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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LIMA1 Gene

protein-coding   GIFtS: 54
GCID: GC12M050569

LIM Domain And Actin Binding 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Domain And Actin Binding 11 2     1110021C24Rik2
EPLIN2 3 5     LIM Domain And Actin-Binding Protein 12
SREBP32 3 5     Sterol Regulatory Element Binding Protein 32
Epithelial Protein Lost In Neoplasm Beta1 2     Epithelial Protein Lost In Neoplasm3

External Ids:    HGNC: 246361   Entrez Gene: 514742   Ensembl: ENSG000000504057   OMIM: 6083645   UniProtKB: Q9UHB63   

Export aliases for LIMA1 gene to outside databases

Previous GC identifers: GC12M048856 GC12M047604


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LIMA1 Gene:
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links
filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene, and expression of some of the variants maybe
independently regulated. (provided by RefSeq, Aug 2011)

GeneCards Summary for LIMA1 Gene: 
LIMA1 (LIM domain and actin binding 1) is a protein-coding gene. Diseases associated with LIMA1 include colon adenocarcinoma, and adenoma. GO annotations related to this gene include actin monomer binding and actin filament binding. An important paralog of this gene is LIMD2.

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6
Function: Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits
membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation
and reduces formation of branched filaments

Gene Wiki entry for LIMA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LIMA1 gene promoter:
         AML1a   SREBP-1c   Gfi-1   SREBP-1b   HEN1   SREBP-1a   POU2F1   POU2F1a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LIMA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LIMA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LIMA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

LIMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIMA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050569:  view genomic region     (about GC identifiers)

Start:
50,569,563 bp from pter      End:
50,677,353 bp from pter
Size:
107,791 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6 (See protein sequence)
Recommended Name: LIM domain and actin-binding protein 1  
Size: 759 amino acids; 85226 Da
Subcellular location: Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal
protein co-localizes with actin stress fibers and focal adhesion plaques
Sequence caution: Sequence=AAG17267.1; Type=Frameshift; Positions=365, 662; Sequence=BAA91120.1; Type=Frameshift;
Positions=697;
1 PDB 3D structure from and Proteopedia for LIMA1:
2D8Y (3D)    
Secondary accessions: B2RB09 Q2TAN7 Q9BVF2 Q9H8J1 Q9HBN5 Q9NX96 Q9NXC3 Q9NXU6 Q9P0H8 Q9UHB5
Alternative promoter usage, Alternative splicing: 4 isoforms:  Q9UHB6-1   Q9UHB6-2   Q9UHB6-3   Q9UHB6-4   (Produced by alternative splicing. Contains a phosphoserine at position 343)

Explore the universe of human proteins at neXtProt for LIMA1: NX_Q9UHB6

Explore proteomics data for LIMA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UHB6

  • LIMA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LIMA1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001107018.1  NP_001107019.1  NP_001230704.1  NP_057441.1  

    ENSEMBL proteins: 
     ENSP00000448463   ENSP00000448706   ENSP00000450266   ENSP00000378400   ENSP00000340184  
     ENSP00000448779   ENSP00000450087   ENSP00000448411   ENSP00000447975   ENSP00000449890  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for LIMA1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA10618726
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0005925focal adhesion IDA10618726
    GO:0015629actin cytoskeleton IDA--

    LIMA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q9UHB6

    ProtoNet protein and cluster: Q9UHB6

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6
    Domain: Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin
    monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus
    Similarity: Contains 1 LIM zinc-binding domain


    LIMA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIMA1_HUMAN, Q9UHB6
    Function: Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits
    membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation
    and reduces formation of branched filaments
    Induction: Down-regulated in some cancer cell lines. Isoform Alpha is induced by serum. Isoform Beta is
    constitutively expressed

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003785actin monomer binding IDA12566430
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0051015actin filament binding IDA12566430
         
    LIMA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Lima1 (no phenotypes)

    LIMA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LIMA1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LIMA1 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LIMA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction


    1 BioSystems Pathway for LIMA1
        Stabilization and expansion of the E-cadherin adherens junction


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LIMA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/21 Interacting proteins for LIMA1 (Q9UHB62, 3 ENSP000003784004) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48519 I2D: score=1 
    RIPK3Q9Y5722, 3MINT-49153 I2D: score=1 
    YWHAZP631042, 3MINT-3295953 I2D: score=1 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SVILO954253, ENSP000003481284I2D: score=1 STRING: ENSP00000348128
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030835negative regulation of actin filament depolymerization IDA12566430
    GO:0031529ruffle organization IDA12566430
    GO:0051017actin filament bundle assembly IDA12566430

    LIMA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LIMA1

    Search CenterWatch for drugs/clinical trials and news about LIMA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LIMA1 gene (4 alternative transcripts): 
    NM_001113546.1  NM_001113547.1  NM_001243775.1  NM_016357.4  

    Unigene Cluster for LIMA1:

    LIM domain and actin binding 1
    Hs.525419  [show with all ESTs]
    Unigene Representative Sequence: NM_001113546
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552491 ENST00000547825(uc001rwg.4) ENST00000552823 ENST00000394943(uc001rwh.4)
    ENST00000341247(uc001rwj.4 uc001rwk.4 uc010sms.2 uc010smr.2)
    ENST00000552783(uc001rwi.4) ENST00000552909 ENST00000552720 ENST00000549064
    ENST00000552338 ENST00000552008 ENST00000552045 ENST00000551486 ENST00000550611
    ENST00000551691 ENST00000550592
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LIMA1

