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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LIMA1 Gene

protein-coding GIFtS: 50
GCID: GC12M050569

LIM domain and actin binding 1

Explore 6 diseases affiliated with
LIMA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
LIM Domain And Actin Binding 1¹ ²		Epithelial Protein Lost In Neoplasm Beta²
EPLIN¹ ² ³ ⁵		LIM Domain And Actin-Binding Protein 1²
SREBP3² ³ ⁵		Sterol Regulatory Element Binding Protein 3²
1110021C24Rik²		Epithelial Protein Lost In Neoplasm³

External Ids:	HGNC: 24636¹	Entrez Gene: 51474²	Ensembl: ENSG00000050405⁷	OMIM: 608364⁵	UniProtKB: Q9UHB6³

Export aliases for LIMA1 gene to outside databases

Previous GC identifers: GC12M048856 GC12M047604

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIMA1:

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links

filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants

encoding different isoforms have been described for this gene, and expression of some of the variants maybe

independently regulated. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6

Function: Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits

membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and

reduces formation of branched filaments

Gene Wiki entry for LIMA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LIMA1 gene promoter:
AML1a SREBP-1c Gfi-1 SREBP-1b HEN1 SREBP-1a POU2F1 POU2F1a Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIMA1 promoter sequence

Search SABiosciences Chromatin IP Primers for LIMA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12

LIMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMA1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M050569: view genomic region (about GC identifiers)

Start:	50,569,563 bp from pter	End:	50,677,353 bp from pter
Size:	107,791 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6 (See protein sequence)

Recommended Name: LIM domain and actin-binding protein 1

Size: 759 amino acids; 85226 Da

Subcellular location: Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein

co-localizes with actin stress fibers and focal adhesion plaques

Sequence caution: Sequence=AAG17267.1; Type=Frameshift; Positions=365, 662; Sequence=BAA91120.1; Type=Frameshift;

Positions=697;

1 PDB 3D structure from and Proteopedia for LIMA1:

2D8Y (3D)

Secondary accessions: B2RB09 Q2TAN7 Q9BVF2 Q9H8J1 Q9HBN5 Q9NX96 Q9NXC3 Q9NXU6 Q9P0H8 Q9UHB5

Alternative promoter usage, Alternative splicing: 4 isoforms: Q9UHB6-1 Q9UHB6-2 Q9UHB6-3 Q9UHB6-4 (Produced by alternative splicing. Contains a phosphoserine at position 343)

Explore the universe of human proteins at neXtProt for LIMA1: NX_Q9UHB6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UHB6

LIMA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001107018.1 NP_001107019.1 NP_001230704.1 NP_057441.1

ENSEMBL proteins:

ENSP00000448463 ENSP00000448706 ENSP00000450266 ENSP00000378400 ENSP00000340184

ENSP00000448779 ENSP00000450087 ENSP00000448411 ENSP00000447720 ENSP00000447975

ENSP00000449890

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	Uscn Proteins for LIMA1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	10618726
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0005925	focal adhesion	IDA	10618726
GO:0015629	actin cytoskeleton	IDA	--

LIMA1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LIMA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LIMA1 for domains About GeneDecksing

1 InterPro domain/family:

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry Q9UHB6

ProtoNet protein and cluster: Q9UHB6

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6

Domain: Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers

and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus

Similarity: Contains 1 LIM zinc-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6

Function: Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits

membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and

reduces formation of branched filaments

Induction: Down-regulated in some cancer cell lines. Isoform Alpha is induced by serum. Isoform Beta is constitutively

expressed

miRNA Products:		OriGene 3'-UTR Clone (see all 3): LIMA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIMA1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMA1 (see all 17):
		hsa-miR-106a hsa-miR-938 hsa-miR-216b hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-548c-3p hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: LIMA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMA1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003785	actin monomer binding	IDA	12566430
GO:0008270	zinc ion binding	IEA	--
GO:0051015	actin filament binding	IDA	12566430

LIMA1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Stabilization and expansion of the E-cadherin adherens junction

