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Aliases for LIMA1 Gene

Aliases for LIMA1 Gene

  • LIM Domain And Actin Binding 1 2 3 5
  • Epithelial Protein Lost In Neoplasm Beta 2 3
  • SREBP3 3 4
  • EPLIN 3 4
  • Sterol Regulatory Element Binding Protein 3 3
  • LIM Domain And Actin-Binding Protein 1 3
  • Epithelial Protein Lost In Neoplasm 4
  • 1110021C24Rik 3

External Ids for LIMA1 Gene

Previous GeneCards Identifiers for LIMA1 Gene

  • GC12M048856
  • GC12M050569
  • GC12M047604

Summaries for LIMA1 Gene

Entrez Gene Summary for LIMA1 Gene

  • This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

GeneCards Summary for LIMA1 Gene

LIMA1 (LIM Domain And Actin Binding 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include actin filament binding and actin monomer binding. An important paralog of this gene is LIMD2.

UniProtKB/Swiss-Prot for LIMA1 Gene

  • Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.

Gene Wiki entry for LIMA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIMA1 Gene

Genomics for LIMA1 Gene

Regulatory Elements for LIMA1 Gene

Enhancers for LIMA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G049661 2 FANTOM5 Ensembl ENCODE dbSUPER 33.2 +619.8 619803 4.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF302 ZNF143 DDX23 LOC390314 KANSL2 LIMA1 CCNT1 ENSG00000257298 FMNL3 LOC101927267 MCRS1 BCDIN3D-AS1
GH12G050612 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -334.2 -334232 10.4 PKNOX1 ATF1 ZNF133 SIN3A GLI4 FEZF1 ZNF121 FOS ZNF263 YY2 LIMA1 ATF1 ENSG00000257298 TFCP2 DIP2B FAM186A LARP4 GC12P050634
GH12G050399 1.2 ENCODE 42.3 -118.3 -118313 4.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 TBX21 ZNF610 ZNF585B LIMA1 ATF1 CERS5 ENSG00000257298 CSRNP2 LOC100422296 BCDIN3D PRPF40B RNU6-1093P COX14
GH12G050056 1.3 ENCODE dbSUPER 33.3 +226.1 226100 1.1 ZNF493 ZNF133 ARID4B SIN3A GLI4 ZNF2 GLIS2 ZNF302 ZNF416 ZNF207 LIMA1 ATF1 ENSG00000257298 CERS5 LOC101927267 PRPF40B BCDIN3D LOC100422296 ENSG00000257964 C1QL4
GH12G051019 1.7 Ensembl ENCODE dbSUPER 24.5 -741.0 -740995 11.1 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SLC11A2 ATF1 ENSG00000257298 LIMA1 HNRNPA3P10 LETMD1 TFCP2 CSRNP2 ENSG00000272368 RNU6-87P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LIMA1 on UCSC Golden Path with GeneCards custom track

Promoters for LIMA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051756 169 1600 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 SP3 SP5

Genomic Location for LIMA1 Gene

Chromosome:
12
Start:
50,175,780 bp from pter
End:
50,283,570 bp from pter
Size:
107,791 bases
Orientation:
Minus strand

Genomic View for LIMA1 Gene

Genes around LIMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIMA1 Gene

Proteins for LIMA1 Gene

  • Protein details for LIMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHB6-LIMA1_HUMAN
    Recommended name:
    LIM domain and actin-binding protein 1
    Protein Accession:
    Q9UHB6
    Secondary Accessions:
    • B2RB09
    • Q2TAN7
    • Q59FE8
    • Q9BVF2
    • Q9H8J1
    • Q9HBN5
    • Q9NX96
    • Q9NXC3
    • Q9NXU6
    • Q9P0H8
    • Q9UHB5

    Protein attributes for LIMA1 Gene

    Size:
    759 amino acids
    Molecular mass:
    85226 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG17267.1; Type=Frameshift; Positions=365, 662; Evidence={ECO:0000305}; Sequence=BAA91120.1; Type=Frameshift; Positions=697; Evidence={ECO:0000305}; Sequence=BAD92749.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LIMA1 Gene

    Alternative splice isoforms for LIMA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIMA1 Gene

Post-translational modifications for LIMA1 Gene

  • Ubiquitination at posLast=2121, posLast=7575, and isoforms=3, 4, 5, 2462
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LIMA1 (eplin)
  • Abcam antibodies for LIMA1
  • Santa Cruz Biotechnology (SCBT) Antibodies for LIMA1

No data available for DME Specific Peptides for LIMA1 Gene

Domains & Families for LIMA1 Gene

Gene Families for LIMA1 Gene

Protein Domains for LIMA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LIMA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHB6

UniProtKB/Swiss-Prot:

LIMA1_HUMAN :
  • Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
Domain:
  • Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus.
genes like me logo Genes that share domains with LIMA1: view

Function for LIMA1 Gene

Molecular function for LIMA1 Gene

UniProtKB/Swiss-Prot Function:
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.
UniProtKB/Swiss-Prot Induction:
Down-regulated in some cancer cell lines. Isoform Alpha is induced by serum. Isoform Beta is constitutively expressed.

