LILRB4 Gene
protein-coding GIFtS: 57
GCID: GC19P055155
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leukocyte immunoglobulin-like receptor, subfamily B (with...
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Aliases
for LILRB4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIMDomains), Member 41 2 | | CD85 Antigen-Like Family Member K2 3 | | ILT31 2 3 5 | | CD85k1 | | LIR51 2 3 5 | | CD85K2 | | LIR-51 2 3 | | LILRB52 | | HM181 2 5 | | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 42 | | Immunoglobulin-Like Transcript 32 3 | | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 4 Soluble Isoform2 | | Leukocyte Immunoglobulin-Like Receptor 52 3 | | Leukocyte Immunoglobulin-Like Receptor, Subfamily B, Member 42 | | Monocyte Inhibitory Receptor HM182 3 | | CD85k Antigen3 | | ILT-32 3 | | |
Export aliases for LILRB4 gene to outside databasesPrevious GC identifers: GC19U990164 GC19P055599 GC19P059762 GC19P059866 GC19P051497 |
Summaries
for LILRB4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LILRB4:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster atchromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two orfour extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptortyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class Imolecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immuneresponse. The receptor can also function in antigen capture and presentation. It is thought to control inflammatoryresponses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants.Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellularproteins and mobilization of intracellular calcium ions
Gene Wiki entry for LILRB4
|
Genomic Views
for LILRB4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LILRB4 gene promoter:
NRSF form 1 NF-kappaB NRSF form 2 Meis-1b E47 CREB HEN1 Meis-1a NF-kappaB1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LILRB4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4LILRB4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055155: view genomic region
(about GC identifiers)
Start:
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55,155,340 bp from pter |
End:
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55,181,810 bp from pter |
Size:
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26,471 bases |
Orientation:
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plus strand |
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Proteins
for LILRB4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6 (See
protein sequence)Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor Size: 448 amino acids; 49356 Da
Subunit: Binds PTPN6 when phosphorylated
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalizationand translocation to an antigen-processing compartment
1 PDB 3D structure from  and Proteopedia  for LILRB4:3P2T (3D)
Secondary accessions: A8MVL8 O15468 O75021 Q6FGQ9 Q8N1C7 Q8NHL5Alternative splicing: 3 isoforms: Q8NHJ6-1 Q8NHJ6-2 Q8NHJ6-3 (Alternative use of an acceptor site. No experimental confirmation available)Explore the universe of human proteins at neXtProt for LILRB4: NX_Q8NHJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NHJ6
LILRB4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001074907.1 NP_006838.3
ENSEMBL proteins: ENSP00000404264 ENSP00000375616 ENSP00000408995 ENSP00000375614 ENSP00000375613 ENSP00000401962 ENSP00000270452 Reactome Protein details: Q8NHJ6
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
LILRB4 for ontologies About GeneDecksing
LILRB4 Antibody Products:
Assay Products for LILRB4: |
Protein
Domains /
Families
for LILRB4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LILRB4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NHJ6ProtoNet protein and cluster: Q8NHJ6 UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitormotif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind theSH2 domain of several SH2-containing phosphatasesSimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for LILRB4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants.Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellularproteins and mobilization of intracellular calcium ionsInduction: Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells Genatlas biochemistry entry for LILRB4:leukocyte immunoglobulin-like receptor,subfamily B,member 4,mouse Gp49B-1 ortholog,expressed on monocytes,Bcells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptorsuperfamily,with several alternatively spliced isoforms
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRB4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
LILRB4 for ontologies About GeneDecksing
|
Pathways & Interactions
for LILRB4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Osteoclast differentiation | | | 3 | Cleavage of Alpha-1-Microglobulin | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for LILRB4
1 
Kegg Pathway (Kegg details for LILRB4):
LILRB4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LILRB4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for LILRB4 (Q8NHJ63 ENSP000002704524) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
LILRB4 for ontologies About GeneDecksing
|
Drugs & Compounds
for LILRB4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LILRB4 for compounds About GeneDecksing
 Browse Tocris compounds for LILRB4
1 HMDB Compound for LILRB4 About this table
2 Novoseek chemical compound relationships for LILRB4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
18.5 |
1 |
17163451 (1) |
| tyrosine |
4.21 |
6 |
9151699 (3), 19833736 (1), 10940079 (1) |
Search CenterWatch for drugs/clinical trials and news about LILRB4 / LIRB4
|
Transcripts
for LILRB4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LILRB4 gene (2 alternative transcripts): NM_001081438.1 NM_006847.3 Unigene Cluster for LILRB4: Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 Hs.67846 [show with all ESTs]Unigene Representative Sequence: BC02630912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461839(uc002qgn.3) ENST00000420271 ENST00000391736(uc010ert.3 uc010eru.3)
ENST00000494796 ENST00000430952 ENST00000391734 ENST00000391733 ENST00000434286
