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LIM2 Gene

protein-coding   GIFtS: 53
GCID: GC19M051887

Lens Intrinsic Membrane Protein 2, 19kDa

(Previous name: lens intrinsic membrane protein 2 (19kD))
  See LIM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lens Intrinsic Membrane Protein 2, 19kDa1 2     CTRCT192 5
MP192 3 5     Lens Intrinsic Membrane Protein 2 (19kD)1
MP182 3     MP172
MP202 3     Lens Fiber Membrane Intrinsic Protein2

External Ids:    HGNC: 66101   Entrez Gene: 39822   Ensembl: ENSG000001053707   OMIM: 1540455   UniProtKB: P553443   

Export aliases for LIM2 gene to outside databases

Previous GC identifers: GC19M052513 GC19M052244 GC19M056559 GC19M056574 GC19M048215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LIM2 Gene:
This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute
to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both
lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by
RefSeq, Sep 2009)

GeneCards Summary for LIM2 Gene:
LIM2 (lens intrinsic membrane protein 2, 19kDa) is a protein-coding gene. Diseases associated with LIM2 include cataract 19, and cataract, cortical pulverulent, late-onset. GO annotations related to this gene include structural constituent of eye lens.

UniProtKB/Swiss-Prot: LMIP_HUMAN, P55344
Function: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell
junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development
and cataractogenesis

Gene Wiki entry for LIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LIM2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   POU3F1   Pax-6   HSF1 (long)   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLIM2 promoter sequence
   Search Chromatin IP Primers for LIM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.4

LIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LIM2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051887:  view genomic region     (about GC identifiers)

Start:
51,883,163 bp from pter      End:
51,891,214 bp from pter
Size:
8,052 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LMIP_HUMAN, P55344 (See protein sequence)
Recommended Name: Lens fiber membrane intrinsic protein  
Size: 173 amino acids; 19674 Da
Subunit: Seems to be associated with itself or another lens membrane component via disulfide bonds
Secondary accessions: Q6B083 Q9BXD0 Q9HAR5
Alternative splicing: 2 isoforms:  P55344-1   P55344-2   

Explore the universe of human proteins at neXtProt for LIM2: NX_P55344

Explore proteomics data for LIM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Trp43, Trp61, Asn62
  • Modification sites at PhosphoSitePlus

  • See LIM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155220.1  NP_085915.2  

    ENSEMBL proteins: 
     ENSP00000221973   ENSP00000472090  

    LIM2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LIM2

     
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    antibodies-online proteins for LIM2 

     
    antibodies-online peptides for LIM2

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    antibodies-online antibodies for LIM2 (14 products) 

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    antibodies-online kits for LIM2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004032 PMP22_EMP_MP20
     IPR003935 LMIP
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry P55344

    ProtoNet protein and cluster: P55344

    2 Blocks protein domains:
    IPB003935 Lens fibre membrane intrinsic protein (LMIP) signature
    IPB004032 PMP-22/EMP/MP20 family


    UniProtKB/Swiss-Prot: LMIP_HUMAN, P55344
    Similarity: Belongs to the PMP-22/EMP/MP20 family


    Find genes that share domains with LIM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMIP_HUMAN, P55344
    Function: Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell
    junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development
    and cataractogenesis

         Genatlas biochemistry entry for LIM2:
    major intrinsic protein of lens fiber,2 (MP19),with water channel properties

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
         
    Find genes that share ontologies with LIM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LIM2:
     Decreased G3BP1 protein expres 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Lim2):
     vision/eye 

    Find genes that share phenotypes with LIM2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LIM2

    miRNA
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    miRTarBase miRNAs that target LIM2:
    hsa-mir-335-5p (MIRT018500)

    Block miRNA regulation of human, mouse, rat LIM2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LIM2:
    hsa-miR-877* hsa-miR-4328 hsa-miR-3943
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMIP_HUMAN, P55344: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction NAS2584203
    GO:0031982vesicle IEA--

    Find genes that share ontologies with LIM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LIM2
    Interactions:

        Search GeneGlobe Interaction Network for LIM2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for LIM2 (P553443 ENSP000002219734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS3P179313, ENSP000002543014I2D: score=1 STRING: ENSP00000254301
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002088lens development in camera-type eye IEA--
    GO:0007043cell-cell junction assembly NAS2584203
    GO:0043010camera-type eye development ----

    Find genes that share ontologies with LIM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LIM2 (LMIP)

    2 Novoseek inferred chemical compound relationships for LIM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mp 19 98.2 20 11290961 (5), 8666393 (2), 8197479 (1), 8812411 (1) (see all 6)
    mp 26 89.5 2 1491428 (1), 8300349 (1)



    Find genes that share compounds with LIM2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LIM2 gene (2 alternative transcripts): 
    NM_001161748.1  NM_030657.3  

    Unigene Cluster for LIM2:

    Lens intrinsic membrane protein 2, 19kDa
    Hs.162754  [show with all ESTs]
    Unigene Representative Sequence: NM_030657
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221973(uc002pwm.2 uc002pwl.2) ENST00000596399
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate LIM2:
    hsa-miR-877* hsa-miR-4328 hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidLIM2 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LIM2
      QuantiTect SYBR Green Assays in human, mouse, rat LIM2
      QuantiFast Probe-based Assays in human, mouse, rat LIM2

    Additional mRNA sequence: 

