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Aliases for LIM2 Gene

Aliases for LIM2 Gene

  • Lens Intrinsic Membrane Protein 2, 19kDa 2 3
  • MP19 3 4 6
  • CTRCT19 3 6
  • MP18 3 4
  • MP20 3 4
  • Lens Intrinsic Membrane Protein 2 (19kD) 2
  • Lens Fiber Membrane Intrinsic Protein 3
  • MP17 3

External Ids for LIM2 Gene

Previous GeneCards Identifiers for LIM2 Gene

  • GC19M052513
  • GC19M052244
  • GC19M056559
  • GC19M056574
  • GC19M051887
  • GC19M048215

Summaries for LIM2 Gene

Entrez Gene Summary for LIM2 Gene

  • This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for LIM2 Gene

LIM2 (Lens Intrinsic Membrane Protein 2, 19kDa) is a Protein Coding gene. Diseases associated with LIM2 include cataract 19 and cataract, cortical pulverulent, late-onset. GO annotations related to this gene include structural constituent of eye lens.

UniProtKB/Swiss-Prot for LIM2 Gene

  • Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis

Gene Wiki entry for LIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIM2 Gene

Genomics for LIM2 Gene

Regulatory Elements for LIM2 Gene

Genomic Location for LIM2 Gene

Start:
51,379,909 bp from pter
End:
51,387,960 bp from pter
Size:
8,052 bases
Orientation:
Minus strand

Genomic View for LIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIM2 Gene

Proteins for LIM2 Gene

  • Protein details for LIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55344-LMIP_HUMAN
    Recommended name:
    Lens fiber membrane intrinsic protein
    Protein Accession:
    P55344
    Secondary Accessions:
    • Q6B083
    • Q9BXD0
    • Q9HAR5

    Protein attributes for LIM2 Gene

    Size:
    173 amino acids
    Molecular mass:
    19674 Da
    Quaternary structure:
    • Seems to be associated with itself or another lens membrane component via disulfide bonds

    Alternative splice isoforms for LIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LIM2 Gene

Proteomics data for LIM2 Gene at MOPED

Post-translational modifications for LIM2 Gene

  • Glycosylation at Trp43, Trp61, and Asn62
  • Modification sites at PhosphoSitePlus

Other Protein References for LIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIM2 Gene

Domains for LIM2 Gene

Suggested Antigen Peptide Sequences for LIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55344

UniProtKB/Swiss-Prot:

LMIP_HUMAN :
  • P55344
Family:
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with LIM2: view

No data available for Gene Families for LIM2 Gene

Function for LIM2 Gene

Molecular function for LIM2 Gene

GENATLAS Biochemistry: major intrinsic protein of lens fiber,2 (MP19),with water channel properties
UniProtKB/Swiss-Prot Function: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis

Gene Ontology (GO) - Molecular Function for LIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
genes like me logo Genes that share ontologies with LIM2: view

Phenotypes for LIM2 Gene

genes like me logo Genes that share phenotypes with LIM2: view

Animal Model Products

CRISPR Products

miRNA for LIM2 Gene

miRTarBase miRNAs that target LIM2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LIM2 Gene

Localization for LIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LIM2 Gene COMPARTMENTS Subcellular localization image for LIM2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction NAS 2584203
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with LIM2: view

Pathways for LIM2 Gene

SuperPathways for LIM2 Gene

No Data Available

Interacting Proteins for LIM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000221973%0d%0a9606.ENSP00000254301%0d%0a
Selected Interacting proteins: ENSP00000221973 P55344-LMIP_HUMAN for LIM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002088 lens development in camera-type eye IEA --
GO:0007043 cell-cell junction assembly NAS 2584203
GO:0043010 camera-type eye development --
genes like me logo Genes that share ontologies with LIM2: view

No data available for Pathways by source for LIM2 Gene

Compounds for LIM2 Gene

(2) Novoseek inferred chemical compound relationships for LIM2 Gene

Compound -log(P) Hits PubMed IDs
mp 19 98.2 11
mp 26 89.5 2
genes like me logo Genes that share compounds with LIM2: view

Transcripts for LIM2 Gene

mRNA/cDNA for LIM2 Gene

Unigene Clusters for LIM2 Gene

Lens intrinsic membrane protein 2, 19kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LIM2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LIM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LIM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2:
SP3:

Relevant External Links for LIM2 Gene

GeneLoc Exon Structure for
LIM2
ECgene alternative splicing isoforms for
LIM2

Expression for LIM2 Gene

mRNA expression in normal human tissues for LIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIM2 Gene

This gene is overexpressed in Whole Blood (40.7).

