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Aliases for LIMCH1 Gene

Aliases for LIMCH1 Gene

  • LIM And Calponin Homology Domains 1 2 3
  • KIAA1102 4
  • LIMCH1A 3
  • LMO7B 3

External Ids for LIMCH1 Gene

Previous GeneCards Identifiers for LIMCH1 Gene

  • GC04P041057
  • GC04P040684

Summaries for LIMCH1 Gene

GeneCards Summary for LIMCH1 Gene

LIMCH1 (LIM And Calponin Homology Domains 1) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is LMO7.

Gene Wiki entry for LIMCH1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMCH1 Gene

Genomics for LIMCH1 Gene

Regulatory Elements for LIMCH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LIMCH1 Gene

Chromosome:
4
Start:
41,359,607 bp from pter
End:
41,700,044 bp from pter
Size:
340,438 bases
Orientation:
Plus strand

Genomic View for LIMCH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIMCH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMCH1 Gene

Proteins for LIMCH1 Gene

  • Protein details for LIMCH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPQ0-LIMC1_HUMAN
    Recommended name:
    LIM and calponin homology domains-containing protein 1
    Protein Accession:
    Q9UPQ0
    Secondary Accessions:
    • A8MXC3
    • E9PHM7
    • Q503B5
    • Q5CZB1
    • Q5CZB6
    • Q5H9S8
    • Q68E07
    • Q6PJ44
    • Q7Z3G5
    • Q8N3S9
    • Q8N6M2

    Protein attributes for LIMCH1 Gene

    Size:
    1083 amino acids
    Molecular mass:
    121867 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83054.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LIMCH1 Gene

neXtProt entry for LIMCH1 Gene

Proteomics data for LIMCH1 Gene at MOPED

Post-translational modifications for LIMCH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for LIMCH1 Gene

Domains & Families for LIMCH1 Gene

Suggested Antigen Peptide Sequences for LIMCH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPQ0

UniProtKB/Swiss-Prot:

LIMC1_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the LIMCH1 family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
Family:
  • Belongs to the LIMCH1 family.
genes like me logo Genes that share domains with LIMCH1: view

No data available for Gene Families for LIMCH1 Gene

Function for LIMCH1 Gene

Gene Ontology (GO) - Molecular Function for LIMCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LIMCH1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIMCH1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for LIMCH1 Gene

Localization for LIMCH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIMCH1 Gene COMPARTMENTS Subcellular localization image for LIMCH1 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LIMCH1 Gene

Pathways & Interactions for LIMCH1 Gene

SuperPathways for LIMCH1 Gene

No Data Available

Interacting Proteins for LIMCH1 Gene

Gene Ontology (GO) - Biological Process for LIMCH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031032 actomyosin structure organization IEA --
genes like me logo Genes that share ontologies with LIMCH1: view

No data available for Pathways by source and SIGNOR curated interactions for LIMCH1 Gene

Drugs & Compounds for LIMCH1 Gene

No Compound Related Data Available

Transcripts for LIMCH1 Gene

Unigene Clusters for LIMCH1 Gene

LIM and calponin homology domains 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIMCH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIMCH1 Gene

No ASD Table

Relevant External Links for LIMCH1 Gene

GeneLoc Exon Structure for
LIMCH1
ECgene alternative splicing isoforms for
LIMCH1

Expression for LIMCH1 Gene

mRNA expression in normal human tissues for LIMCH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIMCH1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for LIMCH1 Gene

This gene is overexpressed in Thyroid (16.4), Plasma (7.1), and Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LIMCH1 Gene



SOURCE GeneReport for Unigene cluster for LIMCH1 Gene Hs.335163

genes like me logo Genes that share expression patterns with LIMCH1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for LIMCH1 Gene

Orthologs for LIMCH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LIMCH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LIMCH1 35
  • 90.52 (n)
  • 91.94 (a)
LIMCH1 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIMCH1 35
  • 87.32 (n)
  • 90.21 (a)
LIMCH1 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Limch1 35
  • 86.08 (n)
  • 87.1 (a)
Limch1 16
Limch1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LIMCH1 35
  • 99.38 (n)
  • 99.45 (a)
LIMCH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Limch1 35
  • 85.64 (n)
  • 88.17 (a)
oppossum
(Monodelphis domestica)
Mammalia LIMCH1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIMCH1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIMCH1 35
  • 70.94 (n)
  • 70.21 (a)
LIMCH1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LIMCH1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia limch1 35
  • 63.19 (n)
  • 60.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13843 35
zebrafish
(Danio rerio)
Actinopterygii limch1b 35
  • 58.64 (n)
  • 57.4 (a)
wufk03g12 35
limch1a 36
  • 18 (a)
OneToMany
limch1b 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43427 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lim-8 36
  • 10 (a)
OneToMany
Species with no ortholog for LIMCH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LIMCH1 Gene

ENSEMBL:
Gene Tree for LIMCH1 (if available)
TreeFam:
Gene Tree for LIMCH1 (if available)

Paralogs for LIMCH1 Gene

Paralogs for LIMCH1 Gene

genes like me logo Genes that share paralogs with LIMCH1: view

Variants for LIMCH1 Gene

Sequence variations from dbSNP and Humsavar for LIMCH1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_033105 -

Structural Variations from Database of Genomic Variants (DGV) for LIMCH1 Gene

Variant ID Type Subtype PubMed ID
esv2430788 CNV Deletion 19546169
nsv471807 CNV Loss 16327809
esv2017028 CNV Deletion 18987734
nsv524341 CNV Loss 19592680
nsv441871 CNV CNV 18776908
esv2667299 CNV Deletion 23128226
esv27465 CNV Loss 19812545
esv2727482 CNV Deletion 23290073
esv2727483 CNV Deletion 23290073
nsv293326 CNV Loss 16902084
esv2727484 CNV Deletion 23290073
esv2482453 CNV Deletion 19546169
esv2727486 CNV Deletion 23290073
esv2002334 CNV Deletion 18987734
esv2727487 CNV Deletion 23290073
esv3112 CNV Deletion 18987735
esv1310867 CNV Deletion 17803354
nsv290711 CNV Loss 16902084
esv2727488 CNV Deletion 23290073
nsv441872 CNV CNV 18776908
nsv4309 CNV Insertion 18451855
nsv829916 CNV Loss 17160897
esv275374 CNV Loss 21479260
esv275061 CNV Loss 21479260
esv273514 CNV Insertion 20981092

Variation tolerance for LIMCH1 Gene

Residual Variation Intolerance Score: 46.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.13; 96.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIMCH1 Gene

HapMap Linkage Disequilibrium report
LIMCH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMCH1 Gene

Disorders for LIMCH1 Gene

Relevant External Links for LIMCH1

Genetic Association Database (GAD)
LIMCH1
Human Genome Epidemiology (HuGE) Navigator
LIMCH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIMCH1
genes like me logo Genes that share disorders with LIMCH1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIMCH1 Gene

Publications for LIMCH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. (PMID: 25199915) Broer L. … Murabito J.M. (J. Gerontol. A Biol. Sci. Med. Sci. 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for LIMCH1 Gene

Sources for LIMCH1 Gene

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