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Aliases for LILRB4 Gene

Aliases for LILRB4 Gene

  • Leukocyte Immunoglobulin Like Receptor B4 2 3 5
  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 4 2 3
  • Leukocyte Immunoglobulin-Like Receptor 5 3 4
  • Monocyte Inhibitory Receptor HM18 3 4
  • CD85 Antigen-Like Family Member K 3 4
  • Immunoglobulin-Like Transcript 3 3 4
  • Leucocyte Ig-Like Receptor B4 2 3
  • ILT-3 3 4
  • LIR-5 3 4
  • ILT3 3 4
  • LIR5 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 3
  • CD85k Antigen 4
  • CD85K 3

External Ids for LILRB4 Gene

Previous GeneCards Identifiers for LILRB4 Gene

  • GC19U990164
  • GC19P055599
  • GC19P059762
  • GC19P059866
  • GC19P055155
  • GC19P051497

Summaries for LILRB4 Gene

Entrez Gene Summary for LILRB4 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB4 Gene

LILRB4 (Leukocyte Immunoglobulin Like Receptor B4) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune System. GO annotations related to this gene include receptor activity and antigen binding. An important paralog of this gene is LILRB3.

UniProtKB/Swiss-Prot for LILRB4 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Wiki entry for LILRB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB4 Gene

Genomics for LILRB4 Gene

Regulatory Elements for LILRB4 Gene

Enhancers for LILRB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F054661 1.3 FANTOM5 ENCODE 14.5 +18.1 18132 2.4 HDAC1 TBP ARNT WRNIP1 ZNF76 SIN3A GLI4 ZBTB40 ZNF335 GLIS2 FCAR LILRB4 LAIR1 KIR3DX1 LILRB2 KIR2DL3 LILRB1 LILRA5 LILRB3 LILRA1
GH19F054642 1.4 FANTOM5 Ensembl ENCODE 7.4 +0.2 166 2.8 HDAC1 PKNOX1 ZNF335 ZNF316 ZFHX2 POLR2A KLF8 EGR2 SP3 L3MBTL2 LILRA1 LAIR1 FCAR LILRB1 LILRB3 LILRB4 LILRA2 LILRB2 LILRA5 LAIR2
GH19F054459 1.7 FANTOM5 Ensembl ENCODE 4.9 -178.0 -177981 12.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 PAF1 SP3 SP5 KAT8 ENSG00000267838 LENG9 LENG8-AS1 TTYH1 CDC42EP5 ENSG00000237017 LILRB4 NLRP2
GH19F054270 1.2 FANTOM5 Ensembl ENCODE 6.3 -371.9 -371935 2.2 ZNF316 PKNOX1 NFE2 CUX1 LAIR1 LILRB2 OSCAR MYADM LILRB3 LILRB1 LILRA5 VSTM1 LILRB4 NLRP12
GH19F054373 1.2 FANTOM5 ENCODE 6.2 -268.9 -268918 2.7 PKNOX1 TBL1XR1 EBF1 RELA YY1 ZNF316 EED ZNF143 ETV6 NFE2 FCAR LAIR1 LILRB2 OSCAR LILRA5 VSTM1 LILRB3 LILRB4 LILRB1 LILRA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LILRB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LILRB4 Gene

Chromosome:
19
Start:
54,643,835 bp from pter
End:
54,670,359 bp from pter
Size:
26,525 bases
Orientation:
Plus strand

Genomic View for LILRB4 Gene

Genes around LILRB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LILRB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LILRB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB4 Gene

Proteins for LILRB4 Gene

  • Protein details for LILRB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHJ6-LIRB4_HUMAN
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 4
    Protein Accession:
    Q8NHJ6
    Secondary Accessions:
    • A8MVL8
    • O15468
    • O75021
    • Q6FGQ9
    • Q8N1C7
    • Q8NHL5

    Protein attributes for LILRB4 Gene

    Size:
    448 amino acids
    Molecular mass:
    49356 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated.

    Three dimensional structures from OCA and Proteopedia for LILRB4 Gene

    Alternative splice isoforms for LILRB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LILRB4 Gene

Post-translational modifications for LILRB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for LILRB4 (LILRB4/CD85k/ILT3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for LILRB4

No data available for DME Specific Peptides for LILRB4 Gene

Domains & Families for LILRB4 Gene

Protein Domains for LILRB4 Gene

Suggested Antigen Peptide Sequences for LILRB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHJ6

UniProtKB/Swiss-Prot:

LIRB4_HUMAN :
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Domain:
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRB4: view

Function for LILRB4 Gene

Molecular function for LILRB4 Gene

GENATLAS Biochemistry:
leukocyte immunoglobulin-like receptor,subfamily B,member 4,mouse Gp49B-1 ortholog,expressed on monocytes,B cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,with several alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
UniProtKB/Swiss-Prot Induction:
Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells.