SOURCE GeneReport for Unigene cluster for LIM2 Gene Hs.162754

mRNA Expression by UniProt/SwissProt for LIM2 Gene

P55344-LMIP_HUMAN
Tissue specificity: Eye lens specific.
genes like me logo Genes that share expressions with LIM2: view

In Situ Assay Products

No data available for Protein expression for LIM2 Gene

Orthologs for LIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LIM2 35
  • 99.53 (n)
  • 99.07 (a)
LIM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LIM2 35
  • 90.94 (n)
  • 91.33 (a)
LIM2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LIM2 35
  • 91.33 (n)
  • 91.91 (a)
LIM2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lim2 35
  • 88.63 (n)
  • 91.33 (a)
Lim2 16
Lim2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LIM2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LIM2 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lim2 35
  • 89.21 (n)
  • 91.91 (a)
lizard
(Anolis carolinensis)
Reptilia LIM2 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17586 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lim2 35
  • 74.57 (n)
  • 78.61 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1612 35
zebrafish
(Danio rerio)
Actinopterygii lim2.1 36
  • 65 (a)
OneToMany
lim2.3 36
  • 63 (a)
OneToMany
lim2.4 36
  • 67 (a)
OneToMany
lim2.5 35
  • 73.41 (n)
  • 78.61 (a)
lim2.5 36
  • 79 (a)
OneToMany
Species with no ortholog for LIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIM2 Gene

ENSEMBL:
Gene Tree for LIM2 (if available)
TreeFam:
Gene Tree for LIM2 (if available)

Paralogs for LIM2 Gene

No data available for Paralogs for LIM2 Gene

Variants for LIM2 Gene

Sequence variations from dbSNP and Humsavar for LIM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1978455 -- 51,383,327(+) actgc(A/G)cccag intron-variant
rs1978456 -- 51,383,461(+) ttgct(G/T)tctca intron-variant
rs2547308 -- 51,387,491(-) AGTCC(C/T)GGGAA intron-variant
rs2547309 -- 51,387,487(-) CCGGG(A/G)ATTCA intron-variant
rs2547310 -- 51,387,312(-) TGGCG(A/G)TACTG synonymous-codon, reference

Relevant External Links for LIM2 Gene

HapMap Linkage Disequilibrium report
LIM2
Human Gene Mutation Database (HGMD)
LIM2
Locus Specific Mutation Databases (LSDB)
LIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LIM2 Gene

Disorders for LIM2 Gene

(1) OMIM Diseases for LIM2 Gene (154045)

UniProtKB/Swiss-Prot

LMIP_HUMAN
  • Cataract 19 (CTRCT19) [MIM:615277]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:11917274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for LIM2 Gene

Disease -log(P) Hits PubMed IDs
cataract 48.9 2

Relevant External Links for LIM2

Human Genome Epidemiology (HuGE) Navigator
LIM2
genes like me logo Genes that share disorders with LIM2: view

Publications for LIM2 Gene

  1. Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19). (PMID: 8666393) Kerscher S. … Lyon M.F. (Genomics 1995) 3 23
  2. Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB. (PMID: 8197479) Lieuallen K. … Lennon G. (Somat. Cell Mol. Genet. 1994) 3 23
  3. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. (PMID: 11532191) Gonen T. … Kistler J. (BMC Cell Biol. 2001) 3 23
  4. Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene (LIM2). (PMID: 15968979) Hsu H. … Church R.L. (Sheng Wu Gong Cheng Xue Bao 2004) 3 23
  5. Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19. (PMID: 1606837) Church R.L. … Wang J. (Curr. Eye Res. 1992) 2 3

Products for LIM2 Gene

Sources for LIM2 Gene

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