Stabilization and expansion of the E-cadherin adherens junction

1.00

1 BioSystems Pathway for LIMA1

Stabilization and expansion of the E-cadherin adherens junction

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LIMA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/21 Interacting proteins for LIMA1 (Q9UHB6^{2, 3} ENSP00000378400⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K3	Q99759²^,³	MINT-48519 I2D: score=1
RIPK3	Q9Y572²^,³	MINT-49153 I2D: score=1
YWHAZ	P63104²^,³	MINT-3295953 I2D: score=1
ESR2	Q92731³, ENSP00000343925⁴	I2D: score=1 STRING: ENSP00000343925
SVIL	O95425³, ENSP00000348128⁴	I2D: score=1 STRING: ENSP00000348128

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030835	negative regulation of actin filament depolymerization	IDA	12566430
GO:0031529	ruffle organization	IDA	12566430
GO:0051017	actin filament bundle assembly	IDA	12566430

LIMA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LIMA1
Search CenterWatch for drugs/clinical trials and news about LIMA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LIMA1 gene (4 alternative transcripts):

NM_001113546.1 NM_001113547.1 NM_001243775.1 NM_016357.4

Unigene Cluster for LIMA1:

LIM domain and actin binding 1

Hs.525419 [show with all ESTs]

Unigene Representative Sequence: NM_001113546

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000552491 ENST00000547825(uc001rwg.4) ENST00000552823 ENST00000394943(uc001rwh.4)

ENST00000341247(uc001rwj.4 uc001rwk.4 uc010sms.2 uc010smr.2)

ENST00000552783(uc001rwi.4) ENST00000552909 ENST00000552720 ENST00000549064

ENST00000552338 ENST00000552008 ENST00000552045 ENST00000551486 ENST00000550611

ENST00000549681 ENST00000551691 ENST00000550592

miRNA Products:		OriGene 3'-UTR Clone (see all 3): LIMA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LIMA1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate LIMA1 (see all 17):
		hsa-miR-106a hsa-miR-938 hsa-miR-216b hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-548c-3p hsa-miR-17

		SwitchGear 3'UTR luciferase reporter plasmid: LIMA1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMA1

Additional cDNA sequence:

AB209512.1 AF157325.1 AF198454.1 AF198455.1 AF218025.1 AK000057.1 AK000335.1 AK000372.1

AK023649.1 AK096172.1 AK222971.1 AK297766.1 AK314447.1 AL136911.1 BC001247.1 BC010664.1

BC110815.1 BC136763.1 BC144402.1 BC144403.1

15 DOTS entries:

DT.100819043 DT.92456287 DT.86845452 DT.100819042 DT.95245153 DT.121130288 DT.92051769 DT.95196924

DT.121130266 DT.40189444 DT.75175098 DT.100819045 DT.102826445 DT.75147778 DT.91820351

24/359 AceView cDNA sequences (see all 359):

CA447584 AA709389 AA732369 AA772616 CA413573 AF198455 AA552115 AW051405

AI095661 AA724868 AA553659 BQ694787 AI241322 N27847 AK000335 CN483889

BF197289 AI867204 CB130547 AI081288 BC001247 AI806874 AA635572 AA593109

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LIMA1 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·	14c	·	14d	·
SP1:							-						-		-																-				-						-
SP2:							-						-		-																-				-						-
SP3:																															-				-						-
SP4:																															-				-						-
SP5:													-		-

ExUns:	14e
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LIMA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LIMA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGTAATT

About this image
See LIMA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LIMA1

