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LILRB4 Gene

protein-coding   GIFtS: 58
GCID: GC19P055155

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM
Domains), Member 41 2
     LIR-52 3
ILT32 3 5     CD85 Antigen-Like Family Member K2 3
LIR52 3 5     CD85K2
Immunoglobulin-Like Transcript 32 3     Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 42
Leukocyte Immunoglobulin-Like Receptor 52 3     CD85k Antigen3
Monocyte Inhibitory Receptor HM182 3     HM185
ILT-32 3     

External Ids:    HGNC: 66081   Entrez Gene: 110062   Ensembl: ENSG000001868187   OMIM: 6048215   UniProtKB: Q8NHJ63   

Export aliases for LILRB4 gene to outside databases

Previous GC identifers: GC19U990164 GC19P055599 GC19P059762 GC19P059866 GC19P051497


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LILRB4 Gene:
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster
at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which
contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic
immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds
to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation
of an immune response. The receptor can also function in antigen capture and presentation. It is thought to
control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for LILRB4 Gene:
LILRB4 (leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4) is a protein-coding gene. GO annotations related to this gene include antigen binding and receptor activity. An important paralog of this gene is KIR2DL4.

UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6
Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards
transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated
phosphorylation of cellular proteins and mobilization of intracellular calcium ions

Gene Wiki entry for LILRB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LILRB4 gene promoter:
         NRSF form 1   NF-kappaB   NRSF form 2   Meis-1b   E47   CREB   HEN1   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLILRB4 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LILRB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LILRB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LILRB4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055155:  view genomic region     (about GC identifiers)

Start:
55,155,340 bp from pter      End:
55,181,810 bp from pter
Size:
26,471 bases      Orientation:
plus strand

3 alternative locations:
Chr19+,NW_003571060 567,554-573,279      Chr19+,NW_003571054 569,063-574,800      Chr19+,NW_003571061 389,162-394,900     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6 (See protein sequence)
Recommended Name: Leukocyte immunoglobulin-like receptor subfamily B member 4 precursor  
Size: 448 amino acids; 49356 Da
Subunit: Binds PTPN6 when phosphorylated
1 PDB 3D structure from and Proteopedia for LILRB4:
3P2T (3D)    
Secondary accessions: A8MVL8 O15468 O75021 Q6FGQ9 Q8N1C7 Q8NHL5
Alternative splicing: 3 isoforms:  Q8NHJ6-1   Q8NHJ6-2   Q8NHJ6-3   (Alternative use of an acceptor site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LILRB4: NX_Q8NHJ6

Explore proteomics data for LILRB4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LILRB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265355.1  NP_001265356.1  NP_001265357.1  NP_001265358.1  NP_001265359.1  

    ENSEMBL proteins: 
     ENSP00000375616   ENSP00000408995   ENSP00000375614   ENSP00000375613   ENSP00000401962  
     ENSP00000270452  
    Reactome Protein details: Q8NHJ6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LILR: Leukocyte immunoglobulin-like receptors
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8NHJ6

    ProtoNet protein and cluster: Q8NHJ6

    UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6
    Domain: Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based
    inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif
    can bind the SH2 domain of several SH2-containing phosphatases
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with LILRB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIRB4_HUMAN, Q8NHJ6
    Function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
    Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards
    transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated
    phosphorylation of cellular proteins and mobilization of intracellular calcium ions
    Induction: Upon contact with CD8(+)CD28(-) alloantigen-specific T suppressor (Ts) cells

         Genatlas biochemistry entry for LILRB4:
    leukocyte immunoglobulin-like receptor,subfamily B,member 4,mouse Gp49B-1 ortholog,expressed on monocytes,B
    cells,dentritic and natural killer cells,related to the Fc alpha receptor and natural killed inhibitory receptor
    superfamily,with several alternatively spliced isoforms

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS9151699
    GO:0004872receptor activity TAS9151699
    GO:0005515protein binding IPI18802077
         