ENST00000484241 ENST00000470943 ENST00000461262 ENST00000270452(uc002qgo.1 uc002qgp.3 uc002qgq.3 uc010ers.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRB4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRB4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LILRB4 (NM_006847) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LILRB4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRB4 |
Additional cDNA sequence: AF025532.1 AF283988.1 AK292082.1 AK309227.1 AK314783.1 BC026309.1 CR542048.1 EU915607.1 U82979.1 U91925.1 7 DOTS entries: DT.91743402 DT.121433052 DT.210091 DT.75135614 DT.91743401 DT.95129900 DT.92026436 5 AceView cDNA sequences: AF283988 BU175229 AI371323 CR609786 NM_006847
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LILRB4 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LILRB4
|
Expression
for LILRB4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LILRB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAAATGGG
About this image
See LILRB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LILRB4
SOURCE GeneReport for Unigene cluster: Hs.67846
UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells
SABiosciences Custom PCR Arrays for LILRB4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRB4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LILRB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRB4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB4 |
Orthologs
for LILRB4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LILRB4 gene from 2/5 species (see all 5) About this table
ENSEMBL Gene Tree for LILRB4 (if available)
TreeFam Gene Tree for LILRB4 (if available) |
Paralogs
for LILRB4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LILRB4 gene
- KIR2DL42 LILRB12 LILRA62 IGSF12 LILRA52 KIR3DL12 OSCAR2 NCR12
- LILRA42 ENSG000002177922 TARM12 KIR3DX12 LILRA32 LILRB52 LILRA12 KIR3DL32
- KIR2DL12 LILRB22 A1BG2 KIR2DL22 LILRA22 KIR3DL22 KIR2DL32 FCAR2
- LILRB32 GP62
18/39 SIMAP similar genes for LILRB4 using alignment to 4 protein entries: LIRB4_HUMAN (see all proteins)
(see all similar genes):LILRA5 LILRB1 LILRA4 LILRA3 LILRB2 LILRB3
MIR cl-10 FLJ00275 LILRA6 LILRA1 LILRA2 LAIR2
KIR-K36 KIR-G1 NCR1 KIR-K64 LAIR1 1060P11.3
LILRB4 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for LILRB4
PGOHUM00000250589 PGOHUM00000234786 PGOHUM00000263319
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Genomic Variants
for LILRB4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LILRB4 (55155340 - 55181810 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for LILRB4
10 CNVs: 4088 5117 30083 32270 5344 3200 29696 5345 5447 10568 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRB4 |
|
Disorders
/ Diseases
for LILRB4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LILRB4 for disorders About GeneDecksing
OMIM gene information: 604821
OMIM disorders: --
7  diseases for LILRB4: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia multiple sclerosis atopy
hepatitis b leukemia hepatitis
Genetic Association Database (GAD): LILRB4
Human Genome Epidemiology (HuGE) Navigator: LILRB4 (3 documents)
Export disorders for LILRB4 gene to outside databases
|
Publications
for LILRB4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LILRB4 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with LILRB4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PubMed id 9151699)1, 2, 3, 9 Cella M.... Colonna M. (1997)
- Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (PubMed id 10940079)1, 4, 9 Heinzmann A....Deichmann K.A. (2000)
- Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PubMed id 11875462)1, 2, 9 Chang C.C....Suciu-Foca N. (2002)
- Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PubMed id 10941837)1, 2, 9 Liu W.R.... Arm J.P. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new sti mulatory and inhibitory pathways. (PubMed id 9079806)1, 3 Samaridis J. and Colonna M. (1997)
- Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2 Arm J.P.... Austen K.F. (1997)
- A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L....Cosman D. (1997)
- Leukocyte Ig-like receptor B4 (LILRB4) is a potent in hibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of mult iple kinases. (PubMed id 19833736)1, 9 Lu H.K....Tedla N. (2009)
- Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia. (PubMed id 17266150)1, 9 Colovai A.I....Suciu-Foca N. (2007)
|
External Searches for LILRB4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LILRB4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LILRB4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LILRB4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LILRB4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LILRB4 gene:
Search GeneIP for patents involving LILRB4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LILRB4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LILRB4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LILRB4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LILRB4 | | | OriGene Protein Over-expression Lysate for LILRB4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LILRB4 | | OriGene 3'-UTR Clone for LILRB4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LILRB4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LILRB4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LILRB4 | | OriGene Custom Protein Services for LILRB4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LILRB4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LILRB4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LILRB4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LILRB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LILRB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LILRB4 |
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| | | | Search Tocris compounds for LILRB4 |
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 | | | LILRB4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LILRB4 |
|  |  |  | | | | Search ThermoFisher Antibodies for LILRB4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LILRB4 |
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