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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIMD1 Gene

protein-coding   GIFtS: 51
GCID: GC03P045611

LIM domains containing 1

 Explore 9 diseases affiliated with
LIMD1 via our new
 Human Malady Compendium 
Biological research products
for LIMD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
LIM Domains Containing 11 2
LIM Domain-Containing Protein 12

External Ids:    HGNC: 66121   Entrez Gene: 89942   Ensembl: ENSG000001447917   OMIM: 6045435   UniProtKB: Q9UGP43   

Export aliases for LIMD1 gene to outside databases

Previous GC identifers: GC03P044877 GC03P045455 GC03P045596


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved
in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene
transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA
(miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by
bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a
transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively
regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription,
and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast
development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate
adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts.
May act as a tumor suppressor by inhibiting cell proliferation

Gene Wiki entry for LIMD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIMD1 gene promoter:
         ER-alpha   AML1a   AP-1   ATF-2   STAT5A   CUTL1   IRF-2   CP2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIMD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LIMD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

LIMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMD1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P045611:  view genomic region     (about GC identifiers)

Start:
45,596,886 bp from pter      End:
45,727,830 bp from pter
Size:
130,945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4 (See protein sequence)
Recommended Name: LIM domain-containing protein 1  
Size: 676 amino acids; 72190 Da
Subunit: Interacts (via LIM domains) with TRAF6. Found in a complex with TRAF6, PRKCZ and SQSTM1. Interacts (via LIM
domains) SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with SQSTM1 and RB1.
Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Interacts with EIF4E, EIF2C1, EIF2C2, DCP2,
DDX6, LATS1, LATS2, EGLN1/PHD2, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM zinc-binding 2) with isoform 1 and
isoform 3 of VHL. Interacts (via LIM domains) with SNAI1 (via SNAG domain)
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal
adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the
nucleus but not nucleoli. Co-localizes with VCL in the focal adhesions. Down-regulation and/or elimination of its
expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms
of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient
prognosis
Secondary accessions: Q17RQ1 Q9BQQ9 Q9NQ47

Explore the universe of human proteins at neXtProt for LIMD1: NX_Q9UGP4

Post-translational modifications:

  • Phosphorylated during mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UGP4

  • LIMD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055055.1  
    ENSEMBL proteins: 
     ENSP00000394537   ENSP00000273317  

    Human Recombinant Protein Products: 
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    Novus Biologicals LIMD1 Proteins
    Novus Biologicals LIMD1 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LIMD1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IDA18439753
    GO:0005737cytoplasm IDA18439753
    GO:0005912adherens junction IDA--
    GO:0005925focal adhesion IDA18439753


    LIMD1 for ontologies           About GeneDecksing



    LIMD1 Antibody Products: 
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    Uscn Antibodies for LIMD1
    Search ThermoFisher Antibodies for LIMD1

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    Uscn ELISAs and CLIAs for LIMD1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LIMD1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q9UGP4

    ProtoNet protein and cluster: Q9UGP4

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved
    in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene
    transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA
    (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by
    bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a
    transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively
    regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription,
    and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast
    development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate
    adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts.
    May act as a tumor suppressor by inhibiting cell proliferation
    Induction: Down-regulated in lung cancer

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    hsa-miR-3678-3p hsa-miR-328 hsa-let-7d hsa-miR-485-3p hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-98
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMD1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    LIMD1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Limd1tm1Gdl for LIMD1
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Limd1):
     hematopoietic system  immune system  skeleton 

    LIMD1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LIMD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/34 Interacting proteins for LIMD1 (Q9UGP41, 2, 3 ENSP000002733174) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK3Q9H4222, 3, ENSP000003042264MINT-61750 I2D: score=3 STRING: ENSP00000304226
    RARAP102763, ENSP000002540664I2D: score=1 STRING: ENSP00000254066
    RPP14O950593, ENSP000002959594I2D: score=2 STRING: ENSP00000295959
    STACQ994693, ENSP000002731834I2D: score=1 STRING: ENSP00000273183
    TRAF6Q9Y4K33I2D: score=2 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0002076osteoblast development ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS10647888
    GO:0007010cytoskeleton organization IMP--


    LIMD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIMD1
    Search CenterWatch for drugs/clinical trials and news about LIMD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIMD1 gene: 
    NM_014240.2  

    Unigene Cluster for LIMD1:

    LIM domains containing 1
    Hs.193370  [show with all ESTs]
    Unigene Representative Sequence: NM_014240
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465039 ENST00000440097 ENST00000273317(uc003coq.3) ENST00000474665


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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMD1 (see all 39):
    hsa-miR-3678-3p hsa-miR-328 hsa-let-7d hsa-miR-485-3p hsa-miR-766 hsa-let-7g hsa-let-7a hsa-miR-98
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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    GenScript: all cDNA clones in your preferred vector: LIMD1 (NM_014240)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LIMD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMD1