    Find genes that share ontologies with LILRB4           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIRB4_HUMAN, Q8NHJ6: Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to
    internalization and translocation to an antigen-processing compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LILRB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LILRB4 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Osteoclast differentiation
    Osteoclast differentiation
    3Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Find genes that share SuperPaths with LILRB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for LILRB4
        Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for LILRB4):
        Osteoclast differentiation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LILRB4
    Interactions:

        GeneGlobe Interaction Network for LILRB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for LILRB4 (Q8NHJ63 ENSP000002704524) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6P293503, ENSP000003915924I2D: score=4 STRING: ENSP00000391592
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    INPP5DQ928353, ENSP000003525754I2D: score=2 STRING: ENSP00000352575
    FCGR2AENSP000002714504STRING: ENSP00000271450
    FCGR3AENSP000003569464STRING: ENSP00000356946
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0007165signal transduction TAS9151699
    GO:0045671negative regulation of osteoclast differentiation IDA18802077

    Find genes that share ontologies with LILRB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for LILRB4 (LIRB4)

    1 HMDB Compound for LILRB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for LILRB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 18.5 1 17163451 (1)
    tyrosine 4.21 6 9151699 (3), 19833736 (1), 10940079 (1)



    Find genes that share compounds with LILRB4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LILRB4 gene (7 alternative transcripts): 
    NM_001278426.2  NM_001278427.2  NM_001278428.2  NM_001278429.2  NM_001278430.2  NM_001081438.1  NM_006847.3  

    Unigene Cluster for LILRB4:

    Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
    Hs.67846  [show with all ESTs]
    Unigene Representative Sequence: BC026309
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461839(uc002qgn.3) ENST00000391736(uc010ert.3 uc010eru.3)
    ENST00000494796 ENST00000430952 ENST00000391734 ENST00000391733 ENST00000434286
    ENST00000470943 ENST00000461262 ENST00000270452(uc002qgo.1 uc002qgp.3 uc002qgq.3 uc010ers.1)

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    Additional mRNA sequence: 

    AF025532.1 AF283988.1 AK292082.1 AK309227.1 AK314783.1 BC026309.1 CR542048.1 EU915607.1 
    U82979.1 U91925.1 

    7 DOTS entries:

    DT.91743402  DT.121433052  DT.210091  DT.75135614  DT.91743401  DT.95129900  DT.92026436 

    5 AceView cDNA sequences:

    AF283988 AI371323 BU175229 CR609786 NM_006847 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LILRB4 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                -     -     -                                                                     
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                                -     -     -                                                                     
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for LILRB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LILRB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAATGGG
    LILRB4 Expression
    About this image

    LILRB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LILRB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.67846

    UniProtKB/Swiss-Prot: LIRB4_HUMAN, Q8NHJ6
    Tissue specificity: Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LILRB4 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lilrb41 leukocyte immunoglobulin-like receptor, subfamily B, more 63.14(n)
    50(a)
      14728  NM_013532.2  NP_038560.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    12(a)
    1 → many
    GL343329.1(823590-844642)


    ENSEMBL Gene Tree for LILRB4 (if available)
    TreeFam Gene Tree for LILRB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LILRB4 gene
    KIR2DL42  LILRB12  KIR2DS42  LILRA62  LILRA52  IGSF12  KIR3DL12  OSCAR2  
    NCR12  LILRA42  ENSG000002177922  TARM12  KIR3DX12  LILRA32  LILRB52  KIR3DL32  
    LILRA12  KIR3DS12  KIR2DL12  A1BG2  LILRB22  KIR3DL22  LILRA22  KIR2DL32  
    FCAR2  GP62  LILRB32  
    Selected SIMAP similar genes for LILRB4 using alignment to 3 protein entries:     LIRB4_HUMAN (see all proteins) (see all similar genes):
    LILRA5    LILRB1    LILRA4    LILRB2    MIR cl-10    FLJ00275
    LILRA3    LILRB3    LILRA6    LILRA1    LILRA2    KIR-K36
    KIR-G1    NCR1    LAIR2    KIR-K64    KIR-K15    KIR-K3