    Additional mRNA sequence: 

    AB209512.1 AF157325.1 AF198454.1 AF198455.1 AF218025.1 AK000057.1 AK000335.1 AK000372.1 
    AK023649.1 AK096172.1 AK222971.1 AK297766.1 AK314447.1 AL136911.1 BC001247.1 BC010664.1 
    BC110815.1 BC136763.1 BC144402.1 BC144403.1 

    15 DOTS entries:

    DT.100819043  DT.92456287  DT.86845452  DT.100819042  DT.95245153  DT.121130288  DT.92051769  DT.95196924 
    DT.121130266  DT.40189444  DT.75175098  DT.100819045  DT.102826445  DT.75147778  DT.91820351 

    24/359 AceView cDNA sequences (see all 359):

    AW137953 AI082103 BF528886 CN483889 AI473775 BQ694787 AA905326 AI241322 
    AK000335 BM909158 AI538176 BU622584 BU527038 AA553659 CA412726 AW194478 
    BF512646 AI095661 BE042640 AI806874 AA852558 AF198454 BE463563 NM_016357 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LIMA1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d ·
    SP1:                    -                 -     -                                               -           -                 -                                 
    SP2:                    -                 -     -                                               -           -                 -                                 
    SP3:                                                                                            -           -                 -                                 
    SP4:                                                                                            -           -                 -                                 
    SP5:                                      -     -                                                                                                               

    ExUns: 14e
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for LIMA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LIMA1 expression in normal human tissues (normalized intensities)      LIMA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGTAATT
    LIMA1 Expression
    About this image


    LIMA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             duodenum   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             bronchus ; respiratory epithelial cells   
             bronchoalveolar lavage cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See LIMA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LIMA1

    SOURCE GeneReport for Unigene cluster: Hs.525419

    UniProtKB/Swiss-Prot: LIMA1_HUMAN, Q9UHB6
    Tissue specificity: Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also
    detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes.
    Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary
    gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts.
    Not detectable in myocardium

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIMA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LIMA1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lima11 , 5 LIM domain and actin binding 11, 5 80.1(n)1
    76.73(a)1
      15 (56.13 cM)5
    659701  NM_001113545.11  NP_001107017.11 
     997784705 
    chicken
    (Gallus gallus)
    Aves LIMA11 LIM domain and actin binding 1 66.8(n)
    60.08(a)
      426878  XM_424485.2  XP_424485.2 
    lizard
    (Anolis carolinensis)
    Reptilia LIMA16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    2(91497040-91566020)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247802 Xenopus laevis transcribed sequence with weak similarity more 75.9(n)    CA972760.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF307846.12   -- 76.01(n)   64000  AF307846.1 


    ENSEMBL Gene Tree for LIMA1 (if available)
    TreeFam Gene Tree for LIMA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LIMA1 gene
    LIMD22  
    1 SIMAP similar gene for LIMA1 using alignment to 7 protein entries:     LIMA1_HUMAN (see all proteins):
    LIMD2

    LIMA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2025 SNPs in LIMA1 are shown (see all 2025)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710835201,2
    C--47617510(+) TTTTT-/T/TTTT
            
    GTACT
    4 -- int11NA 2
    rs57981311,2
    C--47619948(+) TGTGTGC/-GCGCG 4 -- int11Minor allele frequency- -:0.50NA 2
    rs30736231,2
    C,H--47619949(-) cgcgcA/Gcacac 4 -- int10--------
    rs283911721,2
    C,F--47619949(+) GTGTGC/TGCGCG 4 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs675766111,2
    C--47620515(+) ATATGAT/-ATATA 4 -- int11Minor allele frequency- -:0.50NA 2
    rs111693111,2
    --47620612(+) TATATA/TTTTTT 4 -- int1 trp30--------
    rs340670711,2
    C--47620937(+) TATAT-/A/TTATTT 4 -- int10--------
    rs128167971,2
    C--47620941(+) tatatT/Attttt 4 -- int14Minor allele frequency- A:0.12NA 8
    rs1118260551,2
    C--47620941(+) TATAT-/ATTTTT 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs347536401,2
    C--47635936(+) CTTTC-/TTTTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for LIMA1 (50569563 - 50677353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LIMA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745870CNV Deletion23290073
    esv2745869CNV Deletion23290073
    esv267880CNV Insertion20981092
    nsv702CNV Loss18451855
    nsv899075CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608364    OMIM disorders: --

    7 diseases for LIMA1:    About MalaCards
    colon adenocarcinoma    adenoma    endotheliitis    prostatitis
    prostate cancer    adenocarcinoma    breast cancer


    LIMA1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for LIMA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 17.5 3 10618726 (1), 11179679 (1)
    tumors 4.24 1 12566430 (1)

    Genetic Association Database (GAD): LIMA1

    Export disorders for LIMA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LIMA1 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with LIMA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. (PubMed id 12566430)1, 2, 3, 9 Maul R.S.... Chang D.D. (2003)
    2. EPLIN, epithelial protein lost in neoplasm. (PubMed id 10618726)1, 2, 3, 9 Maul R.S. and Chang D.D. (1999)
    3. Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms. (PubMed id 10806352)1, 2, 3, 9 Chen S.... Chang D.D. (2000)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1, 2 Simpson J.C.... Wiemann S. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51474 HGNC: 24636 AceView: EPLIN Ensembl:ENSG00000050405 euGenes: HUgn51474
    ECgene: LIMA1 H-InvDB: LIMA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LIMA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LIMA1 gene:
    Search GeneIP for patents involving LIMA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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