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Aliases for LILRB4 Gene

Aliases for LILRB4 Gene

  • Leukocyte Immunoglobulin Like Receptor B4 2 3
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 4 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor 5 3 4
  • Monocyte Inhibitory Receptor HM18 3 4
  • CD85 Antigen-Like Family Member K 3 4
  • Immunoglobulin-Like Transcript 3 3 4
  • Leucocyte Ig-Like Receptor B4 2 3
  • ILT-3 3 4
  • LIR-5 3 4
  • ILT3 3 4
  • LIR5 3 4
  • CD85k Antigen 4
  • CD85K 3

External Ids for LILRB4 Gene

Previous GeneCards Identifiers for LILRB4 Gene

  • GC19U990164
  • GC19P055599
  • GC19P059762
  • GC19P059866
  • GC19P055155
  • GC19P051497

Summaries for LILRB4 Gene

Entrez Gene Summary for LILRB4 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB4 Gene

LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. Among its related pathways are Immune System and Osteoclast differentiation. GO annotations related to this gene include receptor activity and antigen binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRB4 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Wiki entry for LILRB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB4 Gene

Genomics for LILRB4 Gene

Regulatory Elements for LILRB4 Gene

Enhancers for LILRB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LILRB4 on UCSC Golden Path with GeneCards custom track

Promoters for LILRB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LILRB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRB4 Gene

Chromosome:
19
Start:
54,643,835 bp from pter
End:
54,670,359 bp from pter
Size:
26,525 bases
Orientation:
Plus strand

Genomic View for LILRB4 Gene

Genes around LILRB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB4 Gene

Proteins for LILRB4 Gene

  • Protein details for LILRB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHJ6-LIRB4_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 4
    Protein Accession:
    Q8NHJ6
    Secondary Accessions:
    • A8MVL8
    • O15468
    • O75021
    • Q6FGQ9
    • Q8N1C7
    • Q8NHL5

    Protein attributes for LILRB4 Gene

    Size:
    448 amino acids
    Molecular mass:
    49356 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated.

    Three dimensional structures from OCA and Proteopedia for LILRB4 Gene

    Alternative splice isoforms for LILRB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB4 Gene

Proteomics data for LILRB4 Gene at MOPED

Post-translational modifications for LILRB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for LILRB4 (LILRB4/CD85k/ILT3)

No data available for DME Specific Peptides for LILRB4 Gene

Domains & Families for LILRB4 Gene

Protein Domains for LILRB4 Gene

Suggested Antigen Peptide Sequences for LILRB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHJ6

UniProtKB/Swiss-Prot:

LIRB4_HUMAN :
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRB4: view

Function for LILRB4 Gene

Molecular function for LILRB4 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 4,mouse Gp49B-1 ortholog,expressed on monocytes,B cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,with several alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
UniProtKB/Swiss-Prot Induction:
Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.

Gene Ontology (GO) - Molecular Function for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9151699
GO:0005515 protein binding IEA,IPI 18802077
genes like me logo Genes that share ontologies with LILRB4: view
genes like me logo Genes that share phenotypes with LILRB4: view

Animal Models for LILRB4 Gene

MGI Knock Outs for LILRB4:

Animal Model Products

  • Taconic Biosciences Mouse Models for LILRB4

CRISPR Products

miRNA for LILRB4 Gene

miRTarBase miRNAs that target LILRB4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LILRB4 Gene

Localization for LILRB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LILRB4 Gene COMPARTMENTS Subcellular localization image for LILRB4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for LILRB4 Gene

Pathways & Interactions for LILRB4 Gene

genes like me logo Genes that share pathways with LILRB4: view

Pathways by source for LILRB4 Gene

Interacting Proteins for LILRB4 Gene

Gene Ontology (GO) - Biological Process for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9151699
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter IDA 22387553
genes like me logo Genes that share ontologies with LILRB4: view

No data available for SIGNOR curated interactions for LILRB4 Gene

Drugs & Compounds for LILRB4 Gene

(3) Drugs for LILRB4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LILRB4: view

Transcripts for LILRB4 Gene

mRNA/cDNA for LILRB4 Gene

(32) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRB4 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for LILRB4 Gene

GeneLoc Exon Structure for
LILRB4
ECgene alternative splicing isoforms for
LILRB4

Expression for LILRB4 Gene

mRNA expression in normal human tissues for LILRB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRB4 Gene

This gene is overexpressed in Whole Blood (x13.4).

