Aliases for LIMA1 Gene
External Ids for LIMA1 Gene
Previous GeneCards Identifiers for LIMA1 Gene
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]
GeneCards Summary for LIMA1 Gene
LIMA1 (LIM Domain And Actin Binding 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Stabilization and expansion of the E-cadherin adherens junction. Gene Ontology (GO) annotations related to this gene include actin filament binding and actin monomer binding. An important paralog of this gene is LIMD2.
UniProtKB/Swiss-Prot for LIMA1 Gene
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.