    AF340019.1 AF340020.1 BC069430.1 BC074916.2 BC074917.2 BC126139.1 

    2 DOTS entries:

    DT.100748099  DT.97841334 

    Selected AceView cDNA sequences (see all 115):

    BU735198 BM707642 BM669926 BF726484 BF726953 BF726389 BQ053800 CB216430 
    CD675859 BM564372 BF726526 BF727436 BF726502 AF340020 BC074916 BM699967 
    NM_005601 BM917505 BQ051624 BM696344 BM669089 NM_030657 BM693674 BC069430 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LIM2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
    SP1:              -                           
    SP2:                                          
    SP3:                                          


    ECgene alternative splicing isoforms for LIM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGAGCT
    LIM2 Expression
    About this image


    LIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Eye (Sensory Organs)
    LIM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LIM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162754

    UniProtKB/Swiss-Prot: LMIP_HUMAN, P55344
    Tissue specificity: Eye lens specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LIM2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lim21 , 5 lens intrinsic membrane protein 21, 5 88.63(n)1
    91.33(a)1
      7 (28.25 cM)5
    2331871  NM_177693.31  NP_808361.11 
     434301015 
    lizard
    (Anolis carolinensis)
    Reptilia LIM26
    lens intrinsic membrane protein 2, 19kDa
    64(a)
    1 ↔ 1
    GL343281.1(884957-903915)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.175862 Xenopus laevis transcribed sequence with moderate similarity more 81.92(n)    BX850976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lim2.51 lens intrinsic membrane protein 2.5 73.41(n)
    78.61(a)
      541395  NM_001013522.1  NP_001013540.1 


    ENSEMBL Gene Tree for LIM2 (if available)
    TreeFam Gene Tree for LIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LIM2 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697964
    Cataract 19 (CTRCT19)4--see VAR_0697962 F V mis40--------
    rs1120642191,2
    C,F--51885137(+) ACCACA/GCCTGG 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs25473211,2
    C,F,O,H--52064713(-) TCAACG/TTCCAG 2 -- ds500131Minor allele frequency- N:0.00EA NA NS WA CSA 4614
    rs1380104971,2
    C--52064763(+) CTGTTC/TCCCTC 2 -- ds50010--------
    rs1894675511,2
    --52064921(+) GTGAAA/GCCCCA 2 -- ds50010--------
    rs1818211571,2
    --52065000(+) GCTGAA/GGCAGG 2 -- ds50010--------
    rs1439340391,2
    --52065013(+) AATCAC/TTTGAA 2 -- ds50010--------
    rs1139310001,2
    C--52065038(+) GTTGCG/AGTGAG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1473215471,2
    C--52065051(+) GAGATC/TGCACC 2 -- ds50010--------
    rs1430203381,2
    --52065078(+) GGCAAA/CAAAGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LIM2 (51883163 - 51891214 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LIM2: --
    Human Gene Mutation Database (HGMD): LIM2
    Locus Specific Mutation Databases (LSDB): LIM2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for LIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 154045   
    OMIM disorders: 615277  
    UniProtKB/Swiss-Prot: LMIP_HUMAN, P55344
  • Cataract 19 (CTRCT19) [MIM:615277]: An opacification of the crystalline lens of the eye that frequently
    results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the
    lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the
    greater the impact on visual function. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 4 diseases for LIM2:    
    About MalaCards
    cataract 19    cataract, cortical pulverulent, late-onset    cataract 1, multiple types    cataract


    Find genes that share disorders with LIM2           About GenesLikeMe

    1 Novoseek inferred disease relationship for LIM2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 48.9 2 18596884 (2)

    Human Genome Epidemiology (HuGE) Navigator: LIM2 (1 document)

    Export disorders for LIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LIM2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with LIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1, 2 Wistow G.... Peterson K. (Mol. Vis. 2002)
    2. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. (PubMed id 11917274)1, 2 Pras E....Pras E. (Am. J. Hum. Genet. 2002)
    3. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. (PubMed id 8137630)1, 2 Church R.L. and Wang J.H. (Curr. Eye Res. 1993)
    4. Assignment of the lens intrinsic membrane protein MP19 structural gene to human chromosome 19. (PubMed id 1606837)1, 3 Church R.L. and Wang J. (Curr. Eye Res. 1992)
    5. Identification of an 18,000-dalton protein in mammalian lens fiber cell membranes. (PubMed id 2584203)1, 2 Louis C.F.... Howard J.B. (J. Biol. Chem. 1989)
    6. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. (PubMed id 11532191)1, 9 Gonen T....Kistler J. (BMC Cell Biol. 2001)
    7. A missense mutation in LIM2 causes autosomal recessive congenital cataract. (PubMed id 18596884)1, 9 Ponnam S.P....Kannabiran C. (Mol. Vis. 2008)
    8. Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19). (PubMed id 8666393)1, 9 Kerscher S....Lyon M.F. (Genomics 1995)
    9. Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB. (PubMed id 8197479)1, 9 Lieuallen K....Lennon G. (Somat. Cell Mol. Genet. 1994)
    10. Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene (LIM2). (PubMed id 15968979)1, 9 Hsu H....Church R.L. (Sheng Wu Gong Cheng Xue Bao 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3982 HGNC: 6610 AceView: NKG7andLIM2 Ensembl:ENSG00000105370 euGenes: HUgn3982
    ECgene: LIM2 H-InvDB: LIM2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LIM2 gene:
    Search GeneIP for patents involving LIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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