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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LILRB5 Gene

protein-coding   GIFtS: 54
GCID: GC19M054754

leukocyte immunoglobulin-like receptor, subfamily B (with...

 Explore 2 diseases affiliated with
LILRB5 via our new
 Human Malady Compendium 
Biological research products
for LILRB5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 51 2
     CD85c1
LIR81 2 3 5     CD85C2
LIR-81 2 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 52
Leukocyte Immunoglobulin-Like Receptor 82 3     CD85c Antigen3
CD85 Antigen-Like Family Member C2 3     

External Ids:    HGNC: 66091   Entrez Gene: 109902   Ensembl: ENSG000001056097   OMIM: 6048145   UniProtKB: O750233   

Export aliases for LILRB5 gene to outside databases

Previous GC identifers: GC19M055617 GC19M055178 GC19M059430 GC19M059446 GC19M051081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LILRB5:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or
four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor
tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where
they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LIRB5_HUMAN, O75023
Function: May act as receptor for class I MHC antigens

Gene Wiki entry for LILRB5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LILRB5 gene promoter:
         ER-alpha   AML1a   GCNF   E47   POU2F1   GCNF-1   POU2F1a   GCNF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LILRB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054754:  view genomic region     (about GC identifiers)

Start:
54,754,263 bp from pter      End:
54,761,167 bp from pter
Size:
6,905 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LIRB5_HUMAN, O75023 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor  
Size: 590 amino acids; 64126 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q8N760
Alternative splicing: 3 isoforms:  O75023-1   O75023-2   O75023-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB5: NX_O75023

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75023

  • LILRB5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001074911.1  NP_001074912.1  NP_006831.1  

    ENSEMBL proteins: 
     ENSP00000320390   ENSP00000263430   ENSP00000406478   ENSP00000414225  
    Reactome Protein details: O75023
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    Uscn Proteins for LILRB5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    LILRB5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LILRB5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75023

    ProtoNet protein and cluster: O75023

    UniProtKB/Swiss-Prot: LIRB5_HUMAN, O75023
    Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor
    motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the
    SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: LIRB5_HUMAN, O75023
    Function: May act as receptor for class I MHC antigens

         Genatlas biochemistry entry for LILRB5:
    leukocyte immunoglobulin-like receptor,subfamily B,member 5,expressed restrictively on natural killer cells,related to
    the Fc alpha receptor and natural killed inhibitory receptor superfamily

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS9548455


    LILRB5 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    Immune System1.00
    Adaptive Immune System0.59
    2Osteoclast differentiation
    Osteoclast differentiation1.00
    3Cleavage of Alpha-1-Microglobulin
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for LILRB5
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for LILRB5):
        Osteoclast differentiation


    LILRB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LILRB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for LILRB5 (O750233 ENSP000004064784) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    FCGR2AENSP000002714504STRING: ENSP00000271450
    FCGR3AENSP000003569464STRING: ENSP00000356946
    FCGR3BENSP000002948004STRING: ENSP00000294800
    SYKENSP000003648984STRING: ENSP00000364898
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response TAS9548455
    GO:0007166cell surface receptor signaling pathway TAS9548455


    LILRB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LILRB5
    Search CenterWatch for drugs/clinical trials and news about LILRB5 / LIRB5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LILRB5 gene (3 alternative transcripts): 
    NM_001081442.1  NM_001081443.1  NM_006840.3  

    Unigene Cluster for LILRB5:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
    Hs.655338  [show with all ESTs]
    Unigene Representative Sequence: AK301112
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316219 ENST00000466581 ENST00000345866 ENST00000463460(uc002qfa.1)
    ENST00000449561(uc002qex.3 uc002qey.3 uc002qez.3 uc010yes.1)
    ENST00000450632(uc010yer.1)

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    Additional cDNA sequence: 

    AF025534.1 AK057072.1 AK223296.1 AK290845.1 AK301112.1 AK301338.1 BC025704.1 

    14 DOTS entries:

    DT.110500  DT.121487157  DT.95263458  DT.97780856  DT.121487043  DT.100033680  DT.100033681  DT.121487133 
    DT.100648231  DT.100814430  DT.75189743  DT.92466967  DT.95375084  DT.97774796 