    Find genes that share paralogs with LILRB4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for LILRB4
    PGOHUM00000250589 PGOHUM00000234786 PGOHUM00000263319


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LILRB4 (see all 405)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9344341,2
    C,F,O,A,H--55172146(+) GAATTC/TCTGAA 2 -- us2k125Minor allele frequency- T:0.35EA NA NS WA CSA 2107
    rs115745651,2
    C,F,H--55172157(+) ATCAGC/TATGCA 2 -- us2k110Minor allele frequency- T:0.08NA NS EA WA CSA 690
    rs115745661,2
    C,F,H--55172167(+) ATTGCG/AGACAC 2 -- us2k112Minor allele frequency- A:0.04NA NS EA CSA WA 706
    rs1849017921,2
    --55172228(+) GCAGAA/CCATCA 2 -- us2k10--------
    rs1508333621,2
    --55172247(+) TTCCCG/TCCAAA 2 -- us2k10--------
    rs1394908751,2
    --55172419(+) GATACC/TGTCCC 2 -- us2k10--------
    rs1156112851,2
    F--55172424(+) TGTCCC/TGTGAT 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1443434961,2
    --55172508(+) TCATGC/TGTTTC 2 -- us2k10--------
    rs115745671,2
    C,F,H--55172509(+) CATGCG/ATTTCC 2 -- us2k124Minor allele frequency- A:0.04NA NS EA CSA WA 2682
    rs3701561,2
    C,F,A,H--55172539(+) CTCCTG/ACAAGC 2 -- us2k119Minor allele frequency- A:0.11MN NA NS EA 2474

    HapMap Linkage Disequilibrium report for LILRB4 (55155340 - 55181810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LILRB4 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667609CNV Deletion23128226
    esv2718879CNV Deletion23290073
    dgv17e196CNV Deletion17116639
    esv2718872CNV Deletion23290073
    esv2422341CNV Duplication17116639
    dgv16e196CNV Duplication17116639
    dgv4006n71CNV Loss21882294
    nsv9760CNV Loss18304495
    nsv912419CNV Loss21882294
    nsv470158CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LILRB4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604821    OMIM disorders: --


    Find genes that share disorders with LILRB4           About GenesLikeMe

    Genetic Association Database (GAD): LILRB4
    Human Genome Epidemiology (HuGE) Navigator: LILRB4 (3 documents)

    Export disorders for LILRB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LILRB4 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with LILRB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. (PubMed id 9151699)1, 2, 3, 9 Cella M.... Colonna M. (J. Exp. Med. 1997)
    2. Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (PubMed id 10940079)1, 4, 9 Heinzmann A....Deichmann K.A. (Eur. J. Immunogenet. 2000)
    3. Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. (PubMed id 11875462)1, 2, 9 Chang C.C....Suciu-Foca N. (Nat. Immunol. 2002)
    4. Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. (PubMed id 10941837)1, 2, 9 Liu W.R.... Arm J.P. (Immunogenetics 2000)
    5. Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR- 5/CD85k): a myeloid inhibitory receptor involved in immune tolerance. (PubMed id 21454581)1, 2 Cheng H.... Gao G.F. (J. Biol. Chem. 2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. (PubMed id 9278324)1, 2 Arm J.P.... Austen K.F. (J. Immunol. 1997)
    8. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. (PubMed id 9548455)1, 2 Borges L.... Cosman D. (J. Immunol. 1997)
    9. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. (PubMed id 9079806)1, 3 Samaridis J. and Colonna M. (Eur. J. Immunol. 1997)
    10. Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases. (PubMed id 19833736)1, 9 Lu H.K....Tedla N. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11006 HGNC: 6608 AceView: LILRB4 Ensembl:ENSG00000186818 euGenes: HUgn11006
    ECgene: LILRB4 Kegg: 11006 H-InvDB: LILRB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LILRB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LILRB4 gene:
    Search GeneIP for patents involving LILRB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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