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Aliases for LIM2 Gene

Aliases for LIM2 Gene

  • Lens Intrinsic Membrane Protein 2 2 3 5
  • Lens Intrinsic Membrane Protein 2, 19kDa 2 3
  • MP18 3 4
  • MP19 3 4
  • MP20 3 4
  • Lens Intrinsic Membrane Protein 2 (19kD) 2
  • CTRCT19 3
  • MP17 3

External Ids for LIM2 Gene

Previous GeneCards Identifiers for LIM2 Gene

  • GC19M052513
  • GC19M052244
  • GC19M056559
  • GC19M056574
  • GC19M051887
  • GC19M048215

Summaries for LIM2 Gene

Entrez Gene Summary for LIM2 Gene

  • This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for LIM2 Gene

LIM2 (Lens Intrinsic Membrane Protein 2) is a Protein Coding gene. Diseases associated with LIM2 include cataract 19 and total early-onset cataract. GO annotations related to this gene include structural constituent of eye lens.

UniProtKB/Swiss-Prot for LIM2 Gene

  • Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

Gene Wiki entry for LIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LIM2 Gene

Genomics for LIM2 Gene

Regulatory Elements for LIM2 Gene

Genomic Location for LIM2 Gene

51,379,909 bp from pter
51,387,960 bp from pter
8,052 bases
Minus strand

Genomic View for LIM2 Gene

Genes around LIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LIM2 Gene

Proteins for LIM2 Gene

  • Protein details for LIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lens fiber membrane intrinsic protein
    Protein Accession:
    Secondary Accessions:
    • Q6B083
    • Q9BXD0
    • Q9HAR5

    Protein attributes for LIM2 Gene

    173 amino acids
    Molecular mass:
    19674 Da
    Quaternary structure:
    • Seems to be associated with itself or another lens membrane component via disulfide bonds.

    Alternative splice isoforms for LIM2 Gene


neXtProt entry for LIM2 Gene

Proteomics data for LIM2 Gene at MOPED

Post-translational modifications for LIM2 Gene

  • Glycosylation at Trp 43, Trp 61, and Asn 62
  • Modification sites at PhosphoSitePlus

Other Protein References for LIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LIM2 Gene

Domains & Families for LIM2 Gene

Suggested Antigen Peptide Sequences for LIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family.
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with LIM2: view

No data available for Gene Families for LIM2 Gene

Function for LIM2 Gene

Molecular function for LIM2 Gene

GENATLAS Biochemistry:
major intrinsic protein of lens fiber,2 (MP19),with water channel properties
UniProtKB/Swiss-Prot Function:
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
genes like me logo Genes that share phenotypes with LIM2: view

Human Phenotype Ontology for LIM2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for LIM2 Gene

miRTarBase miRNAs that target LIM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for LIM2 Gene

Localization for LIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LIM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LIM2 Gene COMPARTMENTS Subcellular localization image for LIM2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction NAS 2584203
genes like me logo Genes that share ontologies with LIM2: view

Pathways & Interactions for LIM2 Gene

SuperPathways for LIM2 Gene

No Data Available

Interacting Proteins for LIM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000221973 P55344-LMIP_HUMAN for LIM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LIM2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LIM2 Gene

Drugs & Compounds for LIM2 Gene

(2) Additional Compounds for LIM2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LIM2: view

Transcripts for LIM2 Gene

mRNA/cDNA for LIM2 Gene

Unigene Clusters for LIM2 Gene

Lens intrinsic membrane protein 2, 19kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LIM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP1: -

Relevant External Links for LIM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LIM2 Gene

mRNA expression in normal human tissues for LIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LIM2 Gene

This gene is overexpressed in Whole Blood (x40.7).

SOURCE GeneReport for Unigene cluster for LIM2 Gene Hs.162754

mRNA Expression by UniProt/SwissProt for LIM2 Gene

Tissue specificity: Eye lens specific.
genes like me logo Genes that share expression patterns with LIM2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LIM2 Gene

Orthologs for LIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LIM2 35
  • 90.94 (n)
  • 91.33 (a)
LIM2 36
  • 91 (a)
(Canis familiaris)
Mammalia LIM2 35
  • 91.33 (n)
  • 91.91 (a)
LIM2 36
  • 92 (a)
(Mus musculus)
Mammalia Lim2 35
  • 88.63 (n)
  • 91.33 (a)
Lim2 16
Lim2 36
  • 91 (a)
(Pan troglodytes)
Mammalia LIM2 35
  • 99.53 (n)
  • 99.07 (a)
LIM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lim2 35
  • 89.21 (n)
  • 91.91 (a)
(Monodelphis domestica)
Mammalia LIM2 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia LIM2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia LIM2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lim2 35
  • 74.57 (n)
  • 78.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17586 35
(Danio rerio)
Actinopterygii lim2.5 35
  • 73.41 (n)
  • 78.61 (a)
lim2.1 36
  • 65 (a)
lim2.3 36
  • 63 (a)
lim2.4 36
  • 67 (a)
lim2.5 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1612 35
Species with no ortholog for LIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LIM2 Gene

Gene Tree for LIM2 (if available)
Gene Tree for LIM2 (if available)

Paralogs for LIM2 Gene

No data available for Paralogs for LIM2 Gene

Variants for LIM2 Gene

Sequence variations from dbSNP and Humsavar for LIM2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_069796 Cataract 19 (CTRCT19)
rs1978455 -- 51,383,327(+) actgc(A/G)cccag intron-variant
rs1978456 -- 51,383,461(+) ttgct(G/T)tctca intron-variant
rs2741232 -- 51,387,218(-) GGGGG(C/G)ACCTC intron-variant, reference, missense
rs2741233 -- 51,386,933(-) TGGAT(A/G)CTGAA intron-variant

Variation tolerance for LIM2 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LIM2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LIM2 Gene

Disorders for LIM2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for LIM2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cataract 19
  • cataract, cortical pulverulent, late-onset
total early-onset cataract
reducing body myopathy
  • reducing-body myopathy
scapuloperoneal myopathy
- elite association - COSMIC cancer census association via MalaCards
Search LIM2 in MalaCards View complete list of genes associated with diseases


  • Cataract 19 (CTRCT19) [MIM:615277]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:11917274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LIM2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LIM2: view

No data available for Genatlas for LIM2 Gene

Publications for LIM2 Gene

  1. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3 4 67
  2. A missense mutation in LIM2 causes autosomal recessive congenital cataract. (PMID: 18596884) Ponnam S.P. … Kannabiran C. (Mol. Vis. 2008) 3 23
  3. Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene (LIM2). (PMID: 15968979) Hsu H. … Church R.L. (Sheng Wu Gong Cheng Xue Bao 2004) 3 23
  4. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. (PMID: 11532191) Gonen T. … Kistler J. (BMC Cell Biol. 2001) 3 23
  5. Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19). (PMID: 8666393) Kerscher S. … Lyon M.F. (Genomics 1995) 3 23

Products for LIM2 Gene

Sources for LIM2 Gene

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