Protein differential expression in normal tissues from HIPED for LILRB4 Gene

This gene is overexpressed in Heart (52.3), Urine (8.9), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRB4 Gene



SOURCE GeneReport for Unigene cluster for LILRB4 Gene Hs.67846

mRNA Expression by UniProt/SwissProt for LILRB4 Gene

Q8NHJ6-LIRB4_HUMAN
Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
genes like me logo Genes that share expression patterns with LILRB4: view

Protein tissue co-expression partners for LILRB4 Gene

Primer Products

Orthologs for LILRB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Lilrb4 35
  • 63.14 (n)
  • 50 (a)
Lilrb4a 16
Lilra5 36
  • 39 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LILRB4 35
  • 97.13 (n)
  • 94.94 (a)
LILRB4 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lilrb4 35
  • 58.9 (n)
  • 48.19 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
OneToMany
Species with no ortholog for LILRB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB4 Gene

ENSEMBL:
Gene Tree for LILRB4 (if available)
TreeFam:
Gene Tree for LILRB4 (if available)

Paralogs for LILRB4 Gene

Pseudogenes.org Pseudogenes for LILRB4 Gene

genes like me logo Genes that share paralogs with LILRB4: view

Variants for LILRB4 Gene

Sequence variations from dbSNP and Humsavar for LILRB4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_017014 -
VAR_017015 -
VAR_025501 -
VAR_025502 -
VAR_025503 -

Structural Variations from Database of Genomic Variants (DGV) for LILRB4 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv470158 CNV Loss 18288195
dgv16e196 CNV Duplication 17116639
dgv17e196 CNV Deletion 17116639
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv458799 CNV Gain 19166990
dgv4006n71 CNV Loss 21882294
esv2718879 CNV Deletion 23290073
nsv9760 CNV Loss 18304495
nsv828639 CNV Loss 20364138
nsv470159 CNV Gain 18288195
nsv523723 CNV Loss 19592680
nsv817871 CNV Loss 17921354
nsv912419 CNV Loss 21882294
essv4924 CNV CNV 17122850
esv2422341 CNV Duplication 17116639
nsv518953 CNV Loss 19592680
nsv833879 CNV Gain+Loss 17160897
nsv524470 CNV Gain 19592680

Variation tolerance for LILRB4 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.07; 90.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LILRB4 Gene

Disorders for LILRB4 Gene

Relevant External Links for LILRB4

Genetic Association Database (GAD)
LILRB4
Human Genome Epidemiology (HuGE) Navigator
LILRB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRB4

No disorders were found for LILRB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRB4 Gene

Publications for LILRB4 Gene

  1. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PMID: 9151699) Cella M. … Colonna M. (J. Exp. Med. 1997) 2 3 4 23 67
  2. Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases. (PMID: 19833736) Lu H.K. … Tedla N. (J. Biol. Chem. 2009) 3 23
  3. Polymorphism and linkage disequilibrium of immunoglobulin-like transcript 3 gene. (PMID: 18486764) Chang C.C. … Vasilescu E.R. (Hum. Immunol. 2008) 3 23
  4. Changes in the expression of the immunoglobulin-like transcript 3 (ILT3) and ILT4 receptors in renal allograft recipients: effect of donor and recipient aging. (PMID: 19010139) Benito M.J. … Arias M. (Transplant. Proc. 2008) 3 23
  5. Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia. (PMID: 17266150) Colovai A.I. … Suciu-Foca N. (Cytometry B Clin Cytom 2007) 3 23

Products for LILRB4 Gene

Sources for LILRB4 Gene

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