), hsa-mir-92a-3p (MIRT049139)

    Block miRNA regulation of human, mouse, rat LIMD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LIMD1 (see all 39):
    hsa-miR-3678-3p hsa-miR-328 hsa-let-7d hsa-miR-485-3p hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-98
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIMD1_HUMAN, Q9UGP4: Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction,
    focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm.
    Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down-regulation and/or
    elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient
    prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with
    low-tumor grade and better patient prognosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IDA15542589
    GO:0005737cytoplasm IDA15542589
    GO:0005912adherens junction IDA--
    GO:0005925focal adhesion IDA18439753

    Find genes that share ontologies with LIMD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LIMD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with LIMD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for LIMD1):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIMD1
    Interactions:

        GeneGlobe Interaction Network for LIMD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for LIMD1 (Q9UGP41, 2, 3 ENSP000002733174) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3, ENSP000003042264MINT-61750 I2D: score=3 STRING: ENSP00000304226
    RARAP102763, ENSP000002540664I2D: score=1 STRING: ENSP00000254066
    RPP14O950593, ENSP000002959594I2D: score=2 STRING: ENSP00000295959
    STACQ994693, ENSP000002731834I2D: score=1 STRING: ENSP00000273183
    TRAF6Q9Y4K33I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0002076osteoblast development ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS10647888
    GO:0007010cytoskeleton organization IMP--

    Find genes that share ontologies with LIMD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIMD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LIMD1 gene: 
    NM_014240.2  

    Unigene Cluster for LIMD1:

    LIM domains containing 1
    Hs.193370  [show with all ESTs]
    Unigene Representative Sequence: NM_014240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465039 ENST00000440097 ENST00000273317(uc003coq.3) ENST00000474665

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    Selected qRT-PCR Assays for microRNAs that regulate LIMD1 (see all 39):
    hsa-miR-3678-3p hsa-miR-328 hsa-let-7d hsa-miR-485-3p hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-98
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      QuantiFast Probe-based Assays in human, mouse, rat LIMD1

    Additional mRNA sequence: 

    AJ132408.1 AK021508.1 AK125901.1 BC027712.2 BC117236.1 BC117238.1 M80651.1 

    9 DOTS entries:

    DT.409014  DT.91952643  DT.40268098  DT.95264356  DT.204680  DT.100760931  DT.100680680  DT.91702365 
    DT.92045826 

    Selected AceView cDNA sequences (see all 84):

    BX099207 BU155896 BM751219 AA746316 BM765265 BM766194 BC027712 AA613893 
    AI866731 BI088163 BM764476 BX501498 AU117429 BG180535 BE908302 BM742168 
    BG258305 BE727848 AW294379 BX444955 BF876637 BX419713 BM742312 BX451510 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LIMD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAACACT
    LIMD1 Expression
    About this image

    LIMD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIMD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193370

    UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
    Tissue specificity: Expressed in normal and breast cancer tissues (at protein level). Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LIMD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Limd11 , 5 LIM domains containing 11, 5 80.85(n)1
    78.2(a)1
      9 (74.00 cM)5
    298061  NM_013860.21  NP_038888.21 
     1234787015 
    chicken
    (Gallus gallus)
    Aves LIMD11 LIM domains containing 1 81.38(n)
    88.83(a)
      420701  XM_418800.4  XP_418800.4 
    lizard
    (Anolis carolinensis)
    Reptilia LIMD16
    LIM domains containing 1
    52(a)
    1 ↔ 1
    GL343324.1(108030-152028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.170312 Transcribed sequence with moderate similarity to protein more 76.93(n)    BX781131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5627931 LIM domain-containing protein 1-like 70.32(n)
    70.79(a)
      562793  XM_686167.6  XP_691259.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110633 ligand-dependent nuclear receptor
    interactor
    66(a)   12C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea zyx-13 LIM domain containing proteins 42(a)   II(13057045-13070542)   --


    ENSEMBL Gene Tree for LIMD1 (if available)
    TreeFam Gene Tree for LIMD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LIMD1 gene
    LPP2  FBLIM12  TRIP62  ABLIM32  WTIP2  AJUBA2  DMTN2  ZYX2  
    ABLIM22  ABLIM12  
    7 SIMAP similar genes for LIMD1 using alignment to 2 protein entries:     LIMD1_HUMAN (see all proteins):
    WTIP    LHX8    LIMS1    LHX4    ZYX    AJUBA
    TRIP6

    Find genes that share paralogs with LIMD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LIMD1 (see all 1916)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487088901,2
    --45634365(+) AATGGA/CGTGGG 1 -- us2k10--------
    rs1892683231,2
    C--45634400(+) AAAAAA/CCGCAT 1 -- us2k10--------
    rs1812534921,2
    --45634403(+) AAACGA/CATGTT 1 -- us2k10--------
    rs759336001,2
    C--45634439(+) AGTTAT/GCAGAA 1 -- us2k12Minor allele frequency- G:0.08CSA WA 120
    rs1849291211,2
    --45634812(+) GGGGGC/TGCCAA 1 -- us2k10--------
    rs797910091,2
    F--45634830(+) GGCCTG/CGTGTC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1177177691,2
    C--45634859(+) CACTTG/CCAGAT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs2017749721,2
    --45634941(+) GCAGG-/CACAACG 1 -- us2k10--------
    rs1429726461,2
    C--45634942(+) CAGGC-/ACAACGAG 1 -- us2k10--------
    rs1138804731,2
    C--45634945(+) GCACAACGAG/
            
    ACTTT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for LIMD1 (45596886 - 45727830 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LIMD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725221CNV Deletion23290073
    esv2725223CNV Deletion23290073
    esv2725222CNV Deletion23290073
    nsv3795CNV Insertion18451855
    esv34130CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604543    OMIM disorders: --


    Find genes that share disorders with LIMD1           About GenesLikeMe

    Genetic Association Database (GAD): LIMD1
    Human Genome Epidemiology (HuGE) Navigator: LIMD1 (1 document)

    Export disorders for LIMD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIMD1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with LIMD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 10647888)1, 2, 3 Kiss H.... Dumanski J.P. (Hum. Genet. 1999)
    2. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. (PubMed id 15542589)1, 2, 9 Sharp T.V.... Boshoff C. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (Nat. Cell Biol. 2012)
    4. LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. (PubMed id 20226061)1, 4 Ghosh S....Panda C.K. (Mol. Cancer 2010)
    5. Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. (PubMed id 18712738)1, 2 Spendlove I.... Sharp T.V. (Int. J. Cancer 2008)
    6. Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers. (PubMed id 18439753)1, 2 Huggins C.J. and Andrulis I.L. (Cancer Lett. 2008)
    7. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274)1, 2 Feng Y. and Longmore G.D. (Mol. Cell. Biol. 2005)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 11352561)1, 2 Kiss H.... Dumanski J.P. (Genomics 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8994 HGNC: 6612 AceView: LIMD1 Ensembl:ENSG00000144791 euGenes: HUgn8994
    ECgene: LIMD1 Kegg: 8994 H-InvDB: LIMD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIMD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LIMD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIMD1 gene:
    Search GeneIP for patents involving LIMD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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