Gene Ontology (GO) - Molecular Function for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9151699
GO:0004872 receptor activity TAS 9151699
GO:0005515 protein binding IPI 18802077
genes like me logo Genes that share ontologies with LILRB4: view
genes like me logo Genes that share phenotypes with LILRB4: view

Animal Models for LILRB4 Gene

MGI Knock Outs for LILRB4:

Animal Model Products

  • Taconic Biosciences Mouse Models for LILRB4

miRNA for LILRB4 Gene

miRTarBase miRNAs that target LILRB4

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRB4 (LILRB4/CD85k/ILT3)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LILRB4 Gene

Localization for LILRB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LILRB4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,NAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LILRB4: view

Pathways & Interactions for LILRB4 Gene

genes like me logo Genes that share pathways with LILRB4: view

Pathways by source for LILRB4 Gene

Gene Ontology (GO) - Biological Process for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 9151699
GO:0045671 negative regulation of osteoclast differentiation IDA 18802077
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter IDA 22387553
genes like me logo Genes that share ontologies with LILRB4: view

No data available for SIGNOR curated interactions for LILRB4 Gene

Drugs & Compounds for LILRB4 Gene

(3) Drugs for LILRB4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with LILRB4: view

Transcripts for LILRB4 Gene

mRNA/cDNA for LILRB4 Gene

(10) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LILRB4 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for LILRB4 (LILRB4/CD85k/ILT3)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2:
SP3:
SP4: - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for LILRB4 Gene

GeneLoc Exon Structure for
LILRB4
ECgene alternative splicing isoforms for
LILRB4

Expression for LILRB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LILRB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LILRB4 Gene

This gene is overexpressed in Whole Blood (x13.4).

Protein differential expression in normal tissues from HIPED for LILRB4 Gene

This gene is overexpressed in Heart (52.3), Urine (8.9), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LILRB4 Gene



Protein tissue co-expression partners for LILRB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LILRB4 Gene:

LILRB4

SOURCE GeneReport for Unigene cluster for LILRB4 Gene:

Hs.67846

mRNA Expression by UniProt/SwissProt for LILRB4 Gene:

Q8NHJ6-LIRB4_HUMAN
Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
genes like me logo Genes that share expression patterns with LILRB4: view

Orthologs for LILRB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LILRB4 34 35
  • 97.13 (n)
mouse
(Mus musculus)
Mammalia Lilrb4 34
  • 63.14 (n)
Lilra5 35
  • 39 (a)
ManyToMany
Lilrb4a 16
rat
(Rattus norvegicus)
Mammalia Lilrb4 34
  • 58.9 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 26 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 12 (a)
OneToMany
Species where no ortholog for LILRB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB4 Gene

ENSEMBL:
Gene Tree for LILRB4 (if available)
TreeFam:
Gene Tree for LILRB4 (if available)

Paralogs for LILRB4 Gene

genes like me logo Genes that share paralogs with LILRB4: view

Variants for LILRB4 Gene

Sequence variations from dbSNP and Humsavar for LILRB4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1048801 --
rs11540762 --
rs11574570 --
rs11574575 --
rs11574576 --

Structural Variations from Database of Genomic Variants (DGV) for LILRB4 Gene

Variant ID Type Subtype PubMed ID
esv2718872 CNV deletion 23290073
esv2718879 CNV deletion 23290073
esv2758771 CNV gain+loss 17122850
esv2763132 CNV gain+loss 21179565
nsv1061041 CNV loss 25217958
nsv1061739 CNV gain+loss 25217958
nsv1160664 CNV deletion 26073780
nsv428372 CNV gain+loss 18775914
nsv458799 CNV gain 19166990
nsv470158 CNV loss 18288195
nsv470159 CNV gain 18288195
nsv518953 CNV loss 19592680
nsv523723 CNV loss 19592680
nsv524470 CNV gain 19592680
nsv580240 CNV gain 21841781
nsv580241 CNV loss 21841781
nsv580242 CNV gain 21841781
nsv580243 CNV gain 21841781
nsv817871 CNV loss 17921354
nsv828639 CNV loss 20364138
nsv833879 CNV gain+loss 17160897
nsv9760 CNV loss 18304495
esv2667609 CNV deletion 23128226
esv2422341 CNV duplication 17116639
dgv3665n100 CNV gain 25217958
dgv17e196 CNV deletion 17116639
dgv16e196 CNV duplication 17116639

Variation tolerance for LILRB4 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.07; 90.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LILRB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LILRB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB4 Gene

Disorders for LILRB4 Gene

Relevant External Links for LILRB4

Genetic Association Database (GAD)
LILRB4
Human Genome Epidemiology (HuGE) Navigator
LILRB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LILRB4

No disorders were found for LILRB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LILRB4 Gene

Publications for LILRB4 Gene

  1. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PMID: 9151699) Cella M. … Colonna M. (J. Exp. Med. 1997) 2 3 4 22 64
  2. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PMID: 11875462) Chang C.C. … Suciu-Foca N. (Nat. Immunol. 2002) 3 4 22 64
  3. Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (PMID: 10940079) Heinzmann A. … Deichmann K.A. (Eur. J. Immunogenet. 2000) 3 22 46 64
  4. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PMID: 10941837) Liu W.R. … Arm J.P. (Immunogenetics 2000) 3 4 22 64
  5. Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR- 5/CD85k): a myeloid inhibitory receptor involved in immune tolerance. (PMID: 21454581) Cheng H. … Gao G.F. (J. Biol. Chem. 2011) 3 4 64

Products for LILRB4 Gene

Sources for LILRB4 Gene

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