Aliases for LILRB5 Gene
External Ids for LILRB5 Gene
Previous GeneCards Identifiers for LILRB5 Gene
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for LILRB5 Gene
LILRB5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is KIR2DL4.
UniProtKB/Swiss-Prot for LILRB5 Gene
May act as receptor for class I MHC antigens