SOURCE GeneReport for Unigene cluster: Hs.525419

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6

Tissue specificity: Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in

lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed

generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal

oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for LIMA1 gene from 9/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lima1^{1 , 5}	LIM domain and actin binding 1^{1, 5}	80.1(n)¹ 76.73(a)¹		15 (56.13 cM)⁵ 65970¹ NM_001113545.1¹ NP_001107017.1¹ 99778470⁵
chicken (Gallus gallus)	Aves	LIMA1¹	LIM domain and actin binding 1	66.8(n) 60.08(a)		426878 XM_424485.2 XP_424485.2
lizard (Anolis carolinensis)	Reptilia	LIMA1⁶	--	53(a)	1 ↔ 1	2(91497040-91564259)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24780²	Xenopus laevis transcribed sequence with weak similarity more	75.9(n)		CA972760.1
zebrafish (Danio rerio)	Actinopterygii	AF307846.1²	--	76.01(n)		64000 AF307846.1
fruit fly (Drosophila melanogaster)	Insecta	CG33521⁶	--	7(a)	possible ortholog	4(1206399-1213320)
worm (Caenorhabditis elegans)	Secernentea	tag-273⁶	Temporarily Assigned Gene name family member (tag-...	8(a)	possible ortholog	IV(14487059-14505139)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G39900⁶ AT3G55770⁶ (see all 6)	LIM domain-containing protein GATA type zinc finger transcription factor-like pr... (see all 6)	22(a) 20(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2(16658656-16660437) 3(20703222-20705320)
rice (Oryza sativa)	Liliopsida	-- -- (see all 6)	OsLIM - LIM domain protein, putative actin-binding... OsWLIM2 - LIM domain protein, putative actin-bindi... (see all 6)	3(a) 25(a) (see all 6)	many ↔ many many ↔ many (see all 6)	6(7132790-7139004) 3(8796786-8798774)

ENSEMBL Gene Tree for LIMA1 (if available)
TreeFam Gene Tree for LIMA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LIMA1 gene

LIMD2²

1 SIMAP similar gene for LIMA1 using alignment to 8 protein entries: LIMA1_HUMAN (see all proteins):

LIMD2

LIMA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75806702^1,2		--	47602945(+)	`CAACAA/GATGTA`	4	--	ut3¹		2		CSA WA	120
rs9588^1,2	C	--	47603088(+)	`AATTAG/TTGTCT`	4	--	ut3¹ ese³		2		MN NA	186
rs76020374^1,2		--	47603196(+)	`TTGCTC/GTAACA`	4	--	ut3¹		0	--	--	--	--
rs74090094^1,2	C,F,	--	47603281(+)	`TATCAC/TCAGAA`	4	--	ut3¹		3		WA CSA	122
rs3184122^1,2	C,F,A,H,	--	47603310(-)	`TTTACT/CGTACT`	4	--	ut3¹ ese³		27		MN NA NS EA WA	2856
rs3794312^1,2	C,H,	--	47603597(+)	`CTGTGC/TCCTTT`	4	--	ut3¹ ese³		4		NS EA	420
rs78593506^1,2	F,	--	47608144(+)	`AGAACT/AAATGA`	4	--	int¹		1		WA	118
rs12424408^1,2	C,H	--	47608278(+)	`GCTCAG/AAAAGG`	4	--	int¹ trp³		5		NS EA NA	502
rs78114577^1,2	F,	--	47608451(+)	`GCAACA/GTAGAG`	4	--	int¹		1		WA	118
rs111451100^1,2	C,	--	47609326(+)	`GGTCGG/CGGGGG`	4	--	int¹		2		NA	122

HapMap Linkage Disequilibrium report for LIMA1 (50569563 - 50677353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LIMA1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LIMA1 for disorders           About GeneDecksing

OMIM gene information: 608364    OMIM disorders: --

6 diseases for LIMA1:    About MalaCards

breast carcinoma prostate cancer breast cancer adenoma

carcinoma prostatitis

2 Novoseek disease relationships for LIMA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	17.5	3	10618726 (1), 11179679 (1)
tumors	4.24	1	12566430 (1)

Export disorders for LIMA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LIMA1 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with LIMA1)

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world of online information

EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. (PubMed id 12566430)^{1, 2, 3, 9} Maul R.S.... Chang D.D. (2003)
EPLIN, epithelial protein lost in neoplasm. (PubMed id 10618726)^{1, 2, 3, 9} Maul R.S. and Chang D.D. (1999)
Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms. (PubMed id 10806352)^{1, 2, 3, 9} Chen S.... Chang D.D. (2000)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)^{1, 2} Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51474	HGNC: 24636	AceView: EPLIN	Ensembl:ENSG00000050405	euGenes: HUgn51474
ECgene: LIMA1	H-InvDB: LIMA1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LIMA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LIMA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LIMA1 gene:
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GeneCards and IP:
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LIM domain and actin binding 1

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LIM domain and actin binding 1

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