    8 AceView cDNA sequences:

    R10963 NM_006840 BX279927 AA372232 BQ942437 BC025704 AF025534 AA229099 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB5 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                      -     -     -                                                                                 
    SP5:                    -                                                                                                               


    ECgene alternative splicing isoforms for LILRB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LILRB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTATAAATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See LILRB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LILRB5

    SOURCE GeneReport for Unigene cluster: Hs.655338

    UniProtKB/Swiss-Prot: LIRB5_HUMAN, O75023
    Tissue specificity: Detected in a natural killer (NK) cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB5 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 59)
    --
    29(a)
    23(a)
    (see all 59)
    many ↔ many
    many ↔ many
    (see all 59)
    Un(51843257-51844123)
    Un(59460063-59462402)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    24(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343329.1(823590-844642)
    GL343329.1(1231914-1234163)


    ENSEMBL Gene Tree for LILRB5 (if available)
    TreeFam Gene Tree for LILRB5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LILRB5 gene
    KIR2DL42  LILRB42  LILRB12  LILRA62  IGSF12  LILRA52  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  KIR3DL32  LILRA12  
    KIR2DL12  LILRB22  A1BG2  KIR2DL22  LILRA22  KIR3DL22  KIR2DL32  FCAR2  
    LILRB32  GP62  
    18/46 SIMAP similar genes for LILRB5 using alignment to 2 protein entries:     LIRB5_HUMAN (see all proteins) (see all similar genes):
    LILRB2    LILRA6    MIR cl-10    LILRB3    LILRA2    LILRA1
    LILRA5    LILRA3    LILRB1    LILRA4    FLJ00275    KIR-K36
    KIR2DS    KIR412    KIR-K9    KIR-K15    KIR-K3    KIR-K64

    LILRB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 NCBI SNPs in LILRB5 are shown (see all 353    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379300941,2
    --54753784(+) TACTCA/GGGAGA 3 -- ds50010--------
    rs1492000931,2
    --54753823(+) GAGGCA/GGAGGT 3 -- ds50010--------
    rs1433296651,2
    --54753827(+) CAGAGC/GTTGCA 3 -- ds50010--------
    rs361717291,2
    C,--54753866(+) AGCCTG/-GGTGA 3 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1427651831,2
    C,--54753893(+) CTCAA-/AAAAC 
            
    AAAAC
    3 -- ds50010--------
    rs559251881,2
    C--54753897(+) CAAAA-/CAAAA 
            
    ACCCT
    3 -- ds50011Minor allele frequency- CAAAA:0.00NA 2
    rs1483823251,2
    --54753961(+) CACAAC/GTTTAT 3 -- ds50010--------
    rs1895860031,2
    --54754048(+) TGGTGC/TCTGCT 3 -- ds50010--------
    rs116681891,2
    C,F,A,H,--54754103(+) CCTTGC/ATTATT 3 -- ds50018Minor allele frequency- A:0.24NA WA 250
    rs1415565111,2
    --54754320(+) ATTCAC/TTCGCT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for LILRB5 (54754263 - 54761167 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for LILRB5
         9 CNVs: 35676 4088 35680 35677 0520 9815 3199 23217 53540

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LILRB5 for disorders           About GeneDecksing

    OMIM gene information: 604814    OMIM disorders: --

    2 diseases for LILRB5:    About MalaCards
    hepatitis b    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: LILRB5 (3 documents)

    Export disorders for LILRB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LILRB5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with LILRB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2, 3 Borges L....Cosman D. (1997)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    6. Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells. (PubMed id 17998301)1 Tedla N....Arm J.P. (2008)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10990 HGNC: 6609 AceView: LILRB5 Ensembl:ENSG00000105609 euGenes: HUgn10990
    ECgene: LILRB5 Kegg: 10990 H-InvDB: LILRB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LILRB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LILRB5 gene:
    Search GeneIP for patents involving LILRB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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