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Aliases for LILRB4 Gene

Aliases for LILRB4 Gene

  • Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 4 2 3
  • ILT3 3 4 6
  • LIR5 3 4 6
  • Leukocyte Immunoglobulin-Like Receptor 5 3 4
  • Monocyte Inhibitory Receptor HM18 3 4
  • CD85 Antigen-Like Family Member K 3 4
  • Immunoglobulin-Like Transcript 3 3 4
  • ILT-3 3 4
  • LIR-5 3 4
  • Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 3
  • CD85k Antigen 4
  • CD85K 3
  • HM18 6

External Ids for LILRB4 Gene

Previous GeneCards Identifiers for LILRB4 Gene

  • GC19U990164
  • GC19P055599
  • GC19P059762
  • GC19P059866
  • GC19P055155
  • GC19P051497

Summaries for LILRB4 Gene

Entrez Gene Summary for LILRB4 Gene

  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for LILRB4 Gene

LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include receptor activity and antigen binding. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot for LILRB4 Gene

  • Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Wiki entry for LILRB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LILRB4 Gene

Genomics for LILRB4 Gene

Regulatory Elements for LILRB4 Gene

Genomic Location for LILRB4 Gene

54,643,889 bp from pter
54,670,359 bp from pter
26,471 bases
Plus strand

Genomic View for LILRB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LILRB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LILRB4 Gene

Proteins for LILRB4 Gene

  • Protein details for LILRB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 4
    Protein Accession:
    Secondary Accessions:
    • A8MVL8
    • O15468
    • O75021
    • Q6FGQ9
    • Q8N1C7
    • Q8NHL5

    Protein attributes for LILRB4 Gene

    448 amino acids
    Molecular mass:
    49356 Da
    Quaternary structure:
    • Binds PTPN6 when phosphorylated

    Three dimensional structures from OCA and Proteopedia for LILRB4 Gene

    Alternative splice isoforms for LILRB4 Gene


neXtProt entry for LILRB4 Gene

Proteomics data for LILRB4 Gene at MOPED

Post-translational modifications for LILRB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for LILRB4 (LILRB4/CD85k/ILT3)

No data available for DME Specific Peptides for LILRB4 Gene

Domains for LILRB4 Gene

Gene Families for LILRB4 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LILR :Leukocyte immunoglobulin-like receptors

Protein Domains for LILRB4 Gene


Suggested Antigen Peptide Sequences for LILRB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NHJ6
  • Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with LILRB4: view

Function for LILRB4 Gene

Molecular function for LILRB4 Gene

GENATLAS Biochemistry: leukocyte immunoglobulin-like receptor,subfamily B,member 4,mouse Gp49B-1 ortholog,expressed on monocytes,B cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor superfamily,with several alternatively spliced isoforms
UniProtKB/Swiss-Prot Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
UniProtKB/Swiss-Prot Induction: Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells

Gene Ontology (GO) - Molecular Function for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 9151699
GO:0004872 receptor activity TAS 9151699
GO:0005515 protein binding IPI 18802077
genes like me logo Genes that share ontologies with LILRB4: view

Animal Model Products

CRISPR Products

miRNA for LILRB4 Gene

miRTarBase miRNAs that target LILRB4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LILRB4 Gene

Localization for LILRB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LILRB4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Subcellular locations from

Jensen Localization Image for LILRB4 Gene COMPARTMENTS Subcellular localization image for LILRB4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LILRB4: view

Pathways for LILRB4 Gene

genes like me logo Genes that share pathways with LILRB4: view

Pathways by source for LILRB4 Gene

Interacting Proteins for LILRB4 Gene

Gene Ontology (GO) - Biological Process for LILRB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 9151699
GO:0045671 negative regulation of osteoclast differentiation IDA 18802077
genes like me logo Genes that share ontologies with LILRB4: view

Compounds for LILRB4 Gene

(1) HMDB Compounds for LILRB4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for LILRB4 Gene

Compound -log(P) Hits PubMed IDs
leucine 18.5 1
tyrosine 4.21 5
genes like me logo Genes that share compounds with LILRB4: view