    Additional cDNA sequence: 

    AJ132408.1 AK021508.1 AK125901.1 BC027712.2 BC117236.1 BC117238.1 M80651.1 

    11 DOTS entries:

    DT.409014  DT.91952643  DT.40268098  DT.95264356  DT.204680  DT.100760931  DT.95236580  DT.100680680 
    DT.91702365  DT.92045826  DT.95075428 

    24/84 AceView cDNA sequences (see all 84):

    BM766194 AU117429 BM764476 AA613893 AA746316 BC027712 BU155896 BM751219 
    BX501498 BI088163 BM765265 BX099207 AI866731 BE727392 BG258305 BM793357 
    BG180535 BE409173 BX419713 BI819770 AA437106 AW294379 BE727848 AJ132408 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIMD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGAAACACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See LIMD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIMD1

    SOURCE GeneReport for Unigene cluster: Hs.193370

    UniProtKB/Swiss-Prot: LIMD1_HUMAN, Q9UGP4
    Tissue specificity: Expressed in normal and breast cancer tissues (at protein level). Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LIMD1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LIMD11 LIM domains containing 1 66.61(n)
    64.72(a)
      420701  XM_418800.3  XP_418800.3 
    lizard
    (Anolis carolinensis)
    Reptilia LIMD16
    --
    51(a)
    1 ↔ 1
    GL343324.1(108030-151739)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.170312 Transcribed sequence with moderate similarity to protein more 76.93(n)    BX781131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5627931 uncharacterized LOC562793 58.07(n)
    57.76(a)
      562793  XM_686167.5  XP_691259.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG110633 ligand-dependent nuclear receptor
    interactor
    66(a)   12C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea zyx-13 LIM domain containing proteins 42(a)   II(13057045-13070542)   --


    ENSEMBL Gene Tree for LIMD1 (if available)
    TreeFam Gene Tree for LIMD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIMD1 gene
    LPP2  FBLIM12  TRIP62  AJUBA2  WTIP2  ZYX2  
    8 SIMAP similar genes for LIMD1 using alignment to 2 protein entries:     LIMD1_HUMAN (see all proteins):
    LHX8    LIMS1    WTIP    LHX6    LHX4    ZYX
    AJUBA    TRIP6

    LIMD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1703 NCBI SNPs in LIMD1 are shown (see all 1703    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487088901,2
    --45634365(+) AATGGA/CGTGGG 1 -- us2k10--------
    rs1892683231,2
    --45634400(+) AAAAAA/CCGCAT 1 -- us2k10--------
    rs1812534921,2
    --45634403(+) AAACGA/CATGTT 1 -- us2k10--------
    rs759336001,2
    C,--45634439(+) AGTTAT/GCAGAA 1 -- us2k12Minor allele frequency- G:0.08CSA WA 120
    rs1849291211,2
    --45634812(+) GGGGGC/TGCCAA 1 -- us2k10--------
    rs797910091,2
    F,--45634830(+) GGCCTG/CGTGTC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1177177691,2
    C,--45634859(+) CACTTG/CCAGAT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs2017749721,2
    --45634941(+) GCAGG-/CACAACG 1 -- us2k10--------
    rs1429726461,2
    C,--45634942(+) CAGGC-/ACAACGAG 1 -- us2k10--------
    rs1138804731,2
    C,--45634945(+) GCACAACGAG/
            
    ACTTT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for LIMD1 (45596886 - 45727830 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for LIMD1
         1 CNV: 47995

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LIMD1 for disorders           About GeneDecksing

    OMIM gene information: 604543    OMIM disorders: --

    9 diseases for LIMD1:    About MalaCards
    squamous cell carcinoma    pandas    lung cancer    breast cancer
    carcinoma    pancreatic cancer    breast carcinoma    hypoxia
    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: LIMD1 (1 document)

    Export disorders for LIMD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIMD1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with LIMD1)
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    1. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 10647888)1, 2, 3 Kiss H.... Dumanski J.P. (1999)
    2. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. (PubMed id 15542589)1, 2, 9 Sharp T.V....Boshoff C. (2004)
    3. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    4. Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival. (PubMed id 18712738)1, 2 Spendlove I....Sharp T.V. (2008)
    5. Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers. (PubMed id 18439753)1, 2 Huggins C.J. and Andrulis I.L. (2008)
    6. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274)1, 2 Feng Y. and Longmore G.D. (2005)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. (PubMed id 11352561)1, 2 Kiss H....Dumanski J.P. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8994 HGNC: 6612 AceView: LIMD1 Ensembl:ENSG00000144791 euGenes: HUgn8994
    ECgene: LIMD1 H-InvDB: LIMD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIMD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LIMD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIMD1 gene:
    Search GeneIP for patents involving LIMD1

    GeneCards and IP:
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