Gene Ontology (GO) - Molecular Function for LIMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0003785 actin monomer binding IDA 12566430
GO:0005515 protein binding IPI 20309963
GO:0008270 zinc ion binding IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with LIMA1: view

Phenotypes for LIMA1 Gene

MGI mutant phenotypes for LIMA1:
inferred from 1 alleles
GenomeRNAi human phenotypes for LIMA1:
genes like me logo Genes that share phenotypes with LIMA1: view

Animal Models for LIMA1 Gene

MGI Knock Outs for LIMA1:

Animal Model Products

CRISPR Products

miRNA for LIMA1 Gene

miRTarBase miRNAs that target LIMA1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LIMA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LIMA1 Gene

Localization for LIMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIMA1 Gene

Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LIMA1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for LIMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 10618726
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005903 brush border IEA --
GO:0005925 focal adhesion IDA,IEA 10618726
genes like me logo Genes that share ontologies with LIMA1: view

Pathways & Interactions for LIMA1 Gene

genes like me logo Genes that share pathways with LIMA1: view

Pathways by source for LIMA1 Gene

1 Cell Signaling Technology pathway for LIMA1 Gene

Gene Ontology (GO) - Biological Process for LIMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030835 negative regulation of actin filament depolymerization IDA,IEA 12566430
GO:0031529 ruffle organization IDA 12566430
GO:0051017 actin filament bundle assembly IEA,IDA 12566430
genes like me logo Genes that share ontologies with LIMA1: view

No data available for SIGNOR curated interactions for LIMA1 Gene

Drugs & Compounds for LIMA1 Gene

No Compound Related Data Available

Transcripts for LIMA1 Gene

Unigene Clusters for LIMA1 Gene

LIM domain and actin binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LIMA1

Alternative Splicing Database (ASD) splice patterns (SP) for LIMA1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: - -
SP8: - - - -
SP9:
SP10: -

ExUns: 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for LIMA1 Gene

GeneLoc Exon Structure for
LIMA1
ECgene alternative splicing isoforms for
LIMA1

Expression for LIMA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LIMA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LIMA1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.8), Bone marrow stromal cell (9.3), and Nasal epithelium (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LIMA1 Gene



Protein tissue co-expression partners for LIMA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LIMA1 Gene:

LIMA1

SOURCE GeneReport for Unigene cluster for LIMA1 Gene:

Hs.525419

mRNA Expression by UniProt/SwissProt for LIMA1 Gene:

Q9UHB6-LIMA1_HUMAN
Tissue specificity: Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.

Evidence on tissue expression from TISSUES for LIMA1 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Liver(4.3)
  • Blood(4.1)
  • Kidney(2.8)
  • Skin(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with LIMA1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LIMA1 Gene

Orthologs for LIMA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIMA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIMA1 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia LIMA1 34 35
  • 86.77 (n)
cow
(Bos Taurus)
Mammalia LIMA1 34 35
  • 86.08 (n)
mouse
(Mus musculus)
Mammalia Lima1 34 16 35
  • 80.43 (n)
rat
(Rattus norvegicus)
Mammalia Lima1 34
  • 80.22 (n)
oppossum
(Monodelphis domestica)
Mammalia LIMA1 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIMA1 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves LIMA1 34 35
  • 66.8 (n)
lizard
(Anolis carolinensis)
Reptilia LIMA1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lima1 34
  • 57.74 (n)
Str.6869 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24780 34
zebrafish
(Danio rerio)
Actinopterygii im:7155904 34
  • 51.45 (n)
lima1 35
  • 38 (a)
OneToMany
LIMA1 (2 of 2) 35
  • 20 (a)
OneToMany
-- 34
Species where no ortholog for LIMA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIMA1 Gene

ENSEMBL:
Gene Tree for LIMA1 (if available)
TreeFam:
Gene Tree for LIMA1 (if available)

Paralogs for LIMA1 Gene

Paralogs for LIMA1 Gene

(1) SIMAP similar genes for LIMA1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with LIMA1: view

Variants for LIMA1 Gene

Sequence variations from dbSNP and Humsavar for LIMA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000044839 -- 50,229,308(+) CCTGC(A/G)ATCCT intron-variant
rs1000065145 -- 50,239,274(+) GGAAG(A/G)GGAAA intron-variant
rs1000130837 -- 50,257,546(+) TGAAC(C/T)TGTGA intron-variant
rs1000182514 -- 50,211,197(+) GGACA(C/T)CTGTA intron-variant
rs1000188748 -- 50,203,340(+) AGTTC(C/T)GTAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LIMA1 Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
esv2745869 CNV deletion 23290073
esv2745870 CNV deletion 23290073
esv2761738 CNV gain 21179565
esv3303601 CNV mobile element insertion 20981092
esv3334002 CNV insertion 20981092
esv3629477 CNV loss 21293372
nsv702 CNV deletion 18451855
nsv975487 CNV duplication 23825009

Variation tolerance for LIMA1 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIMA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LIMA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LIMA1 Gene

Disorders for LIMA1 Gene

Relevant External Links for LIMA1

Genetic Association Database (GAD)
LIMA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LIMA1

No disorders were found for LIMA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LIMA1 Gene

Publications for LIMA1 Gene

  1. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. (PMID: 12566430) Maul R.S. … Chang D.D. (J. Cell Biol. 2003) 2 3 4 22 64
  2. Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms. (PMID: 10806352) Chen S. … Chang D.D. (Gene 2000) 2 3 4 22 64
  3. EPLIN, epithelial protein lost in neoplasm. (PMID: 10618726) Maul R.S. … Chang D.D. (Oncogene 1999) 2 3 4 22 64
  4. The actin-binding and bundling protein, EPLIN, is required for cytokinesis. (PMID: 19221476) Chircop M. … Khanna K.K. (Cell Cycle 2009) 3 22 64
  5. EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt. (PMID: 18093941) Abe K. … Takeichi M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64

Products for LIMA1 Gene

  • Addgene plasmids for LIMA1

Sources for LIMA1 Gene

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