Transcripts for LILRB4 Gene

mRNA/cDNA for LILRB4 Gene

Unigene Clusters for LILRB4 Gene

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LILRB4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LILRB4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP4: - - -
SP5: -
SP6: - -

Relevant External Links for LILRB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LILRB4 Gene

mRNA expression in normal human tissues for LILRB4 Gene

mRNA differential expression in normal tissues according to GTEx for LILRB4 Gene

This gene is overexpressed in Whole Blood (13.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LILRB4 Gene

SOURCE GeneReport for Unigene cluster for LILRB4 Gene Hs.67846

mRNA Expression by UniProt/SwissProt for LILRB4 Gene

Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.
genes like me logo Genes that share expressions with LILRB4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LILRB4 Gene

Orthologs for LILRB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LILRB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LILRB4 35
  • 97.13 (n)
  • 94.94 (a)
  • 96 (a)
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
(Canis familiaris)
Mammalia -- 36
  • 25 (a)
(Mus musculus)
Mammalia Lilra5 36
  • 39 (a)
Lilrb4 35
  • 63.14 (n)
  • 50 (a)
(Rattus norvegicus)
Mammalia Lilrb4 35
  • 58.9 (n)
  • 48.19 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 12 (a)
Species with no ortholog for LILRB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LILRB4 Gene

Gene Tree for LILRB4 (if available)
Gene Tree for LILRB4 (if available)

Paralogs for LILRB4 Gene Pseudogenes for LILRB4 Gene

genes like me logo Genes that share paralogs with LILRB4: view

Variants for LILRB4 Gene

Sequence variations from dbSNP and Humsavar for LILRB4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs370156 -- 54,661,088(+) CTCCT(A/G)CAAGC upstream-variant-2KB
rs398244 -- 54,662,393(+) tgagg(C/T)tggag upstream-variant-2KB
rs400322 -- 54,661,127(+) GATAC(A/G)ATTAA upstream-variant-2KB
rs413679 -- 54,662,355(-) tgctt(C/G)catgc upstream-variant-2KB
rs423210 -- 54,662,422(-) aggct(C/T)ccgca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LILRB4 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073
nsv470158 CNV Loss 18288195
dgv16e196 CNV Duplication 17116639
dgv17e196 CNV Deletion 17116639
dgv1126e1 CNV Complex 17122850
nsv428372 CNV Gain+Loss 18775914
nsv458799 CNV Gain 19166990
dgv4006n71 CNV Loss 21882294
esv2718879 CNV Deletion 23290073
nsv9760 CNV Loss 18304495
nsv828639 CNV Loss 20364138
nsv470159 CNV Gain 18288195
nsv523723 CNV Loss 19592680
nsv817871 CNV Loss 17921354
nsv912419 CNV Loss 21882294
essv4924 CNV CNV 17122850
esv2422341 CNV Duplication 17116639
nsv518953 CNV Loss 19592680
nsv833879 CNV Gain+Loss 17160897
nsv524470 CNV Gain 19592680

Relevant External Links for LILRB4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LILRB4 Gene

Disorders for LILRB4 Gene

Relevant External Links for LILRB4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LILRB4: view

No data available for UniProtKB/Swiss-Prot for LILRB4 Gene

Publications for LILRB4 Gene

  1. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PMID: 9151699) Cella M. … Colonna M. (J. Exp. Med. 1997) 2 3 4 23
  2. Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (PMID: 10940079) Heinzmann A. … Deichmann K.A. (Eur. J. Immunogenet. 2000) 3 23 48
  3. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PMID: 10941837) Liu W.R. … Arm J.P. (Immunogenetics 2000) 3 4 23
  4. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PMID: 11875462) Chang C.C. … Suciu-Foca N. (Nat. Immunol. 2002) 3 4 23
  5. Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies. (PMID: 16406677) Garner L.I. … Willcox B.E. (Protein Expr. Purif. 2006) 3 23

Products for LILRB4 Gene

Sources for LILRB4 Gene

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